-- dump date   	20140619_014216
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1229205000001	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
1229205000002	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
1229205000003	trehalose synthase; Region: treS_nterm; TIGR02456
1229205000004	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
1229205000005	active site
1229205000006	catalytic site [active]
1229205000007	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331
1229205000008	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1229205000009	active site
1229205000010	catalytic site [active]
1229205000011	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1229205000012	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205000013	ATP binding site [chemical binding]; other site
1229205000014	Mg2+ binding site [ion binding]; other site
1229205000015	G-X-G motif; other site
1229205000016	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1229205000017	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1229205000018	PAS domain; Region: PAS; smart00091
1229205000019	PAS fold; Region: PAS_4; pfam08448
1229205000020	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229205000021	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205000022	dimer interface [polypeptide binding]; other site
1229205000023	phosphorylation site [posttranslational modification]
1229205000024	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205000025	ATP binding site [chemical binding]; other site
1229205000026	G-X-G motif; other site
1229205000027	Response regulator receiver domain; Region: Response_reg; pfam00072
1229205000028	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205000029	active site
1229205000030	phosphorylation site [posttranslational modification]
1229205000031	intermolecular recognition site; other site
1229205000032	dimerization interface [polypeptide binding]; other site
1229205000033	Chemotaxis phosphatase CheX; Region: CheX; cl15816
1229205000034	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
1229205000035	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205000036	active site
1229205000037	phosphorylation site [posttranslational modification]
1229205000038	intermolecular recognition site; other site
1229205000039	dimerization interface [polypeptide binding]; other site
1229205000040	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1229205000041	Zn2+ binding site [ion binding]; other site
1229205000042	Mg2+ binding site [ion binding]; other site
1229205000043	Protein of unknown function DUF72; Region: DUF72; pfam01904
1229205000044	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
1229205000045	Fe-S cluster binding site [ion binding]; other site
1229205000046	active site
1229205000047	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
1229205000048	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
1229205000049	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
1229205000050	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
1229205000051	Flavin binding site [chemical binding]; other site
1229205000052	Protein of unknown function, DUF480; Region: DUF480; pfam04337
1229205000053	D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409
1229205000054	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1229205000055	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1229205000056	BON domain; Region: BON; pfam04972
1229205000057	Acetokinase family; Region: Acetate_kinase; cl17229
1229205000058	putative phosphoketolase; Provisional; Region: PRK05261
1229205000059	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
1229205000060	TPP-binding site; other site
1229205000061	XFP C-terminal domain; Region: XFP_C; pfam09363
1229205000062	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
1229205000063	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1229205000064	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1229205000065	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1229205000066	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
1229205000067	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1229205000068	sugar efflux transporter; Region: 2A0120; TIGR00899
1229205000069	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205000070	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1229205000071	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1229205000072	catalytic residues [active]
1229205000073	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
1229205000074	Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948
1229205000075	active site
1229205000076	intersubunit interface [polypeptide binding]; other site
1229205000077	catalytic residue [active]
1229205000078	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229205000079	His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388
1229205000080	dimer interface [polypeptide binding]; other site
1229205000081	phosphorylation site [posttranslational modification]
1229205000082	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205000083	ATP binding site [chemical binding]; other site
1229205000084	Mg2+ binding site [ion binding]; other site
1229205000085	G-X-G motif; other site
1229205000086	Response regulator receiver domain; Region: Response_reg; pfam00072
1229205000087	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205000088	active site
1229205000089	phosphorylation site [posttranslational modification]
1229205000090	intermolecular recognition site; other site
1229205000091	dimerization interface [polypeptide binding]; other site
1229205000092	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1229205000093	iron-sulfur cluster [ion binding]; other site
1229205000094	[2Fe-2S] cluster binding site [ion binding]; other site
1229205000095	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1229205000096	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1229205000097	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1229205000098	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1229205000099	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
1229205000100	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
1229205000101	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
1229205000102	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
1229205000103	active site
1229205000104	catalytic site [active]
1229205000105	PRC-barrel domain; Region: PRC; pfam05239
1229205000106	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1229205000107	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1229205000108	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1229205000109	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
1229205000110	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
1229205000111	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
1229205000112	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1229205000113	catalytic loop [active]
1229205000114	iron binding site [ion binding]; other site
1229205000115	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1229205000116	short chain dehydrogenase; Provisional; Region: PRK06701
1229205000117	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
1229205000118	NAD binding site [chemical binding]; other site
1229205000119	metal binding site [ion binding]; metal-binding site
1229205000120	active site
1229205000121	Response regulator receiver domain; Region: Response_reg; pfam00072
1229205000122	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205000123	active site
1229205000124	phosphorylation site [posttranslational modification]
1229205000125	intermolecular recognition site; other site
1229205000126	dimerization interface [polypeptide binding]; other site
1229205000127	ATP-dependent DNA ligase; Validated; Region: PRK09247
1229205000128	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
1229205000129	active site
1229205000130	DNA binding site [nucleotide binding]
1229205000131	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
1229205000132	DNA binding site [nucleotide binding]
1229205000133	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
1229205000134	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1229205000135	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
1229205000136	Predicted ATPase [General function prediction only]; Region: COG1485
1229205000137	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1229205000138	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1229205000139	TPP-binding site [chemical binding]; other site
1229205000140	dimer interface [polypeptide binding]; other site
1229205000141	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1229205000142	PYR/PP interface [polypeptide binding]; other site
1229205000143	dimer interface [polypeptide binding]; other site
1229205000144	TPP binding site [chemical binding]; other site
1229205000145	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1229205000146	Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297
1229205000147	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205000148	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205000149	trimer interface [polypeptide binding]; other site
1229205000150	eyelet of channel; other site
1229205000151	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
1229205000152	Walker A motif; other site
1229205000153	ATP binding site [chemical binding]; other site
1229205000154	Walker B motif; other site
1229205000155	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1229205000156	metal ion-dependent adhesion site (MIDAS); other site
1229205000157	MarC family integral membrane protein; Region: MarC; cl00919
1229205000158	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
1229205000159	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1229205000160	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
1229205000161	Na binding site [ion binding]; other site
1229205000162	glycogen synthase; Provisional; Region: glgA; PRK00654
1229205000163	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
1229205000164	homodimer interface [polypeptide binding]; other site
1229205000165	ADP-binding pocket [chemical binding]; other site
1229205000166	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1229205000167	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1229205000168	metal binding site [ion binding]; metal-binding site
1229205000169	active site
1229205000170	I-site; other site
1229205000171	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
1229205000172	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
1229205000173	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1229205000174	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1229205000175	active site
1229205000176	metal binding site [ion binding]; metal-binding site
1229205000177	Peptidase family M1; Region: Peptidase_M1; pfam01433
1229205000178	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
1229205000179	Zn binding site [ion binding]; other site
1229205000180	Epoxide hydrolase N terminus; Region: EHN; pfam06441
1229205000181	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1229205000182	LrgA family; Region: LrgA; pfam03788
1229205000183	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
1229205000184	Trehalase; Region: Trehalase; cl17346
1229205000185	Trehalase; Region: Trehalase; cl17346
1229205000186	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
1229205000187	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
1229205000188	active site clefts [active]
1229205000189	zinc binding site [ion binding]; other site
1229205000190	dimer interface [polypeptide binding]; other site
1229205000191	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
1229205000192	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229205000193	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205000194	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205000195	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
1229205000196	active site
1229205000197	SAM binding site [chemical binding]; other site
1229205000198	homodimer interface [polypeptide binding]; other site
1229205000199	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
1229205000200	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
1229205000201	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
1229205000202	active site
1229205000203	putative homodimer interface [polypeptide binding]; other site
1229205000204	SAM binding site [chemical binding]; other site
1229205000205	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
1229205000206	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229205000207	S-adenosylmethionine binding site [chemical binding]; other site
1229205000208	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1229205000209	precorrin-3B synthase; Region: CobG; TIGR02435
1229205000210	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1229205000211	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
1229205000212	Precorrin-8X methylmutase; Region: CbiC; pfam02570
1229205000213	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
1229205000214	active site
1229205000215	SAM binding site [chemical binding]; other site
1229205000216	homodimer interface [polypeptide binding]; other site
1229205000217	Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073
1229205000218	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
1229205000219	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
1229205000220	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
1229205000221	active site
1229205000222	SAM binding site [chemical binding]; other site
1229205000223	homodimer interface [polypeptide binding]; other site
1229205000224	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229205000225	AAA domain; Region: AAA_23; pfam13476
1229205000226	Walker A/P-loop; other site
1229205000227	ATP binding site [chemical binding]; other site
1229205000228	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229205000229	Q-loop/lid; other site
1229205000230	ABC transporter signature motif; other site
1229205000231	Walker B; other site
1229205000232	D-loop; other site
1229205000233	H-loop/switch region; other site
1229205000234	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1229205000235	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1229205000236	active site
1229205000237	metal binding site [ion binding]; metal-binding site
1229205000238	DNA binding site [nucleotide binding]
1229205000239	Protein of unknown function (DUF445); Region: DUF445; pfam04286
1229205000240	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1229205000241	FAD-dependent oxidoreductase; Provisional; Region: PRK08132
1229205000242	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1229205000243	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1229205000244	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1229205000245	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1229205000246	aldolase II superfamily protein; Provisional; Region: PRK07044
1229205000247	intersubunit interface [polypeptide binding]; other site
1229205000248	active site
1229205000249	Zn2+ binding site [ion binding]; other site
1229205000250	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
1229205000251	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229205000252	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205000253	homodimer interface [polypeptide binding]; other site
1229205000254	catalytic residue [active]
1229205000255	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205000256	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205000257	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
1229205000258	putative dimerization interface [polypeptide binding]; other site
1229205000259	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1229205000260	DNA binding residues [nucleotide binding]
1229205000261	dimerization interface [polypeptide binding]; other site
1229205000262	Response regulator receiver domain; Region: Response_reg; pfam00072
1229205000263	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205000264	active site
1229205000265	phosphorylation site [posttranslational modification]
1229205000266	intermolecular recognition site; other site
1229205000267	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229205000268	dimerization interface [polypeptide binding]; other site
1229205000269	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205000270	dimer interface [polypeptide binding]; other site
1229205000271	phosphorylation site [posttranslational modification]
1229205000272	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205000273	ATP binding site [chemical binding]; other site
1229205000274	Mg2+ binding site [ion binding]; other site
1229205000275	G-X-G motif; other site
1229205000276	CheB methylesterase; Region: CheB_methylest; pfam01339
1229205000277	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
1229205000278	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1229205000279	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
1229205000280	CHASE3 domain; Region: CHASE3; pfam05227
1229205000281	GAF domain; Region: GAF; cl17456
1229205000282	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205000283	dimer interface [polypeptide binding]; other site
1229205000284	phosphorylation site [posttranslational modification]
1229205000285	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205000286	ATP binding site [chemical binding]; other site
1229205000287	Mg2+ binding site [ion binding]; other site
1229205000288	G-X-G motif; other site
1229205000289	Response regulator receiver domain; Region: Response_reg; pfam00072
1229205000290	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205000291	active site
1229205000292	phosphorylation site [posttranslational modification]
1229205000293	intermolecular recognition site; other site
1229205000294	dimerization interface [polypeptide binding]; other site
1229205000295	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1229205000296	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205000297	active site
1229205000298	phosphorylation site [posttranslational modification]
1229205000299	intermolecular recognition site; other site
1229205000300	dimerization interface [polypeptide binding]; other site
1229205000301	Response regulator receiver domain; Region: Response_reg; pfam00072
1229205000302	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205000303	active site
1229205000304	phosphorylation site [posttranslational modification]
1229205000305	intermolecular recognition site; other site
1229205000306	dimerization interface [polypeptide binding]; other site
1229205000307	Trehalase; Region: Trehalase; cl17346
1229205000308	MltA-interacting protein MipA; Region: MipA; cl01504
1229205000309	methionine sulfoxide reductase A; Provisional; Region: PRK13014
1229205000310	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
1229205000311	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1229205000312	putative DNA binding site [nucleotide binding]; other site
1229205000313	putative Zn2+ binding site [ion binding]; other site
1229205000314	AsnC family; Region: AsnC_trans_reg; pfam01037
1229205000315	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
1229205000316	Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449
1229205000317	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205000318	catalytic residue [active]
1229205000319	LysR family transcriptional regulator; Provisional; Region: PRK14997
1229205000320	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205000321	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1229205000322	putative effector binding pocket; other site
1229205000323	dimerization interface [polypeptide binding]; other site
1229205000324	Pirin-related protein [General function prediction only]; Region: COG1741
1229205000325	Pirin; Region: Pirin; pfam02678
1229205000326	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
1229205000327	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
1229205000328	catalytic residue [active]
1229205000329	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
1229205000330	catalytic residues [active]
1229205000331	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1229205000332	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1229205000333	peroxiredoxin; Region: AhpC; TIGR03137
1229205000334	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1229205000335	dimer interface [polypeptide binding]; other site
1229205000336	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1229205000337	catalytic triad [active]
1229205000338	peroxidatic and resolving cysteines [active]
1229205000339	Propionate catabolism activator; Region: PrpR_N; pfam06506
1229205000340	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
1229205000341	PAS domain; Region: PAS_8; pfam13188
1229205000342	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205000343	Walker A motif; other site
1229205000344	ATP binding site [chemical binding]; other site
1229205000345	Walker B motif; other site
1229205000346	arginine finger; other site
1229205000347	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1229205000348	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1229205000349	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1229205000350	tetramer interface [polypeptide binding]; other site
1229205000351	active site
1229205000352	Mg2+/Mn2+ binding site [ion binding]; other site
1229205000353	putative transporter; Provisional; Region: PRK10504
1229205000354	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205000355	putative substrate translocation pore; other site
1229205000356	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229205000357	Coenzyme A binding pocket [chemical binding]; other site
1229205000358	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
1229205000359	SnoaL-like domain; Region: SnoaL_2; pfam12680
1229205000360	putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198
1229205000361	pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569
1229205000362	active site
1229205000363	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1229205000364	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205000365	Walker A motif; other site
1229205000366	ATP binding site [chemical binding]; other site
1229205000367	Walker B motif; other site
1229205000368	arginine finger; other site
1229205000369	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1229205000370	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1229205000371	DNA repair helicase (rad3); Region: rad3; TIGR00604
1229205000372	DEAD/DEAH box helicase; Region: DEAD; pfam00270
1229205000373	ATP binding site [chemical binding]; other site
1229205000374	DEAD_2; Region: DEAD_2; pfam06733
1229205000375	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1229205000376	This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990
1229205000377	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
1229205000378	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
1229205000379	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
1229205000380	4Fe-4S binding domain; Region: Fer4; pfam00037
1229205000381	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1229205000382	Cysteine-rich domain; Region: CCG; pfam02754
1229205000383	Cysteine-rich domain; Region: CCG; pfam02754
1229205000384	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1229205000385	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205000386	DNA-binding site [nucleotide binding]; DNA binding site
1229205000387	FCD domain; Region: FCD; pfam07729
1229205000388	aspartate aminotransferase; Provisional; Region: PRK05764
1229205000389	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229205000390	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205000391	homodimer interface [polypeptide binding]; other site
1229205000392	catalytic residue [active]
1229205000393	RNA polymerase factor sigma-54; Provisional; Region: PRK12469
1229205000394	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
1229205000395	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
1229205000396	BON domain; Region: BON; pfam04972
1229205000397	Domain of unknown function (DUF2383); Region: DUF2383; cl17556
1229205000398	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
1229205000399	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
1229205000400	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
1229205000401	intracellular protease, PfpI family; Region: PfpI; TIGR01382
1229205000402	proposed catalytic triad [active]
1229205000403	conserved cys residue [active]
1229205000404	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
1229205000405	DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659
1229205000406	active site
1229205000407	DNA binding site [nucleotide binding]
1229205000408	Int/Topo IB signature motif; other site
1229205000409	catalytic residues [active]
1229205000410	PRC-barrel domain; Region: PRC; pfam05239
1229205000411	Protein of unknown function (DUF3175); Region: DUF3175; pfam11373
1229205000412	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1229205000413	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1229205000414	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1229205000415	Cupin; Region: Cupin_6; pfam12852
1229205000416	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1229205000417	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205000418	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1229205000419	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1229205000420	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1229205000421	active site
1229205000422	catalytic tetrad [active]
1229205000423	Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201
1229205000424	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1229205000425	ATP binding site [chemical binding]; other site
1229205000426	putative Mg++ binding site [ion binding]; other site
1229205000427	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1229205000428	nucleotide binding region [chemical binding]; other site
1229205000429	ATP-binding site [chemical binding]; other site
1229205000430	DEAD/H associated; Region: DEAD_assoc; pfam08494
1229205000431	RNase II stability modulator; Provisional; Region: PRK10060
1229205000432	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1229205000433	putative active site [active]
1229205000434	heme pocket [chemical binding]; other site
1229205000435	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1229205000436	metal binding site [ion binding]; metal-binding site
1229205000437	active site
1229205000438	I-site; other site
1229205000439	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1229205000440	enoyl-CoA hydratase; Validated; Region: PRK08788
1229205000441	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1229205000442	substrate binding site [chemical binding]; other site
1229205000443	oxyanion hole (OAH) forming residues; other site
1229205000444	trimer interface [polypeptide binding]; other site
1229205000445	putative dehydrogenase; Provisional; Region: PRK10098
1229205000446	hypothetical protein; Provisional; Region: PRK07907
1229205000447	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682
1229205000448	metal binding site [ion binding]; metal-binding site
1229205000449	putative dimer interface [polypeptide binding]; other site
1229205000450	Superinfection immunity protein; Region: Imm_superinfect; pfam14373
1229205000451	Uncharacterized small protein (DUF2158); Region: DUF2158; pfam09926
1229205000452	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205000453	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205000454	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229205000455	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229205000456	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1229205000457	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1229205000458	tetramer interface [polypeptide binding]; other site
1229205000459	active site
1229205000460	Mg2+/Mn2+ binding site [ion binding]; other site
1229205000461	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
1229205000462	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1229205000463	hypothetical protein; Provisional; Region: PRK07483
1229205000464	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1229205000465	inhibitor-cofactor binding pocket; inhibition site
1229205000466	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205000467	catalytic residue [active]
1229205000468	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1229205000469	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1229205000470	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1229205000471	putative active site [active]
1229205000472	PAS domain; Region: PAS; smart00091
1229205000473	PAS fold; Region: PAS_7; pfam12860
1229205000474	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1229205000475	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1229205000476	metal binding site [ion binding]; metal-binding site
1229205000477	active site
1229205000478	I-site; other site
1229205000479	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
1229205000480	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
1229205000481	rod shape-determining protein MreB; Provisional; Region: PRK13930
1229205000482	MreB and similar proteins; Region: MreB_like; cd10225
1229205000483	nucleotide binding site [chemical binding]; other site
1229205000484	Mg binding site [ion binding]; other site
1229205000485	putative protofilament interaction site [polypeptide binding]; other site
1229205000486	RodZ interaction site [polypeptide binding]; other site
1229205000487	putative hydrolase; Provisional; Region: PRK11460
1229205000488	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
1229205000489	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1229205000490	DNA binding site [nucleotide binding]
1229205000491	active site
1229205000492	Int/Topo IB signature motif; other site
1229205000493	PAAR motif; Region: PAAR_motif; pfam05488
1229205000494	Rhs element Vgr protein; Region: vgr_GE; TIGR01646
1229205000495	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
1229205000496	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
1229205000497	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
1229205000498	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
1229205000499	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1229205000500	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205000501	putative substrate translocation pore; other site
1229205000502	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205000503	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
1229205000504	glutaminase; Provisional; Region: PRK00971
1229205000505	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1229205000506	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1229205000507	glutaminase active site [active]
1229205000508	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1229205000509	dimer interface [polypeptide binding]; other site
1229205000510	active site
1229205000511	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1229205000512	dimer interface [polypeptide binding]; other site
1229205000513	active site
1229205000514	Haloacid Dehalogenase Superfamily Class (subfamily) IIA; Region: HAD-SF-IIA; TIGR01460
1229205000515	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1229205000516	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205000517	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205000518	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1229205000519	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1229205000520	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205000521	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205000522	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1229205000523	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
1229205000524	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1229205000525	active site
1229205000526	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205000527	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205000528	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1229205000529	dimerization interface [polypeptide binding]; other site
1229205000530	metabolite-proton symporter; Region: 2A0106; TIGR00883
1229205000531	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1229205000532	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1229205000533	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1229205000534	enoyl-CoA hydratase; Provisional; Region: PRK06688
1229205000535	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1229205000536	substrate binding site [chemical binding]; other site
1229205000537	oxyanion hole (OAH) forming residues; other site
1229205000538	trimer interface [polypeptide binding]; other site
1229205000539	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1229205000540	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1229205000541	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
1229205000542	acyl-activating enzyme (AAE) consensus motif; other site
1229205000543	acyl-activating enzyme (AAE) consensus motif; other site
1229205000544	putative AMP binding site [chemical binding]; other site
1229205000545	putative active site [active]
1229205000546	putative CoA binding site [chemical binding]; other site
1229205000547	4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193
1229205000548	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1229205000549	catalytic loop [active]
1229205000550	iron binding site [ion binding]; other site
1229205000551	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1229205000552	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
1229205000553	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
1229205000554	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1229205000555	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1229205000556	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1229205000557	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
1229205000558	putative hydrophobic ligand binding site [chemical binding]; other site
1229205000559	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
1229205000560	Flavoprotein; Region: Flavoprotein; pfam02441
1229205000561	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977
1229205000562	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205000563	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205000564	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1229205000565	dimerization interface [polypeptide binding]; other site
1229205000566	acetylornithine deacetylase; Provisional; Region: PRK07522
1229205000567	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
1229205000568	metal binding site [ion binding]; metal-binding site
1229205000569	putative dimer interface [polypeptide binding]; other site
1229205000570	Uncharacterized conserved protein [Function unknown]; Region: COG3342
1229205000571	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
1229205000572	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1229205000573	homotrimer interaction site [polypeptide binding]; other site
1229205000574	putative active site [active]
1229205000575	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
1229205000576	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1229205000577	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205000578	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205000579	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
1229205000580	putative substrate binding pocket [chemical binding]; other site
1229205000581	dimerization interface [polypeptide binding]; other site
1229205000582	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1229205000583	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1229205000584	[2Fe-2S] cluster binding site [ion binding]; other site
1229205000585	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885
1229205000586	putative alpha subunit interface [polypeptide binding]; other site
1229205000587	putative active site [active]
1229205000588	putative substrate binding site [chemical binding]; other site
1229205000589	Fe binding site [ion binding]; other site
1229205000590	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1229205000591	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
1229205000592	Walker A/P-loop; other site
1229205000593	ATP binding site [chemical binding]; other site
1229205000594	Q-loop/lid; other site
1229205000595	ABC transporter signature motif; other site
1229205000596	Walker B; other site
1229205000597	D-loop; other site
1229205000598	H-loop/switch region; other site
1229205000599	TOBE domain; Region: TOBE_2; pfam08402
1229205000600	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1229205000601	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1229205000602	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205000603	dimer interface [polypeptide binding]; other site
1229205000604	conserved gate region; other site
1229205000605	putative PBP binding loops; other site
1229205000606	ABC-ATPase subunit interface; other site
1229205000607	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1229205000608	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205000609	conserved gate region; other site
1229205000610	dimer interface [polypeptide binding]; other site
1229205000611	putative PBP binding loops; other site
1229205000612	ABC-ATPase subunit interface; other site
1229205000613	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205000614	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205000615	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205000616	dimerization interface [polypeptide binding]; other site
1229205000617	hypothetical protein; Provisional; Region: PRK07079
1229205000618	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679
1229205000619	metal binding site [ion binding]; metal-binding site
1229205000620	putative dimer interface [polypeptide binding]; other site
1229205000621	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205000622	metabolite-proton symporter; Region: 2A0106; TIGR00883
1229205000623	putative substrate translocation pore; other site
1229205000624	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1229205000625	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1229205000626	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205000627	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229205000628	putative substrate translocation pore; other site
1229205000629	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1229205000630	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205000631	active site
1229205000632	phosphorylation site [posttranslational modification]
1229205000633	intermolecular recognition site; other site
1229205000634	dimerization interface [polypeptide binding]; other site
1229205000635	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205000636	Walker A motif; other site
1229205000637	ATP binding site [chemical binding]; other site
1229205000638	Walker B motif; other site
1229205000639	arginine finger; other site
1229205000640	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1229205000641	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229205000642	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205000643	dimer interface [polypeptide binding]; other site
1229205000644	phosphorylation site [posttranslational modification]
1229205000645	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205000646	ATP binding site [chemical binding]; other site
1229205000647	Mg2+ binding site [ion binding]; other site
1229205000648	G-X-G motif; other site
1229205000649	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1229205000650	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205000651	dimer interface [polypeptide binding]; other site
1229205000652	phosphorylation site [posttranslational modification]
1229205000653	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205000654	ATP binding site [chemical binding]; other site
1229205000655	Mg2+ binding site [ion binding]; other site
1229205000656	G-X-G motif; other site
1229205000657	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205000658	osmolarity response regulator; Provisional; Region: ompR; PRK09468
1229205000659	active site
1229205000660	phosphorylation site [posttranslational modification]
1229205000661	intermolecular recognition site; other site
1229205000662	dimerization interface [polypeptide binding]; other site
1229205000663	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229205000664	DNA binding site [nucleotide binding]
1229205000665	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1229205000666	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1229205000667	HlyD family secretion protein; Region: HlyD_3; pfam13437
1229205000668	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
1229205000669	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
1229205000670	Predicted transcriptional regulators [Transcription]; Region: COG1695
1229205000671	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1229205000672	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
1229205000673	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
1229205000674	FAD binding pocket [chemical binding]; other site
1229205000675	FAD binding motif [chemical binding]; other site
1229205000676	phosphate binding motif [ion binding]; other site
1229205000677	NAD binding pocket [chemical binding]; other site
1229205000678	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1229205000679	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205000680	putative substrate translocation pore; other site
1229205000681	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
1229205000682	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1229205000683	substrate binding site [chemical binding]; other site
1229205000684	oxyanion hole (OAH) forming residues; other site
1229205000685	trimer interface [polypeptide binding]; other site
1229205000686	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
1229205000687	enoyl-CoA hydratase; Provisional; Region: PRK09076
1229205000688	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1229205000689	substrate binding site [chemical binding]; other site
1229205000690	oxyanion hole (OAH) forming residues; other site
1229205000691	trimer interface [polypeptide binding]; other site
1229205000692	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1229205000693	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
1229205000694	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1229205000695	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
1229205000696	tetrameric interface [polypeptide binding]; other site
1229205000697	NAD binding site [chemical binding]; other site
1229205000698	catalytic residues [active]
1229205000699	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
1229205000700	Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_1; cd05974
1229205000701	active site
1229205000702	acyl-activating enzyme (AAE) consensus motif; other site
1229205000703	putative CoA binding site [chemical binding]; other site
1229205000704	AMP binding site [chemical binding]; other site
1229205000705	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1229205000706	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1229205000707	active site
1229205000708	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205000709	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205000710	trimer interface [polypeptide binding]; other site
1229205000711	eyelet of channel; other site
1229205000712	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1229205000713	Amidohydrolase; Region: Amidohydro_2; pfam04909
1229205000714	3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264
1229205000715	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1229205000716	homotrimer interaction site [polypeptide binding]; other site
1229205000717	putative active site [active]
1229205000718	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1229205000719	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118
1229205000720	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
1229205000721	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
1229205000722	2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216
1229205000723	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
1229205000724	NAD binding site [chemical binding]; other site
1229205000725	catalytic residues [active]
1229205000726	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
1229205000727	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205000728	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205000729	dimerization interface [polypeptide binding]; other site
1229205000730	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1229205000731	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1229205000732	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205000733	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
1229205000734	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
1229205000735	dimer interface [polypeptide binding]; other site
1229205000736	active site residues [active]
1229205000737	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
1229205000738	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
1229205000739	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
1229205000740	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1229205000741	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
1229205000742	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1229205000743	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
1229205000744	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
1229205000745	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205000746	Walker A motif; other site
1229205000747	ATP binding site [chemical binding]; other site
1229205000748	Walker B motif; other site
1229205000749	arginine finger; other site
1229205000750	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1229205000751	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1229205000752	catalytic loop [active]
1229205000753	iron binding site [ion binding]; other site
1229205000754	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
1229205000755	YheO-like PAS domain; Region: PAS_6; pfam08348
1229205000756	HTH domain; Region: HTH_22; pfam13309
1229205000757	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1229205000758	rRNA binding site [nucleotide binding]; other site
1229205000759	predicted 30S ribosome binding site; other site
1229205000760	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
1229205000761	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205000762	active site
1229205000763	phosphorylation site [posttranslational modification]
1229205000764	intermolecular recognition site; other site
1229205000765	dimerization interface [polypeptide binding]; other site
1229205000766	ANTAR domain; Region: ANTAR; pfam03861
1229205000767	NMT1-like family; Region: NMT1_2; pfam13379
1229205000768	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1229205000769	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
1229205000770	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205000771	dimer interface [polypeptide binding]; other site
1229205000772	phosphorylation site [posttranslational modification]
1229205000773	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205000774	ATP binding site [chemical binding]; other site
1229205000775	Mg2+ binding site [ion binding]; other site
1229205000776	G-X-G motif; other site
1229205000777	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
1229205000778	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205000779	active site
1229205000780	phosphorylation site [posttranslational modification]
1229205000781	intermolecular recognition site; other site
1229205000782	dimerization interface [polypeptide binding]; other site
1229205000783	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229205000784	DNA binding site [nucleotide binding]
1229205000785	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1229205000786	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1229205000787	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1229205000788	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205000789	dimer interface [polypeptide binding]; other site
1229205000790	conserved gate region; other site
1229205000791	ABC-ATPase subunit interface; other site
1229205000792	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205000793	dimer interface [polypeptide binding]; other site
1229205000794	conserved gate region; other site
1229205000795	putative PBP binding loops; other site
1229205000796	ABC-ATPase subunit interface; other site
1229205000797	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1229205000798	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
1229205000799	Walker A/P-loop; other site
1229205000800	ATP binding site [chemical binding]; other site
1229205000801	Q-loop/lid; other site
1229205000802	ABC transporter signature motif; other site
1229205000803	Walker B; other site
1229205000804	D-loop; other site
1229205000805	H-loop/switch region; other site
1229205000806	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205000807	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205000808	trimer interface [polypeptide binding]; other site
1229205000809	eyelet of channel; other site
1229205000810	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
1229205000811	rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637
1229205000812	ligand binding site [chemical binding]; other site
1229205000813	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1229205000814	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1229205000815	TM-ABC transporter signature motif; other site
1229205000816	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1229205000817	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1229205000818	TM-ABC transporter signature motif; other site
1229205000819	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1229205000820	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1229205000821	Walker A/P-loop; other site
1229205000822	ATP binding site [chemical binding]; other site
1229205000823	Q-loop/lid; other site
1229205000824	ABC transporter signature motif; other site
1229205000825	Walker B; other site
1229205000826	D-loop; other site
1229205000827	H-loop/switch region; other site
1229205000828	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1229205000829	Amidohydrolase; Region: Amidohydro_2; pfam04909
1229205000830	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
1229205000831	Domain of unknown function (DUF718); Region: DUF718; pfam05336
1229205000832	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
1229205000833	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205000834	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
1229205000835	putative dimerization interface [polypeptide binding]; other site
1229205000836	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1229205000837	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205000838	NAD(P) binding site [chemical binding]; other site
1229205000839	active site
1229205000840	L-rhamnonate dehydratase; Provisional; Region: PRK15440
1229205000841	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327
1229205000842	putative active site pocket [active]
1229205000843	putative metal binding site [ion binding]; other site
1229205000844	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1229205000845	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205000846	putative substrate translocation pore; other site
1229205000847	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205000848	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1229205000849	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205000850	NAD(P) binding site [chemical binding]; other site
1229205000851	active site
1229205000852	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205000853	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205000854	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
1229205000855	substrate binding pocket [chemical binding]; other site
1229205000856	dimerization interface [polypeptide binding]; other site
1229205000857	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1229205000858	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1229205000859	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1229205000860	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1229205000861	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1229205000862	active site
1229205000863	metal binding site [ion binding]; metal-binding site
1229205000864	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
1229205000865	active site
1229205000866	catalytic site [active]
1229205000867	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1229205000868	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1229205000869	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
1229205000870	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1229205000871	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1229205000872	shikimate binding site; other site
1229205000873	NAD(P) binding site [chemical binding]; other site
1229205000874	H-NS histone family; Region: Histone_HNS; pfam00816
1229205000875	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
1229205000876	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1229205000877	Low molecular weight phosphatase family; Region: LMWPc; cl00105
1229205000878	active site
1229205000879	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1229205000880	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
1229205000881	HSP70 interaction site [polypeptide binding]; other site
1229205000882	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1229205000883	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1229205000884	indole acetimide hydrolase; Validated; Region: PRK07488
1229205000885	Amidase; Region: Amidase; cl11426
1229205000886	CDP-diacylglycerol pyrophosphatase; Region: CDH; pfam02611
1229205000887	Sulfatase; Region: Sulfatase; cl17466
1229205000888	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205000889	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205000890	trimer interface [polypeptide binding]; other site
1229205000891	eyelet of channel; other site
1229205000892	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
1229205000893	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205000894	active site
1229205000895	phosphorylation site [posttranslational modification]
1229205000896	intermolecular recognition site; other site
1229205000897	dimerization interface [polypeptide binding]; other site
1229205000898	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229205000899	DNA binding site [nucleotide binding]
1229205000900	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
1229205000901	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229205000902	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205000903	dimer interface [polypeptide binding]; other site
1229205000904	phosphorylation site [posttranslational modification]
1229205000905	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205000906	ATP binding site [chemical binding]; other site
1229205000907	Mg2+ binding site [ion binding]; other site
1229205000908	G-X-G motif; other site
1229205000909	Uncharacterized conserved protein [Function unknown]; Region: COG3391
1229205000910	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
1229205000911	active site
1229205000912	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1229205000913	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
1229205000914	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
1229205000915	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
1229205000916	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
1229205000917	PAAR motif; Region: PAAR_motif; pfam05488
1229205000918	PAAR motif; Region: PAAR_motif; pfam05488
1229205000919	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
1229205000920	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
1229205000921	hypothetical protein; Validated; Region: PRK08238
1229205000922	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
1229205000923	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
1229205000924	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1229205000925	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
1229205000926	putative di-iron ligands [ion binding]; other site
1229205000927	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205000928	C factor cell-cell signaling protein; Provisional; Region: PRK09009
1229205000929	NAD(P) binding site [chemical binding]; other site
1229205000930	active site
1229205000931	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205000932	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205000933	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
1229205000934	putative substrate binding pocket [chemical binding]; other site
1229205000935	putative dimerization interface [polypeptide binding]; other site
1229205000936	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
1229205000937	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205000938	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205000939	dimerization interface [polypeptide binding]; other site
1229205000940	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1229205000941	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1229205000942	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1229205000943	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229205000944	Walker A/P-loop; other site
1229205000945	ATP binding site [chemical binding]; other site
1229205000946	Q-loop/lid; other site
1229205000947	ABC transporter signature motif; other site
1229205000948	Walker B; other site
1229205000949	D-loop; other site
1229205000950	H-loop/switch region; other site
1229205000951	TOBE domain; Region: TOBE_2; pfam08402
1229205000952	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205000953	dimer interface [polypeptide binding]; other site
1229205000954	conserved gate region; other site
1229205000955	putative PBP binding loops; other site
1229205000956	ABC-ATPase subunit interface; other site
1229205000957	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1229205000958	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205000959	dimer interface [polypeptide binding]; other site
1229205000960	conserved gate region; other site
1229205000961	putative PBP binding loops; other site
1229205000962	ABC-ATPase subunit interface; other site
1229205000963	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1229205000964	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1229205000965	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
1229205000966	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1229205000967	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1229205000968	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1229205000969	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
1229205000970	homotrimer interaction site [polypeptide binding]; other site
1229205000971	putative active site [active]
1229205000972	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
1229205000973	MgtC family; Region: MgtC; pfam02308
1229205000974	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
1229205000975	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1229205000976	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1229205000977	DNA binding residues [nucleotide binding]
1229205000978	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205000979	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205000980	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1229205000981	putative effector binding pocket; other site
1229205000982	dimerization interface [polypeptide binding]; other site
1229205000983	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205000984	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1229205000985	NAD(P) binding site [chemical binding]; other site
1229205000986	active site
1229205000987	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1229205000988	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1229205000989	metal binding site [ion binding]; metal-binding site
1229205000990	active site
1229205000991	I-site; other site
1229205000992	Tannase and feruloyl esterase; Region: Tannase; pfam07519
1229205000993	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205000994	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205000995	trimer interface [polypeptide binding]; other site
1229205000996	eyelet of channel; other site
1229205000997	putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551
1229205000998	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205000999	putative substrate translocation pore; other site
1229205001000	p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120
1229205001001	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1229205001002	substrate binding site [chemical binding]; other site
1229205001003	oxyanion hole (OAH) forming residues; other site
1229205001004	trimer interface [polypeptide binding]; other site
1229205001005	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1229205001006	Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105
1229205001007	NAD(P) binding site [chemical binding]; other site
1229205001008	catalytic residues [active]
1229205001009	feruloyl-CoA synthase; Reviewed; Region: PRK08180
1229205001010	Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921
1229205001011	acyl-activating enzyme (AAE) consensus motif; other site
1229205001012	putative AMP binding site [chemical binding]; other site
1229205001013	putative active site [active]
1229205001014	putative CoA binding site [chemical binding]; other site
1229205001015	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
1229205001016	Isochorismatase family; Region: Isochorismatase; pfam00857
1229205001017	catalytic triad [active]
1229205001018	dimer interface [polypeptide binding]; other site
1229205001019	conserved cis-peptide bond; other site
1229205001020	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1229205001021	MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417
1229205001022	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229205001023	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205001024	dimer interface [polypeptide binding]; other site
1229205001025	phosphorylation site [posttranslational modification]
1229205001026	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205001027	ATP binding site [chemical binding]; other site
1229205001028	G-X-G motif; other site
1229205001029	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205001030	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1229205001031	active site
1229205001032	phosphorylation site [posttranslational modification]
1229205001033	intermolecular recognition site; other site
1229205001034	dimerization interface [polypeptide binding]; other site
1229205001035	TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305
1229205001036	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1229205001037	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1229205001038	active site
1229205001039	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1229205001040	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1229205001041	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1229205001042	catalytic site [active]
1229205001043	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205001044	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205001045	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205001046	dimerization interface [polypeptide binding]; other site
1229205001047	ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360
1229205001048	ATP adenylyltransferase; Region: ATP_transf; pfam09830
1229205001049	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1229205001050	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1229205001051	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1229205001052	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229205001053	substrate binding pocket [chemical binding]; other site
1229205001054	membrane-bound complex binding site; other site
1229205001055	hinge residues; other site
1229205001056	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
1229205001057	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
1229205001058	von Willebrand factor type A domain; Region: VWA_2; pfam13519
1229205001059	metal ion-dependent adhesion site (MIDAS); other site
1229205001060	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229205001061	binding surface
1229205001062	TPR motif; other site
1229205001063	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1229205001064	metal ion-dependent adhesion site (MIDAS); other site
1229205001065	Protein of unknown function DUF58; Region: DUF58; pfam01882
1229205001066	MoxR-like ATPases [General function prediction only]; Region: COG0714
1229205001067	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1229205001068	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205001069	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205001070	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
1229205001071	putative dimerization interface [polypeptide binding]; other site
1229205001072	quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871
1229205001073	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229205001074	membrane-bound complex binding site; other site
1229205001075	hinge residues; other site
1229205001076	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1229205001077	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
1229205001078	Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278
1229205001079	Trp docking motif [polypeptide binding]; other site
1229205001080	dimer interface [polypeptide binding]; other site
1229205001081	active site
1229205001082	small subunit binding site [polypeptide binding]; other site
1229205001083	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
1229205001084	aromatic arch; other site
1229205001085	DCoH dimer interaction site [polypeptide binding]; other site
1229205001086	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
1229205001087	DCoH tetramer interaction site [polypeptide binding]; other site
1229205001088	substrate binding site [chemical binding]; other site
1229205001089	Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907
1229205001090	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1229205001091	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176
1229205001092	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
1229205001093	NAD(P) binding pocket [chemical binding]; other site
1229205001094	Predicted ATP-dependent carboligase related to biotin carboxylase [General function prediction only]; Region: COG2232
1229205001095	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1229205001096	N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264
1229205001097	Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria.  It catalyzes the reversible formation of N(5), N...; Region: MCH; cd00545
1229205001098	trimer interface I [polypeptide binding]; other site
1229205001099	putative substrate binding pocket [chemical binding]; other site
1229205001100	trimer interface II [polypeptide binding]; other site
1229205001101	alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768
1229205001102	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1229205001103	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874
1229205001104	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768
1229205001105	Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714
1229205001106	Dihydroneopterin aldolase; Region: FolB; smart00905
1229205001107	active site
1229205001108	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
1229205001109	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205001110	Walker A motif; other site
1229205001111	ATP binding site [chemical binding]; other site
1229205001112	Walker B motif; other site
1229205001113	arginine finger; other site
1229205001114	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1229205001115	Archaeal flavoproteins [Energy production and conversion]; Region: COG1036
1229205001116	Flavoprotein; Region: Flavoprotein; cl08021
1229205001117	dihydropteroate synthase-related protein; Region: TIGR00284
1229205001118	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
1229205001119	substrate binding pocket [chemical binding]; other site
1229205001120	dimer interface [polypeptide binding]; other site
1229205001121	inhibitor binding site; inhibition site
1229205001122	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1229205001123	intersubunit interface [polypeptide binding]; other site
1229205001124	active site
1229205001125	zinc binding site [ion binding]; other site
1229205001126	Na+ binding site [ion binding]; other site
1229205001127	transketolase; Reviewed; Region: PRK12753
1229205001128	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1229205001129	TPP-binding site [chemical binding]; other site
1229205001130	dimer interface [polypeptide binding]; other site
1229205001131	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1229205001132	PYR/PP interface [polypeptide binding]; other site
1229205001133	dimer interface [polypeptide binding]; other site
1229205001134	TPP binding site [chemical binding]; other site
1229205001135	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1229205001136	phosphoribulokinase; Provisional; Region: PRK15453
1229205001137	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
1229205001138	AMP binding site [chemical binding]; other site
1229205001139	metal binding site [ion binding]; metal-binding site
1229205001140	active site
1229205001141	probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880
1229205001142	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205001143	Walker A motif; other site
1229205001144	ATP binding site [chemical binding]; other site
1229205001145	Walker B motif; other site
1229205001146	arginine finger; other site
1229205001147	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
1229205001148	multimerization interface [polypeptide binding]; other site
1229205001149	ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208
1229205001150	Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212
1229205001151	homodimer interface [polypeptide binding]; other site
1229205001152	active site
1229205001153	heterodimer interface [polypeptide binding]; other site
1229205001154	catalytic residue [active]
1229205001155	metal binding site [ion binding]; metal-binding site
1229205001156	Protein of unknown function (DUF447); Region: DUF447; pfam04289
1229205001157	hypothetical protein; Provisional; Region: PRK02227
1229205001158	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
1229205001159	nucleotide binding site [chemical binding]; other site
1229205001160	substrate binding site [chemical binding]; other site
1229205001161	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1229205001162	nucleotide binding site [chemical binding]; other site
1229205001163	Predicted ATP-utilizing enzyme (ATP-grasp superfamily) [General function prediction only]; Region: COG1821
1229205001164	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1229205001165	hisA/hisF family protein; Region: hisAF_rel; TIGR00734
1229205001166	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723
1229205001167	active site
1229205001168	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1229205001169	formylmethanofuran dehydrogenase subunit B; Region: one_C_dehyd_B; TIGR03129
1229205001170	molybdopterin cofactor binding site; other site
1229205001171	formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121
1229205001172	Formylmethanofuran dehydrogenase (FMDH) subunit A; Methanogenic bacteria and archea derive the energy for autotrophic growth from methanogenesis, the reduction of CO2 with molecular hydrogen as the electron donor. FMDH catalyzes the first step in...; Region: FMDH_A; cd01304
1229205001173	active site
1229205001174	formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114
1229205001175	Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913
1229205001176	FTR, proximal lobe; Region: FTR_C; pfam02741
1229205001177	FwdC/FmdC. This domain of unknown function is found in the subunit C of formylmethanofuran dehydrogenase, an enzyme that catalyzes the first step in methane formation from CO2 in methanogenic archaea, hyperthermophiles and bacteria. There are two...; Region: FwdC/FmdC; cd00980
1229205001178	putative subunit interface; other site
1229205001179	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
1229205001180	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
1229205001181	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
1229205001182	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
1229205001183	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
1229205001184	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
1229205001185	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
1229205001186	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1229205001187	FeS/SAM binding site; other site
1229205001188	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1229205001189	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1229205001190	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205001191	active site
1229205001192	phosphorylation site [posttranslational modification]
1229205001193	intermolecular recognition site; other site
1229205001194	dimerization interface [polypeptide binding]; other site
1229205001195	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1229205001196	DNA binding residues [nucleotide binding]
1229205001197	dimerization interface [polypeptide binding]; other site
1229205001198	Histidine kinase; Region: HisKA_3; pfam07730
1229205001199	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205001200	ATP binding site [chemical binding]; other site
1229205001201	Mg2+ binding site [ion binding]; other site
1229205001202	G-X-G motif; other site
1229205001203	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1229205001204	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1229205001205	N-terminal plug; other site
1229205001206	ligand-binding site [chemical binding]; other site
1229205001207	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
1229205001208	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1229205001209	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
1229205001210	structural tetrad; other site
1229205001211	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
1229205001212	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
1229205001213	phosphoglycolate phosphatase; Provisional; Region: PRK13222
1229205001214	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229205001215	motif II; other site
1229205001216	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205001217	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205001218	trimer interface [polypeptide binding]; other site
1229205001219	eyelet of channel; other site
1229205001220	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
1229205001221	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
1229205001222	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
1229205001223	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1229205001224	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1229205001225	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1229205001226	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1229205001227	carboxyltransferase (CT) interaction site; other site
1229205001228	biotinylation site [posttranslational modification]; other site
1229205001229	enoyl-CoA hydratase; Provisional; Region: PRK05995
1229205001230	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1229205001231	substrate binding site [chemical binding]; other site
1229205001232	oxyanion hole (OAH) forming residues; other site
1229205001233	trimer interface [polypeptide binding]; other site
1229205001234	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
1229205001235	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1229205001236	isovaleryl-CoA dehydrogenase; Region: PLN02519
1229205001237	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
1229205001238	substrate binding site [chemical binding]; other site
1229205001239	FAD binding site [chemical binding]; other site
1229205001240	catalytic base [active]
1229205001241	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229205001242	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229205001243	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
1229205001244	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1229205001245	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
1229205001246	Cl- selectivity filter; other site
1229205001247	Cl- binding residues [ion binding]; other site
1229205001248	pore gating glutamate residue; other site
1229205001249	dimer interface [polypeptide binding]; other site
1229205001250	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1229205001251	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1229205001252	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1229205001253	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1229205001254	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1229205001255	thiamine pyrophosphate protein; Provisional; Region: PRK08273
1229205001256	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1229205001257	PYR/PP interface [polypeptide binding]; other site
1229205001258	dimer interface [polypeptide binding]; other site
1229205001259	tetramer interface [polypeptide binding]; other site
1229205001260	TPP binding site [chemical binding]; other site
1229205001261	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1229205001262	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1229205001263	TPP-binding site [chemical binding]; other site
1229205001264	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_3; cd03328
1229205001265	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1229205001266	putative active site pocket [active]
1229205001267	putative metal binding site [ion binding]; other site
1229205001268	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
1229205001269	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1229205001270	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1229205001271	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1229205001272	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1229205001273	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
1229205001274	putative NAD(P) binding site [chemical binding]; other site
1229205001275	active site
1229205001276	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
1229205001277	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
1229205001278	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1229205001279	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1229205001280	Cytochrome c; Region: Cytochrom_C; pfam00034
1229205001281	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1229205001282	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1229205001283	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1229205001284	Nucleolar protein 12 (25kDa); Region: Nop25; pfam09805
1229205001285	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1229205001286	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1229205001287	D-pathway; other site
1229205001288	Putative ubiquinol binding site [chemical binding]; other site
1229205001289	Low-spin heme (heme b) binding site [chemical binding]; other site
1229205001290	Putative water exit pathway; other site
1229205001291	Binuclear center (heme o3/CuB) [ion binding]; other site
1229205001292	K-pathway; other site
1229205001293	Putative proton exit pathway; other site
1229205001294	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
1229205001295	Subunit I/III interface [polypeptide binding]; other site
1229205001296	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
1229205001297	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1229205001298	Cytochrome c; Region: Cytochrom_C; pfam00034
1229205001299	Domain of unknown function (DUF4396); Region: DUF4396; pfam14342
1229205001300	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
1229205001301	Paraquat-inducible protein A; Region: PqiA; pfam04403
1229205001302	Paraquat-inducible protein A; Region: PqiA; pfam04403
1229205001303	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
1229205001304	Protein of unknown function (DUF330); Region: DUF330; pfam03886
1229205001305	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
1229205001306	PAS domain S-box; Region: sensory_box; TIGR00229
1229205001307	PAS domain; Region: PAS; smart00091
1229205001308	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1229205001309	PAS domain; Region: PAS_9; pfam13426
1229205001310	putative active site [active]
1229205001311	heme pocket [chemical binding]; other site
1229205001312	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1229205001313	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1229205001314	metal binding site [ion binding]; metal-binding site
1229205001315	active site
1229205001316	I-site; other site
1229205001317	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1229205001318	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
1229205001319	VPS10 domain; Region: VPS10; smart00602
1229205001320	Ubiquitin-like proteins; Region: UBQ; cl00155
1229205001321	charged pocket; other site
1229205001322	hydrophobic patch; other site
1229205001323	LysR family transcriptional regulator; Provisional; Region: PRK14997
1229205001324	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205001325	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1229205001326	putative effector binding pocket; other site
1229205001327	dimerization interface [polypeptide binding]; other site
1229205001328	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1229205001329	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205001330	NAD(P) binding site [chemical binding]; other site
1229205001331	active site
1229205001332	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205001333	putative substrate translocation pore; other site
1229205001334	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205001335	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205001336	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
1229205001337	putative effector binding pocket; other site
1229205001338	putative dimerization interface [polypeptide binding]; other site
1229205001339	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229205001340	S-adenosylmethionine binding site [chemical binding]; other site
1229205001341	HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401
1229205001342	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1229205001343	FMN binding site [chemical binding]; other site
1229205001344	dimer interface [polypeptide binding]; other site
1229205001345	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205001346	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205001347	trimer interface [polypeptide binding]; other site
1229205001348	eyelet of channel; other site
1229205001349	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205001350	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205001351	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205001352	The C-terminal substrate binding domain of LysR-type transcriptional regulator PnbR, which is involved in regulating the pnb genes encoding enzymes for 4-nitrobenzoate catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_PnbR; cd08469
1229205001353	putative substrate binding pocket [chemical binding]; other site
1229205001354	putative dimerization interface [polypeptide binding]; other site
1229205001355	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
1229205001356	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1229205001357	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1229205001358	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1229205001359	catalytic loop [active]
1229205001360	iron binding site [ion binding]; other site
1229205001361	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1229205001362	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1229205001363	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1229205001364	Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479
1229205001365	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1229205001366	C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
1229205001367	alpha subunit interface [polypeptide binding]; other site
1229205001368	active site
1229205001369	substrate binding site [chemical binding]; other site
1229205001370	Fe binding site [ion binding]; other site
1229205001371	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1229205001372	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205001373	DNA-binding site [nucleotide binding]; DNA binding site
1229205001374	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1229205001375	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1229205001376	Zn2+ binding site [ion binding]; other site
1229205001377	Mg2+ binding site [ion binding]; other site
1229205001378	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1229205001379	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205001380	DNA-binding site [nucleotide binding]; DNA binding site
1229205001381	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229205001382	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205001383	homodimer interface [polypeptide binding]; other site
1229205001384	catalytic residue [active]
1229205001385	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
1229205001386	putative FMN binding site [chemical binding]; other site
1229205001387	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205001388	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205001389	The C-terminal substrate binding domain of LysR-type transcriptional regulator PnbR, which is involved in regulating the pnb genes encoding enzymes for 4-nitrobenzoate catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_PnbR; cd08469
1229205001390	putative substrate binding pocket [chemical binding]; other site
1229205001391	putative dimerization interface [polypeptide binding]; other site
1229205001392	Protein of unknown function DUF72; Region: DUF72; pfam01904
1229205001393	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
1229205001394	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1229205001395	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1229205001396	IHF dimer interface [polypeptide binding]; other site
1229205001397	IHF - DNA interface [nucleotide binding]; other site
1229205001398	long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12492
1229205001399	Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001
1229205001400	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1229205001401	metal binding site [ion binding]; metal-binding site
1229205001402	active site
1229205001403	I-site; other site
1229205001404	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1229205001405	Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988
1229205001406	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1229205001407	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205001408	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1229205001409	dimerization interface [polypeptide binding]; other site
1229205001410	substrate binding pocket [chemical binding]; other site
1229205001411	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
1229205001412	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205001413	putative substrate translocation pore; other site
1229205001414	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
1229205001415	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
1229205001416	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205001417	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205001418	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
1229205001419	putative effector binding pocket; other site
1229205001420	putative dimerization interface [polypeptide binding]; other site
1229205001421	Cupin domain; Region: Cupin_2; cl17218
1229205001422	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1229205001423	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
1229205001424	putative NAD(P) binding site [chemical binding]; other site
1229205001425	putative substrate binding site [chemical binding]; other site
1229205001426	catalytic Zn binding site [ion binding]; other site
1229205001427	structural Zn binding site [ion binding]; other site
1229205001428	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1229205001429	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1229205001430	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1229205001431	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1229205001432	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229205001433	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
1229205001434	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1229205001435	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1229205001436	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
1229205001437	Protein of unknown function (DUF2891); Region: DUF2891; pfam11199
1229205001438	PRC-barrel domain; Region: PRC; pfam05239
1229205001439	DNA polymerase II; Reviewed; Region: PRK05762
1229205001440	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
1229205001441	active site
1229205001442	catalytic site [active]
1229205001443	substrate binding site [chemical binding]; other site
1229205001444	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
1229205001445	active site
1229205001446	metal-binding site
1229205001447	Phosphoesterase family; Region: Phosphoesterase; pfam04185
1229205001448	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1229205001449	putative DNA binding site [nucleotide binding]; other site
1229205001450	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
1229205001451	putative hydrophobic ligand binding site [chemical binding]; other site
1229205001452	Uncharacterized conserved protein [Function unknown]; Region: COG5649
1229205001453	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229205001454	TPR repeat; Region: TPR_11; pfam13414
1229205001455	binding surface
1229205001456	TPR motif; other site
1229205001457	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
1229205001458	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229205001459	binding surface
1229205001460	TPR motif; other site
1229205001461	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229205001462	TPR motif; other site
1229205001463	binding surface
1229205001464	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229205001465	binding surface
1229205001466	TPR motif; other site
1229205001467	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1229205001468	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1229205001469	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
1229205001470	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1229205001471	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1229205001472	N-terminal plug; other site
1229205001473	ligand-binding site [chemical binding]; other site
1229205001474	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1229205001475	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1229205001476	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1229205001477	Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; pfam10084
1229205001478	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1229205001479	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
1229205001480	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
1229205001481	catalytic residues [active]
1229205001482	short chain dehydrogenase; Provisional; Region: PRK07109
1229205001483	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
1229205001484	putative NAD(P) binding site [chemical binding]; other site
1229205001485	active site
1229205001486	thiamine pyrophosphate protein; Provisional; Region: PRK08273
1229205001487	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1229205001488	PYR/PP interface [polypeptide binding]; other site
1229205001489	dimer interface [polypeptide binding]; other site
1229205001490	tetramer interface [polypeptide binding]; other site
1229205001491	TPP binding site [chemical binding]; other site
1229205001492	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1229205001493	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1229205001494	TPP-binding site [chemical binding]; other site
1229205001495	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
1229205001496	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1229205001497	substrate binding pocket [chemical binding]; other site
1229205001498	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
1229205001499	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1229205001500	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1229205001501	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1229205001502	glutathionine S-transferase; Provisional; Region: PRK10542
1229205001503	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
1229205001504	C-terminal domain interface [polypeptide binding]; other site
1229205001505	GSH binding site (G-site) [chemical binding]; other site
1229205001506	dimer interface [polypeptide binding]; other site
1229205001507	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
1229205001508	dimer interface [polypeptide binding]; other site
1229205001509	substrate binding pocket (H-site) [chemical binding]; other site
1229205001510	N-terminal domain interface [polypeptide binding]; other site
1229205001511	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
1229205001512	ligand binding site [chemical binding]; other site
1229205001513	HAMP domain; Region: HAMP; pfam00672
1229205001514	dimerization interface [polypeptide binding]; other site
1229205001515	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1229205001516	dimer interface [polypeptide binding]; other site
1229205001517	putative CheW interface [polypeptide binding]; other site
1229205001518	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1229205001519	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1229205001520	ligand binding site [chemical binding]; other site
1229205001521	flexible hinge region; other site
1229205001522	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1229205001523	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1229205001524	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1229205001525	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
1229205001526	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1229205001527	ligand binding site [chemical binding]; other site
1229205001528	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
1229205001529	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
1229205001530	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1229205001531	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1229205001532	ligand binding site [chemical binding]; other site
1229205001533	flexible hinge region; other site
1229205001534	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1229205001535	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205001536	dimer interface [polypeptide binding]; other site
1229205001537	conserved gate region; other site
1229205001538	putative PBP binding loops; other site
1229205001539	ABC-ATPase subunit interface; other site
1229205001540	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1229205001541	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205001542	dimer interface [polypeptide binding]; other site
1229205001543	putative PBP binding loops; other site
1229205001544	ABC-ATPase subunit interface; other site
1229205001545	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1229205001546	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1229205001547	maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000
1229205001548	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1229205001549	Walker A/P-loop; other site
1229205001550	ATP binding site [chemical binding]; other site
1229205001551	Q-loop/lid; other site
1229205001552	ABC transporter signature motif; other site
1229205001553	Walker B; other site
1229205001554	D-loop; other site
1229205001555	H-loop/switch region; other site
1229205001556	TOBE domain; Region: TOBE; pfam03459
1229205001557	TOBE domain; Region: TOBE_2; pfam08402
1229205001558	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1229205001559	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1229205001560	DNA binding site [nucleotide binding]
1229205001561	domain linker motif; other site
1229205001562	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1229205001563	dimerization interface [polypeptide binding]; other site
1229205001564	ligand binding site [chemical binding]; other site
1229205001565	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1229205001566	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
1229205001567	ligand binding site [chemical binding]; other site
1229205001568	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1229205001569	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1229205001570	TM-ABC transporter signature motif; other site
1229205001571	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1229205001572	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1229205001573	Walker A/P-loop; other site
1229205001574	ATP binding site [chemical binding]; other site
1229205001575	Q-loop/lid; other site
1229205001576	ABC transporter signature motif; other site
1229205001577	Walker B; other site
1229205001578	D-loop; other site
1229205001579	H-loop/switch region; other site
1229205001580	MarR family; Region: MarR_2; pfam12802
1229205001581	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1229205001582	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1229205001583	nucleotide binding site [chemical binding]; other site
1229205001584	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1229205001585	Transglycosylase; Region: Transgly; cl17702
1229205001586	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1229205001587	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205001588	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205001589	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
1229205001590	putative dimerization interface [polypeptide binding]; other site
1229205001591	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1229205001592	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1229205001593	inhibitor site; inhibition site
1229205001594	active site
1229205001595	dimer interface [polypeptide binding]; other site
1229205001596	catalytic residue [active]
1229205001597	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1229205001598	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1229205001599	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229205001600	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229205001601	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205001602	D-galactonate transporter; Region: 2A0114; TIGR00893
1229205001603	putative substrate translocation pore; other site
1229205001604	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205001605	shikimate 5-dehydrogenase; Reviewed; Region: PRK12549
1229205001606	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1229205001607	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1229205001608	shikimate binding site; other site
1229205001609	NAD(P) binding site [chemical binding]; other site
1229205001610	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1229205001611	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1229205001612	active site
1229205001613	trimer interface [polypeptide binding]; other site
1229205001614	dimer interface [polypeptide binding]; other site
1229205001615	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1229205001616	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
1229205001617	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
1229205001618	dimer interface [polypeptide binding]; other site
1229205001619	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
1229205001620	active site
1229205001621	Fe binding site [ion binding]; other site
1229205001622	PAS fold; Region: PAS_4; pfam08448
1229205001623	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1229205001624	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205001625	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1229205001626	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1229205001627	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1229205001628	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
1229205001629	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1229205001630	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1229205001631	hydroxyproline-2-epimerase; Provisional; Region: PRK13970
1229205001632	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
1229205001633	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1229205001634	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1229205001635	inhibitor site; inhibition site
1229205001636	active site
1229205001637	dimer interface [polypeptide binding]; other site
1229205001638	catalytic residue [active]
1229205001639	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1229205001640	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205001641	active site
1229205001642	phosphorylation site [posttranslational modification]
1229205001643	intermolecular recognition site; other site
1229205001644	dimerization interface [polypeptide binding]; other site
1229205001645	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229205001646	DNA binding site [nucleotide binding]
1229205001647	metabolite-proton symporter; Region: 2A0106; TIGR00883
1229205001648	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205001649	putative substrate translocation pore; other site
1229205001650	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205001651	putative substrate translocation pore; other site
1229205001652	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205001653	Predicted membrane protein [Function unknown]; Region: COG2259
1229205001654	RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809
1229205001655	SnoaL-like domain; Region: SnoaL_2; pfam12680
1229205001656	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229205001657	non-specific DNA binding site [nucleotide binding]; other site
1229205001658	salt bridge; other site
1229205001659	sequence-specific DNA binding site [nucleotide binding]; other site
1229205001660	Predicted transporter component [General function prediction only]; Region: COG2391
1229205001661	Sulphur transport; Region: Sulf_transp; pfam04143
1229205001662	transcriptional activator FlhD; Provisional; Region: PRK02909
1229205001663	transcriptional activator FlhC; Provisional; Region: PRK12860
1229205001664	manganese transport protein MntH; Reviewed; Region: PRK00701
1229205001665	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1229205001666	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
1229205001667	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1229205001668	Flavin binding site [chemical binding]; other site
1229205001669	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205001670	dimer interface [polypeptide binding]; other site
1229205001671	conserved gate region; other site
1229205001672	ABC-ATPase subunit interface; other site
1229205001673	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
1229205001674	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1229205001675	Walker A/P-loop; other site
1229205001676	ATP binding site [chemical binding]; other site
1229205001677	Q-loop/lid; other site
1229205001678	ABC transporter signature motif; other site
1229205001679	Walker B; other site
1229205001680	D-loop; other site
1229205001681	H-loop/switch region; other site
1229205001682	NIL domain; Region: NIL; cl09633
1229205001683	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1229205001684	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1229205001685	active site
1229205001686	non-prolyl cis peptide bond; other site
1229205001687	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1229205001688	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1229205001689	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
1229205001690	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1229205001691	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1229205001692	HlyD family secretion protein; Region: HlyD_3; pfam13437
1229205001693	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1229205001694	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1229205001695	substrate binding pocket [chemical binding]; other site
1229205001696	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205001697	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205001698	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
1229205001699	putative effector binding pocket; other site
1229205001700	putative dimerization interface [polypeptide binding]; other site
1229205001701	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
1229205001702	Purine nucleoside permease (NUP); Region: NUP; pfam06516
1229205001703	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1229205001704	Cation efflux family; Region: Cation_efflux; pfam01545
1229205001705	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
1229205001706	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839
1229205001707	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1229205001708	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
1229205001709	active site
1229205001710	Zn binding site [ion binding]; other site
1229205001711	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
1229205001712	EamA-like transporter family; Region: EamA; cl17759
1229205001713	4-aminobutyrate aminotransferase; Provisional; Region: PRK07495
1229205001714	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1229205001715	inhibitor-cofactor binding pocket; inhibition site
1229205001716	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205001717	catalytic residue [active]
1229205001718	succinic semialdehyde dehydrogenase; Region: PLN02278
1229205001719	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1229205001720	tetramerization interface [polypeptide binding]; other site
1229205001721	NAD(P) binding site [chemical binding]; other site
1229205001722	catalytic residues [active]
1229205001723	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
1229205001724	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1229205001725	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
1229205001726	conserved cys residue [active]
1229205001727	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205001728	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
1229205001729	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
1229205001730	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
1229205001731	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066
1229205001732	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1229205001733	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1229205001734	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1229205001735	active site
1229205001736	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1229205001737	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1229205001738	active site
1229205001739	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229205001740	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205001741	ATP binding site [chemical binding]; other site
1229205001742	G-X-G motif; other site
1229205001743	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205001744	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1229205001745	active site
1229205001746	phosphorylation site [posttranslational modification]
1229205001747	intermolecular recognition site; other site
1229205001748	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1229205001749	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229205001750	motif II; other site
1229205001751	Protein of unknown function (DUF2894); Region: DUF2894; pfam11445
1229205001752	hypothetical protein; Provisional; Region: PRK09040
1229205001753	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1229205001754	ligand binding site [chemical binding]; other site
1229205001755	Domain of unknown function (DUF802); Region: DUF802; pfam05650
1229205001756	Domain of unknown function (DUF802); Region: DUF802; pfam05650
1229205001757	Protein of unknown function (DUF3348); Region: DUF3348; pfam11828
1229205001758	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1229205001759	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229205001760	non-specific DNA binding site [nucleotide binding]; other site
1229205001761	salt bridge; other site
1229205001762	sequence-specific DNA binding site [nucleotide binding]; other site
1229205001763	Cupin domain; Region: Cupin_2; pfam07883
1229205001764	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205001765	metabolite-proton symporter; Region: 2A0106; TIGR00883
1229205001766	putative substrate translocation pore; other site
1229205001767	amidase; Provisional; Region: PRK07486
1229205001768	Amidase; Region: Amidase; pfam01425
1229205001769	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1229205001770	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1229205001771	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1229205001772	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1229205001773	metal binding site [ion binding]; metal-binding site
1229205001774	active site
1229205001775	I-site; other site
1229205001776	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1229205001777	putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791
1229205001778	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205001779	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205001780	dimerization interface [polypeptide binding]; other site
1229205001781	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1229205001782	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
1229205001783	Na binding site [ion binding]; other site
1229205001784	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
1229205001785	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
1229205001786	Histidine kinase; Region: HisKA_3; pfam07730
1229205001787	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205001788	ATP binding site [chemical binding]; other site
1229205001789	Mg2+ binding site [ion binding]; other site
1229205001790	G-X-G motif; other site
1229205001791	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1229205001792	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205001793	active site
1229205001794	phosphorylation site [posttranslational modification]
1229205001795	intermolecular recognition site; other site
1229205001796	dimerization interface [polypeptide binding]; other site
1229205001797	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1229205001798	DNA binding residues [nucleotide binding]
1229205001799	dimerization interface [polypeptide binding]; other site
1229205001800	H-NS histone family; Region: Histone_HNS; pfam00816
1229205001801	H-NS histone family; Region: Histone_HNS; pfam00816
1229205001802	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
1229205001803	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
1229205001804	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1229205001805	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
1229205001806	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1229205001807	active site
1229205001808	catalytic triad [active]
1229205001809	dimer interface [polypeptide binding]; other site
1229205001810	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
1229205001811	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1229205001812	ATP binding site [chemical binding]; other site
1229205001813	putative Mg++ binding site [ion binding]; other site
1229205001814	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1229205001815	nucleotide binding region [chemical binding]; other site
1229205001816	ATP-binding site [chemical binding]; other site
1229205001817	DEAD/H associated; Region: DEAD_assoc; pfam08494
1229205001818	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
1229205001819	putative active site [active]
1229205001820	putative metal binding site [ion binding]; other site
1229205001821	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1229205001822	FAD binding domain; Region: FAD_binding_4; pfam01565
1229205001823	Berberine and berberine like; Region: BBE; pfam08031
1229205001824	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
1229205001825	PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function.  The YbaK-like domain family includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939
1229205001826	putative deacylase active site [active]
1229205001827	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
1229205001828	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205001829	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205001830	trimer interface [polypeptide binding]; other site
1229205001831	eyelet of channel; other site
1229205001832	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
1229205001833	Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765
1229205001834	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1229205001835	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
1229205001836	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1229205001837	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
1229205001838	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
1229205001839	Uncharacterized conserved protein [Function unknown]; Region: COG2308
1229205001840	IHF dimer interface [polypeptide binding]; other site
1229205001841	Bacterial DNA-binding protein; Region: Bac_DNA_binding; pfam00216
1229205001842	IHF - DNA interface [nucleotide binding]; other site
1229205001843	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1229205001844	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205001845	DNA-binding site [nucleotide binding]; DNA binding site
1229205001846	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229205001847	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205001848	homodimer interface [polypeptide binding]; other site
1229205001849	catalytic residue [active]
1229205001850	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
1229205001851	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229205001852	non-specific DNA binding site [nucleotide binding]; other site
1229205001853	salt bridge; other site
1229205001854	sequence-specific DNA binding site [nucleotide binding]; other site
1229205001855	Cupin domain; Region: Cupin_2; pfam07883
1229205001856	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
1229205001857	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1229205001858	peptide binding site [polypeptide binding]; other site
1229205001859	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
1229205001860	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205001861	dimer interface [polypeptide binding]; other site
1229205001862	conserved gate region; other site
1229205001863	putative PBP binding loops; other site
1229205001864	ABC-ATPase subunit interface; other site
1229205001865	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1229205001866	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205001867	dimer interface [polypeptide binding]; other site
1229205001868	conserved gate region; other site
1229205001869	putative PBP binding loops; other site
1229205001870	ABC-ATPase subunit interface; other site
1229205001871	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1229205001872	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1229205001873	Walker A/P-loop; other site
1229205001874	ATP binding site [chemical binding]; other site
1229205001875	Q-loop/lid; other site
1229205001876	ABC transporter signature motif; other site
1229205001877	Walker B; other site
1229205001878	D-loop; other site
1229205001879	H-loop/switch region; other site
1229205001880	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1229205001881	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
1229205001882	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1229205001883	Walker A/P-loop; other site
1229205001884	ATP binding site [chemical binding]; other site
1229205001885	Q-loop/lid; other site
1229205001886	ABC transporter signature motif; other site
1229205001887	Walker B; other site
1229205001888	D-loop; other site
1229205001889	H-loop/switch region; other site
1229205001890	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1229205001891	outer membrane porin, OprD family; Region: OprD; pfam03573
1229205001892	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1229205001893	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1229205001894	dimerization interface [polypeptide binding]; other site
1229205001895	putative Zn2+ binding site [ion binding]; other site
1229205001896	putative DNA binding site [nucleotide binding]; other site
1229205001897	Bacterial transcriptional regulator; Region: IclR; pfam01614
1229205001898	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1229205001899	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229205001900	Walker A/P-loop; other site
1229205001901	ATP binding site [chemical binding]; other site
1229205001902	Q-loop/lid; other site
1229205001903	ABC transporter signature motif; other site
1229205001904	Walker B; other site
1229205001905	D-loop; other site
1229205001906	H-loop/switch region; other site
1229205001907	TOBE domain; Region: TOBE_2; pfam08402
1229205001908	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1229205001909	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205001910	dimer interface [polypeptide binding]; other site
1229205001911	conserved gate region; other site
1229205001912	putative PBP binding loops; other site
1229205001913	ABC-ATPase subunit interface; other site
1229205001914	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1229205001915	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205001916	dimer interface [polypeptide binding]; other site
1229205001917	conserved gate region; other site
1229205001918	putative PBP binding loops; other site
1229205001919	ABC-ATPase subunit interface; other site
1229205001920	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
1229205001921	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1229205001922	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1229205001923	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1229205001924	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1229205001925	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1229205001926	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
1229205001927	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1229205001928	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1229205001929	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
1229205001930	active site
1229205001931	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1229205001932	active site
1229205001933	catalytic motif [active]
1229205001934	Zn binding site [ion binding]; other site
1229205001935	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1229205001936	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1229205001937	Nucleoside recognition; Region: Gate; pfam07670
1229205001938	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1229205001939	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1229205001940	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205001941	active site
1229205001942	phosphorylation site [posttranslational modification]
1229205001943	intermolecular recognition site; other site
1229205001944	dimerization interface [polypeptide binding]; other site
1229205001945	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1229205001946	DNA binding residues [nucleotide binding]
1229205001947	dimerization interface [polypeptide binding]; other site
1229205001948	Response regulator receiver domain; Region: Response_reg; pfam00072
1229205001949	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205001950	active site
1229205001951	phosphorylation site [posttranslational modification]
1229205001952	intermolecular recognition site; other site
1229205001953	dimerization interface [polypeptide binding]; other site
1229205001954	PAS domain S-box; Region: sensory_box; TIGR00229
1229205001955	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1229205001956	putative active site [active]
1229205001957	heme pocket [chemical binding]; other site
1229205001958	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1229205001959	Histidine kinase; Region: HisKA_3; pfam07730
1229205001960	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205001961	ATP binding site [chemical binding]; other site
1229205001962	Mg2+ binding site [ion binding]; other site
1229205001963	G-X-G motif; other site
1229205001964	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229205001965	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205001966	dimer interface [polypeptide binding]; other site
1229205001967	phosphorylation site [posttranslational modification]
1229205001968	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205001969	ATP binding site [chemical binding]; other site
1229205001970	G-X-G motif; other site
1229205001971	Response regulator receiver domain; Region: Response_reg; pfam00072
1229205001972	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205001973	active site
1229205001974	phosphorylation site [posttranslational modification]
1229205001975	intermolecular recognition site; other site
1229205001976	dimerization interface [polypeptide binding]; other site
1229205001977	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
1229205001978	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229205001979	S-adenosylmethionine binding site [chemical binding]; other site
1229205001980	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1229205001981	Ligand Binding Site [chemical binding]; other site
1229205001982	Domain of unknown function (DUF1840); Region: DUF1840; pfam08895
1229205001983	CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448
1229205001984	HPP family; Region: HPP; pfam04982
1229205001985	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1229205001986	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600
1229205001987	MarR family; Region: MarR_2; pfam12802
1229205001988	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1229205001989	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
1229205001990	Cl- selectivity filter; other site
1229205001991	Cl- binding residues [ion binding]; other site
1229205001992	pore gating glutamate residue; other site
1229205001993	dimer interface [polypeptide binding]; other site
1229205001994	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
1229205001995	Protein of unknown function, DUF488; Region: DUF488; pfam04343
1229205001996	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1229205001997	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1229205001998	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205001999	putative substrate translocation pore; other site
1229205002000	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
1229205002001	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1229205002002	HlyD family secretion protein; Region: HlyD_3; pfam13437
1229205002003	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1229205002004	MarR family; Region: MarR_2; pfam12802
1229205002005	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1229205002006	MarR family; Region: MarR_2; pfam12802
1229205002007	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1229205002008	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
1229205002009	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1229205002010	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
1229205002011	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
1229205002012	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
1229205002013	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
1229205002014	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1229205002015	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1229205002016	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
1229205002017	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
1229205002018	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
1229205002019	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
1229205002020	Protein of unknown function (DUF3443); Region: DUF3443; pfam11925
1229205002021	Protein of unknown function (DUF2844); Region: DUF2844; pfam11005
1229205002022	Phasin protein; Region: Phasin_2; pfam09361
1229205002023	Domain of unknown function (DUF4410); Region: DUF4410; pfam14366
1229205002024	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1229205002025	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205002026	active site
1229205002027	phosphorylation site [posttranslational modification]
1229205002028	intermolecular recognition site; other site
1229205002029	dimerization interface [polypeptide binding]; other site
1229205002030	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1229205002031	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1229205002032	DNA binding site [nucleotide binding]
1229205002033	domain linker motif; other site
1229205002034	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_4; cd06280
1229205002035	putative dimerization interface [polypeptide binding]; other site
1229205002036	putative ligand binding site [chemical binding]; other site
1229205002037	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1229205002038	active site
1229205002039	phosphorylation site [posttranslational modification]
1229205002040	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1229205002041	dimerization domain swap beta strand [polypeptide binding]; other site
1229205002042	regulatory protein interface [polypeptide binding]; other site
1229205002043	active site
1229205002044	regulatory phosphorylation site [posttranslational modification]; other site
1229205002045	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1229205002046	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1229205002047	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1229205002048	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1229205002049	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1229205002050	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1229205002051	putative substrate binding site [chemical binding]; other site
1229205002052	putative ATP binding site [chemical binding]; other site
1229205002053	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1229205002054	active site
1229205002055	P-loop; other site
1229205002056	phosphorylation site [posttranslational modification]
1229205002057	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1229205002058	active site
1229205002059	P-loop; other site
1229205002060	phosphorylation site [posttranslational modification]
1229205002061	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
1229205002062	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
1229205002063	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1229205002064	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1229205002065	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
1229205002066	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1229205002067	catalytic residues [active]
1229205002068	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
1229205002069	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1229205002070	catalytic residues [active]
1229205002071	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1229205002072	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205002073	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1229205002074	dimerization interface [polypeptide binding]; other site
1229205002075	substrate binding pocket [chemical binding]; other site
1229205002076	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
1229205002077	active site 1 [active]
1229205002078	dimer interface [polypeptide binding]; other site
1229205002079	hexamer interface [polypeptide binding]; other site
1229205002080	active site 2 [active]
1229205002081	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1229205002082	classical (c) SDRs; Region: SDR_c; cd05233
1229205002083	NAD(P) binding site [chemical binding]; other site
1229205002084	active site
1229205002085	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
1229205002086	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229205002087	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1229205002088	dimerization interface [polypeptide binding]; other site
1229205002089	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
1229205002090	dimer interface [polypeptide binding]; other site
1229205002091	phosphorylation site [posttranslational modification]
1229205002092	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205002093	ATP binding site [chemical binding]; other site
1229205002094	Mg2+ binding site [ion binding]; other site
1229205002095	G-X-G motif; other site
1229205002096	osmolarity response regulator; Provisional; Region: ompR; PRK09468
1229205002097	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205002098	active site
1229205002099	phosphorylation site [posttranslational modification]
1229205002100	intermolecular recognition site; other site
1229205002101	dimerization interface [polypeptide binding]; other site
1229205002102	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229205002103	DNA binding site [nucleotide binding]
1229205002104	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1229205002105	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
1229205002106	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
1229205002107	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
1229205002108	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229205002109	S-adenosylmethionine binding site [chemical binding]; other site
1229205002110	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895
1229205002111	putative hydrophobic ligand binding site [chemical binding]; other site
1229205002112	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1229205002113	putative catalytic site [active]
1229205002114	putative metal binding site [ion binding]; other site
1229205002115	putative phosphate binding site [ion binding]; other site
1229205002116	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1229205002117	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
1229205002118	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1229205002119	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296
1229205002120	putative NAD(P) binding site [chemical binding]; other site
1229205002121	putative substrate binding site [chemical binding]; other site
1229205002122	catalytic Zn binding site [ion binding]; other site
1229205002123	structural Zn binding site [ion binding]; other site
1229205002124	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1229205002125	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1229205002126	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205002127	DNA-binding site [nucleotide binding]; DNA binding site
1229205002128	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229205002129	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205002130	homodimer interface [polypeptide binding]; other site
1229205002131	catalytic residue [active]
1229205002132	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
1229205002133	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1229205002134	inhibitor-cofactor binding pocket; inhibition site
1229205002135	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205002136	catalytic residue [active]
1229205002137	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1229205002138	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330
1229205002139	putative ligand binding site [chemical binding]; other site
1229205002140	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1229205002141	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1229205002142	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1229205002143	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1229205002144	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1229205002145	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1229205002146	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
1229205002147	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1229205002148	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1229205002149	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
1229205002150	Amidohydrolase; Region: Amidohydro_5; pfam13594
1229205002151	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
1229205002152	active site
1229205002153	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1229205002154	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1229205002155	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1229205002156	Walker A/P-loop; other site
1229205002157	ATP binding site [chemical binding]; other site
1229205002158	Q-loop/lid; other site
1229205002159	ABC transporter signature motif; other site
1229205002160	Walker B; other site
1229205002161	D-loop; other site
1229205002162	H-loop/switch region; other site
1229205002163	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1229205002164	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1229205002165	Walker A/P-loop; other site
1229205002166	ATP binding site [chemical binding]; other site
1229205002167	Q-loop/lid; other site
1229205002168	ABC transporter signature motif; other site
1229205002169	Walker B; other site
1229205002170	D-loop; other site
1229205002171	H-loop/switch region; other site
1229205002172	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1229205002173	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1229205002174	TM-ABC transporter signature motif; other site
1229205002175	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1229205002176	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1229205002177	TM-ABC transporter signature motif; other site
1229205002178	Amino acid synthesis; Region: AA_synth; pfam06684
1229205002179	Amino acid synthesis; Region: AA_synth; pfam06684
1229205002180	hypothetical protein; Provisional; Region: PRK04334
1229205002181	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229205002182	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229205002183	4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425
1229205002184	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
1229205002185	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053
1229205002186	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
1229205002187	tetramer interface [polypeptide binding]; other site
1229205002188	active site
1229205002189	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
1229205002190	3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429
1229205002191	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205002192	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205002193	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
1229205002194	substrate binding pocket [chemical binding]; other site
1229205002195	dimerization interface [polypeptide binding]; other site
1229205002196	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
1229205002197	GTP cyclohydrolase I; Provisional; Region: PLN03044
1229205002198	active site
1229205002199	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1229205002200	EamA-like transporter family; Region: EamA; pfam00892
1229205002201	EamA-like transporter family; Region: EamA; pfam00892
1229205002202	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1229205002203	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1229205002204	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1229205002205	active site residue [active]
1229205002206	Cache domain; Region: Cache_1; pfam02743
1229205002207	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1229205002208	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1229205002209	metal binding site [ion binding]; metal-binding site
1229205002210	active site
1229205002211	I-site; other site
1229205002212	CHAD domain; Region: CHAD; pfam05235
1229205002213	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1229205002214	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1229205002215	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
1229205002216	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1229205002217	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1229205002218	active site
1229205002219	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1229205002220	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1229205002221	protein binding site [polypeptide binding]; other site
1229205002222	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1229205002223	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1229205002224	hypothetical protein; Provisional; Region: PRK07482
1229205002225	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1229205002226	inhibitor-cofactor binding pocket; inhibition site
1229205002227	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205002228	catalytic residue [active]
1229205002229	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1229205002230	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1229205002231	tetramerization interface [polypeptide binding]; other site
1229205002232	NAD(P) binding site [chemical binding]; other site
1229205002233	catalytic residues [active]
1229205002234	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1229205002235	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1229205002236	putative DNA binding site [nucleotide binding]; other site
1229205002237	putative Zn2+ binding site [ion binding]; other site
1229205002238	AsnC family; Region: AsnC_trans_reg; pfam01037
1229205002239	ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994
1229205002240	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252
1229205002241	putative active site [active]
1229205002242	Zn binding site [ion binding]; other site
1229205002243	ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993
1229205002244	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1229205002245	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
1229205002246	active site
1229205002247	ectoine utilization protein EutC; Validated; Region: PRK08291
1229205002248	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
1229205002249	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
1229205002250	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1229205002251	tetramer interface [polypeptide binding]; other site
1229205002252	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205002253	catalytic residue [active]
1229205002254	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205002255	DNA-binding site [nucleotide binding]; DNA binding site
1229205002256	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1229205002257	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229205002258	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205002259	homodimer interface [polypeptide binding]; other site
1229205002260	catalytic residue [active]
1229205002261	ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995
1229205002262	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229205002263	substrate binding pocket [chemical binding]; other site
1229205002264	membrane-bound complex binding site; other site
1229205002265	hinge residues; other site
1229205002266	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1229205002267	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205002268	dimer interface [polypeptide binding]; other site
1229205002269	conserved gate region; other site
1229205002270	putative PBP binding loops; other site
1229205002271	ABC-ATPase subunit interface; other site
1229205002272	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1229205002273	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205002274	dimer interface [polypeptide binding]; other site
1229205002275	conserved gate region; other site
1229205002276	putative PBP binding loops; other site
1229205002277	ABC-ATPase subunit interface; other site
1229205002278	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1229205002279	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1229205002280	Walker A/P-loop; other site
1229205002281	ATP binding site [chemical binding]; other site
1229205002282	Q-loop/lid; other site
1229205002283	ABC transporter signature motif; other site
1229205002284	Walker B; other site
1229205002285	D-loop; other site
1229205002286	H-loop/switch region; other site
1229205002287	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205002288	putative transporter; Provisional; Region: PRK10504
1229205002289	putative substrate translocation pore; other site
1229205002290	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205002291	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1229205002292	active site
1229205002293	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
1229205002294	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
1229205002295	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
1229205002296	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
1229205002297	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
1229205002298	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1229205002299	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205002300	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1229205002301	serine O-acetyltransferase; Region: cysE; TIGR01172
1229205002302	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1229205002303	trimer interface [polypeptide binding]; other site
1229205002304	active site
1229205002305	substrate binding site [chemical binding]; other site
1229205002306	CoA binding site [chemical binding]; other site
1229205002307	Transcriptional activator HlyU; Region: HlyU; cl02273
1229205002308	Protein of unknown function (DUF3005); Region: DUF3005; pfam11448
1229205002309	short chain dehydrogenase; Provisional; Region: PRK12827
1229205002310	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
1229205002311	putative NAD(P) binding site [chemical binding]; other site
1229205002312	homodimer interface [polypeptide binding]; other site
1229205002313	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1229205002314	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205002315	dimer interface [polypeptide binding]; other site
1229205002316	conserved gate region; other site
1229205002317	putative PBP binding loops; other site
1229205002318	ABC-ATPase subunit interface; other site
1229205002319	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1229205002320	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205002321	dimer interface [polypeptide binding]; other site
1229205002322	conserved gate region; other site
1229205002323	putative PBP binding loops; other site
1229205002324	ABC-ATPase subunit interface; other site
1229205002325	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1229205002326	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229205002327	Walker A/P-loop; other site
1229205002328	ATP binding site [chemical binding]; other site
1229205002329	Q-loop/lid; other site
1229205002330	ABC transporter signature motif; other site
1229205002331	Walker B; other site
1229205002332	D-loop; other site
1229205002333	H-loop/switch region; other site
1229205002334	TOBE domain; Region: TOBE_2; pfam08402
1229205002335	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134
1229205002336	hypothetical protein; Provisional; Region: PRK11622
1229205002337	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
1229205002338	Strictosidine synthase; Region: Str_synth; pfam03088
1229205002339	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1229205002340	inhibitor site; inhibition site
1229205002341	active site
1229205002342	dimer interface [polypeptide binding]; other site
1229205002343	catalytic residue [active]
1229205002344	Autoinducer binding domain; Region: Autoind_bind; pfam03472
1229205002345	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1229205002346	DNA binding residues [nucleotide binding]
1229205002347	dimerization interface [polypeptide binding]; other site
1229205002348	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1229205002349	non-specific DNA binding site [nucleotide binding]; other site
1229205002350	salt bridge; other site
1229205002351	sequence-specific DNA binding site [nucleotide binding]; other site
1229205002352	Autoinducer synthetase; Region: Autoind_synth; cl17404
1229205002353	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1229205002354	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205002355	DNA-binding site [nucleotide binding]; DNA binding site
1229205002356	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1229205002357	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1229205002358	Ligand Binding Site [chemical binding]; other site
1229205002359	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205002360	active site
1229205002361	phosphorylation site [posttranslational modification]
1229205002362	intermolecular recognition site; other site
1229205002363	dimerization interface [polypeptide binding]; other site
1229205002364	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
1229205002365	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1229205002366	TPP-binding site [chemical binding]; other site
1229205002367	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1229205002368	dimer interface [polypeptide binding]; other site
1229205002369	PYR/PP interface [polypeptide binding]; other site
1229205002370	TPP binding site [chemical binding]; other site
1229205002371	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1229205002372	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1229205002373	dimerization interface [polypeptide binding]; other site
1229205002374	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1229205002375	dimer interface [polypeptide binding]; other site
1229205002376	putative CheW interface [polypeptide binding]; other site
1229205002377	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
1229205002378	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1229205002379	ligand binding site [chemical binding]; other site
1229205002380	flexible hinge region; other site
1229205002381	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1229205002382	putative switch regulator; other site
1229205002383	non-specific DNA interactions [nucleotide binding]; other site
1229205002384	DNA binding site [nucleotide binding]
1229205002385	sequence specific DNA binding site [nucleotide binding]; other site
1229205002386	putative cAMP binding site [chemical binding]; other site
1229205002387	5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344
1229205002388	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1229205002389	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1229205002390	ALDH subfamily: NAD(P)+-dependent benzaldehyde dehydrogenase II, vanillin dehydrogenase, p-hydroxybenzaldehyde dehydrogenase and related proteins; Region: ALDH_BenzADH-like; cd07104
1229205002391	NAD(P) binding site [chemical binding]; other site
1229205002392	catalytic residues [active]
1229205002393	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
1229205002394	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205002395	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229205002396	putative substrate translocation pore; other site
1229205002397	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205002398	DNA-binding site [nucleotide binding]; DNA binding site
1229205002399	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1229205002400	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205002401	DNA-binding site [nucleotide binding]; DNA binding site
1229205002402	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1229205002403	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205002404	NAD(P) binding site [chemical binding]; other site
1229205002405	active site
1229205002406	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
1229205002407	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
1229205002408	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1229205002409	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1229205002410	active site
1229205002411	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
1229205002412	Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314
1229205002413	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299
1229205002414	Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105
1229205002415	NAD(P) binding site [chemical binding]; other site
1229205002416	catalytic residues [active]
1229205002417	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1229205002418	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1229205002419	N-terminal domain of 2,4,5-trihydroxytoluene (THT) oxygenase; Region: THT_Oxygenase_N; cd07267
1229205002420	3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295
1229205002421	The C-terminal domain of 2,4,5-Trihydroxytoluene (THT) oxygenase, which is an extradiol dioxygenease in the 2,4-dinitrotoluene (DNT) degradation pathway; Region: THT_oxygenase_C; cd07257
1229205002422	putative active site [active]
1229205002423	putative metal binding site [ion binding]; other site
1229205002424	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1229205002425	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205002426	DNA-binding site [nucleotide binding]; DNA binding site
1229205002427	FCD domain; Region: FCD; pfam07729
1229205002428	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205002429	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229205002430	putative substrate translocation pore; other site
1229205002431	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
1229205002432	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1229205002433	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1229205002434	C-terminal domain of type I, class II extradiol dioxygenases; catalytic domain; Region: ED_TypeI_classII_C; cd08343
1229205002435	active site
1229205002436	metal binding site [ion binding]; metal-binding site
1229205002437	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1229205002438	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1229205002439	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1229205002440	hypothetical protein; Provisional; Region: PRK06194
1229205002441	classical (c) SDRs; Region: SDR_c; cd05233
1229205002442	NAD(P) binding site [chemical binding]; other site
1229205002443	active site
1229205002444	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1229205002445	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205002446	NAD(P) binding site [chemical binding]; other site
1229205002447	active site
1229205002448	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1229205002449	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1229205002450	active site
1229205002451	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
1229205002452	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
1229205002453	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1229205002454	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205002455	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229205002456	putative substrate translocation pore; other site
1229205002457	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
1229205002458	DNA-binding site [nucleotide binding]; DNA binding site
1229205002459	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1229205002460	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1229205002461	ALDH subfamily: NAD(P)+-dependent benzaldehyde dehydrogenase II, vanillin dehydrogenase, p-hydroxybenzaldehyde dehydrogenase and related proteins; Region: ALDH_BenzADH-like; cd07104
1229205002462	NAD(P) binding site [chemical binding]; other site
1229205002463	catalytic residues [active]
1229205002464	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
1229205002465	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
1229205002466	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
1229205002467	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1229205002468	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1229205002469	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1229205002470	putative DNA binding site [nucleotide binding]; other site
1229205002471	putative Zn2+ binding site [ion binding]; other site
1229205002472	AsnC family; Region: AsnC_trans_reg; pfam01037
1229205002473	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
1229205002474	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1229205002475	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205002476	dimer interface [polypeptide binding]; other site
1229205002477	conserved gate region; other site
1229205002478	putative PBP binding loops; other site
1229205002479	ABC-ATPase subunit interface; other site
1229205002480	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
1229205002481	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229205002482	Walker A/P-loop; other site
1229205002483	ATP binding site [chemical binding]; other site
1229205002484	Q-loop/lid; other site
1229205002485	ABC transporter signature motif; other site
1229205002486	Walker B; other site
1229205002487	D-loop; other site
1229205002488	H-loop/switch region; other site
1229205002489	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1229205002490	NIPSNAP; Region: NIPSNAP; pfam07978
1229205002491	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1229205002492	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
1229205002493	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1229205002494	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
1229205002495	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1229205002496	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1229205002497	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
1229205002498	NAD(P) binding site [chemical binding]; other site
1229205002499	catalytic residues [active]
1229205002500	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1229205002501	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1229205002502	nudix motif; other site
1229205002503	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1229205002504	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1229205002505	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1229205002506	Amino acid synthesis; Region: AA_synth; pfam06684
1229205002507	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
1229205002508	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1229205002509	putative ligand binding site [chemical binding]; other site
1229205002510	NAD binding site [chemical binding]; other site
1229205002511	dimerization interface [polypeptide binding]; other site
1229205002512	catalytic site [active]
1229205002513	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
1229205002514	Uncharacterized conserved protein [Function unknown]; Region: COG5476
1229205002515	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
1229205002516	MlrC C-terminus; Region: MlrC_C; pfam07171
1229205002517	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1229205002518	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205002519	putative substrate translocation pore; other site
1229205002520	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205002521	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205002522	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205002523	dimerization interface [polypeptide binding]; other site
1229205002524	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
1229205002525	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
1229205002526	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1229205002527	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1229205002528	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1229205002529	HlyD family secretion protein; Region: HlyD_3; pfam13437
1229205002530	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1229205002531	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
1229205002532	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1229205002533	dimerization interface [polypeptide binding]; other site
1229205002534	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205002535	dimer interface [polypeptide binding]; other site
1229205002536	phosphorylation site [posttranslational modification]
1229205002537	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205002538	ATP binding site [chemical binding]; other site
1229205002539	Mg2+ binding site [ion binding]; other site
1229205002540	G-X-G motif; other site
1229205002541	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
1229205002542	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205002543	active site
1229205002544	phosphorylation site [posttranslational modification]
1229205002545	intermolecular recognition site; other site
1229205002546	dimerization interface [polypeptide binding]; other site
1229205002547	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229205002548	DNA binding site [nucleotide binding]
1229205002549	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229205002550	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205002551	dimer interface [polypeptide binding]; other site
1229205002552	phosphorylation site [posttranslational modification]
1229205002553	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205002554	ATP binding site [chemical binding]; other site
1229205002555	Mg2+ binding site [ion binding]; other site
1229205002556	G-X-G motif; other site
1229205002557	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229205002558	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229205002559	short chain dehydrogenase; Validated; Region: PRK08264
1229205002560	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205002561	NAD(P) binding site [chemical binding]; other site
1229205002562	active site
1229205002563	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
1229205002564	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
1229205002565	Phosphoesterase family; Region: Phosphoesterase; pfam04185
1229205002566	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1229205002567	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
1229205002568	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
1229205002569	active site
1229205002570	substrate binding site [chemical binding]; other site
1229205002571	putative catalytic residues [active]
1229205002572	FMN binding site [chemical binding]; other site
1229205002573	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
1229205002574	2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311
1229205002575	active site
1229205002576	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205002577	putative substrate translocation pore; other site
1229205002578	H+ Antiporter protein; Region: 2A0121; TIGR00900
1229205002579	benzoate transport; Region: 2A0115; TIGR00895
1229205002580	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205002581	putative substrate translocation pore; other site
1229205002582	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
1229205002583	Amidohydrolase; Region: Amidohydro_2; pfam04909
1229205002584	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205002585	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205002586	trimer interface [polypeptide binding]; other site
1229205002587	eyelet of channel; other site
1229205002588	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1229205002589	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205002590	putative substrate translocation pore; other site
1229205002591	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1229205002592	Strictosidine synthase; Region: Str_synth; pfam03088
1229205002593	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1229205002594	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
1229205002595	ligand binding site [chemical binding]; other site
1229205002596	NAD binding site [chemical binding]; other site
1229205002597	dimerization interface [polypeptide binding]; other site
1229205002598	catalytic site [active]
1229205002599	hypothetical protein; Validated; Region: PRK06201
1229205002600	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
1229205002601	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1229205002602	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1229205002603	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1229205002604	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
1229205002605	phosphate binding site [ion binding]; other site
1229205002606	SnoaL-like domain; Region: SnoaL_2; pfam12680
1229205002607	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1229205002608	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205002609	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1229205002610	dimerization interface [polypeptide binding]; other site
1229205002611	substrate binding pocket [chemical binding]; other site
1229205002612	TIGR02594 family protein; Region: TIGR02594
1229205002613	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1229205002614	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685
1229205002615	nudix motif; other site
1229205002616	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229205002617	S-adenosylmethionine binding site [chemical binding]; other site
1229205002618	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
1229205002619	SnoaL-like domain; Region: SnoaL_2; pfam12680
1229205002620	cyanate hydratase; Validated; Region: PRK02866
1229205002621	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
1229205002622	oligomer interface [polypeptide binding]; other site
1229205002623	active site
1229205002624	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
1229205002625	active site clefts [active]
1229205002626	zinc binding site [ion binding]; other site
1229205002627	dimer interface [polypeptide binding]; other site
1229205002628	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
1229205002629	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205002630	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425
1229205002631	dimerization interface [polypeptide binding]; other site
1229205002632	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
1229205002633	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
1229205002634	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1229205002635	Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044
1229205002636	diiron binding motif [ion binding]; other site
1229205002637	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433
1229205002638	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
1229205002639	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1229205002640	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1229205002641	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1229205002642	metal binding site [ion binding]; metal-binding site
1229205002643	active site
1229205002644	I-site; other site
1229205002645	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
1229205002646	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1229205002647	acyl-activating enzyme (AAE) consensus motif; other site
1229205002648	AMP binding site [chemical binding]; other site
1229205002649	active site
1229205002650	CoA binding site [chemical binding]; other site
1229205002651	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1229205002652	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1229205002653	Protein of unknown function (DUF861); Region: Cupin_3; cl17594
1229205002654	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1229205002655	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1229205002656	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205002657	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205002658	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1229205002659	dimerization interface [polypeptide binding]; other site
1229205002660	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
1229205002661	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1229205002662	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
1229205002663	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1229205002664	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1229205002665	dimer interface [polypeptide binding]; other site
1229205002666	putative CheW interface [polypeptide binding]; other site
1229205002667	Cupin; Region: Cupin_6; pfam12852
1229205002668	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1229205002669	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205002670	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1229205002671	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1229205002672	NADP binding site [chemical binding]; other site
1229205002673	active site
1229205002674	steroid binding site; other site
1229205002675	LysR family transcriptional regulator; Provisional; Region: PRK14997
1229205002676	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1229205002677	putative effector binding pocket; other site
1229205002678	dimerization interface [polypeptide binding]; other site
1229205002679	NmrA-like family; Region: NmrA; pfam05368
1229205002680	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
1229205002681	NADP binding site [chemical binding]; other site
1229205002682	active site
1229205002683	regulatory binding site [polypeptide binding]; other site
1229205002684	hypothetical protein; Provisional; Region: PRK05939
1229205002685	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1229205002686	homodimer interface [polypeptide binding]; other site
1229205002687	substrate-cofactor binding pocket; other site
1229205002688	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205002689	catalytic residue [active]
1229205002690	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
1229205002691	Esterase/lipase [General function prediction only]; Region: COG1647
1229205002692	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
1229205002693	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205002694	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205002695	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
1229205002696	putative dimerization interface [polypeptide binding]; other site
1229205002697	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1229205002698	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1229205002699	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1229205002700	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1229205002701	citrate-proton symporter; Provisional; Region: PRK15075
1229205002702	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205002703	putative substrate translocation pore; other site
1229205002704	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1229205002705	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1229205002706	putative active site [active]
1229205002707	heme pocket [chemical binding]; other site
1229205002708	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205002709	dimer interface [polypeptide binding]; other site
1229205002710	phosphorylation site [posttranslational modification]
1229205002711	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205002712	ATP binding site [chemical binding]; other site
1229205002713	Mg2+ binding site [ion binding]; other site
1229205002714	G-X-G motif; other site
1229205002715	Response regulator receiver domain; Region: Response_reg; pfam00072
1229205002716	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205002717	active site
1229205002718	phosphorylation site [posttranslational modification]
1229205002719	intermolecular recognition site; other site
1229205002720	dimerization interface [polypeptide binding]; other site
1229205002721	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1229205002722	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1229205002723	TIGR03118 family protein; Region: PEPCTERM_chp_1
1229205002724	PRC-barrel domain; Region: PRC; pfam05239
1229205002725	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205002726	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205002727	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1229205002728	putative effector binding pocket; other site
1229205002729	dimerization interface [polypeptide binding]; other site
1229205002730	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1229205002731	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205002732	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1229205002733	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1229205002734	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1229205002735	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1229205002736	D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178
1229205002737	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1229205002738	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
1229205002739	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1229205002740	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205002741	dimer interface [polypeptide binding]; other site
1229205002742	conserved gate region; other site
1229205002743	putative PBP binding loops; other site
1229205002744	ABC-ATPase subunit interface; other site
1229205002745	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1229205002746	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1229205002747	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205002748	dimer interface [polypeptide binding]; other site
1229205002749	conserved gate region; other site
1229205002750	putative PBP binding loops; other site
1229205002751	ABC-ATPase subunit interface; other site
1229205002752	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1229205002753	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1229205002754	Walker A/P-loop; other site
1229205002755	ATP binding site [chemical binding]; other site
1229205002756	Q-loop/lid; other site
1229205002757	ABC transporter signature motif; other site
1229205002758	Walker B; other site
1229205002759	D-loop; other site
1229205002760	H-loop/switch region; other site
1229205002761	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1229205002762	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1229205002763	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1229205002764	Walker A/P-loop; other site
1229205002765	ATP binding site [chemical binding]; other site
1229205002766	Q-loop/lid; other site
1229205002767	ABC transporter signature motif; other site
1229205002768	Walker B; other site
1229205002769	D-loop; other site
1229205002770	H-loop/switch region; other site
1229205002771	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1229205002772	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1229205002773	dimerization interface [polypeptide binding]; other site
1229205002774	ligand binding site [chemical binding]; other site
1229205002775	Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488
1229205002776	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
1229205002777	CheB methylesterase; Region: CheB_methylest; pfam01339
1229205002778	CheB methylesterase; Region: CheB_methylest; pfam01339
1229205002779	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
1229205002780	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1229205002781	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229205002782	S-adenosylmethionine binding site [chemical binding]; other site
1229205002783	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1229205002784	PAS domain; Region: PAS_9; pfam13426
1229205002785	putative active site [active]
1229205002786	heme pocket [chemical binding]; other site
1229205002787	PAS domain; Region: PAS_10; pfam13596
1229205002788	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1229205002789	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1229205002790	putative active site [active]
1229205002791	heme pocket [chemical binding]; other site
1229205002792	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205002793	dimer interface [polypeptide binding]; other site
1229205002794	phosphorylation site [posttranslational modification]
1229205002795	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205002796	ATP binding site [chemical binding]; other site
1229205002797	Mg2+ binding site [ion binding]; other site
1229205002798	G-X-G motif; other site
1229205002799	Response regulator receiver domain; Region: Response_reg; pfam00072
1229205002800	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205002801	active site
1229205002802	phosphorylation site [posttranslational modification]
1229205002803	intermolecular recognition site; other site
1229205002804	dimerization interface [polypeptide binding]; other site
1229205002805	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205002806	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205002807	trimer interface [polypeptide binding]; other site
1229205002808	eyelet of channel; other site
1229205002809	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
1229205002810	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
1229205002811	active site
1229205002812	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229205002813	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205002814	ATP binding site [chemical binding]; other site
1229205002815	Mg2+ binding site [ion binding]; other site
1229205002816	G-X-G motif; other site
1229205002817	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1229205002818	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205002819	active site
1229205002820	phosphorylation site [posttranslational modification]
1229205002821	intermolecular recognition site; other site
1229205002822	dimerization interface [polypeptide binding]; other site
1229205002823	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1229205002824	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205002825	active site
1229205002826	phosphorylation site [posttranslational modification]
1229205002827	intermolecular recognition site; other site
1229205002828	dimerization interface [polypeptide binding]; other site
1229205002829	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229205002830	Coenzyme A binding pocket [chemical binding]; other site
1229205002831	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
1229205002832	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
1229205002833	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1229205002834	active site
1229205002835	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
1229205002836	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
1229205002837	Surface antigen; Region: Bac_surface_Ag; pfam01103
1229205002838	haemagglutination activity domain; Region: Haemagg_act; smart00912
1229205002839	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1229205002840	PAS domain; Region: PAS_9; pfam13426
1229205002841	putative active site [active]
1229205002842	heme pocket [chemical binding]; other site
1229205002843	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1229205002844	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1229205002845	putative active site [active]
1229205002846	heme pocket [chemical binding]; other site
1229205002847	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1229205002848	heme pocket [chemical binding]; other site
1229205002849	putative active site [active]
1229205002850	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
1229205002851	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229205002852	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205002853	dimer interface [polypeptide binding]; other site
1229205002854	phosphorylation site [posttranslational modification]
1229205002855	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205002856	ATP binding site [chemical binding]; other site
1229205002857	Mg2+ binding site [ion binding]; other site
1229205002858	G-X-G motif; other site
1229205002859	Response regulator receiver domain; Region: Response_reg; pfam00072
1229205002860	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205002861	active site
1229205002862	phosphorylation site [posttranslational modification]
1229205002863	intermolecular recognition site; other site
1229205002864	dimerization interface [polypeptide binding]; other site
1229205002865	potassium-tellurite ethidium and proflavin transporter; Provisional; Region: PRK10764
1229205002866	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
1229205002867	gating phenylalanine in ion channel; other site
1229205002868	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
1229205002869	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1229205002870	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1229205002871	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1229205002872	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
1229205002873	Walker A/P-loop; other site
1229205002874	ATP binding site [chemical binding]; other site
1229205002875	Q-loop/lid; other site
1229205002876	ABC transporter signature motif; other site
1229205002877	Walker B; other site
1229205002878	D-loop; other site
1229205002879	H-loop/switch region; other site
1229205002880	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
1229205002881	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
1229205002882	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
1229205002883	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
1229205002884	urea carboxylase; Region: urea_carbox; TIGR02712
1229205002885	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1229205002886	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1229205002887	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
1229205002888	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
1229205002889	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
1229205002890	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1229205002891	carboxyltransferase (CT) interaction site; other site
1229205002892	biotinylation site [posttranslational modification]; other site
1229205002893	allophanate hydrolase; Provisional; Region: PRK08186
1229205002894	Amidase; Region: Amidase; cl11426
1229205002895	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1229205002896	ligand binding site [chemical binding]; other site
1229205002897	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
1229205002898	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
1229205002899	trimer interface [polypeptide binding]; other site
1229205002900	YadA-like C-terminal region; Region: YadA; pfam03895
1229205002901	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
1229205002902	trimer interface [polypeptide binding]; other site
1229205002903	Haemagglutinin; Region: HIM; pfam05662
1229205002904	Response regulator receiver domain; Region: Response_reg; pfam00072
1229205002905	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205002906	active site
1229205002907	phosphorylation site [posttranslational modification]
1229205002908	intermolecular recognition site; other site
1229205002909	dimerization interface [polypeptide binding]; other site
1229205002910	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1229205002911	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205002912	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
1229205002913	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
1229205002914	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229205002915	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205002916	dimer interface [polypeptide binding]; other site
1229205002917	phosphorylation site [posttranslational modification]
1229205002918	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205002919	ATP binding site [chemical binding]; other site
1229205002920	Mg2+ binding site [ion binding]; other site
1229205002921	G-X-G motif; other site
1229205002922	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
1229205002923	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1229205002924	N-terminal plug; other site
1229205002925	ligand-binding site [chemical binding]; other site
1229205002926	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1229205002927	PAS domain; Region: PAS; smart00091
1229205002928	putative active site [active]
1229205002929	heme pocket [chemical binding]; other site
1229205002930	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1229205002931	PAS fold; Region: PAS_3; pfam08447
1229205002932	putative active site [active]
1229205002933	heme pocket [chemical binding]; other site
1229205002934	PAS domain S-box; Region: sensory_box; TIGR00229
1229205002935	PAS domain S-box; Region: sensory_box; TIGR00229
1229205002936	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1229205002937	putative active site [active]
1229205002938	heme pocket [chemical binding]; other site
1229205002939	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1229205002940	PAS domain; Region: PAS_9; pfam13426
1229205002941	putative active site [active]
1229205002942	heme pocket [chemical binding]; other site
1229205002943	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1229205002944	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1229205002945	metal binding site [ion binding]; metal-binding site
1229205002946	active site
1229205002947	I-site; other site
1229205002948	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
1229205002949	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1229205002950	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1229205002951	metal binding site [ion binding]; metal-binding site
1229205002952	active site
1229205002953	I-site; other site
1229205002954	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1229205002955	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229205002956	substrate binding pocket [chemical binding]; other site
1229205002957	membrane-bound complex binding site; other site
1229205002958	hinge residues; other site
1229205002959	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1229205002960	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1229205002961	putative dimer interface [polypeptide binding]; other site
1229205002962	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1229205002963	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1229205002964	metal binding site [ion binding]; metal-binding site
1229205002965	active site
1229205002966	I-site; other site
1229205002967	Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834
1229205002968	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
1229205002969	Cl binding site [ion binding]; other site
1229205002970	oligomer interface [polypeptide binding]; other site
1229205002971	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1229205002972	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1229205002973	dimer interface [polypeptide binding]; other site
1229205002974	putative CheW interface [polypeptide binding]; other site
1229205002975	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
1229205002976	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1229205002977	ligand binding site [chemical binding]; other site
1229205002978	Leucine rich repeat; Region: LRR_8; pfam13855
1229205002979	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1229205002980	Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714
1229205002981	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1229205002982	active site
1229205002983	ATP binding site [chemical binding]; other site
1229205002984	substrate binding site [chemical binding]; other site
1229205002985	activation loop (A-loop); other site
1229205002986	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
1229205002987	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1229205002988	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1229205002989	DNA binding site [nucleotide binding]
1229205002990	active site
1229205002991	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
1229205002992	Cache domain; Region: Cache_2; pfam08269
1229205002993	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1229205002994	dimer interface [polypeptide binding]; other site
1229205002995	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
1229205002996	putative CheW interface [polypeptide binding]; other site
1229205002997	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205002998	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229205002999	putative substrate translocation pore; other site
1229205003000	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205003001	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
1229205003002	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1229205003003	putative active site [active]
1229205003004	catalytic residue [active]
1229205003005	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
1229205003006	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
1229205003007	active site
1229205003008	tetramer interface [polypeptide binding]; other site
1229205003009	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205003010	D-galactonate transporter; Region: 2A0114; TIGR00893
1229205003011	putative substrate translocation pore; other site
1229205003012	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1229205003013	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205003014	DNA-binding site [nucleotide binding]; DNA binding site
1229205003015	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1229205003016	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
1229205003017	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
1229205003018	Citrate transporter; Region: CitMHS; pfam03600
1229205003019	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205003020	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205003021	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
1229205003022	putative dimerization interface [polypeptide binding]; other site
1229205003023	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1229205003024	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1229205003025	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1229205003026	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
1229205003027	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
1229205003028	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
1229205003029	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1229205003030	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
1229205003031	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1229205003032	putative active site [active]
1229205003033	metal binding site [ion binding]; metal-binding site
1229205003034	Phospholipid methyltransferase; Region: PEMT; cl17370
1229205003035	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1229205003036	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
1229205003037	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229205003038	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205003039	dimer interface [polypeptide binding]; other site
1229205003040	phosphorylation site [posttranslational modification]
1229205003041	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205003042	ATP binding site [chemical binding]; other site
1229205003043	Mg2+ binding site [ion binding]; other site
1229205003044	G-X-G motif; other site
1229205003045	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
1229205003046	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205003047	active site
1229205003048	phosphorylation site [posttranslational modification]
1229205003049	intermolecular recognition site; other site
1229205003050	dimerization interface [polypeptide binding]; other site
1229205003051	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229205003052	DNA binding site [nucleotide binding]
1229205003053	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1229205003054	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1229205003055	membrane-bound complex binding site; other site
1229205003056	hinge residues; other site
1229205003057	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1229205003058	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1229205003059	Walker A/P-loop; other site
1229205003060	ATP binding site [chemical binding]; other site
1229205003061	Q-loop/lid; other site
1229205003062	ABC transporter signature motif; other site
1229205003063	Walker B; other site
1229205003064	D-loop; other site
1229205003065	H-loop/switch region; other site
1229205003066	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1229205003067	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205003068	dimer interface [polypeptide binding]; other site
1229205003069	conserved gate region; other site
1229205003070	putative PBP binding loops; other site
1229205003071	ABC-ATPase subunit interface; other site
1229205003072	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229205003073	binding surface
1229205003074	TPR motif; other site
1229205003075	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1229205003076	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229205003077	binding surface
1229205003078	TPR motif; other site
1229205003079	TPR repeat; Region: TPR_11; pfam13414
1229205003080	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
1229205003081	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
1229205003082	Phosphoesterase family; Region: Phosphoesterase; pfam04185
1229205003083	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
1229205003084	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1229205003085	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
1229205003086	active site lid residues [active]
1229205003087	substrate binding pocket [chemical binding]; other site
1229205003088	catalytic residues [active]
1229205003089	substrate-Mg2+ binding site; other site
1229205003090	aspartate-rich region 1; other site
1229205003091	aspartate-rich region 2; other site
1229205003092	MarR family; Region: MarR_2; cl17246
1229205003093	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1229205003094	circadian clock protein KaiC; Reviewed; Region: PRK09302
1229205003095	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1229205003096	ATP binding site [chemical binding]; other site
1229205003097	Walker A motif; other site
1229205003098	Walker B motif; other site
1229205003099	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1229205003100	ATP binding site [chemical binding]; other site
1229205003101	Walker A motif; other site
1229205003102	Walker B motif; other site
1229205003103	Response regulator receiver domain; Region: Response_reg; pfam00072
1229205003104	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205003105	active site
1229205003106	phosphorylation site [posttranslational modification]
1229205003107	intermolecular recognition site; other site
1229205003108	dimerization interface [polypeptide binding]; other site
1229205003109	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1229205003110	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1229205003111	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205003112	The C-terminal substrate-domain of LysR-type transcriptional regulators for beta-lactamase genes, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_beta_lactamase; cd08484
1229205003113	putative dimerization interface [polypeptide binding]; other site
1229205003114	putative substrate binding pocket [chemical binding]; other site
1229205003115	Lecithin retinol acyltransferase; Region: LRAT; pfam04970
1229205003116	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1229205003117	active site
1229205003118	phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608
1229205003119	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205003120	Walker A motif; other site
1229205003121	ATP binding site [chemical binding]; other site
1229205003122	Walker B motif; other site
1229205003123	arginine finger; other site
1229205003124	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1229205003125	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1229205003126	ligand binding site [chemical binding]; other site
1229205003127	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1229205003128	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1229205003129	ligand binding site [chemical binding]; other site
1229205003130	flexible hinge region; other site
1229205003131	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
1229205003132	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
1229205003133	putative active site [active]
1229205003134	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1229205003135	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229205003136	Walker A/P-loop; other site
1229205003137	ATP binding site [chemical binding]; other site
1229205003138	Q-loop/lid; other site
1229205003139	ABC transporter signature motif; other site
1229205003140	Walker B; other site
1229205003141	D-loop; other site
1229205003142	H-loop/switch region; other site
1229205003143	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
1229205003144	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1229205003145	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1229205003146	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1229205003147	HlyD family secretion protein; Region: HlyD_3; pfam13437
1229205003148	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1229205003149	phosphopeptide binding site; other site
1229205003150	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1229205003151	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1229205003152	phosphopeptide binding site; other site
1229205003153	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1229205003154	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1229205003155	Domain of unknown function (DUF4399); Region: DUF4399; pfam14347
1229205003156	Domain of unknown function (DUF4399); Region: DUF4399; pfam14347
1229205003157	Caspase domain; Region: Peptidase_C14; pfam00656
1229205003158	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1229205003159	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1229205003160	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1229205003161	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1229205003162	active site
1229205003163	ATP binding site [chemical binding]; other site
1229205003164	substrate binding site [chemical binding]; other site
1229205003165	activation loop (A-loop); other site
1229205003166	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
1229205003167	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229205003168	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229205003169	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205003170	putative substrate translocation pore; other site
1229205003171	Protein of unknown function (DUF3309); Region: DUF3309; pfam11752
1229205003172	glucose-1-dehydrogenase; Provisional; Region: PRK08936
1229205003173	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
1229205003174	NAD binding site [chemical binding]; other site
1229205003175	homodimer interface [polypeptide binding]; other site
1229205003176	active site
1229205003177	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1229205003178	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1229205003179	putative DNA binding site [nucleotide binding]; other site
1229205003180	putative Zn2+ binding site [ion binding]; other site
1229205003181	AsnC family; Region: AsnC_trans_reg; pfam01037
1229205003182	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
1229205003183	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205003184	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
1229205003185	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1229205003186	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205003187	D-galactonate transporter; Region: 2A0114; TIGR00893
1229205003188	putative substrate translocation pore; other site
1229205003189	Protein of unknown function (DUF2783); Region: DUF2783; pfam10932
1229205003190	FAD-dependent oxidoreductase; Provisional; Region: PRK08132
1229205003191	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1229205003192	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1229205003193	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1229205003194	Bacterial transcriptional regulator; Region: IclR; pfam01614
1229205003195	Bacterial transcriptional regulator; Region: IclR; pfam01614
1229205003196	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
1229205003197	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1229205003198	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1229205003199	putative active site [active]
1229205003200	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1229205003201	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1229205003202	Walker A/P-loop; other site
1229205003203	ATP binding site [chemical binding]; other site
1229205003204	Q-loop/lid; other site
1229205003205	ABC transporter signature motif; other site
1229205003206	Walker B; other site
1229205003207	D-loop; other site
1229205003208	H-loop/switch region; other site
1229205003209	TOBE domain; Region: TOBE_2; pfam08402
1229205003210	short chain dehydrogenase; Provisional; Region: PRK07074
1229205003211	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205003212	NAD(P) binding site [chemical binding]; other site
1229205003213	active site
1229205003214	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1229205003215	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1229205003216	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1229205003217	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1229205003218	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205003219	dimer interface [polypeptide binding]; other site
1229205003220	putative PBP binding loops; other site
1229205003221	ABC-ATPase subunit interface; other site
1229205003222	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1229205003223	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205003224	dimer interface [polypeptide binding]; other site
1229205003225	conserved gate region; other site
1229205003226	putative PBP binding loops; other site
1229205003227	ABC-ATPase subunit interface; other site
1229205003228	Protein of unknown function (DUF1330); Region: DUF1330; pfam07045
1229205003229	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1229205003230	active site
1229205003231	tetramer interface; other site
1229205003232	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
1229205003233	Helix-turn-helix domain; Region: HTH_18; pfam12833
1229205003234	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205003235	D-galactonate transporter; Region: 2A0114; TIGR00893
1229205003236	putative substrate translocation pore; other site
1229205003237	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205003238	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205003239	LysR substrate binding domain; Region: LysR_substrate; pfam03466
1229205003240	dimerization interface [polypeptide binding]; other site
1229205003241	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1229205003242	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1229205003243	SAM (Sterile alpha motif ); Region: SAM_superfamily; cl15755
1229205003244	enoyl-CoA hydratase; Provisional; Region: PRK06144
1229205003245	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1229205003246	substrate binding site [chemical binding]; other site
1229205003247	oxyanion hole (OAH) forming residues; other site
1229205003248	trimer interface [polypeptide binding]; other site
1229205003249	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
1229205003250	Interdomain contacts; other site
1229205003251	Cytokine receptor motif; other site
1229205003252	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1229205003253	active site
1229205003254	metal binding site [ion binding]; metal-binding site
1229205003255	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1229205003256	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1229205003257	metal binding site [ion binding]; metal-binding site
1229205003258	active site
1229205003259	I-site; other site
1229205003260	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1229205003261	Protein of unknown function (DUF1697); Region: DUF1697; pfam08002
1229205003262	Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948
1229205003263	Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988
1229205003264	PQQ-like domain; Region: PQQ_2; pfam13360
1229205003265	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1229205003266	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1229205003267	conserved cys residue [active]
1229205003268	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205003269	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1229205003270	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205003271	NAD(P) binding site [chemical binding]; other site
1229205003272	active site
1229205003273	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205003274	metabolite-proton symporter; Region: 2A0106; TIGR00883
1229205003275	putative substrate translocation pore; other site
1229205003276	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
1229205003277	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229205003278	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229205003279	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1229205003280	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1229205003281	HlyD family secretion protein; Region: HlyD_3; pfam13437
1229205003282	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1229205003283	short chain dehydrogenase; Provisional; Region: PRK06179
1229205003284	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1229205003285	NADP binding site [chemical binding]; other site
1229205003286	active site
1229205003287	steroid binding site; other site
1229205003288	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
1229205003289	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812
1229205003290	dimer interface [polypeptide binding]; other site
1229205003291	active site
1229205003292	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1229205003293	substrate binding site [chemical binding]; other site
1229205003294	catalytic residue [active]
1229205003295	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
1229205003296	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1229205003297	NAD binding site [chemical binding]; other site
1229205003298	catalytic residues [active]
1229205003299	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205003300	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205003301	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205003302	dimerization interface [polypeptide binding]; other site
1229205003303	Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970
1229205003304	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1229205003305	dihydroxy-acid dehydratase; Provisional; Region: PRK13017
1229205003306	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1229205003307	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1229205003308	DNA binding site [nucleotide binding]
1229205003309	domain linker motif; other site
1229205003310	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
1229205003311	putative dimerization interface [polypeptide binding]; other site
1229205003312	putative ligand binding site [chemical binding]; other site
1229205003313	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205003314	D-galactonate transporter; Region: 2A0114; TIGR00893
1229205003315	putative substrate translocation pore; other site
1229205003316	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205003317	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205003318	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1229205003319	putative effector binding pocket; other site
1229205003320	dimerization interface [polypeptide binding]; other site
1229205003321	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1229205003322	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1229205003323	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1229205003324	dimerization interface [polypeptide binding]; other site
1229205003325	ligand binding site [chemical binding]; other site
1229205003326	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1229205003327	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1229205003328	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1229205003329	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1229205003330	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1229205003331	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205003332	DNA-binding site [nucleotide binding]; DNA binding site
1229205003333	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229205003334	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205003335	homodimer interface [polypeptide binding]; other site
1229205003336	catalytic residue [active]
1229205003337	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
1229205003338	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1229205003339	active site
1229205003340	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
1229205003341	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205003342	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205003343	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
1229205003344	putative dimerization interface [polypeptide binding]; other site
1229205003345	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205003346	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205003347	eyelet of channel; other site
1229205003348	trimer interface [polypeptide binding]; other site
1229205003349	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205003350	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229205003351	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205003352	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1229205003353	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1229205003354	inhibitor site; inhibition site
1229205003355	active site
1229205003356	dimer interface [polypeptide binding]; other site
1229205003357	catalytic residue [active]
1229205003358	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1229205003359	active site
1229205003360	Repair protein; Region: Repair_PSII; pfam04536
1229205003361	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
1229205003362	Repair protein; Region: Repair_PSII; pfam04536
1229205003363	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
1229205003364	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
1229205003365	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
1229205003366	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1229205003367	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1229205003368	salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255
1229205003369	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1229205003370	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
1229205003371	active site
1229205003372	FMN binding site [chemical binding]; other site
1229205003373	substrate binding site [chemical binding]; other site
1229205003374	homotetramer interface [polypeptide binding]; other site
1229205003375	catalytic residue [active]
1229205003376	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1229205003377	classical (c) SDRs; Region: SDR_c; cd05233
1229205003378	NAD(P) binding site [chemical binding]; other site
1229205003379	active site
1229205003380	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1229205003381	MarR family; Region: MarR; pfam01047
1229205003382	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1229205003383	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1229205003384	substrate binding site [chemical binding]; other site
1229205003385	oxyanion hole (OAH) forming residues; other site
1229205003386	trimer interface [polypeptide binding]; other site
1229205003387	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1229205003388	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1229205003389	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1229205003390	active site
1229205003391	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1229205003392	active site
1229205003393	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1229205003394	homotrimer interaction site [polypeptide binding]; other site
1229205003395	putative active site [active]
1229205003396	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1229205003397	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
1229205003398	acyl-activating enzyme (AAE) consensus motif; other site
1229205003399	AMP binding site [chemical binding]; other site
1229205003400	active site
1229205003401	CoA binding site [chemical binding]; other site
1229205003402	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1229205003403	SnoaL-like domain; Region: SnoaL_2; pfam12680
1229205003404	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205003405	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229205003406	putative substrate translocation pore; other site
1229205003407	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1229205003408	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229205003409	binding surface
1229205003410	TPR motif; other site
1229205003411	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229205003412	binding surface
1229205003413	TPR motif; other site
1229205003414	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1229205003415	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
1229205003416	putative active site [active]
1229205003417	putative NTP binding site [chemical binding]; other site
1229205003418	putative nucleic acid binding site [nucleotide binding]; other site
1229205003419	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
1229205003420	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1229205003421	putative active site [active]
1229205003422	putative NTP binding site [chemical binding]; other site
1229205003423	putative nucleic acid binding site [nucleotide binding]; other site
1229205003424	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1229205003425	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1229205003426	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205003427	DNA-binding site [nucleotide binding]; DNA binding site
1229205003428	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229205003429	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205003430	homodimer interface [polypeptide binding]; other site
1229205003431	catalytic residue [active]
1229205003432	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1229205003433	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1229205003434	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1229205003435	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1229205003436	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
1229205003437	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205003438	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1229205003439	dimerization interface [polypeptide binding]; other site
1229205003440	substrate binding pocket [chemical binding]; other site
1229205003441	Predicted permeases [General function prediction only]; Region: COG0679
1229205003442	Domain of unknown function (DUF4337); Region: DUF4337; pfam14235
1229205003443	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1229205003444	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
1229205003445	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1229205003446	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
1229205003447	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1229205003448	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
1229205003449	YCII-related domain; Region: YCII; cl00999
1229205003450	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
1229205003451	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
1229205003452	Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883
1229205003453	High potential iron-sulfur protein; Region: HIPIP; pfam01355
1229205003454	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
1229205003455	putative FMN binding site [chemical binding]; other site
1229205003456	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1229205003457	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1229205003458	active site
1229205003459	catalytic tetrad [active]
1229205003460	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1229205003461	substrate binding site [chemical binding]; other site
1229205003462	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1229205003463	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1229205003464	nucleotide binding site [chemical binding]; other site
1229205003465	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
1229205003466	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1229205003467	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1229205003468	Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200
1229205003469	glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561
1229205003470	Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439
1229205003471	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
1229205003472	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
1229205003473	Phosphoesterase family; Region: Phosphoesterase; pfam04185
1229205003474	Domain of unknown function (DUF756); Region: DUF756; pfam05506
1229205003475	Domain of unknown function (DUF756); Region: DUF756; pfam05506
1229205003476	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
1229205003477	active site
1229205003478	Zn binding site [ion binding]; other site
1229205003479	ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010
1229205003480	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229205003481	substrate binding pocket [chemical binding]; other site
1229205003482	membrane-bound complex binding site; other site
1229205003483	hinge residues; other site
1229205003484	putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791
1229205003485	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205003486	LysR substrate binding domain; Region: LysR_substrate; pfam03466
1229205003487	dimerization interface [polypeptide binding]; other site
1229205003488	Rubredoxin; Region: Rubredoxin; pfam00301
1229205003489	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
1229205003490	iron binding site [ion binding]; other site
1229205003491	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1229205003492	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1229205003493	[2Fe-2S] cluster binding site [ion binding]; other site
1229205003494	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1229205003495	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1229205003496	DXD motif; other site
1229205003497	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1229205003498	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
1229205003499	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
1229205003500	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1229205003501	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1229205003502	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229205003503	Coenzyme A binding pocket [chemical binding]; other site
1229205003504	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
1229205003505	RHS Repeat; Region: RHS_repeat; pfam05593
1229205003506	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
1229205003507	RHS Repeat; Region: RHS_repeat; cl11982
1229205003508	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
1229205003509	RHS Repeat; Region: RHS_repeat; cl11982
1229205003510	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
1229205003511	benzoate transport; Region: 2A0115; TIGR00895
1229205003512	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205003513	putative substrate translocation pore; other site
1229205003514	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205003515	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
1229205003516	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1229205003517	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1229205003518	active site
1229205003519	metal binding site [ion binding]; metal-binding site
1229205003520	C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360
1229205003521	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1229205003522	putative active site [active]
1229205003523	putative metal binding site [ion binding]; other site
1229205003524	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1229205003525	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
1229205003526	NAD(P) binding site [chemical binding]; other site
1229205003527	catalytic residues [active]
1229205003528	L-aspartate dehydrogenase; Provisional; Region: PRK13303
1229205003529	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1229205003530	Domain of unknown function DUF108; Region: DUF108; pfam01958
1229205003531	hypothetical protein; Provisional; Region: PRK07064
1229205003532	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1229205003533	PYR/PP interface [polypeptide binding]; other site
1229205003534	dimer interface [polypeptide binding]; other site
1229205003535	TPP binding site [chemical binding]; other site
1229205003536	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1229205003537	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
1229205003538	TPP-binding site [chemical binding]; other site
1229205003539	short chain dehydrogenase; Provisional; Region: PRK07062
1229205003540	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
1229205003541	putative NAD(P) binding site [chemical binding]; other site
1229205003542	putative active site [active]
1229205003543	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1229205003544	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1229205003545	Bacterial transcriptional regulator; Region: IclR; pfam01614
1229205003546	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1229205003547	Serine hydrolase; Region: Ser_hydrolase; cl17834
1229205003548	Cupin domain; Region: Cupin_2; pfam07883
1229205003549	short chain dehydrogenase; Provisional; Region: PRK12939
1229205003550	classical (c) SDRs; Region: SDR_c; cd05233
1229205003551	NAD(P) binding site [chemical binding]; other site
1229205003552	active site
1229205003553	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1229205003554	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1229205003555	[2Fe-2S] cluster binding site [ion binding]; other site
1229205003556	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1229205003557	hydrophobic ligand binding site; other site
1229205003558	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
1229205003559	[2Fe-2S] cluster binding site [ion binding]; other site
1229205003560	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205003561	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205003562	trimer interface [polypeptide binding]; other site
1229205003563	eyelet of channel; other site
1229205003564	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1229205003565	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1229205003566	Bacterial transcriptional regulator; Region: IclR; pfam01614
1229205003567	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
1229205003568	acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397
1229205003569	Protein of unknown function (DUF3564); Region: DUF3564; pfam12087
1229205003570	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; pfam01223
1229205003571	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
1229205003572	active site
1229205003573	substrate binding site [chemical binding]; other site
1229205003574	Mg2+ binding site [ion binding]; other site
1229205003575	bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469
1229205003576	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1229205003577	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1229205003578	ligand binding site [chemical binding]; other site
1229205003579	flexible hinge region; other site
1229205003580	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
1229205003581	putative switch regulator; other site
1229205003582	non-specific DNA interactions [nucleotide binding]; other site
1229205003583	DNA binding site [nucleotide binding]
1229205003584	sequence specific DNA binding site [nucleotide binding]; other site
1229205003585	putative cAMP binding site [chemical binding]; other site
1229205003586	Predicted membrane protein [Function unknown]; Region: COG4539
1229205003587	Predicted permeases [General function prediction only]; Region: RarD; COG2962
1229205003588	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
1229205003589	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
1229205003590	acylphosphatase; Provisional; Region: PRK14424
1229205003591	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
1229205003592	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
1229205003593	putative NADP binding site [chemical binding]; other site
1229205003594	putative substrate binding site [chemical binding]; other site
1229205003595	active site
1229205003596	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
1229205003597	active site
1229205003598	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
1229205003599	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
1229205003600	LytB protein; Region: LYTB; pfam02401
1229205003601	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
1229205003602	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1229205003603	FeS/SAM binding site; other site
1229205003604	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
1229205003605	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
1229205003606	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
1229205003607	VacJ like lipoprotein; Region: VacJ; cl01073
1229205003608	hypothetical protein; Provisional; Region: PRK07077
1229205003609	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
1229205003610	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
1229205003611	Active site cavity [active]
1229205003612	catalytic acid [active]
1229205003613	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
1229205003614	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
1229205003615	active site lid residues [active]
1229205003616	substrate binding pocket [chemical binding]; other site
1229205003617	catalytic residues [active]
1229205003618	substrate-Mg2+ binding site; other site
1229205003619	aspartate-rich region 1; other site
1229205003620	aspartate-rich region 2; other site
1229205003621	PAS fold; Region: PAS; pfam00989
1229205003622	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1229205003623	putative active site [active]
1229205003624	heme pocket [chemical binding]; other site
1229205003625	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1229205003626	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1229205003627	metal binding site [ion binding]; metal-binding site
1229205003628	active site
1229205003629	I-site; other site
1229205003630	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
1229205003631	CheC-like family; Region: CheC; pfam04509
1229205003632	Response regulator receiver domain; Region: Response_reg; pfam00072
1229205003633	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205003634	active site
1229205003635	phosphorylation site [posttranslational modification]
1229205003636	intermolecular recognition site; other site
1229205003637	dimerization interface [polypeptide binding]; other site
1229205003638	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229205003639	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1229205003640	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205003641	ATP binding site [chemical binding]; other site
1229205003642	Mg2+ binding site [ion binding]; other site
1229205003643	G-X-G motif; other site
1229205003644	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1229205003645	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205003646	active site
1229205003647	phosphorylation site [posttranslational modification]
1229205003648	intermolecular recognition site; other site
1229205003649	dimerization interface [polypeptide binding]; other site
1229205003650	Predicted flavoprotein [General function prediction only]; Region: COG0431
1229205003651	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1229205003652	RNA polymerase sigma factor; Provisional; Region: PRK12545
1229205003653	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1229205003654	DNA binding residues [nucleotide binding]
1229205003655	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813
1229205003656	Protein of unknown function (DUF1272); Region: DUF1272; pfam06906
1229205003657	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
1229205003658	catalytic residues [active]
1229205003659	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1229205003660	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1229205003661	Magnesium ion binding site [ion binding]; other site
1229205003662	ParB-like nuclease domain; Region: ParB; smart00470
1229205003663	Initiator Replication protein; Region: Rep_3; pfam01051
1229205003664	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1229205003665	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1229205003666	active site
1229205003667	catalytic residues [active]
1229205003668	Int/Topo IB signature motif; other site
1229205003669	DNA binding site [nucleotide binding]
1229205003670	Protein of unknown function (DUF2471); Region: DUF2471; pfam10616
1229205003671	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1229205003672	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229205003673	non-specific DNA binding site [nucleotide binding]; other site
1229205003674	salt bridge; other site
1229205003675	sequence-specific DNA binding site [nucleotide binding]; other site
1229205003676	Cupin domain; Region: Cupin_2; pfam07883
1229205003677	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1229205003678	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1229205003679	substrate-cofactor binding pocket; other site
1229205003680	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205003681	catalytic residue [active]
1229205003682	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
1229205003683	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1229205003684	NAD(P) binding site [chemical binding]; other site
1229205003685	YceI-like domain; Region: YceI; smart00867
1229205003686	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229205003687	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229205003688	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
1229205003689	SnoaL-like domain; Region: SnoaL_2; pfam12680
1229205003690	CHASE3 domain; Region: CHASE3; pfam05227
1229205003691	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1229205003692	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1229205003693	metal binding site [ion binding]; metal-binding site
1229205003694	active site
1229205003695	I-site; other site
1229205003696	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1229205003697	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1229205003698	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1229205003699	dimerization interface [polypeptide binding]; other site
1229205003700	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1229205003701	putative binding surface; other site
1229205003702	active site
1229205003703	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205003704	ATP binding site [chemical binding]; other site
1229205003705	Mg2+ binding site [ion binding]; other site
1229205003706	G-X-G motif; other site
1229205003707	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
1229205003708	Response regulator receiver domain; Region: Response_reg; pfam00072
1229205003709	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205003710	active site
1229205003711	phosphorylation site [posttranslational modification]
1229205003712	intermolecular recognition site; other site
1229205003713	dimerization interface [polypeptide binding]; other site
1229205003714	short chain dehydrogenase; Provisional; Region: PRK07023
1229205003715	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205003716	NAD(P) binding site [chemical binding]; other site
1229205003717	active site
1229205003718	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1229205003719	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1229205003720	conserved cys residue [active]
1229205003721	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205003722	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205003723	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205003724	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
1229205003725	putative dimerization interface [polypeptide binding]; other site
1229205003726	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1229205003727	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1229205003728	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
1229205003729	active site
1229205003730	catalytic residues [active]
1229205003731	metal binding site [ion binding]; metal-binding site
1229205003732	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205003733	D-galactonate transporter; Region: 2A0114; TIGR00893
1229205003734	putative substrate translocation pore; other site
1229205003735	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205003736	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1229205003737	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
1229205003738	RHS Repeat; Region: RHS_repeat; pfam05593
1229205003739	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1229205003740	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205003741	DNA-binding site [nucleotide binding]; DNA binding site
1229205003742	FCD domain; Region: FCD; pfam07729
1229205003743	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
1229205003744	homodimer interface [polypeptide binding]; other site
1229205003745	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205003746	catalytic residue [active]
1229205003747	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205003748	D-galactonate transporter; Region: 2A0114; TIGR00893
1229205003749	putative substrate translocation pore; other site
1229205003750	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
1229205003751	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1229205003752	FAD binding domain; Region: FAD_binding_4; pfam01565
1229205003753	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1229205003754	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1229205003755	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205003756	EamA-like transporter family; Region: EamA; pfam00892
1229205003757	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1229205003758	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1229205003759	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
1229205003760	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
1229205003761	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1229205003762	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1229205003763	ligand binding site [chemical binding]; other site
1229205003764	flexible hinge region; other site
1229205003765	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1229205003766	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1229205003767	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1229205003768	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1229205003769	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1229205003770	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
1229205003771	active site residue [active]
1229205003772	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318
1229205003773	DinB superfamily; Region: DinB_2; pfam12867
1229205003774	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1229205003775	PAS domain; Region: PAS_9; pfam13426
1229205003776	putative active site [active]
1229205003777	heme pocket [chemical binding]; other site
1229205003778	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1229205003779	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1229205003780	dimer interface [polypeptide binding]; other site
1229205003781	putative CheW interface [polypeptide binding]; other site
1229205003782	hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841
1229205003783	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205003784	dimer interface [polypeptide binding]; other site
1229205003785	phosphorylation site [posttranslational modification]
1229205003786	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205003787	ATP binding site [chemical binding]; other site
1229205003788	Mg2+ binding site [ion binding]; other site
1229205003789	G-X-G motif; other site
1229205003790	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205003791	active site
1229205003792	phosphorylation site [posttranslational modification]
1229205003793	intermolecular recognition site; other site
1229205003794	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1229205003795	homotrimer interaction site [polypeptide binding]; other site
1229205003796	putative active site [active]
1229205003797	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
1229205003798	PAS fold; Region: PAS_4; pfam08448
1229205003799	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
1229205003800	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205003801	Walker A motif; other site
1229205003802	ATP binding site [chemical binding]; other site
1229205003803	Walker B motif; other site
1229205003804	arginine finger; other site
1229205003805	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1229205003806	Beta-lactamase; Region: Beta-lactamase; pfam00144
1229205003807	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1229205003808	H-NS histone family; Region: Histone_HNS; pfam00816
1229205003809	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
1229205003810	Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714
1229205003811	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1229205003812	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1229205003813	active site
1229205003814	catalytic tetrad [active]
1229205003815	succinic semialdehyde dehydrogenase; Region: PLN02278
1229205003816	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1229205003817	tetramerization interface [polypeptide binding]; other site
1229205003818	NAD(P) binding site [chemical binding]; other site
1229205003819	catalytic residues [active]
1229205003820	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205003821	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
1229205003822	putative substrate translocation pore; other site
1229205003823	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
1229205003824	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
1229205003825	G1 box; other site
1229205003826	putative GEF interaction site [polypeptide binding]; other site
1229205003827	GTP/Mg2+ binding site [chemical binding]; other site
1229205003828	Switch I region; other site
1229205003829	G2 box; other site
1229205003830	G3 box; other site
1229205003831	Switch II region; other site
1229205003832	G4 box; other site
1229205003833	G5 box; other site
1229205003834	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
1229205003835	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1229205003836	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205003837	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205003838	dimerization interface [polypeptide binding]; other site
1229205003839	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
1229205003840	CoA binding domain; Region: CoA_binding_2; pfam13380
1229205003841	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
1229205003842	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1229205003843	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1229205003844	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
1229205003845	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
1229205003846	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
1229205003847	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
1229205003848	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
1229205003849	active site
1229205003850	active site
1229205003851	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1229205003852	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1229205003853	Bacterial transcriptional regulator; Region: IclR; pfam01614
1229205003854	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
1229205003855	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
1229205003856	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1229205003857	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1229205003858	active site
1229205003859	catalytic tetrad [active]
1229205003860	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
1229205003861	Amidohydrolase; Region: Amidohydro_2; pfam04909
1229205003862	active site
1229205003863	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
1229205003864	human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368
1229205003865	NAD binding site [chemical binding]; other site
1229205003866	homotetramer interface [polypeptide binding]; other site
1229205003867	homodimer interface [polypeptide binding]; other site
1229205003868	active site
1229205003869	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1229205003870	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1229205003871	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1229205003872	CoenzymeA binding site [chemical binding]; other site
1229205003873	subunit interaction site [polypeptide binding]; other site
1229205003874	PHB binding site; other site
1229205003875	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
1229205003876	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
1229205003877	dimer interface [polypeptide binding]; other site
1229205003878	ligand binding site [chemical binding]; other site
1229205003879	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1229205003880	dimerization interface [polypeptide binding]; other site
1229205003881	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1229205003882	dimer interface [polypeptide binding]; other site
1229205003883	putative CheW interface [polypeptide binding]; other site
1229205003884	dimerization interface [polypeptide binding]; other site
1229205003885	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
1229205003886	putative active cleft [active]
1229205003887	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
1229205003888	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1229205003889	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1229205003890	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1229205003891	Cache domain; Region: Cache_1; pfam02743
1229205003892	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
1229205003893	dimerization interface [polypeptide binding]; other site
1229205003894	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1229205003895	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1229205003896	dimer interface [polypeptide binding]; other site
1229205003897	putative CheW interface [polypeptide binding]; other site
1229205003898	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1229205003899	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1229205003900	metal-binding site [ion binding]
1229205003901	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1229205003902	Uncharacterized conserved protein [Function unknown]; Region: COG5361
1229205003903	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
1229205003904	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
1229205003905	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
1229205003906	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
1229205003907	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
1229205003908	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
1229205003909	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1229205003910	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205003911	DNA-binding site [nucleotide binding]; DNA binding site
1229205003912	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229205003913	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205003914	homodimer interface [polypeptide binding]; other site
1229205003915	catalytic residue [active]
1229205003916	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1229205003917	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229205003918	Walker A/P-loop; other site
1229205003919	ATP binding site [chemical binding]; other site
1229205003920	Q-loop/lid; other site
1229205003921	ABC transporter signature motif; other site
1229205003922	Walker B; other site
1229205003923	D-loop; other site
1229205003924	H-loop/switch region; other site
1229205003925	TOBE domain; Region: TOBE_2; pfam08402
1229205003926	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1229205003927	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1229205003928	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205003929	dimer interface [polypeptide binding]; other site
1229205003930	conserved gate region; other site
1229205003931	putative PBP binding loops; other site
1229205003932	ABC-ATPase subunit interface; other site
1229205003933	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1229205003934	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205003935	dimer interface [polypeptide binding]; other site
1229205003936	conserved gate region; other site
1229205003937	putative PBP binding loops; other site
1229205003938	ABC-ATPase subunit interface; other site
1229205003939	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1229205003940	ligand binding site [chemical binding]; other site
1229205003941	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1229205003942	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205003943	active site
1229205003944	phosphorylation site [posttranslational modification]
1229205003945	intermolecular recognition site; other site
1229205003946	dimerization interface [polypeptide binding]; other site
1229205003947	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1229205003948	DNA binding residues [nucleotide binding]
1229205003949	dimerization interface [polypeptide binding]; other site
1229205003950	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
1229205003951	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1229205003952	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1229205003953	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1229205003954	catalytic residue [active]
1229205003955	TadE-like protein; Region: TadE; pfam07811
1229205003956	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
1229205003957	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
1229205003958	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1229205003959	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
1229205003960	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1229205003961	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1229205003962	phosphopeptide binding site; other site
1229205003963	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
1229205003964	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1229205003965	ATP binding site [chemical binding]; other site
1229205003966	Walker A motif; other site
1229205003967	hexamer interface [polypeptide binding]; other site
1229205003968	Walker B motif; other site
1229205003969	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1229205003970	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
1229205003971	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
1229205003972	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
1229205003973	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
1229205003974	trimer interface [polypeptide binding]; other site
1229205003975	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
1229205003976	trimer interface [polypeptide binding]; other site
1229205003977	YadA-like C-terminal region; Region: YadA; pfam03895
1229205003978	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1229205003979	ligand binding site [chemical binding]; other site
1229205003980	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1229205003981	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205003982	active site
1229205003983	phosphorylation site [posttranslational modification]
1229205003984	intermolecular recognition site; other site
1229205003985	dimerization interface [polypeptide binding]; other site
1229205003986	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1229205003987	DNA binding residues [nucleotide binding]
1229205003988	dimerization interface [polypeptide binding]; other site
1229205003989	aconitate hydratase; Provisional; Region: acnA; PRK12881
1229205003990	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
1229205003991	substrate binding site [chemical binding]; other site
1229205003992	ligand binding site [chemical binding]; other site
1229205003993	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
1229205003994	substrate binding site [chemical binding]; other site
1229205003995	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
1229205003996	2-methylcitrate dehydratase; Region: prpD; TIGR02330
1229205003997	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1229205003998	coenzyme A binding site [chemical binding]; other site
1229205003999	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
1229205004000	citrylCoA binding site [chemical binding]; other site
1229205004001	oxalacetate binding site [chemical binding]; other site
1229205004002	catalytic triad [active]
1229205004003	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
1229205004004	malate dehydrogenase; Provisional; Region: PRK05442
1229205004005	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
1229205004006	NAD(P) binding site [chemical binding]; other site
1229205004007	dimer interface [polypeptide binding]; other site
1229205004008	malate binding site [chemical binding]; other site
1229205004009	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1229205004010	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205004011	DNA-binding site [nucleotide binding]; DNA binding site
1229205004012	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1229205004013	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
1229205004014	proximal quinone binding site [chemical binding]; other site
1229205004015	SdhD (CybS) interface [polypeptide binding]; other site
1229205004016	proximal heme binding site [chemical binding]; other site
1229205004017	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
1229205004018	SdhC subunit interface [polypeptide binding]; other site
1229205004019	proximal heme binding site [chemical binding]; other site
1229205004020	cardiolipin binding site; other site
1229205004021	Iron-sulfur protein interface; other site
1229205004022	proximal quinone binding site [chemical binding]; other site
1229205004023	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057
1229205004024	L-aspartate oxidase; Provisional; Region: PRK06175
1229205004025	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1229205004026	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1229205004027	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
1229205004028	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
1229205004029	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1229205004030	dimer interface [polypeptide binding]; other site
1229205004031	active site
1229205004032	citrylCoA binding site [chemical binding]; other site
1229205004033	NADH binding [chemical binding]; other site
1229205004034	cationic pore residues; other site
1229205004035	oxalacetate/citrate binding site [chemical binding]; other site
1229205004036	coenzyme A binding site [chemical binding]; other site
1229205004037	catalytic triad [active]
1229205004038	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1229205004039	Helix-turn-helix domain; Region: HTH_18; pfam12833
1229205004040	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205004041	Protein of unknown function (DUF1479); Region: DUF1479; pfam07350
1229205004042	Predicted membrane protein [Function unknown]; Region: COG2261
1229205004043	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1229205004044	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1229205004045	substrate binding site [chemical binding]; other site
1229205004046	ligand binding site [chemical binding]; other site
1229205004047	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1229205004048	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1229205004049	substrate binding site [chemical binding]; other site
1229205004050	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
1229205004051	tartrate dehydrogenase; Region: TTC; TIGR02089
1229205004052	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
1229205004053	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1229205004054	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
1229205004055	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1229205004056	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1229205004057	dimerization interface 3.5A [polypeptide binding]; other site
1229205004058	active site
1229205004059	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1229205004060	active site
1229205004061	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1229205004062	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1229205004063	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205004064	catalytic residue [active]
1229205004065	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
1229205004066	DNA methylase; Region: N6_N4_Mtase; pfam01555
1229205004067	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
1229205004068	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1229205004069	substrate binding site [chemical binding]; other site
1229205004070	active site
1229205004071	catalytic residues [active]
1229205004072	heterodimer interface [polypeptide binding]; other site
1229205004073	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
1229205004074	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
1229205004075	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1229205004076	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1229205004077	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1229205004078	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1229205004079	Sporulation related domain; Region: SPOR; pfam05036
1229205004080	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
1229205004081	Colicin V production protein; Region: Colicin_V; pfam02674
1229205004082	amidophosphoribosyltransferase; Provisional; Region: PRK09246
1229205004083	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1229205004084	active site
1229205004085	tetramer interface [polypeptide binding]; other site
1229205004086	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1229205004087	active site
1229205004088	Cupin domain; Region: Cupin_2; cl17218
1229205004089	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205004090	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1229205004091	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205004092	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
1229205004093	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1229205004094	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229205004095	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205004096	dimer interface [polypeptide binding]; other site
1229205004097	phosphorylation site [posttranslational modification]
1229205004098	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1229205004099	Domain of unknown function DUF21; Region: DUF21; pfam01595
1229205004100	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1229205004101	Transporter associated domain; Region: CorC_HlyC; smart01091
1229205004102	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
1229205004103	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
1229205004104	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
1229205004105	active site
1229205004106	catalytic site [active]
1229205004107	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
1229205004108	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
1229205004109	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
1229205004110	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
1229205004111	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
1229205004112	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
1229205004113	catalytic site [active]
1229205004114	active site
1229205004115	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1229205004116	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
1229205004117	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
1229205004118	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
1229205004119	active site
1229205004120	catalytic site [active]
1229205004121	glycogen branching enzyme; Provisional; Region: PRK05402
1229205004122	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
1229205004123	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
1229205004124	active site
1229205004125	catalytic site [active]
1229205004126	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
1229205004127	trehalose synthase; Region: treS_nterm; TIGR02456
1229205004128	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
1229205004129	active site
1229205004130	catalytic site [active]
1229205004131	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
1229205004132	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
1229205004133	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
1229205004134	active site
1229205004135	catalytic site [active]
1229205004136	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
1229205004137	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
1229205004138	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1229205004139	active site
1229205004140	homodimer interface [polypeptide binding]; other site
1229205004141	catalytic site [active]
1229205004142	acceptor binding site [chemical binding]; other site
1229205004143	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
1229205004144	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1229205004145	active site
1229205004146	metal binding site [ion binding]; metal-binding site
1229205004147	RES domain; Region: RES; smart00953
1229205004148	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
1229205004149	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205004150	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205004151	dimerization interface [polypeptide binding]; other site
1229205004152	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1229205004153	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1229205004154	dimer interface [polypeptide binding]; other site
1229205004155	hexamer interface [polypeptide binding]; other site
1229205004156	active site 2 [active]
1229205004157	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
1229205004158	TOBE domain; Region: TOBE; cl01440
1229205004159	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
1229205004160	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229205004161	thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277
1229205004162	Walker A/P-loop; other site
1229205004163	ATP binding site [chemical binding]; other site
1229205004164	Q-loop/lid; other site
1229205004165	ABC transporter signature motif; other site
1229205004166	Walker B; other site
1229205004167	D-loop; other site
1229205004168	H-loop/switch region; other site
1229205004169	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205004170	dimer interface [polypeptide binding]; other site
1229205004171	conserved gate region; other site
1229205004172	putative PBP binding loops; other site
1229205004173	ABC-ATPase subunit interface; other site
1229205004174	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
1229205004175	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1229205004176	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
1229205004177	active site
1229205004178	Esterase PHB depolymerase; Region: Esterase_phd; pfam10503
1229205004179	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
1229205004180	DNA photolyase; Region: DNA_photolyase; pfam00875
1229205004181	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
1229205004182	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
1229205004183	putative active site [active]
1229205004184	putative substrate binding site [chemical binding]; other site
1229205004185	ATP binding site [chemical binding]; other site
1229205004186	AMP nucleosidase; Provisional; Region: PRK08292
1229205004187	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
1229205004188	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
1229205004189	Chromate transporter; Region: Chromate_transp; pfam02417
1229205004190	Chromate transporter; Region: Chromate_transp; pfam02417
1229205004191	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1229205004192	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205004193	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1229205004194	dimerization interface [polypeptide binding]; other site
1229205004195	substrate binding pocket [chemical binding]; other site
1229205004196	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
1229205004197	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1229205004198	DNA polymerase I; Provisional; Region: PRK05755
1229205004199	active site
1229205004200	putative 5' ssDNA interaction site; other site
1229205004201	metal binding site 3; metal-binding site
1229205004202	metal binding site 1 [ion binding]; metal-binding site
1229205004203	metal binding site 2 [ion binding]; metal-binding site
1229205004204	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1229205004205	putative DNA binding site [nucleotide binding]; other site
1229205004206	putative metal binding site [ion binding]; other site
1229205004207	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
1229205004208	active site
1229205004209	catalytic site [active]
1229205004210	substrate binding site [chemical binding]; other site
1229205004211	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1229205004212	active site
1229205004213	DNA binding site [nucleotide binding]
1229205004214	catalytic site [active]
1229205004215	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1229205004216	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1229205004217	Dienelactone hydrolase family; Region: DLH; pfam01738
1229205004218	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1229205004219	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1229205004220	active site residue [active]
1229205004221	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1229205004222	active site residue [active]
1229205004223	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1229205004224	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1229205004225	[2Fe-2S] cluster binding site [ion binding]; other site
1229205004226	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
1229205004227	alpha subunit interface [polypeptide binding]; other site
1229205004228	active site
1229205004229	substrate binding site [chemical binding]; other site
1229205004230	Fe binding site [ion binding]; other site
1229205004231	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
1229205004232	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1229205004233	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1229205004234	substrate binding pocket [chemical binding]; other site
1229205004235	chain length determination region; other site
1229205004236	substrate-Mg2+ binding site; other site
1229205004237	catalytic residues [active]
1229205004238	aspartate-rich region 1; other site
1229205004239	active site lid residues [active]
1229205004240	aspartate-rich region 2; other site
1229205004241	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
1229205004242	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1229205004243	TPP-binding site; other site
1229205004244	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1229205004245	PYR/PP interface [polypeptide binding]; other site
1229205004246	dimer interface [polypeptide binding]; other site
1229205004247	TPP binding site [chemical binding]; other site
1229205004248	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1229205004249	putative GTP cyclohydrolase; Provisional; Region: PRK13674
1229205004250	UGMP family protein; Validated; Region: PRK09604
1229205004251	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
1229205004252	HI0933-like protein; Region: HI0933_like; pfam03486
1229205004253	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1229205004254	Yqey-like protein; Region: YqeY; pfam09424
1229205004255	DNA primase; Validated; Region: dnaG; PRK05667
1229205004256	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1229205004257	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1229205004258	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1229205004259	active site
1229205004260	metal binding site [ion binding]; metal-binding site
1229205004261	interdomain interaction site; other site
1229205004262	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
1229205004263	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879
1229205004264	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
1229205004265	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1229205004266	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1229205004267	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
1229205004268	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1229205004269	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1229205004270	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1229205004271	DNA binding residues [nucleotide binding]
1229205004272	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
1229205004273	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205004274	The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429
1229205004275	putative dimerization interface [polypeptide binding]; other site
1229205004276	Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978
1229205004277	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1229205004278	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229205004279	substrate binding pocket [chemical binding]; other site
1229205004280	membrane-bound complex binding site; other site
1229205004281	hinge residues; other site
1229205004282	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1229205004283	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205004284	dimer interface [polypeptide binding]; other site
1229205004285	conserved gate region; other site
1229205004286	ABC-ATPase subunit interface; other site
1229205004287	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205004288	dimer interface [polypeptide binding]; other site
1229205004289	conserved gate region; other site
1229205004290	putative PBP binding loops; other site
1229205004291	ABC-ATPase subunit interface; other site
1229205004292	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1229205004293	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1229205004294	Walker A/P-loop; other site
1229205004295	ATP binding site [chemical binding]; other site
1229205004296	Q-loop/lid; other site
1229205004297	ABC transporter signature motif; other site
1229205004298	Walker B; other site
1229205004299	D-loop; other site
1229205004300	H-loop/switch region; other site
1229205004301	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1229205004302	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1229205004303	Bacterial transcriptional regulator; Region: IclR; pfam01614
1229205004304	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
1229205004305	Patatin phospholipase; Region: DUF3734; pfam12536
1229205004306	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
1229205004307	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698
1229205004308	Asp-box motif; other site
1229205004309	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
1229205004310	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1229205004311	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057
1229205004312	L-aspartate oxidase; Provisional; Region: PRK06175
1229205004313	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1229205004314	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
1229205004315	SdhC subunit interface [polypeptide binding]; other site
1229205004316	proximal heme binding site [chemical binding]; other site
1229205004317	cardiolipin binding site; other site
1229205004318	Iron-sulfur protein interface; other site
1229205004319	proximal quinone binding site [chemical binding]; other site
1229205004320	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
1229205004321	SdhD (CybS) interface [polypeptide binding]; other site
1229205004322	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
1229205004323	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205004324	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
1229205004325	putative dimerization interface [polypeptide binding]; other site
1229205004326	putative substrate binding pocket [chemical binding]; other site
1229205004327	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
1229205004328	Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277
1229205004329	dimer interface [polypeptide binding]; other site
1229205004330	Trp docking motif [polypeptide binding]; other site
1229205004331	active site
1229205004332	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229205004333	membrane-bound complex binding site; other site
1229205004334	hinge residues; other site
1229205004335	Cytochrome c; Region: Cytochrom_C; pfam00034
1229205004336	coenzyme PQQ biosynthesis protein PqqD; Region: PQQ_PqqD; TIGR03859
1229205004337	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
1229205004338	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205004339	Walker A motif; other site
1229205004340	ATP binding site [chemical binding]; other site
1229205004341	Walker B motif; other site
1229205004342	arginine finger; other site
1229205004343	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1229205004344	Protein of unknown function (DUF2964); Region: DUF2964; pfam11177
1229205004345	Protein of unknown function (DUF3564); Region: DUF3564; pfam12087
1229205004346	Cytochrome c; Region: Cytochrom_C; cl11414
1229205004347	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
1229205004348	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1229205004349	ligand binding site [chemical binding]; other site
1229205004350	flexible hinge region; other site
1229205004351	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1229205004352	putative switch regulator; other site
1229205004353	non-specific DNA interactions [nucleotide binding]; other site
1229205004354	DNA binding site [nucleotide binding]
1229205004355	sequence specific DNA binding site [nucleotide binding]; other site
1229205004356	putative cAMP binding site [chemical binding]; other site
1229205004357	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1229205004358	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1229205004359	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205004360	active site
1229205004361	phosphorylation site [posttranslational modification]
1229205004362	intermolecular recognition site; other site
1229205004363	dimerization interface [polypeptide binding]; other site
1229205004364	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1229205004365	DNA binding residues [nucleotide binding]
1229205004366	dimerization interface [polypeptide binding]; other site
1229205004367	PAS domain; Region: PAS_9; pfam13426
1229205004368	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1229205004369	putative active site [active]
1229205004370	heme pocket [chemical binding]; other site
1229205004371	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1229205004372	Histidine kinase; Region: HisKA_3; pfam07730
1229205004373	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205004374	ATP binding site [chemical binding]; other site
1229205004375	Mg2+ binding site [ion binding]; other site
1229205004376	G-X-G motif; other site
1229205004377	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1229205004378	Ligand Binding Site [chemical binding]; other site
1229205004379	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
1229205004380	Ligand Binding Site [chemical binding]; other site
1229205004381	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1229205004382	Ligand Binding Site [chemical binding]; other site
1229205004383	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1229205004384	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
1229205004385	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1229205004386	myosin-cross-reactive antigen; Provisional; Region: PRK13977
1229205004387	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1229205004388	Ligand Binding Site [chemical binding]; other site
1229205004389	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
1229205004390	putative FMN binding site [chemical binding]; other site
1229205004391	NADPH bind site [chemical binding]; other site
1229205004392	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1229205004393	FMN binding site [chemical binding]; other site
1229205004394	dimer interface [polypeptide binding]; other site
1229205004395	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
1229205004396	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1229205004397	Beta-Casp domain; Region: Beta-Casp; smart01027
1229205004398	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1229205004399	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1229205004400	alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175
1229205004401	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
1229205004402	BON domain; Region: BON; pfam04972
1229205004403	BON domain; Region: BON; pfam04972
1229205004404	BON domain; Region: BON; pfam04972
1229205004405	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1229205004406	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
1229205004407	NAD binding site [chemical binding]; other site
1229205004408	substrate binding site [chemical binding]; other site
1229205004409	catalytic Zn binding site [ion binding]; other site
1229205004410	tetramer interface [polypeptide binding]; other site
1229205004411	structural Zn binding site [ion binding]; other site
1229205004412	FOG: CBS domain [General function prediction only]; Region: COG0517
1229205004413	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
1229205004414	BON domain; Region: BON; pfam04972
1229205004415	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1229205004416	Ligand Binding Site [chemical binding]; other site
1229205004417	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1229205004418	Ligand Binding Site [chemical binding]; other site
1229205004419	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1229205004420	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1229205004421	N-terminal plug; other site
1229205004422	ligand-binding site [chemical binding]; other site
1229205004423	CsbD-like; Region: CsbD; pfam05532
1229205004424	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1229205004425	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1229205004426	Bacterial transcriptional regulator; Region: IclR; pfam01614
1229205004427	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1229205004428	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1229205004429	active site
1229205004430	catalytic tetrad [active]
1229205004431	hypothetical protein; Provisional; Region: PRK07482
1229205004432	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1229205004433	inhibitor-cofactor binding pocket; inhibition site
1229205004434	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205004435	catalytic residue [active]
1229205004436	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1229205004437	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1229205004438	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
1229205004439	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
1229205004440	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
1229205004441	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
1229205004442	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
1229205004443	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
1229205004444	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1229205004445	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1229205004446	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1229205004447	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205004448	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229205004449	putative substrate translocation pore; other site
1229205004450	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
1229205004451	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
1229205004452	Protein of unknown function (DUF917); Region: DUF917; pfam06032
1229205004453	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
1229205004454	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205004455	Walker A motif; other site
1229205004456	ATP binding site [chemical binding]; other site
1229205004457	Walker B motif; other site
1229205004458	arginine finger; other site
1229205004459	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1229205004460	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
1229205004461	Domain of unknown function (DUF4382); Region: DUF4382; pfam14321
1229205004462	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1229205004463	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205004464	The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481
1229205004465	dimerization interface [polypeptide binding]; other site
1229205004466	substrate binding pocket [chemical binding]; other site
1229205004467	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
1229205004468	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1229205004469	FAD binding domain; Region: FAD_binding_4; pfam01565
1229205004470	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1229205004471	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
1229205004472	aldehyde dehydrogenase family 7 member; Region: PLN02315
1229205004473	tetrameric interface [polypeptide binding]; other site
1229205004474	NAD binding site [chemical binding]; other site
1229205004475	catalytic residues [active]
1229205004476	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1229205004477	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
1229205004478	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229205004479	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205004480	homodimer interface [polypeptide binding]; other site
1229205004481	catalytic residue [active]
1229205004482	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1229205004483	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1229205004484	DNA binding site [nucleotide binding]
1229205004485	domain linker motif; other site
1229205004486	This group includes the ligand-binding domain of putative DNA transcription repressors which are highly similar to that of the repressor specific for gluconate (GntR), a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_1; cd06273
1229205004487	putative ligand binding site [chemical binding]; other site
1229205004488	putative dimerization interface [polypeptide binding]; other site
1229205004489	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1229205004490	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1229205004491	inhibitor site; inhibition site
1229205004492	active site
1229205004493	dimer interface [polypeptide binding]; other site
1229205004494	catalytic residue [active]
1229205004495	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205004496	D-galactonate transporter; Region: 2A0114; TIGR00893
1229205004497	putative substrate translocation pore; other site
1229205004498	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205004499	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205004500	eyelet of channel; other site
1229205004501	trimer interface [polypeptide binding]; other site
1229205004502	Cache domain; Region: Cache_2; pfam08269
1229205004503	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1229205004504	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1229205004505	dimer interface [polypeptide binding]; other site
1229205004506	putative CheW interface [polypeptide binding]; other site
1229205004507	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1229205004508	DNA-binding site [nucleotide binding]; DNA binding site
1229205004509	RNA-binding motif; other site
1229205004510	LysE type translocator; Region: LysE; cl00565
1229205004511	DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916
1229205004512	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
1229205004513	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1229205004514	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1229205004515	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
1229205004516	active site
1229205004517	heterodimer interface [polypeptide binding]; other site
1229205004518	Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464
1229205004519	heterodimer interface [polypeptide binding]; other site
1229205004520	multimer interface [polypeptide binding]; other site
1229205004521	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
1229205004522	active site
1229205004523	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
1229205004524	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205004525	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
1229205004526	putative dimerization interface [polypeptide binding]; other site
1229205004527	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
1229205004528	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
1229205004529	dimer interface [polypeptide binding]; other site
1229205004530	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
1229205004531	active site
1229205004532	Fe binding site [ion binding]; other site
1229205004533	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1229205004534	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229205004535	non-specific DNA binding site [nucleotide binding]; other site
1229205004536	salt bridge; other site
1229205004537	sequence-specific DNA binding site [nucleotide binding]; other site
1229205004538	Cupin domain; Region: Cupin_2; pfam07883
1229205004539	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1229205004540	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1229205004541	dimer interface [polypeptide binding]; other site
1229205004542	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
1229205004543	putative CheW interface [polypeptide binding]; other site
1229205004544	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
1229205004545	hydrophobic ligand binding site; other site
1229205004546	proteobacterial dedicated sortase system response regulator; Region: marine_sort_RR; TIGR03787
1229205004547	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205004548	active site
1229205004549	phosphorylation site [posttranslational modification]
1229205004550	intermolecular recognition site; other site
1229205004551	dimerization interface [polypeptide binding]; other site
1229205004552	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229205004553	DNA binding site [nucleotide binding]
1229205004554	CHASE2 domain; Region: CHASE2; pfam05226
1229205004555	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1229205004556	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1229205004557	dimer interface [polypeptide binding]; other site
1229205004558	phosphorylation site [posttranslational modification]
1229205004559	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205004560	ATP binding site [chemical binding]; other site
1229205004561	Mg2+ binding site [ion binding]; other site
1229205004562	G-X-G motif; other site
1229205004563	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
1229205004564	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
1229205004565	trimer interface [polypeptide binding]; other site
1229205004566	YadA-like C-terminal region; Region: YadA; pfam03895
1229205004567	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
1229205004568	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1229205004569	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1229205004570	ligand binding site [chemical binding]; other site
1229205004571	hypothetical protein; Provisional; Region: PRK11281
1229205004572	Predicted membrane protein; Region: Transmemb_17; pfam09799
1229205004573	Cache domain; Region: Cache_1; pfam02743
1229205004574	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1229205004575	dimerization interface [polypeptide binding]; other site
1229205004576	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1229205004577	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1229205004578	dimer interface [polypeptide binding]; other site
1229205004579	putative CheW interface [polypeptide binding]; other site
1229205004580	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
1229205004581	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
1229205004582	active site
1229205004583	catalytic residues [active]
1229205004584	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
1229205004585	putative dimerization interface [polypeptide binding]; other site
1229205004586	putative ligand binding site [chemical binding]; other site
1229205004587	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1229205004588	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1229205004589	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205004590	xylose isomerase; Provisional; Region: PRK05474
1229205004591	xylose isomerase; Region: xylose_isom_A; TIGR02630
1229205004592	D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634
1229205004593	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
1229205004594	putative ligand binding site [chemical binding]; other site
1229205004595	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
1229205004596	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1229205004597	Walker A/P-loop; other site
1229205004598	ATP binding site [chemical binding]; other site
1229205004599	Q-loop/lid; other site
1229205004600	ABC transporter signature motif; other site
1229205004601	Walker B; other site
1229205004602	D-loop; other site
1229205004603	H-loop/switch region; other site
1229205004604	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1229205004605	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1229205004606	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1229205004607	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1229205004608	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1229205004609	TM-ABC transporter signature motif; other site
1229205004610	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1229205004611	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1229205004612	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1229205004613	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1229205004614	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
1229205004615	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1229205004616	catalytic loop [active]
1229205004617	iron binding site [ion binding]; other site
1229205004618	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1229205004619	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1229205004620	p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559
1229205004621	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1229205004622	HlyD family secretion protein; Region: HlyD_3; pfam13437
1229205004623	Fusaric acid resistance protein family; Region: FUSC; pfam04632
1229205004624	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1229205004625	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1229205004626	Protein-interacting Bro1-like domain of mammalian Alix and related domains; Region: BRO1_Alix_like; cl14649
1229205004627	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
1229205004628	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205004629	dimer interface [polypeptide binding]; other site
1229205004630	phosphorylation site [posttranslational modification]
1229205004631	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205004632	ATP binding site [chemical binding]; other site
1229205004633	Mg2+ binding site [ion binding]; other site
1229205004634	G-X-G motif; other site
1229205004635	Response regulator receiver domain; Region: Response_reg; pfam00072
1229205004636	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205004637	active site
1229205004638	phosphorylation site [posttranslational modification]
1229205004639	intermolecular recognition site; other site
1229205004640	dimerization interface [polypeptide binding]; other site
1229205004641	circadian clock protein KaiC; Region: circ_KaiC; TIGR02655
1229205004642	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1229205004643	Walker A motif; other site
1229205004644	ATP binding site [chemical binding]; other site
1229205004645	Walker B motif; other site
1229205004646	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1229205004647	Walker A motif; other site
1229205004648	ATP binding site [chemical binding]; other site
1229205004649	Walker B motif; other site
1229205004650	Phosphoglycerate mutase family; Region: PGAM; smart00855
1229205004651	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1229205004652	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
1229205004653	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826
1229205004654	Uncharacterized protein conserved in bacteria (DUF2138); Region: DUF2138; pfam09909
1229205004655	Protein of unknown function (DUF1175); Region: DUF1175; cl14898
1229205004656	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
1229205004657	MG2 domain; Region: A2M_N; pfam01835
1229205004658	Alpha-2-macroglobulin family; Region: A2M; pfam00207
1229205004659	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
1229205004660	Predicted secreted protein [Function unknown]; Region: COG5445
1229205004661	Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062
1229205004662	Stage II sporulation protein; Region: SpoIID; pfam08486
1229205004663	Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062
1229205004664	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676
1229205004665	Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906
1229205004666	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676
1229205004667	Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906
1229205004668	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
1229205004669	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1229205004670	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1229205004671	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
1229205004672	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1229205004673	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1229205004674	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1229205004675	DNA binding residues [nucleotide binding]
1229205004676	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1229205004677	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205004678	DNA-binding site [nucleotide binding]; DNA binding site
1229205004679	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1229205004680	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1229205004681	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
1229205004682	putative ligand binding site [chemical binding]; other site
1229205004683	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1229205004684	TM-ABC transporter signature motif; other site
1229205004685	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1229205004686	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1229205004687	TM-ABC transporter signature motif; other site
1229205004688	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1229205004689	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1229205004690	Walker A/P-loop; other site
1229205004691	ATP binding site [chemical binding]; other site
1229205004692	Q-loop/lid; other site
1229205004693	ABC transporter signature motif; other site
1229205004694	Walker B; other site
1229205004695	D-loop; other site
1229205004696	H-loop/switch region; other site
1229205004697	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1229205004698	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1229205004699	Walker A/P-loop; other site
1229205004700	ATP binding site [chemical binding]; other site
1229205004701	Q-loop/lid; other site
1229205004702	ABC transporter signature motif; other site
1229205004703	Walker B; other site
1229205004704	D-loop; other site
1229205004705	H-loop/switch region; other site
1229205004706	allantoate amidohydrolase; Reviewed; Region: PRK12893
1229205004707	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
1229205004708	active site
1229205004709	metal binding site [ion binding]; metal-binding site
1229205004710	dimer interface [polypeptide binding]; other site
1229205004711	Uncharacterized conserved protein [Function unknown]; Region: COG5476
1229205004712	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
1229205004713	MlrC C-terminus; Region: MlrC_C; pfam07171
1229205004714	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
1229205004715	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1229205004716	active site
1229205004717	benzoate transport; Region: 2A0115; TIGR00895
1229205004718	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205004719	putative substrate translocation pore; other site
1229205004720	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1229205004721	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205004722	DNA-binding site [nucleotide binding]; DNA binding site
1229205004723	UTRA domain; Region: UTRA; pfam07702
1229205004724	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229205004725	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205004726	putative substrate translocation pore; other site
1229205004727	Predicted permease; Region: DUF318; cl17795
1229205004728	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
1229205004729	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1229205004730	active site residue [active]
1229205004731	AAA domain; Region: AAA_17; cl17253
1229205004732	selenophosphate synthetase; Provisional; Region: PRK00943
1229205004733	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
1229205004734	dimerization interface [polypeptide binding]; other site
1229205004735	putative ATP binding site [chemical binding]; other site
1229205004736	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
1229205004737	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1229205004738	PYR/PP interface [polypeptide binding]; other site
1229205004739	dimer interface [polypeptide binding]; other site
1229205004740	TPP binding site [chemical binding]; other site
1229205004741	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1229205004742	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1229205004743	TPP-binding site [chemical binding]; other site
1229205004744	dimer interface [polypeptide binding]; other site
1229205004745	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205004746	D-galactonate transporter; Region: 2A0114; TIGR00893
1229205004747	putative substrate translocation pore; other site
1229205004748	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1229205004749	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205004750	NAD(P) binding site [chemical binding]; other site
1229205004751	active site
1229205004752	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1229205004753	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205004754	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1229205004755	dimerization interface [polypeptide binding]; other site
1229205004756	substrate binding pocket [chemical binding]; other site
1229205004757	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1229205004758	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229205004759	Walker A/P-loop; other site
1229205004760	ATP binding site [chemical binding]; other site
1229205004761	Q-loop/lid; other site
1229205004762	ABC transporter signature motif; other site
1229205004763	Walker B; other site
1229205004764	D-loop; other site
1229205004765	H-loop/switch region; other site
1229205004766	Protein of unknown function (DUF3005); Region: DUF3005; pfam11448
1229205004767	Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977
1229205004768	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
1229205004769	TadE-like protein; Region: TadE; pfam07811
1229205004770	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
1229205004771	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1229205004772	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
1229205004773	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1229205004774	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
1229205004775	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1229205004776	ATP binding site [chemical binding]; other site
1229205004777	Walker A motif; other site
1229205004778	hexamer interface [polypeptide binding]; other site
1229205004779	Walker B motif; other site
1229205004780	Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
1229205004781	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
1229205004782	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
1229205004783	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
1229205004784	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
1229205004785	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1229205004786	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
1229205004787	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
1229205004788	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205004789	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1229205004790	Walker A motif; other site
1229205004791	ATP binding site [chemical binding]; other site
1229205004792	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
1229205004793	Flp/Fap pilin component; Region: Flp_Fap; pfam04964
1229205004794	succinic semialdehyde dehydrogenase; Region: PLN02278
1229205004795	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1229205004796	tetramerization interface [polypeptide binding]; other site
1229205004797	NAD(P) binding site [chemical binding]; other site
1229205004798	catalytic residues [active]
1229205004799	Domain of unknown function (DUF4071); Region: DUF4071; pfam13281
1229205004800	benzoate transport; Region: 2A0115; TIGR00895
1229205004801	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205004802	putative substrate translocation pore; other site
1229205004803	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205004804	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_7; cd06910
1229205004805	putative active site [active]
1229205004806	Zn binding site [ion binding]; other site
1229205004807	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
1229205004808	tartrate dehydrogenase; Region: TTC; TIGR02089
1229205004809	transcriptional activator TtdR; Provisional; Region: PRK09801
1229205004810	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205004811	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
1229205004812	putative effector binding pocket; other site
1229205004813	putative dimerization interface [polypeptide binding]; other site
1229205004814	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1229205004815	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1229205004816	putative DNA binding site [nucleotide binding]; other site
1229205004817	putative Zn2+ binding site [ion binding]; other site
1229205004818	AsnC family; Region: AsnC_trans_reg; pfam01037
1229205004819	hypothetical protein; Provisional; Region: PRK05965
1229205004820	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1229205004821	inhibitor-cofactor binding pocket; inhibition site
1229205004822	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205004823	catalytic residue [active]
1229205004824	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1229205004825	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
1229205004826	putative ligand binding site [chemical binding]; other site
1229205004827	NAD binding site [chemical binding]; other site
1229205004828	dimerization interface [polypeptide binding]; other site
1229205004829	catalytic site [active]
1229205004830	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1229205004831	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229205004832	Coenzyme A binding pocket [chemical binding]; other site
1229205004833	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1229205004834	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1229205004835	NAD(P) binding site [chemical binding]; other site
1229205004836	catalytic residues [active]
1229205004837	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
1229205004838	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229205004839	motif II; other site
1229205004840	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1229205004841	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1229205004842	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1229205004843	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
1229205004844	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1229205004845	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205004846	dimer interface [polypeptide binding]; other site
1229205004847	conserved gate region; other site
1229205004848	putative PBP binding loops; other site
1229205004849	ABC-ATPase subunit interface; other site
1229205004850	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1229205004851	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205004852	dimer interface [polypeptide binding]; other site
1229205004853	conserved gate region; other site
1229205004854	ABC-ATPase subunit interface; other site
1229205004855	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1229205004856	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1229205004857	Walker A/P-loop; other site
1229205004858	ATP binding site [chemical binding]; other site
1229205004859	Q-loop/lid; other site
1229205004860	ABC transporter signature motif; other site
1229205004861	Walker B; other site
1229205004862	D-loop; other site
1229205004863	H-loop/switch region; other site
1229205004864	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1229205004865	Walker A/P-loop; other site
1229205004866	ATP binding site [chemical binding]; other site
1229205004867	Q-loop/lid; other site
1229205004868	ABC transporter signature motif; other site
1229205004869	Walker B; other site
1229205004870	D-loop; other site
1229205004871	H-loop/switch region; other site
1229205004872	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1229205004873	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
1229205004874	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1229205004875	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1229205004876	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1229205004877	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1229205004878	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1229205004879	Propionate catabolism activator; Region: PrpR_N; pfam06506
1229205004880	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
1229205004881	PAS domain; Region: PAS; smart00091
1229205004882	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205004883	Walker A motif; other site
1229205004884	ATP binding site [chemical binding]; other site
1229205004885	Walker B motif; other site
1229205004886	arginine finger; other site
1229205004887	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1229205004888	coenzyme A binding site [chemical binding]; other site
1229205004889	citrylCoA binding site [chemical binding]; other site
1229205004890	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
1229205004891	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1229205004892	oxalacetate binding site [chemical binding]; other site
1229205004893	catalytic triad [active]
1229205004894	2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333
1229205004895	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
1229205004896	substrate binding site [chemical binding]; other site
1229205004897	ligand binding site [chemical binding]; other site
1229205004898	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
1229205004899	substrate binding site [chemical binding]; other site
1229205004900	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
1229205004901	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544
1229205004902	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1229205004903	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229205004904	binding surface
1229205004905	TPR motif; other site
1229205004906	TPR repeat; Region: TPR_11; pfam13414
1229205004907	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229205004908	binding surface
1229205004909	TPR motif; other site
1229205004910	ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782
1229205004911	GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914
1229205004912	GDP-Fucose binding site [chemical binding]; other site
1229205004913	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
1229205004914	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1229205004915	putative NAD(P) binding site [chemical binding]; other site
1229205004916	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1229205004917	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229205004918	Walker A/P-loop; other site
1229205004919	ATP binding site [chemical binding]; other site
1229205004920	Q-loop/lid; other site
1229205004921	ABC transporter signature motif; other site
1229205004922	Walker B; other site
1229205004923	D-loop; other site
1229205004924	H-loop/switch region; other site
1229205004925	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1229205004926	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205004927	Walker A motif; other site
1229205004928	ATP binding site [chemical binding]; other site
1229205004929	Walker B motif; other site
1229205004930	arginine finger; other site
1229205004931	Peptidase family M41; Region: Peptidase_M41; pfam01434
1229205004932	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1229205004933	OpgC protein; Region: OpgC_C; pfam10129
1229205004934	Tannase and feruloyl esterase; Region: Tannase; pfam07519
1229205004935	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1229205004936	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1229205004937	Walker A/P-loop; other site
1229205004938	ATP binding site [chemical binding]; other site
1229205004939	Q-loop/lid; other site
1229205004940	ABC transporter signature motif; other site
1229205004941	Walker B; other site
1229205004942	D-loop; other site
1229205004943	H-loop/switch region; other site
1229205004944	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1229205004945	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1229205004946	DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188
1229205004947	Autoinducer binding domain; Region: Autoind_bind; pfam03472
1229205004948	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1229205004949	DNA binding residues [nucleotide binding]
1229205004950	dimerization interface [polypeptide binding]; other site
1229205004951	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1229205004952	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205004953	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205004954	Protein of unknown function (DUF3830); Region: DUF3830; pfam12903
1229205004955	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
1229205004956	Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295
1229205004957	YadA-like C-terminal region; Region: YadA; pfam03895
1229205004958	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
1229205004959	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205004960	shikimate transporter; Provisional; Region: PRK09952
1229205004961	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205004962	putative substrate translocation pore; other site
1229205004963	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1229205004964	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205004965	DNA-binding site [nucleotide binding]; DNA binding site
1229205004966	FCD domain; Region: FCD; pfam07729
1229205004967	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
1229205004968	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1229205004969	PYR/PP interface [polypeptide binding]; other site
1229205004970	dimer interface [polypeptide binding]; other site
1229205004971	TPP binding site [chemical binding]; other site
1229205004972	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1229205004973	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
1229205004974	TPP-binding site; other site
1229205004975	dimer interface [polypeptide binding]; other site
1229205004976	formyl-coenzyme A transferase; Provisional; Region: PRK05398
1229205004977	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1229205004978	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
1229205004979	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
1229205004980	CoA binding domain; Region: CoA_binding_2; pfam13380
1229205004981	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
1229205004982	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1229205004983	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1229205004984	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
1229205004985	Autophagy protein Apg6; Region: APG6; pfam04111
1229205004986	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205004987	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205004988	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
1229205004989	putative dimerization interface [polypeptide binding]; other site
1229205004990	oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259
1229205004991	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205004992	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205004993	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
1229205004994	putative dimerization interface [polypeptide binding]; other site
1229205004995	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1229205004996	Pseudomonas fluorescens 4-hydroxymuconic semialdehyde dehydrogenase-like; Region: ALDH_HMSADH_HapE; cd07115
1229205004997	NAD(P) binding site [chemical binding]; other site
1229205004998	catalytic residues [active]
1229205004999	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1229205005000	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1229205005001	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1229205005002	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1229205005003	Uncharacterized conserved protein [Function unknown]; Region: COG1739
1229205005004	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1229205005005	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1229205005006	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1229205005007	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
1229205005008	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
1229205005009	putative catalytic residue [active]
1229205005010	Protein of unknown function (DUF2866); Region: DUF2866; pfam11065
1229205005011	Protein of unknown function, DUF484; Region: DUF484; cl17449
1229205005012	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1229205005013	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1229205005014	metal binding site [ion binding]; metal-binding site
1229205005015	active site
1229205005016	I-site; other site
1229205005017	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1229205005018	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1229205005019	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1229205005020	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
1229205005021	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1229205005022	HAMP domain; Region: HAMP; pfam00672
1229205005023	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1229205005024	dimer interface [polypeptide binding]; other site
1229205005025	putative CheW interface [polypeptide binding]; other site
1229205005026	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1229205005027	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1229205005028	tetramer interface [polypeptide binding]; other site
1229205005029	active site
1229205005030	Mg2+/Mn2+ binding site [ion binding]; other site
1229205005031	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
1229205005032	active site
1229205005033	metal-binding site
1229205005034	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1229205005035	phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297
1229205005036	PYR/PP interface [polypeptide binding]; other site
1229205005037	dimer interface [polypeptide binding]; other site
1229205005038	TPP binding site [chemical binding]; other site
1229205005039	Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as...; Region: TPP_PpyrDC; cd03371
1229205005040	TPP-binding site; other site
1229205005041	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1229205005042	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1229205005043	catalytic residue [active]
1229205005044	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
1229205005045	Domain of unknown function (DUF4130; Region: DUF4130; cl14836
1229205005046	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
1229205005047	Fe-S cluster binding site [ion binding]; other site
1229205005048	active site
1229205005049	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
1229205005050	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
1229205005051	Ligand binding site; other site
1229205005052	metal-binding site
1229205005053	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1229205005054	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1229205005055	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1229205005056	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
1229205005057	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
1229205005058	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1229205005059	catalytic loop [active]
1229205005060	iron binding site [ion binding]; other site
1229205005061	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1229205005062	3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605
1229205005063	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
1229205005064	putative catalytic site [active]
1229205005065	putative phosphate binding site [ion binding]; other site
1229205005066	active site
1229205005067	metal binding site A [ion binding]; metal-binding site
1229205005068	DNA binding site [nucleotide binding]
1229205005069	putative AP binding site [nucleotide binding]; other site
1229205005070	putative metal binding site B [ion binding]; other site
1229205005071	flagellar motor protein MotB; Validated; Region: motB; PRK09041
1229205005072	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
1229205005073	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1229205005074	ligand binding site [chemical binding]; other site
1229205005075	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
1229205005076	flagellar motor stator protein MotA; Region: MotA1; TIGR03818
1229205005077	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
1229205005078	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
1229205005079	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1229205005080	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
1229205005081	NodB motif; other site
1229205005082	active site
1229205005083	catalytic site [active]
1229205005084	metal binding site [ion binding]; metal-binding site
1229205005085	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1229205005086	classical (c) SDRs; Region: SDR_c; cd05233
1229205005087	NAD(P) binding site [chemical binding]; other site
1229205005088	active site
1229205005089	Oxidoreductase-like protein, N-terminal; Region: Oxidored-like; pfam09791
1229205005090	NAD-dependent deacetylase; Provisional; Region: PRK05333
1229205005091	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
1229205005092	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1229205005093	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229205005094	S-adenosylmethionine binding site [chemical binding]; other site
1229205005095	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1229205005096	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
1229205005097	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1229205005098	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
1229205005099	Protein of unknown function (DUF2968); Region: DUF2968; pfam11180
1229205005100	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
1229205005101	Cupin domain; Region: Cupin_2; cl17218
1229205005102	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1229205005103	Peptidase family M23; Region: Peptidase_M23; pfam01551
1229205005104	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
1229205005105	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
1229205005106	tetramer interface [polypeptide binding]; other site
1229205005107	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205005108	catalytic residue [active]
1229205005109	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205005110	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205005111	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
1229205005112	homodimer interface [polypeptide binding]; other site
1229205005113	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
1229205005114	active site pocket [active]
1229205005115	cell density-dependent motility repressor; Provisional; Region: PRK10082
1229205005116	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205005117	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1229205005118	dimerization interface [polypeptide binding]; other site
1229205005119	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1229205005120	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
1229205005121	aspartate racemase; Region: asp_race; TIGR00035
1229205005122	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177
1229205005123	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
1229205005124	aspartate racemase; Region: asp_race; TIGR00035
1229205005125	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
1229205005126	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205005127	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205005128	dimerization interface [polypeptide binding]; other site
1229205005129	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1229205005130	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229205005131	Walker A/P-loop; other site
1229205005132	ATP binding site [chemical binding]; other site
1229205005133	Q-loop/lid; other site
1229205005134	ABC transporter signature motif; other site
1229205005135	Walker B; other site
1229205005136	D-loop; other site
1229205005137	H-loop/switch region; other site
1229205005138	TOBE domain; Region: TOBE_2; pfam08402
1229205005139	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
1229205005140	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
1229205005141	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1229205005142	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1229205005143	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205005144	dimer interface [polypeptide binding]; other site
1229205005145	conserved gate region; other site
1229205005146	putative PBP binding loops; other site
1229205005147	ABC-ATPase subunit interface; other site
1229205005148	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1229205005149	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205005150	dimer interface [polypeptide binding]; other site
1229205005151	conserved gate region; other site
1229205005152	putative PBP binding loops; other site
1229205005153	ABC-ATPase subunit interface; other site
1229205005154	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
1229205005155	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1229205005156	NAD binding site [chemical binding]; other site
1229205005157	catalytic residues [active]
1229205005158	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1229205005159	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1229205005160	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1229205005161	hypothetical protein; Provisional; Region: PRK11622
1229205005162	RNA polymerase sigma factor; Provisional; Region: PRK11922
1229205005163	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1229205005164	DNA binding residues [nucleotide binding]
1229205005165	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
1229205005166	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
1229205005167	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1229205005168	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205005169	putative substrate translocation pore; other site
1229205005170	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
1229205005171	tartrate dehydrogenase; Region: TTC; TIGR02089
1229205005172	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205005173	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
1229205005174	putative effector binding pocket; other site
1229205005175	putative dimerization interface [polypeptide binding]; other site
1229205005176	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
1229205005177	C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716
1229205005178	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229205005179	S-adenosylmethionine binding site [chemical binding]; other site
1229205005180	sensor protein QseC; Provisional; Region: PRK10337
1229205005181	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205005182	dimer interface [polypeptide binding]; other site
1229205005183	phosphorylation site [posttranslational modification]
1229205005184	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205005185	Mg2+ binding site [ion binding]; other site
1229205005186	G-X-G motif; other site
1229205005187	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1229205005188	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205005189	active site
1229205005190	phosphorylation site [posttranslational modification]
1229205005191	intermolecular recognition site; other site
1229205005192	dimerization interface [polypeptide binding]; other site
1229205005193	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229205005194	DNA binding site [nucleotide binding]
1229205005195	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
1229205005196	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705
1229205005197	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
1229205005198	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
1229205005199	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
1229205005200	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205005201	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205005202	trimer interface [polypeptide binding]; other site
1229205005203	eyelet of channel; other site
1229205005204	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1229205005205	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1229205005206	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
1229205005207	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
1229205005208	active site
1229205005209	Zn binding site [ion binding]; other site
1229205005210	ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010
1229205005211	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229205005212	substrate binding pocket [chemical binding]; other site
1229205005213	membrane-bound complex binding site; other site
1229205005214	hinge residues; other site
1229205005215	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1229205005216	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1229205005217	HAMP domain; Region: HAMP; pfam00672
1229205005218	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1229205005219	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1229205005220	metal binding site [ion binding]; metal-binding site
1229205005221	active site
1229205005222	I-site; other site
1229205005223	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1229205005224	Guanylate kinase; Region: Guanylate_kin; pfam00625
1229205005225	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1229205005226	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
1229205005227	metal binding site [ion binding]; metal-binding site
1229205005228	putative dimer interface [polypeptide binding]; other site
1229205005229	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
1229205005230	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1229205005231	Bacterial transcriptional regulator; Region: IclR; pfam01614
1229205005232	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1229205005233	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205005234	DNA-binding site [nucleotide binding]; DNA binding site
1229205005235	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1229205005236	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1229205005237	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1229205005238	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
1229205005239	putative aldolase; Validated; Region: PRK08130
1229205005240	intersubunit interface [polypeptide binding]; other site
1229205005241	active site
1229205005242	Zn2+ binding site [ion binding]; other site
1229205005243	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1229205005244	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205005245	putative substrate translocation pore; other site
1229205005246	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
1229205005247	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1229205005248	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
1229205005249	putative NAD(P) binding site [chemical binding]; other site
1229205005250	active site
1229205005251	putative substrate binding site [chemical binding]; other site
1229205005252	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
1229205005253	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1229205005254	dimer interface [polypeptide binding]; other site
1229205005255	active site
1229205005256	Protein of unknown function (DUF2917); Region: DUF2917; pfam11142
1229205005257	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229205005258	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205005259	dimer interface [polypeptide binding]; other site
1229205005260	phosphorylation site [posttranslational modification]
1229205005261	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205005262	ATP binding site [chemical binding]; other site
1229205005263	Mg2+ binding site [ion binding]; other site
1229205005264	G-X-G motif; other site
1229205005265	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205005266	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
1229205005267	putative effector binding pocket; other site
1229205005268	putative dimerization interface [polypeptide binding]; other site
1229205005269	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1229205005270	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1229205005271	active site
1229205005272	catalytic tetrad [active]
1229205005273	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205005274	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461
1229205005275	putative substrate binding pocket [chemical binding]; other site
1229205005276	putative dimerization interface [polypeptide binding]; other site
1229205005277	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
1229205005278	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1229205005279	Predicted esterase [General function prediction only]; Region: COG0627
1229205005280	S-formylglutathione hydrolase; Region: PLN02442
1229205005281	aspartate carbamoyltransferase; Provisional; Region: PRK11891
1229205005282	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1229205005283	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1229205005284	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1229205005285	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1229205005286	dimer interface [polypeptide binding]; other site
1229205005287	active site
1229205005288	catalytic residue [active]
1229205005289	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1229205005290	Peptidase family M23; Region: Peptidase_M23; pfam01551
1229205005291	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
1229205005292	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
1229205005293	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
1229205005294	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
1229205005295	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1229205005296	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1229205005297	metal binding site [ion binding]; metal-binding site
1229205005298	active site
1229205005299	I-site; other site
1229205005300	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1229205005301	Predicted metalloprotease [General function prediction only]; Region: COG2321
1229205005302	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
1229205005303	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1229205005304	active site residue [active]
1229205005305	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
1229205005306	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1229205005307	conserved cys residue [active]
1229205005308	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205005309	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
1229205005310	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
1229205005311	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1229205005312	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1229205005313	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1229205005314	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1229205005315	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1229205005316	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205005317	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205005318	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427
1229205005319	putative dimerization interface [polypeptide binding]; other site
1229205005320	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357
1229205005321	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1229205005322	putative metal binding site [ion binding]; other site
1229205005323	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1229205005324	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1229205005325	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1229205005326	HlyD family secretion protein; Region: HlyD_3; pfam13437
1229205005327	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1229205005328	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
1229205005329	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205005330	active site
1229205005331	phosphorylation site [posttranslational modification]
1229205005332	intermolecular recognition site; other site
1229205005333	dimerization interface [polypeptide binding]; other site
1229205005334	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229205005335	DNA binding site [nucleotide binding]
1229205005336	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
1229205005337	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205005338	dimer interface [polypeptide binding]; other site
1229205005339	phosphorylation site [posttranslational modification]
1229205005340	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205005341	ATP binding site [chemical binding]; other site
1229205005342	Mg2+ binding site [ion binding]; other site
1229205005343	G-X-G motif; other site
1229205005344	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1229205005345	active site
1229205005346	DNA polymerase IV; Validated; Region: PRK02406
1229205005347	DNA binding site [nucleotide binding]
1229205005348	Uncharacterized conserved protein [Function unknown]; Region: COG2353
1229205005349	YceI-like domain; Region: YceI; smart00867
1229205005350	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
1229205005351	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
1229205005352	transmembrane helices; other site
1229205005353	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
1229205005354	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
1229205005355	pseudo EF-hand loop; other site
1229205005356	peptide binding pocket; other site
1229205005357	Ca2+ binding site [ion binding]; other site
1229205005358	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1229205005359	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1229205005360	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1229205005361	HlyD family secretion protein; Region: HlyD_3; pfam13437
1229205005362	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1229205005363	osmolarity response regulator; Provisional; Region: ompR; PRK09468
1229205005364	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205005365	active site
1229205005366	phosphorylation site [posttranslational modification]
1229205005367	intermolecular recognition site; other site
1229205005368	dimerization interface [polypeptide binding]; other site
1229205005369	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229205005370	DNA binding site [nucleotide binding]
1229205005371	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1229205005372	dimerization interface [polypeptide binding]; other site
1229205005373	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205005374	dimer interface [polypeptide binding]; other site
1229205005375	phosphorylation site [posttranslational modification]
1229205005376	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205005377	ATP binding site [chemical binding]; other site
1229205005378	Mg2+ binding site [ion binding]; other site
1229205005379	G-X-G motif; other site
1229205005380	PAS fold; Region: PAS_4; pfam08448
1229205005381	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1229205005382	PAS fold; Region: PAS_3; pfam08447
1229205005383	putative active site [active]
1229205005384	heme pocket [chemical binding]; other site
1229205005385	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205005386	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229205005387	dimer interface [polypeptide binding]; other site
1229205005388	phosphorylation site [posttranslational modification]
1229205005389	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205005390	ATP binding site [chemical binding]; other site
1229205005391	G-X-G motif; other site
1229205005392	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1229205005393	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205005394	active site
1229205005395	phosphorylation site [posttranslational modification]
1229205005396	intermolecular recognition site; other site
1229205005397	dimerization interface [polypeptide binding]; other site
1229205005398	Response regulator receiver domain; Region: Response_reg; pfam00072
1229205005399	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205005400	active site
1229205005401	phosphorylation site [posttranslational modification]
1229205005402	intermolecular recognition site; other site
1229205005403	dimerization interface [polypeptide binding]; other site
1229205005404	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
1229205005405	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
1229205005406	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229205005407	binding surface
1229205005408	TPR motif; other site
1229205005409	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
1229205005410	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229205005411	TPR motif; other site
1229205005412	binding surface
1229205005413	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229205005414	TPR motif; other site
1229205005415	binding surface
1229205005416	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229205005417	TPR motif; other site
1229205005418	binding surface
1229205005419	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
1229205005420	endo-1,4-D-glucanase; Provisional; Region: PRK11097
1229205005421	cellulose synthase regulator protein; Provisional; Region: PRK11114
1229205005422	cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030
1229205005423	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
1229205005424	DXD motif; other site
1229205005425	PilZ domain; Region: PilZ; pfam07238
1229205005426	cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371
1229205005427	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1229205005428	P-loop; other site
1229205005429	Magnesium ion binding site [ion binding]; other site
1229205005430	Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500
1229205005431	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1229205005432	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1229205005433	metal binding site [ion binding]; metal-binding site
1229205005434	active site
1229205005435	I-site; other site
1229205005436	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1229205005437	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
1229205005438	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
1229205005439	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
1229205005440	putative substrate binding pocket [chemical binding]; other site
1229205005441	trimer interface [polypeptide binding]; other site
1229205005442	The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370
1229205005443	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
1229205005444	putative active site [active]
1229205005445	putative metal binding site [ion binding]; other site
1229205005446	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299
1229205005447	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
1229205005448	NAD binding site [chemical binding]; other site
1229205005449	catalytic residues [active]
1229205005450	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
1229205005451	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1229205005452	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
1229205005453	MarR family; Region: MarR_2; cl17246
1229205005454	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1229205005455	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205005456	metabolite-proton symporter; Region: 2A0106; TIGR00883
1229205005457	putative substrate translocation pore; other site
1229205005458	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1229205005459	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
1229205005460	tetrameric interface [polypeptide binding]; other site
1229205005461	NAD binding site [chemical binding]; other site
1229205005462	catalytic residues [active]
1229205005463	H+ Antiporter protein; Region: 2A0121; TIGR00900
1229205005464	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205005465	putative substrate translocation pore; other site
1229205005466	Isochorismatase family; Region: Isochorismatase; pfam00857
1229205005467	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1229205005468	catalytic triad [active]
1229205005469	conserved cis-peptide bond; other site
1229205005470	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1229205005471	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1229205005472	putative DNA binding site [nucleotide binding]; other site
1229205005473	putative Zn2+ binding site [ion binding]; other site
1229205005474	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1229205005475	metal binding site [ion binding]; metal-binding site
1229205005476	active site
1229205005477	I-site; other site
1229205005478	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1229205005479	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
1229205005480	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
1229205005481	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1229205005482	N-terminal plug; other site
1229205005483	ligand-binding site [chemical binding]; other site
1229205005484	CsbD-like; Region: CsbD; pfam05532
1229205005485	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
1229205005486	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1229205005487	NAD binding site [chemical binding]; other site
1229205005488	catalytic Zn binding site [ion binding]; other site
1229205005489	structural Zn binding site [ion binding]; other site
1229205005490	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1229205005491	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1229205005492	ATP binding site [chemical binding]; other site
1229205005493	putative Mg++ binding site [ion binding]; other site
1229205005494	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1229205005495	nucleotide binding region [chemical binding]; other site
1229205005496	ATP-binding site [chemical binding]; other site
1229205005497	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
1229205005498	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1229205005499	NAD binding site [chemical binding]; other site
1229205005500	putative substrate binding site 2 [chemical binding]; other site
1229205005501	putative substrate binding site 1 [chemical binding]; other site
1229205005502	active site
1229205005503	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1229205005504	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229205005505	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1229205005506	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1229205005507	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1229205005508	putative active site [active]
1229205005509	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1229205005510	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1229205005511	active site
1229205005512	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1229205005513	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
1229205005514	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
1229205005515	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
1229205005516	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1229205005517	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1229205005518	putative active site [active]
1229205005519	D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213
1229205005520	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229205005521	active site
1229205005522	motif I; other site
1229205005523	motif II; other site
1229205005524	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
1229205005525	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
1229205005526	putative ADP-binding pocket [chemical binding]; other site
1229205005527	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1229205005528	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
1229205005529	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229205005530	Walker A/P-loop; other site
1229205005531	ATP binding site [chemical binding]; other site
1229205005532	Q-loop/lid; other site
1229205005533	ABC transporter signature motif; other site
1229205005534	Walker B; other site
1229205005535	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
1229205005536	D-loop; other site
1229205005537	H-loop/switch region; other site
1229205005538	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205005539	Response regulator receiver domain; Region: Response_reg; pfam00072
1229205005540	active site
1229205005541	phosphorylation site [posttranslational modification]
1229205005542	intermolecular recognition site; other site
1229205005543	dimerization interface [polypeptide binding]; other site
1229205005544	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1229205005545	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1229205005546	active site
1229205005547	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
1229205005548	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1229205005549	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1229205005550	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1229205005551	Phophatidylserine decarboxylase; Region: PSDC; pfam12588
1229205005552	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666
1229205005553	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
1229205005554	dimanganese center [ion binding]; other site
1229205005555	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
1229205005556	dimerization interface [polypeptide binding]; other site
1229205005557	metal binding site [ion binding]; metal-binding site
1229205005558	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667
1229205005559	nudix motif; other site
1229205005560	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
1229205005561	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
1229205005562	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
1229205005563	Trp docking motif [polypeptide binding]; other site
1229205005564	putative active site [active]
1229205005565	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1229205005566	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1229205005567	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1229205005568	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
1229205005569	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
1229205005570	putative molybdopterin cofactor binding site [chemical binding]; other site
1229205005571	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
1229205005572	putative molybdopterin cofactor binding site; other site
1229205005573	Hemerythrin-like domain; Region: Hr-like; cd12108
1229205005574	NAD synthetase; Reviewed; Region: nadE; PRK02628
1229205005575	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
1229205005576	multimer interface [polypeptide binding]; other site
1229205005577	active site
1229205005578	catalytic triad [active]
1229205005579	protein interface 1 [polypeptide binding]; other site
1229205005580	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1229205005581	homodimer interface [polypeptide binding]; other site
1229205005582	NAD binding pocket [chemical binding]; other site
1229205005583	ATP binding pocket [chemical binding]; other site
1229205005584	Mg binding site [ion binding]; other site
1229205005585	active-site loop [active]
1229205005586	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
1229205005587	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229205005588	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1229205005589	Coenzyme A binding pocket [chemical binding]; other site
1229205005590	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1229205005591	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1229205005592	Cytochrome c; Region: Cytochrom_C; pfam00034
1229205005593	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
1229205005594	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
1229205005595	Subunit I/III interface [polypeptide binding]; other site
1229205005596	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1229205005597	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1229205005598	D-pathway; other site
1229205005599	Putative ubiquinol binding site [chemical binding]; other site
1229205005600	Low-spin heme (heme b) binding site [chemical binding]; other site
1229205005601	Putative water exit pathway; other site
1229205005602	Binuclear center (heme o3/CuB) [ion binding]; other site
1229205005603	K-pathway; other site
1229205005604	Putative proton exit pathway; other site
1229205005605	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
1229205005606	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
1229205005607	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1229205005608	Cytochrome c; Region: Cytochrom_C; pfam00034
1229205005609	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1229205005610	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1229205005611	putative active site [active]
1229205005612	heme pocket [chemical binding]; other site
1229205005613	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1229205005614	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1229205005615	putative active site [active]
1229205005616	heme pocket [chemical binding]; other site
1229205005617	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205005618	dimer interface [polypeptide binding]; other site
1229205005619	phosphorylation site [posttranslational modification]
1229205005620	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205005621	ATP binding site [chemical binding]; other site
1229205005622	Mg2+ binding site [ion binding]; other site
1229205005623	G-X-G motif; other site
1229205005624	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1229205005625	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205005626	active site
1229205005627	phosphorylation site [posttranslational modification]
1229205005628	intermolecular recognition site; other site
1229205005629	dimerization interface [polypeptide binding]; other site
1229205005630	Response regulator receiver domain; Region: Response_reg; pfam00072
1229205005631	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205005632	active site
1229205005633	phosphorylation site [posttranslational modification]
1229205005634	intermolecular recognition site; other site
1229205005635	dimerization interface [polypeptide binding]; other site
1229205005636	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1229205005637	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1229205005638	putative dimer interface [polypeptide binding]; other site
1229205005639	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1229205005640	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1229205005641	putative dimer interface [polypeptide binding]; other site
1229205005642	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229205005643	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
1229205005644	putative ADP-binding pocket [chemical binding]; other site
1229205005645	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
1229205005646	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1229205005647	Putative ParB-like nuclease; Region: ParBc_2; cl17538
1229205005648	Low affinity iron permease; Region: Iron_permease; pfam04120
1229205005649	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
1229205005650	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1229205005651	GAF domain; Region: GAF; pfam01590
1229205005652	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1229205005653	PAS fold; Region: PAS_3; pfam08447
1229205005654	putative active site [active]
1229205005655	heme pocket [chemical binding]; other site
1229205005656	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205005657	dimer interface [polypeptide binding]; other site
1229205005658	phosphorylation site [posttranslational modification]
1229205005659	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205005660	ATP binding site [chemical binding]; other site
1229205005661	Mg2+ binding site [ion binding]; other site
1229205005662	G-X-G motif; other site
1229205005663	Response regulator receiver domain; Region: Response_reg; pfam00072
1229205005664	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205005665	active site
1229205005666	phosphorylation site [posttranslational modification]
1229205005667	intermolecular recognition site; other site
1229205005668	dimerization interface [polypeptide binding]; other site
1229205005669	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
1229205005670	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229205005671	Coenzyme A binding pocket [chemical binding]; other site
1229205005672	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1229205005673	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
1229205005674	FMN binding site [chemical binding]; other site
1229205005675	active site
1229205005676	substrate binding site [chemical binding]; other site
1229205005677	catalytic residue [active]
1229205005678	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1229205005679	putative DNA binding site [nucleotide binding]; other site
1229205005680	dimerization interface [polypeptide binding]; other site
1229205005681	putative Zn2+ binding site [ion binding]; other site
1229205005682	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
1229205005683	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205005684	PAS domain S-box; Region: sensory_box; TIGR00229
1229205005685	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1229205005686	putative active site [active]
1229205005687	heme pocket [chemical binding]; other site
1229205005688	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1229205005689	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1229205005690	hexamer interface [polypeptide binding]; other site
1229205005691	ligand binding site [chemical binding]; other site
1229205005692	putative active site [active]
1229205005693	NAD(P) binding site [chemical binding]; other site
1229205005694	RNA polymerase sigma factor; Reviewed; Region: PRK05602
1229205005695	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1229205005696	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
1229205005697	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
1229205005698	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
1229205005699	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1229205005700	Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788
1229205005701	DNA binding residues [nucleotide binding]
1229205005702	putative dimer interface [polypeptide binding]; other site
1229205005703	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
1229205005704	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
1229205005705	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205005706	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205005707	trimer interface [polypeptide binding]; other site
1229205005708	eyelet of channel; other site
1229205005709	Cupin domain; Region: Cupin_2; cl17218
1229205005710	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1229205005711	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1229205005712	catalytic residue [active]
1229205005713	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205005714	metabolite-proton symporter; Region: 2A0106; TIGR00883
1229205005715	putative substrate translocation pore; other site
1229205005716	hypothetical protein; Provisional; Region: PRK07079
1229205005717	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679
1229205005718	metal binding site [ion binding]; metal-binding site
1229205005719	putative dimer interface [polypeptide binding]; other site
1229205005720	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205005721	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205005722	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205005723	dimerization interface [polypeptide binding]; other site
1229205005724	dihydroxy-acid dehydratase; Validated; Region: PRK06131
1229205005725	hypothetical protein; Validated; Region: PRK08245
1229205005726	hypothetical protein; Validated; Region: PRK06201
1229205005727	D-galactonate transporter; Region: 2A0114; TIGR00893
1229205005728	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205005729	putative substrate translocation pore; other site
1229205005730	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1229205005731	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1229205005732	DNA binding site [nucleotide binding]
1229205005733	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
1229205005734	putative ligand binding site [chemical binding]; other site
1229205005735	putative dimerization interface [polypeptide binding]; other site
1229205005736	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
1229205005737	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1229205005738	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
1229205005739	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1229205005740	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1229205005741	D-pathway; other site
1229205005742	Putative ubiquinol binding site [chemical binding]; other site
1229205005743	Low-spin heme (heme b) binding site [chemical binding]; other site
1229205005744	Putative water exit pathway; other site
1229205005745	Binuclear center (heme o3/CuB) [ion binding]; other site
1229205005746	K-pathway; other site
1229205005747	Putative proton exit pathway; other site
1229205005748	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
1229205005749	Subunit I/III interface [polypeptide binding]; other site
1229205005750	Subunit III/IV interface [polypeptide binding]; other site
1229205005751	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
1229205005752	TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305
1229205005753	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1229205005754	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1229205005755	conserved cys residue [active]
1229205005756	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205005757	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205005758	Chain length determinant protein; Region: Wzz; pfam02706
1229205005759	tyrosine kinase; Provisional; Region: PRK11519
1229205005760	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
1229205005761	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
1229205005762	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1229205005763	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229205005764	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
1229205005765	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1229205005766	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1229205005767	active site
1229205005768	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1229205005769	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1229205005770	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229205005771	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
1229205005772	putative ADP-binding pocket [chemical binding]; other site
1229205005773	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
1229205005774	active site
1229205005775	O-Antigen ligase; Region: Wzy_C; pfam04932
1229205005776	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
1229205005777	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
1229205005778	Substrate binding site; other site
1229205005779	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
1229205005780	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
1229205005781	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1229205005782	Sugar-transfer associated ATP-grasp; Region: ATPgrasp_ST; pfam14397
1229205005783	Phasin protein; Region: Phasin_2; pfam09361
1229205005784	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1229205005785	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1229205005786	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
1229205005787	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1229205005788	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1229205005789	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
1229205005790	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1229205005791	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1229205005792	Walker A/P-loop; other site
1229205005793	ATP binding site [chemical binding]; other site
1229205005794	Q-loop/lid; other site
1229205005795	ABC transporter signature motif; other site
1229205005796	Walker B; other site
1229205005797	D-loop; other site
1229205005798	H-loop/switch region; other site
1229205005799	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
1229205005800	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1229205005801	HlyD family secretion protein; Region: HlyD_3; pfam13437
1229205005802	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229205005803	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229205005804	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
1229205005805	hypothetical protein; Provisional; Region: PRK06486
1229205005806	intersubunit interface [polypeptide binding]; other site
1229205005807	active site
1229205005808	Zn2+ binding site [ion binding]; other site
1229205005809	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
1229205005810	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229205005811	motif II; other site
1229205005812	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205005813	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205005814	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205005815	dimerization interface [polypeptide binding]; other site
1229205005816	SnoaL-like domain; Region: SnoaL_2; pfam12680
1229205005817	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1229205005818	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1229205005819	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
1229205005820	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1229205005821	Protein of unknown function (DUF330); Region: DUF330; pfam03886
1229205005822	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
1229205005823	mce related protein; Region: MCE; pfam02470
1229205005824	mce related protein; Region: MCE; pfam02470
1229205005825	mce related protein; Region: MCE; pfam02470
1229205005826	Paraquat-inducible protein A; Region: PqiA; pfam04403
1229205005827	Paraquat-inducible protein A; Region: PqiA; pfam04403
1229205005828	Protein of unknown function (DUF2950); Region: DUF2950; pfam11453
1229205005829	Protein of unknown function (DUF3300); Region: DUF3300; pfam11737
1229205005830	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1229205005831	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1229205005832	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1229205005833	active site
1229205005834	LssY C-terminus; Region: LssY_C; pfam14067
1229205005835	Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764
1229205005836	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1229205005837	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1229205005838	putative DNA binding site [nucleotide binding]; other site
1229205005839	putative Zn2+ binding site [ion binding]; other site
1229205005840	AsnC family; Region: AsnC_trans_reg; pfam01037
1229205005841	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1229205005842	hypothetical protein; Provisional; Region: PRK02237
1229205005843	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
1229205005844	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
1229205005845	peptidase domain interface [polypeptide binding]; other site
1229205005846	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
1229205005847	active site
1229205005848	catalytic triad [active]
1229205005849	calcium binding site [ion binding]; other site
1229205005850	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
1229205005851	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
1229205005852	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
1229205005853	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1229205005854	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
1229205005855	homodimer interface [polypeptide binding]; other site
1229205005856	NAD binding pocket [chemical binding]; other site
1229205005857	ATP binding pocket [chemical binding]; other site
1229205005858	Mg binding site [ion binding]; other site
1229205005859	active-site loop [active]
1229205005860	ABC1 family; Region: ABC1; cl17513
1229205005861	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
1229205005862	Amidohydrolase; Region: Amidohydro_2; pfam04909
1229205005863	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1229205005864	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205005865	putative substrate translocation pore; other site
1229205005866	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1229205005867	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1229205005868	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
1229205005869	active site
1229205005870	catalytic residues [active]
1229205005871	metal binding site [ion binding]; metal-binding site
1229205005872	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1229205005873	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1229205005874	Bacterial transcriptional regulator; Region: IclR; pfam01614
1229205005875	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
1229205005876	Protein of unknown function (DUF3460); Region: DUF3460; pfam11943
1229205005877	PAS domain S-box; Region: sensory_box; TIGR00229
1229205005878	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1229205005879	putative active site [active]
1229205005880	heme pocket [chemical binding]; other site
1229205005881	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229205005882	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205005883	dimer interface [polypeptide binding]; other site
1229205005884	phosphorylation site [posttranslational modification]
1229205005885	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205005886	ATP binding site [chemical binding]; other site
1229205005887	Mg2+ binding site [ion binding]; other site
1229205005888	G-X-G motif; other site
1229205005889	Response regulator receiver domain; Region: Response_reg; pfam00072
1229205005890	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205005891	active site
1229205005892	phosphorylation site [posttranslational modification]
1229205005893	intermolecular recognition site; other site
1229205005894	dimerization interface [polypeptide binding]; other site
1229205005895	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
1229205005896	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1229205005897	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
1229205005898	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1229205005899	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1229205005900	protein binding site [polypeptide binding]; other site
1229205005901	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1229205005902	protein binding site [polypeptide binding]; other site
1229205005903	FOG: CBS domain [General function prediction only]; Region: COG0517
1229205005904	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
1229205005905	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1229205005906	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1229205005907	classical (c) SDRs; Region: SDR_c; cd05233
1229205005908	NAD(P) binding site [chemical binding]; other site
1229205005909	active site
1229205005910	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
1229205005911	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
1229205005912	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1229205005913	catalytic residue [active]
1229205005914	BON domain; Region: BON; pfam04972
1229205005915	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
1229205005916	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
1229205005917	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
1229205005918	putative FMN binding site [chemical binding]; other site
1229205005919	NADPH bind site [chemical binding]; other site
1229205005920	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
1229205005921	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544
1229205005922	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1229205005923	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1229205005924	Cupin domain; Region: Cupin_2; pfam07883
1229205005925	OsmC-like protein; Region: OsmC; cl00767
1229205005926	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205005927	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205005928	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1229205005929	putative effector binding pocket; other site
1229205005930	dimerization interface [polypeptide binding]; other site
1229205005931	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
1229205005932	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1229205005933	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1229205005934	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1229205005935	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1229205005936	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1229205005937	Surface antigen; Region: Bac_surface_Ag; pfam01103
1229205005938	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
1229205005939	Organic solvent tolerance protein; Region: OstA_C; pfam04453
1229205005940	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1229205005941	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1229205005942	Protein of unknown function (DUF3182); Region: DUF3182; pfam11379
1229205005943	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1229205005944	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1229205005945	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1229205005946	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1229205005947	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1229205005948	2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258
1229205005949	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229205005950	Walker A/P-loop; other site
1229205005951	ATP binding site [chemical binding]; other site
1229205005952	Q-loop/lid; other site
1229205005953	ABC transporter signature motif; other site
1229205005954	Walker B; other site
1229205005955	D-loop; other site
1229205005956	H-loop/switch region; other site
1229205005957	TOBE domain; Region: TOBE_2; pfam08402
1229205005958	2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050
1229205005959	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205005960	dimer interface [polypeptide binding]; other site
1229205005961	conserved gate region; other site
1229205005962	putative PBP binding loops; other site
1229205005963	ABC-ATPase subunit interface; other site
1229205005964	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205005965	dimer interface [polypeptide binding]; other site
1229205005966	conserved gate region; other site
1229205005967	ABC-ATPase subunit interface; other site
1229205005968	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
1229205005969	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205005970	DNA-binding site [nucleotide binding]; DNA binding site
1229205005971	FCD domain; Region: FCD; pfam07729
1229205005972	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
1229205005973	Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524
1229205005974	putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250
1229205005975	Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146
1229205005976	NAD(P) binding site [chemical binding]; other site
1229205005977	catalytic residues [active]
1229205005978	phosphonate degradation operons associated HDIG domain protein; Region: Phn-HD; TIGR03276
1229205005979	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1229205005980	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1229205005981	putative active site [active]
1229205005982	putative metal binding site [ion binding]; other site
1229205005983	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
1229205005984	putative FMN binding site [chemical binding]; other site
1229205005985	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
1229205005986	Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309
1229205005987	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1229205005988	putative ligand binding site [chemical binding]; other site
1229205005989	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1229205005990	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1229205005991	Walker A/P-loop; other site
1229205005992	ATP binding site [chemical binding]; other site
1229205005993	Q-loop/lid; other site
1229205005994	ABC transporter signature motif; other site
1229205005995	Walker B; other site
1229205005996	D-loop; other site
1229205005997	H-loop/switch region; other site
1229205005998	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1229205005999	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1229205006000	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1229205006001	TM-ABC transporter signature motif; other site
1229205006002	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1229205006003	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1229205006004	TM-ABC transporter signature motif; other site
1229205006005	benzoate transport; Region: 2A0115; TIGR00895
1229205006006	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205006007	putative substrate translocation pore; other site
1229205006008	hypothetical protein; Provisional; Region: PRK05463
1229205006009	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205006010	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205006011	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1229205006012	dimerization interface [polypeptide binding]; other site
1229205006013	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1229205006014	malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131
1229205006015	phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293
1229205006016	Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620
1229205006017	malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134
1229205006018	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189
1229205006019	malonate decarboxylase subunit delta; Provisional; Region: PRK01220
1229205006020	triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237
1229205006021	malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110
1229205006022	Coenzyme A transferase; Region: CoA_trans; cl17247
1229205006023	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1229205006024	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205006025	DNA-binding site [nucleotide binding]; DNA binding site
1229205006026	FCD domain; Region: FCD; pfam07729
1229205006027	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1229205006028	EamA-like transporter family; Region: EamA; pfam00892
1229205006029	EamA-like transporter family; Region: EamA; pfam00892
1229205006030	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205006031	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205006032	dimerization interface [polypeptide binding]; other site
1229205006033	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
1229205006034	N-acetyltransferase; Region: Acetyltransf_2; pfam00797
1229205006035	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
1229205006036	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
1229205006037	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229205006038	substrate binding pocket [chemical binding]; other site
1229205006039	membrane-bound complex binding site; other site
1229205006040	hinge residues; other site
1229205006041	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1229205006042	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205006043	dimer interface [polypeptide binding]; other site
1229205006044	conserved gate region; other site
1229205006045	putative PBP binding loops; other site
1229205006046	ABC-ATPase subunit interface; other site
1229205006047	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205006048	dimer interface [polypeptide binding]; other site
1229205006049	conserved gate region; other site
1229205006050	putative PBP binding loops; other site
1229205006051	ABC-ATPase subunit interface; other site
1229205006052	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
1229205006053	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1229205006054	Walker A/P-loop; other site
1229205006055	ATP binding site [chemical binding]; other site
1229205006056	Q-loop/lid; other site
1229205006057	ABC transporter signature motif; other site
1229205006058	Walker B; other site
1229205006059	D-loop; other site
1229205006060	H-loop/switch region; other site
1229205006061	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
1229205006062	active sites [active]
1229205006063	tetramer interface [polypeptide binding]; other site
1229205006064	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
1229205006065	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205006066	DNA-binding site [nucleotide binding]; DNA binding site
1229205006067	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1229205006068	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
1229205006069	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205006070	DNA-binding site [nucleotide binding]; DNA binding site
1229205006071	UTRA domain; Region: UTRA; pfam07702
1229205006072	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1229205006073	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1229205006074	Walker A/P-loop; other site
1229205006075	ATP binding site [chemical binding]; other site
1229205006076	Q-loop/lid; other site
1229205006077	ABC transporter signature motif; other site
1229205006078	Walker B; other site
1229205006079	D-loop; other site
1229205006080	H-loop/switch region; other site
1229205006081	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205006082	dimer interface [polypeptide binding]; other site
1229205006083	conserved gate region; other site
1229205006084	putative PBP binding loops; other site
1229205006085	ABC-ATPase subunit interface; other site
1229205006086	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1229205006087	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205006088	dimer interface [polypeptide binding]; other site
1229205006089	conserved gate region; other site
1229205006090	putative PBP binding loops; other site
1229205006091	ABC-ATPase subunit interface; other site
1229205006092	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1229205006093	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229205006094	substrate binding pocket [chemical binding]; other site
1229205006095	membrane-bound complex binding site; other site
1229205006096	hinge residues; other site
1229205006097	oxidase reductase; Provisional; Region: PTZ00273
1229205006098	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
1229205006099	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
1229205006100	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1229205006101	FAD binding domain; Region: FAD_binding_4; pfam01565
1229205006102	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1229205006103	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1229205006104	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1229205006105	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229205006106	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205006107	dimer interface [polypeptide binding]; other site
1229205006108	phosphorylation site [posttranslational modification]
1229205006109	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205006110	ATP binding site [chemical binding]; other site
1229205006111	Mg2+ binding site [ion binding]; other site
1229205006112	G-X-G motif; other site
1229205006113	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1229205006114	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205006115	active site
1229205006116	phosphorylation site [posttranslational modification]
1229205006117	intermolecular recognition site; other site
1229205006118	dimerization interface [polypeptide binding]; other site
1229205006119	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1229205006120	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205006121	active site
1229205006122	phosphorylation site [posttranslational modification]
1229205006123	intermolecular recognition site; other site
1229205006124	dimerization interface [polypeptide binding]; other site
1229205006125	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1229205006126	DNA binding residues [nucleotide binding]
1229205006127	dimerization interface [polypeptide binding]; other site
1229205006128	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1229205006129	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1229205006130	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1229205006131	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1229205006132	extended (e) SDRs; Region: SDR_e; cd08946
1229205006133	NAD(P) binding site [chemical binding]; other site
1229205006134	active site
1229205006135	substrate binding site [chemical binding]; other site
1229205006136	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205006137	D-galactonate transporter; Region: 2A0114; TIGR00893
1229205006138	putative substrate translocation pore; other site
1229205006139	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
1229205006140	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
1229205006141	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
1229205006142	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1229205006143	tartronate semialdehyde reductase; Provisional; Region: PRK15059
1229205006144	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
1229205006145	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1229205006146	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
1229205006147	dimer interface [polypeptide binding]; other site
1229205006148	NADP binding site [chemical binding]; other site
1229205006149	catalytic residues [active]
1229205006150	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1229205006151	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205006152	DNA-binding site [nucleotide binding]; DNA binding site
1229205006153	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1229205006154	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205006155	D-galactonate transporter; Region: 2A0114; TIGR00893
1229205006156	putative substrate translocation pore; other site
1229205006157	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205006158	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
1229205006159	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1229205006160	putative active site [active]
1229205006161	catalytic residue [active]
1229205006162	galactarate dehydratase; Region: galactar-dH20; TIGR03248
1229205006163	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
1229205006164	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
1229205006165	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1229205006166	extended (e) SDRs; Region: SDR_e; cd08946
1229205006167	NAD(P) binding site [chemical binding]; other site
1229205006168	active site
1229205006169	substrate binding site [chemical binding]; other site
1229205006170	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1229205006171	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1229205006172	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
1229205006173	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
1229205006174	DctM-like transporters; Region: DctM; pfam06808
1229205006175	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
1229205006176	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205006177	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205006178	trimer interface [polypeptide binding]; other site
1229205006179	eyelet of channel; other site
1229205006180	aldolase II superfamily protein; Provisional; Region: PRK07044
1229205006181	intersubunit interface [polypeptide binding]; other site
1229205006182	active site
1229205006183	Zn2+ binding site [ion binding]; other site
1229205006184	Urea transporter; Region: UT; cl01829
1229205006185	Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475
1229205006186	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1229205006187	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1229205006188	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
1229205006189	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
1229205006190	short chain dehydrogenase; Provisional; Region: PRK07832
1229205006191	classical (c) SDRs; Region: SDR_c; cd05233
1229205006192	NAD(P) binding site [chemical binding]; other site
1229205006193	active site
1229205006194	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1229205006195	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1229205006196	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778
1229205006197	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1229205006198	DNA binding residues [nucleotide binding]
1229205006199	putative dimer interface [polypeptide binding]; other site
1229205006200	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1229205006201	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229205006202	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1229205006203	Coenzyme A binding pocket [chemical binding]; other site
1229205006204	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
1229205006205	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1229205006206	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205006207	DNA-binding site [nucleotide binding]; DNA binding site
1229205006208	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229205006209	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205006210	homodimer interface [polypeptide binding]; other site
1229205006211	catalytic residue [active]
1229205006212	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
1229205006213	Response regulator receiver domain; Region: Response_reg; pfam00072
1229205006214	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205006215	active site
1229205006216	phosphorylation site [posttranslational modification]
1229205006217	intermolecular recognition site; other site
1229205006218	dimerization interface [polypeptide binding]; other site
1229205006219	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1229205006220	metal binding site 2 [ion binding]; metal-binding site
1229205006221	putative DNA binding helix; other site
1229205006222	metal binding site 1 [ion binding]; metal-binding site
1229205006223	dimer interface [polypeptide binding]; other site
1229205006224	structural Zn2+ binding site [ion binding]; other site
1229205006225	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1229205006226	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
1229205006227	putative C-terminal domain interface [polypeptide binding]; other site
1229205006228	putative GSH binding site (G-site) [chemical binding]; other site
1229205006229	putative dimer interface [polypeptide binding]; other site
1229205006230	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
1229205006231	putative N-terminal domain interface [polypeptide binding]; other site
1229205006232	putative dimer interface [polypeptide binding]; other site
1229205006233	putative substrate binding pocket (H-site) [chemical binding]; other site
1229205006234	Part of AAA domain; Region: AAA_19; pfam13245
1229205006235	Family description; Region: UvrD_C_2; pfam13538
1229205006236	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1229205006237	active site
1229205006238	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1229205006239	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205006240	dimer interface [polypeptide binding]; other site
1229205006241	phosphorylation site [posttranslational modification]
1229205006242	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205006243	ATP binding site [chemical binding]; other site
1229205006244	Mg2+ binding site [ion binding]; other site
1229205006245	G-X-G motif; other site
1229205006246	Response regulator receiver domain; Region: Response_reg; pfam00072
1229205006247	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205006248	active site
1229205006249	phosphorylation site [posttranslational modification]
1229205006250	intermolecular recognition site; other site
1229205006251	dimerization interface [polypeptide binding]; other site
1229205006252	BetR domain; Region: BetR; pfam08667
1229205006253	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205006254	active site
1229205006255	phosphorylation site [posttranslational modification]
1229205006256	intermolecular recognition site; other site
1229205006257	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1229205006258	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
1229205006259	putative diguanylate cyclase; Provisional; Region: PRK13561
1229205006260	ornithine cyclodeaminase; Validated; Region: PRK07340
1229205006261	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
1229205006262	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1229205006263	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1229205006264	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1229205006265	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
1229205006266	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
1229205006267	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
1229205006268	type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352
1229205006269	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229205006270	TPR motif; other site
1229205006271	binding surface
1229205006272	Protein of unknown function (DUF770); Region: DUF770; pfam05591
1229205006273	type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355
1229205006274	Protein of unknown function (DUF877); Region: DUF877; pfam05943
1229205006275	Protein of unknown function (DUF796); Region: DUF796; pfam05638
1229205006276	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3518
1229205006277	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
1229205006278	type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359
1229205006279	type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347
1229205006280	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
1229205006281	Clp amino terminal domain; Region: Clp_N; pfam02861
1229205006282	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205006283	Walker A motif; other site
1229205006284	ATP binding site [chemical binding]; other site
1229205006285	Walker B motif; other site
1229205006286	arginine finger; other site
1229205006287	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205006288	Walker A motif; other site
1229205006289	ATP binding site [chemical binding]; other site
1229205006290	Walker B motif; other site
1229205006291	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1229205006292	type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363
1229205006293	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
1229205006294	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1229205006295	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1229205006296	ligand binding site [chemical binding]; other site
1229205006297	Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611
1229205006298	Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and    vesicular transport]; Region: IcmF; COG3523
1229205006299	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
1229205006300	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
1229205006301	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1229205006302	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
1229205006303	Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156
1229205006304	active site
1229205006305	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205006306	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205006307	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
1229205006308	putative effector binding pocket; other site
1229205006309	putative dimerization interface [polypeptide binding]; other site
1229205006310	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1229205006311	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
1229205006312	putative NAD(P) binding site [chemical binding]; other site
1229205006313	putative substrate binding site [chemical binding]; other site
1229205006314	catalytic Zn binding site [ion binding]; other site
1229205006315	structural Zn binding site [ion binding]; other site
1229205006316	dimer interface [polypeptide binding]; other site
1229205006317	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
1229205006318	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205006319	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1229205006320	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205006321	PAS domain; Region: PAS_9; pfam13426
1229205006322	PAS domain; Region: PAS_9; pfam13426
1229205006323	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1229205006324	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1229205006325	metal binding site [ion binding]; metal-binding site
1229205006326	active site
1229205006327	I-site; other site
1229205006328	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1229205006329	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
1229205006330	putative ligand binding site [chemical binding]; other site
1229205006331	NAD binding site [chemical binding]; other site
1229205006332	catalytic site [active]
1229205006333	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1229205006334	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1229205006335	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1229205006336	dimerization interface [polypeptide binding]; other site
1229205006337	PAS domain S-box; Region: sensory_box; TIGR00229
1229205006338	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1229205006339	putative active site [active]
1229205006340	heme pocket [chemical binding]; other site
1229205006341	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1229205006342	Histidine kinase; Region: HisKA_3; pfam07730
1229205006343	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205006344	ATP binding site [chemical binding]; other site
1229205006345	Mg2+ binding site [ion binding]; other site
1229205006346	G-X-G motif; other site
1229205006347	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
1229205006348	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
1229205006349	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
1229205006350	active site
1229205006351	dimer interface [polypeptide binding]; other site
1229205006352	effector binding site; other site
1229205006353	Domain of unknown function (DUF3331); Region: DUF3331; pfam11811
1229205006354	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1229205006355	Predicted esterase [General function prediction only]; Region: COG0627
1229205006356	OpgC protein; Region: OpgC_C; pfam10129
1229205006357	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205006358	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205006359	trimer interface [polypeptide binding]; other site
1229205006360	eyelet of channel; other site
1229205006361	Protein of unknown function (DUF3465); Region: DUF3465; pfam11948
1229205006362	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1229205006363	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1229205006364	Peptidase family M23; Region: Peptidase_M23; pfam01551
1229205006365	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1229205006366	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
1229205006367	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1229205006368	catalytic loop [active]
1229205006369	iron binding site [ion binding]; other site
1229205006370	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1229205006371	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1229205006372	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1229205006373	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1229205006374	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1229205006375	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1229205006376	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1229205006377	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1229205006378	Cytochrome c; Region: Cytochrom_C; pfam00034
1229205006379	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1229205006380	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205006381	dimer interface [polypeptide binding]; other site
1229205006382	conserved gate region; other site
1229205006383	putative PBP binding loops; other site
1229205006384	ABC-ATPase subunit interface; other site
1229205006385	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205006386	dimer interface [polypeptide binding]; other site
1229205006387	conserved gate region; other site
1229205006388	putative PBP binding loops; other site
1229205006389	ABC-ATPase subunit interface; other site
1229205006390	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229205006391	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1229205006392	substrate binding pocket [chemical binding]; other site
1229205006393	membrane-bound complex binding site; other site
1229205006394	hinge residues; other site
1229205006395	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1229205006396	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229205006397	Walker A/P-loop; other site
1229205006398	ATP binding site [chemical binding]; other site
1229205006399	Q-loop/lid; other site
1229205006400	ABC transporter signature motif; other site
1229205006401	Walker B; other site
1229205006402	D-loop; other site
1229205006403	H-loop/switch region; other site
1229205006404	TOBE domain; Region: TOBE_2; pfam08402
1229205006405	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1229205006406	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205006407	dimer interface [polypeptide binding]; other site
1229205006408	conserved gate region; other site
1229205006409	putative PBP binding loops; other site
1229205006410	ABC-ATPase subunit interface; other site
1229205006411	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1229205006412	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1229205006413	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205006414	putative PBP binding loops; other site
1229205006415	dimer interface [polypeptide binding]; other site
1229205006416	ABC-ATPase subunit interface; other site
1229205006417	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1229205006418	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1229205006419	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1229205006420	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205006421	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1229205006422	substrate binding pocket [chemical binding]; other site
1229205006423	dimerization interface [polypeptide binding]; other site
1229205006424	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
1229205006425	BON domain; Region: BON; pfam04972
1229205006426	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
1229205006427	active site
1229205006428	DNA binding site [nucleotide binding]
1229205006429	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
1229205006430	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
1229205006431	FOG: CBS domain [General function prediction only]; Region: COG0517
1229205006432	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1229205006433	dimerization interface [polypeptide binding]; other site
1229205006434	active site
1229205006435	haemagglutination activity domain; Region: Haemagg_act; pfam05860
1229205006436	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
1229205006437	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
1229205006438	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
1229205006439	PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616
1229205006440	haemagglutination activity domain; Region: Haemagg_act; pfam05860
1229205006441	Possible hemagglutinin (DUF637); Region: DUF637; pfam04830
1229205006442	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1229205006443	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
1229205006444	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205006445	putative substrate translocation pore; other site
1229205006446	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205006447	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205006448	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1229205006449	dimerization interface [polypeptide binding]; other site
1229205006450	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229205006451	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229205006452	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1229205006453	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1229205006454	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1229205006455	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1229205006456	HlyD family secretion protein; Region: HlyD_3; pfam13437
1229205006457	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229205006458	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229205006459	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1229205006460	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1229205006461	N-terminal domain of 2,4,5-trihydroxytoluene (THT) oxygenase; Region: THT_Oxygenase_N; cd07267
1229205006462	The C-terminal domain of 2,4,5-Trihydroxytoluene (THT) oxygenase, which is an extradiol dioxygenease in the 2,4-dinitrotoluene (DNT) degradation pathway; Region: THT_oxygenase_C; cd07257
1229205006463	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1229205006464	putative active site [active]
1229205006465	putative metal binding site [ion binding]; other site
1229205006466	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1229205006467	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1229205006468	AMP-binding domain protein; Validated; Region: PRK07529
1229205006469	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1229205006470	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944
1229205006471	acyl-activating enzyme (AAE) consensus motif; other site
1229205006472	putative AMP binding site [chemical binding]; other site
1229205006473	putative active site [active]
1229205006474	putative CoA binding site [chemical binding]; other site
1229205006475	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
1229205006476	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1229205006477	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
1229205006478	molybdopterin cofactor binding site; other site
1229205006479	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
1229205006480	molybdopterin cofactor binding site; other site
1229205006481	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
1229205006482	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
1229205006483	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
1229205006484	homotrimer interaction site [polypeptide binding]; other site
1229205006485	putative active site [active]
1229205006486	aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
1229205006487	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1229205006488	NADP binding site [chemical binding]; other site
1229205006489	putative substrate binding site [chemical binding]; other site
1229205006490	active site
1229205006491	Cupin; Region: Cupin_6; pfam12852
1229205006492	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205006493	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1229205006494	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205006495	MarR family; Region: MarR_2; cl17246
1229205006496	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1229205006497	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
1229205006498	benzoate transport; Region: 2A0115; TIGR00895
1229205006499	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205006500	putative substrate translocation pore; other site
1229205006501	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205006502	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
1229205006503	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1229205006504	catalytic loop [active]
1229205006505	iron binding site [ion binding]; other site
1229205006506	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1229205006507	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1229205006508	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1229205006509	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1229205006510	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1229205006511	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1229205006512	Predicted membrane protein [Function unknown]; Region: COG2259
1229205006513	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1229205006514	Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177
1229205006515	active site
1229205006516	dimer interface [polypeptide binding]; other site
1229205006517	metal binding site [ion binding]; metal-binding site
1229205006518	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
1229205006519	Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461
1229205006520	chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465
1229205006521	dimer interface [polypeptide binding]; other site
1229205006522	active site
1229205006523	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205006524	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205006525	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1229205006526	putative effector binding pocket; other site
1229205006527	dimerization interface [polypeptide binding]; other site
1229205006528	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205006529	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205006530	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
1229205006531	putative dimerization interface [polypeptide binding]; other site
1229205006532	putative substrate binding pocket [chemical binding]; other site
1229205006533	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205006534	metabolite-proton symporter; Region: 2A0106; TIGR00883
1229205006535	putative substrate translocation pore; other site
1229205006536	Tannase and feruloyl esterase; Region: Tannase; pfam07519
1229205006537	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1229205006538	FtsX-like permease family; Region: FtsX; pfam02687
1229205006539	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1229205006540	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1229205006541	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1229205006542	Walker A/P-loop; other site
1229205006543	ATP binding site [chemical binding]; other site
1229205006544	Q-loop/lid; other site
1229205006545	ABC transporter signature motif; other site
1229205006546	Walker B; other site
1229205006547	D-loop; other site
1229205006548	H-loop/switch region; other site
1229205006549	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1229205006550	HlyD family secretion protein; Region: HlyD_3; pfam13437
1229205006551	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205006552	NAD(P) binding site [chemical binding]; other site
1229205006553	active site
1229205006554	DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430
1229205006555	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205006556	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1229205006557	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
1229205006558	Putative zinc-finger; Region: zf-HC2; pfam13490
1229205006559	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1229205006560	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1229205006561	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1229205006562	DNA binding residues [nucleotide binding]
1229205006563	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
1229205006564	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
1229205006565	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1229205006566	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1229205006567	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
1229205006568	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
1229205006569	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1229205006570	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1229205006571	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1229205006572	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1229205006573	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
1229205006574	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1229205006575	ATP binding site [chemical binding]; other site
1229205006576	putative Mg++ binding site [ion binding]; other site
1229205006577	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1229205006578	nucleotide binding region [chemical binding]; other site
1229205006579	ATP-binding site [chemical binding]; other site
1229205006580	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1229205006581	Peptidase family M23; Region: Peptidase_M23; pfam01551
1229205006582	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
1229205006583	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
1229205006584	Helix-turn-helix domain; Region: HTH_18; pfam12833
1229205006585	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205006586	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229205006587	salt bridge; other site
1229205006588	non-specific DNA binding site [nucleotide binding]; other site
1229205006589	sequence-specific DNA binding site [nucleotide binding]; other site
1229205006590	HipA N-terminal domain; Region: Couple_hipA; pfam13657
1229205006591	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
1229205006592	HipA-like N-terminal domain; Region: HipA_N; pfam07805
1229205006593	HipA-like C-terminal domain; Region: HipA_C; pfam07804
1229205006594	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1229205006595	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205006596	DNA-binding site [nucleotide binding]; DNA binding site
1229205006597	FCD domain; Region: FCD; pfam07729
1229205006598	Amino acid synthesis; Region: AA_synth; pfam06684
1229205006599	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1229205006600	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1229205006601	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1229205006602	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1229205006603	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
1229205006604	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1229205006605	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1229205006606	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
1229205006607	NAD(P) binding site [chemical binding]; other site
1229205006608	catalytic residues [active]
1229205006609	NIPSNAP; Region: NIPSNAP; pfam07978
1229205006610	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1229205006611	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1229205006612	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205006613	dimer interface [polypeptide binding]; other site
1229205006614	conserved gate region; other site
1229205006615	putative PBP binding loops; other site
1229205006616	ABC-ATPase subunit interface; other site
1229205006617	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1229205006618	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1229205006619	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1229205006620	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
1229205006621	Walker A/P-loop; other site
1229205006622	ATP binding site [chemical binding]; other site
1229205006623	Q-loop/lid; other site
1229205006624	ABC transporter signature motif; other site
1229205006625	Walker B; other site
1229205006626	D-loop; other site
1229205006627	H-loop/switch region; other site
1229205006628	TOBE domain; Region: TOBE_2; pfam08402
1229205006629	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1229205006630	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205006631	DNA-binding site [nucleotide binding]; DNA binding site
1229205006632	FCD domain; Region: FCD; pfam07729
1229205006633	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1229205006634	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205006635	active site
1229205006636	phosphorylation site [posttranslational modification]
1229205006637	intermolecular recognition site; other site
1229205006638	dimerization interface [polypeptide binding]; other site
1229205006639	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229205006640	DNA binding site [nucleotide binding]
1229205006641	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1229205006642	FecR protein; Region: FecR; pfam04773
1229205006643	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
1229205006644	CHASE2 domain; Region: CHASE2; pfam05226
1229205006645	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229205006646	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205006647	dimer interface [polypeptide binding]; other site
1229205006648	phosphorylation site [posttranslational modification]
1229205006649	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205006650	ATP binding site [chemical binding]; other site
1229205006651	Mg2+ binding site [ion binding]; other site
1229205006652	G-X-G motif; other site
1229205006653	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
1229205006654	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
1229205006655	putative FMN binding site [chemical binding]; other site
1229205006656	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
1229205006657	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
1229205006658	catalytic triad [active]
1229205006659	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
1229205006660	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
1229205006661	homodimer interface [polypeptide binding]; other site
1229205006662	Walker A motif; other site
1229205006663	ATP binding site [chemical binding]; other site
1229205006664	hydroxycobalamin binding site [chemical binding]; other site
1229205006665	Walker B motif; other site
1229205006666	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
1229205006667	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1229205006668	active site
1229205006669	SAM binding site [chemical binding]; other site
1229205006670	homodimer interface [polypeptide binding]; other site
1229205006671	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
1229205006672	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1229205006673	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1229205006674	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
1229205006675	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
1229205006676	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
1229205006677	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
1229205006678	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205006679	Walker A motif; other site
1229205006680	ATP binding site [chemical binding]; other site
1229205006681	Walker B motif; other site
1229205006682	arginine finger; other site
1229205006683	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1229205006684	metal ion-dependent adhesion site (MIDAS); other site
1229205006685	Flagellar protein YcgR; Region: YcgR_2; pfam12945
1229205006686	PilZ domain; Region: PilZ; pfam07238
1229205006687	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
1229205006688	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1229205006689	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1229205006690	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1229205006691	FtsX-like permease family; Region: FtsX; pfam02687
1229205006692	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1229205006693	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1229205006694	Walker A/P-loop; other site
1229205006695	ATP binding site [chemical binding]; other site
1229205006696	Q-loop/lid; other site
1229205006697	ABC transporter signature motif; other site
1229205006698	Walker B; other site
1229205006699	D-loop; other site
1229205006700	H-loop/switch region; other site
1229205006701	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
1229205006702	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1229205006703	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1229205006704	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1229205006705	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1229205006706	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1229205006707	motif II; other site
1229205006708	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1229205006709	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
1229205006710	putative NAD(P) binding site [chemical binding]; other site
1229205006711	active site
1229205006712	BON domain; Region: BON; pfam04972
1229205006713	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
1229205006714	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
1229205006715	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
1229205006716	Walker A/P-loop; other site
1229205006717	ATP binding site [chemical binding]; other site
1229205006718	Q-loop/lid; other site
1229205006719	ABC transporter signature motif; other site
1229205006720	Walker B; other site
1229205006721	D-loop; other site
1229205006722	H-loop/switch region; other site
1229205006723	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1229205006724	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1229205006725	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205006726	dimer interface [polypeptide binding]; other site
1229205006727	conserved gate region; other site
1229205006728	putative PBP binding loops; other site
1229205006729	ABC-ATPase subunit interface; other site
1229205006730	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1229205006731	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
1229205006732	conserved cys residue [active]
1229205006733	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
1229205006734	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
1229205006735	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1229205006736	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
1229205006737	conserved cys residue [active]
1229205006738	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1229205006739	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205006740	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
1229205006741	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1229205006742	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1229205006743	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
1229205006744	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1229205006745	Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267
1229205006746	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
1229205006747	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
1229205006748	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1229205006749	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1229205006750	Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583
1229205006751	benzoate transport; Region: 2A0115; TIGR00895
1229205006752	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205006753	putative substrate translocation pore; other site
1229205006754	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205006755	beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289
1229205006756	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1229205006757	choline dehydrogenase; Validated; Region: PRK02106
1229205006758	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1229205006759	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
1229205006760	NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090
1229205006761	tetrameric interface [polypeptide binding]; other site
1229205006762	NAD binding site [chemical binding]; other site
1229205006763	catalytic residues [active]
1229205006764	transcriptional regulator BetI; Validated; Region: PRK00767
1229205006765	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229205006766	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1229205006767	formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819
1229205006768	Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282
1229205006769	NAD binding site [chemical binding]; other site
1229205006770	catalytic Zn binding site [ion binding]; other site
1229205006771	structural Zn binding site [ion binding]; other site
1229205006772	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1229205006773	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
1229205006774	conserved cys residue [active]
1229205006775	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205006776	serine hydroxymethyltransferase; Reviewed; Region: PRK13034
1229205006777	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1229205006778	dimer interface [polypeptide binding]; other site
1229205006779	active site
1229205006780	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1229205006781	folate binding site [chemical binding]; other site
1229205006782	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
1229205006783	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
1229205006784	active site
1229205006785	dimer interface [polypeptide binding]; other site
1229205006786	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
1229205006787	The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989
1229205006788	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
1229205006789	Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734
1229205006790	putative active site [active]
1229205006791	putative FMN binding site [chemical binding]; other site
1229205006792	putative substrate binding site [chemical binding]; other site
1229205006793	putative catalytic residue [active]
1229205006794	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1229205006795	Domain of unknown function (DUF3483); Region: DUF3483; pfam11982
1229205006796	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1229205006797	Cysteine-rich domain; Region: CCG; pfam02754
1229205006798	Cysteine-rich domain; Region: CCG; pfam02754
1229205006799	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1229205006800	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1229205006801	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
1229205006802	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1229205006803	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1229205006804	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1229205006805	[2Fe-2S] cluster binding site [ion binding]; other site
1229205006806	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
1229205006807	putative alpha subunit interface [polypeptide binding]; other site
1229205006808	putative active site [active]
1229205006809	putative substrate binding site [chemical binding]; other site
1229205006810	Fe binding site [ion binding]; other site
1229205006811	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
1229205006812	HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684
1229205006813	FAD binding pocket [chemical binding]; other site
1229205006814	FAD binding motif [chemical binding]; other site
1229205006815	phosphate binding motif [ion binding]; other site
1229205006816	beta-alpha-beta structure motif; other site
1229205006817	NAD binding pocket [chemical binding]; other site
1229205006818	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1229205006819	catalytic loop [active]
1229205006820	iron binding site [ion binding]; other site
1229205006821	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1229205006822	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
1229205006823	formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011
1229205006824	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
1229205006825	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
1229205006826	putative active site [active]
1229205006827	putative substrate binding site [chemical binding]; other site
1229205006828	putative cosubstrate binding site; other site
1229205006829	catalytic site [active]
1229205006830	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
1229205006831	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205006832	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1229205006833	dimerization interface [polypeptide binding]; other site
1229205006834	substrate binding pocket [chemical binding]; other site
1229205006835	choline-sulfatase; Region: chol_sulfatase; TIGR03417
1229205006836	Sulfatase; Region: Sulfatase; cl17466
1229205006837	Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411
1229205006838	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
1229205006839	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
1229205006840	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205006841	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205006842	trimer interface [polypeptide binding]; other site
1229205006843	eyelet of channel; other site
1229205006844	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
1229205006845	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
1229205006846	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
1229205006847	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1229205006848	NAD(P) binding site [chemical binding]; other site
1229205006849	homotetramer interface [polypeptide binding]; other site
1229205006850	homodimer interface [polypeptide binding]; other site
1229205006851	active site
1229205006852	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1229205006853	dimerization interface [polypeptide binding]; other site
1229205006854	putative DNA binding site [nucleotide binding]; other site
1229205006855	putative Zn2+ binding site [ion binding]; other site
1229205006856	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
1229205006857	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1229205006858	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1229205006859	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229205006860	motif II; other site
1229205006861	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1229205006862	CreA protein; Region: CreA; pfam05981
1229205006863	Predicted transporter component [General function prediction only]; Region: COG2391
1229205006864	Sulphur transport; Region: Sulf_transp; pfam04143
1229205006865	Predicted transporter component [General function prediction only]; Region: COG2391
1229205006866	Sulphur transport; Region: Sulf_transp; pfam04143
1229205006867	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
1229205006868	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
1229205006869	LemA family; Region: LemA; cl00742
1229205006870	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1229205006871	Ligand Binding Site [chemical binding]; other site
1229205006872	Winged helix-turn helix; Region: HTH_29; pfam13551
1229205006873	Homeodomain-like domain; Region: HTH_32; pfam13565
1229205006874	Integrase core domain; Region: rve; pfam00665
1229205006875	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1229205006876	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205006877	putative PBP binding loops; other site
1229205006878	dimer interface [polypeptide binding]; other site
1229205006879	ABC-ATPase subunit interface; other site
1229205006880	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1229205006881	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1229205006882	Walker A/P-loop; other site
1229205006883	ATP binding site [chemical binding]; other site
1229205006884	Q-loop/lid; other site
1229205006885	ABC transporter signature motif; other site
1229205006886	Walker B; other site
1229205006887	D-loop; other site
1229205006888	H-loop/switch region; other site
1229205006889	NMT1-like family; Region: NMT1_2; pfam13379
1229205006890	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1229205006891	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
1229205006892	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
1229205006893	substrate binding pocket [chemical binding]; other site
1229205006894	active site
1229205006895	iron coordination sites [ion binding]; other site
1229205006896	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1229205006897	Moco binding site; other site
1229205006898	metal coordination site [ion binding]; other site
1229205006899	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1229205006900	mobile loop; other site
1229205006901	oligomerisation interface [polypeptide binding]; other site
1229205006902	roof hairpin; other site
1229205006903	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1229205006904	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1229205006905	ring oligomerisation interface [polypeptide binding]; other site
1229205006906	ATP/Mg binding site [chemical binding]; other site
1229205006907	stacking interactions; other site
1229205006908	hinge regions; other site
1229205006909	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
1229205006910	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
1229205006911	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1229205006912	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
1229205006913	dimer interface [polypeptide binding]; other site
1229205006914	active site
1229205006915	non-prolyl cis peptide bond; other site
1229205006916	insertion regions; other site
1229205006917	hypothetical protein; Provisional; Region: PRK06208
1229205006918	intersubunit interface [polypeptide binding]; other site
1229205006919	active site
1229205006920	Zn2+ binding site [ion binding]; other site
1229205006921	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229205006922	substrate binding pocket [chemical binding]; other site
1229205006923	membrane-bound complex binding site; other site
1229205006924	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1229205006925	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1229205006926	active site
1229205006927	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1229205006928	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1229205006929	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1229205006930	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1229205006931	Walker A/P-loop; other site
1229205006932	ATP binding site [chemical binding]; other site
1229205006933	Q-loop/lid; other site
1229205006934	ABC transporter signature motif; other site
1229205006935	Walker B; other site
1229205006936	D-loop; other site
1229205006937	H-loop/switch region; other site
1229205006938	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1229205006939	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205006940	dimer interface [polypeptide binding]; other site
1229205006941	ABC-ATPase subunit interface; other site
1229205006942	putative PBP binding loops; other site
1229205006943	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1229205006944	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1229205006945	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
1229205006946	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
1229205006947	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1229205006948	putative NAD(P) binding site [chemical binding]; other site
1229205006949	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1229205006950	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229205006951	salt bridge; other site
1229205006952	non-specific DNA binding site [nucleotide binding]; other site
1229205006953	sequence-specific DNA binding site [nucleotide binding]; other site
1229205006954	YCII-related domain; Region: YCII; cl00999
1229205006955	Isochorismatase family; Region: Isochorismatase; pfam00857
1229205006956	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1229205006957	catalytic triad [active]
1229205006958	conserved cis-peptide bond; other site
1229205006959	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
1229205006960	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
1229205006961	DAK2 domain; Region: Dak2; cl03685
1229205006962	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1229205006963	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229205006964	Walker A/P-loop; other site
1229205006965	ATP binding site [chemical binding]; other site
1229205006966	Q-loop/lid; other site
1229205006967	ABC transporter signature motif; other site
1229205006968	Walker B; other site
1229205006969	D-loop; other site
1229205006970	H-loop/switch region; other site
1229205006971	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1229205006972	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229205006973	Walker A/P-loop; other site
1229205006974	ATP binding site [chemical binding]; other site
1229205006975	Q-loop/lid; other site
1229205006976	ABC transporter signature motif; other site
1229205006977	Walker B; other site
1229205006978	D-loop; other site
1229205006979	H-loop/switch region; other site
1229205006980	TOBE domain; Region: TOBE_2; pfam08402
1229205006981	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1229205006982	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205006983	dimer interface [polypeptide binding]; other site
1229205006984	conserved gate region; other site
1229205006985	putative PBP binding loops; other site
1229205006986	ABC-ATPase subunit interface; other site
1229205006987	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1229205006988	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205006989	dimer interface [polypeptide binding]; other site
1229205006990	conserved gate region; other site
1229205006991	putative PBP binding loops; other site
1229205006992	ABC-ATPase subunit interface; other site
1229205006993	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1229205006994	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1229205006995	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1229205006996	DNA binding site [nucleotide binding]
1229205006997	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
1229205006998	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1229205006999	putative ligand binding site [chemical binding]; other site
1229205007000	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205007001	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205007002	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1229205007003	putative effector binding pocket; other site
1229205007004	dimerization interface [polypeptide binding]; other site
1229205007005	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205007006	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1229205007007	transcriptional regulator; Provisional; Region: PRK10632
1229205007008	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205007009	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
1229205007010	putative effector binding pocket; other site
1229205007011	putative dimerization interface [polypeptide binding]; other site
1229205007012	SnoaL-like domain; Region: SnoaL_3; pfam13474
1229205007013	SnoaL-like domain; Region: SnoaL_2; pfam12680
1229205007014	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1229205007015	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
1229205007016	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1229205007017	HlyD family secretion protein; Region: HlyD_3; pfam13437
1229205007018	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1229205007019	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205007020	putative substrate translocation pore; other site
1229205007021	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
1229205007022	active site
1229205007023	SUMO-1 interface [polypeptide binding]; other site
1229205007024	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1229205007025	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1229205007026	conserved cys residue [active]
1229205007027	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205007028	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1229205007029	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1229205007030	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1229205007031	conserved cys residue [active]
1229205007032	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1229205007033	dimerization interface [polypeptide binding]; other site
1229205007034	putative DNA binding site [nucleotide binding]; other site
1229205007035	putative Zn2+ binding site [ion binding]; other site
1229205007036	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205007037	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229205007038	putative substrate translocation pore; other site
1229205007039	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205007040	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205007041	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205007042	dimerization interface [polypeptide binding]; other site
1229205007043	H-NS histone family; Region: Histone_HNS; pfam00816
1229205007044	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
1229205007045	Glycoside hydrolase family 71; Region: GH71; cd11577
1229205007046	putative ligand binding site [chemical binding]; other site
1229205007047	putative catalytic site [active]
1229205007048	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1229205007049	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229205007050	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
1229205007051	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
1229205007052	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229205007053	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1229205007054	exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005
1229205007055	Chain length determinant protein; Region: Wzz; pfam02706
1229205007056	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
1229205007057	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1229205007058	P loop; other site
1229205007059	Nucleotide binding site [chemical binding]; other site
1229205007060	DTAP/Switch II; other site
1229205007061	Switch I; other site
1229205007062	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1229205007063	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
1229205007064	active site
1229205007065	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
1229205007066	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
1229205007067	SLBB domain; Region: SLBB; pfam10531
1229205007068	SLBB domain; Region: SLBB; pfam10531
1229205007069	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
1229205007070	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1229205007071	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1229205007072	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1229205007073	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1229205007074	conserved cys residue [active]
1229205007075	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205007076	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205007077	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1229205007078	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1229205007079	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205007080	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205007081	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
1229205007082	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1229205007083	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1229205007084	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_2; cd07580
1229205007085	putative active site [active]
1229205007086	catalytic triad [active]
1229205007087	putative dimer interface [polypeptide binding]; other site
1229205007088	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1229205007089	Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358
1229205007090	putative ligand binding site [chemical binding]; other site
1229205007091	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1229205007092	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1229205007093	TM-ABC transporter signature motif; other site
1229205007094	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1229205007095	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1229205007096	TM-ABC transporter signature motif; other site
1229205007097	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1229205007098	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1229205007099	Walker A/P-loop; other site
1229205007100	ATP binding site [chemical binding]; other site
1229205007101	Q-loop/lid; other site
1229205007102	ABC transporter signature motif; other site
1229205007103	Walker B; other site
1229205007104	D-loop; other site
1229205007105	H-loop/switch region; other site
1229205007106	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1229205007107	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1229205007108	Walker A/P-loop; other site
1229205007109	ATP binding site [chemical binding]; other site
1229205007110	Q-loop/lid; other site
1229205007111	ABC transporter signature motif; other site
1229205007112	Walker B; other site
1229205007113	D-loop; other site
1229205007114	H-loop/switch region; other site
1229205007115	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1229205007116	Amidase; Region: Amidase; cl11426
1229205007117	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1229205007118	Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357
1229205007119	ligand binding site [chemical binding]; other site
1229205007120	regulator interaction site; other site
1229205007121	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
1229205007122	ANTAR domain; Region: ANTAR; pfam03861
1229205007123	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1229205007124	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1229205007125	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229205007126	DNA binding site [nucleotide binding]
1229205007127	Bacterial type III secretion protein (HrpB1_HrpK); Region: HrpB1_HrpK; pfam09613
1229205007128	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1229205007129	Cytochrome P450; Region: p450; cl12078
1229205007130	Protein of unknown function (DUF3455); Region: DUF3455; pfam11937
1229205007131	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1229205007132	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1229205007133	iron-sulfur cluster [ion binding]; other site
1229205007134	[2Fe-2S] cluster binding site [ion binding]; other site
1229205007135	C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
1229205007136	alpha subunit interface [polypeptide binding]; other site
1229205007137	active site
1229205007138	substrate binding site [chemical binding]; other site
1229205007139	Fe binding site [ion binding]; other site
1229205007140	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1229205007141	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205007142	active site
1229205007143	phosphorylation site [posttranslational modification]
1229205007144	dimerization interface [polypeptide binding]; other site
1229205007145	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229205007146	DNA binding site [nucleotide binding]
1229205007147	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1229205007148	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
1229205007149	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1229205007150	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
1229205007151	type III secretion system ATPase; Provisional; Region: PRK09099
1229205007152	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1229205007153	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1229205007154	Walker A motif; other site
1229205007155	ATP binding site [chemical binding]; other site
1229205007156	Walker B motif; other site
1229205007157	type III secretion system protein HrpB; Validated; Region: PRK09098
1229205007158	Flagellar assembly protein FliH; Region: FliH; pfam02108
1229205007159	type III secretion apparatus lipoprotein, YscJ/HrcJ family; Region: III_secr_YscJ; TIGR02544
1229205007160	Bacterial type III secretion protein (HrpB2); Region: HrpB2; cl09721
1229205007161	type III secretion protein HrpB1/HrpK; Region: HrpB1_HrpK; TIGR02561
1229205007162	type III secretion system protein HrcU; Validated; Region: PRK09108
1229205007163	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
1229205007164	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
1229205007165	FHIPEP family; Region: FHIPEP; pfam00771
1229205007166	Type III secretion protein (HpaP); Region: HpaP; cl17849
1229205007167	type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551
1229205007168	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
1229205007169	type III secretion system protein YscR; Provisional; Region: PRK12797
1229205007170	Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794
1229205007171	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1229205007172	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1229205007173	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1229205007174	substrate binding pocket [chemical binding]; other site
1229205007175	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1229205007176	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1229205007177	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1229205007178	catalytic residue [active]
1229205007179	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1229205007180	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229205007181	substrate binding pocket [chemical binding]; other site
1229205007182	membrane-bound complex binding site; other site
1229205007183	hinge residues; other site
1229205007184	56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694
1229205007185	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
1229205007186	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
1229205007187	Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140
1229205007188	putative active site [active]
1229205007189	catalytic site [active]
1229205007190	Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143
1229205007191	putative active site [active]
1229205007192	catalytic site [active]
1229205007193	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1229205007194	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1229205007195	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1229205007196	putative catalytic site [active]
1229205007197	putative metal binding site [ion binding]; other site
1229205007198	putative phosphate binding site [ion binding]; other site
1229205007199	Ribonuclease P; Region: Ribonuclease_P; cl00457
1229205007200	DnaA N-terminal domain; Region: DnaA_N; pfam11638
1229205007201	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
1229205007202	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205007203	Walker A motif; other site
1229205007204	ATP binding site [chemical binding]; other site
1229205007205	Walker B motif; other site
1229205007206	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1229205007207	arginine finger; other site
1229205007208	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1229205007209	DnaA box-binding interface [nucleotide binding]; other site
1229205007210	DNA polymerase III subunit beta; Validated; Region: PRK05643
1229205007211	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1229205007212	putative DNA binding surface [nucleotide binding]; other site
1229205007213	dimer interface [polypeptide binding]; other site
1229205007214	beta-clamp/clamp loader binding surface; other site
1229205007215	beta-clamp/translesion DNA polymerase binding surface; other site
1229205007216	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
1229205007217	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205007218	ATP binding site [chemical binding]; other site
1229205007219	Mg2+ binding site [ion binding]; other site
1229205007220	G-X-G motif; other site
1229205007221	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1229205007222	anchoring element; other site
1229205007223	dimer interface [polypeptide binding]; other site
1229205007224	ATP binding site [chemical binding]; other site
1229205007225	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1229205007226	active site
1229205007227	putative metal-binding site [ion binding]; other site
1229205007228	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1229205007229	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
1229205007230	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
1229205007231	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
1229205007232	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
1229205007233	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
1229205007234	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
1229205007235	PAAR motif; Region: PAAR_motif; pfam05488
1229205007236	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1229205007237	Transposase; Region: HTH_Tnp_1; pfam01527
1229205007238	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1229205007239	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1229205007240	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
1229205007241	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1229205007242	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
1229205007243	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1229205007244	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1229205007245	TIGR02594 family protein; Region: TIGR02594
1229205007246	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1229205007247	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205007248	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
1229205007249	ethanolamine permease; Region: 2A0305; TIGR00908
1229205007250	hypothetical protein; Provisional; Region: PHA02764
1229205007251	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
1229205007252	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
1229205007253	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
1229205007254	Protein of unknown function (DUF779); Region: DUF779; pfam05610
1229205007255	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
1229205007256	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1229205007257	NAD(P) binding site [chemical binding]; other site
1229205007258	catalytic residues [active]
1229205007259	Helix-turn-helix domain; Region: HTH_18; pfam12833
1229205007260	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205007261	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1229205007262	Heavy-metal-associated domain; Region: HMA; pfam00403
1229205007263	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1229205007264	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1229205007265	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
1229205007266	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
1229205007267	DNA binding residues [nucleotide binding]
1229205007268	dimer interface [polypeptide binding]; other site
1229205007269	putative metal binding site [ion binding]; other site
1229205007270	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
1229205007271	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1229205007272	ATP binding site [chemical binding]; other site
1229205007273	Mg++ binding site [ion binding]; other site
1229205007274	motif III; other site
1229205007275	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1229205007276	nucleotide binding region [chemical binding]; other site
1229205007277	ATP-binding site [chemical binding]; other site
1229205007278	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
1229205007279	putative RNA binding site [nucleotide binding]; other site
1229205007280	putative aminotransferase; Provisional; Region: PRK12414
1229205007281	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229205007282	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205007283	homodimer interface [polypeptide binding]; other site
1229205007284	catalytic residue [active]
1229205007285	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1229205007286	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229205007287	substrate binding pocket [chemical binding]; other site
1229205007288	membrane-bound complex binding site; other site
1229205007289	hinge residues; other site
1229205007290	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1229205007291	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1229205007292	active site residue [active]
1229205007293	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1229205007294	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
1229205007295	dimer interface [polypeptide binding]; other site
1229205007296	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1229205007297	catalytic triad [active]
1229205007298	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
1229205007299	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
1229205007300	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1229205007301	N-terminal plug; other site
1229205007302	ligand-binding site [chemical binding]; other site
1229205007303	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1229205007304	CoenzymeA binding site [chemical binding]; other site
1229205007305	subunit interaction site [polypeptide binding]; other site
1229205007306	PHB binding site; other site
1229205007307	Patatin-like phospholipase; Region: Patatin; pfam01734
1229205007308	active site
1229205007309	nucleophile elbow; other site
1229205007310	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
1229205007311	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1229205007312	dimerization interface [polypeptide binding]; other site
1229205007313	NAD binding site [chemical binding]; other site
1229205007314	ligand binding site [chemical binding]; other site
1229205007315	catalytic site [active]
1229205007316	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
1229205007317	active site
1229205007318	substrate-binding site [chemical binding]; other site
1229205007319	metal-binding site [ion binding]
1229205007320	GTP binding site [chemical binding]; other site
1229205007321	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205007322	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205007323	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1229205007324	putative effector binding pocket; other site
1229205007325	dimerization interface [polypeptide binding]; other site
1229205007326	DNA topoisomerase III; Validated; Region: PRK08173
1229205007327	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1229205007328	active site
1229205007329	putative interdomain interaction site [polypeptide binding]; other site
1229205007330	putative metal-binding site [ion binding]; other site
1229205007331	putative nucleotide binding site [chemical binding]; other site
1229205007332	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1229205007333	domain I; other site
1229205007334	DNA binding groove [nucleotide binding]
1229205007335	phosphate binding site [ion binding]; other site
1229205007336	domain II; other site
1229205007337	domain III; other site
1229205007338	nucleotide binding site [chemical binding]; other site
1229205007339	catalytic site [active]
1229205007340	domain IV; other site
1229205007341	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
1229205007342	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
1229205007343	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1229205007344	catalytic residues [active]
1229205007345	DNA protecting protein DprA; Region: dprA; TIGR00732
1229205007346	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
1229205007347	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1229205007348	active site
1229205007349	catalytic residues [active]
1229205007350	metal binding site [ion binding]; metal-binding site
1229205007351	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1229205007352	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1229205007353	putative active site [active]
1229205007354	substrate binding site [chemical binding]; other site
1229205007355	putative cosubstrate binding site; other site
1229205007356	catalytic site [active]
1229205007357	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1229205007358	substrate binding site [chemical binding]; other site
1229205007359	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1229205007360	M48 family peptidase; Provisional; Region: PRK03001
1229205007361	16S rRNA methyltransferase B; Provisional; Region: PRK10901
1229205007362	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
1229205007363	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229205007364	S-adenosylmethionine binding site [chemical binding]; other site
1229205007365	Domain of unknown function (DUF4390); Region: DUF4390; pfam14334
1229205007366	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
1229205007367	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1229205007368	dimerization interface [polypeptide binding]; other site
1229205007369	PAS domain; Region: PAS; smart00091
1229205007370	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205007371	dimer interface [polypeptide binding]; other site
1229205007372	phosphorylation site [posttranslational modification]
1229205007373	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205007374	ATP binding site [chemical binding]; other site
1229205007375	Mg2+ binding site [ion binding]; other site
1229205007376	G-X-G motif; other site
1229205007377	Response regulator receiver domain; Region: Response_reg; pfam00072
1229205007378	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205007379	active site
1229205007380	phosphorylation site [posttranslational modification]
1229205007381	intermolecular recognition site; other site
1229205007382	dimerization interface [polypeptide binding]; other site
1229205007383	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
1229205007384	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
1229205007385	Ligand Binding Site [chemical binding]; other site
1229205007386	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
1229205007387	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
1229205007388	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
1229205007389	active site
1229205007390	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
1229205007391	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1229205007392	Sel1-like repeats; Region: SEL1; smart00671
1229205007393	Sel1-like repeats; Region: SEL1; smart00671
1229205007394	Sel1-like repeats; Region: SEL1; smart00671
1229205007395	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
1229205007396	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
1229205007397	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1229205007398	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1229205007399	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
1229205007400	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792
1229205007401	rod shape-determining protein MreC; Region: MreC; pfam04085
1229205007402	rod shape-determining protein MreB; Provisional; Region: PRK13927
1229205007403	MreB and similar proteins; Region: MreB_like; cd10225
1229205007404	nucleotide binding site [chemical binding]; other site
1229205007405	Mg binding site [ion binding]; other site
1229205007406	putative protofilament interaction site [polypeptide binding]; other site
1229205007407	RodZ interaction site [polypeptide binding]; other site
1229205007408	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1229205007409	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1229205007410	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1229205007411	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1229205007412	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1229205007413	GatB domain; Region: GatB_Yqey; smart00845
1229205007414	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
1229205007415	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
1229205007416	putative active site [active]
1229205007417	putative catalytic site [active]
1229205007418	putative DNA binding site [nucleotide binding]; other site
1229205007419	putative phosphate binding site [ion binding]; other site
1229205007420	metal binding site A [ion binding]; metal-binding site
1229205007421	putative AP binding site [nucleotide binding]; other site
1229205007422	putative metal binding site B [ion binding]; other site
1229205007423	Peptidase family M48; Region: Peptidase_M48; cl12018
1229205007424	Acetyl-coenzyme A transporter 1; Region: Acatn; pfam13000
1229205007425	muropeptide transporter; Reviewed; Region: ampG; PRK11902
1229205007426	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205007427	putative substrate translocation pore; other site
1229205007428	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1229205007429	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
1229205007430	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
1229205007431	division inhibitor protein; Provisional; Region: slmA; PRK09480
1229205007432	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229205007433	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
1229205007434	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229205007435	motif II; other site
1229205007436	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
1229205007437	feedback inhibition sensing region; other site
1229205007438	homohexameric interface [polypeptide binding]; other site
1229205007439	nucleotide binding site [chemical binding]; other site
1229205007440	N-acetyl-L-glutamate binding site [chemical binding]; other site
1229205007441	type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552
1229205007442	TPR repeat; Region: TPR_11; pfam13414
1229205007443	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229205007444	binding surface
1229205007445	TPR motif; other site
1229205007446	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1229205007447	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1229205007448	binding surface
1229205007449	TPR motif; other site
1229205007450	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229205007451	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1229205007452	dimer interface [polypeptide binding]; other site
1229205007453	phosphorylation site [posttranslational modification]
1229205007454	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205007455	ATP binding site [chemical binding]; other site
1229205007456	Mg2+ binding site [ion binding]; other site
1229205007457	G-X-G motif; other site
1229205007458	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
1229205007459	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205007460	active site
1229205007461	phosphorylation site [posttranslational modification]
1229205007462	intermolecular recognition site; other site
1229205007463	dimerization interface [polypeptide binding]; other site
1229205007464	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1229205007465	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
1229205007466	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205007467	Walker A motif; other site
1229205007468	ATP binding site [chemical binding]; other site
1229205007469	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205007470	Walker B motif; other site
1229205007471	arginine finger; other site
1229205007472	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1229205007473	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
1229205007474	active site
1229205007475	HslU subunit interaction site [polypeptide binding]; other site
1229205007476	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
1229205007477	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1229205007478	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
1229205007479	P-loop, Walker A motif; other site
1229205007480	Base recognition motif; other site
1229205007481	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1229205007482	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
1229205007483	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
1229205007484	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
1229205007485	putative RNA binding site [nucleotide binding]; other site
1229205007486	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229205007487	S-adenosylmethionine binding site [chemical binding]; other site
1229205007488	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
1229205007489	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1229205007490	active site
1229205007491	DNA binding site [nucleotide binding]
1229205007492	Int/Topo IB signature motif; other site
1229205007493	Protein of unknown function, DUF484; Region: DUF484; cl17449
1229205007494	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
1229205007495	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1229205007496	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1229205007497	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1229205007498	putative acyl-acceptor binding pocket; other site
1229205007499	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1229205007500	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1229205007501	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1229205007502	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1229205007503	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
1229205007504	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1229205007505	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1229205007506	active site
1229205007507	catalytic tetrad [active]
1229205007508	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1229205007509	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205007510	putative substrate translocation pore; other site
1229205007511	serine/threonine protein kinase; Provisional; Region: PRK11768
1229205007512	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
1229205007513	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
1229205007514	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
1229205007515	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1229205007516	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1229205007517	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
1229205007518	putative hydrophobic ligand binding site [chemical binding]; other site
1229205007519	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
1229205007520	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1229205007521	metal ion-dependent adhesion site (MIDAS); other site
1229205007522	MoxR-like ATPases [General function prediction only]; Region: COG0714
1229205007523	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205007524	Walker A motif; other site
1229205007525	ATP binding site [chemical binding]; other site
1229205007526	Walker B motif; other site
1229205007527	arginine finger; other site
1229205007528	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
1229205007529	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
1229205007530	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1229205007531	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1229205007532	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1229205007533	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
1229205007534	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
1229205007535	catalytic loop [active]
1229205007536	iron binding site [ion binding]; other site
1229205007537	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1229205007538	amino acid transporter; Region: 2A0306; TIGR00909
1229205007539	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1229205007540	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1229205007541	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205007542	active site
1229205007543	phosphorylation site [posttranslational modification]
1229205007544	intermolecular recognition site; other site
1229205007545	dimerization interface [polypeptide binding]; other site
1229205007546	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1229205007547	DNA binding residues [nucleotide binding]
1229205007548	dimerization interface [polypeptide binding]; other site
1229205007549	Histidine kinase; Region: HisKA_3; pfam07730
1229205007550	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205007551	ATP binding site [chemical binding]; other site
1229205007552	Mg2+ binding site [ion binding]; other site
1229205007553	G-X-G motif; other site
1229205007554	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1229205007555	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
1229205007556	FAD binding pocket [chemical binding]; other site
1229205007557	FAD binding motif [chemical binding]; other site
1229205007558	phosphate binding motif [ion binding]; other site
1229205007559	beta-alpha-beta structure motif; other site
1229205007560	NAD binding pocket [chemical binding]; other site
1229205007561	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1229205007562	putative catalytic site [active]
1229205007563	putative phosphate binding site [ion binding]; other site
1229205007564	putative metal binding site [ion binding]; other site
1229205007565	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205007566	Walker A motif; other site
1229205007567	ATP binding site [chemical binding]; other site
1229205007568	Walker B motif; other site
1229205007569	arginine finger; other site
1229205007570	Predicted dehydrogenase [General function prediction only]; Region: COG0579
1229205007571	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1229205007572	High potential iron-sulfur protein; Region: HIPIP; pfam01355
1229205007573	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1229205007574	Amidase; Region: Amidase; cl11426
1229205007575	Dienelactone hydrolase family; Region: DLH; pfam01738
1229205007576	Nitronate monooxygenase; Region: NMO; pfam03060
1229205007577	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1229205007578	FMN binding site [chemical binding]; other site
1229205007579	substrate binding site [chemical binding]; other site
1229205007580	putative catalytic residue [active]
1229205007581	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1229205007582	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1229205007583	dimerization interface [polypeptide binding]; other site
1229205007584	ligand binding site [chemical binding]; other site
1229205007585	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
1229205007586	H-NS histone family; Region: Histone_HNS; pfam00816
1229205007587	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
1229205007588	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1229205007589	Cation efflux family; Region: Cation_efflux; pfam01545
1229205007590	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1229205007591	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1229205007592	putative DNA binding site [nucleotide binding]; other site
1229205007593	putative Zn2+ binding site [ion binding]; other site
1229205007594	AsnC family; Region: AsnC_trans_reg; pfam01037
1229205007595	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
1229205007596	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1229205007597	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
1229205007598	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
1229205007599	Predicted methyltransferases [General function prediction only]; Region: COG0313
1229205007600	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1229205007601	putative SAM binding site [chemical binding]; other site
1229205007602	putative homodimer interface [polypeptide binding]; other site
1229205007603	hypothetical protein; Provisional; Region: PRK14673
1229205007604	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
1229205007605	dimer interface [polypeptide binding]; other site
1229205007606	active site
1229205007607	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
1229205007608	BON domain; Region: BON; pfam04972
1229205007609	BON domain; Region: BON; pfam04972
1229205007610	Cytochrome c; Region: Cytochrom_C; cl11414
1229205007611	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
1229205007612	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
1229205007613	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
1229205007614	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
1229205007615	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253
1229205007616	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1229205007617	Protein of unknown function (DUF3274); Region: DUF3274; pfam11678
1229205007618	Protein of unknown function (DUF2875); Region: DUF2875; pfam11394
1229205007619	PAAR motif; Region: PAAR_motif; pfam05488
1229205007620	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1229205007621	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1229205007622	metal binding site [ion binding]; metal-binding site
1229205007623	active site
1229205007624	I-site; other site
1229205007625	Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998
1229205007626	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
1229205007627	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
1229205007628	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1229205007629	CutC family; Region: CutC; cl01218
1229205007630	2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13030
1229205007631	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1229205007632	dimer interface [polypeptide binding]; other site
1229205007633	PYR/PP interface [polypeptide binding]; other site
1229205007634	TPP binding site [chemical binding]; other site
1229205007635	substrate binding site [chemical binding]; other site
1229205007636	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1229205007637	TPP-binding site [chemical binding]; other site
1229205007638	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
1229205007639	Inward rectifier potassium channel; Region: IRK; pfam01007
1229205007640	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
1229205007641	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1229205007642	putative substrate binding site [chemical binding]; other site
1229205007643	putative ATP binding site [chemical binding]; other site
1229205007644	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
1229205007645	dimerization interface [polypeptide binding]; other site
1229205007646	putative active cleft [active]
1229205007647	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1229205007648	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1229205007649	DNA binding site [nucleotide binding]
1229205007650	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1229205007651	ligand binding site [chemical binding]; other site
1229205007652	dimerization interface [polypeptide binding]; other site
1229205007653	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1229205007654	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598
1229205007655	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1229205007656	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1229205007657	metal binding site [ion binding]; metal-binding site
1229205007658	active site
1229205007659	I-site; other site
1229205007660	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1229205007661	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
1229205007662	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205007663	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205007664	eyelet of channel; other site
1229205007665	trimer interface [polypeptide binding]; other site
1229205007666	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205007667	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205007668	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1229205007669	putative effector binding pocket; other site
1229205007670	dimerization interface [polypeptide binding]; other site
1229205007671	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
1229205007672	B12 binding site [chemical binding]; other site
1229205007673	cobalt ligand [ion binding]; other site
1229205007674	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
1229205007675	Walker A; other site
1229205007676	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
1229205007677	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
1229205007678	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1229205007679	FMN binding site [chemical binding]; other site
1229205007680	substrate binding site [chemical binding]; other site
1229205007681	putative catalytic residue [active]
1229205007682	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
1229205007683	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1229205007684	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1229205007685	putative DNA binding site [nucleotide binding]; other site
1229205007686	putative Zn2+ binding site [ion binding]; other site
1229205007687	AsnC family; Region: AsnC_trans_reg; pfam01037
1229205007688	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1229205007689	EamA-like transporter family; Region: EamA; pfam00892
1229205007690	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1229205007691	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
1229205007692	active site
1229205007693	catalytic site [active]
1229205007694	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
1229205007695	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
1229205007696	putative deacylase active site [active]
1229205007697	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
1229205007698	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
1229205007699	active site
1229205007700	catalytic residues [active]
1229205007701	metal binding site [ion binding]; metal-binding site
1229205007702	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1229205007703	Serine hydrolase; Region: Ser_hydrolase; pfam06821
1229205007704	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1229205007705	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
1229205007706	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1229205007707	biotin synthase; Region: bioB; TIGR00433
1229205007708	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1229205007709	FeS/SAM binding site; other site
1229205007710	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
1229205007711	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
1229205007712	AAA domain; Region: AAA_26; pfam13500
1229205007713	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
1229205007714	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1229205007715	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1229205007716	catalytic residue [active]
1229205007717	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06943
1229205007718	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1229205007719	inhibitor-cofactor binding pocket; inhibition site
1229205007720	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205007721	catalytic residue [active]
1229205007722	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1229205007723	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1229205007724	hypothetical protein; Provisional; Region: PRK01842
1229205007725	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1229205007726	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1229205007727	active site
1229205007728	C factor cell-cell signaling protein; Provisional; Region: PRK09009
1229205007729	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
1229205007730	NADP binding site [chemical binding]; other site
1229205007731	homodimer interface [polypeptide binding]; other site
1229205007732	active site
1229205007733	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
1229205007734	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1229205007735	dimer interface [polypeptide binding]; other site
1229205007736	active site
1229205007737	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
1229205007738	active site clefts [active]
1229205007739	zinc binding site [ion binding]; other site
1229205007740	dimer interface [polypeptide binding]; other site
1229205007741	bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946
1229205007742	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
1229205007743	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
1229205007744	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1229205007745	DNA binding residues [nucleotide binding]
1229205007746	putative dimer interface [polypeptide binding]; other site
1229205007747	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1229205007748	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1229205007749	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
1229205007750	peptide binding site [polypeptide binding]; other site
1229205007751	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1229205007752	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1229205007753	intersubunit interface [polypeptide binding]; other site
1229205007754	short chain dehydrogenase; Provisional; Region: PRK07024
1229205007755	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205007756	NAD(P) binding site [chemical binding]; other site
1229205007757	active site
1229205007758	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
1229205007759	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1229205007760	catalytic residues [active]
1229205007761	hinge region; other site
1229205007762	alpha helical domain; other site
1229205007763	Sporulation related domain; Region: SPOR; pfam05036
1229205007764	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
1229205007765	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1229205007766	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1229205007767	active site
1229205007768	HIGH motif; other site
1229205007769	KMSK motif region; other site
1229205007770	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
1229205007771	tRNA binding surface [nucleotide binding]; other site
1229205007772	anticodon binding site; other site
1229205007773	Domain of unknown function (DUF1840); Region: DUF1840; pfam08895
1229205007774	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
1229205007775	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
1229205007776	substrate binding pocket [chemical binding]; other site
1229205007777	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
1229205007778	B12 binding site [chemical binding]; other site
1229205007779	cobalt ligand [ion binding]; other site
1229205007780	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
1229205007781	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
1229205007782	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
1229205007783	Protein of unknown function (DUF3567); Region: DUF3567; pfam12091
1229205007784	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
1229205007785	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1229205007786	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
1229205007787	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1229205007788	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1229205007789	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1229205007790	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1229205007791	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1229205007792	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
1229205007793	putative ligand binding site [chemical binding]; other site
1229205007794	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1229205007795	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1229205007796	substrate binding site [chemical binding]; other site
1229205007797	oxyanion hole (OAH) forming residues; other site
1229205007798	trimer interface [polypeptide binding]; other site
1229205007799	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
1229205007800	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
1229205007801	dinuclear metal binding motif [ion binding]; other site
1229205007802	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
1229205007803	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
1229205007804	active site
1229205007805	HIGH motif; other site
1229205007806	nucleotide binding site [chemical binding]; other site
1229205007807	pantothenate kinase; Reviewed; Region: PRK13328
1229205007808	biotin--protein ligase; Provisional; Region: PRK06955
1229205007809	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
1229205007810	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
1229205007811	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1229205007812	Permease; Region: Permease; pfam02405
1229205007813	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
1229205007814	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
1229205007815	Walker A/P-loop; other site
1229205007816	ATP binding site [chemical binding]; other site
1229205007817	Q-loop/lid; other site
1229205007818	ABC transporter signature motif; other site
1229205007819	Walker B; other site
1229205007820	D-loop; other site
1229205007821	H-loop/switch region; other site
1229205007822	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
1229205007823	mce related protein; Region: MCE; pfam02470
1229205007824	Protein of unknown function (DUF330); Region: DUF330; pfam03886
1229205007825	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
1229205007826	dimer interface [polypeptide binding]; other site
1229205007827	[2Fe-2S] cluster binding site [ion binding]; other site
1229205007828	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
1229205007829	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1229205007830	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1229205007831	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
1229205007832	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1229205007833	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
1229205007834	homodimer interface [polypeptide binding]; other site
1229205007835	substrate-cofactor binding pocket; other site
1229205007836	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205007837	catalytic residue [active]
1229205007838	Protein of unknown function (DUF493); Region: DUF493; cl01102
1229205007839	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1229205007840	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205007841	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1229205007842	dimerization interface [polypeptide binding]; other site
1229205007843	substrate binding pocket [chemical binding]; other site
1229205007844	Protein of unknown function (DUF2917); Region: DUF2917; pfam11142
1229205007845	lipoate-protein ligase B; Provisional; Region: PRK14343
1229205007846	lipoyl synthase; Provisional; Region: PRK05481
1229205007847	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1229205007848	FeS/SAM binding site; other site
1229205007849	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1229205007850	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1229205007851	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
1229205007852	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1229205007853	PhoU domain; Region: PhoU; pfam01895
1229205007854	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1229205007855	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1229205007856	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1229205007857	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
1229205007858	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
1229205007859	putative active site [active]
1229205007860	catalytic site [active]
1229205007861	putative metal binding site [ion binding]; other site
1229205007862	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1229205007863	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1229205007864	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1229205007865	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205007866	putative PBP binding loops; other site
1229205007867	dimer interface [polypeptide binding]; other site
1229205007868	ABC-ATPase subunit interface; other site
1229205007869	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1229205007870	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1229205007871	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205007872	dimer interface [polypeptide binding]; other site
1229205007873	ABC-ATPase subunit interface; other site
1229205007874	putative PBP binding loops; other site
1229205007875	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1229205007876	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229205007877	Walker A/P-loop; other site
1229205007878	ATP binding site [chemical binding]; other site
1229205007879	Q-loop/lid; other site
1229205007880	ABC transporter signature motif; other site
1229205007881	Walker B; other site
1229205007882	D-loop; other site
1229205007883	H-loop/switch region; other site
1229205007884	TOBE domain; Region: TOBE_2; pfam08402
1229205007885	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
1229205007886	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1229205007887	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
1229205007888	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205007889	dimer interface [polypeptide binding]; other site
1229205007890	phosphorylation site [posttranslational modification]
1229205007891	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205007892	ATP binding site [chemical binding]; other site
1229205007893	Mg2+ binding site [ion binding]; other site
1229205007894	G-X-G motif; other site
1229205007895	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1229205007896	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205007897	active site
1229205007898	phosphorylation site [posttranslational modification]
1229205007899	intermolecular recognition site; other site
1229205007900	dimerization interface [polypeptide binding]; other site
1229205007901	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205007902	Walker A motif; other site
1229205007903	ATP binding site [chemical binding]; other site
1229205007904	Walker B motif; other site
1229205007905	arginine finger; other site
1229205007906	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1229205007907	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1229205007908	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1229205007909	catalytic residues [active]
1229205007910	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
1229205007911	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1229205007912	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205007913	Walker A motif; other site
1229205007914	ATP binding site [chemical binding]; other site
1229205007915	Walker B motif; other site
1229205007916	arginine finger; other site
1229205007917	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
1229205007918	Membrane fusogenic activity; Region: BMFP; pfam04380
1229205007919	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
1229205007920	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1229205007921	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1229205007922	glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049
1229205007923	Glutamate-cysteine ligase; Region: GshA; pfam08886
1229205007924	glutathione synthetase; Provisional; Region: PRK05246
1229205007925	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
1229205007926	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
1229205007927	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1229205007928	active pocket/dimerization site; other site
1229205007929	active site
1229205007930	phosphorylation site [posttranslational modification]
1229205007931	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1229205007932	dimerization domain swap beta strand [polypeptide binding]; other site
1229205007933	regulatory protein interface [polypeptide binding]; other site
1229205007934	active site
1229205007935	regulatory phosphorylation site [posttranslational modification]; other site
1229205007936	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1229205007937	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1229205007938	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1229205007939	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1229205007940	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
1229205007941	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1229205007942	ATP binding site [chemical binding]; other site
1229205007943	substrate interface [chemical binding]; other site
1229205007944	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1229205007945	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
1229205007946	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1229205007947	protein binding site [polypeptide binding]; other site
1229205007948	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1229205007949	Catalytic dyad [active]
1229205007950	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1229205007951	catalytic core [active]
1229205007952	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1229205007953	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1229205007954	active site residue [active]
1229205007955	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
1229205007956	GSH binding site [chemical binding]; other site
1229205007957	catalytic residues [active]
1229205007958	preprotein translocase subunit SecB; Validated; Region: PRK05751
1229205007959	SecA binding site; other site
1229205007960	Preprotein binding site; other site
1229205007961	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1229205007962	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1229205007963	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1229205007964	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
1229205007965	putative ADP-ribose binding site [chemical binding]; other site
1229205007966	putative active site [active]
1229205007967	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1229205007968	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
1229205007969	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1229205007970	active site
1229205007971	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
1229205007972	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229205007973	S-adenosylmethionine binding site [chemical binding]; other site
1229205007974	Integral membrane protein (DUF2244); Region: DUF2244; pfam10003
1229205007975	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
1229205007976	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
1229205007977	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1229205007978	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1229205007979	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1229205007980	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1229205007981	ligand binding site [chemical binding]; other site
1229205007982	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1229205007983	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
1229205007984	Subunit I/III interface [polypeptide binding]; other site
1229205007985	D-pathway; other site
1229205007986	Subunit I/VIIc interface [polypeptide binding]; other site
1229205007987	Subunit I/IV interface [polypeptide binding]; other site
1229205007988	Subunit I/II interface [polypeptide binding]; other site
1229205007989	Low-spin heme (heme a) binding site [chemical binding]; other site
1229205007990	Subunit I/VIIa interface [polypeptide binding]; other site
1229205007991	Subunit I/VIa interface [polypeptide binding]; other site
1229205007992	Dimer interface; other site
1229205007993	Putative water exit pathway; other site
1229205007994	Binuclear center (heme a3/CuB) [ion binding]; other site
1229205007995	K-pathway; other site
1229205007996	Subunit I/Vb interface [polypeptide binding]; other site
1229205007997	Putative proton exit pathway; other site
1229205007998	Subunit I/VIb interface; other site
1229205007999	Subunit I/VIc interface [polypeptide binding]; other site
1229205008000	Electron transfer pathway; other site
1229205008001	Subunit I/VIIIb interface [polypeptide binding]; other site
1229205008002	Subunit I/VIIb interface [polypeptide binding]; other site
1229205008003	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
1229205008004	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
1229205008005	Subunit III/VIIa interface [polypeptide binding]; other site
1229205008006	Phospholipid binding site [chemical binding]; other site
1229205008007	Subunit I/III interface [polypeptide binding]; other site
1229205008008	Subunit III/VIb interface [polypeptide binding]; other site
1229205008009	Subunit III/VIa interface; other site
1229205008010	Subunit III/Vb interface [polypeptide binding]; other site
1229205008011	Protein of unknown function (DUF2909); Region: DUF2909; pfam11137
1229205008012	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
1229205008013	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
1229205008014	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1229205008015	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
1229205008016	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
1229205008017	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
1229205008018	UbiA prenyltransferase family; Region: UbiA; pfam01040
1229205008019	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
1229205008020	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
1229205008021	Cu(I) binding site [ion binding]; other site
1229205008022	YCII-related domain; Region: YCII; cl00999
1229205008023	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1229205008024	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1229205008025	MarR family; Region: MarR_2; pfam12802
1229205008026	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229205008027	Coenzyme A binding pocket [chemical binding]; other site
1229205008028	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1229205008029	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205008030	DNA-binding site [nucleotide binding]; DNA binding site
1229205008031	UTRA domain; Region: UTRA; pfam07702
1229205008032	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1229205008033	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1229205008034	active site
1229205008035	dimer interface [polypeptide binding]; other site
1229205008036	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
1229205008037	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1229205008038	dimer interface [polypeptide binding]; other site
1229205008039	active site
1229205008040	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1229205008041	dimer interface [polypeptide binding]; other site
1229205008042	active site
1229205008043	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1229205008044	HPr interaction site; other site
1229205008045	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1229205008046	active site
1229205008047	phosphorylation site [posttranslational modification]
1229205008048	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206
1229205008049	dimerization domain swap beta strand [polypeptide binding]; other site
1229205008050	regulatory protein interface [polypeptide binding]; other site
1229205008051	active site
1229205008052	regulatory phosphorylation site [posttranslational modification]; other site
1229205008053	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1229205008054	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1229205008055	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1229205008056	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1229205008057	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1229205008058	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
1229205008059	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1229205008060	active site turn [active]
1229205008061	phosphorylation site [posttranslational modification]
1229205008062	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164
1229205008063	active site turn [active]
1229205008064	phosphorylation site [posttranslational modification]
1229205008065	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
1229205008066	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1229205008067	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1229205008068	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1229205008069	DNA binding residues [nucleotide binding]
1229205008070	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
1229205008071	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
1229205008072	SnoaL-like domain; Region: SnoaL_3; pfam13474
1229205008073	glycosyl transferase family protein; Provisional; Region: PRK08136
1229205008074	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1229205008075	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1229205008076	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1229205008077	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
1229205008078	maleylacetoacetate isomerase; Region: maiA; TIGR01262
1229205008079	C-terminal domain interface [polypeptide binding]; other site
1229205008080	GSH binding site (G-site) [chemical binding]; other site
1229205008081	putative dimer interface [polypeptide binding]; other site
1229205008082	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
1229205008083	dimer interface [polypeptide binding]; other site
1229205008084	N-terminal domain interface [polypeptide binding]; other site
1229205008085	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
1229205008086	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1229205008087	signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064
1229205008088	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1229205008089	P loop; other site
1229205008090	GTP binding site [chemical binding]; other site
1229205008091	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
1229205008092	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229205008093	S-adenosylmethionine binding site [chemical binding]; other site
1229205008094	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1229205008095	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1229205008096	active site
1229205008097	(T/H)XGH motif; other site
1229205008098	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1229205008099	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
1229205008100	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229205008101	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205008102	homodimer interface [polypeptide binding]; other site
1229205008103	catalytic residue [active]
1229205008104	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1229205008105	putative active site [active]
1229205008106	catalytic residue [active]
1229205008107	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
1229205008108	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1229205008109	5S rRNA interface [nucleotide binding]; other site
1229205008110	CTC domain interface [polypeptide binding]; other site
1229205008111	L16 interface [polypeptide binding]; other site
1229205008112	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1229205008113	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1229205008114	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1229205008115	active site
1229205008116	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
1229205008117	outer membrane lipoprotein LolB; Region: lolB; TIGR00548
1229205008118	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
1229205008119	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229205008120	TPR motif; other site
1229205008121	binding surface
1229205008122	TPR repeat; Region: TPR_11; pfam13414
1229205008123	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229205008124	TPR motif; other site
1229205008125	binding surface
1229205008126	TPR repeat; Region: TPR_11; pfam13414
1229205008127	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229205008128	binding surface
1229205008129	TPR motif; other site
1229205008130	TPR repeat; Region: TPR_11; pfam13414
1229205008131	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1229205008132	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1229205008133	DNA binding site [nucleotide binding]
1229205008134	putative catalytic residues [active]
1229205008135	turnover-facilitating residue; other site
1229205008136	intercalation triad [nucleotide binding]; other site
1229205008137	8OG recognition residue [nucleotide binding]; other site
1229205008138	putative reading head residues; other site
1229205008139	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1229205008140	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1229205008141	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
1229205008142	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1229205008143	minor groove reading motif; other site
1229205008144	helix-hairpin-helix signature motif; other site
1229205008145	substrate binding pocket [chemical binding]; other site
1229205008146	active site
1229205008147	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
1229205008148	DNA binding and oxoG recognition site [nucleotide binding]
1229205008149	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
1229205008150	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
1229205008151	HPr kinase/phosphorylase; Provisional; Region: PRK05428
1229205008152	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
1229205008153	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
1229205008154	Hpr binding site; other site
1229205008155	active site
1229205008156	homohexamer subunit interaction site [polypeptide binding]; other site
1229205008157	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1229205008158	active site
1229205008159	phosphorylation site [posttranslational modification]
1229205008160	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1229205008161	30S subunit binding site; other site
1229205008162	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
1229205008163	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
1229205008164	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
1229205008165	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
1229205008166	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
1229205008167	Walker A/P-loop; other site
1229205008168	ATP binding site [chemical binding]; other site
1229205008169	Q-loop/lid; other site
1229205008170	ABC transporter signature motif; other site
1229205008171	Walker B; other site
1229205008172	D-loop; other site
1229205008173	H-loop/switch region; other site
1229205008174	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
1229205008175	OstA-like protein; Region: OstA; pfam03968
1229205008176	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117
1229205008177	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
1229205008178	Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778
1229205008179	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
1229205008180	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
1229205008181	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
1229205008182	putative active site [active]
1229205008183	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
1229205008184	putative cation:proton antiport protein; Provisional; Region: PRK10669
1229205008185	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1229205008186	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1229205008187	TrkA-N domain; Region: TrkA_N; pfam02254
1229205008188	TrkA-C domain; Region: TrkA_C; pfam02080
1229205008189	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1229205008190	active site
1229205008191	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1229205008192	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belong to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_hydrolase_3; cd03676
1229205008193	nudix motif; other site
1229205008194	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
1229205008195	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
1229205008196	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
1229205008197	putative active site [active]
1229205008198	putative substrate binding site [chemical binding]; other site
1229205008199	putative cosubstrate binding site; other site
1229205008200	catalytic site [active]
1229205008201	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1229205008202	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1229205008203	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1229205008204	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1229205008205	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1229205008206	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205008207	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229205008208	putative substrate translocation pore; other site
1229205008209	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1229205008210	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1229205008211	dimer interface [polypeptide binding]; other site
1229205008212	ssDNA binding site [nucleotide binding]; other site
1229205008213	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1229205008214	Tar ligand binding domain homologue; Region: TarH; pfam02203
1229205008215	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1229205008216	dimerization interface [polypeptide binding]; other site
1229205008217	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1229205008218	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1229205008219	dimer interface [polypeptide binding]; other site
1229205008220	putative CheW interface [polypeptide binding]; other site
1229205008221	Cytochrome c; Region: Cytochrom_C; cl11414
1229205008222	Cytochrome c; Region: Cytochrom_C; cl11414
1229205008223	ba3-like heme-copper oxidase subunit I.  The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the...; Region: ba3-like_Oxidase_I; cd01660
1229205008224	Putative D-pathway homolog; other site
1229205008225	Low-spin heme binding site [chemical binding]; other site
1229205008226	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
1229205008227	Subunit I/II interface [polypeptide binding]; other site
1229205008228	Putative Q-pathway; other site
1229205008229	Putative alternate electron transfer pathway; other site
1229205008230	Putative water exit pathway; other site
1229205008231	Binuclear center (active site) [active]
1229205008232	Putative K-pathway homolog; other site
1229205008233	Putative proton exit pathway; other site
1229205008234	Subunit I/IIa interface [polypeptide binding]; other site
1229205008235	Electron transfer pathway; other site
1229205008236	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1229205008237	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1229205008238	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1229205008239	Cytochrome c; Region: Cytochrom_C; pfam00034
1229205008240	Cytochrome c; Region: Cytochrom_C; cl11414
1229205008241	Cytochrome c; Region: Cytochrom_C; cl11414
1229205008242	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205008243	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205008244	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205008245	dimerization interface [polypeptide binding]; other site
1229205008246	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205008247	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1229205008248	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205008249	active site
1229205008250	phosphorylation site [posttranslational modification]
1229205008251	intermolecular recognition site; other site
1229205008252	dimerization interface [polypeptide binding]; other site
1229205008253	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1229205008254	DNA binding residues [nucleotide binding]
1229205008255	dimerization interface [polypeptide binding]; other site
1229205008256	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1229205008257	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205008258	active site
1229205008259	phosphorylation site [posttranslational modification]
1229205008260	intermolecular recognition site; other site
1229205008261	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1229205008262	DNA binding residues [nucleotide binding]
1229205008263	dimerization interface [polypeptide binding]; other site
1229205008264	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
1229205008265	amphipathic channel; other site
1229205008266	Asn-Pro-Ala signature motifs; other site
1229205008267	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1229205008268	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229205008269	substrate binding pocket [chemical binding]; other site
1229205008270	membrane-bound complex binding site; other site
1229205008271	hinge residues; other site
1229205008272	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229205008273	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1229205008274	substrate binding pocket [chemical binding]; other site
1229205008275	membrane-bound complex binding site; other site
1229205008276	hinge residues; other site
1229205008277	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1229205008278	PAS domain; Region: PAS_9; pfam13426
1229205008279	putative active site [active]
1229205008280	heme pocket [chemical binding]; other site
1229205008281	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205008282	dimer interface [polypeptide binding]; other site
1229205008283	phosphorylation site [posttranslational modification]
1229205008284	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205008285	ATP binding site [chemical binding]; other site
1229205008286	Mg2+ binding site [ion binding]; other site
1229205008287	G-X-G motif; other site
1229205008288	Response regulator receiver domain; Region: Response_reg; pfam00072
1229205008289	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205008290	active site
1229205008291	phosphorylation site [posttranslational modification]
1229205008292	intermolecular recognition site; other site
1229205008293	dimerization interface [polypeptide binding]; other site
1229205008294	CHRD domain; Region: CHRD; pfam07452
1229205008295	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1229205008296	EcsC protein family; Region: EcsC; pfam12787
1229205008297	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205008298	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229205008299	putative substrate translocation pore; other site
1229205008300	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205008301	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1229205008302	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1229205008303	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
1229205008304	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818
1229205008305	dimer interface [polypeptide binding]; other site
1229205008306	active site
1229205008307	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1229205008308	substrate binding site [chemical binding]; other site
1229205008309	catalytic residue [active]
1229205008310	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1229205008311	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1229205008312	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1229205008313	putative active site [active]
1229205008314	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
1229205008315	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
1229205008316	active site
1229205008317	putative substrate binding pocket [chemical binding]; other site
1229205008318	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1229205008319	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1229205008320	homotrimer interaction site [polypeptide binding]; other site
1229205008321	putative active site [active]
1229205008322	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
1229205008323	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
1229205008324	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
1229205008325	5'-nucleotidase; Region: 5-nucleotidase; pfam06189
1229205008326	threonine dehydratase; Reviewed; Region: PRK09224
1229205008327	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1229205008328	tetramer interface [polypeptide binding]; other site
1229205008329	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205008330	catalytic residue [active]
1229205008331	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
1229205008332	putative Ile/Val binding site [chemical binding]; other site
1229205008333	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
1229205008334	putative Ile/Val binding site [chemical binding]; other site
1229205008335	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
1229205008336	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1229205008337	putative NAD(P) binding site [chemical binding]; other site
1229205008338	active site
1229205008339	DoxX-like family; Region: DoxX_3; pfam13781
1229205008340	Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027
1229205008341	Protein of unknown function (DUF3683); Region: DUF3683; pfam12447
1229205008342	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1229205008343	FAD binding domain; Region: FAD_binding_4; pfam01565
1229205008344	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1229205008345	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
1229205008346	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1229205008347	Cysteine-rich domain; Region: CCG; pfam02754
1229205008348	Domain of unknown function (DUF3400); Region: DUF3400; pfam11880
1229205008349	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
1229205008350	nucleotide binding site/active site [active]
1229205008351	HIT family signature motif; other site
1229205008352	catalytic residue [active]
1229205008353	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
1229205008354	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1229205008355	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229205008356	S-adenosylmethionine binding site [chemical binding]; other site
1229205008357	Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978
1229205008358	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
1229205008359	SCP-2 sterol transfer family; Region: SCP2; pfam02036
1229205008360	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
1229205008361	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
1229205008362	Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724
1229205008363	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
1229205008364	Uncharacterized conserved protein [Function unknown]; Region: COG2928
1229205008365	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1229205008366	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1229205008367	dimer interface [polypeptide binding]; other site
1229205008368	anticodon binding site; other site
1229205008369	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1229205008370	homodimer interface [polypeptide binding]; other site
1229205008371	motif 1; other site
1229205008372	active site
1229205008373	motif 2; other site
1229205008374	GAD domain; Region: GAD; pfam02938
1229205008375	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1229205008376	motif 3; other site
1229205008377	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
1229205008378	nudix motif; other site
1229205008379	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
1229205008380	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1229205008381	putative active site [active]
1229205008382	catalytic site [active]
1229205008383	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
1229205008384	putative active site [active]
1229205008385	catalytic site [active]
1229205008386	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229205008387	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229205008388	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
1229205008389	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
1229205008390	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
1229205008391	FAD binding site [chemical binding]; other site
1229205008392	substrate binding site [chemical binding]; other site
1229205008393	catalytic residues [active]
1229205008394	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
1229205008395	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
1229205008396	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1229205008397	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1229205008398	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1229205008399	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1229205008400	substrate binding site [chemical binding]; other site
1229205008401	oxyanion hole (OAH) forming residues; other site
1229205008402	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
1229205008403	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1229205008404	dimer interface [polypeptide binding]; other site
1229205008405	active site
1229205008406	enoyl-CoA hydratase; Provisional; Region: PRK06688
1229205008407	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1229205008408	substrate binding site [chemical binding]; other site
1229205008409	oxyanion hole (OAH) forming residues; other site
1229205008410	trimer interface [polypeptide binding]; other site
1229205008411	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
1229205008412	Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655
1229205008413	PAS domain; Region: PAS_8; pfam13188
1229205008414	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1229205008415	PAS domain; Region: PAS_9; pfam13426
1229205008416	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1229205008417	putative active site [active]
1229205008418	heme pocket [chemical binding]; other site
1229205008419	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1229205008420	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1229205008421	metal binding site [ion binding]; metal-binding site
1229205008422	active site
1229205008423	I-site; other site
1229205008424	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1229205008425	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1229205008426	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1229205008427	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
1229205008428	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
1229205008429	Walker A/P-loop; other site
1229205008430	ATP binding site [chemical binding]; other site
1229205008431	Q-loop/lid; other site
1229205008432	ABC transporter signature motif; other site
1229205008433	Walker B; other site
1229205008434	D-loop; other site
1229205008435	H-loop/switch region; other site
1229205008436	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1229205008437	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
1229205008438	Substrate binding site; other site
1229205008439	metal-binding site
1229205008440	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
1229205008441	Phosphotransferase enzyme family; Region: APH; pfam01636
1229205008442	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
1229205008443	Organic solvent tolerance protein; Region: OstA_C; pfam04453
1229205008444	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
1229205008445	SurA N-terminal domain; Region: SurA_N; pfam09312
1229205008446	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1229205008447	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1229205008448	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK01909
1229205008449	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
1229205008450	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1229205008451	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
1229205008452	EamA-like transporter family; Region: EamA; pfam00892
1229205008453	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205008454	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205008455	trimer interface [polypeptide binding]; other site
1229205008456	eyelet of channel; other site
1229205008457	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1229205008458	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
1229205008459	dimer interface [polypeptide binding]; other site
1229205008460	active site
1229205008461	metal binding site [ion binding]; metal-binding site
1229205008462	glutathione binding site [chemical binding]; other site
1229205008463	Protein of unknown function DUF45; Region: DUF45; pfam01863
1229205008464	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1229205008465	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1229205008466	putative acyl-acceptor binding pocket; other site
1229205008467	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
1229205008468	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229205008469	active site
1229205008470	motif I; other site
1229205008471	motif II; other site
1229205008472	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
1229205008473	DALR anticodon binding domain; Region: DALR_1; pfam05746
1229205008474	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
1229205008475	dimer interface [polypeptide binding]; other site
1229205008476	motif 1; other site
1229205008477	active site
1229205008478	motif 2; other site
1229205008479	motif 3; other site
1229205008480	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
1229205008481	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1229205008482	active site
1229205008483	FMN binding site [chemical binding]; other site
1229205008484	substrate binding site [chemical binding]; other site
1229205008485	3Fe-4S cluster binding site [ion binding]; other site
1229205008486	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
1229205008487	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1229205008488	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
1229205008489	nudix motif; other site
1229205008490	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
1229205008491	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
1229205008492	ligand binding site [chemical binding]; other site
1229205008493	homodimer interface [polypeptide binding]; other site
1229205008494	NAD(P) binding site [chemical binding]; other site
1229205008495	trimer interface B [polypeptide binding]; other site
1229205008496	trimer interface A [polypeptide binding]; other site
1229205008497	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
1229205008498	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
1229205008499	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
1229205008500	Predicted transcriptional regulator [Transcription]; Region: COG2378
1229205008501	HTH domain; Region: HTH_11; pfam08279
1229205008502	WYL domain; Region: WYL; pfam13280
1229205008503	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1229205008504	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1229205008505	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
1229205008506	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
1229205008507	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1229205008508	Protein of unknown function (DUF330); Region: DUF330; pfam03886
1229205008509	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
1229205008510	mce related protein; Region: MCE; pfam02470
1229205008511	mce related protein; Region: MCE; pfam02470
1229205008512	mce related protein; Region: MCE; pfam02470
1229205008513	Paraquat-inducible protein A; Region: PqiA; pfam04403
1229205008514	Paraquat-inducible protein A; Region: PqiA; pfam04403
1229205008515	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
1229205008516	YceI-like domain; Region: YceI; smart00867
1229205008517	Uncharacterized conserved protein [Function unknown]; Region: COG2353
1229205008518	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205008519	metabolite-proton symporter; Region: 2A0106; TIGR00883
1229205008520	putative substrate translocation pore; other site
1229205008521	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
1229205008522	Protein export membrane protein; Region: SecD_SecF; pfam02355
1229205008523	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
1229205008524	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
1229205008525	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
1229205008526	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
1229205008527	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
1229205008528	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1229205008529	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1229205008530	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1229205008531	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1229205008532	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1229205008533	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1229205008534	generic binding surface II; other site
1229205008535	ssDNA binding site; other site
1229205008536	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1229205008537	ATP binding site [chemical binding]; other site
1229205008538	putative Mg++ binding site [ion binding]; other site
1229205008539	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1229205008540	nucleotide binding region [chemical binding]; other site
1229205008541	ATP-binding site [chemical binding]; other site
1229205008542	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205008543	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205008544	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
1229205008545	dimerization interface [polypeptide binding]; other site
1229205008546	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1229205008547	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
1229205008548	tetramer interface [polypeptide binding]; other site
1229205008549	heme binding pocket [chemical binding]; other site
1229205008550	NADPH binding site [chemical binding]; other site
1229205008551	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1229205008552	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1229205008553	dimerization interface [polypeptide binding]; other site
1229205008554	DPS ferroxidase diiron center [ion binding]; other site
1229205008555	ion pore; other site
1229205008556	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
1229205008557	UbiA prenyltransferase family; Region: UbiA; pfam01040
1229205008558	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
1229205008559	pyrroline-5-carboxylate reductase; Region: PLN02688
1229205008560	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
1229205008561	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1229205008562	catalytic residue [active]
1229205008563	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
1229205008564	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1229205008565	Cysteine-rich domain; Region: CCG; pfam02754
1229205008566	Cysteine-rich domain; Region: CCG; pfam02754
1229205008567	FAD binding domain; Region: FAD_binding_4; pfam01565
1229205008568	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
1229205008569	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
1229205008570	FAD binding domain; Region: FAD_binding_4; pfam01565
1229205008571	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1229205008572	FAD binding domain; Region: FAD_binding_4; pfam01565
1229205008573	ATP:cob(I)alamin adenosyltransferase; Region: PduO_Nterm; TIGR00636
1229205008574	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
1229205008575	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
1229205008576	heme-binding site [chemical binding]; other site
1229205008577	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
1229205008578	FAD binding pocket [chemical binding]; other site
1229205008579	FAD binding motif [chemical binding]; other site
1229205008580	phosphate binding motif [ion binding]; other site
1229205008581	beta-alpha-beta structure motif; other site
1229205008582	NAD binding pocket [chemical binding]; other site
1229205008583	Heme binding  pocket [chemical binding]; other site
1229205008584	Uncharacterized conserved small protein [Function unknown]; Region: COG5606
1229205008585	non-specific DNA binding site [nucleotide binding]; other site
1229205008586	salt bridge; other site
1229205008587	sequence-specific DNA binding site [nucleotide binding]; other site
1229205008588	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
1229205008589	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
1229205008590	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1229205008591	protease TldD; Provisional; Region: tldD; PRK10735
1229205008592	nitrilase; Region: PLN02798
1229205008593	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
1229205008594	putative active site [active]
1229205008595	catalytic triad [active]
1229205008596	dimer interface [polypeptide binding]; other site
1229205008597	TIGR02099 family protein; Region: TIGR02099
1229205008598	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1229205008599	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
1229205008600	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1229205008601	metal binding triad; other site
1229205008602	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1229205008603	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1229205008604	metal binding triad; other site
1229205008605	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1229205008606	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1229205008607	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1229205008608	Walker A/P-loop; other site
1229205008609	ATP binding site [chemical binding]; other site
1229205008610	Q-loop/lid; other site
1229205008611	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1229205008612	ABC transporter signature motif; other site
1229205008613	Walker B; other site
1229205008614	D-loop; other site
1229205008615	H-loop/switch region; other site
1229205008616	NAD(+)/NADH kinase family protein; Provisional; Region: ppnK; PRK02155
1229205008617	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
1229205008618	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
1229205008619	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
1229205008620	ferrochelatase; Reviewed; Region: hemH; PRK00035
1229205008621	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1229205008622	C-terminal domain interface [polypeptide binding]; other site
1229205008623	active site
1229205008624	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1229205008625	active site
1229205008626	N-terminal domain interface [polypeptide binding]; other site
1229205008627	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1229205008628	RNA binding surface [nucleotide binding]; other site
1229205008629	GrpE; Region: GrpE; pfam01025
1229205008630	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1229205008631	dimer interface [polypeptide binding]; other site
1229205008632	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1229205008633	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1229205008634	catalytic residues [active]
1229205008635	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1229205008636	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1229205008637	nucleotide binding site [chemical binding]; other site
1229205008638	chaperone protein DnaJ; Provisional; Region: PRK10767
1229205008639	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1229205008640	HSP70 interaction site [polypeptide binding]; other site
1229205008641	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1229205008642	Zn binding sites [ion binding]; other site
1229205008643	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1229205008644	dimer interface [polypeptide binding]; other site
1229205008645	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1229205008646	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
1229205008647	hypothetical protein; Provisional; Region: PRK07546
1229205008648	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1229205008649	substrate-cofactor binding pocket; other site
1229205008650	homodimer interface [polypeptide binding]; other site
1229205008651	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205008652	catalytic residue [active]
1229205008653	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1229205008654	oligomerization interface [polypeptide binding]; other site
1229205008655	active site
1229205008656	metal binding site [ion binding]; metal-binding site
1229205008657	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
1229205008658	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
1229205008659	Substrate-binding site [chemical binding]; other site
1229205008660	Substrate specificity [chemical binding]; other site
1229205008661	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1229205008662	catalytic center binding site [active]
1229205008663	ATP binding site [chemical binding]; other site
1229205008664	poly(A) polymerase; Region: pcnB; TIGR01942
1229205008665	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1229205008666	active site
1229205008667	NTP binding site [chemical binding]; other site
1229205008668	metal binding triad [ion binding]; metal-binding site
1229205008669	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1229205008670	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
1229205008671	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1229205008672	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1229205008673	DnaA regulatory inactivator Hda; Validated; Region: PRK08903
1229205008674	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
1229205008675	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1229205008676	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1229205008677	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1229205008678	dimerization interface [polypeptide binding]; other site
1229205008679	putative ATP binding site [chemical binding]; other site
1229205008680	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1229205008681	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1229205008682	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
1229205008683	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205008684	ATP binding site [chemical binding]; other site
1229205008685	Mg2+ binding site [ion binding]; other site
1229205008686	G-X-G motif; other site
1229205008687	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
1229205008688	ATP binding site [chemical binding]; other site
1229205008689	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
1229205008690	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1229205008691	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1229205008692	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
1229205008693	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1229205008694	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1229205008695	ligand binding site [chemical binding]; other site
1229205008696	translocation protein TolB; Provisional; Region: tolB; PRK02889
1229205008697	TolB amino-terminal domain; Region: TolB_N; pfam04052
1229205008698	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1229205008699	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1229205008700	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1229205008701	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1229205008702	TolA protein; Region: tolA_full; TIGR02794
1229205008703	TolA protein; Region: tolA_full; TIGR02794
1229205008704	TonB C terminal; Region: TonB_2; pfam13103
1229205008705	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1229205008706	TolR protein; Region: tolR; TIGR02801
1229205008707	TolQ protein; Region: tolQ; TIGR02796
1229205008708	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1229205008709	active site
1229205008710	malonic semialdehyde reductase; Provisional; Region: PRK10538
1229205008711	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205008712	NAD(P) binding site [chemical binding]; other site
1229205008713	active site
1229205008714	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1229205008715	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1229205008716	dimer interface [polypeptide binding]; other site
1229205008717	active site
1229205008718	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1229205008719	folate binding site [chemical binding]; other site
1229205008720	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1229205008721	ATP cone domain; Region: ATP-cone; pfam03477
1229205008722	Type II transport protein GspH; Region: GspH; pfam12019
1229205008723	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
1229205008724	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
1229205008725	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
1229205008726	Predicted membrane protein [Function unknown]; Region: COG5393
1229205008727	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
1229205008728	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1229205008729	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
1229205008730	dimer interface [polypeptide binding]; other site
1229205008731	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1229205008732	catalytic triad [active]
1229205008733	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
1229205008734	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1229205008735	FAD binding site [chemical binding]; other site
1229205008736	substrate binding pocket [chemical binding]; other site
1229205008737	catalytic base [active]
1229205008738	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1229205008739	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1229205008740	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
1229205008741	homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341
1229205008742	fumarylacetoacetase; Region: PLN02856
1229205008743	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
1229205008744	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1229205008745	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1229205008746	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205008747	putative substrate translocation pore; other site
1229205008748	aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802
1229205008749	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
1229205008750	TrkA-C domain; Region: TrkA_C; pfam02080
1229205008751	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
1229205008752	aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801
1229205008753	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229205008754	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205008755	homodimer interface [polypeptide binding]; other site
1229205008756	catalytic residue [active]
1229205008757	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
1229205008758	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1229205008759	catalytic residue [active]
1229205008760	major facilitator superfamily transporter; Provisional; Region: PRK05122
1229205008761	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
1229205008762	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1229205008763	catalytic loop [active]
1229205008764	iron binding site [ion binding]; other site
1229205008765	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1229205008766	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
1229205008767	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
1229205008768	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1229205008769	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1229205008770	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1229205008771	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205008772	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205008773	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_4; cd08463
1229205008774	putative substrate binding pocket [chemical binding]; other site
1229205008775	putative dimerization interface [polypeptide binding]; other site
1229205008776	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
1229205008777	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1229205008778	putative catalytic residue [active]
1229205008779	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
1229205008780	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
1229205008781	BON domain; Region: BON; cl02771
1229205008782	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1229205008783	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1229205008784	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205008785	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205008786	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
1229205008787	putative dimerization interface [polypeptide binding]; other site
1229205008788	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
1229205008789	active site
1229205008790	catalytic residues [active]
1229205008791	metal binding site [ion binding]; metal-binding site
1229205008792	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1229205008793	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1229205008794	benzoate transport; Region: 2A0115; TIGR00895
1229205008795	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205008796	putative substrate translocation pore; other site
1229205008797	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205008798	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229205008799	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1229205008800	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
1229205008801	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
1229205008802	putative sugar binding sites [chemical binding]; other site
1229205008803	Q-X-W motif; other site
1229205008804	GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430
1229205008805	active site
1229205008806	GDP-Mannose binding site [chemical binding]; other site
1229205008807	dimer interface [polypeptide binding]; other site
1229205008808	modified nudix motif
1229205008809	metal binding site [ion binding]; metal-binding site
1229205008810	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1229205008811	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1229205008812	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205008813	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
1229205008814	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
1229205008815	Substrate binding site; other site
1229205008816	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
1229205008817	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
1229205008818	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1229205008819	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
1229205008820	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
1229205008821	SLBB domain; Region: SLBB; pfam10531
1229205008822	tyrosine kinase; Provisional; Region: PRK11519
1229205008823	Chain length determinant protein; Region: Wzz; pfam02706
1229205008824	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
1229205008825	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
1229205008826	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
1229205008827	NADP-binding site; other site
1229205008828	homotetramer interface [polypeptide binding]; other site
1229205008829	substrate binding site [chemical binding]; other site
1229205008830	homodimer interface [polypeptide binding]; other site
1229205008831	active site
1229205008832	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
1229205008833	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
1229205008834	NADP binding site [chemical binding]; other site
1229205008835	active site
1229205008836	putative substrate binding site [chemical binding]; other site
1229205008837	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229205008838	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1229205008839	putative glycosyl transferase; Provisional; Region: PRK10307
1229205008840	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
1229205008841	putative acyl transferase; Provisional; Region: PRK10502
1229205008842	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
1229205008843	putative trimer interface [polypeptide binding]; other site
1229205008844	putative active site [active]
1229205008845	putative substrate binding site [chemical binding]; other site
1229205008846	putative CoA binding site [chemical binding]; other site
1229205008847	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1229205008848	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1229205008849	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229205008850	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
1229205008851	putative ADP-binding pocket [chemical binding]; other site
1229205008852	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1229205008853	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229205008854	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1229205008855	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1229205008856	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229205008857	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1229205008858	Transcriptional regulator [Transcription]; Region: PaiB; COG2808
1229205008859	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1229205008860	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205008861	DNA-binding site [nucleotide binding]; DNA binding site
1229205008862	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229205008863	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205008864	homodimer interface [polypeptide binding]; other site
1229205008865	catalytic residue [active]
1229205008866	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229205008867	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1229205008868	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
1229205008869	Tannase and feruloyl esterase; Region: Tannase; pfam07519
1229205008870	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1229205008871	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1229205008872	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1229205008873	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229205008874	S-adenosylmethionine binding site [chemical binding]; other site
1229205008875	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1229205008876	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1229205008877	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1229205008878	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229205008879	S-adenosylmethionine binding site [chemical binding]; other site
1229205008880	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1229205008881	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1229205008882	active site
1229205008883	catalytic tetrad [active]
1229205008884	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1229205008885	classical (c) SDRs; Region: SDR_c; cd05233
1229205008886	NAD(P) binding site [chemical binding]; other site
1229205008887	active site
1229205008888	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205008889	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205008890	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
1229205008891	putative effector binding pocket; other site
1229205008892	putative dimerization interface [polypeptide binding]; other site
1229205008893	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1229205008894	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
1229205008895	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1229205008896	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205008897	putative substrate translocation pore; other site
1229205008898	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229205008899	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1229205008900	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205008901	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1229205008902	dimerization interface [polypeptide binding]; other site
1229205008903	substrate binding pocket [chemical binding]; other site
1229205008904	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1229205008905	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205008906	DNA-binding site [nucleotide binding]; DNA binding site
1229205008907	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1229205008908	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205008909	D-galactonate transporter; Region: 2A0114; TIGR00893
1229205008910	putative substrate translocation pore; other site
1229205008911	galactarate dehydratase; Region: galactar-dH20; TIGR03248
1229205008912	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
1229205008913	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
1229205008914	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1229205008915	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
1229205008916	phosphate binding site [ion binding]; other site
1229205008917	Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300
1229205008918	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1229205008919	putative ligand binding site [chemical binding]; other site
1229205008920	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1229205008921	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1229205008922	Walker A/P-loop; other site
1229205008923	ATP binding site [chemical binding]; other site
1229205008924	Q-loop/lid; other site
1229205008925	ABC transporter signature motif; other site
1229205008926	Walker B; other site
1229205008927	D-loop; other site
1229205008928	H-loop/switch region; other site
1229205008929	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1229205008930	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1229205008931	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1229205008932	TM-ABC transporter signature motif; other site
1229205008933	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1229205008934	TM-ABC transporter signature motif; other site
1229205008935	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
1229205008936	Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300
1229205008937	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1229205008938	putative ligand binding site [chemical binding]; other site
1229205008939	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1229205008940	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1229205008941	ligand binding site [chemical binding]; other site
1229205008942	flexible hinge region; other site
1229205008943	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
1229205008944	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1229205008945	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1229205008946	active site
1229205008947	metal binding site [ion binding]; metal-binding site
1229205008948	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205008949	putative substrate translocation pore; other site
1229205008950	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1229205008951	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1229205008952	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1229205008953	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1229205008954	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1229205008955	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
1229205008956	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1229205008957	dimer interface [polypeptide binding]; other site
1229205008958	ADP-ribose binding site [chemical binding]; other site
1229205008959	active site
1229205008960	nudix motif; other site
1229205008961	metal binding site [ion binding]; metal-binding site
1229205008962	Domain of unknown function (DUF4406); Region: DUF4406; pfam14359
1229205008963	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205008964	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205008965	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1229205008966	putative effector binding pocket; other site
1229205008967	dimerization interface [polypeptide binding]; other site
1229205008968	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
1229205008969	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
1229205008970	putative NAD(P) binding site [chemical binding]; other site
1229205008971	dimer interface [polypeptide binding]; other site
1229205008972	Domain of unknown function (DUF336); Region: DUF336; pfam03928
1229205008973	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205008974	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205008975	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
1229205008976	substrate binding pocket [chemical binding]; other site
1229205008977	dimerization interface [polypeptide binding]; other site
1229205008978	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
1229205008979	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1229205008980	catalytic loop [active]
1229205008981	iron binding site [ion binding]; other site
1229205008982	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187
1229205008983	FAD binding pocket [chemical binding]; other site
1229205008984	FAD binding motif [chemical binding]; other site
1229205008985	phosphate binding motif [ion binding]; other site
1229205008986	beta-alpha-beta structure motif; other site
1229205008987	NAD binding pocket [chemical binding]; other site
1229205008988	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1229205008989	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1229205008990	iron-sulfur cluster [ion binding]; other site
1229205008991	[2Fe-2S] cluster binding site [ion binding]; other site
1229205008992	C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880
1229205008993	putative alpha subunit interface [polypeptide binding]; other site
1229205008994	putative active site [active]
1229205008995	putative substrate binding site [chemical binding]; other site
1229205008996	Fe binding site [ion binding]; other site
1229205008997	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
1229205008998	inter-subunit interface; other site
1229205008999	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
1229205009000	[2Fe-2S] cluster binding site [ion binding]; other site
1229205009001	gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272
1229205009002	Cupin domain; Region: Cupin_2; pfam07883
1229205009003	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1229205009004	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1229205009005	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
1229205009006	maleylacetoacetate isomerase; Region: maiA; TIGR01262
1229205009007	C-terminal domain interface [polypeptide binding]; other site
1229205009008	GSH binding site (G-site) [chemical binding]; other site
1229205009009	putative dimer interface [polypeptide binding]; other site
1229205009010	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
1229205009011	dimer interface [polypeptide binding]; other site
1229205009012	N-terminal domain interface [polypeptide binding]; other site
1229205009013	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
1229205009014	MarR family; Region: MarR_2; cl17246
1229205009015	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1229205009016	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1229205009017	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1229205009018	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1229205009019	active site
1229205009020	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
1229205009021	benzoate transport; Region: 2A0115; TIGR00895
1229205009022	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205009023	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205009024	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205009025	trimer interface [polypeptide binding]; other site
1229205009026	eyelet of channel; other site
1229205009027	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
1229205009028	Rossmann-like domain; Region: Rossmann-like; pfam10727
1229205009029	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
1229205009030	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1229205009031	Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109
1229205009032	NAD(P) binding site [chemical binding]; other site
1229205009033	catalytic residues [active]
1229205009034	catalytic residues [active]
1229205009035	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
1229205009036	tartrate dehydrogenase; Region: TTC; TIGR02089
1229205009037	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205009038	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205009039	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205009040	dimerization interface [polypeptide binding]; other site
1229205009041	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1229205009042	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205009043	putative substrate translocation pore; other site
1229205009044	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1229205009045	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1229205009046	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
1229205009047	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1229205009048	phosphate binding site [ion binding]; other site
1229205009049	Cupin domain; Region: Cupin_2; cl17218
1229205009050	polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849
1229205009051	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
1229205009052	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1229205009053	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
1229205009054	putative C-terminal domain interface [polypeptide binding]; other site
1229205009055	putative GSH binding site (G-site) [chemical binding]; other site
1229205009056	putative dimer interface [polypeptide binding]; other site
1229205009057	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
1229205009058	putative N-terminal domain interface [polypeptide binding]; other site
1229205009059	putative dimer interface [polypeptide binding]; other site
1229205009060	putative substrate binding pocket (H-site) [chemical binding]; other site
1229205009061	2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386
1229205009062	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1229205009063	NMT1/THI5 like; Region: NMT1; pfam09084
1229205009064	substrate binding pocket [chemical binding]; other site
1229205009065	membrane-bound complex binding site; other site
1229205009066	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205009067	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205009068	trimer interface [polypeptide binding]; other site
1229205009069	eyelet of channel; other site
1229205009070	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1229205009071	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205009072	putative substrate translocation pore; other site
1229205009073	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
1229205009074	aconitate hydratase; Provisional; Region: acnA; PRK12881
1229205009075	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
1229205009076	substrate binding site [chemical binding]; other site
1229205009077	ligand binding site [chemical binding]; other site
1229205009078	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
1229205009079	substrate binding site [chemical binding]; other site
1229205009080	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205009081	DNA-binding site [nucleotide binding]; DNA binding site
1229205009082	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1229205009083	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1229205009084	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1229205009085	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229205009086	substrate binding pocket [chemical binding]; other site
1229205009087	membrane-bound complex binding site; other site
1229205009088	hinge residues; other site
1229205009089	LysE type translocator; Region: LysE; cl00565
1229205009090	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1229205009091	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1229205009092	active site
1229205009093	non-prolyl cis peptide bond; other site
1229205009094	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1229205009095	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1229205009096	choline dehydrogenase; Validated; Region: PRK02106
1229205009097	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1229205009098	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
1229205009099	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1229205009100	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205009101	dimer interface [polypeptide binding]; other site
1229205009102	conserved gate region; other site
1229205009103	putative PBP binding loops; other site
1229205009104	ABC-ATPase subunit interface; other site
1229205009105	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
1229205009106	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229205009107	Walker A/P-loop; other site
1229205009108	ATP binding site [chemical binding]; other site
1229205009109	Q-loop/lid; other site
1229205009110	ABC transporter signature motif; other site
1229205009111	Walker B; other site
1229205009112	D-loop; other site
1229205009113	H-loop/switch region; other site
1229205009114	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
1229205009115	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1229205009116	NAD binding site [chemical binding]; other site
1229205009117	catalytic residues [active]
1229205009118	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1229205009119	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
1229205009120	conserved cys residue [active]
1229205009121	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205009122	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
1229205009123	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205009124	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205009125	dimerization interface [polypeptide binding]; other site
1229205009126	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1229205009127	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1229205009128	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
1229205009129	active site
1229205009130	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
1229205009131	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1229205009132	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1229205009133	NAD(P) binding site [chemical binding]; other site
1229205009134	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
1229205009135	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205009136	putative substrate translocation pore; other site
1229205009137	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1229205009138	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1229205009139	Cupin domain; Region: Cupin_2; pfam07883
1229205009140	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
1229205009141	chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465
1229205009142	active site
1229205009143	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1229205009144	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205009145	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205009146	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
1229205009147	putative dimerization interface [polypeptide binding]; other site
1229205009148	lipoprotein signal peptidase; Provisional; Region: PRK14787
1229205009149	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
1229205009150	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1229205009151	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
1229205009152	YheO-like PAS domain; Region: PAS_6; pfam08348
1229205009153	HTH domain; Region: HTH_22; pfam13309
1229205009154	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
1229205009155	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
1229205009156	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
1229205009157	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
1229205009158	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1229205009159	catalytic residue [active]
1229205009160	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216
1229205009161	active site
1229205009162	homodimer interface [polypeptide binding]; other site
1229205009163	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1229205009164	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1229205009165	dimerization interface [polypeptide binding]; other site
1229205009166	ligand binding site [chemical binding]; other site
1229205009167	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
1229205009168	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1229205009169	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
1229205009170	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1229205009171	Cl- selectivity filter; other site
1229205009172	Cl- binding residues [ion binding]; other site
1229205009173	pore gating glutamate residue; other site
1229205009174	dimer interface [polypeptide binding]; other site
1229205009175	FOG: CBS domain [General function prediction only]; Region: COG0517
1229205009176	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
1229205009177	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
1229205009178	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
1229205009179	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
1229205009180	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
1229205009181	haemagglutination activity domain; Region: Haemagg_act; pfam05860
1229205009182	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
1229205009183	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1229205009184	putative active site [active]
1229205009185	catalytic site [active]
1229205009186	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
1229205009187	putative active site [active]
1229205009188	catalytic site [active]
1229205009189	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1229205009190	oligomerisation interface [polypeptide binding]; other site
1229205009191	mobile loop; other site
1229205009192	roof hairpin; other site
1229205009193	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1229205009194	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1229205009195	ring oligomerisation interface [polypeptide binding]; other site
1229205009196	ATP/Mg binding site [chemical binding]; other site
1229205009197	stacking interactions; other site
1229205009198	hinge regions; other site
1229205009199	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
1229205009200	ligand-binding site [chemical binding]; other site
1229205009201	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1229205009202	dimer interface [polypeptide binding]; other site
1229205009203	substrate binding site [chemical binding]; other site
1229205009204	ATP binding site [chemical binding]; other site
1229205009205	Rubredoxin [Energy production and conversion]; Region: COG1773
1229205009206	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
1229205009207	iron binding site [ion binding]; other site
1229205009208	hypothetical protein; Validated; Region: PRK00228
1229205009209	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
1229205009210	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1229205009211	active site
1229205009212	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1229205009213	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1229205009214	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1229205009215	dihydroorotase; Provisional; Region: PRK07627
1229205009216	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1229205009217	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1229205009218	active site
1229205009219	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1229205009220	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1229205009221	putative acyl-acceptor binding pocket; other site
1229205009222	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
1229205009223	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
1229205009224	active site
1229205009225	metal binding site [ion binding]; metal-binding site
1229205009226	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1229205009227	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1229205009228	Probable transposase; Region: OrfB_IS605; pfam01385
1229205009229	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1229205009230	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
1229205009231	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1229205009232	NADP-binding site; other site
1229205009233	homotetramer interface [polypeptide binding]; other site
1229205009234	substrate binding site [chemical binding]; other site
1229205009235	homodimer interface [polypeptide binding]; other site
1229205009236	active site
1229205009237	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1229205009238	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1229205009239	NAD binding site [chemical binding]; other site
1229205009240	substrate binding site [chemical binding]; other site
1229205009241	homodimer interface [polypeptide binding]; other site
1229205009242	active site
1229205009243	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1229205009244	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1229205009245	substrate binding site; other site
1229205009246	tetramer interface; other site
1229205009247	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221
1229205009248	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
1229205009249	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1229205009250	NADP binding site [chemical binding]; other site
1229205009251	active site
1229205009252	putative substrate binding site [chemical binding]; other site
1229205009253	RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526
1229205009254	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
1229205009255	Ligand binding site; other site
1229205009256	Integrase core domain; Region: rve; pfam00665
1229205009257	Integrase core domain; Region: rve_3; pfam13683
1229205009258	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1229205009259	Transposase; Region: HTH_Tnp_1; pfam01527
1229205009260	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
1229205009261	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1229205009262	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1229205009263	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1229205009264	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1229205009265	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1229205009266	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1229205009267	HTH-like domain; Region: HTH_21; pfam13276
1229205009268	Transposase; Region: HTH_Tnp_1; cl17663
1229205009269	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1229205009270	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1229205009271	Ligand binding site; other site
1229205009272	Putative Catalytic site; other site
1229205009273	DXD motif; other site
1229205009274	Predicted membrane protein [Function unknown]; Region: COG2246
1229205009275	GtrA-like protein; Region: GtrA; pfam04138
1229205009276	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
1229205009277	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1229205009278	PYR/PP interface [polypeptide binding]; other site
1229205009279	dimer interface [polypeptide binding]; other site
1229205009280	TPP binding site [chemical binding]; other site
1229205009281	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1229205009282	TPP-binding site [chemical binding]; other site
1229205009283	dimer interface [polypeptide binding]; other site
1229205009284	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1229205009285	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205009286	NAD(P) binding site [chemical binding]; other site
1229205009287	active site
1229205009288	lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407
1229205009289	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1229205009290	inhibitor-cofactor binding pocket; inhibition site
1229205009291	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205009292	catalytic residue [active]
1229205009293	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
1229205009294	CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252
1229205009295	NAD binding site [chemical binding]; other site
1229205009296	homotetramer interface [polypeptide binding]; other site
1229205009297	homodimer interface [polypeptide binding]; other site
1229205009298	substrate binding site [chemical binding]; other site
1229205009299	active site
1229205009300	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1229205009301	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
1229205009302	substrate binding site; other site
1229205009303	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
1229205009304	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
1229205009305	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1229205009306	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229205009307	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1229205009308	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1229205009309	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1229205009310	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1229205009311	Walker A/P-loop; other site
1229205009312	ATP binding site [chemical binding]; other site
1229205009313	Q-loop/lid; other site
1229205009314	ABC transporter signature motif; other site
1229205009315	Walker B; other site
1229205009316	D-loop; other site
1229205009317	H-loop/switch region; other site
1229205009318	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1229205009319	Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387
1229205009320	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
1229205009321	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
1229205009322	Mg++ binding site [ion binding]; other site
1229205009323	putative catalytic motif [active]
1229205009324	putative substrate binding site [chemical binding]; other site
1229205009325	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
1229205009326	CoA binding domain; Region: CoA_binding; cl17356
1229205009327	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
1229205009328	NAD(P) binding site [chemical binding]; other site
1229205009329	homodimer interface [polypeptide binding]; other site
1229205009330	substrate binding site [chemical binding]; other site
1229205009331	active site
1229205009332	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
1229205009333	PRTRC system protein D; Region: PRTRC_D; TIGR03739
1229205009334	Mg binding site [ion binding]; other site
1229205009335	nucleotide binding site [chemical binding]; other site
1229205009336	putative protofilament interface [polypeptide binding]; other site
1229205009337	putative transposase OrfB; Reviewed; Region: PHA02517
1229205009338	HTH-like domain; Region: HTH_21; pfam13276
1229205009339	Integrase core domain; Region: rve; pfam00665
1229205009340	Integrase core domain; Region: rve_3; pfam13683
1229205009341	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1229205009342	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1229205009343	DNA-binding interface [nucleotide binding]; DNA binding site
1229205009344	Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834
1229205009345	Integrase; Region: Integrase_1; pfam12835
1229205009346	Nuclease-related domain; Region: NERD; pfam08378
1229205009347	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
1229205009348	This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912
1229205009349	Mg++ binding site [ion binding]; other site
1229205009350	putative catalytic motif [active]
1229205009351	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
1229205009352	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1229205009353	dimerization interface [polypeptide binding]; other site
1229205009354	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1229205009355	dimer interface [polypeptide binding]; other site
1229205009356	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
1229205009357	putative CheW interface [polypeptide binding]; other site
1229205009358	UDP-glucose 4-epimerase; Region: PLN02240
1229205009359	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1229205009360	NAD binding site [chemical binding]; other site
1229205009361	homodimer interface [polypeptide binding]; other site
1229205009362	active site
1229205009363	substrate binding site [chemical binding]; other site
1229205009364	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
1229205009365	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229205009366	putative ADP-binding pocket [chemical binding]; other site
1229205009367	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1229205009368	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1229205009369	active site
1229205009370	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1229205009371	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1229205009372	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
1229205009373	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
1229205009374	active site
1229205009375	substrate binding site [chemical binding]; other site
1229205009376	metal binding site [ion binding]; metal-binding site
1229205009377	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1229205009378	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1229205009379	putative active site [active]
1229205009380	3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004
1229205009381	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
1229205009382	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
1229205009383	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1229205009384	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1229205009385	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
1229205009386	UreF; Region: UreF; pfam01730
1229205009387	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
1229205009388	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
1229205009389	dimer interface [polypeptide binding]; other site
1229205009390	catalytic residues [active]
1229205009391	urease subunit alpha; Reviewed; Region: ureC; PRK13207
1229205009392	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
1229205009393	subunit interactions [polypeptide binding]; other site
1229205009394	active site
1229205009395	flap region; other site
1229205009396	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
1229205009397	gamma-beta subunit interface [polypeptide binding]; other site
1229205009398	alpha-beta subunit interface [polypeptide binding]; other site
1229205009399	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
1229205009400	alpha-gamma subunit interface [polypeptide binding]; other site
1229205009401	beta-gamma subunit interface [polypeptide binding]; other site
1229205009402	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1229205009403	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229205009404	substrate binding pocket [chemical binding]; other site
1229205009405	membrane-bound complex binding site; other site
1229205009406	hinge residues; other site
1229205009407	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
1229205009408	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
1229205009409	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1229205009410	Walker A/P-loop; other site
1229205009411	ATP binding site [chemical binding]; other site
1229205009412	Q-loop/lid; other site
1229205009413	ABC transporter signature motif; other site
1229205009414	Walker B; other site
1229205009415	D-loop; other site
1229205009416	H-loop/switch region; other site
1229205009417	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
1229205009418	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1229205009419	Walker A/P-loop; other site
1229205009420	ATP binding site [chemical binding]; other site
1229205009421	Q-loop/lid; other site
1229205009422	ABC transporter signature motif; other site
1229205009423	Walker B; other site
1229205009424	D-loop; other site
1229205009425	H-loop/switch region; other site
1229205009426	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1229205009427	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1229205009428	TM-ABC transporter signature motif; other site
1229205009429	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1229205009430	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1229205009431	TM-ABC transporter signature motif; other site
1229205009432	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1229205009433	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
1229205009434	putative ligand binding site [chemical binding]; other site
1229205009435	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1229205009436	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1229205009437	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
1229205009438	N-terminal domain interface [polypeptide binding]; other site
1229205009439	dimer interface [polypeptide binding]; other site
1229205009440	substrate binding pocket (H-site) [chemical binding]; other site
1229205009441	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205009442	transcriptional activator TtdR; Provisional; Region: PRK09801
1229205009443	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
1229205009444	putative effector binding pocket; other site
1229205009445	putative dimerization interface [polypeptide binding]; other site
1229205009446	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
1229205009447	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1229205009448	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1229205009449	substrate binding site [chemical binding]; other site
1229205009450	ligand binding site [chemical binding]; other site
1229205009451	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1229205009452	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1229205009453	substrate binding site [chemical binding]; other site
1229205009454	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
1229205009455	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1229205009456	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1229205009457	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205009458	putative substrate translocation pore; other site
1229205009459	Alkylmercury lyase; Region: MerB; pfam03243
1229205009460	Protein of unknown function (DUF3788); Region: DUF3788; pfam12663
1229205009461	Protein of unknown function, DUF417; Region: DUF417; cl01162
1229205009462	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1229205009463	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1229205009464	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
1229205009465	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
1229205009466	C-terminal domain interface [polypeptide binding]; other site
1229205009467	GSH binding site (G-site) [chemical binding]; other site
1229205009468	dimer interface [polypeptide binding]; other site
1229205009469	C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178
1229205009470	dimer interface [polypeptide binding]; other site
1229205009471	N-terminal domain interface [polypeptide binding]; other site
1229205009472	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1229205009473	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
1229205009474	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
1229205009475	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
1229205009476	dimer interface [polypeptide binding]; other site
1229205009477	FMN binding site [chemical binding]; other site
1229205009478	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1229205009479	Cupin; Region: Cupin_6; pfam12852
1229205009480	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205009481	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1229205009482	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205009483	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1229205009484	classical (c) SDRs; Region: SDR_c; cd05233
1229205009485	NAD(P) binding site [chemical binding]; other site
1229205009486	active site
1229205009487	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
1229205009488	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1229205009489	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
1229205009490	dimer interface [polypeptide binding]; other site
1229205009491	FMN binding site [chemical binding]; other site
1229205009492	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1229205009493	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205009494	DNA-binding site [nucleotide binding]; DNA binding site
1229205009495	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229205009496	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205009497	homodimer interface [polypeptide binding]; other site
1229205009498	catalytic residue [active]
1229205009499	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1229205009500	Beta-lactamase; Region: Beta-lactamase; pfam00144
1229205009501	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
1229205009502	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1229205009503	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1229205009504	C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193
1229205009505	putative N-terminal domain interface [polypeptide binding]; other site
1229205009506	putative Mg(2+) transport ATPase; Provisional; Region: PRK09977
1229205009507	MgtC family; Region: MgtC; pfam02308
1229205009508	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
1229205009509	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
1229205009510	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
1229205009511	putative active site [active]
1229205009512	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1229205009513	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1229205009514	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
1229205009515	N-terminal domain interface [polypeptide binding]; other site
1229205009516	dimer interface [polypeptide binding]; other site
1229205009517	substrate binding pocket (H-site) [chemical binding]; other site
1229205009518	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205009519	metabolite-proton symporter; Region: 2A0106; TIGR00883
1229205009520	putative substrate translocation pore; other site
1229205009521	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1229205009522	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
1229205009523	metal binding site [ion binding]; metal-binding site
1229205009524	putative dimer interface [polypeptide binding]; other site
1229205009525	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205009526	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205009527	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205009528	dimerization interface [polypeptide binding]; other site
1229205009529	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1229205009530	classical (c) SDRs; Region: SDR_c; cd05233
1229205009531	NAD(P) binding site [chemical binding]; other site
1229205009532	active site
1229205009533	glutathione S-transferase; Provisional; Region: PRK15113
1229205009534	Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417
1229205009535	C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195
1229205009536	putative substrate binding pocket (H-site) [chemical binding]; other site
1229205009537	N-terminal domain interface [polypeptide binding]; other site
1229205009538	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205009539	H+ Antiporter protein; Region: 2A0121; TIGR00900
1229205009540	putative substrate translocation pore; other site
1229205009541	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
1229205009542	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
1229205009543	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
1229205009544	Winged helix-turn helix; Region: HTH_29; pfam13551
1229205009545	Helix-turn-helix domain; Region: HTH_28; pfam13518
1229205009546	Integrase core domain; Region: rve; pfam00665
1229205009547	Integrase core domain; Region: rve_3; pfam13683
1229205009548	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1229205009549	short chain dehydrogenase; Provisional; Region: PRK06500
1229205009550	classical (c) SDRs; Region: SDR_c; cd05233
1229205009551	NAD(P) binding site [chemical binding]; other site
1229205009552	active site
1229205009553	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
1229205009554	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205009555	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1229205009556	putative effector binding pocket; other site
1229205009557	dimerization interface [polypeptide binding]; other site
1229205009558	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1229205009559	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1229205009560	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1229205009561	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1229205009562	active site residue [active]
1229205009563	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
1229205009564	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229205009565	S-adenosylmethionine binding site [chemical binding]; other site
1229205009566	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1229205009567	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1229205009568	DNA binding site [nucleotide binding]
1229205009569	domain linker motif; other site
1229205009570	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
1229205009571	dimerization interface [polypeptide binding]; other site
1229205009572	ligand binding site [chemical binding]; other site
1229205009573	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1229205009574	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1229205009575	Walker A/P-loop; other site
1229205009576	ATP binding site [chemical binding]; other site
1229205009577	Q-loop/lid; other site
1229205009578	ABC transporter signature motif; other site
1229205009579	Walker B; other site
1229205009580	D-loop; other site
1229205009581	H-loop/switch region; other site
1229205009582	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1229205009583	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1229205009584	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1229205009585	TM-ABC transporter signature motif; other site
1229205009586	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311
1229205009587	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1229205009588	putative ligand binding site [chemical binding]; other site
1229205009589	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1229205009590	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1229205009591	Metal-binding active site; metal-binding site
1229205009592	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
1229205009593	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1229205009594	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1229205009595	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1229205009596	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1229205009597	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
1229205009598	putative ligand binding site [chemical binding]; other site
1229205009599	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684
1229205009600	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205009601	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
1229205009602	substrate binding site [chemical binding]; other site
1229205009603	dimerization interface [polypeptide binding]; other site
1229205009604	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
1229205009605	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1229205009606	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1229205009607	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
1229205009608	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1229205009609	Active Sites [active]
1229205009610	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
1229205009611	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1229205009612	Active Sites [active]
1229205009613	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
1229205009614	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
1229205009615	CysD dimerization site [polypeptide binding]; other site
1229205009616	G1 box; other site
1229205009617	putative GEF interaction site [polypeptide binding]; other site
1229205009618	GTP/Mg2+ binding site [chemical binding]; other site
1229205009619	Switch I region; other site
1229205009620	G2 box; other site
1229205009621	G3 box; other site
1229205009622	Switch II region; other site
1229205009623	G4 box; other site
1229205009624	G5 box; other site
1229205009625	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
1229205009626	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
1229205009627	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1229205009628	active site
1229205009629	SAM binding site [chemical binding]; other site
1229205009630	homodimer interface [polypeptide binding]; other site
1229205009631	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
1229205009632	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
1229205009633	putative active site [active]
1229205009634	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
1229205009635	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1229205009636	Predicted permeases [General function prediction only]; Region: COG0795
1229205009637	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1229205009638	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1229205009639	multifunctional aminopeptidase A; Provisional; Region: PRK00913
1229205009640	interface (dimer of trimers) [polypeptide binding]; other site
1229205009641	Substrate-binding/catalytic site; other site
1229205009642	Zn-binding sites [ion binding]; other site
1229205009643	DNA polymerase III subunit chi; Validated; Region: PRK05728
1229205009644	Protein of unknown function (DUF2486); Region: DUF2486; pfam10667
1229205009645	Cytochrome c; Region: Cytochrom_C; cl11414
1229205009646	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1229205009647	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
1229205009648	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
1229205009649	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205009650	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205009651	dimerization interface [polypeptide binding]; other site
1229205009652	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
1229205009653	Protein of unknown function (DUF541); Region: SIMPL; cl01077
1229205009654	Uncharacterized conserved protein [Function unknown]; Region: COG2947
1229205009655	Cell division protein ZapA; Region: ZapA; pfam05164
1229205009656	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
1229205009657	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1229205009658	N-terminal plug; other site
1229205009659	ligand-binding site [chemical binding]; other site
1229205009660	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1229205009661	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1229205009662	ABC-ATPase subunit  interface; other site
1229205009663	dimer interface [polypeptide binding]; other site
1229205009664	putative PBP binding regions; other site
1229205009665	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1229205009666	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1229205009667	Walker A/P-loop; other site
1229205009668	ATP binding site [chemical binding]; other site
1229205009669	Q-loop/lid; other site
1229205009670	ABC transporter signature motif; other site
1229205009671	Walker B; other site
1229205009672	D-loop; other site
1229205009673	H-loop/switch region; other site
1229205009674	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
1229205009675	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
1229205009676	putative dimer interface [polypeptide binding]; other site
1229205009677	active site pocket [active]
1229205009678	putative cataytic base [active]
1229205009679	cobalamin synthase; Reviewed; Region: cobS; PRK00235
1229205009680	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1229205009681	catalytic core [active]
1229205009682	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
1229205009683	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
1229205009684	cobalamin binding residues [chemical binding]; other site
1229205009685	putative BtuC binding residues; other site
1229205009686	dimer interface [polypeptide binding]; other site
1229205009687	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
1229205009688	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229205009689	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205009690	homodimer interface [polypeptide binding]; other site
1229205009691	catalytic residue [active]
1229205009692	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
1229205009693	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
1229205009694	homotrimer interface [polypeptide binding]; other site
1229205009695	Walker A motif; other site
1229205009696	GTP binding site [chemical binding]; other site
1229205009697	Walker B motif; other site
1229205009698	cobyric acid synthase; Provisional; Region: PRK00784
1229205009699	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
1229205009700	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1229205009701	catalytic triad [active]
1229205009702	Predicted membrane protein [Function unknown]; Region: COG2259
1229205009703	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1229205009704	CoenzymeA binding site [chemical binding]; other site
1229205009705	subunit interaction site [polypeptide binding]; other site
1229205009706	PHB binding site; other site
1229205009707	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1229205009708	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1229205009709	P-loop; other site
1229205009710	Magnesium ion binding site [ion binding]; other site
1229205009711	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
1229205009712	tetramerization interface [polypeptide binding]; other site
1229205009713	active site
1229205009714	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1229205009715	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1229205009716	active site
1229205009717	ATP-binding site [chemical binding]; other site
1229205009718	pantoate-binding site; other site
1229205009719	HXXH motif; other site
1229205009720	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
1229205009721	Protein of unknown function (DUF3460); Region: DUF3460; pfam11943
1229205009722	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
1229205009723	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1229205009724	Surface antigen; Region: Bac_surface_Ag; pfam01103
1229205009725	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
1229205009726	Family of unknown function (DUF490); Region: DUF490; pfam04357
1229205009727	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
1229205009728	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1229205009729	active site
1229205009730	HIGH motif; other site
1229205009731	KMSKS motif; other site
1229205009732	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1229205009733	tRNA binding surface [nucleotide binding]; other site
1229205009734	anticodon binding site; other site
1229205009735	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1229205009736	dimer interface [polypeptide binding]; other site
1229205009737	putative tRNA-binding site [nucleotide binding]; other site
1229205009738	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1229205009739	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1229205009740	ligand binding site [chemical binding]; other site
1229205009741	Domain of unknown function DUF59; Region: DUF59; pfam01883
1229205009742	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
1229205009743	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1229205009744	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
1229205009745	Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080
1229205009746	E-class dimer interface [polypeptide binding]; other site
1229205009747	P-class dimer interface [polypeptide binding]; other site
1229205009748	active site
1229205009749	Cu2+ binding site [ion binding]; other site
1229205009750	Zn2+ binding site [ion binding]; other site
1229205009751	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1229205009752	trimer interface [polypeptide binding]; other site
1229205009753	active site
1229205009754	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
1229205009755	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
1229205009756	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1229205009757	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1229205009758	catalytic residue [active]
1229205009759	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1229205009760	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
1229205009761	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544
1229205009762	bifunctional glucokinase/RpiR family transcriptional regulator; Provisional; Region: PRK14101
1229205009763	glucokinase; Provisional; Region: glk; PRK00292
1229205009764	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1229205009765	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1229205009766	putative active site [active]
1229205009767	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1229205009768	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
1229205009769	putative active site [active]
1229205009770	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1229205009771	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1229205009772	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1229205009773	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1229205009774	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1229205009775	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1229205009776	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205009777	putative PBP binding loops; other site
1229205009778	dimer interface [polypeptide binding]; other site
1229205009779	ABC-ATPase subunit interface; other site
1229205009780	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1229205009781	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205009782	dimer interface [polypeptide binding]; other site
1229205009783	conserved gate region; other site
1229205009784	putative PBP binding loops; other site
1229205009785	ABC-ATPase subunit interface; other site
1229205009786	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1229205009787	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1229205009788	Walker A/P-loop; other site
1229205009789	ATP binding site [chemical binding]; other site
1229205009790	Q-loop/lid; other site
1229205009791	ABC transporter signature motif; other site
1229205009792	Walker B; other site
1229205009793	D-loop; other site
1229205009794	H-loop/switch region; other site
1229205009795	TOBE domain; Region: TOBE; cl01440
1229205009796	transcriptional regulator; Provisional; Region: PRK10632
1229205009797	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205009798	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
1229205009799	putative effector binding pocket; other site
1229205009800	putative dimerization interface [polypeptide binding]; other site
1229205009801	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1229205009802	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
1229205009803	C-terminal domain interface [polypeptide binding]; other site
1229205009804	GSH binding site (G-site) [chemical binding]; other site
1229205009805	dimer interface [polypeptide binding]; other site
1229205009806	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
1229205009807	dimer interface [polypeptide binding]; other site
1229205009808	N-terminal domain interface [polypeptide binding]; other site
1229205009809	substrate binding pocket (H-site) [chemical binding]; other site
1229205009810	Predicted membrane protein [Function unknown]; Region: COG2860
1229205009811	UPF0126 domain; Region: UPF0126; pfam03458
1229205009812	UPF0126 domain; Region: UPF0126; pfam03458
1229205009813	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
1229205009814	Smr domain; Region: Smr; pfam01713
1229205009815	thioredoxin reductase; Provisional; Region: PRK10262
1229205009816	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1229205009817	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1229205009818	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
1229205009819	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1229205009820	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1229205009821	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
1229205009822	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
1229205009823	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205009824	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205009825	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1229205009826	dimerization interface [polypeptide binding]; other site
1229205009827	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
1229205009828	agmatinase; Region: agmatinase; TIGR01230
1229205009829	oligomer interface [polypeptide binding]; other site
1229205009830	putative active site [active]
1229205009831	Mn binding site [ion binding]; other site
1229205009832	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1229205009833	recombination factor protein RarA; Reviewed; Region: PRK13342
1229205009834	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205009835	Walker A motif; other site
1229205009836	ATP binding site [chemical binding]; other site
1229205009837	Walker B motif; other site
1229205009838	arginine finger; other site
1229205009839	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1229205009840	seryl-tRNA synthetase; Provisional; Region: PRK05431
1229205009841	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1229205009842	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1229205009843	dimer interface [polypeptide binding]; other site
1229205009844	active site
1229205009845	motif 1; other site
1229205009846	motif 2; other site
1229205009847	motif 3; other site
1229205009848	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1229205009849	active site
1229205009850	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229205009851	Coenzyme A binding pocket [chemical binding]; other site
1229205009852	septum formation inhibitor; Reviewed; Region: PRK01973
1229205009853	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
1229205009854	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
1229205009855	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
1229205009856	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
1229205009857	Switch I; other site
1229205009858	Switch II; other site
1229205009859	cell division topological specificity factor MinE; Provisional; Region: PRK13989
1229205009860	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1229205009861	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
1229205009862	putative ion selectivity filter; other site
1229205009863	putative pore gating glutamate residue; other site
1229205009864	putative H+/Cl- coupling transport residue; other site
1229205009865	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1229205009866	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1229205009867	putative active site [active]
1229205009868	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205009869	metabolite-proton symporter; Region: 2A0106; TIGR00883
1229205009870	putative substrate translocation pore; other site
1229205009871	Gram-negative bacterial tonB protein; Region: TonB; cl10048
1229205009872	argininosuccinate lyase; Provisional; Region: PRK00855
1229205009873	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1229205009874	active sites [active]
1229205009875	tetramer interface [polypeptide binding]; other site
1229205009876	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229205009877	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1229205009878	sequence-specific DNA binding site [nucleotide binding]; other site
1229205009879	salt bridge; other site
1229205009880	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1229205009881	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229205009882	S-adenosylmethionine binding site [chemical binding]; other site
1229205009883	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
1229205009884	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
1229205009885	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
1229205009886	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1229205009887	active site
1229205009888	domain interfaces; other site
1229205009889	bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975
1229205009890	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1229205009891	active site
1229205009892	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
1229205009893	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
1229205009894	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229205009895	TPR motif; other site
1229205009896	binding surface
1229205009897	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
1229205009898	active site
1229205009899	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
1229205009900	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205009901	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the chlorocatechol catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_Chlorocatechol; cd08446
1229205009902	dimerization interface [polypeptide binding]; other site
1229205009903	putative substrate binding pocket [chemical binding]; other site
1229205009904	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1229205009905	active site 1 [active]
1229205009906	dimer interface [polypeptide binding]; other site
1229205009907	hexamer interface [polypeptide binding]; other site
1229205009908	active site 2 [active]
1229205009909	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
1229205009910	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
1229205009911	acetaldehyde dehydrogenase; Validated; Region: PRK08300
1229205009912	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1229205009913	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
1229205009914	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
1229205009915	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
1229205009916	active site
1229205009917	catalytic residues [active]
1229205009918	metal binding site [ion binding]; metal-binding site
1229205009919	DmpG-like communication domain; Region: DmpG_comm; pfam07836
1229205009920	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1229205009921	Spore germination protein; Region: Spore_permease; cl17796
1229205009922	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229205009923	Coenzyme A binding pocket [chemical binding]; other site
1229205009924	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
1229205009925	arsenical-resistance protein; Region: acr3; TIGR00832
1229205009926	Low molecular weight phosphatase family; Region: LMWPc; cl00105
1229205009927	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1229205009928	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1229205009929	putative DNA binding site [nucleotide binding]; other site
1229205009930	putative Zn2+ binding site [ion binding]; other site
1229205009931	Cupin; Region: Cupin_6; pfam12852
1229205009932	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205009933	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1229205009934	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205009935	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1229205009936	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1229205009937	NAD(P) binding site [chemical binding]; other site
1229205009938	oxidoreductase; Provisional; Region: PRK06196
1229205009939	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
1229205009940	putative NAD(P) binding site [chemical binding]; other site
1229205009941	active site
1229205009942	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1229205009943	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1229205009944	NADP binding site [chemical binding]; other site
1229205009945	active site
1229205009946	steroid binding site; other site
1229205009947	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205009948	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
1229205009949	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1229205009950	putative effector binding pocket; other site
1229205009951	dimerization interface [polypeptide binding]; other site
1229205009952	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1229205009953	NmrA (a transcriptional regulator) and triphenylmethane reductase (TMR) like proteins, subgroup 1, atypical (a) SDRs; Region: NmrA_TMR_like_1_SDR_a; cd05231
1229205009954	putative NADP binding site [chemical binding]; other site
1229205009955	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1229205009956	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1229205009957	dimer interface [polypeptide binding]; other site
1229205009958	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205009959	catalytic residue [active]
1229205009960	Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703
1229205009961	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1229205009962	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1229205009963	DNA binding residues [nucleotide binding]
1229205009964	dimerization interface [polypeptide binding]; other site
1229205009965	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1229205009966	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1229205009967	NAD(P) binding site [chemical binding]; other site
1229205009968	catalytic residues [active]
1229205009969	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205009970	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1229205009971	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205009972	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1229205009973	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205009974	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205009975	trimer interface [polypeptide binding]; other site
1229205009976	eyelet of channel; other site
1229205009977	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1229205009978	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1229205009979	Protein of unknown function (DUF861); Region: Cupin_3; cl17594
1229205009980	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1229205009981	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205009982	putative substrate translocation pore; other site
1229205009983	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345
1229205009984	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
1229205009985	putative NAD(P) binding site [chemical binding]; other site
1229205009986	active site
1229205009987	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1229205009988	Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109
1229205009989	NAD(P) binding site [chemical binding]; other site
1229205009990	catalytic residues [active]
1229205009991	catalytic residues [active]
1229205009992	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
1229205009993	dimer interface [polypeptide binding]; other site
1229205009994	substrate binding site [chemical binding]; other site
1229205009995	metal binding sites [ion binding]; metal-binding site
1229205009996	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1229205009997	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
1229205009998	GIY-YIG motif/motif A; other site
1229205009999	putative active site [active]
1229205010000	putative metal binding site [ion binding]; other site
1229205010001	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
1229205010002	Protein of unknown function, DUF482; Region: DUF482; pfam04339
1229205010003	NAD synthetase; Provisional; Region: PRK13981
1229205010004	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
1229205010005	multimer interface [polypeptide binding]; other site
1229205010006	active site
1229205010007	catalytic triad [active]
1229205010008	protein interface 1 [polypeptide binding]; other site
1229205010009	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1229205010010	homodimer interface [polypeptide binding]; other site
1229205010011	NAD binding pocket [chemical binding]; other site
1229205010012	ATP binding pocket [chemical binding]; other site
1229205010013	Mg binding site [ion binding]; other site
1229205010014	active-site loop [active]
1229205010015	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
1229205010016	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1229205010017	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205010018	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205010019	trimer interface [polypeptide binding]; other site
1229205010020	eyelet of channel; other site
1229205010021	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
1229205010022	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1229205010023	Walker A/P-loop; other site
1229205010024	ATP binding site [chemical binding]; other site
1229205010025	Q-loop/lid; other site
1229205010026	ABC transporter signature motif; other site
1229205010027	Walker B; other site
1229205010028	D-loop; other site
1229205010029	H-loop/switch region; other site
1229205010030	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1229205010031	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205010032	dimer interface [polypeptide binding]; other site
1229205010033	conserved gate region; other site
1229205010034	putative PBP binding loops; other site
1229205010035	ABC-ATPase subunit interface; other site
1229205010036	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1229205010037	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205010038	dimer interface [polypeptide binding]; other site
1229205010039	conserved gate region; other site
1229205010040	putative PBP binding loops; other site
1229205010041	ABC-ATPase subunit interface; other site
1229205010042	ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010
1229205010043	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229205010044	substrate binding pocket [chemical binding]; other site
1229205010045	membrane-bound complex binding site; other site
1229205010046	hinge residues; other site
1229205010047	Pirin-related protein [General function prediction only]; Region: COG1741
1229205010048	Pirin; Region: Pirin; pfam02678
1229205010049	Heavy-metal resistance; Region: Metal_resist; pfam13801
1229205010050	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1229205010051	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205010052	active site
1229205010053	phosphorylation site [posttranslational modification]
1229205010054	intermolecular recognition site; other site
1229205010055	dimerization interface [polypeptide binding]; other site
1229205010056	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229205010057	DNA binding site [nucleotide binding]
1229205010058	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
1229205010059	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205010060	dimer interface [polypeptide binding]; other site
1229205010061	phosphorylation site [posttranslational modification]
1229205010062	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205010063	ATP binding site [chemical binding]; other site
1229205010064	Mg2+ binding site [ion binding]; other site
1229205010065	G-X-G motif; other site
1229205010066	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
1229205010067	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1229205010068	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1229205010069	metal binding site [ion binding]; metal-binding site
1229205010070	active site
1229205010071	I-site; other site
1229205010072	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
1229205010073	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205010074	dimer interface [polypeptide binding]; other site
1229205010075	conserved gate region; other site
1229205010076	putative PBP binding loops; other site
1229205010077	ABC-ATPase subunit interface; other site
1229205010078	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205010079	dimer interface [polypeptide binding]; other site
1229205010080	conserved gate region; other site
1229205010081	putative PBP binding loops; other site
1229205010082	ABC-ATPase subunit interface; other site
1229205010083	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1229205010084	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1229205010085	Walker A/P-loop; other site
1229205010086	ATP binding site [chemical binding]; other site
1229205010087	Q-loop/lid; other site
1229205010088	ABC transporter signature motif; other site
1229205010089	Walker B; other site
1229205010090	D-loop; other site
1229205010091	H-loop/switch region; other site
1229205010092	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
1229205010093	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
1229205010094	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205010095	Walker A motif; other site
1229205010096	ATP binding site [chemical binding]; other site
1229205010097	Walker B motif; other site
1229205010098	arginine finger; other site
1229205010099	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1229205010100	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
1229205010101	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1229205010102	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205010103	active site
1229205010104	phosphorylation site [posttranslational modification]
1229205010105	intermolecular recognition site; other site
1229205010106	dimerization interface [polypeptide binding]; other site
1229205010107	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205010108	Walker A motif; other site
1229205010109	ATP binding site [chemical binding]; other site
1229205010110	Walker B motif; other site
1229205010111	arginine finger; other site
1229205010112	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1229205010113	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
1229205010114	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
1229205010115	active site
1229205010116	homotetramer interface [polypeptide binding]; other site
1229205010117	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205010118	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229205010119	putative substrate translocation pore; other site
1229205010120	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1229205010121	substrate binding site [chemical binding]; other site
1229205010122	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
1229205010123	additional DNA contacts [nucleotide binding]; other site
1229205010124	mismatch recognition site; other site
1229205010125	active site
1229205010126	zinc binding site [ion binding]; other site
1229205010127	DNA intercalation site [nucleotide binding]; other site
1229205010128	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205010129	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205010130	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1229205010131	dimerization interface [polypeptide binding]; other site
1229205010132	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205010133	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205010134	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1229205010135	dimerization interface [polypeptide binding]; other site
1229205010136	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1229205010137	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1229205010138	Walker A/P-loop; other site
1229205010139	ATP binding site [chemical binding]; other site
1229205010140	Q-loop/lid; other site
1229205010141	ABC transporter signature motif; other site
1229205010142	Walker B; other site
1229205010143	D-loop; other site
1229205010144	H-loop/switch region; other site
1229205010145	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205010146	dimer interface [polypeptide binding]; other site
1229205010147	conserved gate region; other site
1229205010148	putative PBP binding loops; other site
1229205010149	ABC-ATPase subunit interface; other site
1229205010150	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1229205010151	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205010152	dimer interface [polypeptide binding]; other site
1229205010153	conserved gate region; other site
1229205010154	putative PBP binding loops; other site
1229205010155	ABC-ATPase subunit interface; other site
1229205010156	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1229205010157	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229205010158	substrate binding pocket [chemical binding]; other site
1229205010159	membrane-bound complex binding site; other site
1229205010160	hinge residues; other site
1229205010161	CheD chemotactic sensory transduction; Region: CheD; cl00810
1229205010162	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
1229205010163	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205010164	The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415
1229205010165	putative dimerization interface [polypeptide binding]; other site
1229205010166	Serine hydrolase; Region: Ser_hydrolase; cl17834
1229205010167	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1229205010168	Homeodomain-like domain; Region: HTH_23; pfam13384
1229205010169	DNA cytosine methylase; Provisional; Region: PRK10458
1229205010170	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1229205010171	cofactor binding site; other site
1229205010172	DNA binding site [nucleotide binding]
1229205010173	substrate interaction site [chemical binding]; other site
1229205010174	CsbD-like; Region: CsbD; pfam05532
1229205010175	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1229205010176	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
1229205010177	C-terminal domain interface [polypeptide binding]; other site
1229205010178	GSH binding site (G-site) [chemical binding]; other site
1229205010179	dimer interface [polypeptide binding]; other site
1229205010180	C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178
1229205010181	dimer interface [polypeptide binding]; other site
1229205010182	N-terminal domain interface [polypeptide binding]; other site
1229205010183	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
1229205010184	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1229205010185	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1229205010186	catalytic residues [active]
1229205010187	catalytic nucleophile [active]
1229205010188	Presynaptic Site I dimer interface [polypeptide binding]; other site
1229205010189	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1229205010190	Synaptic Flat tetramer interface [polypeptide binding]; other site
1229205010191	Synaptic Site I dimer interface [polypeptide binding]; other site
1229205010192	DNA binding site [nucleotide binding]
1229205010193	hypothetical protein; Region: PHA00672
1229205010194	Protein of unknown function (DUF2806); Region: DUF2806; cl12560
1229205010195	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1229205010196	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1229205010197	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1229205010198	active site
1229205010199	Int/Topo IB signature motif; other site
1229205010200	DNA binding site [nucleotide binding]
1229205010201	Predicted periplasmic lipoprotein (DUF2279); Region: DUF2279; pfam10043
1229205010202	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
1229205010203	Rubredoxin; Region: Rubredoxin; pfam00301
1229205010204	iron binding site [ion binding]; other site
1229205010205	Domain of unknown function (DUF4399); Region: DUF4399; pfam14347
1229205010206	ABC transporter ATPase component; Reviewed; Region: PRK11147
1229205010207	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229205010208	Walker A/P-loop; other site
1229205010209	ATP binding site [chemical binding]; other site
1229205010210	Q-loop/lid; other site
1229205010211	ABC transporter signature motif; other site
1229205010212	Walker B; other site
1229205010213	D-loop; other site
1229205010214	H-loop/switch region; other site
1229205010215	ABC transporter; Region: ABC_tran_2; pfam12848
1229205010216	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1229205010217	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
1229205010218	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205010219	ATP binding site [chemical binding]; other site
1229205010220	Mg2+ binding site [ion binding]; other site
1229205010221	G-X-G motif; other site
1229205010222	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1229205010223	anchoring element; other site
1229205010224	dimer interface [polypeptide binding]; other site
1229205010225	ATP binding site [chemical binding]; other site
1229205010226	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
1229205010227	active site
1229205010228	metal binding site [ion binding]; metal-binding site
1229205010229	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1229205010230	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
1229205010231	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1229205010232	CAP-like domain; other site
1229205010233	active site
1229205010234	primary dimer interface [polypeptide binding]; other site
1229205010235	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1229205010236	Predicted integral membrane protein [Function unknown]; Region: COG5615
1229205010237	Chromate transporter; Region: Chromate_transp; pfam02417
1229205010238	Chromate transporter; Region: Chromate_transp; pfam02417
1229205010239	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1229205010240	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1229205010241	metal binding site [ion binding]; metal-binding site
1229205010242	active site
1229205010243	I-site; other site
1229205010244	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1229205010245	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
1229205010246	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
1229205010247	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
1229205010248	homotrimer interaction site [polypeptide binding]; other site
1229205010249	putative active site [active]
1229205010250	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
1229205010251	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229205010252	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205010253	homodimer interface [polypeptide binding]; other site
1229205010254	catalytic residue [active]
1229205010255	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
1229205010256	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1229205010257	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205010258	DNA-binding site [nucleotide binding]; DNA binding site
1229205010259	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229205010260	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205010261	homodimer interface [polypeptide binding]; other site
1229205010262	catalytic residue [active]
1229205010263	heat shock protein 90; Provisional; Region: PRK05218
1229205010264	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205010265	ATP binding site [chemical binding]; other site
1229205010266	Mg2+ binding site [ion binding]; other site
1229205010267	G-X-G motif; other site
1229205010268	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229205010269	TPR motif; other site
1229205010270	binding surface
1229205010271	TPR repeat; Region: TPR_11; pfam13414
1229205010272	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229205010273	binding surface
1229205010274	TPR motif; other site
1229205010275	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1229205010276	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1229205010277	putative outer membrane lipoprotein; Provisional; Region: PRK09967
1229205010278	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1229205010279	ligand binding site [chemical binding]; other site
1229205010280	Chorismate lyase; Region: Chor_lyase; cl01230
1229205010281	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
1229205010282	putative active site [active]
1229205010283	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1229205010284	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
1229205010285	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
1229205010286	Na binding site [ion binding]; other site
1229205010287	Predicted membrane protein [Function unknown]; Region: COG1289
1229205010288	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1229205010289	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1229205010290	dimer interface [polypeptide binding]; other site
1229205010291	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1229205010292	transaldolase-like protein; Provisional; Region: PTZ00411
1229205010293	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
1229205010294	active site
1229205010295	dimer interface [polypeptide binding]; other site
1229205010296	catalytic residue [active]
1229205010297	benzoate transporter; Region: benE; TIGR00843
1229205010298	Benzoate membrane transport protein; Region: BenE; pfam03594
1229205010299	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
1229205010300	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1229205010301	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205010302	Walker A motif; other site
1229205010303	ATP binding site [chemical binding]; other site
1229205010304	Walker B motif; other site
1229205010305	arginine finger; other site
1229205010306	Cytochrome c; Region: Cytochrom_C; cl11414
1229205010307	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1229205010308	Cytochrome c; Region: Cytochrom_C; cl11414
1229205010309	Domain of unknown function (DUF1841); Region: DUF1841; pfam08897
1229205010310	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1229205010311	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1229205010312	minor groove reading motif; other site
1229205010313	helix-hairpin-helix signature motif; other site
1229205010314	substrate binding pocket [chemical binding]; other site
1229205010315	active site
1229205010316	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
1229205010317	ferredoxin; Provisional; Region: PRK06991
1229205010318	Putative Fe-S cluster; Region: FeS; pfam04060
1229205010319	4Fe-4S binding domain; Region: Fer4; pfam00037
1229205010320	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
1229205010321	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229205010322	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
1229205010323	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
1229205010324	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
1229205010325	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
1229205010326	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
1229205010327	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
1229205010328	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1229205010329	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1229205010330	META domain; Region: META; pfam03724
1229205010331	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
1229205010332	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205010333	ATP-grasp domain; Region: ATP-grasp; pfam02222
1229205010334	Predicted periplasmic protein [General function prediction only]; Region: COG3895
1229205010335	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
1229205010336	acetolactate synthase; Reviewed; Region: PRK08322
1229205010337	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1229205010338	PYR/PP interface [polypeptide binding]; other site
1229205010339	dimer interface [polypeptide binding]; other site
1229205010340	TPP binding site [chemical binding]; other site
1229205010341	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1229205010342	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
1229205010343	TPP-binding site [chemical binding]; other site
1229205010344	dimer interface [polypeptide binding]; other site
1229205010345	Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147
1229205010346	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1229205010347	NAD(P) binding site [chemical binding]; other site
1229205010348	catalytic residues [active]
1229205010349	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1229205010350	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1229205010351	ATP binding site [chemical binding]; other site
1229205010352	Mg++ binding site [ion binding]; other site
1229205010353	motif III; other site
1229205010354	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1229205010355	nucleotide binding region [chemical binding]; other site
1229205010356	ATP-binding site [chemical binding]; other site
1229205010357	Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008
1229205010358	glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838
1229205010359	active site
1229205010360	HIGH motif; other site
1229205010361	nucleotide binding site [chemical binding]; other site
1229205010362	active site
1229205010363	KMSKS motif; other site
1229205010364	rhodanese superfamily protein; Provisional; Region: PRK05320
1229205010365	Acylphosphatase; Region: Acylphosphatase; cl00551
1229205010366	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
1229205010367	active site residue [active]
1229205010368	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
1229205010369	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
1229205010370	putative active site [active]
1229205010371	putative PHP Thumb interface [polypeptide binding]; other site
1229205010372	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1229205010373	generic binding surface II; other site
1229205010374	generic binding surface I; other site
1229205010375	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
1229205010376	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1229205010377	putative metal binding site; other site
1229205010378	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
1229205010379	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1229205010380	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1229205010381	Walker A/P-loop; other site
1229205010382	ATP binding site [chemical binding]; other site
1229205010383	Q-loop/lid; other site
1229205010384	ABC transporter signature motif; other site
1229205010385	Walker B; other site
1229205010386	D-loop; other site
1229205010387	H-loop/switch region; other site
1229205010388	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1229205010389	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
1229205010390	Probable Catalytic site; other site
1229205010391	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1229205010392	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1229205010393	active site
1229205010394	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
1229205010395	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1229205010396	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229205010397	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
1229205010398	O-Antigen ligase; Region: Wzy_C; pfam04932
1229205010399	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1229205010400	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1229205010401	active site
1229205010402	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
1229205010403	recombination associated protein; Reviewed; Region: rdgC; PRK00321
1229205010404	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
1229205010405	putative dimer interface [polypeptide binding]; other site
1229205010406	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1229205010407	NLPC_P60 stabilising domain, N term; Region: N_NLPC_P60; pfam12912
1229205010408	SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913
1229205010409	SH3 domain of SH3b2 type; Region: SH3_7; pfam12914
1229205010410	NlpC/P60 family; Region: NLPC_P60; cl17555
1229205010411	molybdenum-pterin binding domain; Region: Mop; TIGR00638
1229205010412	TOBE domain; Region: TOBE; cl01440
1229205010413	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
1229205010414	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1229205010415	putative active site [active]
1229205010416	heme pocket [chemical binding]; other site
1229205010417	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1229205010418	metal binding site [ion binding]; metal-binding site
1229205010419	active site
1229205010420	I-site; other site
1229205010421	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1229205010422	ribonuclease G; Provisional; Region: PRK11712
1229205010423	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1229205010424	homodimer interface [polypeptide binding]; other site
1229205010425	oligonucleotide binding site [chemical binding]; other site
1229205010426	Maf-like protein; Region: Maf; pfam02545
1229205010427	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1229205010428	active site
1229205010429	dimer interface [polypeptide binding]; other site
1229205010430	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
1229205010431	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
1229205010432	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1229205010433	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
1229205010434	active site
1229205010435	(T/H)XGH motif; other site
1229205010436	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
1229205010437	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
1229205010438	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1229205010439	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1229205010440	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1229205010441	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1229205010442	hypothetical protein; Validated; Region: PRK00110
1229205010443	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1229205010444	active site
1229205010445	short chain dehydrogenase; Provisional; Region: PRK08339
1229205010446	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
1229205010447	putative NAD(P) binding site [chemical binding]; other site
1229205010448	putative active site [active]
1229205010449	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
1229205010450	active site
1229205010451	dimer interfaces [polypeptide binding]; other site
1229205010452	catalytic residues [active]
1229205010453	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
1229205010454	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
1229205010455	NADP binding site [chemical binding]; other site
1229205010456	dimer interface [polypeptide binding]; other site
1229205010457	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
1229205010458	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
1229205010459	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1229205010460	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
1229205010461	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
1229205010462	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
1229205010463	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
1229205010464	Ligand Binding Site [chemical binding]; other site
1229205010465	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
1229205010466	GAF domain; Region: GAF_3; pfam13492
1229205010467	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205010468	dimer interface [polypeptide binding]; other site
1229205010469	phosphorylation site [posttranslational modification]
1229205010470	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205010471	ATP binding site [chemical binding]; other site
1229205010472	Mg2+ binding site [ion binding]; other site
1229205010473	G-X-G motif; other site
1229205010474	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
1229205010475	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205010476	active site
1229205010477	phosphorylation site [posttranslational modification]
1229205010478	intermolecular recognition site; other site
1229205010479	dimerization interface [polypeptide binding]; other site
1229205010480	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229205010481	DNA binding site [nucleotide binding]
1229205010482	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
1229205010483	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
1229205010484	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
1229205010485	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
1229205010486	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
1229205010487	apolar tunnel; other site
1229205010488	heme binding site [chemical binding]; other site
1229205010489	dimerization interface [polypeptide binding]; other site
1229205010490	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
1229205010491	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
1229205010492	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
1229205010493	glucose-1-dehydrogenase; Provisional; Region: PRK06947
1229205010494	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205010495	NAD(P) binding site [chemical binding]; other site
1229205010496	active site
1229205010497	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
1229205010498	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229205010499	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229205010500	Bacterial transcriptional repressor; Region: TetR; pfam13972
1229205010501	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
1229205010502	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229205010503	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
1229205010504	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
1229205010505	putative active site [active]
1229205010506	putative metal binding site [ion binding]; other site
1229205010507	RDD family; Region: RDD; pfam06271
1229205010508	Protein of unknown function (DUF3106); Region: DUF3106; pfam11304
1229205010509	Protein of unknown function (DUF3619); Region: DUF3619; pfam12279
1229205010510	RNA polymerase factor sigma-70; Validated; Region: PRK09047
1229205010511	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1229205010512	DNA binding residues [nucleotide binding]
1229205010513	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965
1229205010514	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1229205010515	PYR/PP interface [polypeptide binding]; other site
1229205010516	dimer interface [polypeptide binding]; other site
1229205010517	TPP binding site [chemical binding]; other site
1229205010518	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1229205010519	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1229205010520	TPP-binding site [chemical binding]; other site
1229205010521	dimer interface [polypeptide binding]; other site
1229205010522	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1229205010523	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1229205010524	putative valine binding site [chemical binding]; other site
1229205010525	dimer interface [polypeptide binding]; other site
1229205010526	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1229205010527	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1229205010528	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1229205010529	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1229205010530	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
1229205010531	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
1229205010532	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
1229205010533	2-isopropylmalate synthase; Validated; Region: PRK00915
1229205010534	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
1229205010535	active site
1229205010536	catalytic residues [active]
1229205010537	metal binding site [ion binding]; metal-binding site
1229205010538	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1229205010539	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1229205010540	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1229205010541	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
1229205010542	active site clefts [active]
1229205010543	zinc binding site [ion binding]; other site
1229205010544	dimer interface [polypeptide binding]; other site
1229205010545	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1229205010546	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
1229205010547	putative ligand binding site [chemical binding]; other site
1229205010548	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1229205010549	16S/18S rRNA binding site [nucleotide binding]; other site
1229205010550	S13e-L30e interaction site [polypeptide binding]; other site
1229205010551	25S rRNA binding site [nucleotide binding]; other site
1229205010552	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1229205010553	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
1229205010554	RNase E interface [polypeptide binding]; other site
1229205010555	trimer interface [polypeptide binding]; other site
1229205010556	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1229205010557	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1229205010558	RNase E interface [polypeptide binding]; other site
1229205010559	trimer interface [polypeptide binding]; other site
1229205010560	active site
1229205010561	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1229205010562	putative nucleic acid binding region [nucleotide binding]; other site
1229205010563	G-X-X-G motif; other site
1229205010564	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1229205010565	RNA binding site [nucleotide binding]; other site
1229205010566	domain interface; other site
1229205010567	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
1229205010568	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
1229205010569	NAD(P) binding site [chemical binding]; other site
1229205010570	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1229205010571	dimer interface [polypeptide binding]; other site
1229205010572	substrate binding site [chemical binding]; other site
1229205010573	catalytic triad [active]
1229205010574	Preprotein translocase SecG subunit; Region: SecG; pfam03840
1229205010575	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
1229205010576	NADH dehydrogenase subunit B; Validated; Region: PRK06411
1229205010577	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
1229205010578	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
1229205010579	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
1229205010580	NADH dehydrogenase subunit D; Validated; Region: PRK06075
1229205010581	NADH dehydrogenase subunit E; Validated; Region: PRK07539
1229205010582	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
1229205010583	putative dimer interface [polypeptide binding]; other site
1229205010584	[2Fe-2S] cluster binding site [ion binding]; other site
1229205010585	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
1229205010586	SLBB domain; Region: SLBB; pfam10531
1229205010587	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
1229205010588	NADH dehydrogenase subunit G; Validated; Region: PRK09129
1229205010589	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1229205010590	catalytic loop [active]
1229205010591	iron binding site [ion binding]; other site
1229205010592	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1229205010593	MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772
1229205010594	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
1229205010595	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
1229205010596	4Fe-4S binding domain; Region: Fer4; cl02805
1229205010597	4Fe-4S binding domain; Region: Fer4; pfam00037
1229205010598	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
1229205010599	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
1229205010600	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
1229205010601	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
1229205010602	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
1229205010603	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1229205010604	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
1229205010605	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1229205010606	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
1229205010607	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1229205010608	Protein of unknown function (DUF2818); Region: DUF2818; pfam10993
1229205010609	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
1229205010610	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1229205010611	dimer interface [polypeptide binding]; other site
1229205010612	ADP-ribose binding site [chemical binding]; other site
1229205010613	active site
1229205010614	nudix motif; other site
1229205010615	metal binding site [ion binding]; metal-binding site
1229205010616	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
1229205010617	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
1229205010618	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
1229205010619	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
1229205010620	FAD binding site [chemical binding]; other site
1229205010621	substrate binding site [chemical binding]; other site
1229205010622	catalytic base [active]
1229205010623	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
1229205010624	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1229205010625	active site
1229205010626	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
1229205010627	putative active site [active]
1229205010628	putative catalytic site [active]
1229205010629	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
1229205010630	putative active site [active]
1229205010631	putative catalytic site [active]
1229205010632	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
1229205010633	dimer interface [polypeptide binding]; other site
1229205010634	GSH binding site (G-site) [chemical binding]; other site
1229205010635	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
1229205010636	N-terminal domain interface [polypeptide binding]; other site
1229205010637	putative dimer interface [polypeptide binding]; other site
1229205010638	active site
1229205010639	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1229205010640	Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155
1229205010641	FAD binding site [chemical binding]; other site
1229205010642	substrate binding site [chemical binding]; other site
1229205010643	catalytic base [active]
1229205010644	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
1229205010645	Phosphotransferase enzyme family; Region: APH; pfam01636
1229205010646	putative active site [active]
1229205010647	putative substrate binding site [chemical binding]; other site
1229205010648	ATP binding site [chemical binding]; other site
1229205010649	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1229205010650	catalytic core [active]
1229205010651	enoyl-CoA hydratase; Provisional; Region: PRK07511
1229205010652	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1229205010653	substrate binding site [chemical binding]; other site
1229205010654	oxyanion hole (OAH) forming residues; other site
1229205010655	trimer interface [polypeptide binding]; other site
1229205010656	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
1229205010657	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1229205010658	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1229205010659	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1229205010660	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1229205010661	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
1229205010662	C-terminal domain interface [polypeptide binding]; other site
1229205010663	GSH binding site (G-site) [chemical binding]; other site
1229205010664	dimer interface [polypeptide binding]; other site
1229205010665	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1229205010666	N-terminal domain interface [polypeptide binding]; other site
1229205010667	dimer interface [polypeptide binding]; other site
1229205010668	substrate binding pocket (H-site) [chemical binding]; other site
1229205010669	methionine aminotransferase; Validated; Region: PRK09082
1229205010670	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229205010671	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205010672	homodimer interface [polypeptide binding]; other site
1229205010673	catalytic residue [active]
1229205010674	PIN domain; Region: PIN_3; pfam13470
1229205010675	hypothetical protein; Validated; Region: PRK02101
1229205010676	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
1229205010677	Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234
1229205010678	putative active site [active]
1229205010679	Zn binding site [ion binding]; other site
1229205010680	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
1229205010681	Predicted membrane protein [Function unknown]; Region: COG3235
1229205010682	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1229205010683	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
1229205010684	phosphorylation site [posttranslational modification]
1229205010685	intermolecular recognition site; other site
1229205010686	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1229205010687	DNA binding residues [nucleotide binding]
1229205010688	dimerization interface [polypeptide binding]; other site
1229205010689	Protein of unknown function (DUF2863); Region: DUF2863; pfam11062
1229205010690	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1229205010691	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
1229205010692	Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101
1229205010693	Uncharacterized conserved protein [Function unknown]; Region: COG4544
1229205010694	DNA Polymerase Y-family; Region: PolY_like; cd03468
1229205010695	DNA binding site [nucleotide binding]
1229205010696	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
1229205010697	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
1229205010698	putative active site [active]
1229205010699	putative PHP Thumb interface [polypeptide binding]; other site
1229205010700	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
1229205010701	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1229205010702	generic binding surface II; other site
1229205010703	generic binding surface I; other site
1229205010704	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1229205010705	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
1229205010706	NADP binding site [chemical binding]; other site
1229205010707	active site
1229205010708	putative substrate binding site [chemical binding]; other site
1229205010709	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1229205010710	metal-binding site [ion binding]
1229205010711	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
1229205010712	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
1229205010713	DNA binding residues [nucleotide binding]
1229205010714	dimer interface [polypeptide binding]; other site
1229205010715	copper binding site [ion binding]; other site
1229205010716	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1229205010717	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1229205010718	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
1229205010719	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
1229205010720	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1229205010721	active site
1229205010722	catalytic tetrad [active]
1229205010723	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394
1229205010724	classical (c) SDRs; Region: SDR_c; cd05233
1229205010725	NAD(P) binding site [chemical binding]; other site
1229205010726	active site
1229205010727	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1229205010728	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
1229205010729	nucleophile elbow; other site
1229205010730	Patatin phospholipase; Region: DUF3734; pfam12536
1229205010731	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
1229205010732	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229205010733	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205010734	homodimer interface [polypeptide binding]; other site
1229205010735	catalytic residue [active]
1229205010736	excinuclease ABC subunit B; Provisional; Region: PRK05298
1229205010737	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1229205010738	ATP binding site [chemical binding]; other site
1229205010739	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1229205010740	nucleotide binding region [chemical binding]; other site
1229205010741	ATP-binding site [chemical binding]; other site
1229205010742	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1229205010743	UvrB/uvrC motif; Region: UVR; pfam02151
1229205010744	Fe2+ transport protein; Region: Iron_transport; pfam10634
1229205010745	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
1229205010746	Iron permease FTR1 family; Region: FTR1; cl00475
1229205010747	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
1229205010748	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1229205010749	Hemin uptake protein hemP; Region: hemP; pfam10636
1229205010750	DUF1857, an uncharacterized ligand-binding domain of the SRPBCC domain superfamily; Region: SRPBCC_DUF1857; cd08863
1229205010751	putative hydrophobic ligand binding site [chemical binding]; other site
1229205010752	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
1229205010753	Pirin-related protein [General function prediction only]; Region: COG1741
1229205010754	Pirin; Region: Pirin; pfam02678
1229205010755	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
1229205010756	LysR family transcriptional regulator; Provisional; Region: PRK14997
1229205010757	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205010758	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
1229205010759	putative effector binding pocket; other site
1229205010760	putative dimerization interface [polypeptide binding]; other site
1229205010761	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1229205010762	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
1229205010763	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
1229205010764	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
1229205010765	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1229205010766	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
1229205010767	glutamate racemase; Provisional; Region: PRK00865
1229205010768	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
1229205010769	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
1229205010770	heme binding site [chemical binding]; other site
1229205010771	ferroxidase pore; other site
1229205010772	ferroxidase diiron center [ion binding]; other site
1229205010773	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
1229205010774	Fumarase C-terminus; Region: Fumerase_C; pfam05683
1229205010775	hypothetical protein; Provisional; Region: PRK05208
1229205010776	acetyl-CoA synthetase; Provisional; Region: PRK00174
1229205010777	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
1229205010778	active site
1229205010779	CoA binding site [chemical binding]; other site
1229205010780	acyl-activating enzyme (AAE) consensus motif; other site
1229205010781	AMP binding site [chemical binding]; other site
1229205010782	acetate binding site [chemical binding]; other site
1229205010783	Domain of unknown function (DUF4212); Region: DUF4212; pfam13937
1229205010784	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
1229205010785	Ezrin/radixin/moesin family; Region: ERM; pfam00769
1229205010786	probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648
1229205010787	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1229205010788	MarR family; Region: MarR_2; pfam12802
1229205010789	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1229205010790	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205010791	NAD(P) binding site [chemical binding]; other site
1229205010792	active site
1229205010793	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
1229205010794	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
1229205010795	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1229205010796	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1229205010797	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1229205010798	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205010799	ABC-ATPase subunit interface; other site
1229205010800	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1229205010801	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205010802	dimer interface [polypeptide binding]; other site
1229205010803	conserved gate region; other site
1229205010804	putative PBP binding loops; other site
1229205010805	ABC-ATPase subunit interface; other site
1229205010806	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1229205010807	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1229205010808	Walker A/P-loop; other site
1229205010809	ATP binding site [chemical binding]; other site
1229205010810	Q-loop/lid; other site
1229205010811	ABC transporter signature motif; other site
1229205010812	Walker B; other site
1229205010813	D-loop; other site
1229205010814	H-loop/switch region; other site
1229205010815	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1229205010816	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1229205010817	active site
1229205010818	non-prolyl cis peptide bond; other site
1229205010819	short chain dehydrogenase; Provisional; Region: PRK07577
1229205010820	classical (c) SDRs; Region: SDR_c; cd05233
1229205010821	NAD(P) binding site [chemical binding]; other site
1229205010822	active site
1229205010823	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1229205010824	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1229205010825	BNR repeat-like domain; Region: BNR_2; pfam13088
1229205010826	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
1229205010827	catalytic site [active]
1229205010828	Asp-box motif; other site
1229205010829	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
1229205010830	Na binding site [ion binding]; other site
1229205010831	Protein of unknown function, DUF1537; Region: DUF1537; cl01345
1229205010832	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
1229205010833	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
1229205010834	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
1229205010835	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1229205010836	putative active site [active]
1229205010837	metal binding site [ion binding]; metal-binding site
1229205010838	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1229205010839	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1229205010840	inhibitor site; inhibition site
1229205010841	active site
1229205010842	dimer interface [polypeptide binding]; other site
1229205010843	catalytic residue [active]
1229205010844	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205010845	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205010846	trimer interface [polypeptide binding]; other site
1229205010847	eyelet of channel; other site
1229205010848	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205010849	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205010850	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1229205010851	putative effector binding pocket; other site
1229205010852	dimerization interface [polypeptide binding]; other site
1229205010853	short chain dehydrogenase; Provisional; Region: PRK07478
1229205010854	classical (c) SDRs; Region: SDR_c; cd05233
1229205010855	NAD(P) binding site [chemical binding]; other site
1229205010856	active site
1229205010857	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1229205010858	classical (c) SDRs; Region: SDR_c; cd05233
1229205010859	NAD(P) binding site [chemical binding]; other site
1229205010860	active site
1229205010861	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1229205010862	C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193
1229205010863	putative N-terminal domain interface [polypeptide binding]; other site
1229205010864	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
1229205010865	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1229205010866	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1229205010867	Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979
1229205010868	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
1229205010869	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
1229205010870	Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211
1229205010871	nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888
1229205010872	nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889
1229205010873	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
1229205010874	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1229205010875	active site
1229205010876	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1229205010877	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
1229205010878	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
1229205010879	Flavin binding site [chemical binding]; other site
1229205010880	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
1229205010881	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205010882	Walker A motif; other site
1229205010883	ATP binding site [chemical binding]; other site
1229205010884	Walker B motif; other site
1229205010885	arginine finger; other site
1229205010886	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
1229205010887	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
1229205010888	Flavin binding site [chemical binding]; other site
1229205010889	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1229205010890	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1229205010891	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
1229205010892	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1229205010893	active site
1229205010894	dimer interface [polypeptide binding]; other site
1229205010895	non-prolyl cis peptide bond; other site
1229205010896	insertion regions; other site
1229205010897	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1229205010898	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1229205010899	Walker A/P-loop; other site
1229205010900	ATP binding site [chemical binding]; other site
1229205010901	Q-loop/lid; other site
1229205010902	ABC transporter signature motif; other site
1229205010903	Walker B; other site
1229205010904	D-loop; other site
1229205010905	H-loop/switch region; other site
1229205010906	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1229205010907	TM-ABC transporter signature motif; other site
1229205010908	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1229205010909	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1229205010910	TM-ABC transporter signature motif; other site
1229205010911	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334
1229205010912	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1229205010913	putative ligand binding site [chemical binding]; other site
1229205010914	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1229205010915	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1229205010916	Walker A/P-loop; other site
1229205010917	ATP binding site [chemical binding]; other site
1229205010918	Q-loop/lid; other site
1229205010919	ABC transporter signature motif; other site
1229205010920	Walker B; other site
1229205010921	D-loop; other site
1229205010922	H-loop/switch region; other site
1229205010923	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1229205010924	Beta-lactamase; Region: Beta-lactamase; pfam00144
1229205010925	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1229205010926	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1229205010927	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
1229205010928	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
1229205010929	Clp amino terminal domain; Region: Clp_N; pfam02861
1229205010930	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205010931	Walker A motif; other site
1229205010932	ATP binding site [chemical binding]; other site
1229205010933	Walker B motif; other site
1229205010934	arginine finger; other site
1229205010935	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205010936	Walker A motif; other site
1229205010937	ATP binding site [chemical binding]; other site
1229205010938	Walker B motif; other site
1229205010939	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1229205010940	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
1229205010941	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1229205010942	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1229205010943	ligand binding site [chemical binding]; other site
1229205010944	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
1229205010945	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
1229205010946	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
1229205010947	Protein of unknown function (DUF770); Region: DUF770; pfam05591
1229205010948	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
1229205010949	Protein of unknown function (DUF877); Region: DUF877; pfam05943
1229205010950	Rhs element Vgr protein; Region: vgr_GE; TIGR01646
1229205010951	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
1229205010952	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
1229205010953	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
1229205010954	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
1229205010955	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
1229205010956	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
1229205010957	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
1229205010958	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
1229205010959	type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362
1229205010960	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
1229205010961	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
1229205010962	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
1229205010963	Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790
1229205010964	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
1229205010965	putative FMN binding site [chemical binding]; other site
1229205010966	MbtH-like protein; Region: MbtH; cl01279
1229205010967	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
1229205010968	Cupin domain; Region: Cupin_2; cl17218
1229205010969	YqcI/YcgG family; Region: YqcI_YcgG; cl01349
1229205010970	ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615
1229205010971	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1229205010972	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1229205010973	Walker A/P-loop; other site
1229205010974	ATP binding site [chemical binding]; other site
1229205010975	Q-loop/lid; other site
1229205010976	ABC transporter signature motif; other site
1229205010977	Walker B; other site
1229205010978	D-loop; other site
1229205010979	H-loop/switch region; other site
1229205010980	iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575
1229205010981	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1229205010982	Walker A/P-loop; other site
1229205010983	ATP binding site [chemical binding]; other site
1229205010984	Q-loop/lid; other site
1229205010985	ABC transporter signature motif; other site
1229205010986	Walker B; other site
1229205010987	D-loop; other site
1229205010988	H-loop/switch region; other site
1229205010989	acyl-CoA synthetase; Validated; Region: PRK05850
1229205010990	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1229205010991	acyl-activating enzyme (AAE) consensus motif; other site
1229205010992	active site
1229205010993	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1229205010994	Condensation domain; Region: Condensation; pfam00668
1229205010995	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1229205010996	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1229205010997	Condensation domain; Region: Condensation; pfam00668
1229205010998	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1229205010999	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
1229205011000	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1229205011001	N-terminal plug; other site
1229205011002	ligand-binding site [chemical binding]; other site
1229205011003	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1229205011004	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1229205011005	intersubunit interface [polypeptide binding]; other site
1229205011006	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1229205011007	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1229205011008	ABC-ATPase subunit  interface; other site
1229205011009	dimer interface [polypeptide binding]; other site
1229205011010	putative PBP binding regions; other site
1229205011011	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1229205011012	ABC-ATPase subunit  interface; other site
1229205011013	dimer interface [polypeptide binding]; other site
1229205011014	putative PBP binding regions; other site
1229205011015	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1229205011016	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1229205011017	N-terminal plug; other site
1229205011018	ligand-binding site [chemical binding]; other site
1229205011019	enterobactin exporter EntS; Provisional; Region: PRK10489
1229205011020	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205011021	putative substrate translocation pore; other site
1229205011022	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1229205011023	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
1229205011024	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
1229205011025	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1229205011026	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205011027	active site
1229205011028	phosphorylation site [posttranslational modification]
1229205011029	intermolecular recognition site; other site
1229205011030	dimerization interface [polypeptide binding]; other site
1229205011031	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
1229205011032	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205011033	short chain dehydrogenase; Provisional; Region: PRK12937
1229205011034	NAD(P) binding site [chemical binding]; other site
1229205011035	active site
1229205011036	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205011037	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205011038	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
1229205011039	putative effector binding pocket; other site
1229205011040	putative dimerization interface [polypeptide binding]; other site
1229205011041	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
1229205011042	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1229205011043	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1229205011044	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229205011045	Walker A/P-loop; other site
1229205011046	ATP binding site [chemical binding]; other site
1229205011047	Q-loop/lid; other site
1229205011048	ABC transporter signature motif; other site
1229205011049	Walker B; other site
1229205011050	D-loop; other site
1229205011051	H-loop/switch region; other site
1229205011052	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229205011053	Walker A/P-loop; other site
1229205011054	ATP binding site [chemical binding]; other site
1229205011055	Q-loop/lid; other site
1229205011056	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1229205011057	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1229205011058	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1229205011059	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1229205011060	conserved cys residue [active]
1229205011061	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205011062	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
1229205011063	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
1229205011064	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205011065	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205011066	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205011067	dimerization interface [polypeptide binding]; other site
1229205011068	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1229205011069	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
1229205011070	active site
1229205011071	homodimer interface [polypeptide binding]; other site
1229205011072	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
1229205011073	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
1229205011074	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489
1229205011075	active site
1229205011076	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
1229205011077	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
1229205011078	Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283
1229205011079	Lysine efflux permease [General function prediction only]; Region: COG1279
1229205011080	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
1229205011081	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205011082	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205011083	dimerization interface [polypeptide binding]; other site
1229205011084	putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791
1229205011085	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205011086	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205011087	dimerization interface [polypeptide binding]; other site
1229205011088	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1229205011089	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
1229205011090	metal binding site [ion binding]; metal-binding site
1229205011091	putative dimer interface [polypeptide binding]; other site
1229205011092	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205011093	metabolite-proton symporter; Region: 2A0106; TIGR00883
1229205011094	putative substrate translocation pore; other site
1229205011095	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205011096	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229205011097	putative substrate translocation pore; other site
1229205011098	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1229205011099	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1229205011100	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205011101	NAD(P) binding site [chemical binding]; other site
1229205011102	active site
1229205011103	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205011104	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205011105	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205011106	dimerization interface [polypeptide binding]; other site
1229205011107	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
1229205011108	active sites [active]
1229205011109	tetramer interface [polypeptide binding]; other site
1229205011110	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
1229205011111	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205011112	DNA-binding site [nucleotide binding]; DNA binding site
1229205011113	UTRA domain; Region: UTRA; pfam07702
1229205011114	urocanate hydratase; Provisional; Region: PRK05414
1229205011115	HutD; Region: HutD; pfam05962
1229205011116	imidazolonepropionase; Validated; Region: PRK09356
1229205011117	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
1229205011118	active site
1229205011119	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
1229205011120	Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313
1229205011121	active site
1229205011122	N-formylglutamate amidohydrolase; Region: FGase; cl01522
1229205011123	Mitochondrial fission regulator; Region: Mito_fiss_reg; pfam05308
1229205011124	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
1229205011125	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1229205011126	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1229205011127	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1229205011128	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1229205011129	dimerization interface [polypeptide binding]; other site
1229205011130	ligand binding site [chemical binding]; other site
1229205011131	pyridoxamine kinase; Validated; Region: PRK05756
1229205011132	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
1229205011133	dimer interface [polypeptide binding]; other site
1229205011134	pyridoxal binding site [chemical binding]; other site
1229205011135	ATP binding site [chemical binding]; other site
1229205011136	glycogen synthase; Provisional; Region: glgA; PRK00654
1229205011137	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
1229205011138	ADP-binding pocket [chemical binding]; other site
1229205011139	homodimer interface [polypeptide binding]; other site
1229205011140	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
1229205011141	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1229205011142	ligand binding site; other site
1229205011143	oligomer interface; other site
1229205011144	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1229205011145	dimer interface [polypeptide binding]; other site
1229205011146	N-terminal domain interface [polypeptide binding]; other site
1229205011147	sulfate 1 binding site; other site
1229205011148	Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342
1229205011149	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1229205011150	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1229205011151	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1229205011152	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
1229205011153	Member of the Rhodanese Homology Domain superfamily, repeat 1. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 1st repeat which does not contain the putative...; Region: 4RHOD_Repeat_1; cd01532
1229205011154	active site residue [active]
1229205011155	Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533
1229205011156	active site residue [active]
1229205011157	Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534
1229205011158	active site residue [active]
1229205011159	Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535
1229205011160	active site residue [active]
1229205011161	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
1229205011162	hypothetical protein; Provisional; Region: PRK10279
1229205011163	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
1229205011164	active site
1229205011165	nucleophile elbow; other site
1229205011166	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1229205011167	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205011168	dimer interface [polypeptide binding]; other site
1229205011169	conserved gate region; other site
1229205011170	putative PBP binding loops; other site
1229205011171	ABC-ATPase subunit interface; other site
1229205011172	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1229205011173	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205011174	dimer interface [polypeptide binding]; other site
1229205011175	conserved gate region; other site
1229205011176	putative PBP binding loops; other site
1229205011177	ABC-ATPase subunit interface; other site
1229205011178	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
1229205011179	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1229205011180	Walker A/P-loop; other site
1229205011181	ATP binding site [chemical binding]; other site
1229205011182	Q-loop/lid; other site
1229205011183	ABC transporter signature motif; other site
1229205011184	Walker B; other site
1229205011185	D-loop; other site
1229205011186	H-loop/switch region; other site
1229205011187	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1229205011188	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
1229205011189	conserved cys residue [active]
1229205011190	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205011191	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205011192	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
1229205011193	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1229205011194	inhibitor-cofactor binding pocket; inhibition site
1229205011195	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205011196	catalytic residue [active]
1229205011197	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
1229205011198	Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440
1229205011199	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
1229205011200	Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440
1229205011201	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
1229205011202	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
1229205011203	NAD(P) binding site [chemical binding]; other site
1229205011204	catalytic residues [active]
1229205011205	succinylarginine dihydrolase; Provisional; Region: PRK13281
1229205011206	succinylglutamate desuccinylase; Provisional; Region: PRK05324
1229205011207	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
1229205011208	active site
1229205011209	Zn binding site [ion binding]; other site
1229205011210	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
1229205011211	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229205011212	substrate binding pocket [chemical binding]; other site
1229205011213	membrane-bound complex binding site; other site
1229205011214	hinge residues; other site
1229205011215	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
1229205011216	EAL domain; Region: EAL; pfam00563
1229205011217	HDOD domain; Region: HDOD; pfam08668
1229205011218	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1229205011219	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1229205011220	metal binding site [ion binding]; metal-binding site
1229205011221	active site
1229205011222	I-site; other site
1229205011223	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1229205011224	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
1229205011225	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1229205011226	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1229205011227	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1229205011228	catalytic triad [active]
1229205011229	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
1229205011230	Protein export membrane protein; Region: SecD_SecF; cl14618
1229205011231	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
1229205011232	Protein export membrane protein; Region: SecD_SecF; cl14618
1229205011233	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1229205011234	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1229205011235	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1229205011236	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1229205011237	exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100
1229205011238	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
1229205011239	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
1229205011240	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
1229205011241	Chromate transporter; Region: Chromate_transp; pfam02417
1229205011242	Chromate resistance exported protein; Region: Chrome_Resist; pfam09828
1229205011243	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205011244	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1229205011245	NAD(P) binding site [chemical binding]; other site
1229205011246	active site
1229205011247	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205011248	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205011249	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205011250	dimerization interface [polypeptide binding]; other site
1229205011251	muconolactone delta-isomerase; Region: muco_delta; TIGR03221
1229205011252	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
1229205011253	Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318
1229205011254	octamer interface [polypeptide binding]; other site
1229205011255	active site
1229205011256	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
1229205011257	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205011258	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445
1229205011259	dimerizarion interface [polypeptide binding]; other site
1229205011260	CrgA pocket; other site
1229205011261	substrate binding pocket [chemical binding]; other site
1229205011262	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
1229205011263	Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460
1229205011264	dimer interface [polypeptide binding]; other site
1229205011265	active site
1229205011266	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
1229205011267	Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542
1229205011268	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
1229205011269	putative alpha subunit interface [polypeptide binding]; other site
1229205011270	putative active site [active]
1229205011271	putative substrate binding site [chemical binding]; other site
1229205011272	Fe binding site [ion binding]; other site
1229205011273	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
1229205011274	inter-subunit interface; other site
1229205011275	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
1229205011276	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1229205011277	catalytic loop [active]
1229205011278	iron binding site [ion binding]; other site
1229205011279	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
1229205011280	FAD binding pocket [chemical binding]; other site
1229205011281	FAD binding motif [chemical binding]; other site
1229205011282	phosphate binding motif [ion binding]; other site
1229205011283	beta-alpha-beta structure motif; other site
1229205011284	NAD binding pocket [chemical binding]; other site
1229205011285	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823
1229205011286	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205011287	NAD(P) binding site [chemical binding]; other site
1229205011288	active site
1229205011289	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1229205011290	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1229205011291	putative DNA binding site [nucleotide binding]; other site
1229205011292	putative Zn2+ binding site [ion binding]; other site
1229205011293	AsnC family; Region: AsnC_trans_reg; pfam01037
1229205011294	Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994
1229205011295	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1229205011296	kynureninase; Region: kynureninase; TIGR01814
1229205011297	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1229205011298	catalytic residue [active]
1229205011299	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1229205011300	Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435
1229205011301	Cupin domain; Region: Cupin_2; pfam07883
1229205011302	Cupin domain; Region: Cupin_2; pfam07883
1229205011303	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1229205011304	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1229205011305	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1229205011306	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
1229205011307	putative active site [active]
1229205011308	catalytic triad [active]
1229205011309	putative dimer interface [polypeptide binding]; other site
1229205011310	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
1229205011311	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1229205011312	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205011313	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205011314	trimer interface [polypeptide binding]; other site
1229205011315	eyelet of channel; other site
1229205011316	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
1229205011317	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
1229205011318	PRC-barrel domain; Region: PRC; pfam05239
1229205011319	chromosome condensation membrane protein; Provisional; Region: PRK14196
1229205011320	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1229205011321	CHASE3 domain; Region: CHASE3; pfam05227
1229205011322	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229205011323	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1229205011324	dimer interface [polypeptide binding]; other site
1229205011325	phosphorylation site [posttranslational modification]
1229205011326	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205011327	ATP binding site [chemical binding]; other site
1229205011328	Mg2+ binding site [ion binding]; other site
1229205011329	G-X-G motif; other site
1229205011330	intracellular protease, PfpI family; Region: PfpI; TIGR01382
1229205011331	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
1229205011332	conserved cys residue [active]
1229205011333	Predicted transcriptional regulator [Transcription]; Region: COG1959
1229205011334	Transcriptional regulator; Region: Rrf2; pfam02082
1229205011335	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
1229205011336	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1229205011337	NAD binding site [chemical binding]; other site
1229205011338	substrate binding site [chemical binding]; other site
1229205011339	putative active site [active]
1229205011340	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
1229205011341	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1229205011342	Cysteine dioxygenase type I; Region: CDO_I; pfam05995
1229205011343	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1229205011344	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1229205011345	putative DNA binding site [nucleotide binding]; other site
1229205011346	putative Zn2+ binding site [ion binding]; other site
1229205011347	AsnC family; Region: AsnC_trans_reg; pfam01037
1229205011348	Protein of unknown function (DUF1326); Region: DUF1326; cl02375
1229205011349	Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948
1229205011350	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
1229205011351	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1229205011352	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
1229205011353	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
1229205011354	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
1229205011355	Family description; Region: UvrD_C_2; pfam13538
1229205011356	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1229205011357	AAA domain; Region: AAA_30; pfam13604
1229205011358	Family description; Region: UvrD_C_2; pfam13538
1229205011359	hypothetical protein; Provisional; Region: PRK09256
1229205011360	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
1229205011361	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1229205011362	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1229205011363	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1229205011364	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1229205011365	putative active site [active]
1229205011366	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1229205011367	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205011368	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205011369	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
1229205011370	putative dimerization interface [polypeptide binding]; other site
1229205011371	aspartate aminotransferase; Provisional; Region: PRK06108
1229205011372	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229205011373	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205011374	homodimer interface [polypeptide binding]; other site
1229205011375	catalytic residue [active]
1229205011376	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
1229205011377	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1229205011378	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1229205011379	RNA binding surface [nucleotide binding]; other site
1229205011380	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
1229205011381	probable active site [active]
1229205011382	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1229205011383	Sm and related proteins; Region: Sm_like; cl00259
1229205011384	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1229205011385	putative oligomer interface [polypeptide binding]; other site
1229205011386	putative RNA binding site [nucleotide binding]; other site
1229205011387	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
1229205011388	NusA N-terminal domain; Region: NusA_N; pfam08529
1229205011389	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1229205011390	RNA binding site [nucleotide binding]; other site
1229205011391	homodimer interface [polypeptide binding]; other site
1229205011392	NusA-like KH domain; Region: KH_5; pfam13184
1229205011393	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1229205011394	G-X-X-G motif; other site
1229205011395	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
1229205011396	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
1229205011397	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
1229205011398	translation initiation factor IF-2; Region: IF-2; TIGR00487
1229205011399	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1229205011400	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1229205011401	G1 box; other site
1229205011402	putative GEF interaction site [polypeptide binding]; other site
1229205011403	GTP/Mg2+ binding site [chemical binding]; other site
1229205011404	Switch I region; other site
1229205011405	G2 box; other site
1229205011406	G3 box; other site
1229205011407	Switch II region; other site
1229205011408	G4 box; other site
1229205011409	G5 box; other site
1229205011410	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1229205011411	Translation-initiation factor 2; Region: IF-2; pfam11987
1229205011412	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1229205011413	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1229205011414	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851
1229205011415	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1229205011416	RNA binding site [nucleotide binding]; other site
1229205011417	active site
1229205011418	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
1229205011419	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1229205011420	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205011421	putative substrate translocation pore; other site
1229205011422	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205011423	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
1229205011424	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1229205011425	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1229205011426	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1229205011427	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1229205011428	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1229205011429	putative DNA binding site [nucleotide binding]; other site
1229205011430	putative Zn2+ binding site [ion binding]; other site
1229205011431	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1229205011432	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1229205011433	G1 box; other site
1229205011434	putative GEF interaction site [polypeptide binding]; other site
1229205011435	GTP/Mg2+ binding site [chemical binding]; other site
1229205011436	Switch I region; other site
1229205011437	G2 box; other site
1229205011438	G3 box; other site
1229205011439	Switch II region; other site
1229205011440	G4 box; other site
1229205011441	G5 box; other site
1229205011442	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1229205011443	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1229205011444	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
1229205011445	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
1229205011446	TPP-binding site [chemical binding]; other site
1229205011447	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1229205011448	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
1229205011449	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1229205011450	E3 interaction surface; other site
1229205011451	lipoyl attachment site [posttranslational modification]; other site
1229205011452	e3 binding domain; Region: E3_binding; pfam02817
1229205011453	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1229205011454	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
1229205011455	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1229205011456	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1229205011457	Predicted ATPase [General function prediction only]; Region: COG1485
1229205011458	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229205011459	Walker B; other site
1229205011460	D-loop; other site
1229205011461	H-loop/switch region; other site
1229205011462	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1229205011463	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
1229205011464	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
1229205011465	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
1229205011466	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
1229205011467	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
1229205011468	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
1229205011469	TadE-like protein; Region: TadE; pfam07811
1229205011470	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
1229205011471	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
1229205011472	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
1229205011473	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
1229205011474	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1229205011475	AAA domain; Region: AAA_31; pfam13614
1229205011476	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1229205011477	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
1229205011478	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1229205011479	ATP binding site [chemical binding]; other site
1229205011480	Walker A motif; other site
1229205011481	hexamer interface [polypeptide binding]; other site
1229205011482	Walker B motif; other site
1229205011483	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
1229205011484	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1229205011485	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
1229205011486	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1229205011487	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1229205011488	binding surface
1229205011489	TPR motif; other site
1229205011490	Protein of unknown function (DUF3613); Region: DUF3613; pfam12266
1229205011491	Predicted membrane protein [Function unknown]; Region: COG4655
1229205011492	Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977
1229205011493	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
1229205011494	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205011495	Walker A motif; other site
1229205011496	ATP binding site [chemical binding]; other site
1229205011497	Walker B motif; other site
1229205011498	arginine finger; other site
1229205011499	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1229205011500	Protein of unknown function (DUF2968); Region: DUF2968; pfam11180
1229205011501	bacterial Hfq-like; Region: Hfq; cd01716
1229205011502	hexamer interface [polypeptide binding]; other site
1229205011503	Sm1 motif; other site
1229205011504	RNA binding site [nucleotide binding]; other site
1229205011505	Sm2 motif; other site
1229205011506	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1229205011507	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1229205011508	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1229205011509	DNA binding residues [nucleotide binding]
1229205011510	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
1229205011511	Pleckstrin homology-like domain; Region: PH-like; cl17171
1229205011512	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1229205011513	FAD binding domain; Region: FAD_binding_4; pfam01565
1229205011514	Protein of unknown function (DUF1571); Region: DUF1571; pfam07608
1229205011515	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
1229205011516	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1229205011517	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1229205011518	acyl-activating enzyme (AAE) consensus motif; other site
1229205011519	putative AMP binding site [chemical binding]; other site
1229205011520	putative active site [active]
1229205011521	putative CoA binding site [chemical binding]; other site
1229205011522	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
1229205011523	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1229205011524	dimer interface [polypeptide binding]; other site
1229205011525	active site
1229205011526	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1229205011527	active site 2 [active]
1229205011528	active site 1 [active]
1229205011529	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
1229205011530	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205011531	NAD(P) binding site [chemical binding]; other site
1229205011532	active site
1229205011533	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
1229205011534	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1229205011535	active site
1229205011536	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
1229205011537	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229205011538	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229205011539	putative sialic acid transporter; Region: 2A0112; TIGR00891
1229205011540	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205011541	putative substrate translocation pore; other site
1229205011542	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205011543	active site
1229205011544	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229205011545	phosphorylation site [posttranslational modification]
1229205011546	intermolecular recognition site; other site
1229205011547	dimerization interface [polypeptide binding]; other site
1229205011548	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205011549	dimer interface [polypeptide binding]; other site
1229205011550	phosphorylation site [posttranslational modification]
1229205011551	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205011552	ATP binding site [chemical binding]; other site
1229205011553	Mg2+ binding site [ion binding]; other site
1229205011554	G-X-G motif; other site
1229205011555	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229205011556	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205011557	ATP binding site [chemical binding]; other site
1229205011558	Mg2+ binding site [ion binding]; other site
1229205011559	G-X-G motif; other site
1229205011560	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1229205011561	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205011562	active site
1229205011563	phosphorylation site [posttranslational modification]
1229205011564	intermolecular recognition site; other site
1229205011565	dimerization interface [polypeptide binding]; other site
1229205011566	Response regulator receiver domain; Region: Response_reg; pfam00072
1229205011567	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205011568	active site
1229205011569	phosphorylation site [posttranslational modification]
1229205011570	intermolecular recognition site; other site
1229205011571	dimerization interface [polypeptide binding]; other site
1229205011572	Predicted dehydrogenase [General function prediction only]; Region: COG5322
1229205011573	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
1229205011574	NAD(P) binding pocket [chemical binding]; other site
1229205011575	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
1229205011576	dimerization interface [polypeptide binding]; other site
1229205011577	Outer membrane efflux protein; Region: OEP; pfam02321
1229205011578	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
1229205011579	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1229205011580	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1229205011581	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
1229205011582	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
1229205011583	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
1229205011584	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1229205011585	Moco binding site; other site
1229205011586	metal coordination site [ion binding]; other site
1229205011587	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
1229205011588	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1229205011589	HAMP domain; Region: HAMP; pfam00672
1229205011590	dimerization interface [polypeptide binding]; other site
1229205011591	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1229205011592	dimer interface [polypeptide binding]; other site
1229205011593	putative CheW interface [polypeptide binding]; other site
1229205011594	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1229205011595	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
1229205011596	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
1229205011597	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
1229205011598	Chromate transporter; Region: Chromate_transp; pfam02417
1229205011599	Domain of unknown function (DUF4130; Region: DUF4130; pfam13566
1229205011600	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
1229205011601	Fe-S cluster binding site [ion binding]; other site
1229205011602	active site
1229205011603	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
1229205011604	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1229205011605	FeS/SAM binding site; other site
1229205011606	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
1229205011607	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1229205011608	Domain of unknown function (DUF1992); Region: DUF1992; pfam09350
1229205011609	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1229205011610	nucleoside/Zn binding site; other site
1229205011611	dimer interface [polypeptide binding]; other site
1229205011612	catalytic motif [active]
1229205011613	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
1229205011614	dimer interface [polypeptide binding]; other site
1229205011615	catalytic triad [active]
1229205011616	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1229205011617	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205011618	DNA-binding site [nucleotide binding]; DNA binding site
1229205011619	FCD domain; Region: FCD; pfam07729
1229205011620	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
1229205011621	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
1229205011622	Na binding site [ion binding]; other site
1229205011623	putative substrate binding site [chemical binding]; other site
1229205011624	Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126
1229205011625	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
1229205011626	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
1229205011627	active site
1229205011628	catalytic site [active]
1229205011629	tetramer interface [polypeptide binding]; other site
1229205011630	OHCU decarboxylase; Region: UHCUDC; TIGR03164
1229205011631	allantoicase; Provisional; Region: PRK13257
1229205011632	Allantoicase repeat; Region: Allantoicase; pfam03561
1229205011633	Allantoicase repeat; Region: Allantoicase; pfam03561
1229205011634	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
1229205011635	ureidoglycolate hydrolase; Provisional; Region: PRK03606
1229205011636	Predicted membrane protein [Function unknown]; Region: COG3748
1229205011637	Protein of unknown function (DUF989); Region: DUF989; pfam06181
1229205011638	Cytochrome c; Region: Cytochrom_C; pfam00034
1229205011639	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
1229205011640	active site
1229205011641	homotetramer interface [polypeptide binding]; other site
1229205011642	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
1229205011643	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
1229205011644	active site
1229205011645	putative substrate binding pocket [chemical binding]; other site
1229205011646	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205011647	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205011648	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_4; cd08463
1229205011649	putative substrate binding pocket [chemical binding]; other site
1229205011650	putative dimerization interface [polypeptide binding]; other site
1229205011651	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
1229205011652	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1229205011653	Walker A/P-loop; other site
1229205011654	ATP binding site [chemical binding]; other site
1229205011655	Q-loop/lid; other site
1229205011656	ABC transporter signature motif; other site
1229205011657	Walker B; other site
1229205011658	D-loop; other site
1229205011659	H-loop/switch region; other site
1229205011660	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1229205011661	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1229205011662	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1229205011663	TM-ABC transporter signature motif; other site
1229205011664	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1229205011665	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1229205011666	TM-ABC transporter signature motif; other site
1229205011667	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
1229205011668	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
1229205011669	putative ligand binding site [chemical binding]; other site
1229205011670	Dodecin; Region: Dodecin; pfam07311
1229205011671	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1229205011672	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1229205011673	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1229205011674	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
1229205011675	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1229205011676	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1229205011677	ABC transporter; Region: ABC_tran_2; pfam12848
1229205011678	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1229205011679	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
1229205011680	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1229205011681	NAD binding site [chemical binding]; other site
1229205011682	catalytic residues [active]
1229205011683	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
1229205011684	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1229205011685	FMN binding site [chemical binding]; other site
1229205011686	substrate binding site [chemical binding]; other site
1229205011687	putative catalytic residue [active]
1229205011688	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
1229205011689	Predicted Fe-S protein [General function prediction only]; Region: COG3313
1229205011690	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
1229205011691	dimerization interface [polypeptide binding]; other site
1229205011692	substrate binding site [chemical binding]; other site
1229205011693	active site
1229205011694	calcium binding site [ion binding]; other site
1229205011695	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
1229205011696	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1229205011697	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
1229205011698	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1229205011699	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
1229205011700	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229205011701	Walker A/P-loop; other site
1229205011702	ATP binding site [chemical binding]; other site
1229205011703	Q-loop/lid; other site
1229205011704	ABC transporter signature motif; other site
1229205011705	Walker B; other site
1229205011706	D-loop; other site
1229205011707	H-loop/switch region; other site
1229205011708	TOBE domain; Region: TOBE_2; pfam08402
1229205011709	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205011710	dimer interface [polypeptide binding]; other site
1229205011711	conserved gate region; other site
1229205011712	putative PBP binding loops; other site
1229205011713	ABC-ATPase subunit interface; other site
1229205011714	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1229205011715	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205011716	dimer interface [polypeptide binding]; other site
1229205011717	conserved gate region; other site
1229205011718	putative PBP binding loops; other site
1229205011719	ABC-ATPase subunit interface; other site
1229205011720	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1229205011721	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1229205011722	dimer interface [polypeptide binding]; other site
1229205011723	putative CheW interface [polypeptide binding]; other site
1229205011724	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1229205011725	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1229205011726	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1229205011727	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
1229205011728	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229205011729	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1229205011730	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229205011731	TPR motif; other site
1229205011732	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
1229205011733	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
1229205011734	Transglycosylase; Region: Transgly; pfam00912
1229205011735	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1229205011736	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1229205011737	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1229205011738	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1229205011739	HlyD family secretion protein; Region: HlyD_3; pfam13437
1229205011740	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229205011741	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229205011742	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1229205011743	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205011744	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205011745	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1229205011746	putative effector binding pocket; other site
1229205011747	dimerization interface [polypeptide binding]; other site
1229205011748	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
1229205011749	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1229205011750	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1229205011751	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
1229205011752	Phospholipase B; Region: Phospholip_B; pfam04916
1229205011753	putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862
1229205011754	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
1229205011755	Cl- selectivity filter; other site
1229205011756	Cl- binding residues [ion binding]; other site
1229205011757	pore gating glutamate residue; other site
1229205011758	dimer interface [polypeptide binding]; other site
1229205011759	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1229205011760	glutathione s-transferase; Provisional; Region: PTZ00057
1229205011761	GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039
1229205011762	GSH binding site (G-site) [chemical binding]; other site
1229205011763	C-terminal domain interface [polypeptide binding]; other site
1229205011764	dimer interface [polypeptide binding]; other site
1229205011765	C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192
1229205011766	dimer interface [polypeptide binding]; other site
1229205011767	N-terminal domain interface [polypeptide binding]; other site
1229205011768	substrate binding pocket (H-site) [chemical binding]; other site
1229205011769	Predicted membrane protein [Function unknown]; Region: COG2855
1229205011770	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205011771	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205011772	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
1229205011773	putative dimerization interface [polypeptide binding]; other site
1229205011774	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1229205011775	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1229205011776	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1229205011777	substrate binding site [chemical binding]; other site
1229205011778	ATP binding site [chemical binding]; other site
1229205011779	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205011780	D-galactonate transporter; Region: 2A0114; TIGR00893
1229205011781	putative substrate translocation pore; other site
1229205011782	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
1229205011783	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
1229205011784	dimerization interface [polypeptide binding]; other site
1229205011785	ligand binding site [chemical binding]; other site
1229205011786	NADP binding site [chemical binding]; other site
1229205011787	catalytic site [active]
1229205011788	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1229205011789	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1229205011790	DNA binding site [nucleotide binding]
1229205011791	domain linker motif; other site
1229205011792	Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283
1229205011793	putative dimerization interface [polypeptide binding]; other site
1229205011794	putative ligand binding site [chemical binding]; other site
1229205011795	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1229205011796	Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086
1229205011797	Protein of unknown function (DUF3022); Region: DUF3022; pfam11226
1229205011798	PGDYG protein; Region: PGDYG; pfam14083
1229205011799	LTXXQ motif family protein; Region: LTXXQ; pfam07813
1229205011800	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205011801	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205011802	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477
1229205011803	putative effector binding pocket; other site
1229205011804	putative dimerization interface [polypeptide binding]; other site
1229205011805	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1229205011806	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1229205011807	AsnC family; Region: AsnC_trans_reg; pfam01037
1229205011808	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
1229205011809	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1229205011810	AAA domain; Region: AAA_33; pfam13671
1229205011811	AAA domain; Region: AAA_17; pfam13207
1229205011812	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1229205011813	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
1229205011814	oligomer interface [polypeptide binding]; other site
1229205011815	metal binding site [ion binding]; metal-binding site
1229205011816	metal binding site [ion binding]; metal-binding site
1229205011817	putative Cl binding site [ion binding]; other site
1229205011818	basic sphincter; other site
1229205011819	hydrophobic gate; other site
1229205011820	periplasmic entrance; other site
1229205011821	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
1229205011822	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1229205011823	ligand binding site [chemical binding]; other site
1229205011824	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1229205011825	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1229205011826	Walker A/P-loop; other site
1229205011827	ATP binding site [chemical binding]; other site
1229205011828	Q-loop/lid; other site
1229205011829	ABC transporter signature motif; other site
1229205011830	Walker B; other site
1229205011831	D-loop; other site
1229205011832	H-loop/switch region; other site
1229205011833	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1229205011834	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
1229205011835	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1229205011836	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1229205011837	TM-ABC transporter signature motif; other site
1229205011838	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1229205011839	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1229205011840	DNA binding site [nucleotide binding]
1229205011841	domain linker motif; other site
1229205011842	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1229205011843	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1229205011844	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1229205011845	substrate binding site [chemical binding]; other site
1229205011846	dimer interface [polypeptide binding]; other site
1229205011847	ATP binding site [chemical binding]; other site
1229205011848	Tar ligand binding domain homologue; Region: TarH; pfam02203
1229205011849	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1229205011850	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1229205011851	dimerization interface [polypeptide binding]; other site
1229205011852	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1229205011853	dimer interface [polypeptide binding]; other site
1229205011854	putative CheW interface [polypeptide binding]; other site
1229205011855	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
1229205011856	PrkA family serine protein kinase; Provisional; Region: PRK15455
1229205011857	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1229205011858	Walker A motif; other site
1229205011859	ATP binding site [chemical binding]; other site
1229205011860	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
1229205011861	hypothetical protein; Provisional; Region: PRK05325
1229205011862	SpoVR family protein; Provisional; Region: PRK11767
1229205011863	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
1229205011864	Protein of unknown function (DUF3620); Region: DUF3620; cl02233
1229205011865	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
1229205011866	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205011867	putative substrate translocation pore; other site
1229205011868	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1229205011869	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1229205011870	active site
1229205011871	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205011872	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205011873	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1229205011874	putative effector binding pocket; other site
1229205011875	dimerization interface [polypeptide binding]; other site
1229205011876	putative transporter; Provisional; Region: PRK10504
1229205011877	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205011878	putative substrate translocation pore; other site
1229205011879	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1229205011880	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1229205011881	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1229205011882	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1229205011883	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1229205011884	Cytochrome c; Region: Cytochrom_C; pfam00034
1229205011885	Predicted membrane protein [Function unknown]; Region: COG2323
1229205011886	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205011887	putative transporter; Provisional; Region: PRK10504
1229205011888	putative substrate translocation pore; other site
1229205011889	Predicted integral membrane protein [Function unknown]; Region: COG0392
1229205011890	Uncharacterized conserved protein [Function unknown]; Region: COG2898
1229205011891	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1229205011892	Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946
1229205011893	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
1229205011894	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
1229205011895	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1229205011896	AMP-binding enzyme; Region: AMP-binding; pfam00501
1229205011897	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
1229205011898	acyl-activating enzyme (AAE) consensus motif; other site
1229205011899	AMP binding site [chemical binding]; other site
1229205011900	acyl carrier protein; Provisional; Region: PRK07081
1229205011901	exosortase A system-associated hydrolase 2; Region: hydr2_PEP; TIGR03101
1229205011902	exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100
1229205011903	threonine dehydratase; Reviewed; Region: PRK09224
1229205011904	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1229205011905	tetramer interface [polypeptide binding]; other site
1229205011906	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205011907	catalytic residue [active]
1229205011908	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
1229205011909	putative Ile/Val binding site [chemical binding]; other site
1229205011910	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
1229205011911	putative Ile/Val binding site [chemical binding]; other site
1229205011912	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
1229205011913	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1229205011914	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
1229205011915	DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090
1229205011916	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1229205011917	dimerization interface [polypeptide binding]; other site
1229205011918	putative Zn2+ binding site [ion binding]; other site
1229205011919	putative DNA binding site [nucleotide binding]; other site
1229205011920	Bacterial transcriptional regulator; Region: IclR; pfam01614
1229205011921	2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832
1229205011922	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
1229205011923	NADP binding site [chemical binding]; other site
1229205011924	homodimer interface [polypeptide binding]; other site
1229205011925	active site
1229205011926	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
1229205011927	2-keto-3-deoxygluconate permease; Region: KdgT; cl14653
1229205011928	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1229205011929	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1229205011930	tetramerization interface [polypeptide binding]; other site
1229205011931	NAD(P) binding site [chemical binding]; other site
1229205011932	catalytic residues [active]
1229205011933	hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471
1229205011934	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
1229205011935	B12 binding site [chemical binding]; other site
1229205011936	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1229205011937	FeS/SAM binding site; other site
1229205011938	hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472
1229205011939	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
1229205011940	ligand binding site; other site
1229205011941	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
1229205011942	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205011943	dimer interface [polypeptide binding]; other site
1229205011944	phosphorylation site [posttranslational modification]
1229205011945	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205011946	ATP binding site [chemical binding]; other site
1229205011947	Mg2+ binding site [ion binding]; other site
1229205011948	G-X-G motif; other site
1229205011949	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1229205011950	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205011951	active site
1229205011952	phosphorylation site [posttranslational modification]
1229205011953	intermolecular recognition site; other site
1229205011954	dimerization interface [polypeptide binding]; other site
1229205011955	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229205011956	DNA binding site [nucleotide binding]
1229205011957	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
1229205011958	ligand binding site; other site
1229205011959	Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506
1229205011960	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
1229205011961	Activator of osmoprotectant transporter ProP [Signal transduction mechanisms]; Region: ProQ; COG3109
1229205011962	ProQ/FINO family; Region: ProQ; pfam04352
1229205011963	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
1229205011964	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1229205011965	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205011966	NAD(P) binding site [chemical binding]; other site
1229205011967	active site
1229205011968	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
1229205011969	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205011970	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1229205011971	dimerization interface [polypeptide binding]; other site
1229205011972	2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479
1229205011973	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1229205011974	catalytic residue [active]
1229205011975	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
1229205011976	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1229205011977	active site
1229205011978	motif I; other site
1229205011979	motif II; other site
1229205011980	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1229205011981	nucleotide binding site [chemical binding]; other site
1229205011982	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
1229205011983	nucleotide binding site [chemical binding]; other site
1229205011984	putative NEF/HSP70 interaction site [polypeptide binding]; other site
1229205011985	SBD interface [polypeptide binding]; other site
1229205011986	DNA-K related protein; Region: DUF3731; pfam12531
1229205011987	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
1229205011988	nucleotide binding site [chemical binding]; other site
1229205011989	putative NEF/HSP70 interaction site [polypeptide binding]; other site
1229205011990	SBD interface [polypeptide binding]; other site
1229205011991	Domain of unknown function (DUF2760); Region: DUF2760; pfam10816
1229205011992	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1229205011993	intersubunit interface [polypeptide binding]; other site
1229205011994	active site
1229205011995	catalytic residue [active]
1229205011996	Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111
1229205011997	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1229205011998	NAD(P) binding site [chemical binding]; other site
1229205011999	catalytic residues [active]
1229205012000	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1229205012001	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1229205012002	NAD(P) binding site [chemical binding]; other site
1229205012003	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1229205012004	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1229205012005	substrate binding site [chemical binding]; other site
1229205012006	dimer interface [polypeptide binding]; other site
1229205012007	ATP binding site [chemical binding]; other site
1229205012008	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1229205012009	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1229205012010	TM-ABC transporter signature motif; other site
1229205012011	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
1229205012012	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1229205012013	ligand binding site [chemical binding]; other site
1229205012014	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1229205012015	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229205012016	Walker A/P-loop; other site
1229205012017	ATP binding site [chemical binding]; other site
1229205012018	Q-loop/lid; other site
1229205012019	ABC transporter signature motif; other site
1229205012020	Walker B; other site
1229205012021	D-loop; other site
1229205012022	H-loop/switch region; other site
1229205012023	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1229205012024	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1229205012025	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1229205012026	TM-ABC transporter signature motif; other site
1229205012027	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1229205012028	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1229205012029	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1229205012030	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
1229205012031	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
1229205012032	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229205012033	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
1229205012034	putative ADP-binding pocket [chemical binding]; other site
1229205012035	phosphoglycolate phosphatase, TA0175-type; Region: Pglycolate_arch; TIGR01487
1229205012036	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1229205012037	active site
1229205012038	motif I; other site
1229205012039	motif II; other site
1229205012040	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1229205012041	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1229205012042	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1229205012043	ATP binding site [chemical binding]; other site
1229205012044	putative Mg++ binding site [ion binding]; other site
1229205012045	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1229205012046	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229205012047	DNA binding site [nucleotide binding]
1229205012048	Predicted ATPase [General function prediction only]; Region: COG3903
1229205012049	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205012050	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1229205012051	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205012052	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1229205012053	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1229205012054	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1229205012055	Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480
1229205012056	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
1229205012057	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
1229205012058	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
1229205012059	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
1229205012060	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
1229205012061	Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812
1229205012062	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
1229205012063	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
1229205012064	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1229205012065	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1229205012066	active site
1229205012067	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1229205012068	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1229205012069	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1229205012070	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1229205012071	ligand binding site [chemical binding]; other site
1229205012072	flexible hinge region; other site
1229205012073	Protein of unknown function (DUF1427); Region: DUF1427; pfam07235
1229205012074	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
1229205012075	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1229205012076	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1229205012077	ligand binding site [chemical binding]; other site
1229205012078	flexible hinge region; other site
1229205012079	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1229205012080	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1229205012081	Domain of unknown function (DUF3331); Region: DUF3331; pfam11811
1229205012082	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1229205012083	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229205012084	DNA binding site [nucleotide binding]
1229205012085	Predicted ATPase [General function prediction only]; Region: COG3903
1229205012086	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
1229205012087	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205012088	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205012089	dimerization interface [polypeptide binding]; other site
1229205012090	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
1229205012091	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
1229205012092	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205012093	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205012094	dimerization interface [polypeptide binding]; other site
1229205012095	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1229205012096	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
1229205012097	putative ligand binding site [chemical binding]; other site
1229205012098	NAD binding site [chemical binding]; other site
1229205012099	catalytic site [active]
1229205012100	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205012101	D-galactonate transporter; Region: 2A0114; TIGR00893
1229205012102	putative substrate translocation pore; other site
1229205012103	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205012104	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
1229205012105	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
1229205012106	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205012107	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205012108	dimerization interface [polypeptide binding]; other site
1229205012109	putative aminotransferase; Validated; Region: PRK07480
1229205012110	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1229205012111	inhibitor-cofactor binding pocket; inhibition site
1229205012112	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205012113	catalytic residue [active]
1229205012114	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1229205012115	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1229205012116	Peptidase C26; Region: Peptidase_C26; pfam07722
1229205012117	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
1229205012118	catalytic triad [active]
1229205012119	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
1229205012120	trimer interface [polypeptide binding]; other site
1229205012121	active site
1229205012122	substrate binding site [chemical binding]; other site
1229205012123	CoA binding site [chemical binding]; other site
1229205012124	Domain of unknown function (DUF1924); Region: DUF1924; pfam09086
1229205012125	Dihaem cytochrome c; Region: DHC; pfam09626
1229205012126	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
1229205012127	DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336
1229205012128	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205012129	active site
1229205012130	phosphorylation site [posttranslational modification]
1229205012131	intermolecular recognition site; other site
1229205012132	dimerization interface [polypeptide binding]; other site
1229205012133	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229205012134	DNA binding site [nucleotide binding]
1229205012135	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205012136	dimer interface [polypeptide binding]; other site
1229205012137	phosphorylation site [posttranslational modification]
1229205012138	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205012139	ATP binding site [chemical binding]; other site
1229205012140	Mg2+ binding site [ion binding]; other site
1229205012141	G-X-G motif; other site
1229205012142	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1229205012143	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1229205012144	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1229205012145	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1229205012146	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205012147	putative substrate translocation pore; other site
1229205012148	Transglycosylase; Region: Transgly; pfam00912
1229205012149	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1229205012150	trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656
1229205012151	NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242
1229205012152	Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241
1229205012153	Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055
1229205012154	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1229205012155	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
1229205012156	putative C-terminal domain interface [polypeptide binding]; other site
1229205012157	putative GSH binding site (G-site) [chemical binding]; other site
1229205012158	putative dimer interface [polypeptide binding]; other site
1229205012159	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
1229205012160	putative N-terminal domain interface [polypeptide binding]; other site
1229205012161	putative dimer interface [polypeptide binding]; other site
1229205012162	putative substrate binding pocket (H-site) [chemical binding]; other site
1229205012163	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1229205012164	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205012165	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1229205012166	dimerization interface [polypeptide binding]; other site
1229205012167	substrate binding pocket [chemical binding]; other site
1229205012168	choline dehydrogenase; Validated; Region: PRK02106
1229205012169	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1229205012170	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1229205012171	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
1229205012172	active site pocket [active]
1229205012173	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205012174	Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088
1229205012175	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1229205012176	NAD binding site [chemical binding]; other site
1229205012177	catalytic residues [active]
1229205012178	substrate binding site [chemical binding]; other site
1229205012179	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
1229205012180	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
1229205012181	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205012182	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1229205012183	active site
1229205012184	SAM binding site [chemical binding]; other site
1229205012185	homodimer interface [polypeptide binding]; other site
1229205012186	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
1229205012187	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
1229205012188	MOSC domain; Region: MOSC; pfam03473
1229205012189	Domain of unknown function (DUF336); Region: DUF336; cl01249
1229205012190	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
1229205012191	active site
1229205012192	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1229205012193	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1229205012194	active site
1229205012195	tetramer interface; other site
1229205012196	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1229205012197	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229205012198	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
1229205012199	putative ADP-binding pocket [chemical binding]; other site
1229205012200	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229205012201	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1229205012202	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1229205012203	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
1229205012204	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1229205012205	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
1229205012206	active site
1229205012207	catalytic triad [active]
1229205012208	oxyanion hole [active]
1229205012209	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
1229205012210	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
1229205012211	NADP-binding site; other site
1229205012212	homotetramer interface [polypeptide binding]; other site
1229205012213	substrate binding site [chemical binding]; other site
1229205012214	homodimer interface [polypeptide binding]; other site
1229205012215	active site
1229205012216	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229205012217	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1229205012218	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
1229205012219	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1229205012220	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1229205012221	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229205012222	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1229205012223	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1229205012224	DXD motif; other site
1229205012225	tyrosine kinase; Provisional; Region: PRK11519
1229205012226	Chain length determinant protein; Region: Wzz; cl15801
1229205012227	Chain length determinant protein; Region: Wzz; cl15801
1229205012228	Angiomotin C terminal; Region: Angiomotin_C; pfam12240
1229205012229	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
1229205012230	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1229205012231	P-loop; other site
1229205012232	Magnesium ion binding site [ion binding]; other site
1229205012233	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
1229205012234	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
1229205012235	SLBB domain; Region: SLBB; pfam10531
1229205012236	SLBB domain; Region: SLBB; pfam10531
1229205012237	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1229205012238	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
1229205012239	active site
1229205012240	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1229205012241	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1229205012242	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1229205012243	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1229205012244	CoA-binding domain; Region: CoA_binding_3; pfam13727
1229205012245	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1229205012246	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
1229205012247	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
1229205012248	Substrate binding site; other site
1229205012249	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
1229205012250	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1229205012251	YciI-like protein; Reviewed; Region: PRK12866
1229205012252	psiF repeat; Region: PsiF_repeat; pfam07769
1229205012253	psiF repeat; Region: PsiF_repeat; pfam07769
1229205012254	Domain of unknown function DUF221; Region: DUF221; pfam02714
1229205012255	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
1229205012256	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
1229205012257	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229205012258	putative ADP-binding pocket [chemical binding]; other site
1229205012259	Predicted ATPase [General function prediction only]; Region: COG4637
1229205012260	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229205012261	Walker A/P-loop; other site
1229205012262	ATP binding site [chemical binding]; other site
1229205012263	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
1229205012264	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
1229205012265	active site
1229205012266	homotetramer interface [polypeptide binding]; other site
1229205012267	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1229205012268	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1229205012269	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1229205012270	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1229205012271	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1229205012272	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1229205012273	active site
1229205012274	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1229205012275	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1229205012276	Coenzyme A binding pocket [chemical binding]; other site
1229205012277	DNA polymerase III subunit delta'; Validated; Region: PRK06964
1229205012278	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1229205012279	thymidylate kinase; Validated; Region: tmk; PRK00698
1229205012280	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1229205012281	TMP-binding site; other site
1229205012282	ATP-binding site [chemical binding]; other site
1229205012283	YceG-like family; Region: YceG; pfam02618
1229205012284	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1229205012285	dimerization interface [polypeptide binding]; other site
1229205012286	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
1229205012287	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
1229205012288	NRDE protein; Region: NRDE; cl01315
1229205012289	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1229205012290	hypothetical protein; Provisional; Region: PRK06194
1229205012291	classical (c) SDRs; Region: SDR_c; cd05233
1229205012292	NAD(P) binding site [chemical binding]; other site
1229205012293	active site
1229205012294	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
1229205012295	Prostaglandin dehydrogenases; Region: PGDH; cd05288
1229205012296	NAD(P) binding site [chemical binding]; other site
1229205012297	substrate binding site [chemical binding]; other site
1229205012298	dimer interface [polypeptide binding]; other site
1229205012299	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1229205012300	CoenzymeA binding site [chemical binding]; other site
1229205012301	subunit interaction site [polypeptide binding]; other site
1229205012302	PHB binding site; other site
1229205012303	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1229205012304	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205012305	DNA-binding site [nucleotide binding]; DNA binding site
1229205012306	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229205012307	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205012308	homodimer interface [polypeptide binding]; other site
1229205012309	catalytic residue [active]
1229205012310	Water Stress and Hypersensitive response; Region: WHy; smart00769
1229205012311	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
1229205012312	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1229205012313	dimer interface [polypeptide binding]; other site
1229205012314	active site
1229205012315	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1229205012316	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
1229205012317	substrate binding site [chemical binding]; other site
1229205012318	oxyanion hole (OAH) forming residues; other site
1229205012319	trimer interface [polypeptide binding]; other site
1229205012320	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1229205012321	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1229205012322	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1229205012323	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
1229205012324	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
1229205012325	dimer interface [polypeptide binding]; other site
1229205012326	acyl-activating enzyme (AAE) consensus motif; other site
1229205012327	putative active site [active]
1229205012328	AMP binding site [chemical binding]; other site
1229205012329	putative CoA binding site [chemical binding]; other site
1229205012330	Uncharacterized conserved protein [Function unknown]; Region: COG0397
1229205012331	hypothetical protein; Validated; Region: PRK00029
1229205012332	methionine sulfoxide reductase B; Provisional; Region: PRK00222
1229205012333	SelR domain; Region: SelR; pfam01641
1229205012334	intracellular septation protein A; Reviewed; Region: PRK00259
1229205012335	BolA-like protein; Region: BolA; pfam01722
1229205012336	SurA N-terminal domain; Region: SurA_N_3; cl07813
1229205012337	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1229205012338	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
1229205012339	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1229205012340	dimerization interface [polypeptide binding]; other site
1229205012341	ATP binding site [chemical binding]; other site
1229205012342	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1229205012343	dimerization interface [polypeptide binding]; other site
1229205012344	ATP binding site [chemical binding]; other site
1229205012345	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1229205012346	putative active site [active]
1229205012347	catalytic triad [active]
1229205012348	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
1229205012349	putative carbohydrate kinase; Provisional; Region: PRK10565
1229205012350	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
1229205012351	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1229205012352	putative substrate binding site [chemical binding]; other site
1229205012353	putative ATP binding site [chemical binding]; other site
1229205012354	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
1229205012355	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1229205012356	active site
1229205012357	dimer interface [polypeptide binding]; other site
1229205012358	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1229205012359	dimer interface [polypeptide binding]; other site
1229205012360	active site
1229205012361	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1229205012362	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
1229205012363	Walker A/P-loop; other site
1229205012364	ATP binding site [chemical binding]; other site
1229205012365	Q-loop/lid; other site
1229205012366	ABC transporter signature motif; other site
1229205012367	Walker B; other site
1229205012368	D-loop; other site
1229205012369	H-loop/switch region; other site
1229205012370	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
1229205012371	active site
1229205012372	catalytic triad [active]
1229205012373	oxyanion hole [active]
1229205012374	switch loop; other site
1229205012375	SurA N-terminal domain; Region: SurA_N_3; cl07813
1229205012376	periplasmic folding chaperone; Provisional; Region: PRK10788
1229205012377	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
1229205012378	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1229205012379	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1229205012380	IHF dimer interface [polypeptide binding]; other site
1229205012381	IHF - DNA interface [nucleotide binding]; other site
1229205012382	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
1229205012383	Found in ATP-dependent protease La (LON); Region: LON; smart00464
1229205012384	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205012385	Walker A motif; other site
1229205012386	ATP binding site [chemical binding]; other site
1229205012387	Walker B motif; other site
1229205012388	arginine finger; other site
1229205012389	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1229205012390	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1229205012391	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1229205012392	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205012393	Walker A motif; other site
1229205012394	ATP binding site [chemical binding]; other site
1229205012395	Walker B motif; other site
1229205012396	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1229205012397	Clp protease; Region: CLP_protease; pfam00574
1229205012398	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1229205012399	oligomer interface [polypeptide binding]; other site
1229205012400	active site residues [active]
1229205012401	trigger factor; Provisional; Region: tig; PRK01490
1229205012402	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1229205012403	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1229205012404	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
1229205012405	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1229205012406	MarR family; Region: MarR_2; pfam12802
1229205012407	MarR family; Region: MarR_2; cl17246
1229205012408	Protein of unknown function (DUF3999); Region: DUF3999; pfam13163
1229205012409	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
1229205012410	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
1229205012411	active site lid residues [active]
1229205012412	substrate binding pocket [chemical binding]; other site
1229205012413	catalytic residues [active]
1229205012414	substrate-Mg2+ binding site; other site
1229205012415	aspartate-rich region 1; other site
1229205012416	aspartate-rich region 2; other site
1229205012417	osmolarity response regulator; Provisional; Region: ompR; PRK09468
1229205012418	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205012419	active site
1229205012420	phosphorylation site [posttranslational modification]
1229205012421	intermolecular recognition site; other site
1229205012422	dimerization interface [polypeptide binding]; other site
1229205012423	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229205012424	DNA binding site [nucleotide binding]
1229205012425	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1229205012426	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205012427	dimer interface [polypeptide binding]; other site
1229205012428	phosphorylation site [posttranslational modification]
1229205012429	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205012430	ATP binding site [chemical binding]; other site
1229205012431	Mg2+ binding site [ion binding]; other site
1229205012432	G-X-G motif; other site
1229205012433	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1229205012434	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1229205012435	dimer interface [polypeptide binding]; other site
1229205012436	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1229205012437	catalytic triad [active]
1229205012438	peroxidatic and resolving cysteines [active]
1229205012439	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
1229205012440	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1229205012441	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1229205012442	homotrimer interaction site [polypeptide binding]; other site
1229205012443	zinc binding site [ion binding]; other site
1229205012444	CDP-binding sites; other site
1229205012445	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1229205012446	substrate binding site; other site
1229205012447	dimer interface; other site
1229205012448	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1229205012449	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1229205012450	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1229205012451	ATP binding site [chemical binding]; other site
1229205012452	putative Mg++ binding site [ion binding]; other site
1229205012453	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1229205012454	nucleotide binding region [chemical binding]; other site
1229205012455	ATP-binding site [chemical binding]; other site
1229205012456	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1229205012457	acetylornithine deacetylase; Provisional; Region: PRK07522
1229205012458	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
1229205012459	metal binding site [ion binding]; metal-binding site
1229205012460	putative dimer interface [polypeptide binding]; other site
1229205012461	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
1229205012462	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1229205012463	tetramer interface [polypeptide binding]; other site
1229205012464	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205012465	catalytic residue [active]
1229205012466	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
1229205012467	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1229205012468	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1229205012469	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205012470	active site
1229205012471	phosphorylation site [posttranslational modification]
1229205012472	intermolecular recognition site; other site
1229205012473	dimerization interface [polypeptide binding]; other site
1229205012474	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1229205012475	PAS fold; Region: PAS_3; pfam08447
1229205012476	putative active site [active]
1229205012477	heme pocket [chemical binding]; other site
1229205012478	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229205012479	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205012480	dimer interface [polypeptide binding]; other site
1229205012481	phosphorylation site [posttranslational modification]
1229205012482	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205012483	ATP binding site [chemical binding]; other site
1229205012484	Mg2+ binding site [ion binding]; other site
1229205012485	G-X-G motif; other site
1229205012486	Response regulator receiver domain; Region: Response_reg; pfam00072
1229205012487	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205012488	active site
1229205012489	phosphorylation site [posttranslational modification]
1229205012490	intermolecular recognition site; other site
1229205012491	dimerization interface [polypeptide binding]; other site
1229205012492	Response regulator receiver domain; Region: Response_reg; pfam00072
1229205012493	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205012494	active site
1229205012495	phosphorylation site [posttranslational modification]
1229205012496	intermolecular recognition site; other site
1229205012497	dimerization interface [polypeptide binding]; other site
1229205012498	CHASE3 domain; Region: CHASE3; cl05000
1229205012499	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229205012500	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1229205012501	dimer interface [polypeptide binding]; other site
1229205012502	phosphorylation site [posttranslational modification]
1229205012503	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205012504	ATP binding site [chemical binding]; other site
1229205012505	Mg2+ binding site [ion binding]; other site
1229205012506	G-X-G motif; other site
1229205012507	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
1229205012508	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1229205012509	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
1229205012510	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229205012511	Walker A/P-loop; other site
1229205012512	ATP binding site [chemical binding]; other site
1229205012513	Q-loop/lid; other site
1229205012514	ABC transporter signature motif; other site
1229205012515	Walker B; other site
1229205012516	D-loop; other site
1229205012517	H-loop/switch region; other site
1229205012518	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
1229205012519	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
1229205012520	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
1229205012521	putative NAD(P) binding site [chemical binding]; other site
1229205012522	dimer interface [polypeptide binding]; other site
1229205012523	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205012524	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205012525	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1229205012526	putative effector binding pocket; other site
1229205012527	dimerization interface [polypeptide binding]; other site
1229205012528	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
1229205012529	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
1229205012530	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
1229205012531	active site
1229205012532	DNA binding site [nucleotide binding]
1229205012533	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
1229205012534	DNA binding site [nucleotide binding]
1229205012535	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
1229205012536	nucleotide binding site [chemical binding]; other site
1229205012537	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
1229205012538	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
1229205012539	putative DNA binding site [nucleotide binding]; other site
1229205012540	putative homodimer interface [polypeptide binding]; other site
1229205012541	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1229205012542	Cytochrome P450; Region: p450; cl12078
1229205012543	Domain of unknown function (DUF4072); Region: DUF4072; pfam13284
1229205012544	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1229205012545	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229205012546	motif II; other site
1229205012547	cystathionine beta-lyase; Provisional; Region: PRK07050
1229205012548	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1229205012549	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1229205012550	catalytic residue [active]
1229205012551	beta-ketothiolase; Provisional; Region: PRK09051
1229205012552	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1229205012553	dimer interface [polypeptide binding]; other site
1229205012554	active site
1229205012555	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1229205012556	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1229205012557	substrate binding site [chemical binding]; other site
1229205012558	ATP binding site [chemical binding]; other site
1229205012559	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
1229205012560	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1229205012561	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1229205012562	FeS/SAM binding site; other site
1229205012563	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394
1229205012564	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
1229205012565	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
1229205012566	acetyacetyl-CoA reductase; Provisional; Region: PRK12938
1229205012567	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1229205012568	NAD(P) binding site [chemical binding]; other site
1229205012569	homotetramer interface [polypeptide binding]; other site
1229205012570	homodimer interface [polypeptide binding]; other site
1229205012571	active site
1229205012572	putative acyltransferase; Provisional; Region: PRK05790
1229205012573	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1229205012574	dimer interface [polypeptide binding]; other site
1229205012575	active site
1229205012576	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
1229205012577	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
1229205012578	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
1229205012579	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
1229205012580	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1229205012581	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1229205012582	RNA binding surface [nucleotide binding]; other site
1229205012583	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1229205012584	active site
1229205012585	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
1229205012586	TRAM domain; Region: TRAM; cl01282
1229205012587	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
1229205012588	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229205012589	S-adenosylmethionine binding site [chemical binding]; other site
1229205012590	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782
1229205012591	active site
1229205012592	catalytic site [active]
1229205012593	substrate binding site [chemical binding]; other site
1229205012594	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108
1229205012595	RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394
1229205012596	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1229205012597	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1229205012598	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1229205012599	DNA binding residues [nucleotide binding]
1229205012600	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1229205012601	Peptidase family M23; Region: Peptidase_M23; pfam01551
1229205012602	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
1229205012603	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229205012604	S-adenosylmethionine binding site [chemical binding]; other site
1229205012605	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
1229205012606	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1229205012607	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
1229205012608	NAD(P) binding site [chemical binding]; other site
1229205012609	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1229205012610	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205012611	dimer interface [polypeptide binding]; other site
1229205012612	conserved gate region; other site
1229205012613	putative PBP binding loops; other site
1229205012614	ABC-ATPase subunit interface; other site
1229205012615	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1229205012616	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1229205012617	Walker A/P-loop; other site
1229205012618	ATP binding site [chemical binding]; other site
1229205012619	Q-loop/lid; other site
1229205012620	ABC transporter signature motif; other site
1229205012621	Walker B; other site
1229205012622	D-loop; other site
1229205012623	H-loop/switch region; other site
1229205012624	NMT1-like family; Region: NMT1_2; pfam13379
1229205012625	NMT1/THI5 like; Region: NMT1; pfam09084
1229205012626	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1229205012627	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1229205012628	recombination protein RecR; Reviewed; Region: recR; PRK00076
1229205012629	RecR protein; Region: RecR; pfam02132
1229205012630	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1229205012631	putative active site [active]
1229205012632	putative metal-binding site [ion binding]; other site
1229205012633	tetramer interface [polypeptide binding]; other site
1229205012634	hypothetical protein; Validated; Region: PRK00153
1229205012635	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
1229205012636	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205012637	Walker A motif; other site
1229205012638	ATP binding site [chemical binding]; other site
1229205012639	Walker B motif; other site
1229205012640	arginine finger; other site
1229205012641	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1229205012642	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1229205012643	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1229205012644	catalytic residues [active]
1229205012645	transcription termination factor Rho; Provisional; Region: rho; PRK09376
1229205012646	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
1229205012647	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
1229205012648	RNA binding site [nucleotide binding]; other site
1229205012649	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1229205012650	multimer interface [polypeptide binding]; other site
1229205012651	Walker A motif; other site
1229205012652	ATP binding site [chemical binding]; other site
1229205012653	Walker B motif; other site
1229205012654	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1229205012655	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1229205012656	DNA binding residues [nucleotide binding]
1229205012657	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205012658	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1229205012659	putative substrate translocation pore; other site
1229205012660	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167
1229205012661	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
1229205012662	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1229205012663	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
1229205012664	putative efflux protein, MATE family; Region: matE; TIGR00797
1229205012665	cation binding site [ion binding]; other site
1229205012666	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1229205012667	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1229205012668	DNA binding residues [nucleotide binding]
1229205012669	putative dimer interface [polypeptide binding]; other site
1229205012670	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
1229205012671	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
1229205012672	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1229205012673	Clp amino terminal domain; Region: Clp_N; pfam02861
1229205012674	Clp amino terminal domain; Region: Clp_N; pfam02861
1229205012675	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205012676	Walker A motif; other site
1229205012677	ATP binding site [chemical binding]; other site
1229205012678	Walker B motif; other site
1229205012679	arginine finger; other site
1229205012680	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205012681	Walker A motif; other site
1229205012682	ATP binding site [chemical binding]; other site
1229205012683	Walker B motif; other site
1229205012684	arginine finger; other site
1229205012685	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1229205012686	Transcriptional regulator; Region: Rrf2; cl17282
1229205012687	Rrf2 family protein; Region: rrf2_super; TIGR00738
1229205012688	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
1229205012689	apolar tunnel; other site
1229205012690	heme binding site [chemical binding]; other site
1229205012691	dimerization interface [polypeptide binding]; other site
1229205012692	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1229205012693	MoaE homodimer interface [polypeptide binding]; other site
1229205012694	MoaD interaction [polypeptide binding]; other site
1229205012695	active site residues [active]
1229205012696	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1229205012697	MoaE interaction surface [polypeptide binding]; other site
1229205012698	MoeB interaction surface [polypeptide binding]; other site
1229205012699	thiocarboxylated glycine; other site
1229205012700	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1229205012701	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1229205012702	dimer interface [polypeptide binding]; other site
1229205012703	putative functional site; other site
1229205012704	putative MPT binding site; other site
1229205012705	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
1229205012706	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
1229205012707	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205012708	catalytic residue [active]
1229205012709	homoserine dehydrogenase; Provisional; Region: PRK06349
1229205012710	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1229205012711	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1229205012712	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
1229205012713	aminotransferase AlaT; Validated; Region: PRK09265
1229205012714	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229205012715	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205012716	homodimer interface [polypeptide binding]; other site
1229205012717	catalytic residue [active]
1229205012718	Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560
1229205012719	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1229205012720	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
1229205012721	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051
1229205012722	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1229205012723	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1229205012724	inhibitor-cofactor binding pocket; inhibition site
1229205012725	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205012726	catalytic residue [active]
1229205012727	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1229205012728	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1229205012729	Ligand binding site; other site
1229205012730	Putative Catalytic site; other site
1229205012731	DXD motif; other site
1229205012732	putative formyltransferase; Provisional; Region: PRK06988
1229205012733	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
1229205012734	active site
1229205012735	substrate binding site [chemical binding]; other site
1229205012736	cosubstrate binding site; other site
1229205012737	catalytic site [active]
1229205012738	C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702
1229205012739	active site
1229205012740	hexamer interface [polypeptide binding]; other site
1229205012741	NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908
1229205012742	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
1229205012743	NAD binding site [chemical binding]; other site
1229205012744	substrate binding site [chemical binding]; other site
1229205012745	active site
1229205012746	4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394
1229205012747	Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939
1229205012748	putative active site [active]
1229205012749	putative catalytic site [active]
1229205012750	putative Zn binding site [ion binding]; other site
1229205012751	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1229205012752	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1229205012753	catalytic triad [active]
1229205012754	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
1229205012755	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
1229205012756	putative active site [active]
1229205012757	PhoH-like protein; Region: PhoH; pfam02562
1229205012758	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1229205012759	NlpC/P60 family; Region: NLPC_P60; pfam00877
1229205012760	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
1229205012761	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
1229205012762	putative ribose interaction site [chemical binding]; other site
1229205012763	putative ADP binding site [chemical binding]; other site
1229205012764	short chain dehydrogenase; Provisional; Region: PRK06125
1229205012765	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205012766	NAD(P) binding site [chemical binding]; other site
1229205012767	active site
1229205012768	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1229205012769	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
1229205012770	replicative DNA helicase; Provisional; Region: PRK07004
1229205012771	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1229205012772	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1229205012773	Walker A motif; other site
1229205012774	ATP binding site [chemical binding]; other site
1229205012775	Walker B motif; other site
1229205012776	DNA binding loops [nucleotide binding]
1229205012777	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1229205012778	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1229205012779	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1229205012780	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1229205012781	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
1229205012782	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1229205012783	Putative zinc-finger; Region: zf-HC2; pfam13490
1229205012784	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
1229205012785	RNA polymerase sigma factor; Provisional; Region: PRK12533
1229205012786	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1229205012787	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1229205012788	DNA binding residues [nucleotide binding]
1229205012789	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205012790	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205012791	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1229205012792	putative effector binding pocket; other site
1229205012793	dimerization interface [polypeptide binding]; other site
1229205012794	glyoxylate carboligase; Provisional; Region: PRK11269
1229205012795	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1229205012796	PYR/PP interface [polypeptide binding]; other site
1229205012797	dimer interface [polypeptide binding]; other site
1229205012798	TPP binding site [chemical binding]; other site
1229205012799	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1229205012800	Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006
1229205012801	TPP-binding site [chemical binding]; other site
1229205012802	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
1229205012803	tartronate semialdehyde reductase; Provisional; Region: PRK15059
1229205012804	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1229205012805	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
1229205012806	BON domain; Region: BON; pfam04972
1229205012807	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1229205012808	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1229205012809	active site
1229205012810	homodimer interface [polypeptide binding]; other site
1229205012811	homotetramer interface [polypeptide binding]; other site
1229205012812	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683
1229205012813	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205012814	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
1229205012815	substrate binding site [chemical binding]; other site
1229205012816	dimerization interface [polypeptide binding]; other site
1229205012817	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
1229205012818	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
1229205012819	Walker A/P-loop; other site
1229205012820	ATP binding site [chemical binding]; other site
1229205012821	Q-loop/lid; other site
1229205012822	ABC transporter signature motif; other site
1229205012823	Walker B; other site
1229205012824	D-loop; other site
1229205012825	H-loop/switch region; other site
1229205012826	TOBE-like domain; Region: TOBE_3; pfam12857
1229205012827	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205012828	dimer interface [polypeptide binding]; other site
1229205012829	conserved gate region; other site
1229205012830	putative PBP binding loops; other site
1229205012831	ABC-ATPase subunit interface; other site
1229205012832	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1229205012833	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205012834	dimer interface [polypeptide binding]; other site
1229205012835	conserved gate region; other site
1229205012836	putative PBP binding loops; other site
1229205012837	ABC-ATPase subunit interface; other site
1229205012838	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1229205012839	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229205012840	substrate binding pocket [chemical binding]; other site
1229205012841	membrane-bound complex binding site; other site
1229205012842	LexA repressor; Validated; Region: PRK00215
1229205012843	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
1229205012844	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1229205012845	Catalytic site [active]
1229205012846	Protein of unknown function (DUF2939); Region: DUF2939; pfam11159
1229205012847	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1229205012848	Ligand Binding Site [chemical binding]; other site
1229205012849	nodulation ABC transporter NodI; Provisional; Region: PRK13537
1229205012850	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
1229205012851	Walker A/P-loop; other site
1229205012852	ATP binding site [chemical binding]; other site
1229205012853	Q-loop/lid; other site
1229205012854	ABC transporter signature motif; other site
1229205012855	Walker B; other site
1229205012856	D-loop; other site
1229205012857	H-loop/switch region; other site
1229205012858	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1229205012859	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1229205012860	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1229205012861	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1229205012862	active site
1229205012863	catalytic tetrad [active]
1229205012864	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
1229205012865	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
1229205012866	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1229205012867	FMN binding site [chemical binding]; other site
1229205012868	active site
1229205012869	catalytic residues [active]
1229205012870	substrate binding site [chemical binding]; other site
1229205012871	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
1229205012872	dimer interface [polypeptide binding]; other site
1229205012873	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1229205012874	ligand binding site [chemical binding]; other site
1229205012875	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
1229205012876	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
1229205012877	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1229205012878	Walker A/P-loop; other site
1229205012879	ATP binding site [chemical binding]; other site
1229205012880	Q-loop/lid; other site
1229205012881	ABC transporter signature motif; other site
1229205012882	Walker B; other site
1229205012883	D-loop; other site
1229205012884	H-loop/switch region; other site
1229205012885	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1229205012886	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205012887	dimer interface [polypeptide binding]; other site
1229205012888	conserved gate region; other site
1229205012889	putative PBP binding loops; other site
1229205012890	ABC-ATPase subunit interface; other site
1229205012891	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
1229205012892	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1229205012893	active site
1229205012894	dimer interface [polypeptide binding]; other site
1229205012895	non-prolyl cis peptide bond; other site
1229205012896	insertion regions; other site
1229205012897	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
1229205012898	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1229205012899	substrate binding site [chemical binding]; other site
1229205012900	oxyanion hole (OAH) forming residues; other site
1229205012901	trimer interface [polypeptide binding]; other site
1229205012902	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
1229205012903	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
1229205012904	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
1229205012905	hypothetical protein; Provisional; Region: PRK02487
1229205012906	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
1229205012907	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
1229205012908	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
1229205012909	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1229205012910	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1229205012911	haemagglutination activity domain; Region: Haemagg_act; pfam05860
1229205012912	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1229205012913	Ribosomal protein S27a; Region: Ribosomal_S27; cl00876
1229205012914	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
1229205012915	nudix motif; other site
1229205012916	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
1229205012917	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
1229205012918	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
1229205012919	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
1229205012920	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
1229205012921	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
1229205012922	active site
1229205012923	catalytic residues [active]
1229205012924	FMN binding site [chemical binding]; other site
1229205012925	quinone interaction residues [chemical binding]; other site
1229205012926	substrate binding site [chemical binding]; other site
1229205012927	cystine transporter subunit; Provisional; Region: PRK11260
1229205012928	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229205012929	substrate binding pocket [chemical binding]; other site
1229205012930	membrane-bound complex binding site; other site
1229205012931	hinge residues; other site
1229205012932	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205012933	dimer interface [polypeptide binding]; other site
1229205012934	conserved gate region; other site
1229205012935	putative PBP binding loops; other site
1229205012936	ABC-ATPase subunit interface; other site
1229205012937	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1229205012938	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1229205012939	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1229205012940	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205012941	DNA-binding site [nucleotide binding]; DNA binding site
1229205012942	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1229205012943	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1229205012944	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
1229205012945	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229205012946	S-adenosylmethionine binding site [chemical binding]; other site
1229205012947	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1229205012948	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1229205012949	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1229205012950	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1229205012951	active site
1229205012952	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1229205012953	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1229205012954	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229205012955	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
1229205012956	putative ADP-binding pocket [chemical binding]; other site
1229205012957	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
1229205012958	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229205012959	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1229205012960	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229205012961	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1229205012962	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1229205012963	acyl carrier protein; Provisional; Region: PRK07081
1229205012964	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1229205012965	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1229205012966	active site
1229205012967	Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670
1229205012968	motif 1; other site
1229205012969	dimer interface [polypeptide binding]; other site
1229205012970	active site
1229205012971	motif 2; other site
1229205012972	motif 3; other site
1229205012973	Domain of unknown function (DUF1839); Region: DUF1839; pfam08893
1229205012974	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
1229205012975	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1229205012976	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
1229205012977	ligand binding site [chemical binding]; other site
1229205012978	flexible hinge region; other site
1229205012979	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1229205012980	non-specific DNA interactions [nucleotide binding]; other site
1229205012981	DNA binding site [nucleotide binding]
1229205012982	sequence specific DNA binding site [nucleotide binding]; other site
1229205012983	putative cAMP binding site [chemical binding]; other site
1229205012984	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
1229205012985	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1229205012986	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1229205012987	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
1229205012988	active site
1229205012989	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
1229205012990	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
1229205012991	tyrosine kinase; Provisional; Region: PRK11519
1229205012992	Chain length determinant protein; Region: Wzz; pfam02706
1229205012993	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
1229205012994	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1229205012995	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1229205012996	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229205012997	non-specific DNA binding site [nucleotide binding]; other site
1229205012998	salt bridge; other site
1229205012999	sequence-specific DNA binding site [nucleotide binding]; other site
1229205013000	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229205013001	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
1229205013002	putative ADP-binding pocket [chemical binding]; other site
1229205013003	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1229205013004	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229205013005	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1229205013006	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1229205013007	active site
1229205013008	dimer interface [polypeptide binding]; other site
1229205013009	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1229205013010	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
1229205013011	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1229205013012	ribonuclease R; Region: RNase_R; TIGR02063
1229205013013	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1229205013014	RNB domain; Region: RNB; pfam00773
1229205013015	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
1229205013016	RNA binding site [nucleotide binding]; other site
1229205013017	integrase; Provisional; Region: PRK09692
1229205013018	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
1229205013019	active site
1229205013020	Int/Topo IB signature motif; other site
1229205013021	TIR domain; Region: TIR_2; pfam13676
1229205013022	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1229205013023	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1229205013024	substrate binding site [chemical binding]; other site
1229205013025	ATP binding site [chemical binding]; other site
1229205013026	recombination factor protein RarA; Reviewed; Region: PRK13342
1229205013027	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
1229205013028	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317
1229205013029	Domain of unknown function (DUF4400); Region: DUF4400; pfam14348
1229205013030	conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743
1229205013031	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
1229205013032	Putative helicase; Region: TraI_2; pfam07514
1229205013033	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1229205013034	Zn2+ binding site [ion binding]; other site
1229205013035	Mg2+ binding site [ion binding]; other site
1229205013036	Protein of unknown function (DUF1528); Region: DUF1528; pfam07515
1229205013037	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1229205013038	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1229205013039	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1229205013040	catalytic residue [active]
1229205013041	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
1229205013042	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1229205013043	Walker A motif; other site
1229205013044	hexamer interface [polypeptide binding]; other site
1229205013045	ATP binding site [chemical binding]; other site
1229205013046	Walker B motif; other site
1229205013047	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
1229205013048	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
1229205013049	conjugal transfer protein TrbJ; Provisional; Region: PRK13874; cl02193
1229205013050	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
1229205013051	VirB8 protein; Region: VirB8; pfam04335
1229205013052	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
1229205013053	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
1229205013054	VirB7 interaction site; other site
1229205013055	conjugal transfer protein TrbI; Provisional; Region: PRK13881
1229205013056	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
1229205013057	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
1229205013058	VirB7 interaction site; other site
1229205013059	Family description; Region: UvrD_C_2; pfam13538
1229205013060	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861
1229205013061	Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952
1229205013062	Predicted nucleotidyltransferase [General function prediction    only]; Region: COG4849
1229205013063	ACT domain; Region: ACT_3; pfam10000
1229205013064	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602
1229205013065	Family description; Region: ACT_7; pfam13840
1229205013066	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1229205013067	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229205013068	non-specific DNA binding site [nucleotide binding]; other site
1229205013069	salt bridge; other site
1229205013070	sequence-specific DNA binding site [nucleotide binding]; other site
1229205013071	Protein of unknown function (DUF3577); Region: DUF3577; pfam12101
1229205013072	Antirestriction protein; Region: Antirestrict; pfam03230
1229205013073	Protein of unknown function (DUF3275); Region: DUF3275; pfam11679
1229205013074	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1229205013075	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1229205013076	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
1229205013077	ATP binding site [chemical binding]; other site
1229205013078	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
1229205013079	nucleotide binding region [chemical binding]; other site
1229205013080	ATP-binding site [chemical binding]; other site
1229205013081	Protein of unknown function (DUF3085); Region: DUF3085; pfam11284
1229205013082	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
1229205013083	active site
1229205013084	catalytic triad [active]
1229205013085	dimer interface [polypeptide binding]; other site
1229205013086	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1229205013087	IHF dimer interface [polypeptide binding]; other site
1229205013088	IHF - DNA interface [nucleotide binding]; other site
1229205013089	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1229205013090	PLD-like domain; Region: PLDc_2; pfam13091
1229205013091	putative active site [active]
1229205013092	catalytic site [active]
1229205013093	Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173
1229205013094	putative active site [active]
1229205013095	catalytic site [active]
1229205013096	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
1229205013097	generic binding surface I; other site
1229205013098	generic binding surface II; other site
1229205013099	Domain of unknown function (DUF1845); Region: DUF1845; cl07481
1229205013100	integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764
1229205013101	ParB-like nuclease domain; Region: ParB; smart00470
1229205013102	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1229205013103	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1229205013104	P-loop; other site
1229205013105	Magnesium ion binding site [ion binding]; other site
1229205013106	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1229205013107	Magnesium ion binding site [ion binding]; other site
1229205013108	Helix-turn-helix domain; Region: HTH_17; pfam12728
1229205013109	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1229205013110	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229205013111	non-specific DNA binding site [nucleotide binding]; other site
1229205013112	salt bridge; other site
1229205013113	sequence-specific DNA binding site [nucleotide binding]; other site
1229205013114	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
1229205013115	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1229205013116	putative di-iron ligands [ion binding]; other site
1229205013117	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
1229205013118	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1229205013119	chromosome replication initiation inhibitor protein; Provisional; Region: PRK13348
1229205013120	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205013121	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205013122	dimerization interface [polypeptide binding]; other site
1229205013123	putative transposase OrfB; Reviewed; Region: PHA02517
1229205013124	HTH-like domain; Region: HTH_21; pfam13276
1229205013125	Integrase core domain; Region: rve; pfam00665
1229205013126	Integrase core domain; Region: rve_3; pfam13683
1229205013127	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1229205013128	Transposase; Region: HTH_Tnp_1; cl17663
1229205013129	Transposase domain (DUF772); Region: DUF772; pfam05598
1229205013130	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1229205013131	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
1229205013132	Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461
1229205013133	dimer interface [polypeptide binding]; other site
1229205013134	active site
1229205013135	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1229205013136	Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177
1229205013137	active site
1229205013138	dimer interface [polypeptide binding]; other site
1229205013139	metal binding site [ion binding]; metal-binding site
1229205013140	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1229205013141	NAD(P) binding site [chemical binding]; other site
1229205013142	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1229205013143	catalytic residues [active]
1229205013144	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205013145	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205013146	trimer interface [polypeptide binding]; other site
1229205013147	eyelet of channel; other site
1229205013148	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
1229205013149	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
1229205013150	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
1229205013151	maleylacetoacetate isomerase; Region: maiA; TIGR01262
1229205013152	C-terminal domain interface [polypeptide binding]; other site
1229205013153	GSH binding site (G-site) [chemical binding]; other site
1229205013154	putative dimer interface [polypeptide binding]; other site
1229205013155	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
1229205013156	dimer interface [polypeptide binding]; other site
1229205013157	N-terminal domain interface [polypeptide binding]; other site
1229205013158	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
1229205013159	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1229205013160	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
1229205013161	Protein of unknown function (DUF2783); Region: DUF2783; pfam10932
1229205013162	FAD-dependent oxidoreductase; Provisional; Region: PRK08132
1229205013163	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1229205013164	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205013165	putative substrate translocation pore; other site
1229205013166	fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266
1229205013167	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
1229205013168	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1229205013169	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1229205013170	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1229205013171	Zn binding site [ion binding]; other site
1229205013172	acetyl-CoA acetyltransferase; Provisional; Region: PRK07516
1229205013173	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1229205013174	active site
1229205013175	Homeodomain-like domain; Region: HTH_23; pfam13384
1229205013176	Winged helix-turn helix; Region: HTH_29; pfam13551
1229205013177	Homeodomain-like domain; Region: HTH_32; pfam13565
1229205013178	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1229205013179	PAS domain; Region: PAS_9; pfam13426
1229205013180	putative active site [active]
1229205013181	heme pocket [chemical binding]; other site
1229205013182	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1229205013183	DNA binding residues [nucleotide binding]
1229205013184	dimerization interface [polypeptide binding]; other site
1229205013185	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1229205013186	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1229205013187	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1229205013188	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1229205013189	FMN-binding pocket [chemical binding]; other site
1229205013190	flavin binding motif; other site
1229205013191	phosphate binding motif [ion binding]; other site
1229205013192	beta-alpha-beta structure motif; other site
1229205013193	NAD binding pocket [chemical binding]; other site
1229205013194	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1229205013195	catalytic loop [active]
1229205013196	iron binding site [ion binding]; other site
1229205013197	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1229205013198	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1229205013199	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1229205013200	iron-sulfur cluster [ion binding]; other site
1229205013201	[2Fe-2S] cluster binding site [ion binding]; other site
1229205013202	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1229205013203	hydrophobic ligand binding site; other site
1229205013204	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1229205013205	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
1229205013206	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1229205013207	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1229205013208	Transposase; Region: HTH_Tnp_1; cl17663
1229205013209	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1229205013210	Transposase; Region: HTH_Tnp_1; pfam01527
1229205013211	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1229205013212	Integrase core domain; Region: rve; pfam00665
1229205013213	Integrase core domain; Region: rve_3; pfam13683
1229205013214	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1229205013215	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1229205013216	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1229205013217	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205013218	NAD(P) binding site [chemical binding]; other site
1229205013219	active site
1229205013220	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229205013221	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205013222	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
1229205013223	iron-sulfur cluster [ion binding]; other site
1229205013224	[2Fe-2S] cluster binding site [ion binding]; other site
1229205013225	C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360
1229205013226	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1229205013227	putative active site [active]
1229205013228	putative metal binding site [ion binding]; other site
1229205013229	hypothetical protein; Provisional; Region: PRK06847
1229205013230	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1229205013231	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1229205013232	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1229205013233	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205013234	putative substrate translocation pore; other site
1229205013235	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205013236	eyelet of channel; other site
1229205013237	trimer interface [polypeptide binding]; other site
1229205013238	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205013239	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1229205013240	CoenzymeA binding site [chemical binding]; other site
1229205013241	subunit interaction site [polypeptide binding]; other site
1229205013242	PHB binding site; other site
1229205013243	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1229205013244	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1229205013245	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1229205013246	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1229205013247	Cupin domain; Region: Cupin_2; pfam07883
1229205013248	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
1229205013249	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229205013250	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229205013251	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1229205013252	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205013253	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1229205013254	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1229205013255	iron-sulfur cluster [ion binding]; other site
1229205013256	[2Fe-2S] cluster binding site [ion binding]; other site
1229205013257	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1229205013258	hydrophobic ligand binding site; other site
1229205013259	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229205013260	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229205013261	succinic semialdehyde dehydrogenase; Region: PLN02278
1229205013262	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1229205013263	tetramerization interface [polypeptide binding]; other site
1229205013264	NAD(P) binding site [chemical binding]; other site
1229205013265	catalytic residues [active]
1229205013266	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1229205013267	inhibitor site; inhibition site
1229205013268	active site
1229205013269	dimer interface [polypeptide binding]; other site
1229205013270	catalytic residue [active]
1229205013271	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
1229205013272	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
1229205013273	Uncharacterized conserved protein [Function unknown]; Region: COG2353
1229205013274	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1229205013275	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205013276	DNA-binding site [nucleotide binding]; DNA binding site
1229205013277	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1229205013278	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1229205013279	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1229205013280	iron-sulfur cluster [ion binding]; other site
1229205013281	[2Fe-2S] cluster binding site [ion binding]; other site
1229205013282	C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
1229205013283	alpha subunit interface [polypeptide binding]; other site
1229205013284	active site
1229205013285	substrate binding site [chemical binding]; other site
1229205013286	Fe binding site [ion binding]; other site
1229205013287	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
1229205013288	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205013289	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205013290	dimerization interface [polypeptide binding]; other site
1229205013291	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205013292	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205013293	trimer interface [polypeptide binding]; other site
1229205013294	eyelet of channel; other site
1229205013295	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1229205013296	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1229205013297	FMN-binding pocket [chemical binding]; other site
1229205013298	flavin binding motif; other site
1229205013299	phosphate binding motif [ion binding]; other site
1229205013300	beta-alpha-beta structure motif; other site
1229205013301	NAD binding pocket [chemical binding]; other site
1229205013302	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1229205013303	catalytic loop [active]
1229205013304	iron binding site [ion binding]; other site
1229205013305	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
1229205013306	Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752
1229205013307	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1229205013308	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1229205013309	iron-sulfur cluster [ion binding]; other site
1229205013310	[2Fe-2S] cluster binding site [ion binding]; other site
1229205013311	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1229205013312	hydrophobic ligand binding site; other site
1229205013313	hypothetical protein; Validated; Region: PRK08245
1229205013314	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1229205013315	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1229205013316	putative DNA binding site [nucleotide binding]; other site
1229205013317	putative Zn2+ binding site [ion binding]; other site
1229205013318	Bacterial transcriptional regulator; Region: IclR; pfam01614
1229205013319	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1229205013320	aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021
1229205013321	active site
1229205013322	catalytic residues [active]
1229205013323	SnoaL-like domain; Region: SnoaL_2; pfam12680
1229205013324	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1229205013325	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
1229205013326	dimer interface [polypeptide binding]; other site
1229205013327	NADP binding site [chemical binding]; other site
1229205013328	catalytic residues [active]
1229205013329	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
1229205013330	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1229205013331	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205013332	NAD(P) binding site [chemical binding]; other site
1229205013333	active site
1229205013334	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1229205013335	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
1229205013336	active site pocket [active]
1229205013337	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1229205013338	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205013339	D-galactonate transporter; Region: 2A0114; TIGR00893
1229205013340	putative substrate translocation pore; other site
1229205013341	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205013342	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205013343	trimer interface [polypeptide binding]; other site
1229205013344	eyelet of channel; other site
1229205013345	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205013346	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205013347	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205013348	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1229205013349	putative effector binding pocket; other site
1229205013350	dimerization interface [polypeptide binding]; other site
1229205013351	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
1229205013352	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
1229205013353	putative active site [active]
1229205013354	metal binding site [ion binding]; metal-binding site
1229205013355	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1229205013356	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1229205013357	putative NAD(P) binding site [chemical binding]; other site
1229205013358	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229205013359	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
1229205013360	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205013361	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205013362	trimer interface [polypeptide binding]; other site
1229205013363	eyelet of channel; other site
1229205013364	amino acid permease (GABA permease); Region: 2A0304; TIGR00907
1229205013365	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
1229205013366	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1229205013367	active site
1229205013368	enolase; Provisional; Region: eno; PRK00077
1229205013369	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1229205013370	dimer interface [polypeptide binding]; other site
1229205013371	metal binding site [ion binding]; metal-binding site
1229205013372	substrate binding pocket [chemical binding]; other site
1229205013373	ethanolamine permease; Region: 2A0305; TIGR00908
1229205013374	Proteobacterial glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK_like_proteobact; cd07794
1229205013375	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
1229205013376	N- and C-terminal domain interface [polypeptide binding]; other site
1229205013377	active site
1229205013378	MgATP binding site [chemical binding]; other site
1229205013379	catalytic site [active]
1229205013380	metal binding site [ion binding]; metal-binding site
1229205013381	putative homotetramer interface [polypeptide binding]; other site
1229205013382	putative homodimer interface [polypeptide binding]; other site
1229205013383	putative glycerol binding site [chemical binding]; other site
1229205013384	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1229205013385	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1229205013386	Predicted dehydrogenase [General function prediction only]; Region: COG0579
1229205013387	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1229205013388	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1229205013389	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1229205013390	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1229205013391	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1229205013392	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
1229205013393	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1229205013394	tetrameric interface [polypeptide binding]; other site
1229205013395	activator binding site; other site
1229205013396	NADP binding site [chemical binding]; other site
1229205013397	substrate binding site [chemical binding]; other site
1229205013398	catalytic residues [active]
1229205013399	pyruvate kinase; Provisional; Region: PRK06247
1229205013400	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1229205013401	domain interfaces; other site
1229205013402	active site
1229205013403	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1229205013404	phosphate binding site [ion binding]; other site
1229205013405	cyclase homology domain; Region: CHD; cd07302
1229205013406	nucleotidyl binding site; other site
1229205013407	dimer interface [polypeptide binding]; other site
1229205013408	metal binding site [ion binding]; metal-binding site
1229205013409	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1229205013410	RNA ligase; Region: RNA_lig_T4_1; cl09743
1229205013411	Protein of unknown function (DUF993); Region: DUF993; pfam06187
1229205013412	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745
1229205013413	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205013414	NAD(P) binding site [chemical binding]; other site
1229205013415	active site
1229205013416	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229205013417	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229205013418	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
1229205013419	Coenzyme A transferase; Region: CoA_trans; smart00882
1229205013420	Coenzyme A transferase; Region: CoA_trans; cl17247
1229205013421	enoyl-CoA hydratase; Provisional; Region: PRK06688
1229205013422	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1229205013423	substrate binding site [chemical binding]; other site
1229205013424	oxyanion hole (OAH) forming residues; other site
1229205013425	trimer interface [polypeptide binding]; other site
1229205013426	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
1229205013427	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1229205013428	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1229205013429	shikimate binding site; other site
1229205013430	NAD(P) binding site [chemical binding]; other site
1229205013431	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205013432	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229205013433	putative substrate translocation pore; other site
1229205013434	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
1229205013435	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
1229205013436	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
1229205013437	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
1229205013438	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1229205013439	Integrase core domain; Region: rve; pfam00665
1229205013440	Integrase core domain; Region: rve_3; pfam13683
1229205013441	glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495
1229205013442	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229205013443	substrate binding pocket [chemical binding]; other site
1229205013444	membrane-bound complex binding site; other site
1229205013445	hinge residues; other site
1229205013446	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1229205013447	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205013448	dimer interface [polypeptide binding]; other site
1229205013449	conserved gate region; other site
1229205013450	putative PBP binding loops; other site
1229205013451	ABC-ATPase subunit interface; other site
1229205013452	glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493
1229205013453	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1229205013454	Walker A/P-loop; other site
1229205013455	ATP binding site [chemical binding]; other site
1229205013456	Q-loop/lid; other site
1229205013457	ABC transporter signature motif; other site
1229205013458	Walker B; other site
1229205013459	D-loop; other site
1229205013460	H-loop/switch region; other site
1229205013461	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
1229205013462	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1229205013463	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1229205013464	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1229205013465	putative active site [active]
1229205013466	RibD C-terminal domain; Region: RibD_C; cl17279
1229205013467	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1229205013468	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1229205013469	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205013470	DNA-binding site [nucleotide binding]; DNA binding site
1229205013471	FCD domain; Region: FCD; pfam07729
1229205013472	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1229205013473	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1229205013474	Walker A/P-loop; other site
1229205013475	ATP binding site [chemical binding]; other site
1229205013476	Q-loop/lid; other site
1229205013477	ABC transporter signature motif; other site
1229205013478	Walker B; other site
1229205013479	D-loop; other site
1229205013480	H-loop/switch region; other site
1229205013481	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1229205013482	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1229205013483	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1229205013484	TM-ABC transporter signature motif; other site
1229205013485	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310
1229205013486	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1229205013487	putative ligand binding site [chemical binding]; other site
1229205013488	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1229205013489	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
1229205013490	putative NAD(P) binding site [chemical binding]; other site
1229205013491	catalytic Zn binding site [ion binding]; other site
1229205013492	structural Zn binding site [ion binding]; other site
1229205013493	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
1229205013494	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1229205013495	Domain of unknown function (DUF3355); Region: DUF3355; pfam11835
1229205013496	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1229205013497	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205013498	D-galactonate transporter; Region: 2A0114; TIGR00893
1229205013499	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205013500	ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994
1229205013501	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252
1229205013502	putative active site [active]
1229205013503	Zn binding site [ion binding]; other site
1229205013504	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
1229205013505	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205013506	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1229205013507	dimerization interface [polypeptide binding]; other site
1229205013508	substrate binding pocket [chemical binding]; other site
1229205013509	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1229205013510	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1229205013511	catalytic site [active]
1229205013512	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1229205013513	PAS domain; Region: PAS_9; pfam13426
1229205013514	putative active site [active]
1229205013515	heme pocket [chemical binding]; other site
1229205013516	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229205013517	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205013518	dimer interface [polypeptide binding]; other site
1229205013519	phosphorylation site [posttranslational modification]
1229205013520	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205013521	ATP binding site [chemical binding]; other site
1229205013522	Mg2+ binding site [ion binding]; other site
1229205013523	G-X-G motif; other site
1229205013524	Response regulator receiver domain; Region: Response_reg; pfam00072
1229205013525	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205013526	active site
1229205013527	phosphorylation site [posttranslational modification]
1229205013528	intermolecular recognition site; other site
1229205013529	dimerization interface [polypeptide binding]; other site
1229205013530	Malonate transporter MadL subunit; Region: MadL; cl04273
1229205013531	malonate transporter, MadM subunit; Region: malonate_madM; TIGR00808
1229205013532	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205013533	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205013534	The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416
1229205013535	putative dimerization interface [polypeptide binding]; other site
1229205013536	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
1229205013537	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
1229205013538	[4Fe-4S] binding site [ion binding]; other site
1229205013539	molybdopterin cofactor binding site; other site
1229205013540	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
1229205013541	molybdopterin cofactor binding site; other site
1229205013542	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1229205013543	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1229205013544	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1229205013545	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1229205013546	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
1229205013547	nitrite reductase subunit NirD; Provisional; Region: PRK14989
1229205013548	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1229205013549	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1229205013550	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1229205013551	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1229205013552	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
1229205013553	Protein of unknown function (DUF3579); Region: DUF3579; pfam12112
1229205013554	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1229205013555	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205013556	active site
1229205013557	phosphorylation site [posttranslational modification]
1229205013558	intermolecular recognition site; other site
1229205013559	dimerization interface [polypeptide binding]; other site
1229205013560	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205013561	Walker A motif; other site
1229205013562	ATP binding site [chemical binding]; other site
1229205013563	Walker B motif; other site
1229205013564	arginine finger; other site
1229205013565	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1229205013566	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
1229205013567	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205013568	dimer interface [polypeptide binding]; other site
1229205013569	phosphorylation site [posttranslational modification]
1229205013570	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205013571	ATP binding site [chemical binding]; other site
1229205013572	Mg2+ binding site [ion binding]; other site
1229205013573	G-X-G motif; other site
1229205013574	2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390
1229205013575	short chain dehydrogenase; Provisional; Region: PRK06180
1229205013576	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1229205013577	NADP binding site [chemical binding]; other site
1229205013578	active site
1229205013579	steroid binding site; other site
1229205013580	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
1229205013581	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1229205013582	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1229205013583	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229205013584	substrate binding pocket [chemical binding]; other site
1229205013585	membrane-bound complex binding site; other site
1229205013586	hinge residues; other site
1229205013587	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1229205013588	dimer interface [polypeptide binding]; other site
1229205013589	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1229205013590	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
1229205013591	Na binding site [ion binding]; other site
1229205013592	Protein of unknown function, DUF485; Region: DUF485; pfam04341
1229205013593	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
1229205013594	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229205013595	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229205013596	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1229205013597	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1229205013598	Bacterial transcriptional regulator; Region: IclR; pfam01614
1229205013599	crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155
1229205013600	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934
1229205013601	acyl-activating enzyme (AAE) consensus motif; other site
1229205013602	putative AMP binding site [chemical binding]; other site
1229205013603	putative active site [active]
1229205013604	putative CoA binding site [chemical binding]; other site
1229205013605	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1229205013606	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205013607	dimer interface [polypeptide binding]; other site
1229205013608	conserved gate region; other site
1229205013609	putative PBP binding loops; other site
1229205013610	ABC-ATPase subunit interface; other site
1229205013611	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1229205013612	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205013613	dimer interface [polypeptide binding]; other site
1229205013614	conserved gate region; other site
1229205013615	putative PBP binding loops; other site
1229205013616	ABC-ATPase subunit interface; other site
1229205013617	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1229205013618	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229205013619	Walker A/P-loop; other site
1229205013620	ATP binding site [chemical binding]; other site
1229205013621	Q-loop/lid; other site
1229205013622	ABC transporter signature motif; other site
1229205013623	Walker B; other site
1229205013624	D-loop; other site
1229205013625	H-loop/switch region; other site
1229205013626	TOBE domain; Region: TOBE_2; pfam08402
1229205013627	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1229205013628	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1229205013629	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1229205013630	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1229205013631	substrate binding site [chemical binding]; other site
1229205013632	oxyanion hole (OAH) forming residues; other site
1229205013633	trimer interface [polypeptide binding]; other site
1229205013634	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1229205013635	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
1229205013636	putative metal binding site; other site
1229205013637	benzoate transport; Region: 2A0115; TIGR00895
1229205013638	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205013639	putative substrate translocation pore; other site
1229205013640	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205013641	Protein of unknown function (DUF3303); Region: DUF3303; pfam11746
1229205013642	HipA N-terminal domain; Region: Couple_hipA; cl11853
1229205013643	HipA-like N-terminal domain; Region: HipA_N; pfam07805
1229205013644	HipA-like C-terminal domain; Region: HipA_C; pfam07804
1229205013645	TIGR02677 family protein; Region: TIGR02677
1229205013646	Protein of unknown function (DUF2397); Region: DUF2397; pfam09660
1229205013647	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
1229205013648	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205013649	Walker A motif; other site
1229205013650	ATP binding site [chemical binding]; other site
1229205013651	Walker B motif; other site
1229205013652	arginine finger; other site
1229205013653	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
1229205013654	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1229205013655	Integrase core domain; Region: rve; pfam00665
1229205013656	integrase; Provisional; Region: PRK09692
1229205013657	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
1229205013658	active site
1229205013659	Int/Topo IB signature motif; other site
1229205013660	Protein of unknown function DUF45; Region: DUF45; pfam01863
1229205013661	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
1229205013662	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1229205013663	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1229205013664	ATP binding site [chemical binding]; other site
1229205013665	putative Mg++ binding site [ion binding]; other site
1229205013666	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1229205013667	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1229205013668	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1229205013669	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1229205013670	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
1229205013671	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1229205013672	Domain of unknown function (DUF932); Region: DUF932; pfam06067
1229205013673	ParB-like nuclease domain; Region: ParBc; pfam02195
1229205013674	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1229205013675	ATP binding site [chemical binding]; other site
1229205013676	putative Mg++ binding site [ion binding]; other site
1229205013677	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1229205013678	nucleotide binding region [chemical binding]; other site
1229205013679	ATP-binding site [chemical binding]; other site
1229205013680	ACT domain; Region: ACT_3; pfam10000
1229205013681	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602
1229205013682	Family description; Region: ACT_7; pfam13840
1229205013683	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1229205013684	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229205013685	sequence-specific DNA binding site [nucleotide binding]; other site
1229205013686	salt bridge; other site
1229205013687	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1229205013688	IHF dimer interface [polypeptide binding]; other site
1229205013689	IHF - DNA interface [nucleotide binding]; other site
1229205013690	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1229205013691	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229205013692	non-specific DNA binding site [nucleotide binding]; other site
1229205013693	salt bridge; other site
1229205013694	sequence-specific DNA binding site [nucleotide binding]; other site
1229205013695	type IV secretion system T-DNA border endonuclease VirD2; Provisional; Region: PRK13863
1229205013696	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304
1229205013697	Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707
1229205013698	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
1229205013699	active site
1229205013700	metal binding site [ion binding]; metal-binding site
1229205013701	interdomain interaction site; other site
1229205013702	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
1229205013703	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1229205013704	Walker A motif; other site
1229205013705	ATP binding site [chemical binding]; other site
1229205013706	Walker B motif; other site
1229205013707	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
1229205013708	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1229205013709	Walker A motif; other site
1229205013710	hexamer interface [polypeptide binding]; other site
1229205013711	ATP binding site [chemical binding]; other site
1229205013712	Walker B motif; other site
1229205013713	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
1229205013714	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
1229205013715	VirB7 interaction site; other site
1229205013716	VirB8 protein; Region: VirB8; pfam04335
1229205013717	P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791
1229205013718	Type IV secretion system proteins; Region: T4SS; pfam07996
1229205013719	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
1229205013720	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
1229205013721	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
1229205013722	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
1229205013723	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1229205013724	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1229205013725	catalytic residue [active]
1229205013726	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205013727	dimerization interface [polypeptide binding]; other site
1229205013728	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
1229205013729	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1229205013730	putative di-iron ligands [ion binding]; other site
1229205013731	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
1229205013732	chromosome replication initiation inhibitor protein; Provisional; Region: PRK13348
1229205013733	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205013734	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205013735	dimerization interface [polypeptide binding]; other site
1229205013736	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
1229205013737	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
1229205013738	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
1229205013739	NADP binding site [chemical binding]; other site
1229205013740	dimer interface [polypeptide binding]; other site
1229205013741	adenosine deaminase; Provisional; Region: PRK09358
1229205013742	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
1229205013743	active site
1229205013744	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
1229205013745	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1229205013746	phosphate binding site [ion binding]; other site
1229205013747	NMT1/THI5 like; Region: NMT1; pfam09084
1229205013748	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
1229205013749	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205013750	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205013751	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1229205013752	dimerization interface [polypeptide binding]; other site
1229205013753	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1229205013754	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1229205013755	CoA binding domain; Region: CoA_binding_2; pfam13380
1229205013756	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
1229205013757	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
1229205013758	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
1229205013759	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1229205013760	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1229205013761	substrate binding site [chemical binding]; other site
1229205013762	oxyanion hole (OAH) forming residues; other site
1229205013763	trimer interface [polypeptide binding]; other site
1229205013764	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1229205013765	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1229205013766	Walker A/P-loop; other site
1229205013767	ATP binding site [chemical binding]; other site
1229205013768	Q-loop/lid; other site
1229205013769	ABC transporter signature motif; other site
1229205013770	Walker B; other site
1229205013771	D-loop; other site
1229205013772	H-loop/switch region; other site
1229205013773	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1229205013774	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205013775	dimer interface [polypeptide binding]; other site
1229205013776	conserved gate region; other site
1229205013777	ABC-ATPase subunit interface; other site
1229205013778	Predicted thioesterase [General function prediction only]; Region: COG5496
1229205013779	aldolase II superfamily protein; Provisional; Region: PRK07044
1229205013780	intersubunit interface [polypeptide binding]; other site
1229205013781	active site
1229205013782	Zn2+ binding site [ion binding]; other site
1229205013783	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
1229205013784	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1229205013785	putative ligand binding site [chemical binding]; other site
1229205013786	NAD binding site [chemical binding]; other site
1229205013787	dimerization interface [polypeptide binding]; other site
1229205013788	catalytic site [active]
1229205013789	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
1229205013790	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
1229205013791	active site
1229205013792	purine riboside binding site [chemical binding]; other site
1229205013793	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205013794	trimer interface [polypeptide binding]; other site
1229205013795	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205013796	eyelet of channel; other site
1229205013797	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205013798	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205013799	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205013800	dimerization interface [polypeptide binding]; other site
1229205013801	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1229205013802	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1229205013803	active site
1229205013804	non-prolyl cis peptide bond; other site
1229205013805	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1229205013806	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1229205013807	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
1229205013808	Na binding site [ion binding]; other site
1229205013809	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1229205013810	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1229205013811	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1229205013812	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1229205013813	DDE superfamily endonuclease; Region: DDE_5; pfam13546
1229205013814	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1229205013815	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1229205013816	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1229205013817	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1229205013818	dimer interface [polypeptide binding]; other site
1229205013819	putative CheW interface [polypeptide binding]; other site
1229205013820	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205013821	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205013822	trimer interface [polypeptide binding]; other site
1229205013823	eyelet of channel; other site
1229205013824	choline dehydrogenase; Validated; Region: PRK02106
1229205013825	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1229205013826	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1229205013827	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
1229205013828	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1229205013829	NAD binding site [chemical binding]; other site
1229205013830	catalytic residues [active]
1229205013831	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
1229205013832	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1229205013833	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1229205013834	FMN-binding pocket [chemical binding]; other site
1229205013835	flavin binding motif; other site
1229205013836	phosphate binding motif [ion binding]; other site
1229205013837	beta-alpha-beta structure motif; other site
1229205013838	NAD binding pocket [chemical binding]; other site
1229205013839	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1229205013840	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1229205013841	catalytic loop [active]
1229205013842	iron binding site [ion binding]; other site
1229205013843	Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479
1229205013844	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1229205013845	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1229205013846	hydrophobic ligand binding site; other site
1229205013847	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205013848	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205013849	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
1229205013850	putative dimerization interface [polypeptide binding]; other site
1229205013851	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1229205013852	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1229205013853	Subunit B of the Class III extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, which catalyzes the oxidization and subsequent ring-opening of protocatechuate; Region: PCA_45_Dioxygenase_B; cd07364
1229205013854	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
1229205013855	active site
1229205013856	dimer interface [polypeptide binding]; other site
1229205013857	Fe(II) binding site [ion binding]; other site
1229205013858	tetramer interface [polypeptide binding]; other site
1229205013859	The A subunit of Protocatechuate 4,5-dioxygenase (LigAB) is the smaller, non-catalytic subunit; Region: PCA_45_Doxase_A; cd07924
1229205013860	tetramer interface [polypeptide binding]; other site
1229205013861	dimer interface [polypeptide binding]; other site
1229205013862	active site
1229205013863	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
1229205013864	2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311
1229205013865	active site
1229205013866	hypothetical protein; Provisional; Region: PRK09262
1229205013867	Amidohydrolase; Region: Amidohydro_2; pfam04909
1229205013868	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205013869	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205013870	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
1229205013871	putative dimerization interface [polypeptide binding]; other site
1229205013872	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205013873	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205013874	trimer interface [polypeptide binding]; other site
1229205013875	eyelet of channel; other site
1229205013876	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229205013877	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1229205013878	catalytic triad [active]
1229205013879	conserved cis-peptide bond; other site
1229205013880	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1229205013881	Transposase; Region: HTH_Tnp_1; pfam01527
1229205013882	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1229205013883	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1229205013884	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
1229205013885	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1229205013886	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
1229205013887	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1229205013888	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
1229205013889	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1229205013890	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
1229205013891	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1229205013892	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1229205013893	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1229205013894	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1229205013895	Transposase; Region: HTH_Tnp_1; pfam01527
1229205013896	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
1229205013897	drug efflux system protein MdtG; Provisional; Region: PRK09874
1229205013898	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205013899	putative substrate translocation pore; other site
1229205013900	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1229205013901	DNA-binding site [nucleotide binding]; DNA binding site
1229205013902	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
1229205013903	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1229205013904	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
1229205013905	catalytic triad [active]
1229205013906	dimer interface [polypeptide binding]; other site
1229205013907	NHL repeat; Region: NHL; pfam01436
1229205013908	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1229205013909	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1229205013910	Zn binding site [ion binding]; other site
1229205013911	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1229205013912	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1229205013913	FMN-binding pocket [chemical binding]; other site
1229205013914	flavin binding motif; other site
1229205013915	phosphate binding motif [ion binding]; other site
1229205013916	beta-alpha-beta structure motif; other site
1229205013917	NAD binding pocket [chemical binding]; other site
1229205013918	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1229205013919	catalytic loop [active]
1229205013920	iron binding site [ion binding]; other site
1229205013921	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
1229205013922	iron-sulfur cluster [ion binding]; other site
1229205013923	[2Fe-2S] cluster binding site [ion binding]; other site
1229205013924	Amidohydrolase; Region: Amidohydro_2; pfam04909
1229205013925	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1229205013926	succinic semialdehyde dehydrogenase; Region: PLN02278
1229205013927	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1229205013928	tetramerization interface [polypeptide binding]; other site
1229205013929	NAD(P) binding site [chemical binding]; other site
1229205013930	catalytic residues [active]
1229205013931	manganese transport protein MntH; Reviewed; Region: PRK00701
1229205013932	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1229205013933	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1229205013934	dimer interface [polypeptide binding]; other site
1229205013935	putative CheW interface [polypeptide binding]; other site
1229205013936	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
1229205013937	putative active site [active]
1229205013938	putative metal binding site [ion binding]; other site
1229205013939	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
1229205013940	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1229205013941	integrase; Provisional; Region: PRK09692
1229205013942	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
1229205013943	active site
1229205013944	Int/Topo IB signature motif; other site
1229205013945	GMP synthase; Reviewed; Region: guaA; PRK00074
1229205013946	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1229205013947	AMP/PPi binding site [chemical binding]; other site
1229205013948	candidate oxyanion hole; other site
1229205013949	catalytic triad [active]
1229205013950	potential glutamine specificity residues [chemical binding]; other site
1229205013951	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1229205013952	ATP Binding subdomain [chemical binding]; other site
1229205013953	Ligand Binding sites [chemical binding]; other site
1229205013954	Dimerization subdomain; other site
1229205013955	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1229205013956	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1229205013957	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1229205013958	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1229205013959	active site
1229205013960	EamA-like transporter family; Region: EamA; pfam00892
1229205013961	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1229205013962	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2914
1229205013963	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
1229205013964	putative coenzyme Q binding site [chemical binding]; other site
1229205013965	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1229205013966	SmpB-tmRNA interface; other site
1229205013967	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1229205013968	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
1229205013969	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
1229205013970	phosphoenolpyruvate synthase; Validated; Region: PRK06464
1229205013971	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1229205013972	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1229205013973	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1229205013974	PEP synthetase regulatory protein; Provisional; Region: PRK05339
1229205013975	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1229205013976	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1229205013977	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1229205013978	RNA/DNA hybrid binding site [nucleotide binding]; other site
1229205013979	active site
1229205013980	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
1229205013981	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
1229205013982	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
1229205013983	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
1229205013984	active site
1229205013985	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1229205013986	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
1229205013987	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
1229205013988	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
1229205013989	trimer interface [polypeptide binding]; other site
1229205013990	active site
1229205013991	UDP-GlcNAc binding site [chemical binding]; other site
1229205013992	lipid binding site [chemical binding]; lipid-binding site
1229205013993	periplasmic chaperone; Provisional; Region: PRK10780
1229205013994	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
1229205013995	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
1229205013996	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1229205013997	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1229205013998	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1229205013999	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1229205014000	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1229205014001	Surface antigen; Region: Bac_surface_Ag; pfam01103
1229205014002	zinc metallopeptidase RseP; Provisional; Region: PRK10779
1229205014003	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1229205014004	active site
1229205014005	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1229205014006	protein binding site [polypeptide binding]; other site
1229205014007	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1229205014008	putative substrate binding region [chemical binding]; other site
1229205014009	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
1229205014010	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1229205014011	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1229205014012	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1229205014013	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1229205014014	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
1229205014015	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1229205014016	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
1229205014017	catalytic residue [active]
1229205014018	putative FPP diphosphate  binding site; other site
1229205014019	putative FPP binding hydrophobic cleft; other site
1229205014020	dimer interface [polypeptide binding]; other site
1229205014021	putative IPP diphosphate binding site; other site
1229205014022	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1229205014023	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1229205014024	hinge region; other site
1229205014025	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1229205014026	putative nucleotide binding site [chemical binding]; other site
1229205014027	uridine monophosphate binding site [chemical binding]; other site
1229205014028	homohexameric interface [polypeptide binding]; other site
1229205014029	elongation factor Ts; Provisional; Region: tsf; PRK09377
1229205014030	UBA/TS-N domain; Region: UBA; pfam00627
1229205014031	Elongation factor TS; Region: EF_TS; pfam00889
1229205014032	Elongation factor TS; Region: EF_TS; pfam00889
1229205014033	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1229205014034	rRNA interaction site [nucleotide binding]; other site
1229205014035	S8 interaction site; other site
1229205014036	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1229205014037	active site
1229205014038	PII uridylyl-transferase; Provisional; Region: PRK03059
1229205014039	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1229205014040	metal binding triad; other site
1229205014041	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1229205014042	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1229205014043	Zn2+ binding site [ion binding]; other site
1229205014044	Mg2+ binding site [ion binding]; other site
1229205014045	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
1229205014046	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
1229205014047	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1229205014048	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1229205014049	RNA binding surface [nucleotide binding]; other site
1229205014050	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
1229205014051	active site
1229205014052	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1229205014053	active site
1229205014054	catalytic residues [active]
1229205014055	metal binding site [ion binding]; metal-binding site
1229205014056	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1229205014057	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1229205014058	nucleotide binding pocket [chemical binding]; other site
1229205014059	K-X-D-G motif; other site
1229205014060	catalytic site [active]
1229205014061	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1229205014062	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1229205014063	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1229205014064	Dimer interface [polypeptide binding]; other site
1229205014065	BRCT sequence motif; other site
1229205014066	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038
1229205014067	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1229205014068	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1229205014069	Walker A/P-loop; other site
1229205014070	ATP binding site [chemical binding]; other site
1229205014071	Q-loop/lid; other site
1229205014072	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1229205014073	Q-loop/lid; other site
1229205014074	ABC transporter signature motif; other site
1229205014075	Walker B; other site
1229205014076	D-loop; other site
1229205014077	H-loop/switch region; other site
1229205014078	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1229205014079	EamA-like transporter family; Region: EamA; pfam00892
1229205014080	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
1229205014081	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229205014082	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205014083	homodimer interface [polypeptide binding]; other site
1229205014084	catalytic residue [active]
1229205014085	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
1229205014086	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
1229205014087	trimer interface [polypeptide binding]; other site
1229205014088	active site
1229205014089	substrate binding site [chemical binding]; other site
1229205014090	CoA binding site [chemical binding]; other site
1229205014091	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
1229205014092	ArsC family; Region: ArsC; pfam03960
1229205014093	putative catalytic residues [active]
1229205014094	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
1229205014095	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
1229205014096	metal binding site [ion binding]; metal-binding site
1229205014097	dimer interface [polypeptide binding]; other site
1229205014098	HemK family putative methylases; Region: hemK_fam; TIGR00536
1229205014099	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229205014100	S-adenosylmethionine binding site [chemical binding]; other site
1229205014101	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
1229205014102	Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155
1229205014103	putative active site [active]
1229205014104	catalytic site [active]
1229205014105	Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161
1229205014106	putative active site [active]
1229205014107	catalytic site [active]
1229205014108	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1229205014109	catalytic residues [active]
1229205014110	dimer interface [polypeptide binding]; other site
1229205014111	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
1229205014112	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1229205014113	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1229205014114	ABC transporter; Region: ABC_tran_2; pfam12848
1229205014115	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1229205014116	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1229205014117	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1229205014118	Protein of unknown function (DUF2866); Region: DUF2866; pfam11065
1229205014119	DNA repair protein RadA; Provisional; Region: PRK11823
1229205014120	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
1229205014121	Walker A motif/ATP binding site; other site
1229205014122	ATP binding site [chemical binding]; other site
1229205014123	Walker B motif; other site
1229205014124	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1229205014125	alanine racemase; Reviewed; Region: alr; PRK00053
1229205014126	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
1229205014127	active site
1229205014128	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1229205014129	substrate binding site [chemical binding]; other site
1229205014130	catalytic residues [active]
1229205014131	dimer interface [polypeptide binding]; other site
1229205014132	lysophospholipid transporter LplT; Provisional; Region: PRK11195
1229205014133	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1229205014134	dimer interface [polypeptide binding]; other site
1229205014135	substrate binding site [chemical binding]; other site
1229205014136	ATP binding site [chemical binding]; other site
1229205014137	Domain of unknown function (DUF1853); Region: DUF1853; pfam08907
1229205014138	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
1229205014139	Fe-S cluster binding site [ion binding]; other site
1229205014140	active site
1229205014141	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1229205014142	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1229205014143	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1229205014144	Glycoprotease family; Region: Peptidase_M22; pfam00814
1229205014145	Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221
1229205014146	acyl-CoA binding pocket [chemical binding]; other site
1229205014147	CoA binding site [chemical binding]; other site
1229205014148	helicase 45; Provisional; Region: PTZ00424
1229205014149	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1229205014150	ATP binding site [chemical binding]; other site
1229205014151	Mg++ binding site [ion binding]; other site
1229205014152	motif III; other site
1229205014153	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1229205014154	nucleotide binding region [chemical binding]; other site
1229205014155	ATP-binding site [chemical binding]; other site
1229205014156	isocitrate lyase; Provisional; Region: PRK15063
1229205014157	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1229205014158	tetramer interface [polypeptide binding]; other site
1229205014159	active site
1229205014160	Mg2+/Mn2+ binding site [ion binding]; other site
1229205014161	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1229205014162	Ligand Binding Site [chemical binding]; other site
1229205014163	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205014164	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205014165	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1229205014166	putative effector binding pocket; other site
1229205014167	dimerization interface [polypeptide binding]; other site
1229205014168	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
1229205014169	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229205014170	motif II; other site
1229205014171	malate synthase A; Region: malate_syn_A; TIGR01344
1229205014172	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
1229205014173	active site
1229205014174	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1229205014175	putative active site pocket [active]
1229205014176	dimerization interface [polypeptide binding]; other site
1229205014177	putative catalytic residue [active]
1229205014178	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1229205014179	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1229205014180	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205014181	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205014182	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229205014183	Coenzyme A binding pocket [chemical binding]; other site
1229205014184	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1229205014185	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1229205014186	active site
1229205014187	HIGH motif; other site
1229205014188	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1229205014189	active site
1229205014190	KMSKS motif; other site
1229205014191	hypothetical protein; Provisional; Region: PRK10279
1229205014192	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
1229205014193	nucleophile elbow; other site
1229205014194	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1229205014195	NlpC/P60 family; Region: NLPC_P60; pfam00877
1229205014196	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
1229205014197	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1229205014198	Walker A/P-loop; other site
1229205014199	ATP binding site [chemical binding]; other site
1229205014200	Q-loop/lid; other site
1229205014201	ABC transporter signature motif; other site
1229205014202	Walker B; other site
1229205014203	D-loop; other site
1229205014204	H-loop/switch region; other site
1229205014205	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1229205014206	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1229205014207	Walker A/P-loop; other site
1229205014208	ATP binding site [chemical binding]; other site
1229205014209	Q-loop/lid; other site
1229205014210	ABC transporter signature motif; other site
1229205014211	Walker B; other site
1229205014212	D-loop; other site
1229205014213	H-loop/switch region; other site
1229205014214	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1229205014215	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1229205014216	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
1229205014217	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205014218	dimer interface [polypeptide binding]; other site
1229205014219	conserved gate region; other site
1229205014220	putative PBP binding loops; other site
1229205014221	ABC-ATPase subunit interface; other site
1229205014222	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
1229205014223	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205014224	dimer interface [polypeptide binding]; other site
1229205014225	conserved gate region; other site
1229205014226	putative PBP binding loops; other site
1229205014227	ABC-ATPase subunit interface; other site
1229205014228	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1229205014229	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
1229205014230	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205014231	D-galactonate transporter; Region: 2A0114; TIGR00893
1229205014232	putative substrate translocation pore; other site
1229205014233	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
1229205014234	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
1229205014235	Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599
1229205014236	putative active site [active]
1229205014237	putative catalytic site [active]
1229205014238	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205014239	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205014240	trimer interface [polypeptide binding]; other site
1229205014241	eyelet of channel; other site
1229205014242	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1229205014243	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205014244	DNA-binding site [nucleotide binding]; DNA binding site
1229205014245	UTRA domain; Region: UTRA; pfam07702
1229205014246	putative oxidoreductase; Provisional; Region: PRK08275
1229205014247	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1229205014248	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
1229205014249	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1229205014250	HEAT repeats; Region: HEAT_2; pfam13646
1229205014251	HEAT repeats; Region: HEAT_2; pfam13646
1229205014252	Protein of unknown function (DUF971); Region: DUF971; pfam06155
1229205014253	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1229205014254	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229205014255	S-adenosylmethionine binding site [chemical binding]; other site
1229205014256	aspartate kinase; Reviewed; Region: PRK06635
1229205014257	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
1229205014258	putative nucleotide binding site [chemical binding]; other site
1229205014259	putative catalytic residues [active]
1229205014260	putative Mg ion binding site [ion binding]; other site
1229205014261	putative aspartate binding site [chemical binding]; other site
1229205014262	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
1229205014263	putative allosteric regulatory site; other site
1229205014264	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
1229205014265	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1229205014266	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1229205014267	Ligand Binding Site [chemical binding]; other site
1229205014268	TilS substrate binding domain; Region: TilS; pfam09179
1229205014269	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
1229205014270	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
1229205014271	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
1229205014272	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1229205014273	endonuclease III; Region: ENDO3c; smart00478
1229205014274	minor groove reading motif; other site
1229205014275	helix-hairpin-helix signature motif; other site
1229205014276	substrate binding pocket [chemical binding]; other site
1229205014277	active site
1229205014278	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1229205014279	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1229205014280	active site
1229205014281	HIGH motif; other site
1229205014282	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1229205014283	KMSKS motif; other site
1229205014284	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
1229205014285	tRNA binding surface [nucleotide binding]; other site
1229205014286	anticodon binding site; other site
1229205014287	TPR repeat; Region: TPR_11; pfam13414
1229205014288	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229205014289	binding surface
1229205014290	TPR motif; other site
1229205014291	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1229205014292	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
1229205014293	substrate binding site [chemical binding]; other site
1229205014294	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
1229205014295	substrate binding site [chemical binding]; other site
1229205014296	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
1229205014297	putative active site [active]
1229205014298	putative metal binding site [ion binding]; other site
1229205014299	serine O-acetyltransferase; Region: cysE; TIGR01172
1229205014300	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1229205014301	trimer interface [polypeptide binding]; other site
1229205014302	active site
1229205014303	substrate binding site [chemical binding]; other site
1229205014304	CoA binding site [chemical binding]; other site
1229205014305	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
1229205014306	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
1229205014307	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1229205014308	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
1229205014309	active site
1229205014310	dimerization interface [polypeptide binding]; other site
1229205014311	lysophospholipid transporter LplT; Provisional; Region: PRK11195
1229205014312	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1229205014313	MutS domain I; Region: MutS_I; pfam01624
1229205014314	MutS domain II; Region: MutS_II; pfam05188
1229205014315	MutS domain III; Region: MutS_III; pfam05192
1229205014316	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
1229205014317	Walker A/P-loop; other site
1229205014318	ATP binding site [chemical binding]; other site
1229205014319	Q-loop/lid; other site
1229205014320	ABC transporter signature motif; other site
1229205014321	Walker B; other site
1229205014322	D-loop; other site
1229205014323	H-loop/switch region; other site
1229205014324	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
1229205014325	Uncharacterized conserved protein [Function unknown]; Region: COG2850
1229205014326	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1229205014327	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
1229205014328	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1229205014329	DEAD_2; Region: DEAD_2; pfam06733
1229205014330	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1229205014331	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1229205014332	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1229205014333	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1229205014334	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
1229205014335	RNA binding site [nucleotide binding]; other site
1229205014336	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
1229205014337	potassium uptake protein; Region: kup; TIGR00794
1229205014338	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236
1229205014339	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1229205014340	active site
1229205014341	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1229205014342	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1229205014343	GDP-binding site [chemical binding]; other site
1229205014344	ACT binding site; other site
1229205014345	IMP binding site; other site
1229205014346	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
1229205014347	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1229205014348	dimer interface [polypeptide binding]; other site
1229205014349	motif 1; other site
1229205014350	active site
1229205014351	motif 2; other site
1229205014352	motif 3; other site
1229205014353	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1229205014354	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
1229205014355	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
1229205014356	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
1229205014357	HflK protein; Region: hflK; TIGR01933
1229205014358	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
1229205014359	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1229205014360	HflX GTPase family; Region: HflX; cd01878
1229205014361	G1 box; other site
1229205014362	GTP/Mg2+ binding site [chemical binding]; other site
1229205014363	Switch I region; other site
1229205014364	G2 box; other site
1229205014365	G3 box; other site
1229205014366	Switch II region; other site
1229205014367	G4 box; other site
1229205014368	G5 box; other site
1229205014369	bacterial Hfq-like; Region: Hfq; cd01716
1229205014370	hexamer interface [polypeptide binding]; other site
1229205014371	Sm1 motif; other site
1229205014372	RNA binding site [nucleotide binding]; other site
1229205014373	Sm2 motif; other site
1229205014374	GTP-binding protein Der; Reviewed; Region: PRK00093
1229205014375	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1229205014376	G1 box; other site
1229205014377	GTP/Mg2+ binding site [chemical binding]; other site
1229205014378	Switch I region; other site
1229205014379	G2 box; other site
1229205014380	Switch II region; other site
1229205014381	G3 box; other site
1229205014382	G4 box; other site
1229205014383	G5 box; other site
1229205014384	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1229205014385	G1 box; other site
1229205014386	GTP/Mg2+ binding site [chemical binding]; other site
1229205014387	Switch I region; other site
1229205014388	G2 box; other site
1229205014389	G3 box; other site
1229205014390	Switch II region; other site
1229205014391	G4 box; other site
1229205014392	G5 box; other site
1229205014393	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
1229205014394	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
1229205014395	Trp docking motif [polypeptide binding]; other site
1229205014396	active site
1229205014397	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
1229205014398	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
1229205014399	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1229205014400	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1229205014401	dimer interface [polypeptide binding]; other site
1229205014402	motif 1; other site
1229205014403	active site
1229205014404	motif 2; other site
1229205014405	motif 3; other site
1229205014406	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1229205014407	anticodon binding site; other site
1229205014408	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1229205014409	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
1229205014410	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1229205014411	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229205014412	non-specific DNA binding site [nucleotide binding]; other site
1229205014413	salt bridge; other site
1229205014414	sequence-specific DNA binding site [nucleotide binding]; other site
1229205014415	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
1229205014416	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
1229205014417	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1229205014418	FeS/SAM binding site; other site
1229205014419	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1229205014420	active site
1229205014421	multimer interface [polypeptide binding]; other site
1229205014422	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1229205014423	YccA-like proteins; Region: YccA_like; cd10433
1229205014424	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
1229205014425	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
1229205014426	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1229205014427	dihydrodipicolinate synthase; Region: dapA; TIGR00674
1229205014428	dimer interface [polypeptide binding]; other site
1229205014429	active site
1229205014430	catalytic residue [active]
1229205014431	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229205014432	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1229205014433	active site
1229205014434	HIGH motif; other site
1229205014435	dimer interface [polypeptide binding]; other site
1229205014436	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1229205014437	active site
1229205014438	KMSKS motif; other site
1229205014439	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
1229205014440	Peptidase family M50; Region: Peptidase_M50; pfam02163
1229205014441	active site
1229205014442	putative substrate binding region [chemical binding]; other site
1229205014443	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
1229205014444	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
1229205014445	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
1229205014446	active site
1229205014447	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
1229205014448	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1229205014449	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1229205014450	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
1229205014451	dinuclear metal binding motif [ion binding]; other site
1229205014452	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1229205014453	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1229205014454	trimer interface [polypeptide binding]; other site
1229205014455	putative metal binding site [ion binding]; other site
1229205014456	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
1229205014457	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
1229205014458	dimerization interface [polypeptide binding]; other site
1229205014459	domain crossover interface; other site
1229205014460	redox-dependent activation switch; other site
1229205014461	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
1229205014462	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
1229205014463	enolase; Provisional; Region: eno; PRK00077
1229205014464	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1229205014465	dimer interface [polypeptide binding]; other site
1229205014466	metal binding site [ion binding]; metal-binding site
1229205014467	substrate binding pocket [chemical binding]; other site
1229205014468	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
1229205014469	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1229205014470	CTP synthetase; Validated; Region: pyrG; PRK05380
1229205014471	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1229205014472	Catalytic site [active]
1229205014473	active site
1229205014474	UTP binding site [chemical binding]; other site
1229205014475	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1229205014476	active site
1229205014477	putative oxyanion hole; other site
1229205014478	catalytic triad [active]
1229205014479	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1229205014480	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1229205014481	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
1229205014482	Competence protein; Region: Competence; pfam03772
1229205014483	Competence protein; Region: Competence; pfam03772
1229205014484	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1229205014485	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1229205014486	active site
1229205014487	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
1229205014488	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1229205014489	Walker A/P-loop; other site
1229205014490	ATP binding site [chemical binding]; other site
1229205014491	Q-loop/lid; other site
1229205014492	ABC transporter signature motif; other site
1229205014493	Walker B; other site
1229205014494	D-loop; other site
1229205014495	H-loop/switch region; other site
1229205014496	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
1229205014497	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1229205014498	FtsX-like permease family; Region: FtsX; pfam02687
1229205014499	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255
1229205014500	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
1229205014501	DHH family; Region: DHH; pfam01368
1229205014502	DHHA1 domain; Region: DHHA1; pfam02272
1229205014503	peptide chain release factor 2; Validated; Region: prfB; PRK00578
1229205014504	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1229205014505	RF-1 domain; Region: RF-1; pfam00472
1229205014506	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1229205014507	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1229205014508	dimer interface [polypeptide binding]; other site
1229205014509	putative anticodon binding site; other site
1229205014510	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1229205014511	motif 1; other site
1229205014512	active site
1229205014513	motif 2; other site
1229205014514	motif 3; other site
1229205014515	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1229205014516	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1229205014517	catalytic loop [active]
1229205014518	iron binding site [ion binding]; other site
1229205014519	chaperone protein HscA; Provisional; Region: hscA; PRK05183
1229205014520	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
1229205014521	nucleotide binding site [chemical binding]; other site
1229205014522	putative NEF/HSP70 interaction site [polypeptide binding]; other site
1229205014523	SBD interface [polypeptide binding]; other site
1229205014524	co-chaperone HscB; Provisional; Region: hscB; PRK03578
1229205014525	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1229205014526	HSP70 interaction site [polypeptide binding]; other site
1229205014527	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
1229205014528	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
1229205014529	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1229205014530	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1229205014531	trimerization site [polypeptide binding]; other site
1229205014532	active site
1229205014533	cysteine desulfurase; Provisional; Region: PRK14012
1229205014534	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1229205014535	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1229205014536	catalytic residue [active]
1229205014537	Predicted transcriptional regulator [Transcription]; Region: COG1959
1229205014538	iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010
1229205014539	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1229205014540	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1229205014541	active site
1229205014542	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
1229205014543	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
1229205014544	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1229205014545	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
1229205014546	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1229205014547	Cysteine-rich domain; Region: CCG; pfam02754
1229205014548	Cysteine-rich domain; Region: CCG; pfam02754
1229205014549	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1229205014550	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1229205014551	Bacterial transcriptional regulator; Region: IclR; pfam01614
1229205014552	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1229205014553	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1229205014554	Phasin protein; Region: Phasin_2; pfam09361
1229205014555	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1229205014556	E3 interaction surface; other site
1229205014557	lipoyl attachment site [posttranslational modification]; other site
1229205014558	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
1229205014559	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1229205014560	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1229205014561	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1229205014562	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1229205014563	E3 interaction surface; other site
1229205014564	lipoyl attachment site [posttranslational modification]; other site
1229205014565	e3 binding domain; Region: E3_binding; pfam02817
1229205014566	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1229205014567	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
1229205014568	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
1229205014569	dimer interface [polypeptide binding]; other site
1229205014570	TPP-binding site [chemical binding]; other site
1229205014571	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
1229205014572	PAS domain S-box; Region: sensory_box; TIGR00229
1229205014573	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1229205014574	putative active site [active]
1229205014575	heme pocket [chemical binding]; other site
1229205014576	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1229205014577	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205014578	dimer interface [polypeptide binding]; other site
1229205014579	phosphorylation site [posttranslational modification]
1229205014580	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205014581	ATP binding site [chemical binding]; other site
1229205014582	Mg2+ binding site [ion binding]; other site
1229205014583	G-X-G motif; other site
1229205014584	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
1229205014585	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205014586	active site
1229205014587	phosphorylation site [posttranslational modification]
1229205014588	intermolecular recognition site; other site
1229205014589	dimerization interface [polypeptide binding]; other site
1229205014590	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1229205014591	DNA binding residues [nucleotide binding]
1229205014592	dimerization interface [polypeptide binding]; other site
1229205014593	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189
1229205014594	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1229205014595	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1229205014596	homodimer interface [polypeptide binding]; other site
1229205014597	NADP binding site [chemical binding]; other site
1229205014598	substrate binding site [chemical binding]; other site
1229205014599	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1229205014600	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
1229205014601	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
1229205014602	active site
1229205014603	Zn binding site [ion binding]; other site
1229205014604	cytosine deaminase; Validated; Region: PRK07572
1229205014605	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
1229205014606	active site
1229205014607	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
1229205014608	aspartate racemase; Region: asp_race; TIGR00035
1229205014609	Domain of unknown function (DUF4285); Region: DUF4285; pfam14113
1229205014610	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
1229205014611	putative catalytic site [active]
1229205014612	putative phosphate binding site [ion binding]; other site
1229205014613	active site
1229205014614	metal binding site A [ion binding]; metal-binding site
1229205014615	DNA binding site [nucleotide binding]
1229205014616	putative AP binding site [nucleotide binding]; other site
1229205014617	putative metal binding site B [ion binding]; other site
1229205014618	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
1229205014619	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1229205014620	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
1229205014621	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205014622	active site
1229205014623	phosphorylation site [posttranslational modification]
1229205014624	intermolecular recognition site; other site
1229205014625	dimerization interface [polypeptide binding]; other site
1229205014626	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205014627	Walker A motif; other site
1229205014628	ATP binding site [chemical binding]; other site
1229205014629	Walker B motif; other site
1229205014630	arginine finger; other site
1229205014631	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1229205014632	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1229205014633	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205014634	dimer interface [polypeptide binding]; other site
1229205014635	phosphorylation site [posttranslational modification]
1229205014636	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205014637	ATP binding site [chemical binding]; other site
1229205014638	Mg2+ binding site [ion binding]; other site
1229205014639	G-X-G motif; other site
1229205014640	glutamine synthetase; Provisional; Region: glnA; PRK09469
1229205014641	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1229205014642	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1229205014643	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
1229205014644	active site residue [active]
1229205014645	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
1229205014646	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
1229205014647	putative MPT binding site; other site
1229205014648	Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264
1229205014649	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
1229205014650	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
1229205014651	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
1229205014652	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1229205014653	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
1229205014654	trimer interface [polypeptide binding]; other site
1229205014655	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
1229205014656	trimer interface [polypeptide binding]; other site
1229205014657	Haemagglutinin; Region: HIM; pfam05662
1229205014658	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
1229205014659	trimer interface [polypeptide binding]; other site
1229205014660	Haemagglutinin; Region: HIM; pfam05662
1229205014661	YadA-like C-terminal region; Region: YadA; pfam03895
1229205014662	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
1229205014663	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1229205014664	ATP binding site [chemical binding]; other site
1229205014665	putative Mg++ binding site [ion binding]; other site
1229205014666	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1229205014667	nucleotide binding region [chemical binding]; other site
1229205014668	ATP-binding site [chemical binding]; other site
1229205014669	Helicase associated domain (HA2); Region: HA2; pfam04408
1229205014670	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
1229205014671	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
1229205014672	N-acetylglutamate synthase; Validated; Region: PRK05279
1229205014673	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
1229205014674	putative feedback inhibition sensing region; other site
1229205014675	putative nucleotide binding site [chemical binding]; other site
1229205014676	putative substrate binding site [chemical binding]; other site
1229205014677	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229205014678	Coenzyme A binding pocket [chemical binding]; other site
1229205014679	oxidative damage protection protein; Provisional; Region: PRK05408
1229205014680	proline/glycine betaine transporter; Provisional; Region: PRK10642
1229205014681	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205014682	putative substrate translocation pore; other site
1229205014683	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
1229205014684	active site
1229205014685	metal binding site [ion binding]; metal-binding site
1229205014686	homotetramer interface [polypeptide binding]; other site
1229205014687	Predicted integral membrane protein [Function unknown]; Region: COG3548
1229205014688	mercuric reductase; Validated; Region: PRK06370
1229205014689	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1229205014690	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1229205014691	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1229205014692	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1229205014693	GAF domain; Region: GAF; pfam01590
1229205014694	PAS domain S-box; Region: sensory_box; TIGR00229
1229205014695	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1229205014696	putative active site [active]
1229205014697	heme pocket [chemical binding]; other site
1229205014698	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1229205014699	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1229205014700	metal binding site [ion binding]; metal-binding site
1229205014701	active site
1229205014702	I-site; other site
1229205014703	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1229205014704	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
1229205014705	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1229205014706	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1229205014707	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205014708	DNA-binding site [nucleotide binding]; DNA binding site
1229205014709	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229205014710	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205014711	homodimer interface [polypeptide binding]; other site
1229205014712	catalytic residue [active]
1229205014713	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
1229205014714	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
1229205014715	putative molybdopterin cofactor binding site [chemical binding]; other site
1229205014716	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
1229205014717	putative molybdopterin cofactor binding site; other site
1229205014718	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
1229205014719	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1229205014720	Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324
1229205014721	putative active site pocket [active]
1229205014722	metal binding site [ion binding]; metal-binding site
1229205014723	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310
1229205014724	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1229205014725	putative ligand binding site [chemical binding]; other site
1229205014726	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1229205014727	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1229205014728	TM-ABC transporter signature motif; other site
1229205014729	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1229205014730	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1229205014731	Walker A/P-loop; other site
1229205014732	ATP binding site [chemical binding]; other site
1229205014733	Q-loop/lid; other site
1229205014734	ABC transporter signature motif; other site
1229205014735	Walker B; other site
1229205014736	D-loop; other site
1229205014737	H-loop/switch region; other site
1229205014738	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1229205014739	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1229205014740	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1229205014741	DNA binding site [nucleotide binding]
1229205014742	domain linker motif; other site
1229205014743	Ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_2; cd06282
1229205014744	putative dimerization interface [polypeptide binding]; other site
1229205014745	putative ligand binding site [chemical binding]; other site
1229205014746	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1229205014747	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1229205014748	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1229205014749	dimer interface [polypeptide binding]; other site
1229205014750	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1229205014751	conserved gate region; other site
1229205014752	ABC-ATPase subunit interface; other site
1229205014753	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1229205014754	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205014755	dimer interface [polypeptide binding]; other site
1229205014756	conserved gate region; other site
1229205014757	putative PBP binding loops; other site
1229205014758	ABC-ATPase subunit interface; other site
1229205014759	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1229205014760	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229205014761	Walker A/P-loop; other site
1229205014762	ATP binding site [chemical binding]; other site
1229205014763	Q-loop/lid; other site
1229205014764	ABC transporter signature motif; other site
1229205014765	Walker B; other site
1229205014766	D-loop; other site
1229205014767	H-loop/switch region; other site
1229205014768	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
1229205014769	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1229205014770	active site
1229205014771	metal binding site [ion binding]; metal-binding site
1229205014772	hexamer interface [polypeptide binding]; other site
1229205014773	Protein of unknown function (DUF2569); Region: DUF2569; pfam10754
1229205014774	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1229205014775	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205014776	Response regulator receiver domain; Region: Response_reg; pfam00072
1229205014777	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205014778	active site
1229205014779	phosphorylation site [posttranslational modification]
1229205014780	intermolecular recognition site; other site
1229205014781	dimerization interface [polypeptide binding]; other site
1229205014782	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205014783	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1229205014784	active site
1229205014785	phosphorylation site [posttranslational modification]
1229205014786	intermolecular recognition site; other site
1229205014787	dimerization interface [polypeptide binding]; other site
1229205014788	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1229205014789	DNA binding residues [nucleotide binding]
1229205014790	dimerization interface [polypeptide binding]; other site
1229205014791	Ferritin-like domain; Region: Ferritin; pfam00210
1229205014792	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
1229205014793	dinuclear metal binding motif [ion binding]; other site
1229205014794	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1229205014795	Histidine kinase; Region: HisKA_3; pfam07730
1229205014796	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205014797	ATP binding site [chemical binding]; other site
1229205014798	Mg2+ binding site [ion binding]; other site
1229205014799	G-X-G motif; other site
1229205014800	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
1229205014801	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1229205014802	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
1229205014803	active site
1229205014804	FMN binding site [chemical binding]; other site
1229205014805	2,4-decadienoyl-CoA binding site; other site
1229205014806	catalytic residue [active]
1229205014807	4Fe-4S cluster binding site [ion binding]; other site
1229205014808	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
1229205014809	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1229205014810	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
1229205014811	EamA-like transporter family; Region: EamA; pfam00892
1229205014812	EamA-like transporter family; Region: EamA; pfam00892
1229205014813	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
1229205014814	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1229205014815	Moco binding site; other site
1229205014816	metal coordination site [ion binding]; other site
1229205014817	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
1229205014818	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
1229205014819	Protein of unknown function (DUF1223); Region: DUF1223; pfam06764
1229205014820	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
1229205014821	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1229205014822	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
1229205014823	ThiC-associated domain; Region: ThiC-associated; pfam13667
1229205014824	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
1229205014825	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
1229205014826	L-lactate permease; Region: Lactate_perm; cl00701
1229205014827	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1229205014828	EamA-like transporter family; Region: EamA; pfam00892
1229205014829	EamA-like transporter family; Region: EamA; pfam00892
1229205014830	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
1229205014831	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
1229205014832	Protein of unknown function (DUF2844); Region: DUF2844; pfam11005
1229205014833	Protein of unknown function (DUF3443); Region: DUF3443; pfam11925
1229205014834	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1229205014835	2-isopropylmalate synthase; Validated; Region: PRK03739
1229205014836	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
1229205014837	active site
1229205014838	catalytic residues [active]
1229205014839	metal binding site [ion binding]; metal-binding site
1229205014840	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1229205014841	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1229205014842	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1229205014843	Walker A/P-loop; other site
1229205014844	ATP binding site [chemical binding]; other site
1229205014845	Q-loop/lid; other site
1229205014846	ABC transporter signature motif; other site
1229205014847	Walker B; other site
1229205014848	D-loop; other site
1229205014849	H-loop/switch region; other site
1229205014850	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1229205014851	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205014852	dimer interface [polypeptide binding]; other site
1229205014853	conserved gate region; other site
1229205014854	putative PBP binding loops; other site
1229205014855	ABC-ATPase subunit interface; other site
1229205014856	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1229205014857	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229205014858	substrate binding pocket [chemical binding]; other site
1229205014859	membrane-bound complex binding site; other site
1229205014860	hinge residues; other site
1229205014861	phenylhydantoinase; Validated; Region: PRK08323
1229205014862	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
1229205014863	tetramer interface [polypeptide binding]; other site
1229205014864	active site
1229205014865	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485
1229205014866	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
1229205014867	Na binding site [ion binding]; other site
1229205014868	putative substrate binding site [chemical binding]; other site
1229205014869	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
1229205014870	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
1229205014871	homodimer interface [polypeptide binding]; other site
1229205014872	active site
1229205014873	FMN binding site [chemical binding]; other site
1229205014874	substrate binding site [chemical binding]; other site
1229205014875	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1229205014876	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
1229205014877	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1229205014878	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1229205014879	allantoate amidohydrolase; Reviewed; Region: PRK09290
1229205014880	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
1229205014881	active site
1229205014882	metal binding site [ion binding]; metal-binding site
1229205014883	dimer interface [polypeptide binding]; other site
1229205014884	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
1229205014885	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229205014886	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
1229205014887	benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224
1229205014888	4Fe-4S binding domain; Region: Fer4; pfam00037
1229205014889	4Fe-4S binding domain; Region: Fer4; pfam00037
1229205014890	These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208
1229205014891	dimerization interface [polypeptide binding]; other site
1229205014892	FAD binding pocket [chemical binding]; other site
1229205014893	FAD binding motif [chemical binding]; other site
1229205014894	catalytic residues [active]
1229205014895	NAD binding pocket [chemical binding]; other site
1229205014896	phosphate binding motif [ion binding]; other site
1229205014897	beta-alpha-beta structure motif; other site
1229205014898	benzoyl-CoA oxygenase, B subunit; Region: benzo_boxB; TIGR03225
1229205014899	benzoyl-CoA-dihydrodiol lyase; Provisional; Region: PRK08184
1229205014900	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1229205014901	substrate binding site [chemical binding]; other site
1229205014902	oxyanion hole (OAH) forming residues; other site
1229205014903	trimer interface [polypeptide binding]; other site
1229205014904	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1229205014905	substrate binding site [chemical binding]; other site
1229205014906	oxyanion hole (OAH) forming residues; other site
1229205014907	trimer interface [polypeptide binding]; other site
1229205014908	anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154
1229205014909	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229205014910	non-specific DNA binding site [nucleotide binding]; other site
1229205014911	salt bridge; other site
1229205014912	sequence-specific DNA binding site [nucleotide binding]; other site
1229205014913	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1229205014914	ADP binding site [chemical binding]; other site
1229205014915	magnesium binding site [ion binding]; other site
1229205014916	putative shikimate binding site; other site
1229205014917	aldehyde dehydrogenase; Provisional; Region: PRK11903
1229205014918	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1229205014919	NAD(P) binding site [chemical binding]; other site
1229205014920	catalytic residues [active]
1229205014921	benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262
1229205014922	Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Region: BCL_4HBCL; cd05959
1229205014923	dimer interface [polypeptide binding]; other site
1229205014924	acyl-activating enzyme (AAE) consensus motif; other site
1229205014925	putative active site [active]
1229205014926	putative AMP binding site [chemical binding]; other site
1229205014927	putative CoA binding site [chemical binding]; other site
1229205014928	chemical substrate binding site [chemical binding]; other site
1229205014929	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1229205014930	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
1229205014931	Phosphoesterase family; Region: Phosphoesterase; pfam04185
1229205014932	Domain of unknown function (DUF756); Region: DUF756; pfam05506
1229205014933	Domain of unknown function (DUF756); Region: DUF756; pfam05506
1229205014934	Cache domain; Region: Cache_1; pfam02743
1229205014935	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1229205014936	dimerization interface [polypeptide binding]; other site
1229205014937	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1229205014938	dimer interface [polypeptide binding]; other site
1229205014939	putative CheW interface [polypeptide binding]; other site
1229205014940	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205014941	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205014942	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1229205014943	putative effector binding pocket; other site
1229205014944	dimerization interface [polypeptide binding]; other site
1229205014945	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1229205014946	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
1229205014947	substrate binding site [chemical binding]; other site
1229205014948	oxyanion hole (OAH) forming residues; other site
1229205014949	trimer interface [polypeptide binding]; other site
1229205014950	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1229205014951	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1229205014952	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
1229205014953	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1229205014954	active site
1229205014955	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
1229205014956	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1229205014957	active site
1229205014958	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1229205014959	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
1229205014960	DNA binding residues [nucleotide binding]
1229205014961	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1229205014962	IHF dimer interface [polypeptide binding]; other site
1229205014963	IHF - DNA interface [nucleotide binding]; other site
1229205014964	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1229205014965	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1229205014966	putative tRNA-binding site [nucleotide binding]; other site
1229205014967	B3/4 domain; Region: B3_4; pfam03483
1229205014968	tRNA synthetase B5 domain; Region: B5; smart00874
1229205014969	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1229205014970	dimer interface [polypeptide binding]; other site
1229205014971	motif 1; other site
1229205014972	motif 3; other site
1229205014973	motif 2; other site
1229205014974	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
1229205014975	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1229205014976	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1229205014977	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1229205014978	dimer interface [polypeptide binding]; other site
1229205014979	motif 1; other site
1229205014980	active site
1229205014981	motif 2; other site
1229205014982	motif 3; other site
1229205014983	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1229205014984	23S rRNA binding site [nucleotide binding]; other site
1229205014985	L21 binding site [polypeptide binding]; other site
1229205014986	L13 binding site [polypeptide binding]; other site
1229205014987	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1229205014988	translation initiation factor IF-3; Region: infC; TIGR00168
1229205014989	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1229205014990	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1229205014991	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1229205014992	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
1229205014993	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1229205014994	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1229205014995	active site
1229205014996	dimer interface [polypeptide binding]; other site
1229205014997	motif 1; other site
1229205014998	motif 2; other site
1229205014999	motif 3; other site
1229205015000	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1229205015001	anticodon binding site; other site
1229205015002	HD domain; Region: HD_4; pfam13328
1229205015003	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1229205015004	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1229205015005	synthetase active site [active]
1229205015006	NTP binding site [chemical binding]; other site
1229205015007	metal binding site [ion binding]; metal-binding site
1229205015008	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1229205015009	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1229205015010	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
1229205015011	homotrimer interaction site [polypeptide binding]; other site
1229205015012	putative active site [active]
1229205015013	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1229205015014	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
1229205015015	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
1229205015016	PAS domain; Region: PAS_9; pfam13426
1229205015017	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1229205015018	putative active site [active]
1229205015019	heme pocket [chemical binding]; other site
1229205015020	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1229205015021	DNA binding residues [nucleotide binding]
1229205015022	dimerization interface [polypeptide binding]; other site
1229205015023	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1229205015024	active site
1229205015025	short chain dehydrogenase; Provisional; Region: PRK06949
1229205015026	classical (c) SDRs; Region: SDR_c; cd05233
1229205015027	NAD(P) binding site [chemical binding]; other site
1229205015028	active site
1229205015029	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
1229205015030	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1229205015031	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
1229205015032	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
1229205015033	TPR repeat; Region: TPR_11; pfam13414
1229205015034	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229205015035	TPR motif; other site
1229205015036	binding surface
1229205015037	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1229205015038	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1229205015039	Tetramer interface [polypeptide binding]; other site
1229205015040	active site
1229205015041	FMN-binding site [chemical binding]; other site
1229205015042	lysophospholipid transporter LplT; Provisional; Region: PRK11195
1229205015043	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205015044	putative substrate translocation pore; other site
1229205015045	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1229205015046	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1229205015047	putative acyl-acceptor binding pocket; other site
1229205015048	FOG: CBS domain [General function prediction only]; Region: COG0517
1229205015049	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_12; cd04625
1229205015050	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08134
1229205015051	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1229205015052	homodimer interface [polypeptide binding]; other site
1229205015053	substrate-cofactor binding pocket; other site
1229205015054	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205015055	catalytic residue [active]
1229205015056	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1229205015057	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1229205015058	Protein of unknown function (DUF962); Region: DUF962; cl01879
1229205015059	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
1229205015060	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1229205015061	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1229205015062	Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842
1229205015063	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1229205015064	FAD binding domain; Region: FAD_binding_4; pfam01565
1229205015065	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
1229205015066	Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404
1229205015067	putative active site [active]
1229205015068	putative metal binding site [ion binding]; other site
1229205015069	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205015070	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205015071	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1229205015072	putative effector binding pocket; other site
1229205015073	dimerization interface [polypeptide binding]; other site
1229205015074	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
1229205015075	Fusaric acid resistance protein family; Region: FUSC; pfam04632
1229205015076	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1229205015077	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1229205015078	HlyD family secretion protein; Region: HlyD_3; pfam13437
1229205015079	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1229205015080	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1229205015081	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1229205015082	dimer interface [polypeptide binding]; other site
1229205015083	putative CheW interface [polypeptide binding]; other site
1229205015084	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205015085	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229205015086	putative substrate translocation pore; other site
1229205015087	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
1229205015088	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1229205015089	acyl-activating enzyme (AAE) consensus motif; other site
1229205015090	AMP binding site [chemical binding]; other site
1229205015091	active site
1229205015092	CoA binding site [chemical binding]; other site
1229205015093	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
1229205015094	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
1229205015095	Part of AAA domain; Region: AAA_19; pfam13245
1229205015096	Family description; Region: UvrD_C_2; pfam13538
1229205015097	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1229205015098	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1229205015099	HIGH motif; other site
1229205015100	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1229205015101	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1229205015102	active site
1229205015103	KMSKS motif; other site
1229205015104	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1229205015105	tRNA binding surface [nucleotide binding]; other site
1229205015106	anticodon binding site; other site
1229205015107	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1229205015108	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1229205015109	tetramer interface; other site
1229205015110	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1229205015111	active site
1229205015112	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
1229205015113	CPxP  motif; other site
1229205015114	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1229205015115	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1229205015116	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1229205015117	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1229205015118	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1229205015119	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1229205015120	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1229205015121	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1229205015122	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1229205015123	putative active site [active]
1229205015124	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
1229205015125	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1229205015126	putative ligand binding site [chemical binding]; other site
1229205015127	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1229205015128	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1229205015129	TM-ABC transporter signature motif; other site
1229205015130	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1229205015131	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1229205015132	Walker A/P-loop; other site
1229205015133	ATP binding site [chemical binding]; other site
1229205015134	Q-loop/lid; other site
1229205015135	ABC transporter signature motif; other site
1229205015136	Walker B; other site
1229205015137	D-loop; other site
1229205015138	H-loop/switch region; other site
1229205015139	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1229205015140	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1229205015141	substrate binding site [chemical binding]; other site
1229205015142	ATP binding site [chemical binding]; other site
1229205015143	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
1229205015144	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892
1229205015145	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
1229205015146	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1229205015147	PYR/PP interface [polypeptide binding]; other site
1229205015148	dimer interface [polypeptide binding]; other site
1229205015149	TPP binding site [chemical binding]; other site
1229205015150	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1229205015151	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1229205015152	TPP-binding site [chemical binding]; other site
1229205015153	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1229205015154	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
1229205015155	KduI/IolB family; Region: KduI; pfam04962
1229205015156	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1229205015157	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1229205015158	Walker A/P-loop; other site
1229205015159	ATP binding site [chemical binding]; other site
1229205015160	Q-loop/lid; other site
1229205015161	ABC transporter signature motif; other site
1229205015162	Walker B; other site
1229205015163	D-loop; other site
1229205015164	H-loop/switch region; other site
1229205015165	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1229205015166	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1229205015167	Walker A/P-loop; other site
1229205015168	ATP binding site [chemical binding]; other site
1229205015169	Q-loop/lid; other site
1229205015170	ABC transporter signature motif; other site
1229205015171	Walker B; other site
1229205015172	D-loop; other site
1229205015173	H-loop/switch region; other site
1229205015174	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1229205015175	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1229205015176	TM-ABC transporter signature motif; other site
1229205015177	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1229205015178	TM-ABC transporter signature motif; other site
1229205015179	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1229205015180	active site
1229205015181	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
1229205015182	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1229205015183	nudix motif; other site
1229205015184	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
1229205015185	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
1229205015186	tetramer interface [polypeptide binding]; other site
1229205015187	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205015188	catalytic residue [active]
1229205015189	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
1229205015190	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205015191	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205015192	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
1229205015193	putative dimerization interface [polypeptide binding]; other site
1229205015194	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1229205015195	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1229205015196	motif 1; other site
1229205015197	active site
1229205015198	motif 2; other site
1229205015199	motif 3; other site
1229205015200	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1229205015201	DHHA1 domain; Region: DHHA1; pfam02272
1229205015202	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1229205015203	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1229205015204	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
1229205015205	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1229205015206	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1229205015207	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
1229205015208	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1229205015209	active site
1229205015210	HIGH motif; other site
1229205015211	nucleotide binding site [chemical binding]; other site
1229205015212	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
1229205015213	KMSKS motif; other site
1229205015214	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
1229205015215	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1229205015216	nudix motif; other site
1229205015217	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
1229205015218	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
1229205015219	acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397
1229205015220	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
1229205015221	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
1229205015222	active site
1229205015223	catalytic residues [active]
1229205015224	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1229205015225	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1229205015226	Peptidase family M23; Region: Peptidase_M23; pfam01551
1229205015227	Protein of unknown function (DUF2288); Region: DUF2288; pfam10052
1229205015228	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
1229205015229	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
1229205015230	Predicted chitinase [General function prediction only]; Region: COG3179
1229205015231	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1229205015232	catalytic core [active]
1229205015233	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
1229205015234	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
1229205015235	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1229205015236	polyphosphate kinase; Provisional; Region: PRK05443
1229205015237	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
1229205015238	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
1229205015239	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1229205015240	putative active site [active]
1229205015241	catalytic site [active]
1229205015242	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
1229205015243	putative domain interface [polypeptide binding]; other site
1229205015244	putative active site [active]
1229205015245	catalytic site [active]
1229205015246	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1229205015247	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1229205015248	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205015249	dimer interface [polypeptide binding]; other site
1229205015250	phosphorylation site [posttranslational modification]
1229205015251	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205015252	ATP binding site [chemical binding]; other site
1229205015253	Mg2+ binding site [ion binding]; other site
1229205015254	G-X-G motif; other site
1229205015255	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
1229205015256	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205015257	active site
1229205015258	phosphorylation site [posttranslational modification]
1229205015259	intermolecular recognition site; other site
1229205015260	dimerization interface [polypeptide binding]; other site
1229205015261	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229205015262	DNA binding site [nucleotide binding]
1229205015263	transcriptional regulator PhoU; Provisional; Region: PRK11115
1229205015264	PhoU domain; Region: PhoU; pfam01895
1229205015265	PhoU domain; Region: PhoU; pfam01895
1229205015266	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
1229205015267	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1229205015268	Walker A/P-loop; other site
1229205015269	ATP binding site [chemical binding]; other site
1229205015270	Q-loop/lid; other site
1229205015271	ABC transporter signature motif; other site
1229205015272	Walker B; other site
1229205015273	D-loop; other site
1229205015274	H-loop/switch region; other site
1229205015275	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
1229205015276	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205015277	dimer interface [polypeptide binding]; other site
1229205015278	conserved gate region; other site
1229205015279	putative PBP binding loops; other site
1229205015280	ABC-ATPase subunit interface; other site
1229205015281	phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275
1229205015282	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205015283	dimer interface [polypeptide binding]; other site
1229205015284	conserved gate region; other site
1229205015285	putative PBP binding loops; other site
1229205015286	ABC-ATPase subunit interface; other site
1229205015287	PBP superfamily domain; Region: PBP_like_2; cl17296
1229205015288	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
1229205015289	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1229205015290	active site
1229205015291	substrate binding site [chemical binding]; other site
1229205015292	metal binding site [ion binding]; metal-binding site
1229205015293	dihydropteroate synthase; Region: DHPS; TIGR01496
1229205015294	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1229205015295	substrate binding pocket [chemical binding]; other site
1229205015296	dimer interface [polypeptide binding]; other site
1229205015297	inhibitor binding site; inhibition site
1229205015298	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
1229205015299	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205015300	Walker A motif; other site
1229205015301	ATP binding site [chemical binding]; other site
1229205015302	Walker B motif; other site
1229205015303	arginine finger; other site
1229205015304	Peptidase family M41; Region: Peptidase_M41; pfam01434
1229205015305	FtsJ-like methyltransferase; Region: FtsJ; cl17430
1229205015306	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
1229205015307	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
1229205015308	Domain of unknown function (DUF4149); Region: DUF4149; pfam13664
1229205015309	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1229205015310	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1229205015311	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1229205015312	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1229205015313	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1229205015314	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1229205015315	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1229205015316	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1229205015317	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1229205015318	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1229205015319	IMP binding site; other site
1229205015320	dimer interface [polypeptide binding]; other site
1229205015321	interdomain contacts; other site
1229205015322	partial ornithine binding site; other site
1229205015323	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1229205015324	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1229205015325	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1229205015326	catalytic site [active]
1229205015327	subunit interface [polypeptide binding]; other site
1229205015328	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
1229205015329	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1229205015330	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1229205015331	catalytic residue [active]
1229205015332	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1229205015333	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1229205015334	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
1229205015335	Methyltransferase domain; Region: Methyltransf_11; pfam08241
1229205015336	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
1229205015337	RNA/DNA hybrid binding site [nucleotide binding]; other site
1229205015338	active site
1229205015339	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
1229205015340	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
1229205015341	active site
1229205015342	catalytic site [active]
1229205015343	substrate binding site [chemical binding]; other site
1229205015344	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1229205015345	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1229205015346	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1229205015347	Walker A/P-loop; other site
1229205015348	ATP binding site [chemical binding]; other site
1229205015349	Q-loop/lid; other site
1229205015350	ABC transporter signature motif; other site
1229205015351	Walker B; other site
1229205015352	D-loop; other site
1229205015353	H-loop/switch region; other site
1229205015354	Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980
1229205015355	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229205015356	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
1229205015357	putative ADP-binding pocket [chemical binding]; other site
1229205015358	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1229205015359	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1229205015360	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229205015361	Walker A/P-loop; other site
1229205015362	ATP binding site [chemical binding]; other site
1229205015363	Q-loop/lid; other site
1229205015364	ABC transporter signature motif; other site
1229205015365	Walker B; other site
1229205015366	D-loop; other site
1229205015367	H-loop/switch region; other site
1229205015368	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
1229205015369	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
1229205015370	active site
1229205015371	homotetramer interface [polypeptide binding]; other site
1229205015372	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229205015373	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
1229205015374	active site
1229205015375	motif I; other site
1229205015376	motif II; other site
1229205015377	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
1229205015378	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
1229205015379	Cu(I) binding site [ion binding]; other site
1229205015380	Protein of unknown function (DUF461); Region: DUF461; pfam04314
1229205015381	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
1229205015382	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1229205015383	Coenzyme A binding pocket [chemical binding]; other site
1229205015384	TraB family; Region: TraB; pfam01963
1229205015385	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
1229205015386	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1229205015387	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1229205015388	GIY-YIG motif/motif A; other site
1229205015389	active site
1229205015390	catalytic site [active]
1229205015391	putative DNA binding site [nucleotide binding]; other site
1229205015392	metal binding site [ion binding]; metal-binding site
1229205015393	UvrB/uvrC motif; Region: UVR; pfam02151
1229205015394	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1229205015395	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1229205015396	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394
1229205015397	Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093
1229205015398	elongation factor P; Validated; Region: PRK00529
1229205015399	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1229205015400	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1229205015401	RNA binding site [nucleotide binding]; other site
1229205015402	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1229205015403	RNA binding site [nucleotide binding]; other site
1229205015404	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1229205015405	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205015406	active site
1229205015407	phosphorylation site [posttranslational modification]
1229205015408	intermolecular recognition site; other site
1229205015409	dimerization interface [polypeptide binding]; other site
1229205015410	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205015411	Walker A motif; other site
1229205015412	ATP binding site [chemical binding]; other site
1229205015413	Walker B motif; other site
1229205015414	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1229205015415	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1229205015416	beta-hexosaminidase; Provisional; Region: PRK05337
1229205015417	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1229205015418	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
1229205015419	active site
1229205015420	hydrophilic channel; other site
1229205015421	dimerization interface [polypeptide binding]; other site
1229205015422	catalytic residues [active]
1229205015423	active site lid [active]
1229205015424	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
1229205015425	Recombination protein O N terminal; Region: RecO_N; pfam11967
1229205015426	Recombination protein O C terminal; Region: RecO_C; pfam02565
1229205015427	GTPase Era; Reviewed; Region: era; PRK00089
1229205015428	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1229205015429	G1 box; other site
1229205015430	GTP/Mg2+ binding site [chemical binding]; other site
1229205015431	Switch I region; other site
1229205015432	G2 box; other site
1229205015433	Switch II region; other site
1229205015434	G3 box; other site
1229205015435	G4 box; other site
1229205015436	G5 box; other site
1229205015437	KH domain; Region: KH_2; pfam07650
1229205015438	ribonuclease III; Reviewed; Region: PRK12372
1229205015439	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1229205015440	dimerization interface [polypeptide binding]; other site
1229205015441	active site
1229205015442	metal binding site [ion binding]; metal-binding site
1229205015443	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1229205015444	signal peptidase I; Provisional; Region: PRK10861
1229205015445	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1229205015446	Catalytic site [active]
1229205015447	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1229205015448	GTP-binding protein LepA; Provisional; Region: PRK05433
1229205015449	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1229205015450	G1 box; other site
1229205015451	putative GEF interaction site [polypeptide binding]; other site
1229205015452	GTP/Mg2+ binding site [chemical binding]; other site
1229205015453	Switch I region; other site
1229205015454	G2 box; other site
1229205015455	G3 box; other site
1229205015456	Switch II region; other site
1229205015457	G4 box; other site
1229205015458	G5 box; other site
1229205015459	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1229205015460	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1229205015461	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1229205015462	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
1229205015463	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
1229205015464	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1229205015465	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1229205015466	protein binding site [polypeptide binding]; other site
1229205015467	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1229205015468	protein binding site [polypeptide binding]; other site
1229205015469	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
1229205015470	anti-sigma E factor; Provisional; Region: rseB; PRK09455
1229205015471	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
1229205015472	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
1229205015473	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1229205015474	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1229205015475	DNA binding residues [nucleotide binding]
1229205015476	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
1229205015477	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1229205015478	dimer interface [polypeptide binding]; other site
1229205015479	active site
1229205015480	acyl carrier protein; Provisional; Region: acpP; PRK00982
1229205015481	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1229205015482	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
1229205015483	NAD(P) binding site [chemical binding]; other site
1229205015484	homotetramer interface [polypeptide binding]; other site
1229205015485	homodimer interface [polypeptide binding]; other site
1229205015486	active site
1229205015487	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1229205015488	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1229205015489	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1229205015490	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1229205015491	dimer interface [polypeptide binding]; other site
1229205015492	active site
1229205015493	CoA binding pocket [chemical binding]; other site
1229205015494	putative phosphate acyltransferase; Provisional; Region: PRK05331
1229205015495	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
1229205015496	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1229205015497	active site
1229205015498	dimer interface [polypeptide binding]; other site
1229205015499	Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649
1229205015500	putative SAM binding site [chemical binding]; other site
1229205015501	homodimer interface [polypeptide binding]; other site
1229205015502	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
1229205015503	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
1229205015504	tandem repeat interface [polypeptide binding]; other site
1229205015505	oligomer interface [polypeptide binding]; other site
1229205015506	active site residues [active]
1229205015507	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
1229205015508	iron-sulfur cluster [ion binding]; other site
1229205015509	[2Fe-2S] cluster binding site [ion binding]; other site
1229205015510	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1229205015511	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229205015512	motif II; other site
1229205015513	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
1229205015514	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1229205015515	RNA binding surface [nucleotide binding]; other site
1229205015516	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1229205015517	active site
1229205015518	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
1229205015519	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1229205015520	homodimer interface [polypeptide binding]; other site
1229205015521	oligonucleotide binding site [chemical binding]; other site
1229205015522	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
1229205015523	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1229205015524	FeS/SAM binding site; other site
1229205015525	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1229205015526	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
1229205015527	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1229205015528	GTP binding site; other site
1229205015529	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1229205015530	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
1229205015531	dimer interface [polypeptide binding]; other site
1229205015532	putative functional site; other site
1229205015533	putative MPT binding site; other site
1229205015534	RmuC family; Region: RmuC; pfam02646
1229205015535	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1229205015536	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
1229205015537	dimerization interface [polypeptide binding]; other site
1229205015538	ligand binding site [chemical binding]; other site
1229205015539	NADP binding site [chemical binding]; other site
1229205015540	catalytic site [active]
1229205015541	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
1229205015542	Uncharacterized conserved protein [Function unknown]; Region: COG1556
1229205015543	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
1229205015544	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
1229205015545	active site
1229205015546	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1229205015547	4Fe-4S binding domain; Region: Fer4; cl02805
1229205015548	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
1229205015549	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045
1229205015550	CreA protein; Region: CreA; pfam05981
1229205015551	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1229205015552	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205015553	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1229205015554	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205015555	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
1229205015556	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
1229205015557	Protein of unknown function (DUF4088); Region: DUF4088; pfam13317
1229205015558	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1229205015559	Part of AAA domain; Region: AAA_19; pfam13245
1229205015560	Family description; Region: UvrD_C_2; pfam13538
1229205015561	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
1229205015562	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1229205015563	RNA binding surface [nucleotide binding]; other site
1229205015564	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
1229205015565	multidrug efflux protein; Reviewed; Region: PRK01766
1229205015566	cation binding site [ion binding]; other site
1229205015567	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1229205015568	Sodium Bile acid symporter family; Region: SBF; pfam01758
1229205015569	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
1229205015570	PLD-like domain; Region: PLDc_2; pfam13091
1229205015571	putative active site [active]
1229205015572	catalytic site [active]
1229205015573	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
1229205015574	PLD-like domain; Region: PLDc_2; pfam13091
1229205015575	putative active site [active]
1229205015576	catalytic site [active]
1229205015577	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1229205015578	Class II fumarases; Region: Fumarase_classII; cd01362
1229205015579	active site
1229205015580	tetramer interface [polypeptide binding]; other site
1229205015581	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1229205015582	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1229205015583	conserved cys residue [active]
1229205015584	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1229205015585	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205015586	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205015587	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229205015588	putative substrate translocation pore; other site
1229205015589	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1229205015590	dimerization interface [polypeptide binding]; other site
1229205015591	putative DNA binding site [nucleotide binding]; other site
1229205015592	putative Zn2+ binding site [ion binding]; other site
1229205015593	thymidylate synthase; Provisional; Region: thyA; PRK13821
1229205015594	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1229205015595	dimerization interface [polypeptide binding]; other site
1229205015596	active site
1229205015597	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205015598	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1229205015599	Walker A motif; other site
1229205015600	ATP binding site [chemical binding]; other site
1229205015601	Walker B motif; other site
1229205015602	arginine finger; other site
1229205015603	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
1229205015604	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1229205015605	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1229205015606	folate binding site [chemical binding]; other site
1229205015607	NADP+ binding site [chemical binding]; other site
1229205015608	peptidase PmbA; Provisional; Region: PRK11040
1229205015609	hypothetical protein; Provisional; Region: PRK05255
1229205015610	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1229205015611	MPT binding site; other site
1229205015612	trimer interface [polypeptide binding]; other site
1229205015613	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1229205015614	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
1229205015615	catalytic site [active]
1229205015616	putative active site [active]
1229205015617	putative substrate binding site [chemical binding]; other site
1229205015618	dimer interface [polypeptide binding]; other site
1229205015619	Peptidase family M48; Region: Peptidase_M48; pfam01435
1229205015620	GTPase RsgA; Reviewed; Region: PRK00098
1229205015621	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
1229205015622	RNA binding site [nucleotide binding]; other site
1229205015623	homodimer interface [polypeptide binding]; other site
1229205015624	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1229205015625	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1229205015626	GTP/Mg2+ binding site [chemical binding]; other site
1229205015627	G4 box; other site
1229205015628	G5 box; other site
1229205015629	G1 box; other site
1229205015630	Switch I region; other site
1229205015631	G2 box; other site
1229205015632	G3 box; other site
1229205015633	Switch II region; other site
1229205015634	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
1229205015635	CobD/CbiB family protein; Provisional; Region: PRK07630
1229205015636	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
1229205015637	putative active site [active]
1229205015638	putative CoA binding site [chemical binding]; other site
1229205015639	nudix motif; other site
1229205015640	metal binding site [ion binding]; metal-binding site
1229205015641	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1229205015642	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1229205015643	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1229205015644	RimM N-terminal domain; Region: RimM; pfam01782
1229205015645	PRC-barrel domain; Region: PRC; pfam05239
1229205015646	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
1229205015647	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
1229205015648	Domain of unknown function (DUF373); Region: DUF373; cl12079
1229205015649	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
1229205015650	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1229205015651	FeS/SAM binding site; other site
1229205015652	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
1229205015653	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1229205015654	putative DNA binding site [nucleotide binding]; other site
1229205015655	putative Zn2+ binding site [ion binding]; other site
1229205015656	AsnC family; Region: AsnC_trans_reg; pfam01037
1229205015657	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
1229205015658	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
1229205015659	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
1229205015660	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1229205015661	active site
1229205015662	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
1229205015663	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1229205015664	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1229205015665	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1229205015666	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1229205015667	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1229205015668	Ligand binding site [chemical binding]; other site
1229205015669	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1229205015670	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1229205015671	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205015672	dimer interface [polypeptide binding]; other site
1229205015673	conserved gate region; other site
1229205015674	ABC-ATPase subunit interface; other site
1229205015675	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
1229205015676	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1229205015677	Walker A/P-loop; other site
1229205015678	ATP binding site [chemical binding]; other site
1229205015679	Q-loop/lid; other site
1229205015680	ABC transporter signature motif; other site
1229205015681	Walker B; other site
1229205015682	D-loop; other site
1229205015683	H-loop/switch region; other site
1229205015684	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
1229205015685	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1229205015686	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1229205015687	enoyl-CoA hydratase; Validated; Region: PRK08139
1229205015688	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1229205015689	substrate binding site [chemical binding]; other site
1229205015690	oxyanion hole (OAH) forming residues; other site
1229205015691	trimer interface [polypeptide binding]; other site
1229205015692	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
1229205015693	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
1229205015694	putative active site [active]
1229205015695	Zn binding site [ion binding]; other site
1229205015696	Transglycosylase SLT domain; Region: SLT_2; pfam13406
1229205015697	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1229205015698	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1229205015699	cysteine synthase B; Region: cysM; TIGR01138
1229205015700	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1229205015701	dimer interface [polypeptide binding]; other site
1229205015702	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205015703	catalytic residue [active]
1229205015704	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
1229205015705	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
1229205015706	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
1229205015707	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
1229205015708	NADP binding site [chemical binding]; other site
1229205015709	homopentamer interface [polypeptide binding]; other site
1229205015710	substrate binding site [chemical binding]; other site
1229205015711	active site
1229205015712	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
1229205015713	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
1229205015714	putative ribose interaction site [chemical binding]; other site
1229205015715	putative ADP binding site [chemical binding]; other site
1229205015716	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1229205015717	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1229205015718	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1229205015719	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1229205015720	tetratricopeptide repeat protein; Provisional; Region: PRK11788
1229205015721	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229205015722	binding surface
1229205015723	TPR motif; other site
1229205015724	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
1229205015725	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1229205015726	IHF dimer interface [polypeptide binding]; other site
1229205015727	IHF - DNA interface [nucleotide binding]; other site
1229205015728	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
1229205015729	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1229205015730	RNA binding site [nucleotide binding]; other site
1229205015731	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1229205015732	RNA binding site [nucleotide binding]; other site
1229205015733	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
1229205015734	RNA binding site [nucleotide binding]; other site
1229205015735	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
1229205015736	RNA binding site [nucleotide binding]; other site
1229205015737	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
1229205015738	RNA binding site [nucleotide binding]; other site
1229205015739	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
1229205015740	RNA binding site [nucleotide binding]; other site
1229205015741	cytidylate kinase; Provisional; Region: cmk; PRK00023
1229205015742	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1229205015743	CMP-binding site; other site
1229205015744	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1229205015745	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1229205015746	hinge; other site
1229205015747	active site
1229205015748	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
1229205015749	prephenate dehydrogenase; Validated; Region: PRK08507
1229205015750	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
1229205015751	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229205015752	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205015753	homodimer interface [polypeptide binding]; other site
1229205015754	catalytic residue [active]
1229205015755	Chorismate mutase type II; Region: CM_2; smart00830
1229205015756	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
1229205015757	Prephenate dehydratase; Region: PDT; pfam00800
1229205015758	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1229205015759	putative L-Phe binding site [chemical binding]; other site
1229205015760	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
1229205015761	homodimer interface [polypeptide binding]; other site
1229205015762	substrate-cofactor binding pocket; other site
1229205015763	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205015764	catalytic residue [active]
1229205015765	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
1229205015766	DNA gyrase subunit A; Validated; Region: PRK05560
1229205015767	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1229205015768	CAP-like domain; other site
1229205015769	active site
1229205015770	primary dimer interface [polypeptide binding]; other site
1229205015771	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1229205015772	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1229205015773	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1229205015774	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1229205015775	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1229205015776	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1229205015777	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1229205015778	ligand binding site [chemical binding]; other site
1229205015779	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
1229205015780	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229205015781	S-adenosylmethionine binding site [chemical binding]; other site
1229205015782	phosphoglycolate phosphatase; Provisional; Region: PRK13222
1229205015783	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229205015784	motif II; other site
1229205015785	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
1229205015786	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
1229205015787	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
1229205015788	putative active site [active]
1229205015789	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1229205015790	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1229205015791	Walker A/P-loop; other site
1229205015792	ATP binding site [chemical binding]; other site
1229205015793	Q-loop/lid; other site
1229205015794	ABC transporter signature motif; other site
1229205015795	Walker B; other site
1229205015796	D-loop; other site
1229205015797	H-loop/switch region; other site
1229205015798	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1229205015799	HlyD family secretion protein; Region: HlyD_3; pfam13437
1229205015800	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
1229205015801	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
1229205015802	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
1229205015803	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
1229205015804	PBP superfamily domain; Region: PBP_like; pfam12727
1229205015805	formate dehydrogenase subunit gamma; Validated; Region: PRK05988
1229205015806	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081
1229205015807	putative dimer interface [polypeptide binding]; other site
1229205015808	[2Fe-2S] cluster binding site [ion binding]; other site
1229205015809	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063
1229205015810	putative dimer interface [polypeptide binding]; other site
1229205015811	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
1229205015812	SLBB domain; Region: SLBB; pfam10531
1229205015813	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
1229205015814	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1229205015815	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
1229205015816	catalytic loop [active]
1229205015817	iron binding site [ion binding]; other site
1229205015818	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929
1229205015819	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
1229205015820	[4Fe-4S] binding site [ion binding]; other site
1229205015821	molybdopterin cofactor binding site; other site
1229205015822	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
1229205015823	molybdopterin cofactor binding site; other site
1229205015824	NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390
1229205015825	hypothetical protein; Provisional; Region: PRK06184
1229205015826	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1229205015827	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1229205015828	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1229205015829	dimerization interface [polypeptide binding]; other site
1229205015830	putative DNA binding site [nucleotide binding]; other site
1229205015831	putative Zn2+ binding site [ion binding]; other site
1229205015832	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1229205015833	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229205015834	TPR motif; other site
1229205015835	binding surface
1229205015836	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
1229205015837	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229205015838	binding surface
1229205015839	TPR motif; other site
1229205015840	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229205015841	binding surface
1229205015842	TPR motif; other site
1229205015843	ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782
1229205015844	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205015845	citrate-proton symporter; Provisional; Region: PRK15075
1229205015846	putative substrate translocation pore; other site
1229205015847	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1229205015848	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229205015849	Coenzyme A binding pocket [chemical binding]; other site
1229205015850	Protein of unknown function (DUF2968); Region: DUF2968; pfam11180
1229205015851	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
1229205015852	Peptidase C26; Region: Peptidase_C26; pfam07722
1229205015853	catalytic triad [active]
1229205015854	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1229205015855	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1229205015856	Protein of unknown function (DUF2848); Region: DUF2848; pfam11010
1229205015857	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205015858	D-galactonate transporter; Region: 2A0114; TIGR00893
1229205015859	putative substrate translocation pore; other site
1229205015860	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1229205015861	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205015862	DNA-binding site [nucleotide binding]; DNA binding site
1229205015863	FCD domain; Region: FCD; pfam07729
1229205015864	amidase; Provisional; Region: PRK07056
1229205015865	Amidase; Region: Amidase; cl11426
1229205015866	disulfide bond formation protein B; Provisional; Region: PRK02110
1229205015867	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
1229205015868	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1229205015869	catalytic loop [active]
1229205015870	iron binding site [ion binding]; other site
1229205015871	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1229205015872	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
1229205015873	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
1229205015874	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1229205015875	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1229205015876	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1229205015877	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
1229205015878	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1229205015879	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
1229205015880	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
1229205015881	active site
1229205015882	purine riboside binding site [chemical binding]; other site
1229205015883	guanine deaminase; Provisional; Region: PRK09228
1229205015884	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
1229205015885	active site
1229205015886	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
1229205015887	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1229205015888	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229205015889	S-adenosylmethionine binding site [chemical binding]; other site
1229205015890	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
1229205015891	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
1229205015892	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1229205015893	dimer interface [polypeptide binding]; other site
1229205015894	active site
1229205015895	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116
1229205015896	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1229205015897	dimer interface [polypeptide binding]; other site
1229205015898	active site
1229205015899	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205015900	3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831
1229205015901	NAD(P) binding site [chemical binding]; other site
1229205015902	active site
1229205015903	Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289
1229205015904	putative active site 1 [active]
1229205015905	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
1229205015906	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1229205015907	dimer interface [polypeptide binding]; other site
1229205015908	active site
1229205015909	Predicted exporter [General function prediction only]; Region: COG4258
1229205015910	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
1229205015911	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
1229205015912	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1229205015913	active site
1229205015914	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
1229205015915	active sites [active]
1229205015916	tetramer interface [polypeptide binding]; other site
1229205015917	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
1229205015918	Ligand binding site; other site
1229205015919	Putative Catalytic site; other site
1229205015920	DXD motif; other site
1229205015921	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1229205015922	putative acyl-acceptor binding pocket; other site
1229205015923	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
1229205015924	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1229205015925	AMP binding site [chemical binding]; other site
1229205015926	active site
1229205015927	acyl-activating enzyme (AAE) consensus motif; other site
1229205015928	CoA binding site [chemical binding]; other site
1229205015929	FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493
1229205015930	active site 2 [active]
1229205015931	dimer interface [polypeptide binding]; other site
1229205015932	Predicted membrane protein [Function unknown]; Region: COG4648
1229205015933	acyl carrier protein; Provisional; Region: PRK05350
1229205015934	Phosphopantetheine attachment site; Region: PP-binding; cl09936
1229205015935	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
1229205015936	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1229205015937	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1229205015938	putative acyl-acceptor binding pocket; other site
1229205015939	Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723
1229205015940	Predicted membrane protein [Function unknown]; Region: COG2119
1229205015941	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
1229205015942	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
1229205015943	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
1229205015944	aminopeptidase N; Provisional; Region: pepN; PRK14015
1229205015945	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
1229205015946	active site
1229205015947	Zn binding site [ion binding]; other site
1229205015948	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
1229205015949	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
1229205015950	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229205015951	non-specific DNA binding site [nucleotide binding]; other site
1229205015952	salt bridge; other site
1229205015953	sequence-specific DNA binding site [nucleotide binding]; other site
1229205015954	fructose-1,6-bisphosphatase family protein; Region: PLN02628
1229205015955	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
1229205015956	AMP binding site [chemical binding]; other site
1229205015957	metal binding site [ion binding]; metal-binding site
1229205015958	active site
1229205015959	chorismate mutase; Provisional; Region: PRK09269
1229205015960	Chorismate mutase type II; Region: CM_2; cl00693
1229205015961	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1229205015962	active site
1229205015963	catalytic site [active]
1229205015964	substrate binding site [chemical binding]; other site
1229205015965	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1229205015966	GIY-YIG motif/motif A; other site
1229205015967	active site
1229205015968	catalytic site [active]
1229205015969	putative DNA binding site [nucleotide binding]; other site
1229205015970	metal binding site [ion binding]; metal-binding site
1229205015971	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205015972	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205015973	trimer interface [polypeptide binding]; other site
1229205015974	eyelet of channel; other site
1229205015975	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
1229205015976	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1229205015977	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1229205015978	Protein of unknown function (DUF2591); Region: DUF2591; cl11584
1229205015979	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1229205015980	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1229205015981	Zn2+ binding site [ion binding]; other site
1229205015982	Mg2+ binding site [ion binding]; other site
1229205015983	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1229205015984	synthetase active site [active]
1229205015985	NTP binding site [chemical binding]; other site
1229205015986	metal binding site [ion binding]; metal-binding site
1229205015987	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1229205015988	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1229205015989	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1229205015990	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1229205015991	catalytic site [active]
1229205015992	G-X2-G-X-G-K; other site
1229205015993	hypothetical protein; Provisional; Region: PRK11820
1229205015994	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
1229205015995	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
1229205015996	ribonuclease PH; Reviewed; Region: rph; PRK00173
1229205015997	Ribonuclease PH; Region: RNase_PH_bact; cd11362
1229205015998	hexamer interface [polypeptide binding]; other site
1229205015999	active site
1229205016000	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1229205016001	active site
1229205016002	dimerization interface [polypeptide binding]; other site
1229205016003	coproporphyrinogen III oxidase; Provisional; Region: PRK08898
1229205016004	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1229205016005	FeS/SAM binding site; other site
1229205016006	HemN C-terminal domain; Region: HemN_C; pfam06969
1229205016007	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1229205016008	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1229205016009	inhibitor-cofactor binding pocket; inhibition site
1229205016010	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205016011	catalytic residue [active]
1229205016012	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
1229205016013	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1229205016014	catalytic motif [active]
1229205016015	Zn binding site [ion binding]; other site
1229205016016	RibD C-terminal domain; Region: RibD_C; cl17279
1229205016017	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1229205016018	Lumazine binding domain; Region: Lum_binding; pfam00677
1229205016019	Lumazine binding domain; Region: Lum_binding; pfam00677
1229205016020	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
1229205016021	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1229205016022	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
1229205016023	dimerization interface [polypeptide binding]; other site
1229205016024	active site
1229205016025	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1229205016026	homopentamer interface [polypeptide binding]; other site
1229205016027	active site
1229205016028	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
1229205016029	putative RNA binding site [nucleotide binding]; other site
1229205016030	aminotransferase; Validated; Region: PRK07337
1229205016031	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229205016032	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205016033	homodimer interface [polypeptide binding]; other site
1229205016034	catalytic residue [active]
1229205016035	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1229205016036	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1229205016037	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1229205016038	catalytic residue [active]
1229205016039	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
1229205016040	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1229205016041	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1229205016042	tetramer interface [polypeptide binding]; other site
1229205016043	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
1229205016044	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205016045	catalytic residue [active]
1229205016046	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
1229205016047	Uncharacterized conserved protein [Function unknown]; Region: COG5495
1229205016048	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
1229205016049	EthD domain; Region: EthD; cl17553
1229205016050	YGGT family; Region: YGGT; pfam02325
1229205016051	YGGT family; Region: YGGT; pfam02325
1229205016052	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1229205016053	substrate binding site [chemical binding]; other site
1229205016054	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229205016055	S-adenosylmethionine binding site [chemical binding]; other site
1229205016056	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1229205016057	Protein of unknown function (DUF1439); Region: DUF1439; cl06345
1229205016058	Flagellin N-methylase; Region: FliB; pfam03692
1229205016059	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
1229205016060	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1229205016061	FeS/SAM binding site; other site
1229205016062	HemN C-terminal domain; Region: HemN_C; pfam06969
1229205016063	aromatic amino acid transporter; Provisional; Region: PRK10238
1229205016064	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
1229205016065	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1229205016066	Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663
1229205016067	SxDxEG motif; other site
1229205016068	active site
1229205016069	metal binding site [ion binding]; metal-binding site
1229205016070	homopentamer interface [polypeptide binding]; other site
1229205016071	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
1229205016072	homodimer interface [polypeptide binding]; other site
1229205016073	homotetramer interface [polypeptide binding]; other site
1229205016074	active site pocket [active]
1229205016075	cleavage site
1229205016076	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
1229205016077	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1229205016078	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205016079	dimer interface [polypeptide binding]; other site
1229205016080	conserved gate region; other site
1229205016081	putative PBP binding loops; other site
1229205016082	ABC-ATPase subunit interface; other site
1229205016083	glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081
1229205016084	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205016085	dimer interface [polypeptide binding]; other site
1229205016086	conserved gate region; other site
1229205016087	putative PBP binding loops; other site
1229205016088	ABC-ATPase subunit interface; other site
1229205016089	glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413
1229205016090	The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499
1229205016091	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
1229205016092	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1229205016093	Walker A/P-loop; other site
1229205016094	ATP binding site [chemical binding]; other site
1229205016095	Q-loop/lid; other site
1229205016096	ABC transporter signature motif; other site
1229205016097	Walker B; other site
1229205016098	D-loop; other site
1229205016099	H-loop/switch region; other site
1229205016100	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1229205016101	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1229205016102	Walker A/P-loop; other site
1229205016103	ATP binding site [chemical binding]; other site
1229205016104	Q-loop/lid; other site
1229205016105	ABC transporter signature motif; other site
1229205016106	Walker B; other site
1229205016107	D-loop; other site
1229205016108	H-loop/switch region; other site
1229205016109	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1229205016110	Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and  L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cd04512
1229205016111	active site
1229205016112	dimer interface [polypeptide binding]; other site
1229205016113	catalytic nucleophile [active]
1229205016114	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1229205016115	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1229205016116	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1229205016117	putative active site [active]
1229205016118	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1229205016119	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
1229205016120	RNA binding surface [nucleotide binding]; other site
1229205016121	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
1229205016122	active site
1229205016123	uracil binding [chemical binding]; other site
1229205016124	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205016125	NAD(P) binding site [chemical binding]; other site
1229205016126	active site
1229205016127	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1229205016128	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
1229205016129	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1229205016130	catalytic loop [active]
1229205016131	iron binding site [ion binding]; other site
1229205016132	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
1229205016133	FAD binding pocket [chemical binding]; other site
1229205016134	FAD binding motif [chemical binding]; other site
1229205016135	phosphate binding motif [ion binding]; other site
1229205016136	beta-alpha-beta structure motif; other site
1229205016137	NAD binding pocket [chemical binding]; other site
1229205016138	acetylornithine transaminase protein; Provisional; Region: argD; PRK03715
1229205016139	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1229205016140	inhibitor-cofactor binding pocket; inhibition site
1229205016141	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205016142	catalytic residue [active]
1229205016143	putative acetyltransferase; Provisional; Region: PRK03624
1229205016144	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229205016145	Coenzyme A binding pocket [chemical binding]; other site
1229205016146	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1229205016147	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1229205016148	Walker A/P-loop; other site
1229205016149	ATP binding site [chemical binding]; other site
1229205016150	Q-loop/lid; other site
1229205016151	ABC transporter signature motif; other site
1229205016152	Walker B; other site
1229205016153	D-loop; other site
1229205016154	H-loop/switch region; other site
1229205016155	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1229205016156	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1229205016157	Walker A/P-loop; other site
1229205016158	ATP binding site [chemical binding]; other site
1229205016159	Q-loop/lid; other site
1229205016160	ABC transporter signature motif; other site
1229205016161	Walker B; other site
1229205016162	D-loop; other site
1229205016163	H-loop/switch region; other site
1229205016164	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1229205016165	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1229205016166	TM-ABC transporter signature motif; other site
1229205016167	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1229205016168	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1229205016169	TM-ABC transporter signature motif; other site
1229205016170	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1229205016171	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1229205016172	dimerization interface [polypeptide binding]; other site
1229205016173	ligand binding site [chemical binding]; other site
1229205016174	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
1229205016175	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
1229205016176	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
1229205016177	hypothetical protein; Reviewed; Region: PRK00024
1229205016178	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1229205016179	MPN+ (JAMM) motif; other site
1229205016180	Zinc-binding site [ion binding]; other site
1229205016181	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1229205016182	L-aspartate oxidase; Provisional; Region: PRK09077
1229205016183	L-aspartate oxidase; Provisional; Region: PRK06175
1229205016184	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1229205016185	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06978
1229205016186	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
1229205016187	dimerization interface [polypeptide binding]; other site
1229205016188	active site
1229205016189	quinolinate synthetase; Provisional; Region: PRK09375
1229205016190	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
1229205016191	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1229205016192	Di-iron ligands [ion binding]; other site
1229205016193	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1229205016194	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1229205016195	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1229205016196	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
1229205016197	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
1229205016198	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1229205016199	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1229205016200	active site
1229205016201	substrate binding site [chemical binding]; other site
1229205016202	cosubstrate binding site; other site
1229205016203	catalytic site [active]
1229205016204	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1229205016205	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1229205016206	active site
1229205016207	Riboflavin kinase; Region: Flavokinase; smart00904
1229205016208	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
1229205016209	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1229205016210	active site
1229205016211	HIGH motif; other site
1229205016212	nucleotide binding site [chemical binding]; other site
1229205016213	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1229205016214	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1229205016215	active site
1229205016216	KMSKS motif; other site
1229205016217	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1229205016218	tRNA binding surface [nucleotide binding]; other site
1229205016219	anticodon binding site; other site
1229205016220	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1229205016221	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
1229205016222	lipoprotein signal peptidase; Provisional; Region: PRK14787
1229205016223	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1229205016224	Flavoprotein; Region: Flavoprotein; pfam02441
1229205016225	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1229205016226	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1229205016227	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1229205016228	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1229205016229	trimer interface [polypeptide binding]; other site
1229205016230	active site
1229205016231	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
1229205016232	Clp amino terminal domain; Region: Clp_N; pfam02861
1229205016233	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205016234	Walker A motif; other site
1229205016235	ATP binding site [chemical binding]; other site
1229205016236	Walker B motif; other site
1229205016237	arginine finger; other site
1229205016238	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205016239	Walker A motif; other site
1229205016240	ATP binding site [chemical binding]; other site
1229205016241	Walker B motif; other site
1229205016242	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1229205016243	Uncharacterized conserved protein [Function unknown]; Region: COG2127
1229205016244	isocitrate dehydrogenase; Validated; Region: PRK07362
1229205016245	isocitrate dehydrogenase; Reviewed; Region: PRK07006
1229205016246	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
1229205016247	pseudouridine synthase; Region: TIGR00093
1229205016248	active site
1229205016249	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
1229205016250	elongation factor G; Reviewed; Region: PRK00007
1229205016251	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1229205016252	G1 box; other site
1229205016253	putative GEF interaction site [polypeptide binding]; other site
1229205016254	GTP/Mg2+ binding site [chemical binding]; other site
1229205016255	Switch I region; other site
1229205016256	G2 box; other site
1229205016257	G3 box; other site
1229205016258	Switch II region; other site
1229205016259	G4 box; other site
1229205016260	G5 box; other site
1229205016261	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1229205016262	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1229205016263	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1229205016264	Cupin domain; Region: Cupin_2; cl17218
1229205016265	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
1229205016266	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1229205016267	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
1229205016268	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1229205016269	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205016270	dimer interface [polypeptide binding]; other site
1229205016271	conserved gate region; other site
1229205016272	putative PBP binding loops; other site
1229205016273	ABC-ATPase subunit interface; other site
1229205016274	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1229205016275	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205016276	putative PBP binding loops; other site
1229205016277	dimer interface [polypeptide binding]; other site
1229205016278	ABC-ATPase subunit interface; other site
1229205016279	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1229205016280	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1229205016281	Walker A/P-loop; other site
1229205016282	ATP binding site [chemical binding]; other site
1229205016283	Q-loop/lid; other site
1229205016284	ABC transporter signature motif; other site
1229205016285	Walker B; other site
1229205016286	D-loop; other site
1229205016287	H-loop/switch region; other site
1229205016288	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1229205016289	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
1229205016290	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1229205016291	Walker A/P-loop; other site
1229205016292	ATP binding site [chemical binding]; other site
1229205016293	Q-loop/lid; other site
1229205016294	ABC transporter signature motif; other site
1229205016295	Walker B; other site
1229205016296	D-loop; other site
1229205016297	H-loop/switch region; other site
1229205016298	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1229205016299	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1229205016300	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1229205016301	active site
1229205016302	catalytic tetrad [active]
1229205016303	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1229205016304	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205016305	DNA-binding site [nucleotide binding]; DNA binding site
1229205016306	UTRA domain; Region: UTRA; pfam07702
1229205016307	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1229205016308	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1229205016309	Helix-turn-helix domain; Region: HTH_17; pfam12728
1229205016310	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1229205016311	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
1229205016312	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102
1229205016313	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1229205016314	dimer interface [polypeptide binding]; other site
1229205016315	active site
1229205016316	oxalacetate/citrate binding site [chemical binding]; other site
1229205016317	citrylCoA binding site [chemical binding]; other site
1229205016318	coenzyme A binding site [chemical binding]; other site
1229205016319	catalytic triad [active]
1229205016320	Protein of unknown function (DUF2917); Region: DUF2917; pfam11142
1229205016321	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1229205016322	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205016323	DNA-binding site [nucleotide binding]; DNA binding site
1229205016324	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229205016325	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205016326	homodimer interface [polypeptide binding]; other site
1229205016327	catalytic residue [active]
1229205016328	putative transporter; Provisional; Region: PRK10504
1229205016329	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205016330	putative substrate translocation pore; other site
1229205016331	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
1229205016332	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1229205016333	DNA binding residues [nucleotide binding]
1229205016334	Clp protease; Region: CLP_protease; pfam00574
1229205016335	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1229205016336	oligomer interface [polypeptide binding]; other site
1229205016337	active site residues [active]
1229205016338	LabA_like proteins; Region: LabA_like; cd06167
1229205016339	putative metal binding site [ion binding]; other site
1229205016340	Uncharacterized conserved protein [Function unknown]; Region: COG1432
1229205016341	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
1229205016342	Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436
1229205016343	superoxide dismutase; Provisional; Region: PRK10543
1229205016344	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1229205016345	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1229205016346	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1229205016347	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1229205016348	generic binding surface II; other site
1229205016349	generic binding surface I; other site
1229205016350	tetraacyldisaccharide 4'-kinase; Provisional; Region: PRK01906
1229205016351	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
1229205016352	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
1229205016353	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
1229205016354	Ligand binding site; other site
1229205016355	oligomer interface; other site
1229205016356	adenylate kinase; Reviewed; Region: adk; PRK00279
1229205016357	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1229205016358	AMP-binding site [chemical binding]; other site
1229205016359	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1229205016360	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
1229205016361	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
1229205016362	NAD binding site [chemical binding]; other site
1229205016363	homodimer interface [polypeptide binding]; other site
1229205016364	homotetramer interface [polypeptide binding]; other site
1229205016365	active site
1229205016366	Uncharacterized conserved protein [Function unknown]; Region: COG2912
1229205016367	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
1229205016368	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
1229205016369	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
1229205016370	Protein of unknown function (DUF3579); Region: DUF3579; pfam12112
1229205016371	ornithine carbamoyltransferase; Provisional; Region: PRK00779
1229205016372	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1229205016373	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1229205016374	argininosuccinate synthase; Provisional; Region: PRK13820
1229205016375	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1229205016376	ANP binding site [chemical binding]; other site
1229205016377	Substrate Binding Site II [chemical binding]; other site
1229205016378	Substrate Binding Site I [chemical binding]; other site
1229205016379	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
1229205016380	FAD binding domain; Region: FAD_binding_4; pfam01565
1229205016381	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1229205016382	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
1229205016383	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
1229205016384	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
1229205016385	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
1229205016386	putative deacylase active site [active]
1229205016387	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
1229205016388	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1229205016389	acyl-activating enzyme (AAE) consensus motif; other site
1229205016390	AMP binding site [chemical binding]; other site
1229205016391	active site
1229205016392	CoA binding site [chemical binding]; other site
1229205016393	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
1229205016394	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1229205016395	active site
1229205016396	Int/Topo IB signature motif; other site
1229205016397	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1229205016398	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1229205016399	DNA binding site [nucleotide binding]
1229205016400	active site
1229205016401	epoxyqueuosine reductase; Region: TIGR00276
1229205016402	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
1229205016403	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
1229205016404	AMIN domain; Region: AMIN; pfam11741
1229205016405	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1229205016406	active site
1229205016407	metal binding site [ion binding]; metal-binding site
1229205016408	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
1229205016409	Pirin-related protein [General function prediction only]; Region: COG1741
1229205016410	Pirin; Region: Pirin; pfam02678
1229205016411	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
1229205016412	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
1229205016413	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1229205016414	catalytic residues [active]
1229205016415	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
1229205016416	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
1229205016417	putative ATP binding site [chemical binding]; other site
1229205016418	putative substrate interface [chemical binding]; other site
1229205016419	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
1229205016420	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1229205016421	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
1229205016422	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
1229205016423	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229205016424	S-adenosylmethionine binding site [chemical binding]; other site
1229205016425	Protein of unknown function DUF72; Region: DUF72; pfam01904
1229205016426	methionine sulfoxide reductase A; Provisional; Region: PRK14054
1229205016427	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1229205016428	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1229205016429	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1229205016430	putative DNA binding site [nucleotide binding]; other site
1229205016431	putative Zn2+ binding site [ion binding]; other site
1229205016432	AsnC family; Region: AsnC_trans_reg; pfam01037
1229205016433	arylformamidase; Region: trp_arylform; TIGR03035
1229205016434	Kynureninase [Amino acid transport and metabolism]; Region: COG3844
1229205016435	kynureninase; Region: kynureninase; TIGR01814
1229205016436	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1229205016437	catalytic residue [active]
1229205016438	tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036
1229205016439	short chain dehydrogenase; Provisional; Region: PRK07060
1229205016440	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205016441	NAD(P) binding site [chemical binding]; other site
1229205016442	active site
1229205016443	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
1229205016444	uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804
1229205016445	N- and C-terminal domain interface [polypeptide binding]; other site
1229205016446	putative active site [active]
1229205016447	MgATP binding site [chemical binding]; other site
1229205016448	catalytic site [active]
1229205016449	metal binding site [ion binding]; metal-binding site
1229205016450	putative xylulose binding site [chemical binding]; other site
1229205016451	putative homodimer interface [polypeptide binding]; other site
1229205016452	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1229205016453	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH2; cd08256
1229205016454	putative NAD(P) binding site [chemical binding]; other site
1229205016455	catalytic Zn binding site [ion binding]; other site
1229205016456	structural Zn binding site [ion binding]; other site
1229205016457	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1229205016458	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1229205016459	TM-ABC transporter signature motif; other site
1229205016460	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1229205016461	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1229205016462	Walker A/P-loop; other site
1229205016463	ATP binding site [chemical binding]; other site
1229205016464	Q-loop/lid; other site
1229205016465	ABC transporter signature motif; other site
1229205016466	Walker B; other site
1229205016467	D-loop; other site
1229205016468	H-loop/switch region; other site
1229205016469	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1229205016470	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321
1229205016471	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1229205016472	putative ligand binding site [chemical binding]; other site
1229205016473	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1229205016474	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1229205016475	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205016476	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
1229205016477	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1229205016478	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1229205016479	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
1229205016480	N- and C-terminal domain interface [polypeptide binding]; other site
1229205016481	D-xylulose kinase; Region: XylB; TIGR01312
1229205016482	active site
1229205016483	MgATP binding site [chemical binding]; other site
1229205016484	catalytic site [active]
1229205016485	metal binding site [ion binding]; metal-binding site
1229205016486	xylulose binding site [chemical binding]; other site
1229205016487	homodimer interface [polypeptide binding]; other site
1229205016488	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1229205016489	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1229205016490	maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000
1229205016491	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1229205016492	Walker A/P-loop; other site
1229205016493	ATP binding site [chemical binding]; other site
1229205016494	Q-loop/lid; other site
1229205016495	ABC transporter signature motif; other site
1229205016496	Walker B; other site
1229205016497	D-loop; other site
1229205016498	H-loop/switch region; other site
1229205016499	TOBE domain; Region: TOBE_2; pfam08402
1229205016500	TOBE domain; Region: TOBE_2; pfam08402
1229205016501	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1229205016502	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229205016503	active site
1229205016504	motif I; other site
1229205016505	motif II; other site
1229205016506	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1229205016507	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205016508	dimer interface [polypeptide binding]; other site
1229205016509	conserved gate region; other site
1229205016510	putative PBP binding loops; other site
1229205016511	ABC-ATPase subunit interface; other site
1229205016512	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205016513	ABC-ATPase subunit interface; other site
1229205016514	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1229205016515	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1229205016516	sorbitol dehydrogenase; Provisional; Region: PRK07067
1229205016517	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205016518	NAD(P) binding site [chemical binding]; other site
1229205016519	active site
1229205016520	Metal binding protein TroA_b.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020
1229205016521	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1229205016522	metal binding site [ion binding]; metal-binding site
1229205016523	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1229205016524	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1229205016525	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1229205016526	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
1229205016527	ABC-ATPase subunit  interface; other site
1229205016528	dimer interface [polypeptide binding]; other site
1229205016529	putative PBP binding regions; other site
1229205016530	S-formylglutathione hydrolase; Region: PLN02442
1229205016531	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
1229205016532	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
1229205016533	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
1229205016534	substrate binding site [chemical binding]; other site
1229205016535	catalytic Zn binding site [ion binding]; other site
1229205016536	NAD binding site [chemical binding]; other site
1229205016537	structural Zn binding site [ion binding]; other site
1229205016538	dimer interface [polypeptide binding]; other site
1229205016539	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1229205016540	D-xylulose kinase; Region: XylB; TIGR01312
1229205016541	nucleotide binding site [chemical binding]; other site
1229205016542	xanthine permease; Region: pbuX; TIGR03173
1229205016543	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1229205016544	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
1229205016545	Protein export membrane protein; Region: SecD_SecF; cl14618
1229205016546	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1229205016547	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1229205016548	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1229205016549	HlyD family secretion protein; Region: HlyD_3; pfam13437
1229205016550	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
1229205016551	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229205016552	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
1229205016553	Isochorismatase family; Region: Isochorismatase; pfam00857
1229205016554	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
1229205016555	catalytic triad [active]
1229205016556	conserved cis-peptide bond; other site
1229205016557	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
1229205016558	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1229205016559	conserved cys residue [active]
1229205016560	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205016561	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
1229205016562	putative hydrophobic ligand binding site [chemical binding]; other site
1229205016563	Domain of unknown function (DUF427); Region: DUF427; pfam04248
1229205016564	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
1229205016565	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
1229205016566	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1229205016567	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1229205016568	protein binding site [polypeptide binding]; other site
1229205016569	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1229205016570	protein binding site [polypeptide binding]; other site
1229205016571	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229205016572	HAMP domain; Region: HAMP; pfam00672
1229205016573	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205016574	dimer interface [polypeptide binding]; other site
1229205016575	phosphorylation site [posttranslational modification]
1229205016576	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205016577	ATP binding site [chemical binding]; other site
1229205016578	Mg2+ binding site [ion binding]; other site
1229205016579	G-X-G motif; other site
1229205016580	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
1229205016581	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205016582	active site
1229205016583	phosphorylation site [posttranslational modification]
1229205016584	intermolecular recognition site; other site
1229205016585	dimerization interface [polypeptide binding]; other site
1229205016586	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229205016587	DNA binding site [nucleotide binding]
1229205016588	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
1229205016589	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
1229205016590	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
1229205016591	Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847
1229205016592	active site
1229205016593	catalytic triad [active]
1229205016594	oxyanion hole [active]
1229205016595	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1229205016596	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
1229205016597	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1229205016598	ATP-grasp domain; Region: ATP-grasp; pfam02222
1229205016599	AIR carboxylase; Region: AIRC; pfam00731
1229205016600	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
1229205016601	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
1229205016602	ATP binding site [chemical binding]; other site
1229205016603	active site
1229205016604	substrate binding site [chemical binding]; other site
1229205016605	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1229205016606	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1229205016607	intersubunit interface [polypeptide binding]; other site
1229205016608	active site
1229205016609	zinc binding site [ion binding]; other site
1229205016610	Na+ binding site [ion binding]; other site
1229205016611	pyruvate kinase; Provisional; Region: PRK05826
1229205016612	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1229205016613	domain interfaces; other site
1229205016614	active site
1229205016615	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
1229205016616	Phosphoglycerate kinase; Region: PGK; pfam00162
1229205016617	substrate binding site [chemical binding]; other site
1229205016618	hinge regions; other site
1229205016619	ADP binding site [chemical binding]; other site
1229205016620	catalytic site [active]
1229205016621	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
1229205016622	AzlC protein; Region: AzlC; cl00570
1229205016623	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1229205016624	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1229205016625	homodimer interface [polypeptide binding]; other site
1229205016626	substrate-cofactor binding pocket; other site
1229205016627	catalytic residue [active]
1229205016628	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1229205016629	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1229205016630	putative active site [active]
1229205016631	SnoaL-like domain; Region: SnoaL_3; pfam13474
1229205016632	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
1229205016633	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
1229205016634	Protein of unknown function (DUF2946); Region: DUF2944; pfam11161
1229205016635	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
1229205016636	Peptidase family M48; Region: Peptidase_M48; pfam01435
1229205016637	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1229205016638	trimer interface [polypeptide binding]; other site
1229205016639	dimer interface [polypeptide binding]; other site
1229205016640	putative active site [active]
1229205016641	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
1229205016642	O-Antigen ligase; Region: Wzy_C; pfam04932
1229205016643	Domain of unknown function (DUF3366); Region: DUF3366; pfam11846
1229205016644	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
1229205016645	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
1229205016646	Pilin (bacterial filament); Region: Pilin; pfam00114
1229205016647	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
1229205016648	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
1229205016649	CoA binding domain; Region: CoA_binding; smart00881
1229205016650	CoA-ligase; Region: Ligase_CoA; pfam00549
1229205016651	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
1229205016652	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1229205016653	CoA-ligase; Region: Ligase_CoA; pfam00549
1229205016654	Protein of unknown function (DUF2889); Region: DUF2889; pfam11136
1229205016655	RecX family; Region: RecX; cl00936
1229205016656	recombinase A; Provisional; Region: recA; PRK09354
1229205016657	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1229205016658	hexamer interface [polypeptide binding]; other site
1229205016659	Walker A motif; other site
1229205016660	ATP binding site [chemical binding]; other site
1229205016661	Walker B motif; other site
1229205016662	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1229205016663	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205016664	active site
1229205016665	phosphorylation site [posttranslational modification]
1229205016666	intermolecular recognition site; other site
1229205016667	dimerization interface [polypeptide binding]; other site
1229205016668	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229205016669	DNA binding site [nucleotide binding]
1229205016670	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
1229205016671	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229205016672	HAMP domain; Region: HAMP; pfam00672
1229205016673	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205016674	dimer interface [polypeptide binding]; other site
1229205016675	phosphorylation site [posttranslational modification]
1229205016676	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205016677	ATP binding site [chemical binding]; other site
1229205016678	Mg2+ binding site [ion binding]; other site
1229205016679	G-X-G motif; other site
1229205016680	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205016681	putative substrate translocation pore; other site
1229205016682	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1229205016683	MarR family; Region: MarR; pfam01047
1229205016684	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1229205016685	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205016686	putative substrate translocation pore; other site
1229205016687	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205016688	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1229205016689	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205016690	DNA-binding site [nucleotide binding]; DNA binding site
1229205016691	FCD domain; Region: FCD; pfam07729
1229205016692	galactonate dehydratase; Provisional; Region: PRK14017
1229205016693	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
1229205016694	putative active site pocket [active]
1229205016695	putative metal binding site [ion binding]; other site
1229205016696	CopC domain; Region: CopC; pfam04234
1229205016697	Cytochrome c553 [Energy production and conversion]; Region: COG2863
1229205016698	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1229205016699	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1229205016700	Cytochrome c; Region: Cytochrom_C; cl11414
1229205016701	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1229205016702	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1229205016703	Cytochrome c; Region: Cytochrom_C; pfam00034
1229205016704	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1229205016705	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
1229205016706	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1229205016707	ATP binding site [chemical binding]; other site
1229205016708	Mg++ binding site [ion binding]; other site
1229205016709	motif III; other site
1229205016710	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1229205016711	nucleotide binding region [chemical binding]; other site
1229205016712	ATP-binding site [chemical binding]; other site
1229205016713	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
1229205016714	dinuclear metal binding motif [ion binding]; other site
1229205016715	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1229205016716	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1229205016717	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1229205016718	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1229205016719	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1229205016720	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
1229205016721	glycerol kinase; Provisional; Region: glpK; PRK00047
1229205016722	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1229205016723	N- and C-terminal domain interface [polypeptide binding]; other site
1229205016724	active site
1229205016725	MgATP binding site [chemical binding]; other site
1229205016726	catalytic site [active]
1229205016727	metal binding site [ion binding]; metal-binding site
1229205016728	glycerol binding site [chemical binding]; other site
1229205016729	homotetramer interface [polypeptide binding]; other site
1229205016730	homodimer interface [polypeptide binding]; other site
1229205016731	FBP binding site [chemical binding]; other site
1229205016732	protein IIAGlc interface [polypeptide binding]; other site
1229205016733	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
1229205016734	amphipathic channel; other site
1229205016735	Asn-Pro-Ala signature motifs; other site
1229205016736	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1229205016737	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229205016738	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
1229205016739	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
1229205016740	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1229205016741	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229205016742	non-specific DNA binding site [nucleotide binding]; other site
1229205016743	salt bridge; other site
1229205016744	sequence-specific DNA binding site [nucleotide binding]; other site
1229205016745	Cupin domain; Region: Cupin_2; pfam07883
1229205016746	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1229205016747	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205016748	putative substrate translocation pore; other site
1229205016749	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1229205016750	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
1229205016751	dimer interface [polypeptide binding]; other site
1229205016752	putative metal binding site [ion binding]; other site
1229205016753	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205016754	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205016755	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1229205016756	putative effector binding pocket; other site
1229205016757	dimerization interface [polypeptide binding]; other site
1229205016758	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
1229205016759	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1229205016760	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1229205016761	FeS/SAM binding site; other site
1229205016762	TRAM domain; Region: TRAM; pfam01938
1229205016763	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1229205016764	PhoH-like protein; Region: PhoH; pfam02562
1229205016765	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
1229205016766	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1229205016767	putative active site pocket [active]
1229205016768	dimerization interface [polypeptide binding]; other site
1229205016769	putative catalytic residue [active]
1229205016770	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
1229205016771	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1229205016772	Transporter associated domain; Region: CorC_HlyC; smart01091
1229205016773	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
1229205016774	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
1229205016775	putative active site [active]
1229205016776	catalytic triad [active]
1229205016777	putative dimer interface [polypeptide binding]; other site
1229205016778	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
1229205016779	putative glutathione S-transferase; Provisional; Region: PRK10357
1229205016780	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
1229205016781	putative C-terminal domain interface [polypeptide binding]; other site
1229205016782	putative GSH binding site (G-site) [chemical binding]; other site
1229205016783	putative dimer interface [polypeptide binding]; other site
1229205016784	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
1229205016785	dimer interface [polypeptide binding]; other site
1229205016786	N-terminal domain interface [polypeptide binding]; other site
1229205016787	putative substrate binding pocket (H-site) [chemical binding]; other site
1229205016788	proline aminopeptidase P II; Provisional; Region: PRK10879
1229205016789	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
1229205016790	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
1229205016791	active site
1229205016792	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1229205016793	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1229205016794	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
1229205016795	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1229205016796	FMN binding site [chemical binding]; other site
1229205016797	active site
1229205016798	catalytic residues [active]
1229205016799	substrate binding site [chemical binding]; other site
1229205016800	DNA-binding protein Fis; Provisional; Region: PRK01905
1229205016801	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1229205016802	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1229205016803	purine monophosphate binding site [chemical binding]; other site
1229205016804	dimer interface [polypeptide binding]; other site
1229205016805	putative catalytic residues [active]
1229205016806	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1229205016807	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1229205016808	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
1229205016809	active site
1229205016810	putative DNA-binding cleft [nucleotide binding]; other site
1229205016811	dimer interface [polypeptide binding]; other site
1229205016812	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1229205016813	RuvA N terminal domain; Region: RuvA_N; pfam01330
1229205016814	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1229205016815	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1229205016816	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205016817	Walker A motif; other site
1229205016818	ATP binding site [chemical binding]; other site
1229205016819	Walker B motif; other site
1229205016820	arginine finger; other site
1229205016821	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1229205016822	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
1229205016823	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1229205016824	catalytic core [active]
1229205016825	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1229205016826	putative active site [active]
1229205016827	dimerization interface [polypeptide binding]; other site
1229205016828	putative tRNAtyr binding site [nucleotide binding]; other site
1229205016829	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1229205016830	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1229205016831	active site
1229205016832	HIGH motif; other site
1229205016833	dimer interface [polypeptide binding]; other site
1229205016834	KMSKS motif; other site
1229205016835	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1229205016836	RNA binding surface [nucleotide binding]; other site
1229205016837	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
1229205016838	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
1229205016839	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1229205016840	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1229205016841	23S rRNA interface [nucleotide binding]; other site
1229205016842	L3 interface [polypeptide binding]; other site
1229205016843	OsmC-like protein; Region: OsmC; cl00767
1229205016844	Protein of unknown function (DUF3025); Region: DUF3025; pfam11227
1229205016845	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
1229205016846	active site
1229205016847	substrate binding pocket [chemical binding]; other site
1229205016848	dimer interface [polypeptide binding]; other site
1229205016849	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
1229205016850	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
1229205016851	putative dimer interface [polypeptide binding]; other site
1229205016852	putative active site [active]
1229205016853	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1229205016854	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1229205016855	Walker A/P-loop; other site
1229205016856	ATP binding site [chemical binding]; other site
1229205016857	Q-loop/lid; other site
1229205016858	ABC transporter signature motif; other site
1229205016859	Walker B; other site
1229205016860	D-loop; other site
1229205016861	H-loop/switch region; other site
1229205016862	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1229205016863	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205016864	dimer interface [polypeptide binding]; other site
1229205016865	conserved gate region; other site
1229205016866	putative PBP binding loops; other site
1229205016867	ABC-ATPase subunit interface; other site
1229205016868	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1229205016869	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205016870	dimer interface [polypeptide binding]; other site
1229205016871	conserved gate region; other site
1229205016872	putative PBP binding loops; other site
1229205016873	ABC-ATPase subunit interface; other site
1229205016874	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
1229205016875	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229205016876	substrate binding pocket [chemical binding]; other site
1229205016877	membrane-bound complex binding site; other site
1229205016878	hinge residues; other site
1229205016879	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1229205016880	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1229205016881	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
1229205016882	NAD(P) binding site [chemical binding]; other site
1229205016883	cell density-dependent motility repressor; Provisional; Region: PRK10082
1229205016884	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205016885	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1229205016886	dimerization interface [polypeptide binding]; other site
1229205016887	adenylosuccinate lyase; Provisional; Region: PRK09285
1229205016888	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
1229205016889	tetramer interface [polypeptide binding]; other site
1229205016890	active site
1229205016891	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
1229205016892	ATP-binding site [chemical binding]; other site
1229205016893	Gluconate-6-phosphate binding site [chemical binding]; other site
1229205016894	Shikimate kinase; Region: SKI; pfam01202
1229205016895	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1229205016896	GntP family permease; Region: GntP_permease; pfam02447
1229205016897	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
1229205016898	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1229205016899	active site
1229205016900	intersubunit interface [polypeptide binding]; other site
1229205016901	catalytic residue [active]
1229205016902	phosphogluconate dehydratase; Validated; Region: PRK09054
1229205016903	6-phosphogluconate dehydratase; Region: edd; TIGR01196
1229205016904	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1229205016905	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1229205016906	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1229205016907	putative active site [active]
1229205016908	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1229205016909	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229205016910	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1229205016911	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1229205016912	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
1229205016913	Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
1229205016914	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1229205016915	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1229205016916	putative catalytic cysteine [active]
1229205016917	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
1229205016918	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1229205016919	Lipopolysaccharide-assembly; Region: LptE; cl01125
1229205016920	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1229205016921	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1229205016922	HIGH motif; other site
1229205016923	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1229205016924	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1229205016925	active site
1229205016926	KMSKS motif; other site
1229205016927	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1229205016928	tRNA binding surface [nucleotide binding]; other site
1229205016929	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1229205016930	TolR protein; Region: tolR; TIGR02801
1229205016931	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
1229205016932	dihydrodipicolinate reductase; Provisional; Region: PRK00048
1229205016933	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1229205016934	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1229205016935	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
1229205016936	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
1229205016937	ferric uptake regulator; Provisional; Region: fur; PRK09462
1229205016938	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1229205016939	metal binding site 2 [ion binding]; metal-binding site
1229205016940	putative DNA binding helix; other site
1229205016941	metal binding site 1 [ion binding]; metal-binding site
1229205016942	dimer interface [polypeptide binding]; other site
1229205016943	structural Zn2+ binding site [ion binding]; other site
1229205016944	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
1229205016945	ureidoglycolate hydrolase; Provisional; Region: PRK03606
1229205016946	allantoicase; Provisional; Region: PRK13257
1229205016947	Allantoicase repeat; Region: Allantoicase; pfam03561
1229205016948	Allantoicase repeat; Region: Allantoicase; pfam03561
1229205016949	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027
1229205016950	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1229205016951	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1229205016952	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205016953	DNA-binding site [nucleotide binding]; DNA binding site
1229205016954	FCD domain; Region: FCD; pfam07729
1229205016955	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
1229205016956	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1229205016957	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1229205016958	transketolase; Reviewed; Region: PRK12753
1229205016959	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1229205016960	TPP-binding site [chemical binding]; other site
1229205016961	dimer interface [polypeptide binding]; other site
1229205016962	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1229205016963	PYR/PP interface [polypeptide binding]; other site
1229205016964	dimer interface [polypeptide binding]; other site
1229205016965	TPP binding site [chemical binding]; other site
1229205016966	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1229205016967	spermidine synthase; Provisional; Region: PRK00811
1229205016968	Spermidine synthase [Amino acid transport and metabolism]; Region: SpeE; COG0421
1229205016969	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
1229205016970	putative dimer interface [polypeptide binding]; other site
1229205016971	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
1229205016972	Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141
1229205016973	putative RNAase interaction site [polypeptide binding]; other site
1229205016974	RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607
1229205016975	active site
1229205016976	barstar interaction site; other site
1229205016977	malic enzyme; Reviewed; Region: PRK12862
1229205016978	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1229205016979	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1229205016980	putative NAD(P) binding site [chemical binding]; other site
1229205016981	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
1229205016982	thiamine monophosphate kinase; Provisional; Region: PRK05731
1229205016983	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
1229205016984	ATP binding site [chemical binding]; other site
1229205016985	dimerization interface [polypeptide binding]; other site
1229205016986	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
1229205016987	tetramer interfaces [polypeptide binding]; other site
1229205016988	binuclear metal-binding site [ion binding]; other site
1229205016989	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
1229205016990	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
1229205016991	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1229205016992	active site
1229205016993	dimer interface [polypeptide binding]; other site
1229205016994	aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021
1229205016995	active site
1229205016996	catalytic residues [active]
1229205016997	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1229205016998	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1229205016999	classical (c) SDRs; Region: SDR_c; cd05233
1229205017000	NAD(P) binding site [chemical binding]; other site
1229205017001	active site
1229205017002	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1229205017003	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1229205017004	TM-ABC transporter signature motif; other site
1229205017005	L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288
1229205017006	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1229205017007	Walker A/P-loop; other site
1229205017008	ATP binding site [chemical binding]; other site
1229205017009	Q-loop/lid; other site
1229205017010	ABC transporter signature motif; other site
1229205017011	Walker B; other site
1229205017012	D-loop; other site
1229205017013	H-loop/switch region; other site
1229205017014	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1229205017015	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1229205017016	Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540
1229205017017	ligand binding site [chemical binding]; other site
1229205017018	short chain dehydrogenase; Provisional; Region: PRK07063
1229205017019	classical (c) SDRs; Region: SDR_c; cd05233
1229205017020	NAD(P) binding site [chemical binding]; other site
1229205017021	active site
1229205017022	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
1229205017023	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1229205017024	active site
1229205017025	intersubunit interface [polypeptide binding]; other site
1229205017026	catalytic residue [active]
1229205017027	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
1229205017028	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
1229205017029	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1229205017030	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1229205017031	Bacterial transcriptional regulator; Region: IclR; pfam01614
1229205017032	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
1229205017033	Transglycosylase; Region: Transgly; cl17702
1229205017034	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
1229205017035	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1229205017036	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1229205017037	shikimate binding site; other site
1229205017038	NAD(P) binding site [chemical binding]; other site
1229205017039	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
1229205017040	RNB domain; Region: RNB; pfam00773
1229205017041	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
1229205017042	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1229205017043	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
1229205017044	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1229205017045	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1229205017046	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1229205017047	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1229205017048	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1229205017049	catalytic residues [active]
1229205017050	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1229205017051	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1229205017052	active site
1229205017053	trimer interface [polypeptide binding]; other site
1229205017054	dimer interface [polypeptide binding]; other site
1229205017055	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1229205017056	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1229205017057	carboxyltransferase (CT) interaction site; other site
1229205017058	biotinylation site [posttranslational modification]; other site
1229205017059	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1229205017060	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1229205017061	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1229205017062	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1229205017063	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
1229205017064	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229205017065	S-adenosylmethionine binding site [chemical binding]; other site
1229205017066	MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098
1229205017067	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
1229205017068	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1229205017069	dimer interface [polypeptide binding]; other site
1229205017070	catalytic triad [active]
1229205017071	peroxidatic and resolving cysteines [active]
1229205017072	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
1229205017073	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1229205017074	substrate binding site [chemical binding]; other site
1229205017075	ATP binding site [chemical binding]; other site
1229205017076	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
1229205017077	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1229205017078	dimer interface [polypeptide binding]; other site
1229205017079	putative radical transfer pathway; other site
1229205017080	diiron center [ion binding]; other site
1229205017081	tyrosyl radical; other site
1229205017082	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
1229205017083	ATP cone domain; Region: ATP-cone; pfam03477
1229205017084	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1229205017085	active site
1229205017086	dimer interface [polypeptide binding]; other site
1229205017087	catalytic residues [active]
1229205017088	effector binding site; other site
1229205017089	R2 peptide binding site; other site
1229205017090	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
1229205017091	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1229205017092	amidase catalytic site [active]
1229205017093	Zn binding residues [ion binding]; other site
1229205017094	substrate binding site [chemical binding]; other site
1229205017095	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
1229205017096	signal recognition particle protein; Provisional; Region: PRK10867
1229205017097	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1229205017098	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1229205017099	P loop; other site
1229205017100	GTP binding site [chemical binding]; other site
1229205017101	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1229205017102	Methyl-coenzyme M reductase operon protein C; Region: MCR_C; cl01674
1229205017103	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1229205017104	active site
1229205017105	MarC family integral membrane protein; Region: MarC; cl00919
1229205017106	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1229205017107	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1229205017108	dimer interface [polypeptide binding]; other site
1229205017109	motif 1; other site
1229205017110	active site
1229205017111	motif 2; other site
1229205017112	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1229205017113	putative deacylase active site [active]
1229205017114	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1229205017115	active site
1229205017116	motif 3; other site
1229205017117	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1229205017118	anticodon binding site; other site
1229205017119	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
1229205017120	putative active site [active]
1229205017121	Ap4A binding site [chemical binding]; other site
1229205017122	nudix motif; other site
1229205017123	putative metal binding site [ion binding]; other site
1229205017124	CNP1-like family; Region: CNP1; pfam08750
1229205017125	gamma-glutamyl kinase; Provisional; Region: PRK05429
1229205017126	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1229205017127	nucleotide binding site [chemical binding]; other site
1229205017128	homotetrameric interface [polypeptide binding]; other site
1229205017129	putative phosphate binding site [ion binding]; other site
1229205017130	putative allosteric binding site; other site
1229205017131	PUA domain; Region: PUA; pfam01472
1229205017132	GTPase CgtA; Reviewed; Region: obgE; PRK12299
1229205017133	GTP1/OBG; Region: GTP1_OBG; pfam01018
1229205017134	Obg GTPase; Region: Obg; cd01898
1229205017135	G1 box; other site
1229205017136	GTP/Mg2+ binding site [chemical binding]; other site
1229205017137	Switch I region; other site
1229205017138	G2 box; other site
1229205017139	G3 box; other site
1229205017140	Switch II region; other site
1229205017141	G4 box; other site
1229205017142	G5 box; other site
1229205017143	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1229205017144	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
1229205017145	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1229205017146	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1229205017147	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1229205017148	substrate binding pocket [chemical binding]; other site
1229205017149	chain length determination region; other site
1229205017150	substrate-Mg2+ binding site; other site
1229205017151	catalytic residues [active]
1229205017152	aspartate-rich region 1; other site
1229205017153	active site lid residues [active]
1229205017154	aspartate-rich region 2; other site
1229205017155	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
1229205017156	Domain of unknown function DUF21; Region: DUF21; pfam01595
1229205017157	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1229205017158	Transporter associated domain; Region: CorC_HlyC; smart01091
1229205017159	Type II/IV secretion system protein; Region: T2SE; pfam00437
1229205017160	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1229205017161	Walker A motif; other site
1229205017162	ATP binding site [chemical binding]; other site
1229205017163	Walker B motif; other site
1229205017164	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
1229205017165	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1229205017166	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
1229205017167	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
1229205017168	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
1229205017169	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1229205017170	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1229205017171	CoA-binding site [chemical binding]; other site
1229205017172	ATP-binding [chemical binding]; other site
1229205017173	hypothetical protein; Provisional; Region: PRK05287
1229205017174	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
1229205017175	active site
1229205017176	8-oxo-dGMP binding site [chemical binding]; other site
1229205017177	nudix motif; other site
1229205017178	metal binding site [ion binding]; metal-binding site
1229205017179	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
1229205017180	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205017181	Walker A motif; other site
1229205017182	ATP binding site [chemical binding]; other site
1229205017183	Walker B motif; other site
1229205017184	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1229205017185	heterotetramer interface [polypeptide binding]; other site
1229205017186	active site pocket [active]
1229205017187	cleavage site
1229205017188	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1229205017189	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1229205017190	SEC-C motif; Region: SEC-C; pfam02810
1229205017191	Protein of unknown function (DUF721); Region: DUF721; cl02324
1229205017192	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
1229205017193	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
1229205017194	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
1229205017195	catalytic triad [active]
1229205017196	dimer interface [polypeptide binding]; other site
1229205017197	cell division protein FtsZ; Validated; Region: PRK09330
1229205017198	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1229205017199	nucleotide binding site [chemical binding]; other site
1229205017200	SulA interaction site; other site
1229205017201	cell division protein FtsA; Region: ftsA; TIGR01174
1229205017202	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1229205017203	nucleotide binding site [chemical binding]; other site
1229205017204	Cell division protein FtsA; Region: FtsA; pfam14450
1229205017205	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
1229205017206	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1229205017207	Cell division protein FtsQ; Region: FtsQ; pfam03799
1229205017208	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
1229205017209	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1229205017210	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
1229205017211	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1229205017212	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1229205017213	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1229205017214	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1229205017215	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1229205017216	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1229205017217	active site
1229205017218	homodimer interface [polypeptide binding]; other site
1229205017219	cell division protein FtsW; Region: ftsW; TIGR02614
1229205017220	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006
1229205017221	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1229205017222	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1229205017223	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1229205017224	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1229205017225	Mg++ binding site [ion binding]; other site
1229205017226	putative catalytic motif [active]
1229205017227	putative substrate binding site [chemical binding]; other site
1229205017228	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1229205017229	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
1229205017230	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1229205017231	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1229205017232	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1229205017233	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1229205017234	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1229205017235	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1229205017236	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1229205017237	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1229205017238	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1229205017239	Cell division protein FtsL; Region: FtsL; cl11433
1229205017240	MraW methylase family; Region: Methyltransf_5; cl17771
1229205017241	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
1229205017242	cell division protein MraZ; Reviewed; Region: PRK00326
1229205017243	MraZ protein; Region: MraZ; pfam02381
1229205017244	MraZ protein; Region: MraZ; pfam02381
1229205017245	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
1229205017246	diiron binding motif [ion binding]; other site
1229205017247	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205017248	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205017249	trimer interface [polypeptide binding]; other site
1229205017250	eyelet of channel; other site
1229205017251	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
1229205017252	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1229205017253	acyl-activating enzyme (AAE) consensus motif; other site
1229205017254	putative AMP binding site [chemical binding]; other site
1229205017255	putative active site [active]
1229205017256	putative CoA binding site [chemical binding]; other site
1229205017257	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
1229205017258	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
1229205017259	putative molybdopterin cofactor binding site [chemical binding]; other site
1229205017260	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
1229205017261	putative molybdopterin cofactor binding site; other site
1229205017262	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1229205017263	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
1229205017264	metal binding site [ion binding]; metal-binding site
1229205017265	putative dimer interface [polypeptide binding]; other site
1229205017266	enoyl-CoA hydratase; Provisional; Region: PRK05862
1229205017267	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1229205017268	substrate binding site [chemical binding]; other site
1229205017269	oxyanion hole (OAH) forming residues; other site
1229205017270	trimer interface [polypeptide binding]; other site
1229205017271	phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288
1229205017272	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1229205017273	NAD(P) binding site [chemical binding]; other site
1229205017274	catalytic residues [active]
1229205017275	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
1229205017276	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1229205017277	dimer interface [polypeptide binding]; other site
1229205017278	active site
1229205017279	enoyl-CoA hydratase; Provisional; Region: PRK08140
1229205017280	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1229205017281	substrate binding site [chemical binding]; other site
1229205017282	oxyanion hole (OAH) forming residues; other site
1229205017283	trimer interface [polypeptide binding]; other site
1229205017284	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1229205017285	CoenzymeA binding site [chemical binding]; other site
1229205017286	subunit interaction site [polypeptide binding]; other site
1229205017287	PHB binding site; other site
1229205017288	Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913
1229205017289	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
1229205017290	active site
1229205017291	AMP binding site [chemical binding]; other site
1229205017292	homodimer interface [polypeptide binding]; other site
1229205017293	acyl-activating enzyme (AAE) consensus motif; other site
1229205017294	CoA binding site [chemical binding]; other site
1229205017295	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
1229205017296	MltA specific insert domain; Region: MltA; smart00925
1229205017297	3D domain; Region: 3D; pfam06725
1229205017298	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
1229205017299	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1229205017300	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
1229205017301	substrate binding site [chemical binding]; other site
1229205017302	hexamer interface [polypeptide binding]; other site
1229205017303	metal binding site [ion binding]; metal-binding site
1229205017304	phosphoglycolate phosphatase; Provisional; Region: PRK13222
1229205017305	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229205017306	motif II; other site
1229205017307	anthranilate synthase component I; Provisional; Region: PRK13565
1229205017308	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1229205017309	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1229205017310	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
1229205017311	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1229205017312	glutamine binding [chemical binding]; other site
1229205017313	catalytic triad [active]
1229205017314	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1229205017315	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1229205017316	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1229205017317	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1229205017318	active site
1229205017319	ribulose/triose binding site [chemical binding]; other site
1229205017320	phosphate binding site [ion binding]; other site
1229205017321	substrate (anthranilate) binding pocket [chemical binding]; other site
1229205017322	product (indole) binding pocket [chemical binding]; other site
1229205017323	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
1229205017324	putative active site [active]
1229205017325	putative metal binding residues [ion binding]; other site
1229205017326	signature motif; other site
1229205017327	putative triphosphate binding site [ion binding]; other site
1229205017328	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1229205017329	ligand binding site [chemical binding]; other site
1229205017330	active site
1229205017331	UGI interface [polypeptide binding]; other site
1229205017332	catalytic site [active]
1229205017333	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1229205017334	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1229205017335	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
1229205017336	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
1229205017337	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1229205017338	protein binding site [polypeptide binding]; other site
1229205017339	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
1229205017340	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
1229205017341	dimerization domain [polypeptide binding]; other site
1229205017342	dimer interface [polypeptide binding]; other site
1229205017343	catalytic residues [active]
1229205017344	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608
1229205017345	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
1229205017346	GTP-binding protein YchF; Reviewed; Region: PRK09601
1229205017347	YchF GTPase; Region: YchF; cd01900
1229205017348	G1 box; other site
1229205017349	GTP/Mg2+ binding site [chemical binding]; other site
1229205017350	Switch I region; other site
1229205017351	G2 box; other site
1229205017352	Switch II region; other site
1229205017353	G3 box; other site
1229205017354	G4 box; other site
1229205017355	G5 box; other site
1229205017356	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1229205017357	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1229205017358	glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974
1229205017359	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205017360	dimer interface [polypeptide binding]; other site
1229205017361	conserved gate region; other site
1229205017362	putative PBP binding loops; other site
1229205017363	ABC-ATPase subunit interface; other site
1229205017364	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1229205017365	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205017366	dimer interface [polypeptide binding]; other site
1229205017367	conserved gate region; other site
1229205017368	putative PBP binding loops; other site
1229205017369	ABC-ATPase subunit interface; other site
1229205017370	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1229205017371	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1229205017372	Walker A/P-loop; other site
1229205017373	ATP binding site [chemical binding]; other site
1229205017374	Q-loop/lid; other site
1229205017375	ABC transporter signature motif; other site
1229205017376	Walker B; other site
1229205017377	D-loop; other site
1229205017378	H-loop/switch region; other site
1229205017379	TOBE domain; Region: TOBE_2; pfam08402
1229205017380	Protein of unknown function (DUF3761); Region: DUF3761; pfam12587
1229205017381	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
1229205017382	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229205017383	Walker A/P-loop; other site
1229205017384	ATP binding site [chemical binding]; other site
1229205017385	Q-loop/lid; other site
1229205017386	ABC transporter signature motif; other site
1229205017387	Walker B; other site
1229205017388	D-loop; other site
1229205017389	H-loop/switch region; other site
1229205017390	ABC transporter; Region: ABC_tran_2; pfam12848
1229205017391	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1229205017392	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
1229205017393	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1229205017394	?-D-glucose-1-phosphatase; Provisional; Region: PRK09456
1229205017395	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1229205017396	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1229205017397	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
1229205017398	active site
1229205017399	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1229205017400	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205017401	active site
1229205017402	dimerization interface [polypeptide binding]; other site
1229205017403	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229205017404	DNA binding site [nucleotide binding]
1229205017405	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
1229205017406	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
1229205017407	tRNA; other site
1229205017408	putative tRNA binding site [nucleotide binding]; other site
1229205017409	putative NADP binding site [chemical binding]; other site
1229205017410	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1229205017411	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1229205017412	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1229205017413	RF-1 domain; Region: RF-1; pfam00472
1229205017414	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1229205017415	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1229205017416	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
1229205017417	putative GSH binding site [chemical binding]; other site
1229205017418	catalytic residues [active]
1229205017419	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
1229205017420	Flavoprotein; Region: Flavoprotein; pfam02441
1229205017421	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
1229205017422	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
1229205017423	putative active site [active]
1229205017424	metal binding site [ion binding]; metal-binding site
1229205017425	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1229205017426	putative chaperone; Provisional; Region: PRK11678
1229205017427	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
1229205017428	nucleotide binding site [chemical binding]; other site
1229205017429	putative NEF/HSP70 interaction site [polypeptide binding]; other site
1229205017430	SBD interface [polypeptide binding]; other site
1229205017431	benzoate transport; Region: 2A0115; TIGR00895
1229205017432	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205017433	putative substrate translocation pore; other site
1229205017434	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205017435	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
1229205017436	putative FMN binding site [chemical binding]; other site
1229205017437	D-galactonate transporter; Region: 2A0114; TIGR00893
1229205017438	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205017439	putative substrate translocation pore; other site
1229205017440	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229205017441	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229205017442	Protein of unknown function (DUF1415); Region: DUF1415; pfam07209
1229205017443	Methyltransferase domain; Region: Methyltransf_32; pfam13679
1229205017444	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1229205017445	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1229205017446	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
1229205017447	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1229205017448	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229205017449	S-adenosylmethionine binding site [chemical binding]; other site
1229205017450	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
1229205017451	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1229205017452	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
1229205017453	dimer interface [polypeptide binding]; other site
1229205017454	N-terminal domain interface [polypeptide binding]; other site
1229205017455	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
1229205017456	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
1229205017457	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
1229205017458	Qi binding site; other site
1229205017459	intrachain domain interface; other site
1229205017460	interchain domain interface [polypeptide binding]; other site
1229205017461	heme bH binding site [chemical binding]; other site
1229205017462	heme bL binding site [chemical binding]; other site
1229205017463	Qo binding site; other site
1229205017464	interchain domain interface [polypeptide binding]; other site
1229205017465	intrachain domain interface; other site
1229205017466	Qi binding site; other site
1229205017467	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
1229205017468	Qo binding site; other site
1229205017469	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
1229205017470	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
1229205017471	[2Fe-2S] cluster binding site [ion binding]; other site
1229205017472	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
1229205017473	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1229205017474	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1229205017475	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1229205017476	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1229205017477	protein binding site [polypeptide binding]; other site
1229205017478	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
1229205017479	sec-independent translocase; Provisional; Region: tatB; PRK01919
1229205017480	twin arginine translocase protein A; Provisional; Region: tatA; PRK02958
1229205017481	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
1229205017482	nucleotide binding site/active site [active]
1229205017483	HIT family signature motif; other site
1229205017484	catalytic residue [active]
1229205017485	Predicted membrane protein [Function unknown]; Region: COG3671
1229205017486	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
1229205017487	metal binding site [ion binding]; metal-binding site
1229205017488	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
1229205017489	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1229205017490	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1229205017491	substrate binding site [chemical binding]; other site
1229205017492	glutamase interaction surface [polypeptide binding]; other site
1229205017493	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1229205017494	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1229205017495	catalytic residues [active]
1229205017496	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
1229205017497	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1229205017498	putative active site [active]
1229205017499	oxyanion strand; other site
1229205017500	catalytic triad [active]
1229205017501	MarC family integral membrane protein; Region: MarC; cl00919
1229205017502	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1229205017503	putative active site pocket [active]
1229205017504	4-fold oligomerization interface [polypeptide binding]; other site
1229205017505	metal binding residues [ion binding]; metal-binding site
1229205017506	3-fold/trimer interface [polypeptide binding]; other site
1229205017507	histidinol-phosphate aminotransferase; Provisional; Region: PRK04870
1229205017508	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229205017509	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205017510	homodimer interface [polypeptide binding]; other site
1229205017511	catalytic residue [active]
1229205017512	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
1229205017513	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1229205017514	NAD binding site [chemical binding]; other site
1229205017515	dimerization interface [polypeptide binding]; other site
1229205017516	product binding site; other site
1229205017517	substrate binding site [chemical binding]; other site
1229205017518	zinc binding site [ion binding]; other site
1229205017519	catalytic residues [active]
1229205017520	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
1229205017521	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
1229205017522	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1229205017523	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1229205017524	hinge; other site
1229205017525	active site
1229205017526	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
1229205017527	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1229205017528	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1229205017529	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1229205017530	Walker A/P-loop; other site
1229205017531	ATP binding site [chemical binding]; other site
1229205017532	Q-loop/lid; other site
1229205017533	ABC transporter signature motif; other site
1229205017534	Walker B; other site
1229205017535	D-loop; other site
1229205017536	H-loop/switch region; other site
1229205017537	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
1229205017538	VacJ like lipoprotein; Region: VacJ; cl01073
1229205017539	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
1229205017540	mce related protein; Region: MCE; pfam02470
1229205017541	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1229205017542	Permease; Region: Permease; pfam02405
1229205017543	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
1229205017544	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
1229205017545	Walker A/P-loop; other site
1229205017546	ATP binding site [chemical binding]; other site
1229205017547	Q-loop/lid; other site
1229205017548	ABC transporter signature motif; other site
1229205017549	Walker B; other site
1229205017550	D-loop; other site
1229205017551	H-loop/switch region; other site
1229205017552	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1229205017553	thiamine phosphate binding site [chemical binding]; other site
1229205017554	active site
1229205017555	pyrophosphate binding site [ion binding]; other site
1229205017556	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
1229205017557	ThiS interaction site; other site
1229205017558	putative active site [active]
1229205017559	tetramer interface [polypeptide binding]; other site
1229205017560	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
1229205017561	thiS-thiF/thiG interaction site; other site
1229205017562	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1229205017563	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
1229205017564	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
1229205017565	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
1229205017566	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
1229205017567	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
1229205017568	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205017569	NAD(P) binding site [chemical binding]; other site
1229205017570	active site
1229205017571	osmolarity response regulator; Provisional; Region: ompR; PRK09468
1229205017572	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205017573	active site
1229205017574	phosphorylation site [posttranslational modification]
1229205017575	intermolecular recognition site; other site
1229205017576	dimerization interface [polypeptide binding]; other site
1229205017577	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229205017578	DNA binding site [nucleotide binding]
1229205017579	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12696
1229205017580	Flagellar L-ring protein; Region: FlgH; pfam02107
1229205017581	osmolarity response regulator; Provisional; Region: ompR; PRK09468
1229205017582	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205017583	active site
1229205017584	phosphorylation site [posttranslational modification]
1229205017585	intermolecular recognition site; other site
1229205017586	dimerization interface [polypeptide binding]; other site
1229205017587	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229205017588	DNA binding site [nucleotide binding]
1229205017589	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1229205017590	dimerization interface [polypeptide binding]; other site
1229205017591	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205017592	dimer interface [polypeptide binding]; other site
1229205017593	phosphorylation site [posttranslational modification]
1229205017594	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205017595	ATP binding site [chemical binding]; other site
1229205017596	Mg2+ binding site [ion binding]; other site
1229205017597	G-X-G motif; other site
1229205017598	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
1229205017599	Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365
1229205017600	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
1229205017601	benzoate transport; Region: 2A0115; TIGR00895
1229205017602	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205017603	putative substrate translocation pore; other site
1229205017604	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
1229205017605	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1229205017606	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
1229205017607	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1229205017608	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1229205017609	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1229205017610	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1229205017611	active site
1229205017612	dimer interface [polypeptide binding]; other site
1229205017613	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1229205017614	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1229205017615	active site
1229205017616	FMN binding site [chemical binding]; other site
1229205017617	substrate binding site [chemical binding]; other site
1229205017618	3Fe-4S cluster binding site [ion binding]; other site
1229205017619	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
1229205017620	domain interface; other site
1229205017621	Transposase IS200 like; Region: Y1_Tnp; cl00848
1229205017622	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
1229205017623	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
1229205017624	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
1229205017625	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1229205017626	Zn2+ binding site [ion binding]; other site
1229205017627	Mg2+ binding site [ion binding]; other site
1229205017628	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
1229205017629	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1229205017630	active site
1229205017631	dimer interface [polypeptide binding]; other site
1229205017632	metal binding site [ion binding]; metal-binding site
1229205017633	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1229205017634	Shikimate kinase; Region: SKI; pfam01202
1229205017635	magnesium binding site [ion binding]; other site
1229205017636	putative shikimate binding site; other site
1229205017637	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
1229205017638	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1229205017639	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1229205017640	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
1229205017641	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
1229205017642	Transglycosylase; Region: Transgly; pfam00912
1229205017643	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1229205017644	frataxin-like protein; Provisional; Region: cyaY; PRK00446
1229205017645	diaminopimelate decarboxylase; Region: lysA; TIGR01048
1229205017646	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1229205017647	active site
1229205017648	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1229205017649	substrate binding site [chemical binding]; other site
1229205017650	catalytic residues [active]
1229205017651	dimer interface [polypeptide binding]; other site
1229205017652	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
1229205017653	TMAO/DMSO reductase; Reviewed; Region: PRK05363
1229205017654	YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107
1229205017655	Moco binding site; other site
1229205017656	metal coordination site [ion binding]; other site
1229205017657	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
1229205017658	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
1229205017659	ResB-like family; Region: ResB; pfam05140
1229205017660	Cytochrome c553 [Energy production and conversion]; Region: COG2863
1229205017661	Cytochrome c; Region: Cytochrom_C; cl11414
1229205017662	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1229205017663	G1 box; other site
1229205017664	GTP/Mg2+ binding site [chemical binding]; other site
1229205017665	Switch I region; other site
1229205017666	G2 box; other site
1229205017667	G3 box; other site
1229205017668	Switch II region; other site
1229205017669	G4 box; other site
1229205017670	G5 box; other site
1229205017671	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
1229205017672	dimer interface [polypeptide binding]; other site
1229205017673	active site
1229205017674	aspartate-rich active site metal binding site; other site
1229205017675	allosteric magnesium binding site [ion binding]; other site
1229205017676	Schiff base residues; other site
1229205017677	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
1229205017678	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
1229205017679	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1229205017680	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
1229205017681	DsbD alpha interface [polypeptide binding]; other site
1229205017682	catalytic residues [active]
1229205017683	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
1229205017684	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1229205017685	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1229205017686	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1229205017687	alphaNTD homodimer interface [polypeptide binding]; other site
1229205017688	alphaNTD - beta interaction site [polypeptide binding]; other site
1229205017689	alphaNTD - beta' interaction site [polypeptide binding]; other site
1229205017690	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1229205017691	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1229205017692	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1229205017693	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1229205017694	RNA binding surface [nucleotide binding]; other site
1229205017695	30S ribosomal protein S11; Validated; Region: PRK05309
1229205017696	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1229205017697	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1229205017698	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1229205017699	rRNA binding site [nucleotide binding]; other site
1229205017700	predicted 30S ribosome binding site; other site
1229205017701	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1229205017702	SecY translocase; Region: SecY; pfam00344
1229205017703	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1229205017704	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1229205017705	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1229205017706	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1229205017707	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1229205017708	5S rRNA interface [nucleotide binding]; other site
1229205017709	L27 interface [polypeptide binding]; other site
1229205017710	23S rRNA interface [nucleotide binding]; other site
1229205017711	L5 interface [polypeptide binding]; other site
1229205017712	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1229205017713	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1229205017714	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1229205017715	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1229205017716	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1229205017717	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1229205017718	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1229205017719	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1229205017720	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1229205017721	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1229205017722	RNA binding site [nucleotide binding]; other site
1229205017723	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1229205017724	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1229205017725	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1229205017726	23S rRNA interface [nucleotide binding]; other site
1229205017727	5S rRNA interface [nucleotide binding]; other site
1229205017728	putative antibiotic binding site [chemical binding]; other site
1229205017729	L25 interface [polypeptide binding]; other site
1229205017730	L27 interface [polypeptide binding]; other site
1229205017731	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1229205017732	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1229205017733	G-X-X-G motif; other site
1229205017734	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1229205017735	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1229205017736	putative translocon binding site; other site
1229205017737	protein-rRNA interface [nucleotide binding]; other site
1229205017738	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1229205017739	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1229205017740	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1229205017741	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1229205017742	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1229205017743	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1229205017744	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1229205017745	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1229205017746	elongation factor G; Reviewed; Region: PRK00007
1229205017747	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1229205017748	G1 box; other site
1229205017749	putative GEF interaction site [polypeptide binding]; other site
1229205017750	GTP/Mg2+ binding site [chemical binding]; other site
1229205017751	Switch I region; other site
1229205017752	G2 box; other site
1229205017753	G3 box; other site
1229205017754	Switch II region; other site
1229205017755	G4 box; other site
1229205017756	G5 box; other site
1229205017757	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1229205017758	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1229205017759	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1229205017760	30S ribosomal protein S7; Validated; Region: PRK05302
1229205017761	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1229205017762	S17 interaction site [polypeptide binding]; other site
1229205017763	S8 interaction site; other site
1229205017764	16S rRNA interaction site [nucleotide binding]; other site
1229205017765	streptomycin interaction site [chemical binding]; other site
1229205017766	23S rRNA interaction site [nucleotide binding]; other site
1229205017767	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1229205017768	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
1229205017769	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1229205017770	ATP binding site [chemical binding]; other site
1229205017771	putative Mg++ binding site [ion binding]; other site
1229205017772	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1229205017773	nucleotide binding region [chemical binding]; other site
1229205017774	ATP-binding site [chemical binding]; other site
1229205017775	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
1229205017776	HRDC domain; Region: HRDC; pfam00570
1229205017777	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
1229205017778	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1229205017779	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1229205017780	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1229205017781	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1229205017782	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
1229205017783	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1229205017784	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
1229205017785	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1229205017786	DNA binding site [nucleotide binding]
1229205017787	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1229205017788	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1229205017789	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1229205017790	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1229205017791	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1229205017792	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
1229205017793	RPB12 interaction site [polypeptide binding]; other site
1229205017794	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1229205017795	RPB3 interaction site [polypeptide binding]; other site
1229205017796	RPB1 interaction site [polypeptide binding]; other site
1229205017797	RPB11 interaction site [polypeptide binding]; other site
1229205017798	RPB10 interaction site [polypeptide binding]; other site
1229205017799	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1229205017800	peripheral dimer interface [polypeptide binding]; other site
1229205017801	core dimer interface [polypeptide binding]; other site
1229205017802	L10 interface [polypeptide binding]; other site
1229205017803	L11 interface [polypeptide binding]; other site
1229205017804	putative EF-Tu interaction site [polypeptide binding]; other site
1229205017805	putative EF-G interaction site [polypeptide binding]; other site
1229205017806	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1229205017807	23S rRNA interface [nucleotide binding]; other site
1229205017808	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1229205017809	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1229205017810	mRNA/rRNA interface [nucleotide binding]; other site
1229205017811	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1229205017812	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1229205017813	23S rRNA interface [nucleotide binding]; other site
1229205017814	L7/L12 interface [polypeptide binding]; other site
1229205017815	putative thiostrepton binding site; other site
1229205017816	L25 interface [polypeptide binding]; other site
1229205017817	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1229205017818	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1229205017819	putative homodimer interface [polypeptide binding]; other site
1229205017820	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1229205017821	heterodimer interface [polypeptide binding]; other site
1229205017822	homodimer interface [polypeptide binding]; other site
1229205017823	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
1229205017824	elongation factor Tu; Reviewed; Region: PRK00049
1229205017825	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1229205017826	G1 box; other site
1229205017827	GEF interaction site [polypeptide binding]; other site
1229205017828	GTP/Mg2+ binding site [chemical binding]; other site
1229205017829	Switch I region; other site
1229205017830	G2 box; other site
1229205017831	G3 box; other site
1229205017832	Switch II region; other site
1229205017833	G4 box; other site
1229205017834	G5 box; other site
1229205017835	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1229205017836	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1229205017837	Antibiotic Binding Site [chemical binding]; other site
1229205017838	SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830
1229205017839	active site
1229205017840	catalytic triad [active]
1229205017841	oxyanion hole [active]
1229205017842	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
1229205017843	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1229205017844	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
1229205017845	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
1229205017846	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
1229205017847	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
1229205017848	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1229205017849	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
1229205017850	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
1229205017851	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
1229205017852	FAD binding pocket [chemical binding]; other site
1229205017853	FAD binding motif [chemical binding]; other site
1229205017854	phosphate binding motif [ion binding]; other site
1229205017855	beta-alpha-beta structure motif; other site
1229205017856	NAD(p) ribose binding residues [chemical binding]; other site
1229205017857	NAD binding pocket [chemical binding]; other site
1229205017858	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
1229205017859	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1229205017860	catalytic loop [active]
1229205017861	iron binding site [ion binding]; other site
1229205017862	Domain of unknown function (DUF1835); Region: DUF1835; pfam08874
1229205017863	Protein of unknown function; Region: DUF3658; pfam12395
1229205017864	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229205017865	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229205017866	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1229205017867	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229205017868	Coenzyme A binding pocket [chemical binding]; other site
1229205017869	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1229205017870	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1229205017871	putative DNA binding site [nucleotide binding]; other site
1229205017872	putative Zn2+ binding site [ion binding]; other site
1229205017873	AsnC family; Region: AsnC_trans_reg; pfam01037
1229205017874	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
1229205017875	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
1229205017876	dimer interface [polypeptide binding]; other site
1229205017877	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
1229205017878	active site
1229205017879	Fe binding site [ion binding]; other site
1229205017880	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
1229205017881	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1229205017882	dimer interface [polypeptide binding]; other site
1229205017883	PYR/PP interface [polypeptide binding]; other site
1229205017884	TPP binding site [chemical binding]; other site
1229205017885	substrate binding site [chemical binding]; other site
1229205017886	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
1229205017887	TPP-binding site; other site
1229205017888	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
1229205017889	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
1229205017890	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1229205017891	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1229205017892	putative NAD(P) binding site [chemical binding]; other site
1229205017893	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
1229205017894	benzoate transport; Region: 2A0115; TIGR00895
1229205017895	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205017896	putative substrate translocation pore; other site
1229205017897	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1229205017898	active site
1229205017899	transcriptional regulator RcsB; Provisional; Region: PRK10840
1229205017900	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205017901	active site
1229205017902	phosphorylation site [posttranslational modification]
1229205017903	intermolecular recognition site; other site
1229205017904	dimerization interface [polypeptide binding]; other site
1229205017905	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1229205017906	DNA binding residues [nucleotide binding]
1229205017907	dimerization interface [polypeptide binding]; other site
1229205017908	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1229205017909	substrate binding site [chemical binding]; other site
1229205017910	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
1229205017911	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1229205017912	Protein of unknown function (DUF2957); Region: DUF2957; pfam11170
1229205017913	Protein of unknown function (DUF2957); Region: DUF2957; pfam11170
1229205017914	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
1229205017915	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1229205017916	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1229205017917	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1229205017918	Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451
1229205017919	Uncharacterized conserved protein [Function unknown]; Region: COG1656
1229205017920	Protein of unknown function DUF82; Region: DUF82; pfam01927
1229205017921	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
1229205017922	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1229205017923	Bacterial transcriptional regulator; Region: IclR; pfam01614
1229205017924	Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001
1229205017925	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1229205017926	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1229205017927	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1229205017928	catalytic residue [active]
1229205017929	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1229205017930	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1229205017931	glutaminase active site [active]
1229205017932	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1229205017933	dimer interface [polypeptide binding]; other site
1229205017934	active site
1229205017935	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1229205017936	dimer interface [polypeptide binding]; other site
1229205017937	active site
1229205017938	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
1229205017939	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1229205017940	Substrate binding site; other site
1229205017941	Mg++ binding site; other site
1229205017942	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1229205017943	active site
1229205017944	substrate binding site [chemical binding]; other site
1229205017945	CoA binding site [chemical binding]; other site
1229205017946	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
1229205017947	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
1229205017948	Ligand Binding Site [chemical binding]; other site
1229205017949	Dihydroneopterin aldolase; Region: FolB; smart00905
1229205017950	active site
1229205017951	short chain dehydrogenase; Provisional; Region: PRK09134
1229205017952	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205017953	NAD(P) binding site [chemical binding]; other site
1229205017954	active site
1229205017955	Uncharacterized conserved protein [Function unknown]; Region: COG1565
1229205017956	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
1229205017957	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1229205017958	active site
1229205017959	NTP binding site [chemical binding]; other site
1229205017960	metal binding triad [ion binding]; metal-binding site
1229205017961	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1229205017962	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1229205017963	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
1229205017964	putative C-terminal domain interface [polypeptide binding]; other site
1229205017965	putative GSH binding site (G-site) [chemical binding]; other site
1229205017966	putative dimer interface [polypeptide binding]; other site
1229205017967	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
1229205017968	putative dimer interface [polypeptide binding]; other site
1229205017969	putative N-terminal domain interface [polypeptide binding]; other site
1229205017970	putative substrate binding pocket (H-site) [chemical binding]; other site
1229205017971	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
1229205017972	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1229205017973	putative NAD(P) binding site [chemical binding]; other site
1229205017974	active site
1229205017975	lytic murein transglycosylase; Provisional; Region: PRK11619
1229205017976	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1229205017977	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1229205017978	catalytic residue [active]
1229205017979	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
1229205017980	MarR family; Region: MarR_2; cl17246
1229205017981	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
1229205017982	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
1229205017983	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
1229205017984	Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800
1229205017985	putative active site [active]
1229205017986	Protein of unknown function (DUF969); Region: DUF969; pfam06149
1229205017987	Predicted membrane protein [Function unknown]; Region: COG3817
1229205017988	Protein of unknown function (DUF979); Region: DUF979; pfam06166
1229205017989	TPR repeat; Region: TPR_11; pfam13414
1229205017990	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229205017991	binding surface
1229205017992	TPR motif; other site
1229205017993	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229205017994	binding surface
1229205017995	TPR repeat; Region: TPR_11; pfam13414
1229205017996	TPR motif; other site
1229205017997	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1229205017998	Tetratricopeptide repeat; Region: TPR_17; pfam13431
1229205017999	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1229205018000	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
1229205018001	PemK-like protein; Region: PemK; cl00995
1229205018002	TraB family; Region: TraB; pfam01963
1229205018003	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
1229205018004	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1229205018005	Walker A/P-loop; other site
1229205018006	ATP binding site [chemical binding]; other site
1229205018007	Q-loop/lid; other site
1229205018008	ABC transporter signature motif; other site
1229205018009	Walker B; other site
1229205018010	D-loop; other site
1229205018011	H-loop/switch region; other site
1229205018012	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1229205018013	dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022
1229205018014	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1229205018015	Walker A/P-loop; other site
1229205018016	ATP binding site [chemical binding]; other site
1229205018017	Q-loop/lid; other site
1229205018018	ABC transporter signature motif; other site
1229205018019	Walker B; other site
1229205018020	D-loop; other site
1229205018021	H-loop/switch region; other site
1229205018022	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1229205018023	dipeptide transporter; Provisional; Region: PRK10913
1229205018024	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205018025	dimer interface [polypeptide binding]; other site
1229205018026	conserved gate region; other site
1229205018027	putative PBP binding loops; other site
1229205018028	ABC-ATPase subunit interface; other site
1229205018029	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1229205018030	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205018031	dimer interface [polypeptide binding]; other site
1229205018032	conserved gate region; other site
1229205018033	putative PBP binding loops; other site
1229205018034	ABC-ATPase subunit interface; other site
1229205018035	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1229205018036	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
1229205018037	peptide binding site [polypeptide binding]; other site
1229205018038	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1229205018039	FAD binding site [chemical binding]; other site
1229205018040	Membrane protein of unknown function; Region: DUF360; pfam04020
1229205018041	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
1229205018042	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
1229205018043	homotetramer interface [polypeptide binding]; other site
1229205018044	ligand binding site [chemical binding]; other site
1229205018045	catalytic site [active]
1229205018046	NAD binding site [chemical binding]; other site
1229205018047	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1229205018048	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1229205018049	active site
1229205018050	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205018051	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205018052	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
1229205018053	putative dimerization interface [polypeptide binding]; other site
1229205018054	choline dehydrogenase; Validated; Region: PRK02106
1229205018055	lycopene cyclase; Region: lycopene_cycl; TIGR01789
1229205018056	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1229205018057	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
1229205018058	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1229205018059	active site
1229205018060	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
1229205018061	NAD(P) binding site [chemical binding]; other site
1229205018062	catalytic residues [active]
1229205018063	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
1229205018064	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
1229205018065	Flagellar protein FliT; Region: FliT; cl05125
1229205018066	Flagellar protein FliS; Region: FliS; cl00654
1229205018067	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
1229205018068	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
1229205018069	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
1229205018070	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
1229205018071	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
1229205018072	FliG C-terminal domain; Region: FliG_C; pfam01706
1229205018073	flagellar assembly protein H; Validated; Region: fliH; PRK05687
1229205018074	Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811
1229205018075	Flagellar assembly protein FliH; Region: FliH; pfam02108
1229205018076	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
1229205018077	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
1229205018078	Walker A motif/ATP binding site; other site
1229205018079	Walker B motif; other site
1229205018080	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
1229205018081	Flagellar FliJ protein; Region: FliJ; pfam02050
1229205018082	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
1229205018083	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021
1229205018084	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
1229205018085	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
1229205018086	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
1229205018087	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
1229205018088	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
1229205018089	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
1229205018090	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
1229205018091	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870
1229205018092	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1229205018093	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945
1229205018094	Flagellar regulator YcgR; Region: YcgR; pfam07317
1229205018095	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
1229205018096	PilZ domain; Region: PilZ; pfam07238
1229205018097	flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12709
1229205018098	Rod binding protein; Region: Rod-binding; cl01626
1229205018099	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
1229205018100	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
1229205018101	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
1229205018102	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12697
1229205018103	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
1229205018104	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12694
1229205018105	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1229205018106	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1229205018107	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
1229205018108	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1229205018109	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
1229205018110	flagellar hook protein FlgE; Provisional; Region: flgE; PRK12637
1229205018111	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
1229205018112	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1229205018113	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
1229205018114	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
1229205018115	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
1229205018116	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
1229205018117	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1229205018118	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1229205018119	flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12626
1229205018120	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
1229205018121	SAF-like; Region: SAF_2; pfam13144
1229205018122	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
1229205018123	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
1229205018124	Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052
1229205018125	FlgN protein; Region: FlgN; pfam05130
1229205018126	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
1229205018127	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1229205018128	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
1229205018129	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1229205018130	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1229205018131	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1229205018132	DNA binding residues [nucleotide binding]
1229205018133	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
1229205018134	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1229205018135	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1229205018136	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14722
1229205018137	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1229205018138	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
1229205018139	FHIPEP family; Region: FHIPEP; pfam00771
1229205018140	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
1229205018141	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
1229205018142	Protein of unknown function (DUF3443); Region: DUF3443; pfam11925
1229205018143	Protein of unknown function (DUF2844); Region: DUF2844; pfam11005
1229205018144	chemotaxis regulator CheZ; Provisional; Region: PRK11166
1229205018145	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
1229205018146	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205018147	active site
1229205018148	phosphorylation site [posttranslational modification]
1229205018149	intermolecular recognition site; other site
1229205018150	dimerization interface [polypeptide binding]; other site
1229205018151	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
1229205018152	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205018153	active site
1229205018154	phosphorylation site [posttranslational modification]
1229205018155	intermolecular recognition site; other site
1229205018156	dimerization interface [polypeptide binding]; other site
1229205018157	CheB methylesterase; Region: CheB_methylest; pfam01339
1229205018158	chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13489
1229205018159	chemotaxis methyltransferase CheR; Provisional; Region: PRK10611
1229205018160	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1229205018161	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
1229205018162	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
1229205018163	dimer interface [polypeptide binding]; other site
1229205018164	ligand binding site [chemical binding]; other site
1229205018165	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1229205018166	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1229205018167	dimerization interface [polypeptide binding]; other site
1229205018168	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1229205018169	dimer interface [polypeptide binding]; other site
1229205018170	putative CheW interface [polypeptide binding]; other site
1229205018171	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
1229205018172	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1229205018173	putative binding surface; other site
1229205018174	active site
1229205018175	CheY binding; Region: CheY-binding; pfam09078
1229205018176	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
1229205018177	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205018178	ATP binding site [chemical binding]; other site
1229205018179	Mg2+ binding site [ion binding]; other site
1229205018180	G-X-G motif; other site
1229205018181	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
1229205018182	Response regulator receiver domain; Region: Response_reg; pfam00072
1229205018183	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205018184	active site
1229205018185	phosphorylation site [posttranslational modification]
1229205018186	intermolecular recognition site; other site
1229205018187	dimerization interface [polypeptide binding]; other site
1229205018188	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
1229205018189	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
1229205018190	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1229205018191	ligand binding site [chemical binding]; other site
1229205018192	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
1229205018193	flagellar motor protein MotA; Validated; Region: PRK09110
1229205018194	transcriptional activator FlhC; Provisional; Region: PRK12722
1229205018195	transcriptional activator FlhD; Provisional; Region: PRK02909
1229205018196	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229205018197	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
1229205018198	putative ADP-binding pocket [chemical binding]; other site
1229205018199	H-NS histone family; Region: Histone_HNS; pfam00816
1229205018200	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
1229205018201	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
1229205018202	amphipathic channel; other site
1229205018203	Asn-Pro-Ala signature motifs; other site
1229205018204	putative hydrolase; Provisional; Region: PRK10976
1229205018205	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229205018206	active site
1229205018207	motif I; other site
1229205018208	motif II; other site
1229205018209	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1229205018210	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
1229205018211	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1229205018212	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1229205018213	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1229205018214	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1229205018215	active site
1229205018216	catalytic tetrad [active]
1229205018217	flagellin; Reviewed; Region: PRK08869
1229205018218	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1229205018219	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1229205018220	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
1229205018221	TPR repeat; Region: TPR_11; pfam13414
1229205018222	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229205018223	TPR motif; other site
1229205018224	binding surface
1229205018225	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229205018226	TPR motif; other site
1229205018227	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229205018228	TPR motif; other site
1229205018229	binding surface
1229205018230	TPR repeat; Region: TPR_11; pfam13414
1229205018231	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229205018232	TPR motif; other site
1229205018233	binding surface
1229205018234	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
1229205018235	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1229205018236	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1229205018237	inhibitor-cofactor binding pocket; inhibition site
1229205018238	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205018239	catalytic residue [active]
1229205018240	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1229205018241	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1229205018242	dimer interface [polypeptide binding]; other site
1229205018243	active site
1229205018244	CoA binding pocket [chemical binding]; other site
1229205018245	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
1229205018246	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
1229205018247	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1229205018248	dimer interface [polypeptide binding]; other site
1229205018249	active site
1229205018250	CoA binding pocket [chemical binding]; other site
1229205018251	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1229205018252	classical (c) SDRs; Region: SDR_c; cd05233
1229205018253	NAD(P) binding site [chemical binding]; other site
1229205018254	active site
1229205018255	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
1229205018256	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
1229205018257	putative trimer interface [polypeptide binding]; other site
1229205018258	putative CoA binding site [chemical binding]; other site
1229205018259	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1229205018260	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1229205018261	[2Fe-2S] cluster binding site [ion binding]; other site
1229205018262	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
1229205018263	alpha subunit interface [polypeptide binding]; other site
1229205018264	active site
1229205018265	substrate binding site [chemical binding]; other site
1229205018266	Fe binding site [ion binding]; other site
1229205018267	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1229205018268	Methyltransferase domain; Region: Methyltransf_11; pfam08241
1229205018269	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
1229205018270	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1229205018271	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1229205018272	active site
1229205018273	catalytic residues [active]
1229205018274	DNA binding site [nucleotide binding]
1229205018275	Int/Topo IB signature motif; other site
1229205018276	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
1229205018277	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229205018278	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205018279	ATP binding site [chemical binding]; other site
1229205018280	Mg2+ binding site [ion binding]; other site
1229205018281	G-X-G motif; other site
1229205018282	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
1229205018283	Protein of unknown function (DUF4007); Region: DUF4007; pfam13182
1229205018284	phage/plasmid-like protein TIGR03299; Region: LGT_TIGR03299
1229205018285	YqaJ-like viral recombinase domain; Region: YqaJ; cl09232
1229205018286	Src Homology 3 domain superfamily; Region: SH3; cl17036
1229205018287	peptide ligand binding site [polypeptide binding]; other site
1229205018288	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1229205018289	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229205018290	non-specific DNA binding site [nucleotide binding]; other site
1229205018291	salt bridge; other site
1229205018292	sequence-specific DNA binding site [nucleotide binding]; other site
1229205018293	Protein of unknown function (DUF3296); Region: DUF3296; pfam11726
1229205018294	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
1229205018295	Protein of unknown function DUF91; Region: DUF91; cl00709
1229205018296	Cytochrome c; Region: Cytochrom_C; cl11414
1229205018297	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1229205018298	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
1229205018299	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
1229205018300	Part of AAA domain; Region: AAA_19; pfam13245
1229205018301	Family description; Region: UvrD_C_2; pfam13538
1229205018302	putative oxidoreductase; Provisional; Region: PRK11579
1229205018303	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1229205018304	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1229205018305	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
1229205018306	POPLD (NUC188) domain; Region: POPLD; pfam08170
1229205018307	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1229205018308	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1229205018309	lipoyl attachment site [posttranslational modification]; other site
1229205018310	glycine dehydrogenase; Provisional; Region: PRK05367
1229205018311	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1229205018312	tetramer interface [polypeptide binding]; other site
1229205018313	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205018314	catalytic residue [active]
1229205018315	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1229205018316	tetramer interface [polypeptide binding]; other site
1229205018317	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205018318	catalytic residue [active]
1229205018319	Alginate lyase; Region: Alginate_lyase; pfam05426
1229205018320	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
1229205018321	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1229205018322	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1229205018323	thiamine pyrophosphate protein; Validated; Region: PRK08199
1229205018324	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1229205018325	PYR/PP interface [polypeptide binding]; other site
1229205018326	dimer interface [polypeptide binding]; other site
1229205018327	TPP binding site [chemical binding]; other site
1229205018328	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1229205018329	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
1229205018330	TPP-binding site [chemical binding]; other site
1229205018331	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1229205018332	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1229205018333	dimerization interface [polypeptide binding]; other site
1229205018334	ligand binding site [chemical binding]; other site
1229205018335	trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809
1229205018336	Predicted transcriptional regulator [Transcription]; Region: COG3905
1229205018337	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
1229205018338	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
1229205018339	Glutamate binding site [chemical binding]; other site
1229205018340	NAD binding site [chemical binding]; other site
1229205018341	catalytic residues [active]
1229205018342	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1229205018343	primosome assembly protein PriA; Validated; Region: PRK05580
1229205018344	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1229205018345	ATP binding site [chemical binding]; other site
1229205018346	putative Mg++ binding site [ion binding]; other site
1229205018347	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1229205018348	ATP-binding site [chemical binding]; other site
1229205018349	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
1229205018350	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1229205018351	substrate binding site [chemical binding]; other site
1229205018352	active site
1229205018353	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1229205018354	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229205018355	substrate binding pocket [chemical binding]; other site
1229205018356	membrane-bound complex binding site; other site
1229205018357	hinge residues; other site
1229205018358	AMP-binding domain protein; Validated; Region: PRK08315
1229205018359	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1229205018360	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
1229205018361	acyl-activating enzyme (AAE) consensus motif; other site
1229205018362	putative AMP binding site [chemical binding]; other site
1229205018363	putative active site [active]
1229205018364	putative CoA binding site [chemical binding]; other site
1229205018365	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
1229205018366	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1229205018367	gamma subunit interface [polypeptide binding]; other site
1229205018368	epsilon subunit interface [polypeptide binding]; other site
1229205018369	LBP interface [polypeptide binding]; other site
1229205018370	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1229205018371	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1229205018372	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1229205018373	alpha subunit interaction interface [polypeptide binding]; other site
1229205018374	Walker A motif; other site
1229205018375	ATP binding site [chemical binding]; other site
1229205018376	Walker B motif; other site
1229205018377	inhibitor binding site; inhibition site
1229205018378	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1229205018379	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1229205018380	core domain interface [polypeptide binding]; other site
1229205018381	delta subunit interface [polypeptide binding]; other site
1229205018382	epsilon subunit interface [polypeptide binding]; other site
1229205018383	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1229205018384	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1229205018385	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1229205018386	beta subunit interaction interface [polypeptide binding]; other site
1229205018387	Walker A motif; other site
1229205018388	ATP binding site [chemical binding]; other site
1229205018389	Walker B motif; other site
1229205018390	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1229205018391	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
1229205018392	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1229205018393	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1229205018394	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1229205018395	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
1229205018396	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1229205018397	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1229205018398	ATP synthase I chain; Region: ATP_synt_I; pfam03899
1229205018399	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1229205018400	ParB-like nuclease domain; Region: ParBc; pfam02195
1229205018401	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1229205018402	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1229205018403	P-loop; other site
1229205018404	Magnesium ion binding site [ion binding]; other site
1229205018405	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1229205018406	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1229205018407	Magnesium ion binding site [ion binding]; other site
1229205018408	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1229205018409	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229205018410	S-adenosylmethionine binding site [chemical binding]; other site
1229205018411	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1229205018412	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
1229205018413	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1229205018414	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1229205018415	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1229205018416	Walker A/P-loop; other site
1229205018417	ATP binding site [chemical binding]; other site
1229205018418	Q-loop/lid; other site
1229205018419	ABC transporter signature motif; other site
1229205018420	Walker B; other site
1229205018421	D-loop; other site
1229205018422	H-loop/switch region; other site
1229205018423	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1229205018424	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1229205018425	TM-ABC transporter signature motif; other site
1229205018426	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1229205018427	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1229205018428	Walker A/P-loop; other site
1229205018429	ATP binding site [chemical binding]; other site
1229205018430	Q-loop/lid; other site
1229205018431	ABC transporter signature motif; other site
1229205018432	Walker B; other site
1229205018433	D-loop; other site
1229205018434	H-loop/switch region; other site
1229205018435	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1229205018436	TM-ABC transporter signature motif; other site
1229205018437	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1229205018438	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
1229205018439	putative ligand binding site [chemical binding]; other site
1229205018440	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1229205018441	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
1229205018442	putative ligand binding site [chemical binding]; other site
1229205018443	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1229205018444	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1229205018445	TM-ABC transporter signature motif; other site
1229205018446	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1229205018447	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1229205018448	TM-ABC transporter signature motif; other site
1229205018449	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1229205018450	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
1229205018451	putative ligand binding site [chemical binding]; other site
1229205018452	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1229205018453	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1229205018454	Walker A/P-loop; other site
1229205018455	ATP binding site [chemical binding]; other site
1229205018456	Q-loop/lid; other site
1229205018457	ABC transporter signature motif; other site
1229205018458	Walker B; other site
1229205018459	D-loop; other site
1229205018460	H-loop/switch region; other site
1229205018461	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1229205018462	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1229205018463	Walker A/P-loop; other site
1229205018464	ATP binding site [chemical binding]; other site
1229205018465	Q-loop/lid; other site
1229205018466	ABC transporter signature motif; other site
1229205018467	Walker B; other site
1229205018468	D-loop; other site
1229205018469	H-loop/switch region; other site
1229205018470	choline dehydrogenase; Validated; Region: PRK02106
1229205018471	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1229205018472	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1229205018473	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
1229205018474	tetrameric interface [polypeptide binding]; other site
1229205018475	NAD binding site [chemical binding]; other site
1229205018476	catalytic residues [active]
1229205018477	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205018478	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
1229205018479	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1229205018480	dimerization interface [polypeptide binding]; other site
1229205018481	Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890
1229205018482	putative active site [active]
1229205018483	putative metal binding residues [ion binding]; other site
1229205018484	signature motif; other site
1229205018485	putative triphosphate binding site [ion binding]; other site
1229205018486	dimer interface [polypeptide binding]; other site
1229205018487	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1229205018488	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
1229205018489	AsnC family; Region: AsnC_trans_reg; pfam01037
1229205018490	Protein of unknown function (DUF3717); Region: DUF3717; pfam12512
1229205018491	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1229205018492	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205018493	active site
1229205018494	phosphorylation site [posttranslational modification]
1229205018495	intermolecular recognition site; other site
1229205018496	dimerization interface [polypeptide binding]; other site
1229205018497	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229205018498	DNA binding site [nucleotide binding]
1229205018499	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
1229205018500	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229205018501	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1229205018502	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205018503	dimer interface [polypeptide binding]; other site
1229205018504	phosphorylation site [posttranslational modification]
1229205018505	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205018506	ATP binding site [chemical binding]; other site
1229205018507	Mg2+ binding site [ion binding]; other site
1229205018508	G-X-G motif; other site
1229205018509	Proteins containing SET domain [General function prediction only]; Region: COG2940
1229205018510	SET domain; Region: SET; pfam00856
1229205018511	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1229205018512	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
1229205018513	active site
1229205018514	FMN binding site [chemical binding]; other site
1229205018515	substrate binding site [chemical binding]; other site
1229205018516	homotetramer interface [polypeptide binding]; other site
1229205018517	catalytic residue [active]
1229205018518	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
1229205018519	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
1229205018520	catalytic triad [active]
1229205018521	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1229205018522	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1229205018523	putative DNA binding site [nucleotide binding]; other site
1229205018524	putative Zn2+ binding site [ion binding]; other site
1229205018525	gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516
1229205018526	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
1229205018527	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1229205018528	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
1229205018529	Uncharacterized conserved protein [Function unknown]; Region: COG4121
1229205018530	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1229205018531	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1229205018532	IHF dimer interface [polypeptide binding]; other site
1229205018533	IHF - DNA interface [nucleotide binding]; other site
1229205018534	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1229205018535	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1229205018536	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1229205018537	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1229205018538	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1229205018539	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1229205018540	catalytic residue [active]
1229205018541	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1229205018542	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1229205018543	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1229205018544	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
1229205018545	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1229205018546	type II secretion system protein E; Region: type_II_gspE; TIGR02533
1229205018547	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
1229205018548	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
1229205018549	Walker A motif; other site
1229205018550	ATP binding site [chemical binding]; other site
1229205018551	Walker B motif; other site
1229205018552	type II secretion system protein F; Region: GspF; TIGR02120
1229205018553	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1229205018554	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1229205018555	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
1229205018556	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
1229205018557	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
1229205018558	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
1229205018559	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
1229205018560	Type II transport protein GspH; Region: GspH; pfam12019
1229205018561	type II secretion system protein I; Region: gspI; TIGR01707
1229205018562	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
1229205018563	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
1229205018564	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
1229205018565	GspL periplasmic domain; Region: GspL_C; pfam12693
1229205018566	Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612
1229205018567	Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203
1229205018568	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1229205018569	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1229205018570	MarR family; Region: MarR_2; cl17246
1229205018571	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1229205018572	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205018573	putative substrate translocation pore; other site
1229205018574	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205018575	glutamate--cysteine ligase; Provisional; Region: PRK02107
1229205018576	AlkA N-terminal domain; Region: AlkA_N; pfam06029
1229205018577	3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308
1229205018578	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1229205018579	minor groove reading motif; other site
1229205018580	helix-hairpin-helix signature motif; other site
1229205018581	substrate binding pocket [chemical binding]; other site
1229205018582	active site
1229205018583	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
1229205018584	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
1229205018585	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205018586	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1229205018587	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1229205018588	DNA binding site [nucleotide binding]
1229205018589	active site
1229205018590	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
1229205018591	dimer interface [polypeptide binding]; other site
1229205018592	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1229205018593	metal binding site [ion binding]; metal-binding site
1229205018594	YaeQ protein; Region: YaeQ; pfam07152
1229205018595	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205018596	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205018597	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
1229205018598	putative dimerization interface [polypeptide binding]; other site
1229205018599	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1229205018600	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1229205018601	NAD(P) binding site [chemical binding]; other site
1229205018602	catalytic residues [active]
1229205018603	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
1229205018604	Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540
1229205018605	ligand binding site [chemical binding]; other site
1229205018606	L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288
1229205018607	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1229205018608	Walker A/P-loop; other site
1229205018609	ATP binding site [chemical binding]; other site
1229205018610	Q-loop/lid; other site
1229205018611	ABC transporter signature motif; other site
1229205018612	Walker B; other site
1229205018613	D-loop; other site
1229205018614	H-loop/switch region; other site
1229205018615	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1229205018616	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1229205018617	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1229205018618	TM-ABC transporter signature motif; other site
1229205018619	dihydroxy-acid dehydratase; Validated; Region: PRK06131
1229205018620	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
1229205018621	HIT family signature motif; other site
1229205018622	catalytic residue [active]
1229205018623	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1229205018624	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
1229205018625	putative DNA binding site [nucleotide binding]; other site
1229205018626	putative Zn2+ binding site [ion binding]; other site
1229205018627	AsnC family; Region: AsnC_trans_reg; pfam01037
1229205018628	2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012
1229205018629	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
1229205018630	dimer interface [polypeptide binding]; other site
1229205018631	TPP-binding site [chemical binding]; other site
1229205018632	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
1229205018633	integrase; Provisional; Region: PRK09692
1229205018634	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
1229205018635	active site
1229205018636	Int/Topo IB signature motif; other site
1229205018637	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1229205018638	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1229205018639	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1229205018640	G1 box; other site
1229205018641	GTP/Mg2+ binding site [chemical binding]; other site
1229205018642	Switch I region; other site
1229205018643	G2 box; other site
1229205018644	Switch II region; other site
1229205018645	G3 box; other site
1229205018646	G4 box; other site
1229205018647	G5 box; other site
1229205018648	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1229205018649	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1229205018650	sequence-specific DNA binding site [nucleotide binding]; other site
1229205018651	salt bridge; other site
1229205018652	membrane protein insertase; Provisional; Region: PRK01318
1229205018653	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
1229205018654	hypothetical protein; Validated; Region: PRK00041
1229205018655	Pirin; Region: Pirin; pfam02678
1229205018656	Haem-binding domain; Region: Haem_bd; pfam14376
1229205018657	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
1229205018658	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
1229205018659	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
1229205018660	dimerization interface [polypeptide binding]; other site
1229205018661	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
1229205018662	ATP binding site [chemical binding]; other site
1229205018663	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
1229205018664	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
1229205018665	HupF/HypC family; Region: HupF_HypC; pfam01455
1229205018666	Acylphosphatase; Region: Acylphosphatase; pfam00708
1229205018667	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
1229205018668	HypF finger; Region: zf-HYPF; pfam07503
1229205018669	HypF finger; Region: zf-HYPF; pfam07503
1229205018670	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
1229205018671	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1229205018672	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
1229205018673	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
1229205018674	coenzyme F420 hydrogenase, subunit alpha; Region: frhA; TIGR03295
1229205018675	Rubredoxin; Region: Rubredoxin; pfam00301
1229205018676	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
1229205018677	Protein of unknown function (DUF3457); Region: DUF3457; pfam11939
1229205018678	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
1229205018679	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1229205018680	HupF/HypC family; Region: HupF_HypC; pfam01455
1229205018681	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
1229205018682	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
1229205018683	putative substrate-binding site; other site
1229205018684	nickel binding site [ion binding]; other site
1229205018685	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
1229205018686	hydrogenase 1 large subunit; Provisional; Region: PRK10170
1229205018687	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
1229205018688	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
1229205018689	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
1229205018690	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
1229205018691	diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264
1229205018692	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1229205018693	inhibitor-cofactor binding pocket; inhibition site
1229205018694	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205018695	catalytic residue [active]
1229205018696	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1229205018697	Isochorismatase family; Region: Isochorismatase; pfam00857
1229205018698	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1229205018699	catalytic triad [active]
1229205018700	conserved cis-peptide bond; other site
1229205018701	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
1229205018702	dimerization interface [polypeptide binding]; other site
1229205018703	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
1229205018704	ATP binding site [chemical binding]; other site
1229205018705	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
1229205018706	Acylphosphatase; Region: Acylphosphatase; pfam00708
1229205018707	HypF finger; Region: zf-HYPF; pfam07503
1229205018708	HypF finger; Region: zf-HYPF; pfam07503
1229205018709	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
1229205018710	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015
1229205018711	FAD dependent oxidoreductase; Region: DAO; pfam01266
1229205018712	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1229205018713	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1229205018714	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205018715	dimer interface [polypeptide binding]; other site
1229205018716	conserved gate region; other site
1229205018717	putative PBP binding loops; other site
1229205018718	ABC-ATPase subunit interface; other site
1229205018719	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205018720	ABC-ATPase subunit interface; other site
1229205018721	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1229205018722	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229205018723	ABC transporter signature motif; other site
1229205018724	Walker B; other site
1229205018725	D-loop; other site
1229205018726	H-loop/switch region; other site
1229205018727	TOBE domain; Region: TOBE_2; pfam08402
1229205018728	trehalose synthase, Pseudomonas stutzeri type; Region: TreS_stutzeri; TIGR02455
1229205018729	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1229205018730	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
1229205018731	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1229205018732	NAD binding site [chemical binding]; other site
1229205018733	catalytic residues [active]
1229205018734	Homeodomain-like domain; Region: HTH_23; pfam13384
1229205018735	Winged helix-turn helix; Region: HTH_29; pfam13551
1229205018736	Homeodomain-like domain; Region: HTH_32; pfam13565
1229205018737	DDE superfamily endonuclease; Region: DDE_3; pfam13358
1229205018738	TAP-like protein; Region: Abhydrolase_4; pfam08386
1229205018739	type II secretion system protein D; Region: type_II_gspD; TIGR02517
1229205018740	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1229205018741	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1229205018742	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1229205018743	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
1229205018744	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1229205018745	Pectate lyase; Region: Pec_lyase_C; cl01593
1229205018746	Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695
1229205018747	SNF2 Helicase protein; Region: DUF3670; pfam12419
1229205018748	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
1229205018749	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1229205018750	ATP binding site [chemical binding]; other site
1229205018751	putative Mg++ binding site [ion binding]; other site
1229205018752	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1229205018753	nucleotide binding region [chemical binding]; other site
1229205018754	ATP-binding site [chemical binding]; other site
1229205018755	Uncharacterized conserved protein [Function unknown]; Region: COG4279
1229205018756	cell division protein DamX; Validated; Region: PRK10905
1229205018757	CcdB protein; Region: CcdB; cl03380
1229205018758	Post-segregation antitoxin CcdA; Region: CcdA; pfam07362
1229205018759	RES domain; Region: RES; cl02411
1229205018760	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
1229205018761	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1229205018762	NmrA (a transcriptional regulator) and triphenylmethane reductase (TMR) like proteins, subgroup 1, atypical (a) SDRs; Region: NmrA_TMR_like_1_SDR_a; cd05231
1229205018763	putative NADP binding site [chemical binding]; other site
1229205018764	short chain dehydrogenase; Validated; Region: PRK08264
1229205018765	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205018766	NAD(P) binding site [chemical binding]; other site
1229205018767	active site
1229205018768	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1229205018769	MarR family; Region: MarR_2; pfam12802
1229205018770	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
1229205018771	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
1229205018772	NAD(P) binding site [chemical binding]; other site
1229205018773	LDH/MDH dimer interface [polypeptide binding]; other site
1229205018774	substrate binding site [chemical binding]; other site
1229205018775	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1229205018776	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
1229205018777	transmembrane helices; other site
1229205018778	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
1229205018779	homodimer interface [polypeptide binding]; other site
1229205018780	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
1229205018781	active site pocket [active]
1229205018782	Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523
1229205018783	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
1229205018784	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
1229205018785	active site
1229205018786	catalytic site [active]
1229205018787	Protein of unknown function (DUF3300); Region: DUF3300; pfam11737
1229205018788	Protein of unknown function (DUF2950); Region: DUF2950; pfam11453
1229205018789	Predicted permease [General function prediction only]; Region: COG2985
1229205018790	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
1229205018791	TrkA-C domain; Region: TrkA_C; pfam02080
1229205018792	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
1229205018793	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205018794	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205018795	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1229205018796	putative effector binding pocket; other site
1229205018797	dimerization interface [polypeptide binding]; other site
1229205018798	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
1229205018799	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1229205018800	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1229205018801	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
1229205018802	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205018803	active site
1229205018804	phosphorylation site [posttranslational modification]
1229205018805	intermolecular recognition site; other site
1229205018806	dimerization interface [polypeptide binding]; other site
1229205018807	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1229205018808	DNA binding residues [nucleotide binding]
1229205018809	dimerization interface [polypeptide binding]; other site
1229205018810	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1229205018811	active site
1229205018812	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
1229205018813	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1229205018814	Ligand binding site [chemical binding]; other site
1229205018815	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1229205018816	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1229205018817	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1229205018818	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1229205018819	pyruvate carboxylase; Reviewed; Region: PRK12999
1229205018820	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1229205018821	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1229205018822	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1229205018823	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1229205018824	active site
1229205018825	catalytic residues [active]
1229205018826	metal binding site [ion binding]; metal-binding site
1229205018827	homodimer binding site [polypeptide binding]; other site
1229205018828	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1229205018829	carboxyltransferase (CT) interaction site; other site
1229205018830	biotinylation site [posttranslational modification]; other site
1229205018831	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1229205018832	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1229205018833	NAD binding site [chemical binding]; other site
1229205018834	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
1229205018835	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205018836	putative substrate translocation pore; other site
1229205018837	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205018838	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205018839	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205018840	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1229205018841	dimerization interface [polypeptide binding]; other site
1229205018842	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
1229205018843	RES domain; Region: RES; pfam08808
1229205018844	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1229205018845	Zn2+ binding site [ion binding]; other site
1229205018846	Mg2+ binding site [ion binding]; other site
1229205018847	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1229205018848	DNA-binding site [nucleotide binding]; DNA binding site
1229205018849	RNA-binding motif; other site
1229205018850	H-NS histone family; Region: Histone_HNS; pfam00816
1229205018851	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
1229205018852	Predicted transcriptional regulator [Transcription]; Region: COG4190
1229205018853	MarR family; Region: MarR_2; pfam12802
1229205018854	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229205018855	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205018856	dimer interface [polypeptide binding]; other site
1229205018857	phosphorylation site [posttranslational modification]
1229205018858	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205018859	ATP binding site [chemical binding]; other site
1229205018860	Mg2+ binding site [ion binding]; other site
1229205018861	G-X-G motif; other site
1229205018862	Response regulator receiver domain; Region: Response_reg; pfam00072
1229205018863	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205018864	active site
1229205018865	phosphorylation site [posttranslational modification]
1229205018866	intermolecular recognition site; other site
1229205018867	dimerization interface [polypeptide binding]; other site
1229205018868	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1229205018869	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1229205018870	putative dimer interface [polypeptide binding]; other site
1229205018871	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1229205018872	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1229205018873	putative dimer interface [polypeptide binding]; other site
1229205018874	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1229205018875	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1229205018876	putative dimer interface [polypeptide binding]; other site
1229205018877	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1229205018878	oligomerisation interface [polypeptide binding]; other site
1229205018879	mobile loop; other site
1229205018880	roof hairpin; other site
1229205018881	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1229205018882	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1229205018883	ring oligomerisation interface [polypeptide binding]; other site
1229205018884	ATP/Mg binding site [chemical binding]; other site
1229205018885	stacking interactions; other site
1229205018886	hinge regions; other site
1229205018887	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1229205018888	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1229205018889	nucleotide binding site [chemical binding]; other site
1229205018890	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205018891	Response regulator receiver domain; Region: Response_reg; pfam00072
1229205018892	active site
1229205018893	phosphorylation site [posttranslational modification]
1229205018894	intermolecular recognition site; other site
1229205018895	dimerization interface [polypeptide binding]; other site
1229205018896	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
1229205018897	CheB methylesterase; Region: CheB_methylest; pfam01339
1229205018898	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1229205018899	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
1229205018900	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
1229205018901	Modifier of rudimentary (Mod(r)) protein; Region: Mod_r; pfam07200
1229205018902	PAS domain; Region: PAS_10; pfam13596
1229205018903	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1229205018904	putative active site [active]
1229205018905	heme pocket [chemical binding]; other site
1229205018906	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1229205018907	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1229205018908	putative active site [active]
1229205018909	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229205018910	dimer interface [polypeptide binding]; other site
1229205018911	phosphorylation site [posttranslational modification]
1229205018912	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205018913	ATP binding site [chemical binding]; other site
1229205018914	Mg2+ binding site [ion binding]; other site
1229205018915	G-X-G motif; other site
1229205018916	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1229205018917	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205018918	active site
1229205018919	phosphorylation site [posttranslational modification]
1229205018920	intermolecular recognition site; other site
1229205018921	dimerization interface [polypeptide binding]; other site
1229205018922	Protein of unknown function (DUF1109); Region: DUF1109; pfam06532
1229205018923	RNA polymerase sigma factor; Provisional; Region: PRK12512
1229205018924	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1229205018925	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1229205018926	DNA binding residues [nucleotide binding]
1229205018927	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
1229205018928	hypothetical protein; Provisional; Region: PRK05409
1229205018929	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
1229205018930	Predicted membrane protein [Function unknown]; Region: COG2259
1229205018931	Transposase [DNA replication, recombination, and repair]; Region: COG5421
1229205018932	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205018933	Response regulator receiver domain; Region: Response_reg; pfam00072
1229205018934	active site
1229205018935	phosphorylation site [posttranslational modification]
1229205018936	intermolecular recognition site; other site
1229205018937	dimerization interface [polypeptide binding]; other site
1229205018938	Helix-turn-helix domain; Region: HTH_17; cl17695
1229205018939	PIN domain; Region: PIN_3; pfam13470
1229205018940	Homeodomain-like domain; Region: HTH_23; pfam13384
1229205018941	Winged helix-turn helix; Region: HTH_29; pfam13551
1229205018942	Homeodomain-like domain; Region: HTH_32; pfam13565
1229205018943	Integrase core domain; Region: rve; pfam00665
1229205018944	Protein of unknown function (DUF3564); Region: DUF3564; pfam12087
1229205018945	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
1229205018946	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
1229205018947	RES domain; Region: RES; cl02411
1229205018948	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487
1229205018949	putative active site [active]
1229205018950	PAS fold; Region: PAS_7; pfam12860
1229205018951	PAS domain; Region: PAS; smart00091
1229205018952	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1229205018953	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1229205018954	metal binding site [ion binding]; metal-binding site
1229205018955	active site
1229205018956	I-site; other site
1229205018957	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1229205018958	active site
1229205018959	His-Xaa-Ser system radical SAM maturase HxsC; Region: rSAM_pair_HxsC; TIGR03977
1229205018960	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1229205018961	FeS/SAM binding site; other site
1229205018962	His-Xaa-Ser system radical SAM maturase HxsB; Region: rSAM_paired_1; TIGR03978
1229205018963	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1229205018964	FeS/SAM binding site; other site
1229205018965	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1229205018966	His-Xaa-Ser system protein HsxD; Region: chp_LLNDYxLRE; TIGR03976
1229205018967	Homeodomain-like domain; Region: HTH_23; pfam13384
1229205018968	Winged helix-turn helix; Region: HTH_29; pfam13551
1229205018969	Homeodomain-like domain; Region: HTH_32; pfam13565
1229205018970	DDE superfamily endonuclease; Region: DDE_3; pfam13358
1229205018971	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
1229205018972	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
1229205018973	DDE superfamily endonuclease; Region: DDE_3; pfam13358
1229205018974	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205018975	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1229205018976	Walker A motif; other site
1229205018977	ATP binding site [chemical binding]; other site
1229205018978	Walker B motif; other site
1229205018979	H-NS histone family; Region: Histone_HNS; pfam00816
1229205018980	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
1229205018981	H-NS histone family; Region: Histone_HNS; pfam00816
1229205018982	H-NS histone family; Region: Histone_HNS; pfam00816
1229205018983	Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710
1229205018984	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1229205018985	putative DNA binding site [nucleotide binding]; other site
1229205018986	putative Zn2+ binding site [ion binding]; other site
1229205018987	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
1229205018988	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1229205018989	thiamine pyrophosphate protein; Provisional; Region: PRK08273
1229205018990	acetyacetyl-CoA reductase; Provisional; Region: PRK12938
1229205018991	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1229205018992	NAD(P) binding site [chemical binding]; other site
1229205018993	homotetramer interface [polypeptide binding]; other site
1229205018994	homodimer interface [polypeptide binding]; other site
1229205018995	active site
1229205018996	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1229205018997	active site
1229205018998	tetramer interface; other site
1229205018999	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
1229205019000	trimer interface [polypeptide binding]; other site
1229205019001	active site
1229205019002	substrate binding site [chemical binding]; other site
1229205019003	CoA binding site [chemical binding]; other site
1229205019004	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1229205019005	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1229205019006	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
1229205019007	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562
1229205019008	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
1229205019009	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
1229205019010	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1229205019011	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1229205019012	active site
1229205019013	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1229205019014	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205019015	NAD(P) binding site [chemical binding]; other site
1229205019016	active site
1229205019017	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1229205019018	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1229205019019	NAD binding site [chemical binding]; other site
1229205019020	substrate binding site [chemical binding]; other site
1229205019021	homodimer interface [polypeptide binding]; other site
1229205019022	active site
1229205019023	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
1229205019024	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1229205019025	NADP binding site [chemical binding]; other site
1229205019026	active site
1229205019027	putative substrate binding site [chemical binding]; other site
1229205019028	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
1229205019029	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1229205019030	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1229205019031	substrate binding site; other site
1229205019032	tetramer interface; other site
1229205019033	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
1229205019034	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1229205019035	Protein of unknown function (DUF2886); Region: DUF2886; pfam11102
1229205019036	Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251
1229205019037	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
1229205019038	polysaccharide export protein Wza; Provisional; Region: PRK15078
1229205019039	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
1229205019040	SLBB domain; Region: SLBB; pfam10531
1229205019041	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1229205019042	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1229205019043	active site
1229205019044	tyrosine kinase; Provisional; Region: PRK11519
1229205019045	Chain length determinant protein; Region: Wzz; pfam02706
1229205019046	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
1229205019047	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1229205019048	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
1229205019049	active site
1229205019050	catalytic residues [active]
1229205019051	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1229205019052	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK12457
1229205019053	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
1229205019054	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229205019055	active site
1229205019056	motif I; other site
1229205019057	motif II; other site
1229205019058	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
1229205019059	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
1229205019060	Ligand binding site; other site
1229205019061	oligomer interface; other site
1229205019062	KpsF/GutQ family protein; Region: kpsF; TIGR00393
1229205019063	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
1229205019064	putative active site [active]
1229205019065	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
1229205019066	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1229205019067	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1229205019068	conserved cys residue [active]
1229205019069	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205019070	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1229205019071	RES domain; Region: RES; cl02411
1229205019072	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
1229205019073	Protein of unknown function (DUF2384); Region: DUF2384; cl17718
1229205019074	transposase; Validated; Region: PRK08181
1229205019075	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205019076	Walker A motif; other site
1229205019077	ATP binding site [chemical binding]; other site
1229205019078	Helix-turn-helix domain; Region: HTH_28; pfam13518
1229205019079	Winged helix-turn helix; Region: HTH_29; pfam13551
1229205019080	Homeodomain-like domain; Region: HTH_32; pfam13565
1229205019081	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1229205019082	Integrase core domain; Region: rve; pfam00665
1229205019083	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
1229205019084	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
1229205019085	ATP binding site [chemical binding]; other site
1229205019086	Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199
1229205019087	active site
1229205019088	nucleophile elbow; other site
1229205019089	WYL domain; Region: WYL; pfam13280
1229205019090	transposase/IS protein; Provisional; Region: PRK09183
1229205019091	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205019092	Walker A motif; other site
1229205019093	ATP binding site [chemical binding]; other site
1229205019094	Walker B motif; other site
1229205019095	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1229205019096	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1229205019097	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1229205019098	Integrase core domain; Region: rve; pfam00665
1229205019099	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
1229205019100	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
1229205019101	active site
1229205019102	substrate binding site [chemical binding]; other site
1229205019103	Mg2+ binding site [ion binding]; other site
1229205019104	AAA ATPase domain; Region: AAA_16; pfam13191
1229205019105	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1229205019106	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
1229205019107	Protein of unknown function DUF262; Region: DUF262; pfam03235
1229205019108	Uncharacterized conserved protein [Function unknown]; Region: COG1479
1229205019109	Protein of unknown function DUF262; Region: DUF262; pfam03235
1229205019110	Protein of unknown function DUF262; Region: DUF262; pfam03235
1229205019111	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
1229205019112	Integrase core domain; Region: rve; pfam00665
1229205019113	transposase/IS protein; Provisional; Region: PRK09183
1229205019114	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205019115	Walker A motif; other site
1229205019116	ATP binding site [chemical binding]; other site
1229205019117	Walker B motif; other site
1229205019118	Helix-turn-helix; Region: HTH_3; pfam01381
1229205019119	Integrase core domain; Region: rve; pfam00665
1229205019120	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
1229205019121	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1229205019122	Domain of unknown function (DUF4411); Region: DUF4411; pfam14367
1229205019123	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1229205019124	Domain of unknown function (DUF955); Region: DUF955; cl01076
1229205019125	Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
1229205019126	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1229205019127	NAD(P) binding site [chemical binding]; other site
1229205019128	catalytic residues [active]
1229205019129	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1229205019130	FAD binding domain; Region: FAD_binding_4; pfam01565
1229205019131	thiamine pyrophosphate protein; Validated; Region: PRK08199
1229205019132	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1229205019133	PYR/PP interface [polypeptide binding]; other site
1229205019134	dimer interface [polypeptide binding]; other site
1229205019135	TPP binding site [chemical binding]; other site
1229205019136	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1229205019137	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
1229205019138	TPP-binding site [chemical binding]; other site
1229205019139	aspartate aminotransferase; Provisional; Region: PRK05764
1229205019140	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229205019141	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205019142	homodimer interface [polypeptide binding]; other site
1229205019143	catalytic residue [active]
1229205019144	aldolase II superfamily protein; Provisional; Region: PRK07044
1229205019145	intersubunit interface [polypeptide binding]; other site
1229205019146	active site
1229205019147	Zn2+ binding site [ion binding]; other site
1229205019148	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1229205019149	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1229205019150	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1229205019151	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1229205019152	Ligand binding site [chemical binding]; other site
1229205019153	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1229205019154	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1229205019155	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1229205019156	Walker A/P-loop; other site
1229205019157	ATP binding site [chemical binding]; other site
1229205019158	Q-loop/lid; other site
1229205019159	ABC transporter signature motif; other site
1229205019160	Walker B; other site
1229205019161	D-loop; other site
1229205019162	H-loop/switch region; other site
1229205019163	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1229205019164	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1229205019165	Walker A/P-loop; other site
1229205019166	ATP binding site [chemical binding]; other site
1229205019167	Q-loop/lid; other site
1229205019168	ABC transporter signature motif; other site
1229205019169	Walker B; other site
1229205019170	D-loop; other site
1229205019171	H-loop/switch region; other site
1229205019172	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1229205019173	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1229205019174	TM-ABC transporter signature motif; other site
1229205019175	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1229205019176	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1229205019177	TM-ABC transporter signature motif; other site
1229205019178	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
1229205019179	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
1229205019180	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
1229205019181	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
1229205019182	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1229205019183	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205019184	NAD(P) binding site [chemical binding]; other site
1229205019185	active site
1229205019186	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1229205019187	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1229205019188	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1229205019189	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205019190	NAD(P) binding site [chemical binding]; other site
1229205019191	active site
1229205019192	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
1229205019193	classical (c) SDRs; Region: SDR_c; cd05233
1229205019194	NAD(P) binding site [chemical binding]; other site
1229205019195	active site
1229205019196	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1229205019197	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205019198	DNA-binding site [nucleotide binding]; DNA binding site
1229205019199	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1229205019200	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1229205019201	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1229205019202	dimerization interface [polypeptide binding]; other site
1229205019203	ligand binding site [chemical binding]; other site
1229205019204	diaminopropionate ammonia-lyase; Provisional; Region: PRK08206
1229205019205	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1229205019206	catalytic residue [active]
1229205019207	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
1229205019208	allantoate amidohydrolase; Reviewed; Region: PRK12890
1229205019209	active site
1229205019210	metal binding site [ion binding]; metal-binding site
1229205019211	dimer interface [polypeptide binding]; other site
1229205019212	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1229205019213	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
1229205019214	AsnC family; Region: AsnC_trans_reg; pfam01037
1229205019215	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1229205019216	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1229205019217	dimerization interface [polypeptide binding]; other site
1229205019218	ligand binding site [chemical binding]; other site
1229205019219	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1229205019220	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296
1229205019221	putative NAD(P) binding site [chemical binding]; other site
1229205019222	putative substrate binding site [chemical binding]; other site
1229205019223	catalytic Zn binding site [ion binding]; other site
1229205019224	structural Zn binding site [ion binding]; other site
1229205019225	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1229205019226	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
1229205019227	Transcriptional activator [Transcription]; Region: ChrR; COG3806
1229205019228	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
1229205019229	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
1229205019230	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1229205019231	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1229205019232	classical (c) SDRs; Region: SDR_c; cd05233
1229205019233	NAD(P) binding site [chemical binding]; other site
1229205019234	active site
1229205019235	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1229205019236	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205019237	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1229205019238	dimerization interface [polypeptide binding]; other site
1229205019239	substrate binding pocket [chemical binding]; other site
1229205019240	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
1229205019241	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205019242	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205019243	dimerization interface [polypeptide binding]; other site
1229205019244	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205019245	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229205019246	putative substrate translocation pore; other site
1229205019247	StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804
1229205019248	Cupin domain; Region: Cupin_2; pfam07883
1229205019249	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1229205019250	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205019251	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1229205019252	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
1229205019253	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229205019254	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205019255	homodimer interface [polypeptide binding]; other site
1229205019256	catalytic residue [active]
1229205019257	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1229205019258	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1229205019259	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1229205019260	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1229205019261	Ligand binding site [chemical binding]; other site
1229205019262	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1229205019263	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
1229205019264	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229205019265	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205019266	homodimer interface [polypeptide binding]; other site
1229205019267	catalytic residue [active]
1229205019268	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1229205019269	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
1229205019270	aldehyde dehydrogenase family 7 member; Region: PLN02315
1229205019271	tetrameric interface [polypeptide binding]; other site
1229205019272	NAD binding site [chemical binding]; other site
1229205019273	catalytic residues [active]
1229205019274	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1229205019275	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1229205019276	dimerization interface [polypeptide binding]; other site
1229205019277	ligand binding site [chemical binding]; other site
1229205019278	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1229205019279	FAD binding domain; Region: FAD_binding_4; pfam01565
1229205019280	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1229205019281	Cysteine-rich domain; Region: CCG; pfam02754
1229205019282	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
1229205019283	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1229205019284	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205019285	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205019286	dimerization interface [polypeptide binding]; other site
1229205019287	Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324
1229205019288	short chain dehydrogenase; Provisional; Region: PRK06123
1229205019289	NADP binding site [chemical binding]; other site
1229205019290	substrate binding site [chemical binding]; other site
1229205019291	active site
1229205019292	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229205019293	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229205019294	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205019295	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229205019296	putative substrate translocation pore; other site
1229205019297	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1229205019298	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1229205019299	active site
1229205019300	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1229205019301	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1229205019302	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1229205019303	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
1229205019304	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229205019305	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205019306	homodimer interface [polypeptide binding]; other site
1229205019307	catalytic residue [active]
1229205019308	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1229205019309	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
1229205019310	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1229205019311	CoenzymeA binding site [chemical binding]; other site
1229205019312	subunit interaction site [polypeptide binding]; other site
1229205019313	PHB binding site; other site
1229205019314	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205019315	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205019316	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1229205019317	dimerization interface [polypeptide binding]; other site
1229205019318	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
1229205019319	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205019320	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229205019321	putative substrate translocation pore; other site
1229205019322	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1229205019323	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1229205019324	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1229205019325	catalytic residue [active]
1229205019326	H-NS histone family; Region: Histone_HNS; pfam00816
1229205019327	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
1229205019328	H-NS histone family; Region: Histone_HNS; pfam00816
1229205019329	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
1229205019330	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1229205019331	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1229205019332	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1229205019333	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
1229205019334	Protein of unknown function (DUF3620); Region: DUF3620; cl02233
1229205019335	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
1229205019336	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
1229205019337	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1229205019338	Cache domain; Region: Cache_2; pfam08269
1229205019339	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1229205019340	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1229205019341	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1229205019342	dimer interface [polypeptide binding]; other site
1229205019343	putative CheW interface [polypeptide binding]; other site
1229205019344	salicylate hydroxylase; Provisional; Region: PRK08163
1229205019345	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1229205019346	Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058
1229205019347	dimerization interface [polypeptide binding]; other site
1229205019348	MmoB/DmpM family; Region: MmoB_DmpM; pfam02406
1229205019349	Toluene-4-monooxygenase effector protein complex (T4mo), Rieske ferredoxin subunit; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. T4mo is a four-protein complex that catalyzes the NADH- and O2-dependent...; Region: Rieske_T4moC; cd03474
1229205019350	[2Fe-2S] cluster binding site [ion binding]; other site
1229205019351	Toluene-4-monooxygenase system protein B (TmoB); Region: TmoB; pfam06234
1229205019352	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
1229205019353	dinuclear metal binding motif [ion binding]; other site
1229205019354	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1229205019355	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1229205019356	ATP binding site [chemical binding]; other site
1229205019357	putative Mg++ binding site [ion binding]; other site
1229205019358	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1229205019359	Transposase; Region: HTH_Tnp_1; pfam01527
1229205019360	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1229205019361	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
1229205019362	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1229205019363	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
1229205019364	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1229205019365	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1229205019366	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
1229205019367	AAA domain; Region: AAA_21; pfam13304
1229205019368	translation initiation factor Sui1; Validated; Region: PRK06824
1229205019369	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
1229205019370	putative rRNA binding site [nucleotide binding]; other site
1229205019371	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
1229205019372	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
1229205019373	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
1229205019374	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
1229205019375	B-cell receptor-associated protein 31-like; Region: Bap31; cl02219
1229205019376	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
1229205019377	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1229205019378	IHF - DNA interface [nucleotide binding]; other site
1229205019379	IHF dimer interface [polypeptide binding]; other site
1229205019380	DDE domain; Region: DDE_Tnp_IS240; pfam13610
1229205019381	Integrase core domain; Region: rve; pfam00665
1229205019382	EamA-like transporter family; Region: EamA; pfam00892
1229205019383	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
1229205019384	SET domain; Region: SET; pfam00856
1229205019385	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
1229205019386	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229205019387	active site
1229205019388	motif I; other site
1229205019389	motif II; other site
1229205019390	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
1229205019391	phosphoserine aminotransferase; Provisional; Region: PRK03080
1229205019392	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1229205019393	catalytic residue [active]
1229205019394	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
1229205019395	active site
1229205019396	catalytic residues [active]
1229205019397	metal binding site [ion binding]; metal-binding site
1229205019398	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1229205019399	classical (c) SDRs; Region: SDR_c; cd05233
1229205019400	NAD(P) binding site [chemical binding]; other site
1229205019401	active site
1229205019402	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
1229205019403	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205019404	NAD(P) binding site [chemical binding]; other site
1229205019405	active site
1229205019406	putative transposase OrfB; Reviewed; Region: PHA02517
1229205019407	HTH-like domain; Region: HTH_21; pfam13276
1229205019408	Integrase core domain; Region: rve; pfam00665
1229205019409	Integrase core domain; Region: rve_3; pfam13683
1229205019410	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205019411	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205019412	trimer interface [polypeptide binding]; other site
1229205019413	eyelet of channel; other site
1229205019414	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1229205019415	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1229205019416	dimerization interface [polypeptide binding]; other site
1229205019417	ligand binding site [chemical binding]; other site
1229205019418	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1229205019419	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1229205019420	Walker A/P-loop; other site
1229205019421	ATP binding site [chemical binding]; other site
1229205019422	Q-loop/lid; other site
1229205019423	ABC transporter signature motif; other site
1229205019424	Walker B; other site
1229205019425	D-loop; other site
1229205019426	H-loop/switch region; other site
1229205019427	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1229205019428	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1229205019429	Walker A/P-loop; other site
1229205019430	ATP binding site [chemical binding]; other site
1229205019431	Q-loop/lid; other site
1229205019432	ABC transporter signature motif; other site
1229205019433	Walker B; other site
1229205019434	D-loop; other site
1229205019435	H-loop/switch region; other site
1229205019436	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1229205019437	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1229205019438	TM-ABC transporter signature motif; other site
1229205019439	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1229205019440	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1229205019441	TM-ABC transporter signature motif; other site
1229205019442	L-aspartate dehydrogenase; Provisional; Region: PRK13303
1229205019443	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1229205019444	Domain of unknown function DUF108; Region: DUF108; pfam01958
1229205019445	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
1229205019446	Cupin domain; Region: Cupin_2; pfam07883
1229205019447	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
1229205019448	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
1229205019449	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
1229205019450	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1229205019451	3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129
1229205019452	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1229205019453	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1229205019454	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205019455	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205019456	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1229205019457	putative effector binding pocket; other site
1229205019458	dimerization interface [polypeptide binding]; other site
1229205019459	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1229205019460	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1229205019461	inhibitor site; inhibition site
1229205019462	active site
1229205019463	dimer interface [polypeptide binding]; other site
1229205019464	catalytic residue [active]
1229205019465	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1229205019466	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
1229205019467	NAD(P) binding site [chemical binding]; other site
1229205019468	catalytic residues [active]
1229205019469	DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086
1229205019470	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205019471	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1229205019472	dimerization interface [polypeptide binding]; other site
1229205019473	substrate binding pocket [chemical binding]; other site
1229205019474	D-serine dehydratase; Provisional; Region: PRK02991
1229205019475	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
1229205019476	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1229205019477	catalytic residue [active]
1229205019478	Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952
1229205019479	Predicted nucleotidyltransferase [General function prediction    only]; Region: COG4849
1229205019480	ACT domain; Region: ACT_3; pfam10000
1229205019481	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602
1229205019482	Family description; Region: ACT_7; pfam13840
1229205019483	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1229205019484	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229205019485	non-specific DNA binding site [nucleotide binding]; other site
1229205019486	salt bridge; other site
1229205019487	sequence-specific DNA binding site [nucleotide binding]; other site
1229205019488	Protein of unknown function (DUF3577); Region: DUF3577; pfam12101
1229205019489	Antirestriction protein; Region: Antirestrict; pfam03230
1229205019490	Protein of unknown function (DUF3275); Region: DUF3275; pfam11679
1229205019491	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1229205019492	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1229205019493	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1229205019494	ATP binding site [chemical binding]; other site
1229205019495	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
1229205019496	Protein of unknown function (DUF3085); Region: DUF3085; pfam11284
1229205019497	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
1229205019498	active site
1229205019499	catalytic triad [active]
1229205019500	dimer interface [polypeptide binding]; other site
1229205019501	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
1229205019502	Integrase core domain; Region: rve_3; cl15866
1229205019503	D-lactate dehydrogenase; Provisional; Region: PRK11183
1229205019504	FAD binding domain; Region: FAD_binding_4; pfam01565
1229205019505	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
1229205019506	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1229205019507	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1229205019508	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205019509	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1229205019510	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1229205019511	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1229205019512	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
1229205019513	dimer interface [polypeptide binding]; other site
1229205019514	active site
1229205019515	metal binding site [ion binding]; metal-binding site
1229205019516	glutathione binding site [chemical binding]; other site
1229205019517	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
1229205019518	classical (c) SDRs; Region: SDR_c; cd05233
1229205019519	NAD(P) binding site [chemical binding]; other site
1229205019520	active site
1229205019521	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
1229205019522	classical (c) SDRs; Region: SDR_c; cd05233
1229205019523	NAD(P) binding site [chemical binding]; other site
1229205019524	active site
1229205019525	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1229205019526	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
1229205019527	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205019528	NAD(P) binding site [chemical binding]; other site
1229205019529	short chain dehydrogenase; Validated; Region: PRK07069
1229205019530	active site
1229205019531	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1229205019532	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1229205019533	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1229205019534	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1229205019535	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1229205019536	IHF dimer interface [polypeptide binding]; other site
1229205019537	IHF - DNA interface [nucleotide binding]; other site
1229205019538	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
1229205019539	generic binding surface I; other site
1229205019540	generic binding surface II; other site
1229205019541	Domain of unknown function (DUF1845); Region: DUF1845; cl07481
1229205019542	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1229205019543	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1229205019544	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1229205019545	Magnesium ion binding site [ion binding]; other site
1229205019546	Helix-turn-helix domain; Region: HTH_17; pfam12728
1229205019547	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1229205019548	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229205019549	non-specific DNA binding site [nucleotide binding]; other site
1229205019550	salt bridge; other site
1229205019551	sequence-specific DNA binding site [nucleotide binding]; other site
1229205019552	chromosome replication initiation inhibitor protein; Provisional; Region: PRK13348
1229205019553	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205019554	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205019555	dimerization interface [polypeptide binding]; other site
1229205019556	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205019557	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205019558	dimerization interface [polypeptide binding]; other site
1229205019559	ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995
1229205019560	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229205019561	substrate binding pocket [chemical binding]; other site
1229205019562	membrane-bound complex binding site; other site
1229205019563	hinge residues; other site
1229205019564	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
1229205019565	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1229205019566	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205019567	dimer interface [polypeptide binding]; other site
1229205019568	conserved gate region; other site
1229205019569	putative PBP binding loops; other site
1229205019570	ABC-ATPase subunit interface; other site
1229205019571	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1229205019572	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1229205019573	Walker A/P-loop; other site
1229205019574	ATP binding site [chemical binding]; other site
1229205019575	Q-loop/lid; other site
1229205019576	ABC transporter signature motif; other site
1229205019577	Walker B; other site
1229205019578	D-loop; other site
1229205019579	H-loop/switch region; other site
1229205019580	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1229205019581	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205019582	dimer interface [polypeptide binding]; other site
1229205019583	conserved gate region; other site
1229205019584	putative PBP binding loops; other site
1229205019585	ABC-ATPase subunit interface; other site
1229205019586	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205019587	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205019588	trimer interface [polypeptide binding]; other site
1229205019589	eyelet of channel; other site
1229205019590	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
1229205019591	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1229205019592	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1229205019593	catalytic residue [active]
1229205019594	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
1229205019595	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205019596	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205019597	dimerization interface [polypeptide binding]; other site
1229205019598	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1229205019599	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1229205019600	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
1229205019601	active site
1229205019602	ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994
1229205019603	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252
1229205019604	putative active site [active]
1229205019605	Zn binding site [ion binding]; other site
1229205019606	D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409
1229205019607	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1229205019608	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1229205019609	Domain of unknown function (DUF336); Region: DUF336; cl01249
1229205019610	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1229205019611	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1229205019612	substrate-cofactor binding pocket; other site
1229205019613	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205019614	catalytic residue [active]
1229205019615	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
1229205019616	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1229205019617	NAD(P) binding site [chemical binding]; other site
1229205019618	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205019619	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205019620	chromosome replication initiation inhibitor protein; Provisional; Region: PRK13348
1229205019621	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205019622	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205019623	dimerization interface [polypeptide binding]; other site
1229205019624	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1229205019625	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1229205019626	NAD(P) binding site [chemical binding]; other site
1229205019627	catalytic residues [active]
1229205019628	3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129
1229205019629	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1229205019630	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1229205019631	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1229205019632	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205019633	NAD(P) binding site [chemical binding]; other site
1229205019634	active site
1229205019635	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205019636	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
1229205019637	NAD(P) binding site [chemical binding]; other site
1229205019638	active site
1229205019639	SnoaL-like domain; Region: SnoaL_2; pfam12680
1229205019640	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1229205019641	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1229205019642	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1229205019643	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1229205019644	TM-ABC transporter signature motif; other site
1229205019645	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1229205019646	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1229205019647	Walker A/P-loop; other site
1229205019648	ATP binding site [chemical binding]; other site
1229205019649	Q-loop/lid; other site
1229205019650	ABC transporter signature motif; other site
1229205019651	Walker B; other site
1229205019652	D-loop; other site
1229205019653	H-loop/switch region; other site
1229205019654	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1229205019655	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
1229205019656	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1229205019657	ligand binding site [chemical binding]; other site
1229205019658	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
1229205019659	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229205019660	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1229205019661	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
1229205019662	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1229205019663	E3 interaction surface; other site
1229205019664	lipoyl attachment site [posttranslational modification]; other site
1229205019665	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1229205019666	catalytic site [active]
1229205019667	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1229205019668	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1229205019669	alpha subunit interface [polypeptide binding]; other site
1229205019670	TPP binding site [chemical binding]; other site
1229205019671	heterodimer interface [polypeptide binding]; other site
1229205019672	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1229205019673	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
1229205019674	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1229205019675	tetramer interface [polypeptide binding]; other site
1229205019676	TPP-binding site [chemical binding]; other site
1229205019677	heterodimer interface [polypeptide binding]; other site
1229205019678	phosphorylation loop region [posttranslational modification]
1229205019679	Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199
1229205019680	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1229205019681	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205019682	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205019683	trimer interface [polypeptide binding]; other site
1229205019684	eyelet of channel; other site
1229205019685	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1229205019686	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
1229205019687	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1229205019688	ligand binding site [chemical binding]; other site
1229205019689	acetaldehyde dehydrogenase; Validated; Region: PRK08300
1229205019690	Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488
1229205019691	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
1229205019692	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
1229205019693	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
1229205019694	active site
1229205019695	catalytic residues [active]
1229205019696	metal binding site [ion binding]; metal-binding site
1229205019697	DmpG-like communication domain; Region: DmpG_comm; pfam07836
1229205019698	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205019699	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1229205019700	NAD(P) binding site [chemical binding]; other site
1229205019701	active site
1229205019702	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1229205019703	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
1229205019704	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1229205019705	PYR/PP interface [polypeptide binding]; other site
1229205019706	dimer interface [polypeptide binding]; other site
1229205019707	TPP binding site [chemical binding]; other site
1229205019708	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1229205019709	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
1229205019710	TPP-binding site [chemical binding]; other site
1229205019711	integrase; Provisional; Region: PRK09692
1229205019712	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
1229205019713	active site
1229205019714	Int/Topo IB signature motif; other site
1229205019715	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
1229205019716	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
1229205019717	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1229205019718	Antirestriction protein; Region: Antirestrict; pfam03230
1229205019719	Domain of unknown function (DUF932); Region: DUF932; pfam06067
1229205019720	Protein of unknown function (DUF3717); Region: DUF3717; pfam12512
1229205019721	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1229205019722	non-specific DNA binding site [nucleotide binding]; other site
1229205019723	salt bridge; other site
1229205019724	sequence-specific DNA binding site [nucleotide binding]; other site
1229205019725	Argonaute siRNA chaperone (ARC) complex subunit Arb1; Region: Arb1; pfam09692
1229205019726	Initiator Replication protein; Region: Rep_3; pfam01051
1229205019727	cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371
1229205019728	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1229205019729	P-loop; other site
1229205019730	Magnesium ion binding site [ion binding]; other site
1229205019731	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1229205019732	Magnesium ion binding site [ion binding]; other site
1229205019733	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1229205019734	ParB-like nuclease domain; Region: ParB; smart00470
1229205019735	Protein of unknown function (DUF1778); Region: DUF1778; pfam08681
1229205019736	RNase II stability modulator; Provisional; Region: PRK10060
1229205019737	PAS domain; Region: PAS_9; pfam13426
1229205019738	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1229205019739	putative active site [active]
1229205019740	heme pocket [chemical binding]; other site
1229205019741	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1229205019742	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229205019743	non-specific DNA binding site [nucleotide binding]; other site
1229205019744	salt bridge; other site
1229205019745	sequence-specific DNA binding site [nucleotide binding]; other site
1229205019746	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1229205019747	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1229205019748	catalytic residue [active]
1229205019749	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
1229205019750	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
1229205019751	Type IV secretion system proteins; Region: T4SS; pfam07996
1229205019752	P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791
1229205019753	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
1229205019754	Cag pathogenicity island protein Cag12; Region: Cag12; pfam13117
1229205019755	VirB8 protein; Region: VirB8; pfam04335
1229205019756	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
1229205019757	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
1229205019758	VirB7 interaction site; other site
1229205019759	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
1229205019760	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
1229205019761	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1229205019762	Walker A motif; other site
1229205019763	hexamer interface [polypeptide binding]; other site
1229205019764	ATP binding site [chemical binding]; other site
1229205019765	Walker B motif; other site
1229205019766	conjugal transfer coupling protein TraG; Provisional; Region: PRK13876
1229205019767	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
1229205019768	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1229205019769	Walker A motif; other site
1229205019770	ATP binding site [chemical binding]; other site
1229205019771	Walker B motif; other site
1229205019772	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
1229205019773	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
1229205019774	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1229205019775	putative DNA binding site [nucleotide binding]; other site
1229205019776	putative Zn2+ binding site [ion binding]; other site
1229205019777	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
1229205019778	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1229205019779	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205019780	DNA-binding site [nucleotide binding]; DNA binding site
1229205019781	UTRA domain; Region: UTRA; pfam07702
1229205019782	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229205019783	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1229205019784	substrate binding pocket [chemical binding]; other site
1229205019785	membrane-bound complex binding site; other site
1229205019786	hinge residues; other site
1229205019787	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1229205019788	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205019789	dimer interface [polypeptide binding]; other site
1229205019790	conserved gate region; other site
1229205019791	putative PBP binding loops; other site
1229205019792	ABC-ATPase subunit interface; other site
1229205019793	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1229205019794	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1229205019795	Walker A/P-loop; other site
1229205019796	ATP binding site [chemical binding]; other site
1229205019797	Q-loop/lid; other site
1229205019798	ABC transporter signature motif; other site
1229205019799	Walker B; other site
1229205019800	D-loop; other site
1229205019801	H-loop/switch region; other site
1229205019802	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
1229205019803	classical (c) SDRs; Region: SDR_c; cd05233
1229205019804	NAD(P) binding site [chemical binding]; other site
1229205019805	active site
1229205019806	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205019807	transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481
1229205019808	DNA-binding site [nucleotide binding]; DNA binding site
1229205019809	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229205019810	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205019811	homodimer interface [polypeptide binding]; other site
1229205019812	catalytic residue [active]
1229205019813	Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874
1229205019814	Amidinotransferase; Region: Amidinotransf; pfam02274
1229205019815	ornithine cyclodeaminase; Validated; Region: PRK07589
1229205019816	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
1229205019817	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1229205019818	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1229205019819	putative DNA binding site [nucleotide binding]; other site
1229205019820	putative Zn2+ binding site [ion binding]; other site
1229205019821	AsnC family; Region: AsnC_trans_reg; pfam01037
1229205019822	histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437
1229205019823	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229205019824	substrate binding pocket [chemical binding]; other site
1229205019825	membrane-bound complex binding site; other site
1229205019826	hinge residues; other site
1229205019827	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
1229205019828	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205019829	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229205019830	dimerization interface [polypeptide binding]; other site
1229205019831	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
1229205019832	homotrimer interaction site [polypeptide binding]; other site
1229205019833	putative active site [active]
1229205019834	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1229205019835	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1229205019836	gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847
1229205019837	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
1229205019838	NAD(P) binding site [chemical binding]; other site
1229205019839	catalytic residues [active]
1229205019840	allantoate amidohydrolase; Reviewed; Region: PRK12893
1229205019841	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
1229205019842	active site
1229205019843	metal binding site [ion binding]; metal-binding site
1229205019844	dimer interface [polypeptide binding]; other site
1229205019845	thiamine pyrophosphate protein; Validated; Region: PRK08199
1229205019846	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1229205019847	PYR/PP interface [polypeptide binding]; other site
1229205019848	dimer interface [polypeptide binding]; other site
1229205019849	TPP binding site [chemical binding]; other site
1229205019850	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1229205019851	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
1229205019852	TPP-binding site [chemical binding]; other site
1229205019853	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
1229205019854	homotrimer interaction site [polypeptide binding]; other site
1229205019855	putative active site [active]
1229205019856	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1229205019857	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
1229205019858	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229205019859	substrate binding pocket [chemical binding]; other site
1229205019860	membrane-bound complex binding site; other site
1229205019861	hinge residues; other site
1229205019862	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
1229205019863	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229205019864	Walker A/P-loop; other site
1229205019865	ATP binding site [chemical binding]; other site
1229205019866	Q-loop/lid; other site
1229205019867	ABC transporter signature motif; other site
1229205019868	Walker B; other site
1229205019869	D-loop; other site
1229205019870	H-loop/switch region; other site
1229205019871	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205019872	dimer interface [polypeptide binding]; other site
1229205019873	conserved gate region; other site
1229205019874	putative PBP binding loops; other site
1229205019875	ABC-ATPase subunit interface; other site
1229205019876	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1229205019877	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205019878	dimer interface [polypeptide binding]; other site
1229205019879	conserved gate region; other site
1229205019880	putative PBP binding loops; other site
1229205019881	ABC-ATPase subunit interface; other site
1229205019882	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
1229205019883	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229205019884	AAA ATPase domain; Region: AAA_16; pfam13191
1229205019885	Walker A motif; other site
1229205019886	ATP binding site [chemical binding]; other site
1229205019887	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1229205019888	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205019889	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1229205019890	dimerization interface [polypeptide binding]; other site
1229205019891	substrate binding pocket [chemical binding]; other site
1229205019892	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229205019893	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
1229205019894	Walker A/P-loop; other site
1229205019895	ATP binding site [chemical binding]; other site
1229205019896	Q-loop/lid; other site
1229205019897	ABC transporter signature motif; other site
1229205019898	Walker B; other site
1229205019899	D-loop; other site
1229205019900	H-loop/switch region; other site
1229205019901	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1229205019902	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1229205019903	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1229205019904	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205019905	dimer interface [polypeptide binding]; other site
1229205019906	conserved gate region; other site
1229205019907	putative PBP binding loops; other site
1229205019908	ABC-ATPase subunit interface; other site
1229205019909	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205019910	dimer interface [polypeptide binding]; other site
1229205019911	conserved gate region; other site
1229205019912	putative PBP binding loops; other site
1229205019913	ABC-ATPase subunit interface; other site
1229205019914	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1229205019915	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1229205019916	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
1229205019917	active site
1229205019918	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
1229205019919	Peptidase C26; Region: Peptidase_C26; pfam07722
1229205019920	catalytic triad [active]
1229205019921	hypothetical protein; Provisional; Region: PRK07475
1229205019922	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229205019923	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229205019924	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229205019925	short chain dehydrogenase; Provisional; Region: PRK06123
1229205019926	NAD(P) binding site [chemical binding]; other site
1229205019927	active site
1229205019928	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205019929	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205019930	trimer interface [polypeptide binding]; other site
1229205019931	eyelet of channel; other site
1229205019932	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229205019933	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1229205019934	substrate binding pocket [chemical binding]; other site
1229205019935	membrane-bound complex binding site; other site
1229205019936	hinge residues; other site
1229205019937	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
1229205019938	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
1229205019939	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
1229205019940	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1229205019941	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205019942	dimer interface [polypeptide binding]; other site
1229205019943	conserved gate region; other site
1229205019944	putative PBP binding loops; other site
1229205019945	ABC-ATPase subunit interface; other site
1229205019946	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
1229205019947	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1229205019948	Walker A/P-loop; other site
1229205019949	ATP binding site [chemical binding]; other site
1229205019950	Q-loop/lid; other site
1229205019951	ABC transporter signature motif; other site
1229205019952	Walker B; other site
1229205019953	D-loop; other site
1229205019954	H-loop/switch region; other site
1229205019955	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
1229205019956	active sites [active]
1229205019957	tetramer interface [polypeptide binding]; other site
1229205019958	urocanate hydratase; Provisional; Region: PRK05414
1229205019959	HutD; Region: HutD; pfam05962
1229205019960	imidazolonepropionase; Validated; Region: PRK09356
1229205019961	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
1229205019962	active site
1229205019963	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
1229205019964	Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313
1229205019965	active site
1229205019966	N-formylglutamate amidohydrolase; Region: FGase; cl01522
1229205019967	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1229205019968	Tar ligand binding domain homologue; Region: TarH; pfam02203
1229205019969	dimer interface [polypeptide binding]; other site
1229205019970	ligand binding site [chemical binding]; other site
1229205019971	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1229205019972	dimerization interface [polypeptide binding]; other site
1229205019973	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1229205019974	dimer interface [polypeptide binding]; other site
1229205019975	putative CheW interface [polypeptide binding]; other site
1229205019976	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205019977	DNA-binding site [nucleotide binding]; DNA binding site
1229205019978	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1229205019979	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229205019980	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1229205019981	substrate binding pocket [chemical binding]; other site
1229205019982	membrane-bound complex binding site; other site
1229205019983	hinge residues; other site
1229205019984	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205019985	dimer interface [polypeptide binding]; other site
1229205019986	conserved gate region; other site
1229205019987	putative PBP binding loops; other site
1229205019988	ABC-ATPase subunit interface; other site
1229205019989	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1229205019990	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205019991	dimer interface [polypeptide binding]; other site
1229205019992	conserved gate region; other site
1229205019993	putative PBP binding loops; other site
1229205019994	ABC-ATPase subunit interface; other site
1229205019995	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1229205019996	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1229205019997	Walker A/P-loop; other site
1229205019998	ATP binding site [chemical binding]; other site
1229205019999	Q-loop/lid; other site
1229205020000	ABC transporter signature motif; other site
1229205020001	Walker B; other site
1229205020002	D-loop; other site
1229205020003	H-loop/switch region; other site
1229205020004	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
1229205020005	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1229205020006	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205020007	Walker A motif; other site
1229205020008	ATP binding site [chemical binding]; other site
1229205020009	Walker B motif; other site
1229205020010	ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583
1229205020011	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
1229205020012	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295
1229205020013	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1229205020014	motif 1; other site
1229205020015	dimer interface [polypeptide binding]; other site
1229205020016	motif 2; other site
1229205020017	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1229205020018	active site
1229205020019	motif 3; other site
1229205020020	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205020021	putative transporter; Provisional; Region: PRK10504
1229205020022	putative substrate translocation pore; other site
1229205020023	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
1229205020024	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229205020025	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205020026	homodimer interface [polypeptide binding]; other site
1229205020027	catalytic residue [active]
1229205020028	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1229205020029	IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193
1229205020030	Int/Topo IB signature motif; other site
1229205020031	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
1229205020032	Putative transposase; Region: Y2_Tnp; pfam04986
1229205020033	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1229205020034	Integrase core domain; Region: rve; pfam00665
1229205020035	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
1229205020036	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
1229205020037	CdtB, the catalytic DNase I-like subunit of cytolethal distending toxin (CDT) protein; Region: CdtB; cd09081
1229205020038	putative catalytic site [active]
1229205020039	CdtC interface [polypeptide binding]; other site
1229205020040	heterotrimer interface [polypeptide binding]; other site
1229205020041	CdtA interface [polypeptide binding]; other site
1229205020042	putative metal binding site [ion binding]; other site
1229205020043	putative phosphate binding site [ion binding]; other site
1229205020044	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
1229205020045	Nitrogen fixation protein NifW; Region: NifW; pfam03206
1229205020046	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1229205020047	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205020048	active site
1229205020049	phosphorylation site [posttranslational modification]
1229205020050	intermolecular recognition site; other site
1229205020051	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1229205020052	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1229205020053	putative active site [active]
1229205020054	putative NTP binding site [chemical binding]; other site
1229205020055	putative nucleic acid binding site [nucleotide binding]; other site
1229205020056	Transposase domain (DUF772); Region: DUF772; pfam05598
1229205020057	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1229205020058	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1229205020059	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1229205020060	non-specific DNA interactions [nucleotide binding]; other site
1229205020061	DNA binding site [nucleotide binding]
1229205020062	sequence specific DNA binding site [nucleotide binding]; other site
1229205020063	putative cAMP binding site [chemical binding]; other site
1229205020064	Bacterial transcriptional regulator; Region: IclR; pfam01614
1229205020065	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
1229205020066	active site
1229205020067	catalytic residues [active]
1229205020068	metal binding site [ion binding]; metal-binding site
1229205020069	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1229205020070	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1229205020071	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1229205020072	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229205020073	putative substrate translocation pore; other site
1229205020074	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
1229205020075	Amidohydrolase; Region: Amidohydro_2; pfam04909
1229205020076	Hemerythrin-like domain; Region: Hr-like; cd12108
1229205020077	Fe binding site [ion binding]; other site
1229205020078	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
1229205020079	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1229205020080	FeS/SAM binding site; other site
1229205020081	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1229205020082	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1229205020083	DNA binding site [nucleotide binding]
1229205020084	domain linker motif; other site
1229205020085	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
1229205020086	ligand binding site [chemical binding]; other site
1229205020087	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
1229205020088	multidrug efflux protein; Reviewed; Region: PRK09579
1229205020089	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1229205020090	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1229205020091	HlyD family secretion protein; Region: HlyD_3; pfam13437
1229205020092	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1229205020093	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
1229205020094	ligand-binding site [chemical binding]; other site
1229205020095	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
1229205020096	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
1229205020097	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229205020098	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1229205020099	S-adenosylmethionine binding site [chemical binding]; other site
1229205020100	Nodulation protein A (NodA); Region: NodA; pfam02474
1229205020101	Stf0 sulphotransferase; Region: Sulphotransf; cl01835
1229205020102	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1229205020103	ATP-binding ABC transporter family nodulation protein NodI; Region: nodI; TIGR01288
1229205020104	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
1229205020105	Walker A/P-loop; other site
1229205020106	ATP binding site [chemical binding]; other site
1229205020107	Q-loop/lid; other site
1229205020108	ABC transporter signature motif; other site
1229205020109	Walker B; other site
1229205020110	D-loop; other site
1229205020111	H-loop/switch region; other site
1229205020112	chitooligosaccharide synthase NodC; Region: nodulat_NodC; TIGR04242
1229205020113	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1229205020114	DXD motif; other site
1229205020115	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1229205020116	chitooligosaccharide deacetylase NodB; Region: nodulat_NodB; TIGR04243
1229205020117	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205020118	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205020119	The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462
1229205020120	putative substrate binding pocket [chemical binding]; other site
1229205020121	putative dimerization interface [polypeptide binding]; other site
1229205020122	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
1229205020123	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205020124	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205020125	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1229205020126	dimerization interface [polypeptide binding]; other site
1229205020127	Nif-specific regulatory protein; Region: nifA; TIGR01817
1229205020128	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1229205020129	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205020130	Walker A motif; other site
1229205020131	ATP binding site [chemical binding]; other site
1229205020132	Walker B motif; other site
1229205020133	arginine finger; other site
1229205020134	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1229205020135	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
1229205020136	nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478
1229205020137	Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966
1229205020138	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
1229205020139	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
1229205020140	Rop-like; Region: Rop-like; pfam05082
1229205020141	ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936
1229205020142	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1229205020143	NifQ; Region: NifQ; pfam04891
1229205020144	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
1229205020145	oxidoreductase; Provisional; Region: PRK10015
1229205020146	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1229205020147	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1229205020148	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1229205020149	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1229205020150	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1229205020151	Ligand binding site [chemical binding]; other site
1229205020152	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1229205020153	Nitrogen fixation protein NifW; Region: NifW; pfam03206
1229205020154	homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660
1229205020155	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
1229205020156	active site
1229205020157	catalytic residues [active]
1229205020158	metal binding site [ion binding]; metal-binding site
1229205020159	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
1229205020160	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1229205020161	FeS/SAM binding site; other site
1229205020162	NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852
1229205020163	archaeoflavoprotein, MJ0208 family; Region: flavo_MJ0208; TIGR02700
1229205020164	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
1229205020165	NifZ domain; Region: NifZ; pfam04319
1229205020166	NifZ domain; Region: NifZ; pfam04319
1229205020167	NifT/FixU protein; Region: NifT; pfam06988
1229205020168	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1229205020169	Winged helix-turn helix; Region: HTH_29; pfam13551
1229205020170	Homeodomain-like domain; Region: HTH_32; pfam13565
1229205020171	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723
1229205020172	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1229205020173	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1229205020174	nitrogenase reductase; Reviewed; Region: nifH; PRK13234
1229205020175	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
1229205020176	Nucleotide-binding sites [chemical binding]; other site
1229205020177	Walker A motif; other site
1229205020178	Switch I region of nucleotide binding site; other site
1229205020179	Fe4S4 binding sites [ion binding]; other site
1229205020180	Switch II region of nucleotide binding site; other site
1229205020181	Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710
1229205020182	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
1229205020183	MoFe protein alpha/beta subunit interactions; other site
1229205020184	Alpha subunit P cluster binding residues; other site
1229205020185	FeMoco binding residues [chemical binding]; other site
1229205020186	MoFe protein alpha subunit/Fe protein contacts; other site
1229205020187	MoFe protein dimer/ dimer interactions; other site
1229205020188	nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286
1229205020189	Domain of unknown function (DUF3364); Region: DUF3364; pfam11844
1229205020190	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
1229205020191	MoFe protein beta/alpha subunit interactions; other site
1229205020192	Beta subunit P cluster binding residues; other site
1229205020193	MoFe protein beta subunit/Fe protein contacts; other site
1229205020194	MoFe protein dimer/ dimer interactions; other site
1229205020195	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
1229205020196	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1229205020197	substrate binding site [chemical binding]; other site
1229205020198	activation loop (A-loop); other site
1229205020199	AAA ATPase domain; Region: AAA_16; pfam13191
1229205020200	Predicted ATPase [General function prediction only]; Region: COG3899
1229205020201	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1229205020202	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1229205020203	PAS domain S-box; Region: sensory_box; TIGR00229
1229205020204	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1229205020205	putative active site [active]
1229205020206	heme pocket [chemical binding]; other site
1229205020207	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1229205020208	Histidine kinase; Region: HisKA_3; pfam07730
1229205020209	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205020210	ATP binding site [chemical binding]; other site
1229205020211	Mg2+ binding site [ion binding]; other site
1229205020212	G-X-G motif; other site
1229205020213	carbon starvation protein A; Provisional; Region: PRK15015
1229205020214	Carbon starvation protein CstA; Region: CstA; pfam02554
1229205020215	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
1229205020216	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
1229205020217	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
1229205020218	Histidine kinase; Region: HisKA_3; pfam07730
1229205020219	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229205020220	ATP binding site [chemical binding]; other site
1229205020221	Mg2+ binding site [ion binding]; other site
1229205020222	G-X-G motif; other site
1229205020223	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1229205020224	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205020225	active site
1229205020226	phosphorylation site [posttranslational modification]
1229205020227	intermolecular recognition site; other site
1229205020228	dimerization interface [polypeptide binding]; other site
1229205020229	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1229205020230	DNA binding residues [nucleotide binding]
1229205020231	dimerization interface [polypeptide binding]; other site
1229205020232	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1229205020233	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229205020234	active site
1229205020235	phosphorylation site [posttranslational modification]
1229205020236	intermolecular recognition site; other site
1229205020237	dimerization interface [polypeptide binding]; other site
1229205020238	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1229205020239	DNA binding residues [nucleotide binding]
1229205020240	dimerization interface [polypeptide binding]; other site
1229205020241	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1229205020242	Cytochrome P450; Region: p450; cl12078
1229205020243	Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039
1229205020244	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1229205020245	indole acetimide hydrolase; Validated; Region: PRK07488
1229205020246	Amidase; Region: Amidase; pfam01425
1229205020247	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1229205020248	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
1229205020249	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
1229205020250	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
1229205020251	Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302
1229205020252	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
1229205020253	NifZ domain; Region: NifZ; pfam04319
1229205020254	NifT/FixU protein; Region: NifT; pfam06988
1229205020255	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1229205020256	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1229205020257	catalytic residue [active]
1229205020258	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
1229205020259	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1229205020260	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1229205020261	catalytic residue [active]
1229205020262	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
1229205020263	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1229205020264	putative di-iron ligands [ion binding]; other site
1229205020265	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
1229205020266	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
1229205020267	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
1229205020268	catalytic triad [active]
1229205020269	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1229205020270	homoserine O-succinyltransferase; Provisional; Region: PRK05368
1229205020271	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
1229205020272	proposed active site lysine [active]
1229205020273	conserved cys residue [active]
1229205020274	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1229205020275	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1229205020276	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1229205020277	transposase/IS protein; Provisional; Region: PRK09183
1229205020278	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229205020279	Walker A motif; other site
1229205020280	ATP binding site [chemical binding]; other site
1229205020281	Walker B motif; other site
1229205020282	arginine finger; other site
1229205020283	Winged helix-turn helix; Region: HTH_29; pfam13551
1229205020284	Winged helix-turn helix; Region: HTH_33; pfam13592
1229205020285	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205020286	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205020287	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1229205020288	dimerization interface [polypeptide binding]; other site
1229205020289	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
1229205020290	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1229205020291	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229205020292	DNA-binding site [nucleotide binding]; DNA binding site
1229205020293	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1229205020294	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1229205020295	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
1229205020296	active site
1229205020297	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1229205020298	Amidase; Region: Amidase; pfam01425
1229205020299	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1229205020300	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1229205020301	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
1229205020302	Walker A/P-loop; other site
1229205020303	ATP binding site [chemical binding]; other site
1229205020304	Q-loop/lid; other site
1229205020305	ABC transporter signature motif; other site
1229205020306	Walker B; other site
1229205020307	D-loop; other site
1229205020308	H-loop/switch region; other site
1229205020309	TOBE domain; Region: TOBE_2; pfam08402
1229205020310	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205020311	dimer interface [polypeptide binding]; other site
1229205020312	conserved gate region; other site
1229205020313	putative PBP binding loops; other site
1229205020314	ABC-ATPase subunit interface; other site
1229205020315	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1229205020316	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229205020317	dimer interface [polypeptide binding]; other site
1229205020318	conserved gate region; other site
1229205020319	putative PBP binding loops; other site
1229205020320	ABC-ATPase subunit interface; other site
1229205020321	N-formylglutamate amidohydrolase; Region: FGase; cl01522
1229205020322	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1229205020323	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1229205020324	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1229205020325	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1229205020326	Ligand binding site [chemical binding]; other site
1229205020327	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1229205020328	HutD; Region: HutD; cl01532
1229205020329	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1229205020330	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1229205020331	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1229205020332	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
1229205020333	nitrogenase reductase; Reviewed; Region: nifH; PRK13234
1229205020334	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
1229205020335	Nucleotide-binding sites [chemical binding]; other site
1229205020336	Walker A motif; other site
1229205020337	Switch I region of nucleotide binding site; other site
1229205020338	Fe4S4 binding sites [ion binding]; other site
1229205020339	Switch II region of nucleotide binding site; other site
1229205020340	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229205020341	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229205020342	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
1229205020343	EamA-like transporter family; Region: EamA; pfam00892
1229205020344	Protein of unknown function (DUF3757); Region: DUF3757; pfam12582
1229205020345	chorismate mutase; Provisional; Region: PRK09269
1229205020346	Chorismate mutase type II; Region: CM_2; cl00693
1229205020347	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1229205020348	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
1229205020349	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1229205020350	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1229205020351	trimer interface [polypeptide binding]; other site
1229205020352	eyelet of channel; other site
1229205020353	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
1229205020354	Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449
1229205020355	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229205020356	catalytic residue [active]