-- dump date 20140619_011304 -- class Genbank::misc_feature -- table misc_feature_note -- id note 568815000001 replication initiation protein RepC; Provisional; Region: PRK13824 568815000002 Replication protein C N-terminal domain; Region: RP-C; pfam03428 568815000003 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 568815000004 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 568815000005 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 568815000006 substrate binding site [chemical binding]; other site 568815000007 dimer interface [polypeptide binding]; other site 568815000008 ATP binding site [chemical binding]; other site 568815000009 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 568815000010 active site 568815000011 tetramer interface [polypeptide binding]; other site 568815000012 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 568815000013 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 568815000014 TM-ABC transporter signature motif; other site 568815000015 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568815000016 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 568815000017 TM-ABC transporter signature motif; other site 568815000018 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 568815000019 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 568815000020 Walker A/P-loop; other site 568815000021 ATP binding site [chemical binding]; other site 568815000022 Q-loop/lid; other site 568815000023 ABC transporter signature motif; other site 568815000024 Walker B; other site 568815000025 D-loop; other site 568815000026 H-loop/switch region; other site 568815000027 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 568815000028 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 568815000029 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 568815000030 ligand binding site [chemical binding]; other site 568815000031 Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5664 568815000032 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 568815000033 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 568815000034 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 568815000035 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 568815000036 putative NAD(P) binding site [chemical binding]; other site 568815000037 active site 568815000038 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 568815000039 hydrophobic substrate binding pocket; other site 568815000040 Isochorismatase family; Region: Isochorismatase; pfam00857 568815000041 active site 568815000042 conserved cis-peptide bond; other site 568815000043 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 568815000044 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 568815000045 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 568815000046 acyl-activating enzyme (AAE) consensus motif; other site 568815000047 active site 568815000048 AMP binding site [chemical binding]; other site 568815000049 substrate binding site [chemical binding]; other site 568815000050 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 568815000051 isochorismate synthases; Region: isochor_syn; TIGR00543 568815000052 Condensation domain; Region: Condensation; pfam00668 568815000053 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 568815000054 bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108 568815000055 Moco binding site; other site 568815000056 metal coordination site [ion binding]; other site 568815000057 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 568815000058 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 568815000059 pentapeptide MXKDX repeat protein; Region: penta_MxKDx; TIGR02953 568815000060 RNA polymerase sigma factor; Provisional; Region: PRK12539 568815000061 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 568815000062 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 568815000063 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4944 568815000064 Transcriptional regulators [Transcription]; Region: FadR; COG2186 568815000065 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568815000066 DNA-binding site [nucleotide binding]; DNA binding site 568815000067 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 568815000068 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 568815000069 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 568815000070 putative ligand binding site [chemical binding]; other site 568815000071 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 568815000072 TM-ABC transporter signature motif; other site 568815000073 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 568815000074 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 568815000075 TM-ABC transporter signature motif; other site 568815000076 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 568815000077 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 568815000078 Walker A/P-loop; other site 568815000079 ATP binding site [chemical binding]; other site 568815000080 Q-loop/lid; other site 568815000081 ABC transporter signature motif; other site 568815000082 Walker B; other site 568815000083 D-loop; other site 568815000084 H-loop/switch region; other site 568815000085 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 568815000086 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 568815000087 Walker A/P-loop; other site 568815000088 ATP binding site [chemical binding]; other site 568815000089 Q-loop/lid; other site 568815000090 ABC transporter signature motif; other site 568815000091 Walker B; other site 568815000092 D-loop; other site 568815000093 H-loop/switch region; other site 568815000094 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 568815000095 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 568815000096 active site 568815000097 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 568815000098 classical (c) SDRs; Region: SDR_c; cd05233 568815000099 NAD(P) binding site [chemical binding]; other site 568815000100 active site 568815000101 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 568815000102 classical (c) SDRs; Region: SDR_c; cd05233 568815000103 NAD(P) binding site [chemical binding]; other site 568815000104 active site 568815000105 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 568815000106 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 568815000107 tetramer interface [polypeptide binding]; other site 568815000108 TPP-binding site [chemical binding]; other site 568815000109 heterodimer interface [polypeptide binding]; other site 568815000110 phosphorylation loop region [posttranslational modification] 568815000111 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 568815000112 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 568815000113 alpha subunit interface [polypeptide binding]; other site 568815000114 TPP binding site [chemical binding]; other site 568815000115 heterodimer interface [polypeptide binding]; other site 568815000116 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 568815000117 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 568815000118 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 568815000119 E3 interaction surface; other site 568815000120 lipoyl attachment site [posttranslational modification]; other site 568815000121 e3 binding domain; Region: E3_binding; pfam02817 568815000122 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 568815000123 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 568815000124 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 568815000125 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 568815000126 shikimate binding site; other site 568815000127 NAD(P) binding site [chemical binding]; other site 568815000128 magnesium-transporting ATPase; Provisional; Region: PRK15122 568815000129 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 568815000130 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568815000131 Soluble P-type ATPase [General function prediction only]; Region: COG4087 568815000132 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 568815000133 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 568815000134 MgtC family; Region: MgtC; pfam02308 568815000135 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568815000136 ATP binding site [chemical binding]; other site 568815000137 Mg2+ binding site [ion binding]; other site 568815000138 G-X-G motif; other site 568815000139 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 568815000140 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568815000141 active site 568815000142 phosphorylation site [posttranslational modification] 568815000143 intermolecular recognition site; other site 568815000144 dimerization interface [polypeptide binding]; other site 568815000145 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568815000146 dimerization interface [polypeptide binding]; other site 568815000147 DNA binding residues [nucleotide binding] 568815000148 Response regulator receiver domain; Region: Response_reg; pfam00072 568815000149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568815000150 active site 568815000151 phosphorylation site [posttranslational modification] 568815000152 intermolecular recognition site; other site 568815000153 dimerization interface [polypeptide binding]; other site 568815000154 N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741 568815000155 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 568815000156 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 568815000157 active site 568815000158 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 568815000159 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 568815000160 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 568815000161 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 568815000162 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 568815000163 putative dimer interface [polypeptide binding]; other site 568815000164 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 568815000165 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 568815000166 tetramer interface [polypeptide binding]; other site 568815000167 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568815000168 catalytic residue [active] 568815000169 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 568815000170 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 568815000171 active site 568815000172 dimer interface [polypeptide binding]; other site 568815000173 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 568815000174 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 568815000175 active site 568815000176 FMN binding site [chemical binding]; other site 568815000177 substrate binding site [chemical binding]; other site 568815000178 3Fe-4S cluster binding site [ion binding]; other site 568815000179 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 568815000180 domain interface; other site 568815000181 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 568815000182 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 568815000183 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 568815000184 active site 568815000185 catalytic triad [active] 568815000186 oxyanion hole [active] 568815000187 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 568815000188 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 568815000189 ligand binding site [chemical binding]; other site 568815000190 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 568815000191 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 568815000192 ATP binding site [chemical binding]; other site 568815000193 Walker A motif; other site 568815000194 hexamer interface [polypeptide binding]; other site 568815000195 Walker B motif; other site 568815000196 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 568815000197 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 568815000198 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 568815000199 VirB7 interaction site; other site 568815000200 Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736 568815000201 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 568815000202 Type IV secretory pathway, VirB6 components [Intracellular trafficking and secretion]; Region: VirB6; COG3704 568815000203 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 568815000204 Type IV secretion system proteins; Region: T4SS; pfam07996 568815000205 Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451 568815000206 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 568815000207 Type IV secretory pathway, VirB3 components [Intracellular trafficking and secretion]; Region: VirB3; COG3702 568815000208 TrbC/VIRB2 family; Region: TrbC; pfam04956 568815000209 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 568815000210 N-acetyl-D-glucosamine binding site [chemical binding]; other site 568815000211 catalytic residue [active] 568815000212 lytic murein transglycosylase; Region: MltB_2; TIGR02283 568815000213 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 568815000214 N-acetyl-D-glucosamine binding site [chemical binding]; other site 568815000215 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 568815000216 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 568815000217 active site 568815000218 tetramer interface; other site 568815000219 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5338 568815000220 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 568815000221 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 568815000222 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 568815000223 putative active site [active] 568815000224 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 568815000225 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 568815000226 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 568815000227 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 568815000228 ferrochelatase; Reviewed; Region: hemH; PRK00035 568815000229 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 568815000230 C-terminal domain interface [polypeptide binding]; other site 568815000231 active site 568815000232 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 568815000233 active site 568815000234 N-terminal domain interface [polypeptide binding]; other site 568815000235 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 568815000236 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 568815000237 hypothetical protein; Provisional; Region: PRK07546 568815000238 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 568815000239 substrate-cofactor binding pocket; other site 568815000240 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568815000241 homodimer interface [polypeptide binding]; other site 568815000242 catalytic residue [active] 568815000243 aminodeoxychorismate synthase; Provisional; Region: PRK07508 568815000244 chorismate binding enzyme; Region: Chorismate_bind; cl10555 568815000245 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 568815000246 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 568815000247 active site 568815000248 Zn binding site [ion binding]; other site 568815000249 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 568815000250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568815000251 active site 568815000252 phosphorylation site [posttranslational modification] 568815000253 intermolecular recognition site; other site 568815000254 dimerization interface [polypeptide binding]; other site 568815000255 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568815000256 Walker A motif; other site 568815000257 ATP binding site [chemical binding]; other site 568815000258 Walker B motif; other site 568815000259 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 568815000260 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 568815000261 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 568815000262 active site 568815000263 intersubunit interface [polypeptide binding]; other site 568815000264 catalytic residue [active] 568815000265 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 568815000266 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 568815000267 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 568815000268 active site residue [active] 568815000269 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 568815000270 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 568815000271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815000272 dimer interface [polypeptide binding]; other site 568815000273 conserved gate region; other site 568815000274 putative PBP binding loops; other site 568815000275 ABC-ATPase subunit interface; other site 568815000276 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 568815000277 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568815000278 Walker A/P-loop; other site 568815000279 ATP binding site [chemical binding]; other site 568815000280 Q-loop/lid; other site 568815000281 ABC transporter signature motif; other site 568815000282 Walker B; other site 568815000283 D-loop; other site 568815000284 H-loop/switch region; other site 568815000285 TOBE domain; Region: TOBE; cl01440 568815000286 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 568815000287 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 568815000288 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 568815000289 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568815000290 LysR family transcriptional regulator; Provisional; Region: PRK14997 568815000291 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 568815000292 putative effector binding pocket; other site 568815000293 dimerization interface [polypeptide binding]; other site 568815000294 amidase; Provisional; Region: PRK08310 568815000295 indole-3-acetamide amidohydrolase; Region: PLN02722 568815000296 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 568815000297 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 568815000298 dimer interface [polypeptide binding]; other site 568815000299 active site 568815000300 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 568815000301 catalytic residues [active] 568815000302 substrate binding site [chemical binding]; other site 568815000303 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 568815000304 Chain length determinant protein; Region: Wzz; pfam02706 568815000305 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 568815000306 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 568815000307 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 568815000308 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 568815000309 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 568815000310 active site 568815000311 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 568815000312 O-Antigen ligase; Region: Wzy_C; pfam04932 568815000313 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 568815000314 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 568815000315 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 568815000316 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 568815000317 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 568815000318 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362 568815000319 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 568815000320 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 568815000321 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 568815000322 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568815000323 Walker A/P-loop; other site 568815000324 ATP binding site [chemical binding]; other site 568815000325 Q-loop/lid; other site 568815000326 ABC transporter signature motif; other site 568815000327 Walker B; other site 568815000328 D-loop; other site 568815000329 H-loop/switch region; other site 568815000330 TOBE domain; Region: TOBE_2; pfam08402 568815000331 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 568815000332 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815000333 dimer interface [polypeptide binding]; other site 568815000334 conserved gate region; other site 568815000335 putative PBP binding loops; other site 568815000336 ABC-ATPase subunit interface; other site 568815000337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815000338 dimer interface [polypeptide binding]; other site 568815000339 conserved gate region; other site 568815000340 putative PBP binding loops; other site 568815000341 ABC-ATPase subunit interface; other site 568815000342 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 568815000343 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 568815000344 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 568815000345 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568815000346 putative substrate translocation pore; other site 568815000347 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568815000348 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568815000349 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 568815000350 Autoinducer binding domain; Region: Autoind_bind; pfam03472 568815000351 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568815000352 DNA binding residues [nucleotide binding] 568815000353 dimerization interface [polypeptide binding]; other site 568815000354 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 568815000355 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 568815000356 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 568815000357 FliG C-terminal domain; Region: FliG_C; pfam01706 568815000358 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 568815000359 Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868 568815000360 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 568815000361 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 568815000362 flagellar motor protein MotA; Validated; Region: PRK09110 568815000363 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 568815000364 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 568815000365 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642 568815000366 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 568815000367 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 568815000368 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002 568815000369 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 568815000370 Walker A motif; other site 568815000371 ATP binding site [chemical binding]; other site 568815000372 Walker B motif; other site 568815000373 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 568815000374 active site 568815000375 GtrA-like protein; Region: GtrA; pfam04138 568815000376 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 568815000377 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 568815000378 Ligand binding site; other site 568815000379 Putative Catalytic site; other site 568815000380 DXD motif; other site 568815000381 Peptidase family M48; Region: Peptidase_M48; cl12018 568815000382 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 568815000383 putative active site [active] 568815000384 YdjC motif; other site 568815000385 Mg binding site [ion binding]; other site 568815000386 putative homodimer interface [polypeptide binding]; other site 568815000387 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 568815000388 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 568815000389 Helix-turn-helix domain; Region: HTH_18; pfam12833 568815000390 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568815000391 Transposase; Region: HTH_Tnp_1; cl17663 568815000392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568815000393 D-galactonate transporter; Region: 2A0114; TIGR00893 568815000394 putative substrate translocation pore; other site 568815000395 putative aldolase; Validated; Region: PRK08130 568815000396 intersubunit interface [polypeptide binding]; other site 568815000397 active site 568815000398 Zn2+ binding site [ion binding]; other site 568815000399 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 568815000400 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 568815000401 putative NAD(P) binding site [chemical binding]; other site 568815000402 active site 568815000403 putative substrate binding site [chemical binding]; other site 568815000404 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 568815000405 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 568815000406 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 568815000407 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 568815000408 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 568815000409 Metal-binding active site; metal-binding site 568815000410 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 568815000411 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 568815000412 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003 568815000413 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782 568815000414 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 568815000415 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 568815000416 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790 568815000417 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 568815000418 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 568815000419 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK06005 568815000420 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 568815000421 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 568815000422 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 568815000423 Uncharacterized conserved protein [Function unknown]; Region: COG3334 568815000424 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 568815000425 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 568815000426 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 568815000427 FliP family; Region: FliP; cl00593 568815000428 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4893 568815000429 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568815000430 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568815000431 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 568815000432 putative dimerization interface [polypeptide binding]; other site 568815000433 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568815000434 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568815000435 Uncharacterized conserved protein [Function unknown]; Region: COG3777 568815000436 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 568815000437 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 568815000438 active site 2 [active] 568815000439 active site 1 [active] 568815000440 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 568815000441 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 568815000442 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568815000443 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568815000444 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568815000445 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568815000446 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568815000447 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 568815000448 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 568815000449 Autotransporter beta-domain; Region: Autotransporter; pfam03797 568815000450 Cytochrome c2 [Energy production and conversion]; Region: COG3474 568815000451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 568815000452 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 568815000453 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568815000454 DNA-binding site [nucleotide binding]; DNA binding site 568815000455 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 568815000456 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568815000457 transcriptional activator TtdR; Provisional; Region: PRK09801 568815000458 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 568815000459 putative effector binding pocket; other site 568815000460 dimerization interface [polypeptide binding]; other site 568815000461 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 568815000462 FAD binding domain; Region: FAD_binding_4; pfam01565 568815000463 FAD binding domain; Region: FAD_binding_4; pfam01565 568815000464 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 568815000465 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 568815000466 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 568815000467 Cysteine-rich domain; Region: CCG; pfam02754 568815000468 Cysteine-rich domain; Region: CCG; pfam02754 568815000469 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 568815000470 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568815000471 active site 568815000472 catalytic tetrad [active] 568815000473 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 568815000474 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 568815000475 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 568815000476 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 568815000477 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 568815000478 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 568815000479 dimer interface [polypeptide binding]; other site 568815000480 motif 1; other site 568815000481 motif 2; other site 568815000482 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 568815000483 active site 568815000484 motif 3; other site 568815000485 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 568815000486 anticodon binding site; other site 568815000487 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 568815000488 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 568815000489 motif 1; other site 568815000490 dimer interface [polypeptide binding]; other site 568815000491 active site 568815000492 motif 2; other site 568815000493 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 568815000494 active site 568815000495 motif 3; other site 568815000496 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583 568815000497 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 568815000498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568815000499 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568815000500 putative substrate translocation pore; other site 568815000501 glucose/galactose transporter; Region: gluP; TIGR01272 568815000502 Predicted membrane protein [Function unknown]; Region: COG2259 568815000503 fumarate hydratase; Reviewed; Region: fumC; PRK00485 568815000504 Class II fumarases; Region: Fumarase_classII; cd01362 568815000505 active site 568815000506 tetramer interface [polypeptide binding]; other site 568815000507 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 568815000508 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 568815000509 ring oligomerisation interface [polypeptide binding]; other site 568815000510 ATP/Mg binding site [chemical binding]; other site 568815000511 stacking interactions; other site 568815000512 hinge regions; other site 568815000513 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 568815000514 oligomerisation interface [polypeptide binding]; other site 568815000515 mobile loop; other site 568815000516 roof hairpin; other site 568815000517 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 568815000518 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 568815000519 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 568815000520 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 568815000521 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 568815000522 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 568815000523 active site 568815000524 Riboflavin kinase; Region: Flavokinase; smart00904 568815000525 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 568815000526 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 568815000527 active site 568815000528 HIGH motif; other site 568815000529 nucleotide binding site [chemical binding]; other site 568815000530 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 568815000531 active site 568815000532 KMSKS motif; other site 568815000533 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 568815000534 tRNA binding surface [nucleotide binding]; other site 568815000535 anticodon binding site; other site 568815000536 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 568815000537 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 568815000538 nucleoside/Zn binding site; other site 568815000539 dimer interface [polypeptide binding]; other site 568815000540 catalytic motif [active] 568815000541 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 568815000542 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568815000543 RNA binding surface [nucleotide binding]; other site 568815000544 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 568815000545 active site 568815000546 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 568815000547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568815000548 S-adenosylmethionine binding site [chemical binding]; other site 568815000549 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 568815000550 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 568815000551 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 568815000552 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 568815000553 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 568815000554 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 568815000555 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 568815000556 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 568815000557 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 568815000558 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 568815000559 TrkA-N domain; Region: TrkA_N; pfam02254 568815000560 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 568815000561 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 568815000562 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 568815000563 active site 568815000564 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 568815000565 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 568815000566 putative acyl-acceptor binding pocket; other site 568815000567 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 568815000568 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 568815000569 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 568815000570 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 568815000571 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 568815000572 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908 568815000573 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 568815000574 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568815000575 ATP binding site [chemical binding]; other site 568815000576 Mg2+ binding site [ion binding]; other site 568815000577 G-X-G motif; other site 568815000578 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 568815000579 ATP binding site [chemical binding]; other site 568815000580 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 568815000581 benzoate transport; Region: 2A0115; TIGR00895 568815000582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568815000583 putative substrate translocation pore; other site 568815000584 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 568815000585 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 568815000586 active site 568815000587 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 568815000588 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568815000589 Bacterial transcriptional regulator; Region: IclR; pfam01614 568815000590 enoyl-CoA hydratase; Provisional; Region: PRK08138 568815000591 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568815000592 substrate binding site [chemical binding]; other site 568815000593 oxyanion hole (OAH) forming residues; other site 568815000594 trimer interface [polypeptide binding]; other site 568815000595 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 568815000596 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 568815000597 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 568815000598 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 568815000599 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568815000600 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568815000601 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 568815000602 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 568815000603 putative active site [active] 568815000604 putative FMN binding site [chemical binding]; other site 568815000605 putative substrate binding site [chemical binding]; other site 568815000606 putative catalytic residue [active] 568815000607 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg7; cd04786 568815000608 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 568815000609 DNA binding residues [nucleotide binding] 568815000610 putative dimer interface [polypeptide binding]; other site 568815000611 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 568815000612 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 568815000613 potential catalytic triad [active] 568815000614 conserved cys residue [active] 568815000615 sensor protein QseC; Provisional; Region: PRK10337 568815000616 HAMP domain; Region: HAMP; pfam00672 568815000617 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568815000618 dimer interface [polypeptide binding]; other site 568815000619 phosphorylation site [posttranslational modification] 568815000620 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568815000621 Mg2+ binding site [ion binding]; other site 568815000622 G-X-G motif; other site 568815000623 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568815000624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568815000625 active site 568815000626 phosphorylation site [posttranslational modification] 568815000627 intermolecular recognition site; other site 568815000628 dimerization interface [polypeptide binding]; other site 568815000629 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568815000630 DNA binding site [nucleotide binding] 568815000631 Uncharacterized conserved protein [Function unknown]; Region: COG5591 568815000632 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 568815000633 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 568815000634 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 568815000635 Flavodoxin; Region: Flavodoxin_1; pfam00258 568815000636 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like2; cd06201 568815000637 FAD binding pocket [chemical binding]; other site 568815000638 FAD binding motif [chemical binding]; other site 568815000639 catalytic residues [active] 568815000640 NAD binding pocket [chemical binding]; other site 568815000641 phosphate binding motif [ion binding]; other site 568815000642 beta-alpha-beta structure motif; other site 568815000643 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 568815000644 ApbE family; Region: ApbE; pfam02424 568815000645 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 568815000646 GAF domain; Region: GAF; pfam01590 568815000647 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 568815000648 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 568815000649 metal binding site [ion binding]; metal-binding site 568815000650 active site 568815000651 I-site; other site 568815000652 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 568815000653 EamA-like transporter family; Region: EamA; pfam00892 568815000654 EamA-like transporter family; Region: EamA; cl17759 568815000655 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568815000656 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568815000657 DNA-binding site [nucleotide binding]; DNA binding site 568815000658 FCD domain; Region: FCD; pfam07729 568815000659 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 568815000660 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 568815000661 inhibitor site; inhibition site 568815000662 active site 568815000663 dimer interface [polypeptide binding]; other site 568815000664 catalytic residue [active] 568815000665 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 568815000666 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 568815000667 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 568815000668 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 568815000669 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 568815000670 Cytochrome c; Region: Cytochrom_C; pfam00034 568815000671 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 568815000672 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 568815000673 Binuclear center (active site) [active] 568815000674 K-pathway; other site 568815000675 Putative proton exit pathway; other site 568815000676 MoxR-like ATPases [General function prediction only]; Region: COG0714 568815000677 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568815000678 Walker A motif; other site 568815000679 ATP binding site [chemical binding]; other site 568815000680 Walker B motif; other site 568815000681 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 568815000682 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 568815000683 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 568815000684 metal ion-dependent adhesion site (MIDAS); other site 568815000685 Uncharacterized conserved protein [Function unknown]; Region: COG4309 568815000686 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 568815000687 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 568815000688 CPxP motif; other site 568815000689 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 568815000690 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 568815000691 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 568815000692 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 568815000693 nucleophilic elbow; other site 568815000694 catalytic triad; other site 568815000695 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 568815000696 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 568815000697 Multicopper oxidase; Region: Cu-oxidase; pfam00394 568815000698 Uncharacterized conserved protein [Function unknown]; Region: COG1262 568815000699 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 568815000700 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 568815000701 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 568815000702 ligand binding site [chemical binding]; other site 568815000703 flexible hinge region; other site 568815000704 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 568815000705 putative switch regulator; other site 568815000706 non-specific DNA interactions [nucleotide binding]; other site 568815000707 DNA binding site [nucleotide binding] 568815000708 sequence specific DNA binding site [nucleotide binding]; other site 568815000709 putative cAMP binding site [chemical binding]; other site 568815000710 Transcriptional regulators [Transcription]; Region: PurR; COG1609 568815000711 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568815000712 DNA binding site [nucleotide binding] 568815000713 domain linker motif; other site 568815000714 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 568815000715 dimerization interface [polypeptide binding]; other site 568815000716 ligand binding site [chemical binding]; other site 568815000717 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 568815000718 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 568815000719 putative ligand binding site [chemical binding]; other site 568815000720 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568815000721 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568815000722 Walker A/P-loop; other site 568815000723 ATP binding site [chemical binding]; other site 568815000724 Q-loop/lid; other site 568815000725 ABC transporter signature motif; other site 568815000726 Walker B; other site 568815000727 D-loop; other site 568815000728 H-loop/switch region; other site 568815000729 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 568815000730 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568815000731 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 568815000732 TM-ABC transporter signature motif; other site 568815000733 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 568815000734 classical (c) SDRs; Region: SDR_c; cd05233 568815000735 NAD(P) binding site [chemical binding]; other site 568815000736 active site 568815000737 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 568815000738 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 568815000739 N- and C-terminal domain interface [polypeptide binding]; other site 568815000740 active site 568815000741 MgATP binding site [chemical binding]; other site 568815000742 catalytic site [active] 568815000743 metal binding site [ion binding]; metal-binding site 568815000744 carbohydrate binding site [chemical binding]; other site 568815000745 putative homodimer interface [polypeptide binding]; other site 568815000746 RES domain; Region: RES; smart00953 568815000747 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 568815000748 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 568815000749 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 568815000750 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 568815000751 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 568815000752 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 568815000753 4Fe-4S binding domain; Region: Fer4_5; pfam12801 568815000754 4Fe-4S binding domain; Region: Fer4_5; pfam12801 568815000755 nitrous-oxide reductase; Validated; Region: PRK02888 568815000756 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 568815000757 Nitrous oxidase accessory protein [Inorganic ion transport and metabolism]; Region: NosD; COG3420 568815000758 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 568815000759 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 568815000760 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568815000761 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568815000762 Walker A/P-loop; other site 568815000763 ATP binding site [chemical binding]; other site 568815000764 Q-loop/lid; other site 568815000765 ABC transporter signature motif; other site 568815000766 Walker B; other site 568815000767 D-loop; other site 568815000768 H-loop/switch region; other site 568815000769 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 568815000770 Predicted lipoprotein involved in nitrous oxide reduction [Energy production and conversion]; Region: NosL; COG4314 568815000771 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 568815000772 ApbE family; Region: ApbE; pfam02424 568815000773 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 568815000774 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 568815000775 ligand binding site [chemical binding]; other site 568815000776 flexible hinge region; other site 568815000777 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 568815000778 putative switch regulator; other site 568815000779 non-specific DNA interactions [nucleotide binding]; other site 568815000780 DNA binding site [nucleotide binding] 568815000781 sequence specific DNA binding site [nucleotide binding]; other site 568815000782 putative cAMP binding site [chemical binding]; other site 568815000783 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 568815000784 pseudoazurin; Region: pseudoazurin; TIGR02375 568815000785 Uncharacterized protein involved in response to NO [Inorganic ion transport and metabolism]; Region: NnrS; COG3213 568815000786 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 568815000787 NMT1-like family; Region: NMT1_2; pfam13379 568815000788 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 568815000789 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815000790 dimer interface [polypeptide binding]; other site 568815000791 conserved gate region; other site 568815000792 putative PBP binding loops; other site 568815000793 ABC-ATPase subunit interface; other site 568815000794 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 568815000795 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 568815000796 Walker A/P-loop; other site 568815000797 ATP binding site [chemical binding]; other site 568815000798 Q-loop/lid; other site 568815000799 ABC transporter signature motif; other site 568815000800 Walker B; other site 568815000801 D-loop; other site 568815000802 H-loop/switch region; other site 568815000803 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 568815000804 putative protease; Provisional; Region: PRK15447 568815000805 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 568815000806 Peptidase family U32; Region: Peptidase_U32; pfam01136 568815000807 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 568815000808 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 568815000809 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 568815000810 Flavoprotein; Region: Flavoprotein; pfam02441 568815000811 Protein of unknown function (DUF2478); Region: DUF2478; pfam10649 568815000812 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 568815000813 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 568815000814 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 568815000815 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 568815000816 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 568815000817 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 568815000818 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 568815000819 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 568815000820 [4Fe-4S] binding site [ion binding]; other site 568815000821 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 568815000822 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 568815000823 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 568815000824 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 568815000825 molybdopterin cofactor binding site; other site 568815000826 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 568815000827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568815000828 putative substrate translocation pore; other site 568815000829 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 568815000830 transcriptional activator FtrB; Provisional; Region: ftrB; PRK09392 568815000831 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 568815000832 ligand binding site [chemical binding]; other site 568815000833 flexible hinge region; other site 568815000834 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 568815000835 Transcriptional regulators [Transcription]; Region: PurR; COG1609 568815000836 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568815000837 DNA binding site [nucleotide binding] 568815000838 domain linker motif; other site 568815000839 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 568815000840 ligand binding site [chemical binding]; other site 568815000841 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 568815000842 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 568815000843 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 568815000844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815000845 dimer interface [polypeptide binding]; other site 568815000846 conserved gate region; other site 568815000847 putative PBP binding loops; other site 568815000848 ABC-ATPase subunit interface; other site 568815000849 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 568815000850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815000851 dimer interface [polypeptide binding]; other site 568815000852 conserved gate region; other site 568815000853 putative PBP binding loops; other site 568815000854 ABC-ATPase subunit interface; other site 568815000855 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 568815000856 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 568815000857 Walker A/P-loop; other site 568815000858 ATP binding site [chemical binding]; other site 568815000859 Q-loop/lid; other site 568815000860 ABC transporter signature motif; other site 568815000861 Walker B; other site 568815000862 D-loop; other site 568815000863 H-loop/switch region; other site 568815000864 TOBE domain; Region: TOBE_2; pfam08402 568815000865 Trehalose utilization protein [Carbohydrate transport and metabolism]; Region: ThuA; COG4813 568815000866 conserved cys residue [active] 568815000867 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 568815000868 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 568815000869 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 568815000870 Transmembrane secretion effector; Region: MFS_3; pfam05977 568815000871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568815000872 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568815000873 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 568815000874 catalytic residues [active] 568815000875 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 568815000876 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 568815000877 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 568815000878 Class I ribonucleotide reductase; Region: RNR_I; cd01679 568815000879 active site 568815000880 dimer interface [polypeptide binding]; other site 568815000881 catalytic residues [active] 568815000882 effector binding site; other site 568815000883 R2 peptide binding site; other site 568815000884 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 568815000885 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 568815000886 dimer interface [polypeptide binding]; other site 568815000887 putative radical transfer pathway; other site 568815000888 diiron center [ion binding]; other site 568815000889 tyrosyl radical; other site 568815000890 septum formation inhibitor; Reviewed; Region: minC; PRK05177 568815000891 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 568815000892 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 568815000893 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 568815000894 Switch I; other site 568815000895 Switch II; other site 568815000896 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 568815000897 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 568815000898 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 568815000899 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 568815000900 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 568815000901 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 568815000902 Walker A/P-loop; other site 568815000903 ATP binding site [chemical binding]; other site 568815000904 Q-loop/lid; other site 568815000905 ABC transporter signature motif; other site 568815000906 Walker B; other site 568815000907 D-loop; other site 568815000908 H-loop/switch region; other site 568815000909 TOBE domain; Region: TOBE_2; pfam08402 568815000910 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 568815000911 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815000912 dimer interface [polypeptide binding]; other site 568815000913 conserved gate region; other site 568815000914 putative PBP binding loops; other site 568815000915 ABC-ATPase subunit interface; other site 568815000916 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 568815000917 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 568815000918 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 568815000919 HlyD family secretion protein; Region: HlyD_3; pfam13437 568815000920 Predicted membrane protein [Function unknown]; Region: COG4803 568815000921 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 568815000922 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 568815000923 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568815000924 catalytic residue [active] 568815000925 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 568815000926 glutaminase; Reviewed; Region: PRK12356 568815000927 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 568815000928 acid-resistance protein; Provisional; Region: PRK10208 568815000929 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 568815000930 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 568815000931 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 568815000932 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 568815000933 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568815000934 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568815000935 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 568815000936 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 568815000937 Substrate binding site; other site 568815000938 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 568815000939 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 568815000940 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 568815000941 active site 568815000942 substrate binding site [chemical binding]; other site 568815000943 metal binding site [ion binding]; metal-binding site 568815000944 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 568815000945 putative active site pocket [active] 568815000946 cleavage site 568815000947 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 568815000948 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 568815000949 putative ion selectivity filter; other site 568815000950 putative pore gating glutamate residue; other site 568815000951 putative H+/Cl- coupling transport residue; other site 568815000952 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 568815000953 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 568815000954 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 568815000955 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 568815000956 active site 568815000957 Cytochrome c [Energy production and conversion]; Region: COG3258 568815000958 Cytochrome c; Region: Cytochrom_C; pfam00034 568815000959 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 568815000960 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568815000961 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 568815000962 dimerization interface [polypeptide binding]; other site 568815000963 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 568815000964 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 568815000965 tetramer interface [polypeptide binding]; other site 568815000966 heme binding pocket [chemical binding]; other site 568815000967 NADPH binding site [chemical binding]; other site 568815000968 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 568815000969 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 568815000970 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 568815000971 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 568815000972 CoenzymeA binding site [chemical binding]; other site 568815000973 subunit interaction site [polypeptide binding]; other site 568815000974 PHB binding site; other site 568815000975 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06026 568815000976 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, putative; Region: MTA/SAH-nuc-hyp; TIGR01705 568815000977 GMP synthase; Reviewed; Region: guaA; PRK00074 568815000978 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 568815000979 AMP/PPi binding site [chemical binding]; other site 568815000980 candidate oxyanion hole; other site 568815000981 catalytic triad [active] 568815000982 potential glutamine specificity residues [chemical binding]; other site 568815000983 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 568815000984 ATP Binding subdomain [chemical binding]; other site 568815000985 Ligand Binding sites [chemical binding]; other site 568815000986 Dimerization subdomain; other site 568815000987 integrase; Provisional; Region: PRK09692 568815000988 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 568815000989 active site 568815000990 Int/Topo IB signature motif; other site 568815000991 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 568815000992 Replication initiator protein A; Region: RPA; pfam10134 568815000993 P-type conjugative transfer protein TrbL; Region: TrbL_P; TIGR02783 568815000994 P-type conjugative transfer protein TrbJ; Region: TrbJ_Ti; TIGR02780 568815000995 TraC-like protein; Region: TraC; cl06725 568815000996 conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877 568815000997 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 568815000998 conjugal transfer relaxase TraI; Provisional; Region: PRK13878 568815000999 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 568815001000 Predicted ATPase [General function prediction only]; Region: COG5293 568815001001 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 568815001002 DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077 568815001003 Uncharacterized protein probably involved in high-affinity Fe2+ transport [Inorganic ion transport and metabolism]; Region: Tpd; COG3470 568815001004 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 568815001005 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 568815001006 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 568815001007 4Fe-4S binding domain; Region: Fer4_5; pfam12801 568815001008 putative phosphoketolase; Provisional; Region: PRK05261 568815001009 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 568815001010 TPP-binding site; other site 568815001011 XFP C-terminal domain; Region: XFP_C; pfam09363 568815001012 acetate kinase; Provisional; Region: PRK07058 568815001013 propionate/acetate kinase; Provisional; Region: PRK12379 568815001014 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 568815001015 Cytochrome P450; Region: p450; cl12078 568815001016 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568815001017 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568815001018 DNA-binding site [nucleotide binding]; DNA binding site 568815001019 FCD domain; Region: FCD; pfam07729 568815001020 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 568815001021 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 568815001022 NAD(P) binding site [chemical binding]; other site 568815001023 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 568815001024 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 568815001025 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568815001026 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 568815001027 TM-ABC transporter signature motif; other site 568815001028 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 568815001029 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 568815001030 TM-ABC transporter signature motif; other site 568815001031 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 568815001032 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 568815001033 Walker A/P-loop; other site 568815001034 ATP binding site [chemical binding]; other site 568815001035 Q-loop/lid; other site 568815001036 ABC transporter signature motif; other site 568815001037 Walker B; other site 568815001038 D-loop; other site 568815001039 H-loop/switch region; other site 568815001040 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 568815001041 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 568815001042 Walker A/P-loop; other site 568815001043 ATP binding site [chemical binding]; other site 568815001044 Q-loop/lid; other site 568815001045 ABC transporter signature motif; other site 568815001046 Walker B; other site 568815001047 D-loop; other site 568815001048 H-loop/switch region; other site 568815001049 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 568815001050 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568815001051 NAD(P) binding site [chemical binding]; other site 568815001052 active site 568815001053 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 568815001054 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 568815001055 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 568815001056 shikimate binding site; other site 568815001057 NAD(P) binding site [chemical binding]; other site 568815001058 choline dehydrogenase; Validated; Region: PRK02106 568815001059 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 568815001060 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 568815001061 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 568815001062 tetramerization interface [polypeptide binding]; other site 568815001063 NAD(P) binding site [chemical binding]; other site 568815001064 catalytic residues [active] 568815001065 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 568815001066 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 568815001067 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 568815001068 Zinc-dependent alcohol dehydrogenases (ADH) and class III ADG (AKA formaldehyde dehydrogenase); Region: liver_ADH_like1; cd08281 568815001069 NAD binding site [chemical binding]; other site 568815001070 catalytic Zn binding site [ion binding]; other site 568815001071 substrate binding site [chemical binding]; other site 568815001072 structural Zn binding site [ion binding]; other site 568815001073 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 568815001074 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 568815001075 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 568815001076 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568815001077 Walker A/P-loop; other site 568815001078 ATP binding site [chemical binding]; other site 568815001079 Q-loop/lid; other site 568815001080 ABC transporter signature motif; other site 568815001081 Walker B; other site 568815001082 D-loop; other site 568815001083 H-loop/switch region; other site 568815001084 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 568815001085 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 568815001086 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568815001087 Walker A/P-loop; other site 568815001088 ATP binding site [chemical binding]; other site 568815001089 Q-loop/lid; other site 568815001090 ABC transporter signature motif; other site 568815001091 Walker B; other site 568815001092 D-loop; other site 568815001093 H-loop/switch region; other site 568815001094 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 568815001095 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 568815001096 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 568815001097 inhibitor site; inhibition site 568815001098 active site 568815001099 dimer interface [polypeptide binding]; other site 568815001100 catalytic residue [active] 568815001101 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 568815001102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815001103 dimer interface [polypeptide binding]; other site 568815001104 conserved gate region; other site 568815001105 putative PBP binding loops; other site 568815001106 ABC-ATPase subunit interface; other site 568815001107 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 568815001108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815001109 dimer interface [polypeptide binding]; other site 568815001110 conserved gate region; other site 568815001111 putative PBP binding loops; other site 568815001112 ABC-ATPase subunit interface; other site 568815001113 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 568815001114 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 568815001115 Transcriptional regulators [Transcription]; Region: FadR; COG2186 568815001116 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568815001117 DNA-binding site [nucleotide binding]; DNA binding site 568815001118 FCD domain; Region: FCD; pfam07729 568815001119 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 568815001120 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 568815001121 putative active site cavity [active] 568815001122 N-acetylmannosamine kinase; Provisional; Region: PRK05082 568815001123 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 568815001124 nucleotide binding site [chemical binding]; other site 568815001125 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 568815001126 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 568815001127 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 568815001128 ligand binding site [chemical binding]; other site 568815001129 flexible hinge region; other site 568815001130 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 568815001131 putative switch regulator; other site 568815001132 non-specific DNA interactions [nucleotide binding]; other site 568815001133 DNA binding site [nucleotide binding] 568815001134 sequence specific DNA binding site [nucleotide binding]; other site 568815001135 putative cAMP binding site [chemical binding]; other site 568815001136 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 568815001137 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568815001138 DNA binding residues [nucleotide binding] 568815001139 dimerization interface [polypeptide binding]; other site 568815001140 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 568815001141 Chain length determinant protein; Region: Wzz; cl15801 568815001142 AAA domain; Region: AAA_31; pfam13614 568815001143 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 568815001144 G3 box; other site 568815001145 Switch II region; other site 568815001146 G4 box; other site 568815001147 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 568815001148 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 568815001149 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 568815001150 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 568815001151 NADP binding site [chemical binding]; other site 568815001152 active site 568815001153 putative substrate binding site [chemical binding]; other site 568815001154 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 568815001155 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 568815001156 NADP-binding site; other site 568815001157 homotetramer interface [polypeptide binding]; other site 568815001158 substrate binding site [chemical binding]; other site 568815001159 homodimer interface [polypeptide binding]; other site 568815001160 active site 568815001161 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568815001162 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 568815001163 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568815001164 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 568815001165 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568815001166 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 568815001167 putative ADP-binding pocket [chemical binding]; other site 568815001168 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 568815001169 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 568815001170 putative trimer interface [polypeptide binding]; other site 568815001171 putative active site [active] 568815001172 putative substrate binding site [chemical binding]; other site 568815001173 putative CoA binding site [chemical binding]; other site 568815001174 Uncharacterized conserved protein [Function unknown]; Region: COG1434 568815001175 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 568815001176 putative active site [active] 568815001177 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 568815001178 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 568815001179 putative metal binding site; other site 568815001180 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 568815001181 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 568815001182 Mg++ binding site [ion binding]; other site 568815001183 putative catalytic motif [active] 568815001184 substrate binding site [chemical binding]; other site 568815001185 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 568815001186 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 568815001187 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 568815001188 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 568815001189 active site 568815001190 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 568815001191 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 568815001192 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 568815001193 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568815001194 glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209 568815001195 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 568815001196 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568815001197 catalytic residue [active] 568815001198 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 568815001199 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 568815001200 extended (e) SDRs; Region: SDR_e; cd08946 568815001201 NAD(P) binding site [chemical binding]; other site 568815001202 active site 568815001203 substrate binding site [chemical binding]; other site 568815001204 Uncharacterized protein conserved in bacteria with an aminopeptidase-like domain [General function prediction only]; Region: COG4310 568815001205 M28 Zn-Peptidases; Region: M28_like_3; cd05644 568815001206 active site 568815001207 metal binding site [ion binding]; metal-binding site 568815001208 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 568815001209 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 568815001210 Methyltransferase domain; Region: Methyltransf_23; pfam13489 568815001211 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568815001212 S-adenosylmethionine binding site [chemical binding]; other site 568815001213 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 568815001214 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 568815001215 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 568815001216 active site 568815001217 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 568815001218 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 568815001219 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 568815001220 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 568815001221 N- and C-terminal domain interface [polypeptide binding]; other site 568815001222 active site 568815001223 MgATP binding site [chemical binding]; other site 568815001224 catalytic site [active] 568815001225 metal binding site [ion binding]; metal-binding site 568815001226 glycerol binding site [chemical binding]; other site 568815001227 homotetramer interface [polypeptide binding]; other site 568815001228 homodimer interface [polypeptide binding]; other site 568815001229 FBP binding site [chemical binding]; other site 568815001230 protein IIAGlc interface [polypeptide binding]; other site 568815001231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568815001232 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568815001233 putative substrate translocation pore; other site 568815001234 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 568815001235 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568815001236 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 568815001237 putative dimerization interface [polypeptide binding]; other site 568815001238 putative substrate binding pocket [chemical binding]; other site 568815001239 methionine sulfoxide reductase B; Provisional; Region: PRK00222 568815001240 SelR domain; Region: SelR; pfam01641 568815001241 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 568815001242 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 568815001243 active site 568815001244 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 568815001245 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 568815001246 dimer interface [polypeptide binding]; other site 568815001247 active site 568815001248 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 568815001249 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 568815001250 NAD binding site [chemical binding]; other site 568815001251 homodimer interface [polypeptide binding]; other site 568815001252 homotetramer interface [polypeptide binding]; other site 568815001253 active site 568815001254 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 568815001255 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_2; cd05973 568815001256 active site 568815001257 acyl-activating enzyme (AAE) consensus motif; other site 568815001258 putative CoA binding site [chemical binding]; other site 568815001259 AMP binding site [chemical binding]; other site 568815001260 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 568815001261 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 568815001262 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568815001263 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 568815001264 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 568815001265 ligand binding site [chemical binding]; other site 568815001266 NAD binding site [chemical binding]; other site 568815001267 tetramer interface [polypeptide binding]; other site 568815001268 catalytic site [active] 568815001269 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 568815001270 L-serine binding site [chemical binding]; other site 568815001271 ACT domain interface; other site 568815001272 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 568815001273 active site 568815001274 catalytic residues [active] 568815001275 metal binding site [ion binding]; metal-binding site 568815001276 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 568815001277 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568815001278 dimerization interface [polypeptide binding]; other site 568815001279 putative DNA binding site [nucleotide binding]; other site 568815001280 putative Zn2+ binding site [ion binding]; other site 568815001281 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 568815001282 Predicted transporter component [General function prediction only]; Region: COG2391 568815001283 Predicted transporter component [General function prediction only]; Region: COG2391 568815001284 Sulphur transport; Region: Sulf_transp; pfam04143 568815001285 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568815001286 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568815001287 DNA-binding site [nucleotide binding]; DNA binding site 568815001288 FCD domain; Region: FCD; pfam07729 568815001289 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 568815001290 Domain of unknown function DUF20; Region: UPF0118; pfam01594 568815001291 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 568815001292 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568815001293 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 568815001294 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 568815001295 Peptidase family M23; Region: Peptidase_M23; pfam01551 568815001296 HlyD family secretion protein; Region: HlyD_3; pfam13437 568815001297 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568815001298 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568815001299 Walker A/P-loop; other site 568815001300 ATP binding site [chemical binding]; other site 568815001301 Q-loop/lid; other site 568815001302 ABC transporter signature motif; other site 568815001303 Walker B; other site 568815001304 D-loop; other site 568815001305 H-loop/switch region; other site 568815001306 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 568815001307 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 568815001308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815001309 dimer interface [polypeptide binding]; other site 568815001310 conserved gate region; other site 568815001311 putative PBP binding loops; other site 568815001312 ABC-ATPase subunit interface; other site 568815001313 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 568815001314 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 568815001315 Walker A/P-loop; other site 568815001316 ATP binding site [chemical binding]; other site 568815001317 Q-loop/lid; other site 568815001318 ABC transporter signature motif; other site 568815001319 Walker B; other site 568815001320 D-loop; other site 568815001321 H-loop/switch region; other site 568815001322 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 568815001323 NMT1/THI5 like; Region: NMT1; pfam09084 568815001324 substrate binding pocket [chemical binding]; other site 568815001325 membrane-bound complex binding site; other site 568815001326 hinge residues; other site 568815001327 MarR family; Region: MarR_2; pfam12802 568815001328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568815001329 putative substrate translocation pore; other site 568815001330 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 568815001331 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 568815001332 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 568815001333 HlyD family secretion protein; Region: HlyD_3; pfam13437 568815001334 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568815001335 HAMP domain; Region: HAMP; pfam00672 568815001336 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568815001337 dimer interface [polypeptide binding]; other site 568815001338 phosphorylation site [posttranslational modification] 568815001339 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568815001340 ATP binding site [chemical binding]; other site 568815001341 Mg2+ binding site [ion binding]; other site 568815001342 G-X-G motif; other site 568815001343 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568815001344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568815001345 active site 568815001346 phosphorylation site [posttranslational modification] 568815001347 intermolecular recognition site; other site 568815001348 dimerization interface [polypeptide binding]; other site 568815001349 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568815001350 DNA binding site [nucleotide binding] 568815001351 Uncharacterized conserved protein [Function unknown]; Region: COG3189 568815001352 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 568815001353 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568815001354 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 568815001355 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 568815001356 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 568815001357 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 568815001358 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 568815001359 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 568815001360 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 568815001361 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 568815001362 Homoserine trans-succinylase [Amino acid transport and metabolism]; Region: MetA; COG1897 568815001363 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 568815001364 proposed active site lysine [active] 568815001365 conserved cys residue [active] 568815001366 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 568815001367 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 568815001368 active site 568815001369 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05963 568815001370 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 568815001371 dimer interface [polypeptide binding]; other site 568815001372 active site 568815001373 CoA binding pocket [chemical binding]; other site 568815001374 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 568815001375 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 568815001376 inhibitor-cofactor binding pocket; inhibition site 568815001377 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568815001378 catalytic residue [active] 568815001379 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 568815001380 AAA domain; Region: AAA_26; pfam13500 568815001381 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 568815001382 hypothetical protein; Provisional; Region: PRK07505 568815001383 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568815001384 catalytic residue [active] 568815001385 biotin synthase; Region: bioB; TIGR00433 568815001386 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568815001387 FeS/SAM binding site; other site 568815001388 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 568815001389 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 568815001390 MPT binding site; other site 568815001391 trimer interface [polypeptide binding]; other site 568815001392 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 568815001393 dimer interface [polypeptide binding]; other site 568815001394 FMN binding site [chemical binding]; other site 568815001395 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 568815001396 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 568815001397 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 568815001398 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 568815001399 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 568815001400 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 568815001401 monovalent cation:proton antiporter; Region: 2a6301s02; TIGR00943 568815001402 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 568815001403 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 568815001404 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 568815001405 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12596 568815001406 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 568815001407 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671 568815001408 Predicted transcriptional regulators [Transcription]; Region: COG1510 568815001409 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568815001410 dimerization interface [polypeptide binding]; other site 568815001411 putative DNA binding site [nucleotide binding]; other site 568815001412 putative Zn2+ binding site [ion binding]; other site 568815001413 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 568815001414 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568815001415 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 568815001416 Walker A/P-loop; other site 568815001417 ATP binding site [chemical binding]; other site 568815001418 Q-loop/lid; other site 568815001419 ABC transporter signature motif; other site 568815001420 Walker B; other site 568815001421 D-loop; other site 568815001422 H-loop/switch region; other site 568815001423 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 568815001424 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568815001425 Walker A/P-loop; other site 568815001426 ATP binding site [chemical binding]; other site 568815001427 Q-loop/lid; other site 568815001428 ABC transporter signature motif; other site 568815001429 Walker B; other site 568815001430 D-loop; other site 568815001431 H-loop/switch region; other site 568815001432 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 568815001433 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 568815001434 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 568815001435 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 568815001436 Predicted outer membrane lipoprotein [Function unknown]; Region: COG4890 568815001437 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568815001438 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568815001439 DNA-binding site [nucleotide binding]; DNA binding site 568815001440 UTRA domain; Region: UTRA; pfam07702 568815001441 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 568815001442 nucleotide binding site [chemical binding]; other site 568815001443 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 568815001444 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 568815001445 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 568815001446 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815001447 dimer interface [polypeptide binding]; other site 568815001448 conserved gate region; other site 568815001449 putative PBP binding loops; other site 568815001450 ABC-ATPase subunit interface; other site 568815001451 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 568815001452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815001453 dimer interface [polypeptide binding]; other site 568815001454 conserved gate region; other site 568815001455 putative PBP binding loops; other site 568815001456 ABC-ATPase subunit interface; other site 568815001457 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 568815001458 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 568815001459 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 568815001460 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 568815001461 Walker A/P-loop; other site 568815001462 ATP binding site [chemical binding]; other site 568815001463 Q-loop/lid; other site 568815001464 ABC transporter signature motif; other site 568815001465 Walker B; other site 568815001466 D-loop; other site 568815001467 H-loop/switch region; other site 568815001468 TOBE domain; Region: TOBE_2; pfam08402 568815001469 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 568815001470 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 568815001471 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 568815001472 tetramer interface [polypeptide binding]; other site 568815001473 TPP-binding site [chemical binding]; other site 568815001474 heterodimer interface [polypeptide binding]; other site 568815001475 phosphorylation loop region [posttranslational modification] 568815001476 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 568815001477 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 568815001478 alpha subunit interface [polypeptide binding]; other site 568815001479 TPP binding site [chemical binding]; other site 568815001480 heterodimer interface [polypeptide binding]; other site 568815001481 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 568815001482 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 568815001483 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 568815001484 E3 interaction surface; other site 568815001485 lipoyl attachment site [posttranslational modification]; other site 568815001486 e3 binding domain; Region: E3_binding; pfam02817 568815001487 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 568815001488 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 568815001489 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 568815001490 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568815001491 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 568815001492 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 568815001493 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 568815001494 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 568815001495 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 568815001496 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 568815001497 homodimer interface [polypeptide binding]; other site 568815001498 homotetramer interface [polypeptide binding]; other site 568815001499 active site pocket [active] 568815001500 cleavage site 568815001501 benzoate transport; Region: 2A0115; TIGR00895 568815001502 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568815001503 putative substrate translocation pore; other site 568815001504 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 568815001505 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 568815001506 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568815001507 Walker A/P-loop; other site 568815001508 ATP binding site [chemical binding]; other site 568815001509 Q-loop/lid; other site 568815001510 ABC transporter signature motif; other site 568815001511 Walker B; other site 568815001512 D-loop; other site 568815001513 H-loop/switch region; other site 568815001514 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 568815001515 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568815001516 Walker A/P-loop; other site 568815001517 ATP binding site [chemical binding]; other site 568815001518 Q-loop/lid; other site 568815001519 ABC transporter signature motif; other site 568815001520 Walker B; other site 568815001521 D-loop; other site 568815001522 H-loop/switch region; other site 568815001523 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568815001524 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 568815001525 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815001526 dimer interface [polypeptide binding]; other site 568815001527 conserved gate region; other site 568815001528 ABC-ATPase subunit interface; other site 568815001529 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 568815001530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815001531 dimer interface [polypeptide binding]; other site 568815001532 conserved gate region; other site 568815001533 putative PBP binding loops; other site 568815001534 ABC-ATPase subunit interface; other site 568815001535 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 568815001536 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 568815001537 peptide binding site [polypeptide binding]; other site 568815001538 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 568815001539 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 568815001540 peptide binding site [polypeptide binding]; other site 568815001541 Predicted integral membrane protein [Function unknown]; Region: COG5455 568815001542 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 568815001543 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 568815001544 NAD binding site [chemical binding]; other site 568815001545 putative substrate binding site 2 [chemical binding]; other site 568815001546 putative substrate binding site 1 [chemical binding]; other site 568815001547 active site 568815001548 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 568815001549 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 568815001550 NAD binding site [chemical binding]; other site 568815001551 homodimer interface [polypeptide binding]; other site 568815001552 active site 568815001553 substrate binding site [chemical binding]; other site 568815001554 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 568815001555 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 568815001556 active site 568815001557 Cellulose synthase-like protein; Region: PLN02893 568815001558 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 568815001559 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 568815001560 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 568815001561 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 568815001562 Protein of unknown function (DUF995); Region: DUF995; pfam06191 568815001563 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 568815001564 Protein of unknown function (DUF995); Region: DUF995; pfam06191 568815001565 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 568815001566 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568815001567 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 568815001568 yecA family protein; Region: ygfB_yecA; TIGR02292 568815001569 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 568815001570 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 568815001571 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 568815001572 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 568815001573 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 568815001574 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 568815001575 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 568815001576 Transposase; Region: HTH_Tnp_1; pfam01527 568815001577 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 568815001578 putative deacylase active site [active] 568815001579 iron-responsive transcriptional regulator; Reviewed; Region: rirA; PRK11920 568815001580 Predicted transcriptional regulator [Transcription]; Region: COG1959 568815001581 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 568815001582 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 568815001583 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 568815001584 heme binding site [chemical binding]; other site 568815001585 ferroxidase pore; other site 568815001586 ferroxidase diiron center [ion binding]; other site 568815001587 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 568815001588 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 568815001589 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568815001590 FeS/SAM binding site; other site 568815001591 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 568815001592 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 568815001593 putative ligand binding site [chemical binding]; other site 568815001594 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 568815001595 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568815001596 TM-ABC transporter signature motif; other site 568815001597 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568815001598 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 568815001599 TM-ABC transporter signature motif; other site 568815001600 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 568815001601 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 568815001602 Walker A/P-loop; other site 568815001603 ATP binding site [chemical binding]; other site 568815001604 Q-loop/lid; other site 568815001605 ABC transporter signature motif; other site 568815001606 Walker B; other site 568815001607 D-loop; other site 568815001608 H-loop/switch region; other site 568815001609 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 568815001610 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 568815001611 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 568815001612 NADP binding site [chemical binding]; other site 568815001613 dimer interface [polypeptide binding]; other site 568815001614 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 568815001615 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 568815001616 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494 568815001617 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 568815001618 Uncharacterized conserved protein [Function unknown]; Region: COG3785 568815001619 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 568815001620 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 568815001621 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 568815001622 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 568815001623 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 568815001624 catalytic residues [active] 568815001625 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 568815001626 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 568815001627 active site 568815001628 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 568815001629 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 568815001630 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568815001631 ATP binding site [chemical binding]; other site 568815001632 putative Mg++ binding site [ion binding]; other site 568815001633 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568815001634 nucleotide binding region [chemical binding]; other site 568815001635 ATP-binding site [chemical binding]; other site 568815001636 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 568815001637 Uncharacterized conserved protein [Function unknown]; Region: COG2938 568815001638 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 568815001639 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 568815001640 generic binding surface II; other site 568815001641 ssDNA binding site; other site 568815001642 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568815001643 ATP binding site [chemical binding]; other site 568815001644 putative Mg++ binding site [ion binding]; other site 568815001645 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568815001646 nucleotide binding region [chemical binding]; other site 568815001647 ATP-binding site [chemical binding]; other site 568815001648 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 568815001649 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 568815001650 glutaminase active site [active] 568815001651 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 568815001652 dimer interface [polypeptide binding]; other site 568815001653 active site 568815001654 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 568815001655 dimer interface [polypeptide binding]; other site 568815001656 active site 568815001657 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 568815001658 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 568815001659 Substrate binding site; other site 568815001660 Mg++ binding site; other site 568815001661 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 568815001662 active site 568815001663 substrate binding site [chemical binding]; other site 568815001664 CoA binding site [chemical binding]; other site 568815001665 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 568815001666 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 568815001667 Predicted integral membrane protein [Function unknown]; Region: COG0392 568815001668 Uncharacterized conserved protein [Function unknown]; Region: COG2898 568815001669 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 568815001670 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 568815001671 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 568815001672 BA14K-like protein; Region: BA14K; pfam07886 568815001673 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 568815001674 PAS domain; Region: PAS_9; pfam13426 568815001675 putative active site [active] 568815001676 heme pocket [chemical binding]; other site 568815001677 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 568815001678 PAS fold; Region: PAS_3; pfam08447 568815001679 putative active site [active] 568815001680 heme pocket [chemical binding]; other site 568815001681 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 568815001682 HWE histidine kinase; Region: HWE_HK; pfam07536 568815001683 lipoate-protein ligase B; Provisional; Region: PRK14341 568815001684 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 568815001685 EamA-like transporter family; Region: EamA; pfam00892 568815001686 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 568815001687 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568815001688 Mg2+ binding site [ion binding]; other site 568815001689 G-X-G motif; other site 568815001690 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 568815001691 anchoring element; other site 568815001692 dimer interface [polypeptide binding]; other site 568815001693 ATP binding site [chemical binding]; other site 568815001694 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 568815001695 active site 568815001696 metal binding site [ion binding]; metal-binding site 568815001697 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 568815001698 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 568815001699 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 568815001700 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 568815001701 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 568815001702 metal-dependent hydrolase; Provisional; Region: PRK00685 568815001703 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 568815001704 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 568815001705 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 568815001706 active site 568815001707 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 568815001708 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 568815001709 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 568815001710 dihydroorotase; Validated; Region: PRK09059 568815001711 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 568815001712 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 568815001713 active site 568815001714 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 568815001715 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 568815001716 DNA protecting protein DprA; Region: dprA; TIGR00732 568815001717 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 568815001718 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 568815001719 active site 568815001720 interdomain interaction site; other site 568815001721 putative metal-binding site [ion binding]; other site 568815001722 nucleotide binding site [chemical binding]; other site 568815001723 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 568815001724 domain I; other site 568815001725 DNA binding groove [nucleotide binding] 568815001726 phosphate binding site [ion binding]; other site 568815001727 domain II; other site 568815001728 domain III; other site 568815001729 nucleotide binding site [chemical binding]; other site 568815001730 catalytic site [active] 568815001731 domain IV; other site 568815001732 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 568815001733 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 568815001734 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 568815001735 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 568815001736 ribonuclease R; Region: RNase_R; TIGR02063 568815001737 RNB domain; Region: RNB; pfam00773 568815001738 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 568815001739 RNA binding site [nucleotide binding]; other site 568815001740 hypothetical protein; Provisional; Region: PRK05978 568815001741 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568815001742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568815001743 putative substrate translocation pore; other site 568815001744 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 568815001745 response regulator PleD; Reviewed; Region: pleD; PRK09581 568815001746 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568815001747 active site 568815001748 phosphorylation site [posttranslational modification] 568815001749 intermolecular recognition site; other site 568815001750 dimerization interface [polypeptide binding]; other site 568815001751 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568815001752 active site 568815001753 phosphorylation site [posttranslational modification] 568815001754 intermolecular recognition site; other site 568815001755 dimerization interface [polypeptide binding]; other site 568815001756 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 568815001757 metal binding site [ion binding]; metal-binding site 568815001758 active site 568815001759 I-site; other site 568815001760 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 568815001761 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568815001762 active site 568815001763 phosphorylation site [posttranslational modification] 568815001764 intermolecular recognition site; other site 568815001765 dimerization interface [polypeptide binding]; other site 568815001766 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 568815001767 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 568815001768 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 568815001769 DNA polymerase IV; Provisional; Region: PRK02794 568815001770 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 568815001771 active site 568815001772 DNA binding site [nucleotide binding] 568815001773 Uncharacterized conserved protein [Function unknown]; Region: COG3391 568815001774 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 568815001775 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 568815001776 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 568815001777 metal binding site [ion binding]; metal-binding site 568815001778 active site 568815001779 I-site; other site 568815001780 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 568815001781 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 568815001782 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 568815001783 active site 568815001784 catalytic site [active] 568815001785 substrate binding site [chemical binding]; other site 568815001786 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568815001787 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 568815001788 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568815001789 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 568815001790 hydroxyglutarate oxidase; Provisional; Region: PRK11728 568815001791 hydroxyglutarate oxidase; Provisional; Region: PRK11728 568815001792 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568815001793 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568815001794 substrate binding pocket [chemical binding]; other site 568815001795 membrane-bound complex binding site; other site 568815001796 hinge residues; other site 568815001797 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568815001798 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568815001799 substrate binding pocket [chemical binding]; other site 568815001800 membrane-bound complex binding site; other site 568815001801 hinge residues; other site 568815001802 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 568815001803 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568815001804 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568815001805 putative DNA binding site [nucleotide binding]; other site 568815001806 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 568815001807 putative Zn2+ binding site [ion binding]; other site 568815001808 AsnC family; Region: AsnC_trans_reg; pfam01037 568815001809 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 568815001810 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 568815001811 active site 568815001812 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 568815001813 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 568815001814 dimer interface [polypeptide binding]; other site 568815001815 active site 568815001816 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 568815001817 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 568815001818 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 568815001819 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 568815001820 Bacterial transcriptional regulator; Region: IclR; pfam01614 568815001821 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 568815001822 Cupin domain; Region: Cupin_2; cl17218 568815001823 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568815001824 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 568815001825 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 568815001826 hypothetical protein; Provisional; Region: PRK07236 568815001827 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 568815001828 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568815001829 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568815001830 dimerization interface [polypeptide binding]; other site 568815001831 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 568815001832 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 568815001833 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 568815001834 heterodimer interface [polypeptide binding]; other site 568815001835 active site 568815001836 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK05975 568815001837 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 568815001838 tetramer interface [polypeptide binding]; other site 568815001839 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568815001840 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 568815001841 TM-ABC transporter signature motif; other site 568815001842 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 568815001843 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 568815001844 TM-ABC transporter signature motif; other site 568815001845 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 568815001846 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 568815001847 Walker A/P-loop; other site 568815001848 ATP binding site [chemical binding]; other site 568815001849 Q-loop/lid; other site 568815001850 ABC transporter signature motif; other site 568815001851 Walker B; other site 568815001852 D-loop; other site 568815001853 H-loop/switch region; other site 568815001854 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 568815001855 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 568815001856 Walker A/P-loop; other site 568815001857 ATP binding site [chemical binding]; other site 568815001858 Q-loop/lid; other site 568815001859 ABC transporter signature motif; other site 568815001860 Walker B; other site 568815001861 D-loop; other site 568815001862 H-loop/switch region; other site 568815001863 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 568815001864 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 568815001865 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 568815001866 active site 568815001867 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 568815001868 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 568815001869 active site 568815001870 dimer interface [polypeptide binding]; other site 568815001871 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 568815001872 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 568815001873 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 568815001874 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 568815001875 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 568815001876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815001877 dimer interface [polypeptide binding]; other site 568815001878 conserved gate region; other site 568815001879 ABC-ATPase subunit interface; other site 568815001880 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 568815001881 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 568815001882 Walker A/P-loop; other site 568815001883 ATP binding site [chemical binding]; other site 568815001884 Q-loop/lid; other site 568815001885 ABC transporter signature motif; other site 568815001886 Walker B; other site 568815001887 D-loop; other site 568815001888 H-loop/switch region; other site 568815001889 TOBE domain; Region: TOBE_2; pfam08402 568815001890 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 568815001891 nucleoside/Zn binding site; other site 568815001892 dimer interface [polypeptide binding]; other site 568815001893 catalytic motif [active] 568815001894 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 568815001895 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 568815001896 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 568815001897 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 568815001898 EamA-like transporter family; Region: EamA; pfam00892 568815001899 aminotransferase; Provisional; Region: PRK13356 568815001900 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 568815001901 homodimer interface [polypeptide binding]; other site 568815001902 substrate-cofactor binding pocket; other site 568815001903 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568815001904 catalytic residue [active] 568815001905 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 568815001906 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 568815001907 FAD binding domain; Region: FAD_binding_2; pfam00890 568815001908 Protein of unknown function (DUF3775); Region: DUF3775; pfam12616 568815001909 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 568815001910 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 568815001911 NAD binding site [chemical binding]; other site 568815001912 catalytic residues [active] 568815001913 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 568815001914 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 568815001915 putative ligand binding residues [chemical binding]; other site 568815001916 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 568815001917 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 568815001918 ABC-ATPase subunit interface; other site 568815001919 dimer interface [polypeptide binding]; other site 568815001920 putative PBP binding regions; other site 568815001921 ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism]; Region: CeuC; COG4605 568815001922 ABC-ATPase subunit interface; other site 568815001923 dimer interface [polypeptide binding]; other site 568815001924 putative PBP binding regions; other site 568815001925 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 568815001926 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 568815001927 Walker A/P-loop; other site 568815001928 ATP binding site [chemical binding]; other site 568815001929 Q-loop/lid; other site 568815001930 ABC transporter signature motif; other site 568815001931 Walker B; other site 568815001932 D-loop; other site 568815001933 H-loop/switch region; other site 568815001934 Predicted transcription regulator, contains HTH domain (MarR family) [Transcription]; Region: COG5631 568815001935 5-oxoprolinase; Region: PLN02666 568815001936 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 568815001937 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 568815001938 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 568815001939 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568815001940 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568815001941 substrate binding pocket [chemical binding]; other site 568815001942 membrane-bound complex binding site; other site 568815001943 hinge residues; other site 568815001944 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815001945 dimer interface [polypeptide binding]; other site 568815001946 conserved gate region; other site 568815001947 putative PBP binding loops; other site 568815001948 ABC-ATPase subunit interface; other site 568815001949 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 568815001950 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568815001951 Walker A/P-loop; other site 568815001952 ATP binding site [chemical binding]; other site 568815001953 Q-loop/lid; other site 568815001954 ABC transporter signature motif; other site 568815001955 Walker B; other site 568815001956 D-loop; other site 568815001957 H-loop/switch region; other site 568815001958 exopolyphosphatase; Region: exo_poly_only; TIGR03706 568815001959 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 568815001960 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 568815001961 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568815001962 S-adenosylmethionine binding site [chemical binding]; other site 568815001963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568815001964 putative transporter; Provisional; Region: PRK10504 568815001965 putative substrate translocation pore; other site 568815001966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568815001967 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 568815001968 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 568815001969 Walker A/P-loop; other site 568815001970 ATP binding site [chemical binding]; other site 568815001971 Q-loop/lid; other site 568815001972 ABC transporter signature motif; other site 568815001973 Walker B; other site 568815001974 D-loop; other site 568815001975 H-loop/switch region; other site 568815001976 TOBE domain; Region: TOBE_2; pfam08402 568815001977 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 568815001978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815001979 dimer interface [polypeptide binding]; other site 568815001980 conserved gate region; other site 568815001981 putative PBP binding loops; other site 568815001982 ABC-ATPase subunit interface; other site 568815001983 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815001984 dimer interface [polypeptide binding]; other site 568815001985 conserved gate region; other site 568815001986 putative PBP binding loops; other site 568815001987 ABC-ATPase subunit interface; other site 568815001988 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 568815001989 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 568815001990 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-II; Region: Lumazine_synthase-II; cd09208 568815001991 active site 568815001992 homopentamer interface [polypeptide binding]; other site 568815001993 dimer interface [polypeptide binding]; other site 568815001994 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 568815001995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3453 568815001996 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 568815001997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815001998 dimer interface [polypeptide binding]; other site 568815001999 conserved gate region; other site 568815002000 putative PBP binding loops; other site 568815002001 ABC-ATPase subunit interface; other site 568815002002 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815002003 dimer interface [polypeptide binding]; other site 568815002004 conserved gate region; other site 568815002005 putative PBP binding loops; other site 568815002006 ABC-ATPase subunit interface; other site 568815002007 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 568815002008 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 568815002009 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 568815002010 hydroxyglutarate oxidase; Provisional; Region: PRK11728 568815002011 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 568815002012 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 568815002013 E-class dimer interface [polypeptide binding]; other site 568815002014 P-class dimer interface [polypeptide binding]; other site 568815002015 active site 568815002016 Cu2+ binding site [ion binding]; other site 568815002017 Zn2+ binding site [ion binding]; other site 568815002018 multicopper oxidase; Provisional; Region: PRK10965 568815002019 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 568815002020 Multicopper oxidase; Region: Cu-oxidase; pfam00394 568815002021 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 568815002022 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568815002023 metabolite-proton symporter; Region: 2A0106; TIGR00883 568815002024 putative substrate translocation pore; other site 568815002025 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 568815002026 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 568815002027 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 568815002028 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 568815002029 dimer interface [polypeptide binding]; other site 568815002030 decamer (pentamer of dimers) interface [polypeptide binding]; other site 568815002031 catalytic triad [active] 568815002032 peroxidatic and resolving cysteines [active] 568815002033 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 568815002034 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568815002035 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 568815002036 dimerization interface [polypeptide binding]; other site 568815002037 Protein of unknown function (DUF1612); Region: DUF1612; pfam07756 568815002038 HTH DNA binding domain; Region: HTH_13; pfam11972 568815002039 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 568815002040 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 568815002041 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 568815002042 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 568815002043 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 568815002044 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 568815002045 putative active site [active] 568815002046 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 568815002047 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 568815002048 PYR/PP interface [polypeptide binding]; other site 568815002049 dimer interface [polypeptide binding]; other site 568815002050 TPP binding site [chemical binding]; other site 568815002051 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 568815002052 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 568815002053 TPP-binding site [chemical binding]; other site 568815002054 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 568815002055 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 568815002056 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 568815002057 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568815002058 Walker A/P-loop; other site 568815002059 ATP binding site [chemical binding]; other site 568815002060 Q-loop/lid; other site 568815002061 ABC transporter signature motif; other site 568815002062 Walker B; other site 568815002063 D-loop; other site 568815002064 H-loop/switch region; other site 568815002065 TOBE domain; Region: TOBE_2; pfam08402 568815002066 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 568815002067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815002068 dimer interface [polypeptide binding]; other site 568815002069 conserved gate region; other site 568815002070 putative PBP binding loops; other site 568815002071 ABC-ATPase subunit interface; other site 568815002072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815002073 dimer interface [polypeptide binding]; other site 568815002074 conserved gate region; other site 568815002075 putative PBP binding loops; other site 568815002076 ABC-ATPase subunit interface; other site 568815002077 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 568815002078 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 568815002079 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 568815002080 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 568815002081 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 568815002082 Glutamate binding site [chemical binding]; other site 568815002083 NAD binding site [chemical binding]; other site 568815002084 catalytic residues [active] 568815002085 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 568815002086 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568815002087 putative DNA binding site [nucleotide binding]; other site 568815002088 putative Zn2+ binding site [ion binding]; other site 568815002089 AsnC family; Region: AsnC_trans_reg; pfam01037 568815002090 glycine dehydrogenase; Provisional; Region: PRK05367 568815002091 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 568815002092 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568815002093 catalytic residue [active] 568815002094 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 568815002095 tetramer interface [polypeptide binding]; other site 568815002096 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568815002097 catalytic residue [active] 568815002098 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 568815002099 lipoyl attachment site [posttranslational modification]; other site 568815002100 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 568815002101 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 568815002102 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 568815002103 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 568815002104 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 568815002105 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568815002106 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 568815002107 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 568815002108 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 568815002109 putative active site [active] 568815002110 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 568815002111 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 568815002112 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 568815002113 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 568815002114 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 568815002115 putative active site [active] 568815002116 metal binding site [ion binding]; metal-binding site 568815002117 BA14K-like protein; Region: BA14K; pfam07886 568815002118 EamA-like transporter family; Region: EamA; pfam00892 568815002119 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 568815002120 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 568815002121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815002122 dimer interface [polypeptide binding]; other site 568815002123 conserved gate region; other site 568815002124 putative PBP binding loops; other site 568815002125 ABC-ATPase subunit interface; other site 568815002126 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 568815002127 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 568815002128 Walker A/P-loop; other site 568815002129 ATP binding site [chemical binding]; other site 568815002130 Q-loop/lid; other site 568815002131 ABC transporter signature motif; other site 568815002132 Walker B; other site 568815002133 D-loop; other site 568815002134 H-loop/switch region; other site 568815002135 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 568815002136 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 568815002137 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 568815002138 dimer interface [polypeptide binding]; other site 568815002139 active site 568815002140 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 568815002141 substrate binding site [chemical binding]; other site 568815002142 catalytic residue [active] 568815002143 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 568815002144 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 568815002145 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 568815002146 putative active site [active] 568815002147 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 568815002148 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 568815002149 Walker A/P-loop; other site 568815002150 ATP binding site [chemical binding]; other site 568815002151 Q-loop/lid; other site 568815002152 ABC transporter signature motif; other site 568815002153 Walker B; other site 568815002154 D-loop; other site 568815002155 H-loop/switch region; other site 568815002156 TOBE domain; Region: TOBE; pfam03459 568815002157 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 568815002158 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568815002159 NAD(P) binding site [chemical binding]; other site 568815002160 active site 568815002161 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 568815002162 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 568815002163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815002164 dimer interface [polypeptide binding]; other site 568815002165 conserved gate region; other site 568815002166 putative PBP binding loops; other site 568815002167 ABC-ATPase subunit interface; other site 568815002168 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 568815002169 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815002170 dimer interface [polypeptide binding]; other site 568815002171 conserved gate region; other site 568815002172 putative PBP binding loops; other site 568815002173 ABC-ATPase subunit interface; other site 568815002174 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 568815002175 homotrimer interaction site [polypeptide binding]; other site 568815002176 putative active site [active] 568815002177 Uncharacterized conserved protein [Function unknown]; Region: COG5476 568815002178 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 568815002179 MlrC C-terminus; Region: MlrC_C; pfam07171 568815002180 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 568815002181 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 568815002182 Walker A/P-loop; other site 568815002183 ATP binding site [chemical binding]; other site 568815002184 Q-loop/lid; other site 568815002185 ABC transporter signature motif; other site 568815002186 Walker B; other site 568815002187 D-loop; other site 568815002188 H-loop/switch region; other site 568815002189 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 568815002190 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 568815002191 ABC-ATPase subunit interface; other site 568815002192 dimer interface [polypeptide binding]; other site 568815002193 putative PBP binding regions; other site 568815002194 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 568815002195 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 568815002196 putative ligand binding residues [chemical binding]; other site 568815002197 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 568815002198 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 568815002199 HlyD family secretion protein; Region: HlyD_3; pfam13437 568815002200 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 568815002201 Fusaric acid resistance protein family; Region: FUSC; pfam04632 568815002202 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 568815002203 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 568815002204 MarR family; Region: MarR_2; pfam12802 568815002205 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 568815002206 RNA methyltransferase, RsmE family; Region: TIGR00046 568815002207 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 568815002208 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 568815002209 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 568815002210 generic binding surface II; other site 568815002211 generic binding surface I; other site 568815002212 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568815002213 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568815002214 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568815002215 dimerization interface [polypeptide binding]; other site 568815002216 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 568815002217 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 568815002218 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 568815002219 hypothetical protein; Reviewed; Region: PRK12275 568815002220 four helix bundle protein; Region: TIGR02436 568815002221 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 568815002222 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 568815002223 Transcriptional regulators [Transcription]; Region: MarR; COG1846 568815002224 Hint domain; Region: Hint_2; pfam13403 568815002225 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 568815002226 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568815002227 putative DNA binding site [nucleotide binding]; other site 568815002228 putative Zn2+ binding site [ion binding]; other site 568815002229 AsnC family; Region: AsnC_trans_reg; pfam01037 568815002230 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 568815002231 Predicted membrane protein [Function unknown]; Region: COG4541 568815002232 drug efflux system protein MdtG; Provisional; Region: PRK09874 568815002233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568815002234 putative substrate translocation pore; other site 568815002235 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345 568815002236 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 568815002237 putative NAD(P) binding site [chemical binding]; other site 568815002238 active site 568815002239 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 568815002240 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 568815002241 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 568815002242 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 568815002243 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 568815002244 putative active site [active] 568815002245 phosphogluconate dehydratase; Validated; Region: PRK09054 568815002246 6-phosphogluconate dehydratase; Region: edd; TIGR01196 568815002247 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 568815002248 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 568815002249 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 568815002250 homodimer interface [polypeptide binding]; other site 568815002251 NADP binding site [chemical binding]; other site 568815002252 substrate binding site [chemical binding]; other site 568815002253 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 568815002254 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 568815002255 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 568815002256 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568815002257 Walker A/P-loop; other site 568815002258 ATP binding site [chemical binding]; other site 568815002259 Q-loop/lid; other site 568815002260 ABC transporter signature motif; other site 568815002261 Walker B; other site 568815002262 D-loop; other site 568815002263 H-loop/switch region; other site 568815002264 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568815002265 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 568815002266 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568815002267 Walker A/P-loop; other site 568815002268 ATP binding site [chemical binding]; other site 568815002269 Q-loop/lid; other site 568815002270 ABC transporter signature motif; other site 568815002271 Walker B; other site 568815002272 D-loop; other site 568815002273 H-loop/switch region; other site 568815002274 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 568815002275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815002276 dimer interface [polypeptide binding]; other site 568815002277 conserved gate region; other site 568815002278 putative PBP binding loops; other site 568815002279 ABC-ATPase subunit interface; other site 568815002280 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 568815002281 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815002282 dimer interface [polypeptide binding]; other site 568815002283 conserved gate region; other site 568815002284 putative PBP binding loops; other site 568815002285 ABC-ATPase subunit interface; other site 568815002286 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 568815002287 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 568815002288 Eukaryotic translation initiation factor 3 subunit 8 N-terminus; Region: eIF-3c_N; pfam05470 568815002289 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 568815002290 active site clefts [active] 568815002291 zinc binding site [ion binding]; other site 568815002292 dimer interface [polypeptide binding]; other site 568815002293 tellurite resistance protein terB; Region: terB; cd07176 568815002294 putative metal binding site [ion binding]; other site 568815002295 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 568815002296 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 568815002297 active site 568815002298 nucleotide binding site [chemical binding]; other site 568815002299 HIGH motif; other site 568815002300 KMSKS motif; other site 568815002301 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 568815002302 Predicted transcriptional regulator [Transcription]; Region: COG2932 568815002303 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 568815002304 Catalytic site [active] 568815002305 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 568815002306 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568815002307 substrate binding site [chemical binding]; other site 568815002308 oxyanion hole (OAH) forming residues; other site 568815002309 trimer interface [polypeptide binding]; other site 568815002310 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 568815002311 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 568815002312 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 568815002313 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 568815002314 dimer interface [polypeptide binding]; other site 568815002315 active site 568815002316 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 568815002317 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 568815002318 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 568815002319 FAD binding site [chemical binding]; other site 568815002320 substrate binding site [chemical binding]; other site 568815002321 catalytic residues [active] 568815002322 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 568815002323 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568815002324 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568815002325 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 568815002326 putative dimerization interface [polypeptide binding]; other site 568815002327 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 568815002328 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 568815002329 active site 568815002330 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 568815002331 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568815002332 Walker A/P-loop; other site 568815002333 ATP binding site [chemical binding]; other site 568815002334 Q-loop/lid; other site 568815002335 ABC transporter signature motif; other site 568815002336 Walker B; other site 568815002337 D-loop; other site 568815002338 H-loop/switch region; other site 568815002339 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 568815002340 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568815002341 Walker A/P-loop; other site 568815002342 ATP binding site [chemical binding]; other site 568815002343 Q-loop/lid; other site 568815002344 ABC transporter signature motif; other site 568815002345 Walker B; other site 568815002346 D-loop; other site 568815002347 H-loop/switch region; other site 568815002348 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 568815002349 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815002350 dimer interface [polypeptide binding]; other site 568815002351 conserved gate region; other site 568815002352 putative PBP binding loops; other site 568815002353 ABC-ATPase subunit interface; other site 568815002354 nickel transporter permease NikB; Provisional; Region: PRK10352 568815002355 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815002356 dimer interface [polypeptide binding]; other site 568815002357 conserved gate region; other site 568815002358 putative PBP binding loops; other site 568815002359 ABC-ATPase subunit interface; other site 568815002360 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 568815002361 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 568815002362 substrate binding site [chemical binding]; other site 568815002363 nickel responsive regulator; Provisional; Region: PRK02967 568815002364 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 568815002365 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 568815002366 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 568815002367 galactarate dehydratase; Region: galactar-dH20; TIGR03248 568815002368 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 568815002369 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 568815002370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815002371 dimer interface [polypeptide binding]; other site 568815002372 conserved gate region; other site 568815002373 putative PBP binding loops; other site 568815002374 ABC-ATPase subunit interface; other site 568815002375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815002376 putative PBP binding loops; other site 568815002377 ABC-ATPase subunit interface; other site 568815002378 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 568815002379 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568815002380 Walker A/P-loop; other site 568815002381 ATP binding site [chemical binding]; other site 568815002382 Q-loop/lid; other site 568815002383 ABC transporter signature motif; other site 568815002384 Walker B; other site 568815002385 D-loop; other site 568815002386 H-loop/switch region; other site 568815002387 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 568815002388 hypothetical protein; Provisional; Region: PRK11622 568815002389 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 568815002390 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 568815002391 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 568815002392 glucuronate isomerase; Reviewed; Region: PRK02925 568815002393 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 568815002394 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568815002395 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568815002396 DNA-binding site [nucleotide binding]; DNA binding site 568815002397 FCD domain; Region: FCD; pfam07729 568815002398 mannonate dehydratase; Region: uxuA; TIGR00695 568815002399 mannonate dehydratase; Provisional; Region: PRK03906 568815002400 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 568815002401 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 568815002402 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 568815002403 HlyD family secretion protein; Region: HlyD_3; pfam13437 568815002404 camphor resistance protein CrcB; Provisional; Region: PRK14233 568815002405 camphor resistance protein CrcB; Provisional; Region: PRK14225 568815002406 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 568815002407 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 568815002408 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 568815002409 DNA binding residues [nucleotide binding] 568815002410 putative dimer interface [polypeptide binding]; other site 568815002411 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 568815002412 Sel1-like repeats; Region: SEL1; smart00671 568815002413 Sel1-like repeats; Region: SEL1; smart00671 568815002414 Sel1-like repeats; Region: SEL1; smart00671 568815002415 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 568815002416 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 568815002417 conserved hypothetical protein; Region: alph_Pro_TM; TIGR02186 568815002418 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 568815002419 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 568815002420 putative active site [active] 568815002421 putative metal binding site [ion binding]; other site 568815002422 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 568815002423 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568815002424 ATP binding site [chemical binding]; other site 568815002425 putative Mg++ binding site [ion binding]; other site 568815002426 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568815002427 nucleotide binding region [chemical binding]; other site 568815002428 ATP-binding site [chemical binding]; other site 568815002429 DEAD/H associated; Region: DEAD_assoc; pfam08494 568815002430 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 568815002431 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 568815002432 FMN binding site [chemical binding]; other site 568815002433 substrate binding site [chemical binding]; other site 568815002434 putative catalytic residue [active] 568815002435 Uncharacterized phage-associated protein [Function unknown]; Region: GepA; COG3600 568815002436 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 568815002437 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 568815002438 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 568815002439 HsdM N-terminal domain; Region: HsdM_N; pfam12161 568815002440 Methyltransferase domain; Region: Methyltransf_26; pfam13659 568815002441 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 568815002442 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 568815002443 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 568815002444 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568815002445 ATP binding site [chemical binding]; other site 568815002446 putative Mg++ binding site [ion binding]; other site 568815002447 helicase superfamily c-terminal domain; Region: HELICc; smart00490 568815002448 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 568815002449 Protein of unknown function DUF45; Region: DUF45; pfam01863 568815002450 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 568815002451 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 568815002452 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568815002453 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 568815002454 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 568815002455 inhibitor-cofactor binding pocket; inhibition site 568815002456 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568815002457 catalytic residue [active] 568815002458 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 568815002459 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568815002460 NAD(P) binding site [chemical binding]; other site 568815002461 active site 568815002462 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 568815002463 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 568815002464 FAD binding domain; Region: FAD_binding_4; pfam01565 568815002465 hypothetical protein; Validated; Region: PRK08238 568815002466 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 568815002467 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 568815002468 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 568815002469 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 568815002470 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 568815002471 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 568815002472 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 568815002473 ligand binding site [chemical binding]; other site 568815002474 dimerization interface [polypeptide binding]; other site 568815002475 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 568815002476 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568815002477 TM-ABC transporter signature motif; other site 568815002478 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 568815002479 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 568815002480 Walker A/P-loop; other site 568815002481 ATP binding site [chemical binding]; other site 568815002482 Q-loop/lid; other site 568815002483 ABC transporter signature motif; other site 568815002484 Walker B; other site 568815002485 D-loop; other site 568815002486 H-loop/switch region; other site 568815002487 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 568815002488 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; pfam10054 568815002489 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 568815002490 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 568815002491 putative N- and C-terminal domain interface [polypeptide binding]; other site 568815002492 putative active site [active] 568815002493 MgATP binding site [chemical binding]; other site 568815002494 catalytic site [active] 568815002495 metal binding site [ion binding]; metal-binding site 568815002496 putative xylulose binding site [chemical binding]; other site 568815002497 glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369 568815002498 hydroxyglutarate oxidase; Provisional; Region: PRK11728 568815002499 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 568815002500 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 568815002501 PCI domain; Region: PCI; cl02111 568815002502 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 568815002503 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 568815002504 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 568815002505 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 568815002506 triosephosphate isomerase; Provisional; Region: PRK14565 568815002507 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 568815002508 substrate binding site [chemical binding]; other site 568815002509 dimer interface [polypeptide binding]; other site 568815002510 catalytic triad [active] 568815002511 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 568815002512 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 568815002513 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 568815002514 intersubunit interface [polypeptide binding]; other site 568815002515 active site 568815002516 zinc binding site [ion binding]; other site 568815002517 Na+ binding site [ion binding]; other site 568815002518 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 568815002519 AMP binding site [chemical binding]; other site 568815002520 metal binding site [ion binding]; metal-binding site 568815002521 active site 568815002522 Uncharacterized conserved protein [Function unknown]; Region: COG1739 568815002523 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 568815002524 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 568815002525 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 568815002526 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 568815002527 G1 box; other site 568815002528 putative GEF interaction site [polypeptide binding]; other site 568815002529 GTP/Mg2+ binding site [chemical binding]; other site 568815002530 Switch I region; other site 568815002531 G2 box; other site 568815002532 G3 box; other site 568815002533 Switch II region; other site 568815002534 G4 box; other site 568815002535 G5 box; other site 568815002536 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 568815002537 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 568815002538 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 568815002539 MgtE intracellular N domain; Region: MgtE_N; pfam03448 568815002540 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 568815002541 Divalent cation transporter; Region: MgtE; pfam01769 568815002542 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 568815002543 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 568815002544 active site 568815002545 Zn binding site [ion binding]; other site 568815002546 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 568815002547 dimer interface [polypeptide binding]; other site 568815002548 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 568815002549 Uncharacterized conserved small protein [Function unknown]; Region: COG5515 568815002550 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 568815002551 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 568815002552 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 568815002553 substrate binding site [chemical binding]; other site 568815002554 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 568815002555 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 568815002556 Transcriptional regulators [Transcription]; Region: MarR; COG1846 568815002557 MarR family; Region: MarR; pfam01047 568815002558 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 568815002559 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 568815002560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568815002561 putative substrate translocation pore; other site 568815002562 tartrate dehydrogenase; Region: TTC; TIGR02089 568815002563 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 568815002564 Uncharacterized conserved protein [Function unknown]; Region: COG2835 568815002565 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 568815002566 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 568815002567 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 568815002568 catalytic residues [active] 568815002569 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 568815002570 putative deacylase active site [active] 568815002571 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 568815002572 apolar tunnel; other site 568815002573 heme binding site [chemical binding]; other site 568815002574 dimerization interface [polypeptide binding]; other site 568815002575 ornithine cyclodeaminase; Validated; Region: PRK07589 568815002576 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 568815002577 Arginase family; Region: Arginase; cd09989 568815002578 agmatinase; Region: agmatinase; TIGR01230 568815002579 active site 568815002580 Mn binding site [ion binding]; other site 568815002581 oligomer interface [polypeptide binding]; other site 568815002582 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 568815002583 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 568815002584 AsnC family; Region: AsnC_trans_reg; pfam01037 568815002585 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 568815002586 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 568815002587 FMN binding site [chemical binding]; other site 568815002588 active site 568815002589 substrate binding site [chemical binding]; other site 568815002590 catalytic residue [active] 568815002591 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568815002592 dimerization interface [polypeptide binding]; other site 568815002593 putative DNA binding site [nucleotide binding]; other site 568815002594 putative Zn2+ binding site [ion binding]; other site 568815002595 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 568815002596 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 568815002597 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 568815002598 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 568815002599 RNA binding site [nucleotide binding]; other site 568815002600 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 568815002601 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 568815002602 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 568815002603 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568815002604 putative Zn2+ binding site [ion binding]; other site 568815002605 putative DNA binding site [nucleotide binding]; other site 568815002606 dimerization interface [polypeptide binding]; other site 568815002607 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568815002608 dimerization interface [polypeptide binding]; other site 568815002609 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 568815002610 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 568815002611 aldehyde dehydrogenase family 7 member; Region: PLN02315 568815002612 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 568815002613 tetrameric interface [polypeptide binding]; other site 568815002614 NAD binding site [chemical binding]; other site 568815002615 catalytic residues [active] 568815002616 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 568815002617 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 568815002618 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 568815002619 putative active site [active] 568815002620 putative substrate binding site [chemical binding]; other site 568815002621 putative cosubstrate binding site; other site 568815002622 catalytic site [active] 568815002623 hypothetical protein; Provisional; Region: PRK02947 568815002624 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 568815002625 putative active site [active] 568815002626 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 568815002627 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 568815002628 active site 568815002629 dimer interface [polypeptide binding]; other site 568815002630 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 568815002631 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 568815002632 dimer interface [polypeptide binding]; other site 568815002633 active site 568815002634 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 568815002635 dimer interface [polypeptide binding]; other site 568815002636 active site 568815002637 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568815002638 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568815002639 DNA-binding site [nucleotide binding]; DNA binding site 568815002640 UTRA domain; Region: UTRA; pfam07702 568815002641 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 568815002642 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 568815002643 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 568815002644 HlyD family secretion protein; Region: HlyD_3; pfam13437 568815002645 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 568815002646 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 568815002647 HlyD family secretion protein; Region: HlyD_3; pfam13437 568815002648 putative membrane fusion protein; Region: TIGR02828 568815002649 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 568815002650 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 568815002651 putative molybdopterin cofactor binding site [chemical binding]; other site 568815002652 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 568815002653 putative molybdopterin cofactor binding site; other site 568815002654 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 568815002655 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 568815002656 phosphate binding site [ion binding]; other site 568815002657 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 568815002658 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 568815002659 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568815002660 putative DNA binding site [nucleotide binding]; other site 568815002661 putative Zn2+ binding site [ion binding]; other site 568815002662 AsnC family; Region: AsnC_trans_reg; pfam01037 568815002663 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 568815002664 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 568815002665 active site 568815002666 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 568815002667 dimer interface [polypeptide binding]; other site 568815002668 substrate binding site [chemical binding]; other site 568815002669 catalytic residues [active] 568815002670 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 568815002671 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568815002672 hydroxyglutarate oxidase; Provisional; Region: PRK11728 568815002673 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 568815002674 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568815002675 non-specific DNA binding site [nucleotide binding]; other site 568815002676 salt bridge; other site 568815002677 sequence-specific DNA binding site [nucleotide binding]; other site 568815002678 Cupin domain; Region: Cupin_2; pfam07883 568815002679 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 568815002680 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 568815002681 inhibitor-cofactor binding pocket; inhibition site 568815002682 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568815002683 catalytic residue [active] 568815002684 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 568815002685 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568815002686 DNA-binding site [nucleotide binding]; DNA binding site 568815002687 UTRA domain; Region: UTRA; pfam07702 568815002688 formiminoglutamate deiminase; Region: hutF; TIGR02022 568815002689 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 568815002690 active site 568815002691 imidazolonepropionase; Validated; Region: PRK09356 568815002692 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 568815002693 active site 568815002694 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 568815002695 active sites [active] 568815002696 tetramer interface [polypeptide binding]; other site 568815002697 N-formylglutamate amidohydrolase; Region: hutG_amidohyd; TIGR02017 568815002698 urocanate hydratase; Provisional; Region: PRK05414 568815002699 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3758 568815002700 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 568815002701 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 568815002702 homodimer interface [polypeptide binding]; other site 568815002703 substrate-cofactor binding pocket; other site 568815002704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568815002705 catalytic residue [active] 568815002706 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 568815002707 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 568815002708 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568815002709 TM-ABC transporter signature motif; other site 568815002710 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 568815002711 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 568815002712 Walker A/P-loop; other site 568815002713 ATP binding site [chemical binding]; other site 568815002714 Q-loop/lid; other site 568815002715 ABC transporter signature motif; other site 568815002716 Walker B; other site 568815002717 D-loop; other site 568815002718 H-loop/switch region; other site 568815002719 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 568815002720 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 568815002721 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 568815002722 putative ligand binding site [chemical binding]; other site 568815002723 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 568815002724 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 568815002725 active site 568815002726 intersubunit interface [polypeptide binding]; other site 568815002727 catalytic residue [active] 568815002728 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 568815002729 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 568815002730 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 568815002731 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 568815002732 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 568815002733 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 568815002734 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 568815002735 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 568815002736 Transcriptional regulators [Transcription]; Region: FadR; COG2186 568815002737 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568815002738 DNA-binding site [nucleotide binding]; DNA binding site 568815002739 FCD domain; Region: FCD; pfam07729 568815002740 thiamine pyrophosphate protein; Validated; Region: PRK08199 568815002741 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 568815002742 PYR/PP interface [polypeptide binding]; other site 568815002743 dimer interface [polypeptide binding]; other site 568815002744 TPP binding site [chemical binding]; other site 568815002745 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 568815002746 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 568815002747 TPP-binding site [chemical binding]; other site 568815002748 D-aminopeptidase; Reviewed; Region: PRK13128 568815002749 Beta-lactamase; Region: Beta-lactamase; pfam00144 568815002750 D-aminopeptidase, domain B; Region: DAP_B; pfam07930 568815002751 D-aminopeptidase, domain C; Region: DAP_C; pfam07932 568815002752 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 568815002753 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568815002754 substrate binding pocket [chemical binding]; other site 568815002755 membrane-bound complex binding site; other site 568815002756 hinge residues; other site 568815002757 hypothetical protein; Provisional; Region: PRK06148 568815002758 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 568815002759 active site 568815002760 substrate binding site [chemical binding]; other site 568815002761 ATP binding site [chemical binding]; other site 568815002762 Peptidase family M23; Region: Peptidase_M23; pfam01551 568815002763 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 568815002764 inhibitor-cofactor binding pocket; inhibition site 568815002765 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568815002766 catalytic residue [active] 568815002767 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 568815002768 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 568815002769 AsnC family; Region: AsnC_trans_reg; pfam01037 568815002770 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568815002771 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568815002772 LysR substrate binding domain; Region: LysR_substrate; pfam03466 568815002773 dimerization interface [polypeptide binding]; other site 568815002774 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 568815002775 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 568815002776 putative ligand binding site [chemical binding]; other site 568815002777 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 568815002778 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 568815002779 Walker A/P-loop; other site 568815002780 ATP binding site [chemical binding]; other site 568815002781 Q-loop/lid; other site 568815002782 ABC transporter signature motif; other site 568815002783 Walker B; other site 568815002784 D-loop; other site 568815002785 H-loop/switch region; other site 568815002786 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 568815002787 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 568815002788 Walker A/P-loop; other site 568815002789 ATP binding site [chemical binding]; other site 568815002790 Q-loop/lid; other site 568815002791 ABC transporter signature motif; other site 568815002792 Walker B; other site 568815002793 D-loop; other site 568815002794 H-loop/switch region; other site 568815002795 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 568815002796 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568815002797 TM-ABC transporter signature motif; other site 568815002798 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 568815002799 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 568815002800 TM-ABC transporter signature motif; other site 568815002801 choline dehydrogenase; Validated; Region: PRK02106 568815002802 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 568815002803 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 568815002804 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 568815002805 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 568815002806 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 568815002807 Walker A/P-loop; other site 568815002808 ATP binding site [chemical binding]; other site 568815002809 Q-loop/lid; other site 568815002810 ABC transporter signature motif; other site 568815002811 Walker B; other site 568815002812 D-loop; other site 568815002813 H-loop/switch region; other site 568815002814 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 568815002815 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815002816 dimer interface [polypeptide binding]; other site 568815002817 conserved gate region; other site 568815002818 ABC-ATPase subunit interface; other site 568815002819 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 568815002820 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 568815002821 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 568815002822 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 568815002823 TPR motif; other site 568815002824 binding surface 568815002825 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 568815002826 binding surface 568815002827 TPR motif; other site 568815002828 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 568815002829 binding surface 568815002830 TPR motif; other site 568815002831 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 568815002832 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 568815002833 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 568815002834 putative active site [active] 568815002835 putative catalytic site [active] 568815002836 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 568815002837 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568815002838 motif II; other site 568815002839 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 568815002840 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 568815002841 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 568815002842 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 568815002843 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 568815002844 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 568815002845 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 568815002846 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 568815002847 ligand binding site [chemical binding]; other site 568815002848 homodimer interface [polypeptide binding]; other site 568815002849 NAD(P) binding site [chemical binding]; other site 568815002850 trimer interface B [polypeptide binding]; other site 568815002851 trimer interface A [polypeptide binding]; other site 568815002852 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 568815002853 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 568815002854 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 568815002855 Beta-lactamase; Region: Beta-lactamase; pfam00144 568815002856 PAS fold; Region: PAS_7; pfam12860 568815002857 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 568815002858 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 568815002859 metal binding site [ion binding]; metal-binding site 568815002860 active site 568815002861 I-site; other site 568815002862 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 568815002863 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 568815002864 classical (c) SDRs; Region: SDR_c; cd05233 568815002865 NAD(P) binding site [chemical binding]; other site 568815002866 active site 568815002867 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 568815002868 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 568815002869 catalytic triad [active] 568815002870 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 568815002871 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 568815002872 putative ligand binding site [chemical binding]; other site 568815002873 NAD binding site [chemical binding]; other site 568815002874 catalytic site [active] 568815002875 Transcriptional regulators [Transcription]; Region: PurR; COG1609 568815002876 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568815002877 DNA binding site [nucleotide binding] 568815002878 domain linker motif; other site 568815002879 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 568815002880 putative dimerization interface [polypeptide binding]; other site 568815002881 putative ligand binding site [chemical binding]; other site 568815002882 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 568815002883 MarR family; Region: MarR_2; pfam12802 568815002884 Creatinine amidohydrolase; Region: Creatininase; pfam02633 568815002885 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 568815002886 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 568815002887 P-loop, Walker A motif; other site 568815002888 Base recognition motif; other site 568815002889 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 568815002890 FOG: WD40 repeat [General function prediction only]; Region: COG2319 568815002891 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 568815002892 structural tetrad; other site 568815002893 Predicted esterase [General function prediction only]; Region: COG0400 568815002894 putative hydrolase; Provisional; Region: PRK11460 568815002895 TMAO/DMSO reductase; Reviewed; Region: PRK05363 568815002896 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 568815002897 Moco binding site; other site 568815002898 metal coordination site [ion binding]; other site 568815002899 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 568815002900 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 568815002901 homotrimer interaction site [polypeptide binding]; other site 568815002902 putative active site [active] 568815002903 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568815002904 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 568815002905 TM-ABC transporter signature motif; other site 568815002906 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 568815002907 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568815002908 TM-ABC transporter signature motif; other site 568815002909 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 568815002910 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 568815002911 Walker A/P-loop; other site 568815002912 ATP binding site [chemical binding]; other site 568815002913 Q-loop/lid; other site 568815002914 ABC transporter signature motif; other site 568815002915 Walker B; other site 568815002916 D-loop; other site 568815002917 H-loop/switch region; other site 568815002918 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 568815002919 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 568815002920 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 568815002921 putative ligand binding site [chemical binding]; other site 568815002922 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568815002923 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 568815002924 Bacterial transcriptional regulator; Region: IclR; pfam01614 568815002925 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 568815002926 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 568815002927 N-terminal plug; other site 568815002928 ligand-binding site [chemical binding]; other site 568815002929 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 568815002930 dimer interface [polypeptide binding]; other site 568815002931 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 568815002932 metal binding site [ion binding]; metal-binding site 568815002933 glutathionine S-transferase; Provisional; Region: PRK10542 568815002934 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 568815002935 C-terminal domain interface [polypeptide binding]; other site 568815002936 GSH binding site (G-site) [chemical binding]; other site 568815002937 dimer interface [polypeptide binding]; other site 568815002938 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 568815002939 dimer interface [polypeptide binding]; other site 568815002940 N-terminal domain interface [polypeptide binding]; other site 568815002941 substrate binding pocket (H-site) [chemical binding]; other site 568815002942 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 568815002943 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 568815002944 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 568815002945 metal binding site [ion binding]; metal-binding site 568815002946 active site 568815002947 I-site; other site 568815002948 Predicted dehydrogenase [General function prediction only]; Region: COG0579 568815002949 hydroxyglutarate oxidase; Provisional; Region: PRK11728 568815002950 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 568815002951 DNA polymerase III subunit epsilon; Validated; Region: PRK09182 568815002952 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 568815002953 active site 568815002954 catalytic site [active] 568815002955 substrate binding site [chemical binding]; other site 568815002956 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 568815002957 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568815002958 Walker A/P-loop; other site 568815002959 ATP binding site [chemical binding]; other site 568815002960 Q-loop/lid; other site 568815002961 ABC transporter signature motif; other site 568815002962 Walker B; other site 568815002963 D-loop; other site 568815002964 H-loop/switch region; other site 568815002965 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 568815002966 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 568815002967 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568815002968 Walker A/P-loop; other site 568815002969 ATP binding site [chemical binding]; other site 568815002970 Q-loop/lid; other site 568815002971 ABC transporter signature motif; other site 568815002972 Walker B; other site 568815002973 D-loop; other site 568815002974 H-loop/switch region; other site 568815002975 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568815002976 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 568815002977 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815002978 dimer interface [polypeptide binding]; other site 568815002979 conserved gate region; other site 568815002980 putative PBP binding loops; other site 568815002981 ABC-ATPase subunit interface; other site 568815002982 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 568815002983 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815002984 dimer interface [polypeptide binding]; other site 568815002985 conserved gate region; other site 568815002986 putative PBP binding loops; other site 568815002987 ABC-ATPase subunit interface; other site 568815002988 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 568815002989 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 568815002990 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345 568815002991 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 568815002992 putative NAD(P) binding site [chemical binding]; other site 568815002993 active site 568815002994 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 568815002995 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 568815002996 NAD(P) binding site [chemical binding]; other site 568815002997 catalytic residues [active] 568815002998 catalytic residues [active] 568815002999 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568815003000 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568815003001 DNA-binding site [nucleotide binding]; DNA binding site 568815003002 FCD domain; Region: FCD; pfam07729 568815003003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568815003004 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568815003005 putative substrate translocation pore; other site 568815003006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568815003007 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 568815003008 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 568815003009 homotrimer interaction site [polypeptide binding]; other site 568815003010 putative active site [active] 568815003011 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 568815003012 ribonuclease P; Reviewed; Region: rnpA; PRK01313 568815003013 membrane protein insertase; Provisional; Region: PRK01318 568815003014 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 568815003015 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 568815003016 G1 box; other site 568815003017 GTP/Mg2+ binding site [chemical binding]; other site 568815003018 Switch I region; other site 568815003019 G2 box; other site 568815003020 G3 box; other site 568815003021 Switch II region; other site 568815003022 G4 box; other site 568815003023 G5 box; other site 568815003024 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 568815003025 homohexameric interface [polypeptide binding]; other site 568815003026 feedback inhibition sensing region; other site 568815003027 nucleotide binding site [chemical binding]; other site 568815003028 N-acetyl-L-glutamate binding site [chemical binding]; other site 568815003029 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 568815003030 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 568815003031 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 568815003032 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 568815003033 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 568815003034 trimer interface [polypeptide binding]; other site 568815003035 active site 568815003036 substrate binding site [chemical binding]; other site 568815003037 CoA binding site [chemical binding]; other site 568815003038 Predicted transglutaminase-like cysteine proteinase [General function prediction only]; Region: COG3672 568815003039 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 568815003040 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 568815003041 metal binding site [ion binding]; metal-binding site 568815003042 dimer interface [polypeptide binding]; other site 568815003043 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 568815003044 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 568815003045 dimerization interface 3.5A [polypeptide binding]; other site 568815003046 active site 568815003047 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 568815003048 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 568815003049 putative active site [active] 568815003050 substrate binding site [chemical binding]; other site 568815003051 putative cosubstrate binding site; other site 568815003052 catalytic site [active] 568815003053 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 568815003054 substrate binding site [chemical binding]; other site 568815003055 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 568815003056 active site 568815003057 catalytic residues [active] 568815003058 metal binding site [ion binding]; metal-binding site 568815003059 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 568815003060 RmuC family; Region: RmuC; pfam02646 568815003061 Uncharacterized protein conserved in bacteria [Posttranslational modification, protein turnover, chaperones]; Region: COG3526 568815003062 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 568815003063 GIY-YIG motif/motif A; other site 568815003064 putative active site [active] 568815003065 putative metal binding site [ion binding]; other site 568815003066 GTP-binding protein LepA; Provisional; Region: PRK05433 568815003067 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 568815003068 G1 box; other site 568815003069 putative GEF interaction site [polypeptide binding]; other site 568815003070 GTP/Mg2+ binding site [chemical binding]; other site 568815003071 Switch I region; other site 568815003072 G2 box; other site 568815003073 G3 box; other site 568815003074 Switch II region; other site 568815003075 G4 box; other site 568815003076 G5 box; other site 568815003077 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 568815003078 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 568815003079 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 568815003080 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 568815003081 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 568815003082 putative NAD(P) binding site [chemical binding]; other site 568815003083 active site 568815003084 Undecaprenyl pyrophosphate phosphatase [Lipid transport and metabolism]; Region: BacA; COG1968 568815003085 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 568815003086 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 568815003087 C-terminal domain interface [polypeptide binding]; other site 568815003088 GSH binding site (G-site) [chemical binding]; other site 568815003089 dimer interface [polypeptide binding]; other site 568815003090 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 568815003091 N-terminal domain interface [polypeptide binding]; other site 568815003092 dimer interface [polypeptide binding]; other site 568815003093 substrate binding pocket (H-site) [chemical binding]; other site 568815003094 epoxyqueuosine reductase; Region: TIGR00276 568815003095 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 568815003096 HEAT repeat; Region: HEAT; pfam02985 568815003097 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 568815003098 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 568815003099 putative NAD(P) binding site [chemical binding]; other site 568815003100 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 568815003101 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 568815003102 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 568815003103 active site 568815003104 dimer interfaces [polypeptide binding]; other site 568815003105 catalytic residues [active] 568815003106 Glucokinase [Carbohydrate transport and metabolism]; Region: Glk; COG0837 568815003107 glucokinase, proteobacterial type; Region: glk; TIGR00749 568815003108 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568815003109 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568815003110 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 568815003111 Walker A/P-loop; other site 568815003112 ATP binding site [chemical binding]; other site 568815003113 Q-loop/lid; other site 568815003114 ABC transporter signature motif; other site 568815003115 Walker B; other site 568815003116 D-loop; other site 568815003117 H-loop/switch region; other site 568815003118 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 568815003119 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 568815003120 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 568815003121 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568815003122 catalytic core [active] 568815003123 Helix-turn-helix domain; Region: HTH_17; pfam12728 568815003124 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 568815003125 non-specific DNA binding site [nucleotide binding]; other site 568815003126 salt bridge; other site 568815003127 sequence-specific DNA binding site [nucleotide binding]; other site 568815003128 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 568815003129 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 568815003130 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 568815003131 active site 568815003132 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 568815003133 putative FMN binding site [chemical binding]; other site 568815003134 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 568815003135 Ligand Binding Site [chemical binding]; other site 568815003136 Predicted membrane protein [Function unknown]; Region: COG3714 568815003137 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 568815003138 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 568815003139 NAD(P) binding site [chemical binding]; other site 568815003140 catalytic residues [active] 568815003141 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 568815003142 putative catalytic site [active] 568815003143 putative metal binding site [ion binding]; other site 568815003144 putative phosphate binding site [ion binding]; other site 568815003145 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 568815003146 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 568815003147 putative active site [active] 568815003148 catalytic site [active] 568815003149 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 568815003150 putative active site [active] 568815003151 catalytic site [active] 568815003152 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 568815003153 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 568815003154 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 568815003155 G1 box; other site 568815003156 putative GEF interaction site [polypeptide binding]; other site 568815003157 GTP/Mg2+ binding site [chemical binding]; other site 568815003158 Switch I region; other site 568815003159 G2 box; other site 568815003160 G3 box; other site 568815003161 Switch II region; other site 568815003162 G4 box; other site 568815003163 G5 box; other site 568815003164 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 568815003165 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 568815003166 Flavoprotein; Region: Flavoprotein; pfam02441 568815003167 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 568815003168 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 568815003169 ABC1 family; Region: ABC1; pfam03109 568815003170 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 568815003171 active site 568815003172 ATP binding site [chemical binding]; other site 568815003173 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 568815003174 substrate binding site [chemical binding]; other site 568815003175 activation loop (A-loop); other site 568815003176 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 568815003177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568815003178 S-adenosylmethionine binding site [chemical binding]; other site 568815003179 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568815003180 active site 568815003181 hypothetical protein; Provisional; Region: PRK00736 568815003182 methionine sulfoxide reductase A; Provisional; Region: PRK00058 568815003183 putative transposase OrfB; Reviewed; Region: PHA02517 568815003184 HTH-like domain; Region: HTH_21; pfam13276 568815003185 Integrase core domain; Region: rve; pfam00665 568815003186 Integrase core domain; Region: rve_3; pfam13683 568815003187 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 568815003188 Transposase; Region: HTH_Tnp_1; pfam01527 568815003189 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568815003190 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568815003191 DNA-binding site [nucleotide binding]; DNA binding site 568815003192 FCD domain; Region: FCD; pfam07729 568815003193 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 568815003194 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 568815003195 tetramerization interface [polypeptide binding]; other site 568815003196 NAD(P) binding site [chemical binding]; other site 568815003197 catalytic residues [active] 568815003198 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568815003199 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568815003200 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 568815003201 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568815003202 Walker A/P-loop; other site 568815003203 ATP binding site [chemical binding]; other site 568815003204 Q-loop/lid; other site 568815003205 ABC transporter signature motif; other site 568815003206 Walker B; other site 568815003207 D-loop; other site 568815003208 H-loop/switch region; other site 568815003209 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 568815003210 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 568815003211 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568815003212 Walker A/P-loop; other site 568815003213 ATP binding site [chemical binding]; other site 568815003214 Q-loop/lid; other site 568815003215 ABC transporter signature motif; other site 568815003216 Walker B; other site 568815003217 D-loop; other site 568815003218 H-loop/switch region; other site 568815003219 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 568815003220 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 568815003221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815003222 dimer interface [polypeptide binding]; other site 568815003223 conserved gate region; other site 568815003224 putative PBP binding loops; other site 568815003225 ABC-ATPase subunit interface; other site 568815003226 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 568815003227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815003228 dimer interface [polypeptide binding]; other site 568815003229 conserved gate region; other site 568815003230 putative PBP binding loops; other site 568815003231 ABC-ATPase subunit interface; other site 568815003232 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568815003233 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 568815003234 Bacterial transcriptional regulator; Region: IclR; pfam01614 568815003235 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 568815003236 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 568815003237 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 568815003238 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 568815003239 tetramer interface [polypeptide binding]; other site 568815003240 TPP-binding site [chemical binding]; other site 568815003241 heterodimer interface [polypeptide binding]; other site 568815003242 phosphorylation loop region [posttranslational modification] 568815003243 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 568815003244 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 568815003245 alpha subunit interface [polypeptide binding]; other site 568815003246 TPP binding site [chemical binding]; other site 568815003247 heterodimer interface [polypeptide binding]; other site 568815003248 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 568815003249 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 568815003250 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 568815003251 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 568815003252 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 568815003253 enoyl-CoA hydratase; Provisional; Region: PRK08138 568815003254 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568815003255 substrate binding site [chemical binding]; other site 568815003256 oxyanion hole (OAH) forming residues; other site 568815003257 trimer interface [polypeptide binding]; other site 568815003258 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 568815003259 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 568815003260 active site 568815003261 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 568815003262 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 568815003263 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 568815003264 active site 568815003265 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 568815003266 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 568815003267 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 568815003268 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 568815003269 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815003270 dimer interface [polypeptide binding]; other site 568815003271 conserved gate region; other site 568815003272 putative PBP binding loops; other site 568815003273 ABC-ATPase subunit interface; other site 568815003274 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 568815003275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815003276 dimer interface [polypeptide binding]; other site 568815003277 conserved gate region; other site 568815003278 putative PBP binding loops; other site 568815003279 ABC-ATPase subunit interface; other site 568815003280 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 568815003281 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568815003282 Walker A/P-loop; other site 568815003283 ATP binding site [chemical binding]; other site 568815003284 Q-loop/lid; other site 568815003285 ABC transporter signature motif; other site 568815003286 Walker B; other site 568815003287 D-loop; other site 568815003288 H-loop/switch region; other site 568815003289 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568815003290 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 568815003291 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568815003292 Walker A/P-loop; other site 568815003293 ATP binding site [chemical binding]; other site 568815003294 Q-loop/lid; other site 568815003295 ABC transporter signature motif; other site 568815003296 Walker B; other site 568815003297 D-loop; other site 568815003298 H-loop/switch region; other site 568815003299 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 568815003300 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568815003301 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568815003302 DNA-binding site [nucleotide binding]; DNA binding site 568815003303 FCD domain; Region: FCD; pfam07729 568815003304 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 568815003305 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 568815003306 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 568815003307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815003308 dimer interface [polypeptide binding]; other site 568815003309 conserved gate region; other site 568815003310 putative PBP binding loops; other site 568815003311 ABC-ATPase subunit interface; other site 568815003312 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 568815003313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815003314 dimer interface [polypeptide binding]; other site 568815003315 conserved gate region; other site 568815003316 putative PBP binding loops; other site 568815003317 ABC-ATPase subunit interface; other site 568815003318 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 568815003319 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568815003320 Walker A/P-loop; other site 568815003321 ATP binding site [chemical binding]; other site 568815003322 Q-loop/lid; other site 568815003323 ABC transporter signature motif; other site 568815003324 Walker B; other site 568815003325 D-loop; other site 568815003326 H-loop/switch region; other site 568815003327 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568815003328 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 568815003329 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568815003330 Walker A/P-loop; other site 568815003331 ATP binding site [chemical binding]; other site 568815003332 Q-loop/lid; other site 568815003333 ABC transporter signature motif; other site 568815003334 Walker B; other site 568815003335 D-loop; other site 568815003336 H-loop/switch region; other site 568815003337 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 568815003338 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 568815003339 amidase; Provisional; Region: PRK07486 568815003340 Amidase; Region: Amidase; cl11426 568815003341 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 568815003342 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 568815003343 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 568815003344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815003345 dimer interface [polypeptide binding]; other site 568815003346 conserved gate region; other site 568815003347 putative PBP binding loops; other site 568815003348 ABC-ATPase subunit interface; other site 568815003349 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815003350 dimer interface [polypeptide binding]; other site 568815003351 conserved gate region; other site 568815003352 putative PBP binding loops; other site 568815003353 ABC-ATPase subunit interface; other site 568815003354 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 568815003355 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568815003356 Walker A/P-loop; other site 568815003357 ATP binding site [chemical binding]; other site 568815003358 Q-loop/lid; other site 568815003359 ABC transporter signature motif; other site 568815003360 Walker B; other site 568815003361 D-loop; other site 568815003362 H-loop/switch region; other site 568815003363 TOBE domain; Region: TOBE_2; pfam08402 568815003364 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 568815003365 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 568815003366 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568815003367 catalytic residue [active] 568815003368 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235 568815003369 intersubunit interface [polypeptide binding]; other site 568815003370 active site 568815003371 Zn2+ binding site [ion binding]; other site 568815003372 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 568815003373 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 568815003374 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 568815003375 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 568815003376 Transposase; Region: HTH_Tnp_1; pfam01527 568815003377 putative transposase OrfB; Reviewed; Region: PHA02517 568815003378 HTH-like domain; Region: HTH_21; pfam13276 568815003379 Integrase core domain; Region: rve; pfam00665 568815003380 Integrase core domain; Region: rve_3; pfam13683 568815003381 Predicted transcriptional regulator [Transcription]; Region: COG1959 568815003382 Transcriptional regulator; Region: Rrf2; pfam02082 568815003383 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 568815003384 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 568815003385 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 568815003386 ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531 568815003387 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 568815003388 metal binding site [ion binding]; metal-binding site 568815003389 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 568815003390 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 568815003391 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 568815003392 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 568815003393 ABC-ATPase subunit interface; other site 568815003394 dimer interface [polypeptide binding]; other site 568815003395 putative PBP binding regions; other site 568815003396 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 568815003397 metal binding site 2 [ion binding]; metal-binding site 568815003398 putative DNA binding helix; other site 568815003399 metal binding site 1 [ion binding]; metal-binding site 568815003400 dimer interface [polypeptide binding]; other site 568815003401 structural Zn2+ binding site [ion binding]; other site 568815003402 Rod binding protein; Region: Rod-binding; pfam10135 568815003403 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 568815003404 flagellar biosynthesis protein FlhA; Reviewed; Region: flhA; PRK12792 568815003405 FHIPEP family; Region: FHIPEP; pfam00771 568815003406 flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010 568815003407 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009 568815003408 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 568815003409 Flagellar biosynthesis regulator FlbT [Cell motility and secretion]; Region: FlbT; COG5443 568815003410 Flagellar biosynthesis regulator FlaF [Cell motility and secretion]; Region: FlaF; COG5442 568815003411 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793 568815003412 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 568815003413 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 568815003414 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 568815003415 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 568815003416 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 568815003417 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 568815003418 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 568815003419 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 568815003420 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 568815003421 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568815003422 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568815003423 DNA binding site [nucleotide binding] 568815003424 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 568815003425 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 568815003426 N-acetyl-D-glucosamine binding site [chemical binding]; other site 568815003427 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 568815003428 chemotaxis protein; Reviewed; Region: PRK12798 568815003429 flagellar motor protein MotB; Validated; Region: motB; PRK05996 568815003430 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 568815003431 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 568815003432 ligand binding site [chemical binding]; other site 568815003433 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 568815003434 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 568815003435 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 568815003436 flagellin; Reviewed; Region: PRK12687 568815003437 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 568815003438 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568815003439 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568815003440 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568815003441 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 568815003442 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568815003443 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568815003444 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568815003445 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568815003446 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 568815003447 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 568815003448 Autotransporter beta-domain; Region: Autotransporter; pfam03797 568815003449 Uncharacterized conserved protein [Function unknown]; Region: COG3268 568815003450 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 568815003451 D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634 568815003452 putative ligand binding site [chemical binding]; other site 568815003453 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 568815003454 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 568815003455 Walker A/P-loop; other site 568815003456 ATP binding site [chemical binding]; other site 568815003457 Q-loop/lid; other site 568815003458 ABC transporter signature motif; other site 568815003459 Walker B; other site 568815003460 D-loop; other site 568815003461 H-loop/switch region; other site 568815003462 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 568815003463 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568815003464 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 568815003465 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 568815003466 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568815003467 TM-ABC transporter signature motif; other site 568815003468 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 568815003469 HTH domain; Region: HTH_11; cl17392 568815003470 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568815003471 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 568815003472 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 568815003473 NAD(P) binding site [chemical binding]; other site 568815003474 catalytic residues [active] 568815003475 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Region: HpaI; TIGR02311 568815003476 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 568815003477 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 568815003478 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 568815003479 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 568815003480 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 568815003481 tetramer interface [polypeptide binding]; other site 568815003482 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 568815003483 tetramer interface [polypeptide binding]; other site 568815003484 active site 568815003485 metal binding site [ion binding]; metal-binding site 568815003486 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 568815003487 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 568815003488 NAD binding site [chemical binding]; other site 568815003489 catalytic residues [active] 568815003490 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 568815003491 putative substrate binding pocket [chemical binding]; other site 568815003492 trimer interface [polypeptide binding]; other site 568815003493 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 568815003494 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 568815003495 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 568815003496 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 568815003497 active site 568815003498 ATP binding site [chemical binding]; other site 568815003499 substrate binding site [chemical binding]; other site 568815003500 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 568815003501 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 568815003502 inhibitor-cofactor binding pocket; inhibition site 568815003503 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568815003504 catalytic residue [active] 568815003505 hypothetical protein; Provisional; Region: PRK07481 568815003506 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 568815003507 inhibitor-cofactor binding pocket; inhibition site 568815003508 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568815003509 catalytic residue [active] 568815003510 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 568815003511 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568815003512 motif II; other site 568815003513 Uncharacterized conserved protein [Function unknown]; Region: COG5441; cl02262 568815003514 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 568815003515 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 568815003516 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568815003517 Bacterial transcriptional regulator; Region: IclR; pfam01614 568815003518 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 568815003519 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 568815003520 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 568815003521 NAD(P) binding site [chemical binding]; other site 568815003522 catalytic residues [active] 568815003523 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 568815003524 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 568815003525 active site 568815003526 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 568815003527 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 568815003528 putative ligand binding site [chemical binding]; other site 568815003529 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 568815003530 TM-ABC transporter signature motif; other site 568815003531 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 568815003532 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 568815003533 TM-ABC transporter signature motif; other site 568815003534 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 568815003535 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 568815003536 Walker A/P-loop; other site 568815003537 ATP binding site [chemical binding]; other site 568815003538 Q-loop/lid; other site 568815003539 ABC transporter signature motif; other site 568815003540 Walker B; other site 568815003541 D-loop; other site 568815003542 H-loop/switch region; other site 568815003543 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 568815003544 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 568815003545 Walker A/P-loop; other site 568815003546 ATP binding site [chemical binding]; other site 568815003547 Q-loop/lid; other site 568815003548 ABC transporter signature motif; other site 568815003549 Walker B; other site 568815003550 D-loop; other site 568815003551 H-loop/switch region; other site 568815003552 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 568815003553 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 568815003554 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568815003555 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568815003556 DNA-binding site [nucleotide binding]; DNA binding site 568815003557 UTRA domain; Region: UTRA; pfam07702 568815003558 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 568815003559 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 568815003560 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 568815003561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815003562 dimer interface [polypeptide binding]; other site 568815003563 conserved gate region; other site 568815003564 putative PBP binding loops; other site 568815003565 ABC-ATPase subunit interface; other site 568815003566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815003567 dimer interface [polypeptide binding]; other site 568815003568 conserved gate region; other site 568815003569 putative PBP binding loops; other site 568815003570 ABC-ATPase subunit interface; other site 568815003571 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 568815003572 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568815003573 Walker A/P-loop; other site 568815003574 ATP binding site [chemical binding]; other site 568815003575 Q-loop/lid; other site 568815003576 ABC transporter signature motif; other site 568815003577 Walker B; other site 568815003578 D-loop; other site 568815003579 H-loop/switch region; other site 568815003580 TOBE domain; Region: TOBE_2; pfam08402 568815003581 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 568815003582 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 568815003583 active site 568815003584 metal binding site [ion binding]; metal-binding site 568815003585 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 568815003586 Sulfatase; Region: Sulfatase; pfam00884 568815003587 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 568815003588 NMT1-like family; Region: NMT1_2; pfam13379 568815003589 substrate binding pocket [chemical binding]; other site 568815003590 membrane-bound complex binding site; other site 568815003591 hinge residues; other site 568815003592 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 568815003593 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 568815003594 Walker A/P-loop; other site 568815003595 ATP binding site [chemical binding]; other site 568815003596 Q-loop/lid; other site 568815003597 ABC transporter signature motif; other site 568815003598 Walker B; other site 568815003599 D-loop; other site 568815003600 H-loop/switch region; other site 568815003601 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 568815003602 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815003603 dimer interface [polypeptide binding]; other site 568815003604 conserved gate region; other site 568815003605 putative PBP binding loops; other site 568815003606 ABC-ATPase subunit interface; other site 568815003607 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 568815003608 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 568815003609 nucleotide binding site [chemical binding]; other site 568815003610 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 568815003611 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 568815003612 N-terminal plug; other site 568815003613 ligand-binding site [chemical binding]; other site 568815003614 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 568815003615 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568815003616 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 568815003617 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338 568815003618 putative ligand binding site [chemical binding]; other site 568815003619 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568815003620 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 568815003621 TM-ABC transporter signature motif; other site 568815003622 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 568815003623 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 568815003624 TM-ABC transporter signature motif; other site 568815003625 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 568815003626 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 568815003627 Walker A/P-loop; other site 568815003628 ATP binding site [chemical binding]; other site 568815003629 Q-loop/lid; other site 568815003630 ABC transporter signature motif; other site 568815003631 Walker B; other site 568815003632 D-loop; other site 568815003633 H-loop/switch region; other site 568815003634 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 568815003635 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 568815003636 Walker A/P-loop; other site 568815003637 ATP binding site [chemical binding]; other site 568815003638 Q-loop/lid; other site 568815003639 ABC transporter signature motif; other site 568815003640 Walker B; other site 568815003641 D-loop; other site 568815003642 H-loop/switch region; other site 568815003643 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 568815003644 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568815003645 Soluble P-type ATPase [General function prediction only]; Region: COG4087 568815003646 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 568815003647 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568815003648 FeS/SAM binding site; other site 568815003649 HemN C-terminal domain; Region: HemN_C; pfam06969 568815003650 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 568815003651 MerR family regulatory protein; Region: MerR; pfam00376 568815003652 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 568815003653 P-loop; other site 568815003654 Magnesium ion binding site [ion binding]; other site 568815003655 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 568815003656 P-loop; other site 568815003657 Magnesium ion binding site [ion binding]; other site 568815003658 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 568815003659 ParB-like nuclease domain; Region: ParB; smart00470 568815003660 DnaA N-terminal domain; Region: DnaA_N; pfam11638 568815003661 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 568815003662 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 568815003663 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 568815003664 DnaA box-binding interface [nucleotide binding]; other site 568815003665 DNA polymerase III subunit beta; Validated; Region: PRK05643 568815003666 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 568815003667 putative DNA binding surface [nucleotide binding]; other site 568815003668 dimer interface [polypeptide binding]; other site 568815003669 beta-clamp/clamp loader binding surface; other site 568815003670 beta-clamp/translesion DNA polymerase binding surface; other site 568815003671 recombination protein F; Reviewed; Region: recF; PRK00064 568815003672 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 568815003673 Walker A/P-loop; other site 568815003674 ATP binding site [chemical binding]; other site 568815003675 Q-loop/lid; other site 568815003676 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568815003677 ABC transporter signature motif; other site 568815003678 Walker B; other site 568815003679 D-loop; other site 568815003680 H-loop/switch region; other site 568815003681 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 568815003682 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 568815003683 ATP binding site [chemical binding]; other site 568815003684 substrate interface [chemical binding]; other site 568815003685 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 568815003686 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 568815003687 putative ligand binding site [chemical binding]; other site 568815003688 NAD binding site [chemical binding]; other site 568815003689 dimerization interface [polypeptide binding]; other site 568815003690 catalytic site [active] 568815003691 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 568815003692 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568815003693 Walker A/P-loop; other site 568815003694 ATP binding site [chemical binding]; other site 568815003695 Q-loop/lid; other site 568815003696 ABC transporter signature motif; other site 568815003697 Walker B; other site 568815003698 D-loop; other site 568815003699 H-loop/switch region; other site 568815003700 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 568815003701 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568815003702 Walker A/P-loop; other site 568815003703 ATP binding site [chemical binding]; other site 568815003704 Q-loop/lid; other site 568815003705 ABC transporter signature motif; other site 568815003706 Walker B; other site 568815003707 D-loop; other site 568815003708 H-loop/switch region; other site 568815003709 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568815003710 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 568815003711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815003712 dimer interface [polypeptide binding]; other site 568815003713 conserved gate region; other site 568815003714 putative PBP binding loops; other site 568815003715 ABC-ATPase subunit interface; other site 568815003716 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 568815003717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815003718 dimer interface [polypeptide binding]; other site 568815003719 conserved gate region; other site 568815003720 putative PBP binding loops; other site 568815003721 ABC-ATPase subunit interface; other site 568815003722 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 568815003723 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 568815003724 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 568815003725 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 568815003726 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 568815003727 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 568815003728 dimerization interface [polypeptide binding]; other site 568815003729 ligand binding site [chemical binding]; other site 568815003730 enoyl-CoA hydratase; Provisional; Region: PRK07468 568815003731 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568815003732 substrate binding site [chemical binding]; other site 568815003733 oxyanion hole (OAH) forming residues; other site 568815003734 trimer interface [polypeptide binding]; other site 568815003735 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 568815003736 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 568815003737 active site 568815003738 catalytic residues [active] 568815003739 metal binding site [ion binding]; metal-binding site 568815003740 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 568815003741 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 568815003742 ATP-grasp domain; Region: ATP-grasp_4; cl17255 568815003743 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 568815003744 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 568815003745 carboxyltransferase (CT) interaction site; other site 568815003746 biotinylation site [posttranslational modification]; other site 568815003747 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 568815003748 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 568815003749 isovaleryl-CoA dehydrogenase; Region: PLN02519 568815003750 substrate binding site [chemical binding]; other site 568815003751 FAD binding site [chemical binding]; other site 568815003752 catalytic base [active] 568815003753 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 568815003754 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 568815003755 acyl-activating enzyme (AAE) consensus motif; other site 568815003756 putative AMP binding site [chemical binding]; other site 568815003757 putative active site [active] 568815003758 putative CoA binding site [chemical binding]; other site 568815003759 CHRD domain; Region: CHRD; pfam07452 568815003760 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 568815003761 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530 568815003762 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 568815003763 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 568815003764 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 568815003765 hinge; other site 568815003766 active site 568815003767 cytidylate kinase; Provisional; Region: cmk; PRK00023 568815003768 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 568815003769 CMP-binding site; other site 568815003770 The sites determining sugar specificity; other site 568815003771 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 568815003772 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 568815003773 RNA binding site [nucleotide binding]; other site 568815003774 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 568815003775 RNA binding site [nucleotide binding]; other site 568815003776 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 568815003777 RNA binding site [nucleotide binding]; other site 568815003778 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 568815003779 RNA binding site [nucleotide binding]; other site 568815003780 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 568815003781 RNA binding site [nucleotide binding]; other site 568815003782 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 568815003783 RNA binding site [nucleotide binding]; other site 568815003784 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 568815003785 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568815003786 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 568815003787 Predicted membrane protein [Function unknown]; Region: COG2855 568815003788 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 568815003789 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568815003790 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 568815003791 putative dimerization interface [polypeptide binding]; other site 568815003792 lytic murein transglycosylase; Region: MltB_2; TIGR02283 568815003793 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 568815003794 N-acetyl-D-glucosamine binding site [chemical binding]; other site 568815003795 recombination protein RecR; Reviewed; Region: recR; PRK00076 568815003796 RecR protein; Region: RecR; pfam02132 568815003797 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 568815003798 putative active site [active] 568815003799 putative metal-binding site [ion binding]; other site 568815003800 tetramer interface [polypeptide binding]; other site 568815003801 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 568815003802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568815003803 Walker A motif; other site 568815003804 ATP binding site [chemical binding]; other site 568815003805 Walker B motif; other site 568815003806 arginine finger; other site 568815003807 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 568815003808 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 568815003809 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 568815003810 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 568815003811 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 568815003812 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 568815003813 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 568815003814 putative NADH binding site [chemical binding]; other site 568815003815 putative active site [active] 568815003816 nudix motif; other site 568815003817 putative metal binding site [ion binding]; other site 568815003818 prephenate dehydratase; Provisional; Region: PRK11899 568815003819 Prephenate dehydratase; Region: PDT; pfam00800 568815003820 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 568815003821 putative L-Phe binding site [chemical binding]; other site 568815003822 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 568815003823 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 568815003824 Ligand binding site; other site 568815003825 oligomer interface; other site 568815003826 Cytochrome c2 [Energy production and conversion]; Region: COG3474 568815003827 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 568815003828 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 568815003829 putative MPT binding site; other site 568815003830 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 568815003831 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 568815003832 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 568815003833 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 568815003834 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 568815003835 D-pathway; other site 568815003836 Putative ubiquinol binding site [chemical binding]; other site 568815003837 Low-spin heme (heme b) binding site [chemical binding]; other site 568815003838 Putative water exit pathway; other site 568815003839 Binuclear center (heme o3/CuB) [ion binding]; other site 568815003840 K-pathway; other site 568815003841 Putative proton exit pathway; other site 568815003842 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 568815003843 Subunit I/III interface [polypeptide binding]; other site 568815003844 Subunit III/IV interface [polypeptide binding]; other site 568815003845 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 568815003846 Bacterial SH3 domain; Region: SH3_3; pfam08239 568815003847 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 568815003848 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 568815003849 Surface antigen; Region: Bac_surface_Ag; pfam01103 568815003850 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 568815003851 Family of unknown function (DUF490); Region: DUF490; pfam04357 568815003852 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 568815003853 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 568815003854 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 568815003855 Copper(I)-binding protein [Inorganic ion transport and metabolism]; Region: COG2847 568815003856 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 568815003857 dimer interface [polypeptide binding]; other site 568815003858 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 568815003859 active site 568815003860 metal binding site [ion binding]; metal-binding site 568815003861 glutathione binding site [chemical binding]; other site 568815003862 Domain of unknown function DUF59; Region: DUF59; pfam01883 568815003863 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 568815003864 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 568815003865 Walker A motif; other site 568815003866 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 568815003867 phosphoglucomutase; Region: PLN02307 568815003868 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 568815003869 substrate binding site [chemical binding]; other site 568815003870 dimer interface [polypeptide binding]; other site 568815003871 active site 568815003872 metal binding site [ion binding]; metal-binding site 568815003873 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568815003874 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568815003875 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 568815003876 putative effector binding pocket; other site 568815003877 putative dimerization interface [polypeptide binding]; other site 568815003878 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 568815003879 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 568815003880 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 568815003881 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 568815003882 active site 568815003883 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 568815003884 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 568815003885 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 568815003886 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 568815003887 N-acetyl-D-glucosamine binding site [chemical binding]; other site 568815003888 catalytic residue [active] 568815003889 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 568815003890 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 568815003891 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 568815003892 putative active site [active] 568815003893 putative PHP Thumb interface [polypeptide binding]; other site 568815003894 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 568815003895 generic binding surface II; other site 568815003896 generic binding surface I; other site 568815003897 DNA Polymerase Y-family; Region: PolY_like; cd03468 568815003898 active site 568815003899 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 568815003900 DNA binding site [nucleotide binding] 568815003901 Uncharacterized conserved protein [Function unknown]; Region: COG4544 568815003902 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 568815003903 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 568815003904 trimer interface [polypeptide binding]; other site 568815003905 Haemagglutinin; Region: HIM; pfam05662 568815003906 YadA-like C-terminal region; Region: YadA; pfam03895 568815003907 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 568815003908 argininosuccinate synthase; Provisional; Region: PRK13820 568815003909 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 568815003910 ANP binding site [chemical binding]; other site 568815003911 Substrate Binding Site II [chemical binding]; other site 568815003912 Substrate Binding Site I [chemical binding]; other site 568815003913 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 568815003914 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 568815003915 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568815003916 FeS/SAM binding site; other site 568815003917 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 568815003918 Uncharacterized conserved protein [Function unknown]; Region: COG3339 568815003919 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 568815003920 aromatic arch; other site 568815003921 DCoH dimer interaction site [polypeptide binding]; other site 568815003922 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 568815003923 DCoH tetramer interaction site [polypeptide binding]; other site 568815003924 substrate binding site [chemical binding]; other site 568815003925 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 568815003926 Low molecular weight phosphatase family; Region: LMWPc; cd00115 568815003927 active site 568815003928 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 568815003929 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 568815003930 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 568815003931 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 568815003932 active site 568815003933 catalytic triad [active] 568815003934 oxyanion hole [active] 568815003935 switch loop; other site 568815003936 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 568815003937 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 568815003938 Walker A/P-loop; other site 568815003939 ATP binding site [chemical binding]; other site 568815003940 Q-loop/lid; other site 568815003941 ABC transporter signature motif; other site 568815003942 Walker B; other site 568815003943 D-loop; other site 568815003944 H-loop/switch region; other site 568815003945 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 568815003946 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 568815003947 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 568815003948 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 568815003949 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568815003950 Coenzyme A binding pocket [chemical binding]; other site 568815003951 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 568815003952 Uncharacterized secreted protein [Function unknown]; Region: COG5429 568815003953 aconitate hydratase; Validated; Region: PRK09277 568815003954 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 568815003955 substrate binding site [chemical binding]; other site 568815003956 ligand binding site [chemical binding]; other site 568815003957 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 568815003958 substrate binding site [chemical binding]; other site 568815003959 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 568815003960 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 568815003961 Walker A/P-loop; other site 568815003962 ATP binding site [chemical binding]; other site 568815003963 Q-loop/lid; other site 568815003964 ABC transporter signature motif; other site 568815003965 Walker B; other site 568815003966 D-loop; other site 568815003967 H-loop/switch region; other site 568815003968 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386 568815003969 heme exporter protein CcmC; Region: ccmC; TIGR01191 568815003970 heme exporter protein CcmD; Region: cytochro_ccmD; TIGR03141 568815003971 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 568815003972 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 568815003973 catalytic residues [active] 568815003974 central insert; other site 568815003975 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 568815003976 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 568815003977 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568815003978 active site 568815003979 phosphorylation site [posttranslational modification] 568815003980 intermolecular recognition site; other site 568815003981 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 568815003982 AsnC family; Region: AsnC_trans_reg; pfam01037 568815003983 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 568815003984 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604 568815003985 Uncharacterized conserved protein [Function unknown]; Region: COG1434 568815003986 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 568815003987 putative active site [active] 568815003988 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 568815003989 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 568815003990 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 568815003991 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815003992 dimer interface [polypeptide binding]; other site 568815003993 conserved gate region; other site 568815003994 putative PBP binding loops; other site 568815003995 ABC-ATPase subunit interface; other site 568815003996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815003997 dimer interface [polypeptide binding]; other site 568815003998 conserved gate region; other site 568815003999 putative PBP binding loops; other site 568815004000 ABC-ATPase subunit interface; other site 568815004001 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 568815004002 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 568815004003 Walker A/P-loop; other site 568815004004 ATP binding site [chemical binding]; other site 568815004005 Q-loop/lid; other site 568815004006 ABC transporter signature motif; other site 568815004007 Walker B; other site 568815004008 D-loop; other site 568815004009 H-loop/switch region; other site 568815004010 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 568815004011 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 568815004012 Putative glucoamylase; Region: Glycoamylase; pfam10091 568815004013 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 568815004014 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 568815004015 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 568815004016 Protein of unknown function, DUF608; Region: DUF608; pfam04685 568815004017 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 568815004018 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 568815004019 active site 568815004020 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568815004021 S-adenosylmethionine binding site [chemical binding]; other site 568815004022 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 568815004023 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 568815004024 putative substrate binding site [chemical binding]; other site 568815004025 putative ATP binding site [chemical binding]; other site 568815004026 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 568815004027 classical (c) SDRs; Region: SDR_c; cd05233 568815004028 NAD(P) binding site [chemical binding]; other site 568815004029 active site 568815004030 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 568815004031 Transglycosylase; Region: Transgly; pfam00912 568815004032 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 568815004033 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 568815004034 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 568815004035 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 568815004036 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 568815004037 catalytic site [active] 568815004038 putative active site [active] 568815004039 putative substrate binding site [chemical binding]; other site 568815004040 hypothetical protein; Validated; Region: PRK09104 568815004041 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 568815004042 metal binding site [ion binding]; metal-binding site 568815004043 putative dimer interface [polypeptide binding]; other site 568815004044 DNA polymerase I; Region: pola; TIGR00593 568815004045 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 568815004046 active site 568815004047 metal binding site 1 [ion binding]; metal-binding site 568815004048 putative 5' ssDNA interaction site; other site 568815004049 metal binding site 3; metal-binding site 568815004050 metal binding site 2 [ion binding]; metal-binding site 568815004051 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 568815004052 putative DNA binding site [nucleotide binding]; other site 568815004053 putative metal binding site [ion binding]; other site 568815004054 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 568815004055 active site 568815004056 catalytic site [active] 568815004057 substrate binding site [chemical binding]; other site 568815004058 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 568815004059 active site 568815004060 DNA binding site [nucleotide binding] 568815004061 catalytic site [active] 568815004062 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 568815004063 DEAD-like helicases superfamily; Region: DEXDc; smart00487 568815004064 ATP binding site [chemical binding]; other site 568815004065 Mg++ binding site [ion binding]; other site 568815004066 motif III; other site 568815004067 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568815004068 nucleotide binding region [chemical binding]; other site 568815004069 ATP-binding site [chemical binding]; other site 568815004070 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 568815004071 RNA binding site [nucleotide binding]; other site 568815004072 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 568815004073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568815004074 Mg2+ binding site [ion binding]; other site 568815004075 G-X-G motif; other site 568815004076 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 568815004077 anchoring element; other site 568815004078 dimer interface [polypeptide binding]; other site 568815004079 ATP binding site [chemical binding]; other site 568815004080 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 568815004081 active site 568815004082 putative metal-binding site [ion binding]; other site 568815004083 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 568815004084 S-formylglutathione hydrolase; Region: PLN02442 568815004085 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 568815004086 Predicted membrane protein [Function unknown]; Region: COG4291 568815004087 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 568815004088 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568815004089 Coenzyme A binding pocket [chemical binding]; other site 568815004090 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 568815004091 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 568815004092 substrate binding site [chemical binding]; other site 568815004093 catalytic Zn binding site [ion binding]; other site 568815004094 NAD binding site [chemical binding]; other site 568815004095 structural Zn binding site [ion binding]; other site 568815004096 dimer interface [polypeptide binding]; other site 568815004097 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 568815004098 putative metal binding site [ion binding]; other site 568815004099 putative homodimer interface [polypeptide binding]; other site 568815004100 putative homotetramer interface [polypeptide binding]; other site 568815004101 putative homodimer-homodimer interface [polypeptide binding]; other site 568815004102 putative allosteric switch controlling residues; other site 568815004103 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 568815004104 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568815004105 ATP binding site [chemical binding]; other site 568815004106 putative Mg++ binding site [ion binding]; other site 568815004107 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568815004108 nucleotide binding region [chemical binding]; other site 568815004109 ATP-binding site [chemical binding]; other site 568815004110 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 568815004111 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 568815004112 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568815004113 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568815004114 ATP binding site [chemical binding]; other site 568815004115 Mg2+ binding site [ion binding]; other site 568815004116 G-X-G motif; other site 568815004117 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 568815004118 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 568815004119 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568815004120 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 568815004121 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 568815004122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568815004123 active site 568815004124 phosphorylation site [posttranslational modification] 568815004125 intermolecular recognition site; other site 568815004126 dimerization interface [polypeptide binding]; other site 568815004127 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 568815004128 Protein of unknown function (DUF1052); Region: DUF1052; pfam06319 568815004129 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 568815004130 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 568815004131 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 568815004132 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 568815004133 Universal stress protein family; Region: Usp; pfam00582 568815004134 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 568815004135 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 568815004136 active site 568815004137 HIGH motif; other site 568815004138 dimer interface [polypeptide binding]; other site 568815004139 KMSKS motif; other site 568815004140 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 568815004141 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 568815004142 PII uridylyl-transferase; Provisional; Region: PRK05092 568815004143 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 568815004144 metal binding triad; other site 568815004145 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 568815004146 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 568815004147 Zn2+ binding site [ion binding]; other site 568815004148 Mg2+ binding site [ion binding]; other site 568815004149 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 568815004150 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 568815004151 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 568815004152 Malic enzyme, N-terminal domain; Region: malic; pfam00390 568815004153 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 568815004154 putative NAD(P) binding site [chemical binding]; other site 568815004155 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 568815004156 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 568815004157 MutS domain I; Region: MutS_I; pfam01624 568815004158 MutS domain II; Region: MutS_II; pfam05188 568815004159 MutS domain III; Region: MutS_III; pfam05192 568815004160 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 568815004161 Walker A/P-loop; other site 568815004162 ATP binding site [chemical binding]; other site 568815004163 Q-loop/lid; other site 568815004164 ABC transporter signature motif; other site 568815004165 Walker B; other site 568815004166 D-loop; other site 568815004167 H-loop/switch region; other site 568815004168 Putative hemolysin [General function prediction only]; Region: COG3176 568815004169 lipoprotein signal peptidase; Provisional; Region: PRK14795 568815004170 lipoprotein signal peptidase; Provisional; Region: PRK14787 568815004171 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 568815004172 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 568815004173 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 568815004174 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 568815004175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568815004176 S-adenosylmethionine binding site [chemical binding]; other site 568815004177 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 568815004178 IHF dimer interface [polypeptide binding]; other site 568815004179 IHF - DNA interface [nucleotide binding]; other site 568815004180 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 568815004181 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 568815004182 tandem repeat interface [polypeptide binding]; other site 568815004183 oligomer interface [polypeptide binding]; other site 568815004184 active site residues [active] 568815004185 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 568815004186 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 568815004187 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 568815004188 OstA-like protein; Region: OstA; pfam03968 568815004189 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 568815004190 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 568815004191 Walker A/P-loop; other site 568815004192 ATP binding site [chemical binding]; other site 568815004193 Q-loop/lid; other site 568815004194 ABC transporter signature motif; other site 568815004195 Walker B; other site 568815004196 D-loop; other site 568815004197 H-loop/switch region; other site 568815004198 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 568815004199 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 568815004200 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 568815004201 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 568815004202 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 568815004203 30S subunit binding site; other site 568815004204 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568815004205 active site 568815004206 phosphorylation site [posttranslational modification] 568815004207 Uncharacterized small protein [Function unknown]; Region: COG5568 568815004208 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 568815004209 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 568815004210 putative dimer interface [polypeptide binding]; other site 568815004211 Integral membrane protein [Function unknown]; Region: COG5488 568815004212 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 568815004213 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 568815004214 minor groove reading motif; other site 568815004215 helix-hairpin-helix signature motif; other site 568815004216 substrate binding pocket [chemical binding]; other site 568815004217 active site 568815004218 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 568815004219 CysZ-like protein; Reviewed; Region: PRK12768 568815004220 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 568815004221 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 568815004222 substrate binding site [chemical binding]; other site 568815004223 ATP binding site [chemical binding]; other site 568815004224 Predicted membrane protein [Function unknown]; Region: COG2860 568815004225 UPF0126 domain; Region: UPF0126; pfam03458 568815004226 UPF0126 domain; Region: UPF0126; pfam03458 568815004227 heat shock protein GrpE; Provisional; Region: PRK14141 568815004228 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 568815004229 dimer interface [polypeptide binding]; other site 568815004230 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 568815004231 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 568815004232 ribonuclease PH; Reviewed; Region: rph; PRK00173 568815004233 Ribonuclease PH; Region: RNase_PH_bact; cd11362 568815004234 hexamer interface [polypeptide binding]; other site 568815004235 active site 568815004236 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 568815004237 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 568815004238 putative metal binding site [ion binding]; other site 568815004239 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 568815004240 active site 568815004241 dimerization interface [polypeptide binding]; other site 568815004242 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 568815004243 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568815004244 FeS/SAM binding site; other site 568815004245 HemN C-terminal domain; Region: HemN_C; pfam06969 568815004246 Predicted methyltransferases [General function prediction only]; Region: COG0313 568815004247 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 568815004248 putative SAM binding site [chemical binding]; other site 568815004249 putative homodimer interface [polypeptide binding]; other site 568815004250 hypothetical protein; Reviewed; Region: PRK12497 568815004251 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 568815004252 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 568815004253 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 568815004254 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 568815004255 active site 568815004256 SAM binding site [chemical binding]; other site 568815004257 homodimer interface [polypeptide binding]; other site 568815004258 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 568815004259 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 568815004260 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 568815004261 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 568815004262 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 568815004263 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 568815004264 Active Sites [active] 568815004265 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3749 568815004266 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 568815004267 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 568815004268 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 568815004269 active site 568815004270 DNA binding site [nucleotide binding] 568815004271 BA14K-like protein; Region: BA14K; pfam07886 568815004272 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 568815004273 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 568815004274 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 568815004275 substrate binding pocket [chemical binding]; other site 568815004276 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 568815004277 B12 binding site [chemical binding]; other site 568815004278 cobalt ligand [ion binding]; other site 568815004279 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 568815004280 Dehydratase family; Region: ILVD_EDD; cl00340 568815004281 Autoinducer binding domain; Region: Autoind_bind; pfam03472 568815004282 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568815004283 DNA binding residues [nucleotide binding] 568815004284 aminotransferase; Provisional; Region: PRK06105 568815004285 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 568815004286 inhibitor-cofactor binding pocket; inhibition site 568815004287 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568815004288 catalytic residue [active] 568815004289 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 568815004290 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 568815004291 Active Sites [active] 568815004292 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 568815004293 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 568815004294 CysD dimerization site [polypeptide binding]; other site 568815004295 G1 box; other site 568815004296 putative GEF interaction site [polypeptide binding]; other site 568815004297 GTP/Mg2+ binding site [chemical binding]; other site 568815004298 Switch I region; other site 568815004299 G2 box; other site 568815004300 G3 box; other site 568815004301 Switch II region; other site 568815004302 G4 box; other site 568815004303 G5 box; other site 568815004304 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 568815004305 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 568815004306 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 568815004307 ligand-binding site [chemical binding]; other site 568815004308 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 568815004309 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 568815004310 active site 568815004311 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 568815004312 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 568815004313 ligand binding site [chemical binding]; other site 568815004314 flexible hinge region; other site 568815004315 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 568815004316 putative switch regulator; other site 568815004317 non-specific DNA interactions [nucleotide binding]; other site 568815004318 DNA binding site [nucleotide binding] 568815004319 sequence specific DNA binding site [nucleotide binding]; other site 568815004320 putative cAMP binding site [chemical binding]; other site 568815004321 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 568815004322 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 568815004323 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 568815004324 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 568815004325 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 568815004326 GAF domain; Region: GAF; pfam01590 568815004327 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 568815004328 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 568815004329 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 568815004330 NAD(P) binding site [chemical binding]; other site 568815004331 catalytic residues [active] 568815004332 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 568815004333 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 568815004334 NAD binding site [chemical binding]; other site 568815004335 substrate binding site [chemical binding]; other site 568815004336 catalytic Zn binding site [ion binding]; other site 568815004337 tetramer interface [polypeptide binding]; other site 568815004338 structural Zn binding site [ion binding]; other site 568815004339 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564 568815004340 Transcriptional regulators [Transcription]; Region: PurR; COG1609 568815004341 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568815004342 DNA binding site [nucleotide binding] 568815004343 domain linker motif; other site 568815004344 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 568815004345 putative dimerization interface [polypeptide binding]; other site 568815004346 putative ligand binding site [chemical binding]; other site 568815004347 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568815004348 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568815004349 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 568815004350 Walker A/P-loop; other site 568815004351 ATP binding site [chemical binding]; other site 568815004352 Q-loop/lid; other site 568815004353 ABC transporter signature motif; other site 568815004354 Walker B; other site 568815004355 D-loop; other site 568815004356 H-loop/switch region; other site 568815004357 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 568815004358 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 568815004359 NAD(P) binding site [chemical binding]; other site 568815004360 catalytic residues [active] 568815004361 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 568815004362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815004363 dimer interface [polypeptide binding]; other site 568815004364 conserved gate region; other site 568815004365 putative PBP binding loops; other site 568815004366 ABC-ATPase subunit interface; other site 568815004367 Putative transcription activator [Transcription]; Region: TenA; COG0819 568815004368 NMT1/THI5 like; Region: NMT1; pfam09084 568815004369 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 568815004370 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 568815004371 active site 568815004372 thiamine phosphate binding site [chemical binding]; other site 568815004373 pyrophosphate binding site [ion binding]; other site 568815004374 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 568815004375 ThiS interaction site; other site 568815004376 putative active site [active] 568815004377 tetramer interface [polypeptide binding]; other site 568815004378 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 568815004379 thiS-thiF/thiG interaction site; other site 568815004380 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 568815004381 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 568815004382 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 568815004383 dimer interface [polypeptide binding]; other site 568815004384 substrate binding site [chemical binding]; other site 568815004385 ATP binding site [chemical binding]; other site 568815004386 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 568815004387 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 568815004388 putative active site [active] 568815004389 heme pocket [chemical binding]; other site 568815004390 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 568815004391 putative active site [active] 568815004392 heme pocket [chemical binding]; other site 568815004393 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 568815004394 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 568815004395 metal binding site [ion binding]; metal-binding site 568815004396 active site 568815004397 I-site; other site 568815004398 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 568815004399 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 568815004400 metal-binding site [ion binding] 568815004401 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 568815004402 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 568815004403 metal-binding site [ion binding] 568815004404 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568815004405 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 568815004406 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 568815004407 DNA binding residues [nucleotide binding] 568815004408 dimer interface [polypeptide binding]; other site 568815004409 copper binding site [ion binding]; other site 568815004410 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815004411 dimer interface [polypeptide binding]; other site 568815004412 conserved gate region; other site 568815004413 putative PBP binding loops; other site 568815004414 ABC-ATPase subunit interface; other site 568815004415 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 568815004416 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 568815004417 Walker A/P-loop; other site 568815004418 ATP binding site [chemical binding]; other site 568815004419 Q-loop/lid; other site 568815004420 ABC transporter signature motif; other site 568815004421 Walker B; other site 568815004422 D-loop; other site 568815004423 H-loop/switch region; other site 568815004424 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 568815004425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815004426 dimer interface [polypeptide binding]; other site 568815004427 conserved gate region; other site 568815004428 ABC-ATPase subunit interface; other site 568815004429 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 568815004430 Uncharacterized conserved protein [Function unknown]; Region: COG5514 568815004431 heme-binding site [chemical binding]; other site 568815004432 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 568815004433 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 568815004434 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 568815004435 NAD(P) binding site [chemical binding]; other site 568815004436 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 568815004437 hydroxyglutarate oxidase; Provisional; Region: PRK11728 568815004438 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 568815004439 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 568815004440 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 568815004441 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 568815004442 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 568815004443 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 568815004444 Amidohydrolase; Region: Amidohydro_2; pfam04909 568815004445 active site 568815004446 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568815004447 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568815004448 putative DNA binding site [nucleotide binding]; other site 568815004449 putative Zn2+ binding site [ion binding]; other site 568815004450 Bacterial transcriptional regulator; Region: IclR; pfam01614 568815004451 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 568815004452 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 568815004453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815004454 dimer interface [polypeptide binding]; other site 568815004455 conserved gate region; other site 568815004456 putative PBP binding loops; other site 568815004457 ABC-ATPase subunit interface; other site 568815004458 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 568815004459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815004460 dimer interface [polypeptide binding]; other site 568815004461 conserved gate region; other site 568815004462 putative PBP binding loops; other site 568815004463 ABC-ATPase subunit interface; other site 568815004464 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 568815004465 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 568815004466 Walker A/P-loop; other site 568815004467 ATP binding site [chemical binding]; other site 568815004468 Q-loop/lid; other site 568815004469 ABC transporter signature motif; other site 568815004470 Walker B; other site 568815004471 D-loop; other site 568815004472 H-loop/switch region; other site 568815004473 TOBE domain; Region: TOBE_2; pfam08402 568815004474 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 568815004475 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 568815004476 active site pocket [active] 568815004477 Uncharacterized conserved protein [Function unknown]; Region: COG3254 568815004478 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 568815004479 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 568815004480 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 568815004481 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 568815004482 NAD binding site [chemical binding]; other site 568815004483 homotetramer interface [polypeptide binding]; other site 568815004484 homodimer interface [polypeptide binding]; other site 568815004485 active site 568815004486 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 568815004487 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 568815004488 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 568815004489 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 568815004490 putative active site pocket [active] 568815004491 metal binding site [ion binding]; metal-binding site 568815004492 zinc-binding protein; Provisional; Region: PRK01343 568815004493 Maf-like protein; Region: Maf; pfam02545 568815004494 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 568815004495 active site 568815004496 dimer interface [polypeptide binding]; other site 568815004497 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 568815004498 rRNA binding site [nucleotide binding]; other site 568815004499 predicted 30S ribosome binding site; other site 568815004500 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 568815004501 Low molecular weight phosphatase family; Region: LMWPc; cd00115 568815004502 active site 568815004503 hypothetical protein; Provisional; Region: PRK02853 568815004504 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 568815004505 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 568815004506 NAD binding site [chemical binding]; other site 568815004507 dimerization interface [polypeptide binding]; other site 568815004508 product binding site; other site 568815004509 substrate binding site [chemical binding]; other site 568815004510 zinc binding site [ion binding]; other site 568815004511 catalytic residues [active] 568815004512 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 568815004513 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 568815004514 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 568815004515 hinge; other site 568815004516 active site 568815004517 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 568815004518 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 568815004519 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 568815004520 active site 568815004521 DNA binding site [nucleotide binding] 568815004522 Int/Topo IB signature motif; other site 568815004523 Prophage antirepressor [Transcription]; Region: COG3617 568815004524 BRO family, N-terminal domain; Region: Bro-N; smart01040 568815004525 BRO family, N-terminal domain; Region: Bro-N; smart01040 568815004526 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 568815004527 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 568815004528 catalytic residues [active] 568815004529 catalytic nucleophile [active] 568815004530 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 568815004531 DNA-binding interface [nucleotide binding]; DNA binding site 568815004532 BRO family, N-terminal domain; Region: Bro-N; cl10591 568815004533 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568815004534 non-specific DNA binding site [nucleotide binding]; other site 568815004535 salt bridge; other site 568815004536 sequence-specific DNA binding site [nucleotide binding]; other site 568815004537 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 568815004538 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 568815004539 alpha-gamma subunit interface [polypeptide binding]; other site 568815004540 beta-gamma subunit interface [polypeptide binding]; other site 568815004541 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 568815004542 gamma-beta subunit interface [polypeptide binding]; other site 568815004543 alpha-beta subunit interface [polypeptide binding]; other site 568815004544 urease subunit alpha; Reviewed; Region: ureC; PRK13207 568815004545 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 568815004546 subunit interactions [polypeptide binding]; other site 568815004547 active site 568815004548 flap region; other site 568815004549 Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371 568815004550 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 568815004551 dimer interface [polypeptide binding]; other site 568815004552 catalytic residues [active] 568815004553 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 568815004554 UreF; Region: UreF; pfam01730 568815004555 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 568815004556 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568815004557 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568815004558 ATP binding site [chemical binding]; other site 568815004559 Mg2+ binding site [ion binding]; other site 568815004560 G-X-G motif; other site 568815004561 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 568815004562 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 568815004563 HlyD family secretion protein; Region: HlyD_3; pfam13437 568815004564 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 568815004565 phenylhydantoinase; Validated; Region: PRK08323 568815004566 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 568815004567 tetramer interface [polypeptide binding]; other site 568815004568 active site 568815004569 allantoate amidohydrolase; Reviewed; Region: PRK12893 568815004570 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 568815004571 active site 568815004572 metal binding site [ion binding]; metal-binding site 568815004573 dimer interface [polypeptide binding]; other site 568815004574 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 568815004575 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568815004576 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 568815004577 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 568815004578 nudix motif; other site 568815004579 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 568815004580 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 568815004581 homodimer interface [polypeptide binding]; other site 568815004582 active site 568815004583 FMN binding site [chemical binding]; other site 568815004584 substrate binding site [chemical binding]; other site 568815004585 4Fe-4S binding domain; Region: Fer4; cl02805 568815004586 4Fe-4S binding domain; Region: Fer4; pfam00037 568815004587 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 568815004588 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 568815004589 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568815004590 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 568815004591 putative hydrophobic ligand binding site [chemical binding]; other site 568815004592 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 568815004593 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 568815004594 active site 568815004595 dimer interface [polypeptide binding]; other site 568815004596 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 568815004597 dimer interface [polypeptide binding]; other site 568815004598 active site 568815004599 Predicted deacylase [General function prediction only]; Region: COG3608 568815004600 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 568815004601 active site 568815004602 Zn binding site [ion binding]; other site 568815004603 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 568815004604 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568815004605 motif II; other site 568815004606 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 568815004607 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 568815004608 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 568815004609 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 568815004610 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 568815004611 acyl-activating enzyme (AAE) consensus motif; other site 568815004612 putative AMP binding site [chemical binding]; other site 568815004613 putative active site [active] 568815004614 putative CoA binding site [chemical binding]; other site 568815004615 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 568815004616 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568815004617 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 568815004618 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 568815004619 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 568815004620 HlyD family secretion protein; Region: HlyD_3; pfam13437 568815004621 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 568815004622 Protein export membrane protein; Region: SecD_SecF; cl14618 568815004623 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568815004624 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568815004625 substrate binding pocket [chemical binding]; other site 568815004626 membrane-bound complex binding site; other site 568815004627 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 568815004628 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 568815004629 DXD motif; other site 568815004630 Uncharacterized conserved protein [Function unknown]; Region: COG2326 568815004631 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 568815004632 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568815004633 dimer interface [polypeptide binding]; other site 568815004634 phosphorylation site [posttranslational modification] 568815004635 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568815004636 ATP binding site [chemical binding]; other site 568815004637 Mg2+ binding site [ion binding]; other site 568815004638 G-X-G motif; other site 568815004639 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5352 568815004640 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 568815004641 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 568815004642 inhibitor-cofactor binding pocket; inhibition site 568815004643 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568815004644 catalytic residue [active] 568815004645 ornithine carbamoyltransferase; Provisional; Region: PRK00779 568815004646 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 568815004647 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 568815004648 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 568815004649 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 568815004650 dimerization interface [polypeptide binding]; other site 568815004651 domain crossover interface; other site 568815004652 redox-dependent activation switch; other site 568815004653 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 568815004654 O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504 568815004655 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 568815004656 homodimer interface [polypeptide binding]; other site 568815004657 substrate-cofactor binding pocket; other site 568815004658 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568815004659 catalytic residue [active] 568815004660 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 568815004661 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 568815004662 trimer interface [polypeptide binding]; other site 568815004663 active site 568815004664 Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717 568815004665 trimer interface [polypeptide binding]; other site 568815004666 active site 568815004667 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 568815004668 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 568815004669 conserved cys residue [active] 568815004670 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 568815004671 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 568815004672 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 568815004673 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 568815004674 quinone interaction residues [chemical binding]; other site 568815004675 active site 568815004676 catalytic residues [active] 568815004677 FMN binding site [chemical binding]; other site 568815004678 substrate binding site [chemical binding]; other site 568815004679 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 568815004680 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 568815004681 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 568815004682 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 568815004683 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568815004684 active site 568815004685 phosphorylation site [posttranslational modification] 568815004686 intermolecular recognition site; other site 568815004687 dimerization interface [polypeptide binding]; other site 568815004688 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568815004689 DNA binding residues [nucleotide binding] 568815004690 dimerization interface [polypeptide binding]; other site 568815004691 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 568815004692 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 568815004693 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 568815004694 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 568815004695 substrate-cofactor binding pocket; other site 568815004696 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568815004697 catalytic residue [active] 568815004698 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 568815004699 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 568815004700 putative active site [active] 568815004701 putative metal binding site [ion binding]; other site 568815004702 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 568815004703 Glycosyltransferase family 29 (sialyltransferase); Region: Glyco_transf_29; pfam00777 568815004704 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568815004705 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568815004706 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 568815004707 putative dimerization interface [polypeptide binding]; other site 568815004708 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 568815004709 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 568815004710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 568815004711 pantoate--beta-alanine ligase; Region: panC; TIGR00018 568815004712 Pantoate-beta-alanine ligase; Region: PanC; cd00560 568815004713 active site 568815004714 ATP-binding site [chemical binding]; other site 568815004715 pantoate-binding site; other site 568815004716 HXXH motif; other site 568815004717 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 568815004718 active site 568815004719 oligomerization interface [polypeptide binding]; other site 568815004720 metal binding site [ion binding]; metal-binding site 568815004721 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 568815004722 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 568815004723 FAD binding pocket [chemical binding]; other site 568815004724 FAD binding motif [chemical binding]; other site 568815004725 phosphate binding motif [ion binding]; other site 568815004726 beta-alpha-beta structure motif; other site 568815004727 NAD binding pocket [chemical binding]; other site 568815004728 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 568815004729 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 568815004730 dimer interface [polypeptide binding]; other site 568815004731 active site 568815004732 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 568815004733 catalytic residues [active] 568815004734 substrate binding site [chemical binding]; other site 568815004735 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 568815004736 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 568815004737 NAD(P) binding pocket [chemical binding]; other site 568815004738 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 568815004739 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 568815004740 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 568815004741 multidrug efflux protein; Reviewed; Region: PRK01766 568815004742 cation binding site [ion binding]; other site 568815004743 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 568815004744 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 568815004745 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568815004746 active site 568815004747 phosphorylation site [posttranslational modification] 568815004748 intermolecular recognition site; other site 568815004749 dimerization interface [polypeptide binding]; other site 568815004750 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568815004751 DNA binding residues [nucleotide binding] 568815004752 dimerization interface [polypeptide binding]; other site 568815004753 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 568815004754 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 568815004755 DctM-like transporters; Region: DctM; pfam06808 568815004756 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 568815004757 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 568815004758 hypothetical protein; Provisional; Region: PRK11171 568815004759 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 568815004760 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 568815004761 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 568815004762 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 568815004763 active site 568815004764 catalytic site [active] 568815004765 tetramer interface [polypeptide binding]; other site 568815004766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 568815004767 Transthyretin_like. This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase). TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl17222 568815004768 homotetramer interface [polypeptide binding]; other site 568815004769 active site 568815004770 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630 568815004771 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 568815004772 catalytic loop [active] 568815004773 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 568815004774 iron binding site [ion binding]; other site 568815004775 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 568815004776 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 568815004777 Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631 568815004778 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 568815004779 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 568815004780 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 568815004781 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 568815004782 XdhC Rossmann domain; Region: XdhC_C; pfam13478 568815004783 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568815004784 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568815004785 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 568815004786 putative effector binding pocket; other site 568815004787 dimerization interface [polypeptide binding]; other site 568815004788 Predicted membrane protein [Function unknown]; Region: COG3748 568815004789 Protein of unknown function (DUF989); Region: DUF989; pfam06181 568815004790 Cytochrome c; Region: Cytochrom_C; pfam00034 568815004791 guanine deaminase; Provisional; Region: PRK09228 568815004792 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 568815004793 active site 568815004794 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 568815004795 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 568815004796 MOFRL family; Region: MOFRL; pfam05161 568815004797 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 568815004798 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 568815004799 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 568815004800 metal-binding site [ion binding] 568815004801 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568815004802 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568815004803 motif II; other site 568815004804 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 568815004805 FixH; Region: FixH; pfam05751 568815004806 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 568815004807 4Fe-4S binding domain; Region: Fer4_5; pfam12801 568815004808 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 568815004809 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 568815004810 Cytochrome c; Region: Cytochrom_C; pfam00034 568815004811 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 568815004812 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 568815004813 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 568815004814 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 568815004815 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 568815004816 Low-spin heme binding site [chemical binding]; other site 568815004817 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 568815004818 Putative water exit pathway; other site 568815004819 Binuclear center (active site) [active] 568815004820 Putative proton exit pathway; other site 568815004821 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 568815004822 metal binding site 2 [ion binding]; metal-binding site 568815004823 putative DNA binding helix; other site 568815004824 metal binding site 1 [ion binding]; metal-binding site 568815004825 dimer interface [polypeptide binding]; other site 568815004826 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 568815004827 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 568815004828 catalytic residues [active] 568815004829 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 568815004830 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 568815004831 NAD(P) binding site [chemical binding]; other site 568815004832 catalytic residues [active] 568815004833 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 568815004834 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 568815004835 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568815004836 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568815004837 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 568815004838 DNA binding site [nucleotide binding] 568815004839 active site 568815004840 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 568815004841 ArsC family; Region: ArsC; pfam03960 568815004842 putative catalytic residues [active] 568815004843 Predicted membrane protein [Function unknown]; Region: COG4129 568815004844 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 568815004845 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568815004846 putative substrate translocation pore; other site 568815004847 D-galactonate transporter; Region: 2A0114; TIGR00893 568815004848 microcin B17 transporter; Reviewed; Region: PRK11098 568815004849 Putative catalytic domain of uncharacterized bacterial hypothetical proteins similar to insect chitin deacetylase-like proteins; Region: CE4_CDA_like_3; cd10976 568815004850 NodB motif; other site 568815004851 putative active site [active] 568815004852 putative catalytic site [active] 568815004853 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 568815004854 GTP-binding protein Der; Reviewed; Region: PRK00093 568815004855 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 568815004856 G1 box; other site 568815004857 GTP/Mg2+ binding site [chemical binding]; other site 568815004858 Switch I region; other site 568815004859 G2 box; other site 568815004860 Switch II region; other site 568815004861 G3 box; other site 568815004862 G4 box; other site 568815004863 G5 box; other site 568815004864 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 568815004865 G1 box; other site 568815004866 GTP/Mg2+ binding site [chemical binding]; other site 568815004867 Switch I region; other site 568815004868 G2 box; other site 568815004869 G3 box; other site 568815004870 Switch II region; other site 568815004871 G4 box; other site 568815004872 G5 box; other site 568815004873 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 568815004874 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 568815004875 nucleotide binding site [chemical binding]; other site 568815004876 putative NEF/HSP70 interaction site [polypeptide binding]; other site 568815004877 SBD interface [polypeptide binding]; other site 568815004878 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 568815004879 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 568815004880 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336 568815004881 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 568815004882 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 568815004883 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 568815004884 F0F1 ATP synthase subunit B'; Validated; Region: PRK09174 568815004885 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 568815004886 F0F1 ATP synthase subunit B; Validated; Region: PRK09173 568815004887 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 568815004888 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 568815004889 RNA/DNA hybrid binding site [nucleotide binding]; other site 568815004890 active site 568815004891 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 568815004892 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568815004893 FeS/SAM binding site; other site 568815004894 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 568815004895 active site 568815004896 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 568815004897 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 568815004898 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 568815004899 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 568815004900 tandem repeat interface [polypeptide binding]; other site 568815004901 oligomer interface [polypeptide binding]; other site 568815004902 active site residues [active] 568815004903 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 568815004904 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 568815004905 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568815004906 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 568815004907 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 568815004908 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 568815004909 substrate binding pocket [chemical binding]; other site 568815004910 chain length determination region; other site 568815004911 substrate-Mg2+ binding site; other site 568815004912 catalytic residues [active] 568815004913 aspartate-rich region 1; other site 568815004914 active site lid residues [active] 568815004915 aspartate-rich region 2; other site 568815004916 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 568815004917 binding surface 568815004918 TPR motif; other site 568815004919 TPR repeat; Region: TPR_11; pfam13414 568815004920 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 568815004921 binding surface 568815004922 TPR motif; other site 568815004923 TPR repeat; Region: TPR_11; pfam13414 568815004924 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 568815004925 binding surface 568815004926 TPR motif; other site 568815004927 TPR repeat; Region: TPR_11; pfam13414 568815004928 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 568815004929 dimer interface [polypeptide binding]; other site 568815004930 motif 1; other site 568815004931 active site 568815004932 motif 2; other site 568815004933 motif 3; other site 568815004934 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 568815004935 DALR anticodon binding domain; Region: DALR_1; pfam05746 568815004936 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 568815004937 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 568815004938 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 568815004939 FAD binding domain; Region: FAD_binding_4; pfam01565 568815004940 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 568815004941 Predicted transcriptional regulator [Transcription]; Region: COG3905 568815004942 enoyl-CoA hydratase; Provisional; Region: PRK06688 568815004943 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568815004944 substrate binding site [chemical binding]; other site 568815004945 oxyanion hole (OAH) forming residues; other site 568815004946 trimer interface [polypeptide binding]; other site 568815004947 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 568815004948 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 568815004949 active site 568815004950 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 568815004951 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 568815004952 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 568815004953 metal binding site [ion binding]; metal-binding site 568815004954 active site 568815004955 I-site; other site 568815004956 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 568815004957 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 568815004958 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 568815004959 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 568815004960 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 568815004961 UbiA prenyltransferase family; Region: UbiA; pfam01040 568815004962 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 568815004963 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 568815004964 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 568815004965 chaperone protein DnaJ; Provisional; Region: PRK14299 568815004966 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 568815004967 HSP70 interaction site [polypeptide binding]; other site 568815004968 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 568815004969 dimer interface [polypeptide binding]; other site 568815004970 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 568815004971 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 568815004972 NAD binding site [chemical binding]; other site 568815004973 homotetramer interface [polypeptide binding]; other site 568815004974 homodimer interface [polypeptide binding]; other site 568815004975 substrate binding site [chemical binding]; other site 568815004976 active site 568815004977 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568815004978 catalytic core [active] 568815004979 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 568815004980 DNA-binding site [nucleotide binding]; DNA binding site 568815004981 RNA-binding motif; other site 568815004982 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 568815004983 putative acyl-acceptor binding pocket; other site 568815004984 Protein of unknown function (DUF1344); Region: DUF1344; pfam07076 568815004985 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 568815004986 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 568815004987 Tetramer interface [polypeptide binding]; other site 568815004988 active site 568815004989 FMN-binding site [chemical binding]; other site 568815004990 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09314 568815004991 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 568815004992 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 568815004993 dimerization interface [polypeptide binding]; other site 568815004994 active site 568815004995 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 568815004996 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 568815004997 putative active site [active] 568815004998 Zn binding site [ion binding]; other site 568815004999 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 568815005000 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 568815005001 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 568815005002 Predicted membrane protein [Function unknown]; Region: COG2261 568815005003 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3753 568815005004 Pirin-related protein [General function prediction only]; Region: COG1741 568815005005 Pirin; Region: Pirin; pfam02678 568815005006 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 568815005007 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 568815005008 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 568815005009 TPP-binding site; other site 568815005010 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 568815005011 PYR/PP interface [polypeptide binding]; other site 568815005012 dimer interface [polypeptide binding]; other site 568815005013 TPP binding site [chemical binding]; other site 568815005014 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 568815005015 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 568815005016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568815005017 RNA binding surface [nucleotide binding]; other site 568815005018 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568815005019 S-adenosylmethionine binding site [chemical binding]; other site 568815005020 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 568815005021 Methyltransferase domain; Region: Methyltransf_26; pfam13659 568815005022 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 568815005023 Predicted periplasmic protein [General function prediction only]; Region: COG3895 568815005024 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 568815005025 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 568815005026 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 568815005027 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568815005028 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 568815005029 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 568815005030 Walker A/P-loop; other site 568815005031 ATP binding site [chemical binding]; other site 568815005032 Q-loop/lid; other site 568815005033 ABC transporter signature motif; other site 568815005034 Walker B; other site 568815005035 D-loop; other site 568815005036 H-loop/switch region; other site 568815005037 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 568815005038 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 568815005039 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 568815005040 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 568815005041 classical (c) SDRs; Region: SDR_c; cd05233 568815005042 NAD(P) binding site [chemical binding]; other site 568815005043 active site 568815005044 amidophosphoribosyltransferase; Provisional; Region: PRK09123 568815005045 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 568815005046 active site 568815005047 tetramer interface [polypeptide binding]; other site 568815005048 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568815005049 active site 568815005050 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 568815005051 Colicin V production protein; Region: Colicin_V; pfam02674 568815005052 DNA repair protein RadA; Provisional; Region: PRK11823 568815005053 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 568815005054 Walker A motif/ATP binding site; other site 568815005055 ATP binding site [chemical binding]; other site 568815005056 Walker B motif; other site 568815005057 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 568815005058 replicative DNA helicase; Provisional; Region: PRK09165 568815005059 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 568815005060 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 568815005061 Walker A motif; other site 568815005062 ATP binding site [chemical binding]; other site 568815005063 Walker B motif; other site 568815005064 DNA binding loops [nucleotide binding] 568815005065 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 568815005066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568815005067 S-adenosylmethionine binding site [chemical binding]; other site 568815005068 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 568815005069 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 568815005070 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 568815005071 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 568815005072 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 568815005073 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 568815005074 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 568815005075 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936 568815005076 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 568815005077 NAD(P) binding site [chemical binding]; other site 568815005078 homotetramer interface [polypeptide binding]; other site 568815005079 homodimer interface [polypeptide binding]; other site 568815005080 active site 568815005081 acyl carrier protein; Provisional; Region: acpP; PRK00982 568815005082 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 568815005083 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 568815005084 dimer interface [polypeptide binding]; other site 568815005085 active site 568815005086 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 568815005087 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 568815005088 dimerization interface [polypeptide binding]; other site 568815005089 Uncharacterized stress-induced protein [Function unknown]; Region: COG1561 568815005090 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 568815005091 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 568815005092 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 568815005093 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 568815005094 catalytic site [active] 568815005095 G-X2-G-X-G-K; other site 568815005096 protease TldD; Provisional; Region: tldD; PRK10735 568815005097 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 568815005098 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 568815005099 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 568815005100 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 568815005101 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 568815005102 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 568815005103 Subunit I/III interface [polypeptide binding]; other site 568815005104 D-pathway; other site 568815005105 Subunit I/VIIc interface [polypeptide binding]; other site 568815005106 Subunit I/IV interface [polypeptide binding]; other site 568815005107 Subunit I/II interface [polypeptide binding]; other site 568815005108 Low-spin heme (heme a) binding site [chemical binding]; other site 568815005109 Subunit I/VIIa interface [polypeptide binding]; other site 568815005110 Subunit I/VIa interface [polypeptide binding]; other site 568815005111 Dimer interface; other site 568815005112 Putative water exit pathway; other site 568815005113 Binuclear center (heme a3/CuB) [ion binding]; other site 568815005114 K-pathway; other site 568815005115 Subunit I/Vb interface [polypeptide binding]; other site 568815005116 Putative proton exit pathway; other site 568815005117 Subunit I/VIb interface; other site 568815005118 Subunit I/VIc interface [polypeptide binding]; other site 568815005119 Electron transfer pathway; other site 568815005120 Subunit I/VIIIb interface [polypeptide binding]; other site 568815005121 Subunit I/VIIb interface [polypeptide binding]; other site 568815005122 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 568815005123 UbiA prenyltransferase family; Region: UbiA; pfam01040 568815005124 Cytochrome oxidase assembly factor [Posttranslational modification, protein turnover, chaperones]; Region: COX11; COG3175 568815005125 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 568815005126 Subunit III/VIIa interface [polypeptide binding]; other site 568815005127 Phospholipid binding site [chemical binding]; other site 568815005128 Subunit I/III interface [polypeptide binding]; other site 568815005129 Subunit III/VIb interface [polypeptide binding]; other site 568815005130 Subunit III/VIa interface; other site 568815005131 Subunit III/Vb interface [polypeptide binding]; other site 568815005132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 568815005133 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 568815005134 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 568815005135 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 568815005136 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 568815005137 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 568815005138 putative active site [active] 568815005139 putative substrate binding site [chemical binding]; other site 568815005140 ATP binding site [chemical binding]; other site 568815005141 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 568815005142 RNA/DNA hybrid binding site [nucleotide binding]; other site 568815005143 active site 568815005144 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 568815005145 catalytic triad [active] 568815005146 dimer interface [polypeptide binding]; other site 568815005147 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 568815005148 hypothetical protein; Validated; Region: PRK00228 568815005149 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 568815005150 PAS fold; Region: PAS_3; pfam08447 568815005151 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 568815005152 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 568815005153 metal binding site [ion binding]; metal-binding site 568815005154 active site 568815005155 I-site; other site 568815005156 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 568815005157 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 568815005158 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 568815005159 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 568815005160 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 568815005161 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 568815005162 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 568815005163 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 568815005164 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568815005165 catalytic residue [active] 568815005166 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 568815005167 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 568815005168 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 568815005169 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 568815005170 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568815005171 active site 568815005172 motif I; other site 568815005173 motif II; other site 568815005174 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 568815005175 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 568815005176 Cl- selectivity filter; other site 568815005177 Cl- binding residues [ion binding]; other site 568815005178 pore gating glutamate residue; other site 568815005179 dimer interface [polypeptide binding]; other site 568815005180 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 568815005181 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 568815005182 DNA methylase; Region: N6_N4_Mtase; pfam01555 568815005183 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 568815005184 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568815005185 motif II; other site 568815005186 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 568815005187 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 568815005188 minor groove reading motif; other site 568815005189 helix-hairpin-helix signature motif; other site 568815005190 substrate binding pocket [chemical binding]; other site 568815005191 active site 568815005192 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 568815005193 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 568815005194 DNA binding and oxoG recognition site [nucleotide binding] 568815005195 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5389 568815005196 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 568815005197 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 568815005198 catalytic residues [active] 568815005199 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 568815005200 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 568815005201 Walker A/P-loop; other site 568815005202 ATP binding site [chemical binding]; other site 568815005203 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 568815005204 ABC transporter signature motif; other site 568815005205 Walker B; other site 568815005206 D-loop; other site 568815005207 H-loop/switch region; other site 568815005208 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 568815005209 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 568815005210 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 568815005211 pyruvate phosphate dikinase; Provisional; Region: PRK09279 568815005212 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 568815005213 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 568815005214 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 568815005215 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 568815005216 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 568815005217 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 568815005218 ureidoglycolate hydrolase; Provisional; Region: PRK03606 568815005219 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 568815005220 active site 568815005221 homotetramer interface [polypeptide binding]; other site 568815005222 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 568815005223 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 568815005224 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 568815005225 NAD(P) binding site [chemical binding]; other site 568815005226 homodimer interface [polypeptide binding]; other site 568815005227 substrate binding site [chemical binding]; other site 568815005228 active site 568815005229 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 568815005230 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 568815005231 Mg++ binding site [ion binding]; other site 568815005232 putative catalytic motif [active] 568815005233 putative substrate binding site [chemical binding]; other site 568815005234 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 568815005235 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568815005236 Homeodomain-like domain; Region: HTH_23; cl17451 568815005237 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 568815005238 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 568815005239 Integrase core domain; Region: rve; pfam00665 568815005240 Integrase core domain; Region: rve_3; pfam13683 568815005241 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 568815005242 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 568815005243 active site 568815005244 substrate binding site [chemical binding]; other site 568815005245 cosubstrate binding site; other site 568815005246 catalytic site [active] 568815005247 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 568815005248 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 568815005249 Walker A/P-loop; other site 568815005250 ATP binding site [chemical binding]; other site 568815005251 Q-loop/lid; other site 568815005252 ABC transporter signature motif; other site 568815005253 Walker B; other site 568815005254 D-loop; other site 568815005255 H-loop/switch region; other site 568815005256 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 568815005257 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 568815005258 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 568815005259 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 568815005260 inhibitor-cofactor binding pocket; inhibition site 568815005261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568815005262 catalytic residue [active] 568815005263 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 568815005264 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 568815005265 NADP-binding site; other site 568815005266 homotetramer interface [polypeptide binding]; other site 568815005267 substrate binding site [chemical binding]; other site 568815005268 homodimer interface [polypeptide binding]; other site 568815005269 active site 568815005270 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 568815005271 Integrase core domain; Region: rve; pfam00665 568815005272 DDE domain; Region: DDE_Tnp_IS240; pfam13610 568815005273 Integrase core domain; Region: rve_3; pfam13683 568815005274 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 568815005275 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 568815005276 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568815005277 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568815005278 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 568815005279 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 568815005280 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568815005281 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 568815005282 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568815005283 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 568815005284 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 568815005285 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 568815005286 active site 568815005287 substrate binding site [chemical binding]; other site 568815005288 metal binding site [ion binding]; metal-binding site 568815005289 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 568815005290 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 568815005291 Substrate binding site; other site 568815005292 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 568815005293 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 568815005294 dimerization interface [polypeptide binding]; other site 568815005295 putative active cleft [active] 568815005296 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568815005297 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 568815005298 putative ADP-binding pocket [chemical binding]; other site 568815005299 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 568815005300 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 568815005301 Walker A/P-loop; other site 568815005302 ATP binding site [chemical binding]; other site 568815005303 Q-loop/lid; other site 568815005304 ABC transporter signature motif; other site 568815005305 Walker B; other site 568815005306 D-loop; other site 568815005307 H-loop/switch region; other site 568815005308 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 568815005309 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568815005310 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 568815005311 TM-ABC transporter signature motif; other site 568815005312 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 568815005313 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311 568815005314 putative ligand binding site [chemical binding]; other site 568815005315 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 568815005316 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 568815005317 Metal-binding active site; metal-binding site 568815005318 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 568815005319 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 568815005320 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 568815005321 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 568815005322 xylose isomerase; Provisional; Region: PRK05474 568815005323 xylose isomerase; Region: xylose_isom_A; TIGR02630 568815005324 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 568815005325 N- and C-terminal domain interface [polypeptide binding]; other site 568815005326 D-xylulose kinase; Region: XylB; TIGR01312 568815005327 active site 568815005328 MgATP binding site [chemical binding]; other site 568815005329 catalytic site [active] 568815005330 metal binding site [ion binding]; metal-binding site 568815005331 xylulose binding site [chemical binding]; other site 568815005332 homodimer interface [polypeptide binding]; other site 568815005333 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568815005334 DNA binding site [nucleotide binding] 568815005335 domain linker motif; other site 568815005336 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 568815005337 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 568815005338 putative ligand binding site [chemical binding]; other site 568815005339 Helix-turn-helix domain; Region: HTH_18; pfam12833 568815005340 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568815005341 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 568815005342 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 568815005343 tetrameric interface [polypeptide binding]; other site 568815005344 NAD binding site [chemical binding]; other site 568815005345 catalytic residues [active] 568815005346 choline dehydrogenase; Validated; Region: PRK02106 568815005347 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 568815005348 transcriptional regulator BetI; Validated; Region: PRK00767 568815005349 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568815005350 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 568815005351 transcription elongation factor regulatory protein; Validated; Region: PRK06342 568815005352 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 568815005353 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 568815005354 putative addiction module antidote; Region: doc_partner; TIGR02609 568815005355 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 568815005356 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 568815005357 Cl binding site [ion binding]; other site 568815005358 oligomer interface [polypeptide binding]; other site 568815005359 Transcriptional regulators [Transcription]; Region: FadR; COG2186 568815005360 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568815005361 DNA-binding site [nucleotide binding]; DNA binding site 568815005362 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 568815005363 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 568815005364 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568815005365 putative substrate translocation pore; other site 568815005366 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 568815005367 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 568815005368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 568815005369 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 568815005370 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 568815005371 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568815005372 motif II; other site 568815005373 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 568815005374 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 568815005375 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 568815005376 potential protein location (hypothetical protein) that overlaps protein (hypothetical membrane-spanning protein) 568815005377 potential protein location (hypothetical membrane-spanning protein) that overlaps protein (hypothetical protein) 568815005378 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 568815005379 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 568815005380 Predicted transcriptional regulator [Transcription]; Region: COG4957 568815005381 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 568815005382 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 568815005383 DnaA box-binding interface [nucleotide binding]; other site 568815005384 amidase; Validated; Region: PRK05962 568815005385 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 568815005386 Flavin Reductases; Region: FlaRed; cl00801 568815005387 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 568815005388 putative active site [active] 568815005389 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568815005390 heme pocket [chemical binding]; other site 568815005391 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568815005392 dimer interface [polypeptide binding]; other site 568815005393 phosphorylation site [posttranslational modification] 568815005394 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568815005395 ATP binding site [chemical binding]; other site 568815005396 Mg2+ binding site [ion binding]; other site 568815005397 G-X-G motif; other site 568815005398 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 568815005399 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 568815005400 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 568815005401 Uncharacterized conserved protein [Function unknown]; Region: COG5447 568815005402 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 568815005403 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 568815005404 Predicted integral membrane protein [Function unknown]; Region: COG5436 568815005405 Uncharacterized conserved protein [Function unknown]; Region: COG5402 568815005406 Transglycosylase; Region: Transgly; pfam00912 568815005407 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 568815005408 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 568815005409 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 568815005410 Uncharacterized conserved protein [Function unknown]; Region: COG5323 568815005411 Terminase-like family; Region: Terminase_6; pfam03237 568815005412 Phage-related protein [Function unknown]; Region: COG4695 568815005413 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 568815005414 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 568815005415 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 568815005416 Phage capsid family; Region: Phage_capsid; pfam05065 568815005417 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 568815005418 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 568815005419 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 568815005420 oligomerization interface [polypeptide binding]; other site 568815005421 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 568815005422 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 568815005423 Predicted secreted protein [Function unknown]; Region: COG5437 568815005424 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 568815005425 phage conserved hypothetical protein; Region: phage_TIGR02216 568815005426 Phage-related minor tail protein [Function unknown]; Region: COG5281 568815005427 TIGR02217 family protein; Region: chp_TIGR02217 568815005428 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 568815005429 phage conserved hypothetical protein BR0599; Region: phg_TIGR02218 568815005430 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 568815005431 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 568815005432 putative phage cell wall peptidase, NlpC/P60 family; Region: phage_NlpC_fam; TIGR02219 568815005433 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 568815005434 Putative phage tail protein; Region: Phage-tail_3; pfam13550 568815005435 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568815005436 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568815005437 active site 568815005438 phosphorylation site [posttranslational modification] 568815005439 intermolecular recognition site; other site 568815005440 dimerization interface [polypeptide binding]; other site 568815005441 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568815005442 DNA binding site [nucleotide binding] 568815005443 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568815005444 HAMP domain; Region: HAMP; pfam00672 568815005445 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568815005446 ATP binding site [chemical binding]; other site 568815005447 Mg2+ binding site [ion binding]; other site 568815005448 G-X-G motif; other site 568815005449 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 568815005450 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 568815005451 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 568815005452 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 568815005453 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 568815005454 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 568815005455 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 568815005456 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 568815005457 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 568815005458 protein binding site [polypeptide binding]; other site 568815005459 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 568815005460 protein binding site [polypeptide binding]; other site 568815005461 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568815005462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568815005463 active site 568815005464 phosphorylation site [posttranslational modification] 568815005465 intermolecular recognition site; other site 568815005466 dimerization interface [polypeptide binding]; other site 568815005467 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568815005468 DNA binding site [nucleotide binding] 568815005469 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568815005470 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 568815005471 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 568815005472 dimerization interface [polypeptide binding]; other site 568815005473 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568815005474 dimer interface [polypeptide binding]; other site 568815005475 phosphorylation site [posttranslational modification] 568815005476 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568815005477 ATP binding site [chemical binding]; other site 568815005478 Mg2+ binding site [ion binding]; other site 568815005479 G-X-G motif; other site 568815005480 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 568815005481 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 568815005482 metal binding triad; other site 568815005483 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 568815005484 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 568815005485 metal binding triad; other site 568815005486 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 568815005487 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 568815005488 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298 568815005489 O-Antigen ligase; Region: Wzy_C; pfam04932 568815005490 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 568815005491 PAS fold; Region: PAS_3; pfam08447 568815005492 putative active site [active] 568815005493 heme pocket [chemical binding]; other site 568815005494 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 568815005495 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568815005496 dimer interface [polypeptide binding]; other site 568815005497 phosphorylation site [posttranslational modification] 568815005498 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568815005499 ATP binding site [chemical binding]; other site 568815005500 Mg2+ binding site [ion binding]; other site 568815005501 G-X-G motif; other site 568815005502 aminopeptidase N; Provisional; Region: pepN; PRK14015 568815005503 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 568815005504 active site 568815005505 Zn binding site [ion binding]; other site 568815005506 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 568815005507 EamA-like transporter family; Region: EamA; pfam00892 568815005508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568815005509 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568815005510 putative substrate translocation pore; other site 568815005511 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 568815005512 Fe-S cluster binding site [ion binding]; other site 568815005513 active site 568815005514 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 568815005515 hydroxyglutarate oxidase; Provisional; Region: PRK11728 568815005516 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 568815005517 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3021 568815005518 putative catalytic site [active] 568815005519 putative metal binding site [ion binding]; other site 568815005520 putative phosphate binding site [ion binding]; other site 568815005521 AMP nucleosidase; Provisional; Region: PRK08292 568815005522 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 568815005523 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 568815005524 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 568815005525 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 568815005526 C-terminal domain interface [polypeptide binding]; other site 568815005527 GSH binding site (G-site) [chemical binding]; other site 568815005528 dimer interface [polypeptide binding]; other site 568815005529 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 568815005530 N-terminal domain interface [polypeptide binding]; other site 568815005531 putative dimer interface [polypeptide binding]; other site 568815005532 active site 568815005533 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4731 568815005534 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 568815005535 Uncharacterized conserved protein [Function unknown]; Region: COG1284 568815005536 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 568815005537 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 568815005538 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 568815005539 histidinol-phosphate aminotransferase; Provisional; Region: PRK08153 568815005540 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568815005541 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568815005542 homodimer interface [polypeptide binding]; other site 568815005543 catalytic residue [active] 568815005544 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 568815005545 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 568815005546 active site 568815005547 DNA binding site [nucleotide binding] 568815005548 Int/Topo IB signature motif; other site 568815005549 Porin subfamily; Region: Porin_2; pfam02530 568815005550 Porin subfamily; Region: Porin_2; pfam02530 568815005551 Uncharacterized conserved protein [Function unknown]; Region: COG3743 568815005552 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 568815005553 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 568815005554 N-acetyl-D-glucosamine binding site [chemical binding]; other site 568815005555 catalytic residue [active] 568815005556 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 568815005557 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 568815005558 dimer interface [polypeptide binding]; other site 568815005559 active site 568815005560 catalytic residue [active] 568815005561 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 568815005562 SmpB-tmRNA interface; other site 568815005563 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 568815005564 Fe-S cluster binding site [ion binding]; other site 568815005565 DNA binding site [nucleotide binding] 568815005566 active site 568815005567 Uncharacterized conserved protein [Function unknown]; Region: COG1432 568815005568 LabA_like proteins; Region: LabA; cd10911 568815005569 putative metal binding site [ion binding]; other site 568815005570 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 568815005571 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 568815005572 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 568815005573 Zn2+ binding site [ion binding]; other site 568815005574 Mg2+ binding site [ion binding]; other site 568815005575 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 568815005576 synthetase active site [active] 568815005577 NTP binding site [chemical binding]; other site 568815005578 metal binding site [ion binding]; metal-binding site 568815005579 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 568815005580 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 568815005581 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568815005582 active site 568815005583 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 568815005584 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 568815005585 ligand binding site [chemical binding]; other site 568815005586 flexible hinge region; other site 568815005587 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 568815005588 putative switch regulator; other site 568815005589 non-specific DNA interactions [nucleotide binding]; other site 568815005590 DNA binding site [nucleotide binding] 568815005591 sequence specific DNA binding site [nucleotide binding]; other site 568815005592 putative cAMP binding site [chemical binding]; other site 568815005593 coproporphyrinogen III oxidase; Provisional; Region: PRK13347 568815005594 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568815005595 FeS/SAM binding site; other site 568815005596 HemN C-terminal domain; Region: HemN_C; pfam06969 568815005597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568815005598 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568815005599 putative substrate translocation pore; other site 568815005600 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 568815005601 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568815005602 Helix-turn-helix domain; Region: HTH_18; pfam12833 568815005603 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3216 568815005604 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 568815005605 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 568815005606 Catalytic site [active] 568815005607 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 568815005608 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 568815005609 ribonuclease III; Reviewed; Region: PRK12371 568815005610 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 568815005611 dimerization interface [polypeptide binding]; other site 568815005612 active site 568815005613 metal binding site [ion binding]; metal-binding site 568815005614 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 568815005615 dsRNA binding site [nucleotide binding]; other site 568815005616 GTPase Era; Reviewed; Region: era; PRK00089 568815005617 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 568815005618 G1 box; other site 568815005619 GTP/Mg2+ binding site [chemical binding]; other site 568815005620 Switch I region; other site 568815005621 G2 box; other site 568815005622 Switch II region; other site 568815005623 G3 box; other site 568815005624 G4 box; other site 568815005625 G5 box; other site 568815005626 KH domain; Region: KH_2; pfam07650 568815005627 Recombination protein O N terminal; Region: RecO_N; pfam11967 568815005628 DNA repair protein RecO; Region: reco; TIGR00613 568815005629 Recombination protein O C terminal; Region: RecO_C; pfam02565 568815005630 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 568815005631 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 568815005632 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 568815005633 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 568815005634 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 568815005635 dihydroorotase; Validated; Region: PRK09060 568815005636 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 568815005637 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 568815005638 active site 568815005639 TIGR02301 family protein; Region: TIGR02301 568815005640 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 568815005641 nudix motif; other site 568815005642 Uncharacterized conserved protein [Function unknown]; Region: COG2135 568815005643 Lysine efflux permease [General function prediction only]; Region: COG1279 568815005644 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 568815005645 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 568815005646 active site 568815005647 HIGH motif; other site 568815005648 nucleotide binding site [chemical binding]; other site 568815005649 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 568815005650 KMSKS motif; other site 568815005651 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 568815005652 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 568815005653 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 568815005654 active site 568815005655 catalytic residues [active] 568815005656 metal binding site [ion binding]; metal-binding site 568815005657 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 568815005658 Predicted permeases [General function prediction only]; Region: RarD; COG2962 568815005659 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 568815005660 Peptidase family M23; Region: Peptidase_M23; pfam01551 568815005661 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 568815005662 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568815005663 S-adenosylmethionine binding site [chemical binding]; other site 568815005664 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 568815005665 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 568815005666 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 568815005667 SurA N-terminal domain; Region: SurA_N; pfam09312 568815005668 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 568815005669 OstA-like protein; Region: OstA; cl00844 568815005670 Organic solvent tolerance protein; Region: OstA_C; pfam04453 568815005671 Predicted permeases [General function prediction only]; Region: COG0795 568815005672 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 568815005673 Predicted permeases [General function prediction only]; Region: COG0795 568815005674 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 568815005675 multifunctional aminopeptidase A; Provisional; Region: PRK00913 568815005676 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 568815005677 interface (dimer of trimers) [polypeptide binding]; other site 568815005678 Substrate-binding/catalytic site; other site 568815005679 Zn-binding sites [ion binding]; other site 568815005680 DNA polymerase III subunit chi; Validated; Region: PRK05728 568815005681 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 568815005682 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568815005683 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568815005684 Walker A/P-loop; other site 568815005685 ATP binding site [chemical binding]; other site 568815005686 ABC transporter signature motif; other site 568815005687 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568815005688 Walker B; other site 568815005689 D-loop; other site 568815005690 ABC transporter; Region: ABC_tran_2; pfam12848 568815005691 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568815005692 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 568815005693 DinB superfamily; Region: DinB_2; pfam12867 568815005694 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 568815005695 active site 568815005696 multimer interface [polypeptide binding]; other site 568815005697 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 568815005698 Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187 568815005699 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 568815005700 MoaE homodimer interface [polypeptide binding]; other site 568815005701 MoaD interaction [polypeptide binding]; other site 568815005702 active site residues [active] 568815005703 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 568815005704 MoaE interaction surface [polypeptide binding]; other site 568815005705 MoeB interaction surface [polypeptide binding]; other site 568815005706 thiocarboxylated glycine; other site 568815005707 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 568815005708 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 568815005709 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 568815005710 GIY-YIG motif/motif A; other site 568815005711 active site 568815005712 catalytic site [active] 568815005713 putative DNA binding site [nucleotide binding]; other site 568815005714 metal binding site [ion binding]; metal-binding site 568815005715 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 568815005716 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 568815005717 short chain dehydrogenase; Provisional; Region: PRK09134 568815005718 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568815005719 NAD(P) binding site [chemical binding]; other site 568815005720 active site 568815005721 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 568815005722 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 568815005723 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 568815005724 putative C-terminal domain interface [polypeptide binding]; other site 568815005725 putative GSH binding site (G-site) [chemical binding]; other site 568815005726 putative dimer interface [polypeptide binding]; other site 568815005727 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 568815005728 dimer interface [polypeptide binding]; other site 568815005729 N-terminal domain interface [polypeptide binding]; other site 568815005730 putative substrate binding pocket (H-site) [chemical binding]; other site 568815005731 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 568815005732 B1 nucleotide binding pocket [chemical binding]; other site 568815005733 B2 nucleotide binding pocket [chemical binding]; other site 568815005734 CAS motifs; other site 568815005735 active site 568815005736 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 568815005737 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 568815005738 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 568815005739 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 568815005740 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 568815005741 putative [4Fe-4S] binding site [ion binding]; other site 568815005742 putative molybdopterin cofactor binding site [chemical binding]; other site 568815005743 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 568815005744 putative molybdopterin cofactor binding site; other site 568815005745 Protein of unknown function (DUF992); Region: DUF992; pfam06186 568815005746 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 568815005747 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 568815005748 active site 568815005749 cosubstrate binding site; other site 568815005750 substrate binding site [chemical binding]; other site 568815005751 catalytic site [active] 568815005752 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 568815005753 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 568815005754 dimerization interface [polypeptide binding]; other site 568815005755 putative ATP binding site [chemical binding]; other site 568815005756 Domain of unknown function DUF20; Region: UPF0118; pfam01594 568815005757 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 568815005758 hypothetical protein; Validated; Region: PRK09087 568815005759 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 568815005760 Walker A motif; other site 568815005761 ATP binding site [chemical binding]; other site 568815005762 Walker B motif; other site 568815005763 arginine finger; other site 568815005764 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568815005765 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 568815005766 NAD(P) binding site [chemical binding]; other site 568815005767 active site 568815005768 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 568815005769 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 568815005770 putative NAD(P) binding site [chemical binding]; other site 568815005771 putative active site [active] 568815005772 L-lactate permease; Region: Lactate_perm; cl00701 568815005773 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 568815005774 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 568815005775 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 568815005776 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 568815005777 active site 568815005778 catalytic site [active] 568815005779 substrate binding site [chemical binding]; other site 568815005780 Archaeal adenylate kinase [Nucleotide transport and metabolism]; Region: AdkA; COG2019 568815005781 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568815005782 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568815005783 non-specific DNA binding site [nucleotide binding]; other site 568815005784 salt bridge; other site 568815005785 sequence-specific DNA binding site [nucleotide binding]; other site 568815005786 Uncharacterized conserved protein [Function unknown]; Region: COG4933 568815005787 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 568815005788 Integrase core domain; Region: rve; pfam00665 568815005789 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 568815005790 AAA domain; Region: AAA_22; pfam13401 568815005791 AAA ATPase domain; Region: AAA_16; pfam13191 568815005792 TniQ; Region: TniQ; pfam06527 568815005793 Uncharacterized protein containing a TIR (Toll-Interleukin 1-resistance) domain [Function unknown]; Region: COG4916 568815005794 TIR domain; Region: TIR_2; pfam13676 568815005795 Bacterial SH3 domain; Region: SH3_3; pfam08239 568815005796 cystathionine beta-lyase; Provisional; Region: PRK05967 568815005797 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 568815005798 homodimer interface [polypeptide binding]; other site 568815005799 substrate-cofactor binding pocket; other site 568815005800 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568815005801 catalytic residue [active] 568815005802 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 568815005803 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 568815005804 active site 568815005805 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 568815005806 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568815005807 substrate binding pocket [chemical binding]; other site 568815005808 membrane-bound complex binding site; other site 568815005809 hinge residues; other site 568815005810 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 568815005811 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815005812 conserved gate region; other site 568815005813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815005814 putative PBP binding loops; other site 568815005815 dimer interface [polypeptide binding]; other site 568815005816 ABC-ATPase subunit interface; other site 568815005817 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568815005818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815005819 dimer interface [polypeptide binding]; other site 568815005820 conserved gate region; other site 568815005821 putative PBP binding loops; other site 568815005822 ABC-ATPase subunit interface; other site 568815005823 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 568815005824 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 568815005825 Walker A/P-loop; other site 568815005826 ATP binding site [chemical binding]; other site 568815005827 Q-loop/lid; other site 568815005828 ABC transporter signature motif; other site 568815005829 Walker B; other site 568815005830 D-loop; other site 568815005831 H-loop/switch region; other site 568815005832 salicylate hydroxylase; Provisional; Region: PRK06475 568815005833 salicylate hydroxylase; Provisional; Region: PRK08163 568815005834 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 568815005835 polyphosphate kinase; Provisional; Region: PRK05443 568815005836 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 568815005837 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 568815005838 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 568815005839 putative domain interface [polypeptide binding]; other site 568815005840 putative active site [active] 568815005841 catalytic site [active] 568815005842 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 568815005843 putative domain interface [polypeptide binding]; other site 568815005844 putative active site [active] 568815005845 catalytic site [active] 568815005846 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 568815005847 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 568815005848 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 568815005849 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 568815005850 catalytic site [active] 568815005851 putative active site [active] 568815005852 putative substrate binding site [chemical binding]; other site 568815005853 HRDC domain; Region: HRDC; pfam00570 568815005854 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 568815005855 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 568815005856 dimer interface [polypeptide binding]; other site 568815005857 anticodon binding site; other site 568815005858 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 568815005859 homodimer interface [polypeptide binding]; other site 568815005860 motif 1; other site 568815005861 active site 568815005862 motif 2; other site 568815005863 GAD domain; Region: GAD; pfam02938 568815005864 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 568815005865 active site 568815005866 motif 3; other site 568815005867 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 568815005868 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 568815005869 CAP-like domain; other site 568815005870 active site 568815005871 primary dimer interface [polypeptide binding]; other site 568815005872 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568815005873 Putative arginyl-tRNA:protein arginylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG2935 568815005874 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 568815005875 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 568815005876 Predicted membrane protein/domain [Function unknown]; Region: COG1714 568815005877 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 568815005878 dimer interface [polypeptide binding]; other site 568815005879 allosteric magnesium binding site [ion binding]; other site 568815005880 active site 568815005881 aspartate-rich active site metal binding site; other site 568815005882 Schiff base residues; other site 568815005883 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 568815005884 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568815005885 substrate binding site [chemical binding]; other site 568815005886 oxyanion hole (OAH) forming residues; other site 568815005887 trimer interface [polypeptide binding]; other site 568815005888 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 568815005889 Transcriptional regulators [Transcription]; Region: MarR; COG1846 568815005890 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 568815005891 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 568815005892 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 568815005893 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 568815005894 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 568815005895 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 568815005896 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 568815005897 dimer interface [polypeptide binding]; other site 568815005898 active site 568815005899 glycine-pyridoxal phosphate binding site [chemical binding]; other site 568815005900 folate binding site [chemical binding]; other site 568815005901 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 568815005902 ATP cone domain; Region: ATP-cone; pfam03477 568815005903 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 568815005904 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 568815005905 catalytic motif [active] 568815005906 Zn binding site [ion binding]; other site 568815005907 RibD C-terminal domain; Region: RibD_C; cl17279 568815005908 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 568815005909 Lumazine binding domain; Region: Lum_binding; pfam00677 568815005910 Lumazine binding domain; Region: Lum_binding; pfam00677 568815005911 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 568815005912 homopentamer interface [polypeptide binding]; other site 568815005913 active site 568815005914 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 568815005915 putative RNA binding site [nucleotide binding]; other site 568815005916 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; COG3808 568815005917 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 568815005918 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 568815005919 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 568815005920 Uncharacterized conserved protein [Function unknown]; Region: COG5452 568815005921 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 568815005922 putative phosphate acyltransferase; Provisional; Region: PRK05331 568815005923 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 568815005924 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 568815005925 dimer interface [polypeptide binding]; other site 568815005926 active site 568815005927 CoA binding pocket [chemical binding]; other site 568815005928 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 568815005929 IHF dimer interface [polypeptide binding]; other site 568815005930 IHF - DNA interface [nucleotide binding]; other site 568815005931 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 568815005932 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 568815005933 DNA binding residues [nucleotide binding] 568815005934 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 568815005935 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 568815005936 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 568815005937 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 568815005938 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 568815005939 SLBB domain; Region: SLBB; pfam10531 568815005940 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 568815005941 Protein of unknown function (DUF2842); Region: DUF2842; pfam11003 568815005942 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 568815005943 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568815005944 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 568815005945 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 568815005946 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 568815005947 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 568815005948 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 568815005949 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 568815005950 oligomer interface [polypeptide binding]; other site 568815005951 putative active site [active] 568815005952 Mn binding site [ion binding]; other site 568815005953 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 568815005954 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 568815005955 23S rRNA interface [nucleotide binding]; other site 568815005956 L3 interface [polypeptide binding]; other site 568815005957 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 568815005958 CoenzymeA binding site [chemical binding]; other site 568815005959 subunit interaction site [polypeptide binding]; other site 568815005960 PHB binding site; other site 568815005961 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 568815005962 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 568815005963 homodimer interface [polypeptide binding]; other site 568815005964 substrate-cofactor binding pocket; other site 568815005965 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568815005966 catalytic residue [active] 568815005967 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 568815005968 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 568815005969 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 568815005970 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 568815005971 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 568815005972 NADH dehydrogenase subunit D; Validated; Region: PRK06075 568815005973 NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905 568815005974 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 568815005975 putative dimer interface [polypeptide binding]; other site 568815005976 [2Fe-2S] cluster binding site [ion binding]; other site 568815005977 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 568815005978 SLBB domain; Region: SLBB; pfam10531 568815005979 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 568815005980 NADH dehydrogenase subunit G; Validated; Region: PRK09130 568815005981 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 568815005982 catalytic loop [active] 568815005983 iron binding site [ion binding]; other site 568815005984 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 568815005985 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 568815005986 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 568815005987 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 568815005988 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 568815005989 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 568815005990 4Fe-4S binding domain; Region: Fer4; pfam00037 568815005991 4Fe-4S binding domain; Region: Fer4; pfam00037 568815005992 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 568815005993 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 568815005994 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 568815005995 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 568815005996 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 568815005997 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 568815005998 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 568815005999 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 568815006000 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 568815006001 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 568815006002 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 568815006003 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 568815006004 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 568815006005 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 568815006006 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 568815006007 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 568815006008 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 568815006009 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 568815006010 dimer interface [polypeptide binding]; other site 568815006011 substrate binding site [chemical binding]; other site 568815006012 metal binding site [ion binding]; metal-binding site 568815006013 Predicted secreted protein [Function unknown]; Region: COG5454 568815006014 prolyl-tRNA synthetase; Provisional; Region: PRK12325 568815006015 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 568815006016 dimer interface [polypeptide binding]; other site 568815006017 motif 1; other site 568815006018 active site 568815006019 motif 2; other site 568815006020 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 568815006021 active site 568815006022 motif 3; other site 568815006023 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 568815006024 anticodon binding site; other site 568815006025 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 568815006026 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 568815006027 FtsX-like permease family; Region: FtsX; pfam02687 568815006028 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568815006029 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 568815006030 Walker A/P-loop; other site 568815006031 ATP binding site [chemical binding]; other site 568815006032 Q-loop/lid; other site 568815006033 ABC transporter signature motif; other site 568815006034 Walker B; other site 568815006035 D-loop; other site 568815006036 H-loop/switch region; other site 568815006037 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 568815006038 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 568815006039 putative active site [active] 568815006040 putative PHP Thumb interface [polypeptide binding]; other site 568815006041 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 568815006042 generic binding surface II; other site 568815006043 generic binding surface I; other site 568815006044 Protein of unknwon function (DUF3008); Region: DUF3008; pfam11450 568815006045 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 568815006046 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 568815006047 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 568815006048 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 568815006049 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568815006050 RNA binding surface [nucleotide binding]; other site 568815006051 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 568815006052 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 568815006053 Ligand Binding Site [chemical binding]; other site 568815006054 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 568815006055 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 568815006056 active site 568815006057 putative lithium-binding site [ion binding]; other site 568815006058 substrate binding site [chemical binding]; other site 568815006059 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 568815006060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568815006061 putative substrate translocation pore; other site 568815006062 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 568815006063 putative GSH binding site [chemical binding]; other site 568815006064 catalytic residues [active] 568815006065 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 568815006066 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 568815006067 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 568815006068 dimerization interface [polypeptide binding]; other site 568815006069 ATP binding site [chemical binding]; other site 568815006070 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 568815006071 dimerization interface [polypeptide binding]; other site 568815006072 ATP binding site [chemical binding]; other site 568815006073 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 568815006074 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 568815006075 C-terminal domain interface [polypeptide binding]; other site 568815006076 GSH binding site (G-site) [chemical binding]; other site 568815006077 dimer interface [polypeptide binding]; other site 568815006078 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 568815006079 N-terminal domain interface [polypeptide binding]; other site 568815006080 dimer interface [polypeptide binding]; other site 568815006081 substrate binding pocket (H-site) [chemical binding]; other site 568815006082 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 568815006083 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 568815006084 putative active site [active] 568815006085 catalytic triad [active] 568815006086 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 568815006087 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 568815006088 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 568815006089 ATP binding site [chemical binding]; other site 568815006090 active site 568815006091 substrate binding site [chemical binding]; other site 568815006092 Uncharacterized conserved protein [Function unknown]; Region: COG5467 568815006093 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 568815006094 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 568815006095 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 568815006096 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 568815006097 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 568815006098 putative metal binding site [ion binding]; other site 568815006099 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 568815006100 active site 568815006101 adenylosuccinate lyase; Provisional; Region: PRK07492 568815006102 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 568815006103 tetramer interface [polypeptide binding]; other site 568815006104 active site 568815006105 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 568815006106 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 568815006107 substrate binding site [chemical binding]; other site 568815006108 hexamer interface [polypeptide binding]; other site 568815006109 metal binding site [ion binding]; metal-binding site 568815006110 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 568815006111 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 568815006112 putative acyl-acceptor binding pocket; other site 568815006113 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 568815006114 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266 568815006115 putative NAD(P) binding site [chemical binding]; other site 568815006116 structural Zn binding site [ion binding]; other site 568815006117 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501 568815006118 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 568815006119 dimer interface [polypeptide binding]; other site 568815006120 active site 568815006121 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519 568815006122 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 568815006123 active site 568815006124 acyl carrier protein; Provisional; Region: PRK06508 568815006125 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 568815006126 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 568815006127 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 568815006128 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 568815006129 active site 568815006130 catalytic residues [active] 568815006131 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 568815006132 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 568815006133 substrate binding site [chemical binding]; other site 568815006134 ATP binding site [chemical binding]; other site 568815006135 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 568815006136 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 568815006137 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 568815006138 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 568815006139 active site 568815006140 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 568815006141 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568815006142 active site 568815006143 motif I; other site 568815006144 motif II; other site 568815006145 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 568815006146 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568815006147 substrate binding pocket [chemical binding]; other site 568815006148 membrane-bound complex binding site; other site 568815006149 hinge residues; other site 568815006150 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 568815006151 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 568815006152 FMN binding site [chemical binding]; other site 568815006153 active site 568815006154 catalytic residues [active] 568815006155 substrate binding site [chemical binding]; other site 568815006156 Predicted aspartyl protease [General function prediction only]; Region: COG3577 568815006157 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 568815006158 catalytic motif [active] 568815006159 Catalytic residue [active] 568815006160 Predicted Fe-S protein [General function prediction only]; Region: COG3313 568815006161 cobalamin synthase; Reviewed; Region: cobS; PRK00235 568815006162 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 568815006163 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 568815006164 putative dimer interface [polypeptide binding]; other site 568815006165 active site pocket [active] 568815006166 putative cataytic base [active] 568815006167 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 568815006168 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568815006169 putative DNA binding site [nucleotide binding]; other site 568815006170 putative Zn2+ binding site [ion binding]; other site 568815006171 AsnC family; Region: AsnC_trans_reg; pfam01037 568815006172 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 568815006173 putative uracil binding site [chemical binding]; other site 568815006174 putative active site [active] 568815006175 Staphylococcal nuclease homologues; Region: SNc; smart00318 568815006176 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 568815006177 Catalytic site; other site 568815006178 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 568815006179 Sel1-like repeats; Region: SEL1; smart00671 568815006180 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 568815006181 putative catalytic site [active] 568815006182 putative phosphate binding site [ion binding]; other site 568815006183 active site 568815006184 metal binding site A [ion binding]; metal-binding site 568815006185 DNA binding site [nucleotide binding] 568815006186 putative AP binding site [nucleotide binding]; other site 568815006187 putative metal binding site B [ion binding]; other site 568815006188 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 568815006189 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 568815006190 putative metal binding site [ion binding]; other site 568815006191 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 568815006192 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 568815006193 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 568815006194 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 568815006195 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 568815006196 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 568815006197 active site 568815006198 HIGH motif; other site 568815006199 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 568815006200 KMSK motif region; other site 568815006201 tRNA binding surface [nucleotide binding]; other site 568815006202 DALR anticodon binding domain; Region: DALR_1; smart00836 568815006203 anticodon binding site; other site 568815006204 Sporulation related domain; Region: SPOR; pfam05036 568815006205 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 568815006206 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 568815006207 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 568815006208 sec-independent translocase; Provisional; Region: PRK00708 568815006209 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 568815006210 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 568815006211 seryl-tRNA synthetase; Provisional; Region: PRK05431 568815006212 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 568815006213 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 568815006214 dimer interface [polypeptide binding]; other site 568815006215 active site 568815006216 motif 1; other site 568815006217 motif 2; other site 568815006218 motif 3; other site 568815006219 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 568815006220 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 568815006221 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568815006222 S-adenosylmethionine binding site [chemical binding]; other site 568815006223 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 568815006224 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 568815006225 Peptidase family M23; Region: Peptidase_M23; pfam01551 568815006226 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 568815006227 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568815006228 Walker A motif; other site 568815006229 ATP binding site [chemical binding]; other site 568815006230 Walker B motif; other site 568815006231 Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862 568815006232 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13023 568815006233 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 568815006234 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 568815006235 Protein export membrane protein; Region: SecD_SecF; pfam02355 568815006236 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 568815006237 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 568815006238 substrate binding pocket [chemical binding]; other site 568815006239 substrate-Mg2+ binding site; other site 568815006240 aspartate-rich region 1; other site 568815006241 aspartate-rich region 2; other site 568815006242 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 568815006243 Glucose inhibited division protein A; Region: GIDA; pfam01134 568815006244 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 568815006245 Predicted membrane protein [Function unknown]; Region: COG4872 568815006246 Uncharacterized membrane-anchored protein [Function unknown]; Region: COG4929 568815006247 trigger factor; Provisional; Region: tig; PRK01490 568815006248 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 568815006249 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 568815006250 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 568815006251 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 568815006252 GatB domain; Region: GatB_Yqey; smart00845 568815006253 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 568815006254 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 568815006255 NADH dehydrogenase; Validated; Region: PRK08183 568815006256 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765 568815006257 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 568815006258 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 568815006259 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 568815006260 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 568815006261 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 568815006262 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 568815006263 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 568815006264 carboxyltransferase (CT) interaction site; other site 568815006265 biotinylation site [posttranslational modification]; other site 568815006266 Dehydroquinase class II; Region: DHquinase_II; pfam01220 568815006267 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 568815006268 trimer interface [polypeptide binding]; other site 568815006269 active site 568815006270 dimer interface [polypeptide binding]; other site 568815006271 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 568815006272 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 568815006273 catalytic residues [active] 568815006274 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 568815006275 Peptidase family M48; Region: Peptidase_M48; cl12018 568815006276 aspartate aminotransferase; Provisional; Region: PRK05764 568815006277 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568815006278 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568815006279 homodimer interface [polypeptide binding]; other site 568815006280 catalytic residue [active] 568815006281 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 568815006282 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 568815006283 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 568815006284 AMIN domain; Region: AMIN; pfam11741 568815006285 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 568815006286 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 568815006287 active site 568815006288 metal binding site [ion binding]; metal-binding site 568815006289 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 568815006290 Transglycosylase; Region: Transgly; pfam00912 568815006291 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 568815006292 peptide chain release factor 2; Provisional; Region: PRK07342 568815006293 This domain is found in peptide chain release factors; Region: PCRF; smart00937 568815006294 RF-1 domain; Region: RF-1; pfam00472 568815006295 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 568815006296 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 568815006297 dinuclear metal binding motif [ion binding]; other site 568815006298 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 568815006299 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 568815006300 catalytic triad [active] 568815006301 AsmA family; Region: AsmA; pfam05170 568815006302 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 568815006303 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 568815006304 active site 568815006305 HIGH motif; other site 568815006306 dimer interface [polypeptide binding]; other site 568815006307 KMSKS motif; other site 568815006308 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568815006309 RNA binding surface [nucleotide binding]; other site 568815006310 Predicted molecular chaperone distantly related to HSP70-fold metalloproteases [Posttranslational modification, protein turnover, chaperones]; Region: COG2377 568815006311 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 568815006312 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 568815006313 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 568815006314 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 568815006315 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568815006316 catalytic residue [active] 568815006317 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 568815006318 putative ABC transporter; Region: ycf24; CHL00085 568815006319 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 568815006320 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 568815006321 Walker A/P-loop; other site 568815006322 ATP binding site [chemical binding]; other site 568815006323 Q-loop/lid; other site 568815006324 ABC transporter signature motif; other site 568815006325 Walker B; other site 568815006326 D-loop; other site 568815006327 H-loop/switch region; other site 568815006328 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 568815006329 FeS assembly protein SufD; Region: sufD; TIGR01981 568815006330 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 568815006331 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 568815006332 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568815006333 catalytic residue [active] 568815006334 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 568815006335 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 568815006336 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 568815006337 active site 568815006338 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 568815006339 ATP-NAD kinase; Region: NAD_kinase; pfam01513 568815006340 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 568815006341 helicase 45; Provisional; Region: PTZ00424 568815006342 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 568815006343 ATP binding site [chemical binding]; other site 568815006344 Mg++ binding site [ion binding]; other site 568815006345 motif III; other site 568815006346 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568815006347 nucleotide binding region [chemical binding]; other site 568815006348 ATP-binding site [chemical binding]; other site 568815006349 FeS assembly scaffold SufA; Region: sufA_proteo; TIGR01997 568815006350 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 568815006351 metal-binding site [ion binding] 568815006352 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 568815006353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568815006354 S-adenosylmethionine binding site [chemical binding]; other site 568815006355 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 568815006356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3827 568815006357 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 568815006358 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 568815006359 HIGH motif; other site 568815006360 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 568815006361 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 568815006362 active site 568815006363 KMSKS motif; other site 568815006364 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 568815006365 tRNA binding surface [nucleotide binding]; other site 568815006366 anticodon binding site; other site 568815006367 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 568815006368 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 568815006369 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 568815006370 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 568815006371 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 568815006372 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 568815006373 putative C-terminal domain interface [polypeptide binding]; other site 568815006374 putative GSH binding site (G-site) [chemical binding]; other site 568815006375 putative dimer interface [polypeptide binding]; other site 568815006376 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 568815006377 putative N-terminal domain interface [polypeptide binding]; other site 568815006378 putative dimer interface [polypeptide binding]; other site 568815006379 putative substrate binding pocket (H-site) [chemical binding]; other site 568815006380 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568815006381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815006382 dimer interface [polypeptide binding]; other site 568815006383 conserved gate region; other site 568815006384 putative PBP binding loops; other site 568815006385 ABC-ATPase subunit interface; other site 568815006386 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568815006387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815006388 dimer interface [polypeptide binding]; other site 568815006389 conserved gate region; other site 568815006390 putative PBP binding loops; other site 568815006391 ABC-ATPase subunit interface; other site 568815006392 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568815006393 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568815006394 substrate binding pocket [chemical binding]; other site 568815006395 membrane-bound complex binding site; other site 568815006396 hinge residues; other site 568815006397 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 568815006398 Walker A motif; other site 568815006399 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 568815006400 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 568815006401 GTP binding site; other site 568815006402 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 568815006403 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568815006404 FeS/SAM binding site; other site 568815006405 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 568815006406 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 568815006407 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 568815006408 hypothetical protein; Provisional; Region: PRK06753 568815006409 fumarate hydratase; Provisional; Region: PRK15389 568815006410 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 568815006411 Fumarase C-terminus; Region: Fumerase_C; pfam05683 568815006412 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 568815006413 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 568815006414 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 568815006415 Transglycosylase associated protein; Region: Transgly_assoc; pfam04226 568815006416 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 568815006417 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 568815006418 active site 568815006419 Int/Topo IB signature motif; other site 568815006420 catalytic residues [active] 568815006421 DNA binding site [nucleotide binding] 568815006422 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 568815006423 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 568815006424 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 568815006425 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929 568815006426 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 568815006427 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568815006428 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 568815006429 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 568815006430 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568815006431 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 568815006432 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 568815006433 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 568815006434 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 568815006435 ArsC family; Region: ArsC; pfam03960 568815006436 catalytic residues [active] 568815006437 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 568815006438 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 568815006439 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 568815006440 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 568815006441 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 568815006442 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 568815006443 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 568815006444 TMP-binding site; other site 568815006445 ATP-binding site [chemical binding]; other site 568815006446 DNA polymerase III subunit delta'; Validated; Region: PRK09112 568815006447 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 568815006448 DNA polymerase III subunit delta'; Validated; Region: PRK08485 568815006449 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 568815006450 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 568815006451 active site 568815006452 HIGH motif; other site 568815006453 KMSKS motif; other site 568815006454 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 568815006455 tRNA binding surface [nucleotide binding]; other site 568815006456 anticodon binding site; other site 568815006457 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 568815006458 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 568815006459 active site 568815006460 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 568815006461 putative hydrolase; Provisional; Region: PRK02113 568815006462 cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657 568815006463 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568815006464 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568815006465 Walker A/P-loop; other site 568815006466 ATP binding site [chemical binding]; other site 568815006467 Q-loop/lid; other site 568815006468 ABC transporter signature motif; other site 568815006469 Walker B; other site 568815006470 D-loop; other site 568815006471 H-loop/switch region; other site 568815006472 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 568815006473 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 568815006474 active site 568815006475 EamA-like transporter family; Region: EamA; pfam00892 568815006476 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 568815006477 EamA-like transporter family; Region: EamA; pfam00892 568815006478 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 568815006479 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 568815006480 motif I; other site 568815006481 active site 568815006482 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568815006483 motif II; other site 568815006484 Chaperone required for the assembly of the mitochondrial F1-ATPase [Posttranslational modification, protein turnover, chaperones]; Region: COG5387 568815006485 glutamine synthetase; Provisional; Region: glnA; PRK09469 568815006486 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 568815006487 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 568815006488 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 568815006489 Nitrogen regulatory protein P-II; Region: P-II; smart00938 568815006490 Uncharacterized conserved protein [Function unknown]; Region: COG0062 568815006491 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 568815006492 putative substrate binding site [chemical binding]; other site 568815006493 putative ATP binding site [chemical binding]; other site 568815006494 phosphoglycolate phosphatase; Provisional; Region: PRK13222 568815006495 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568815006496 motif II; other site 568815006497 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 568815006498 tetramer (dimer of dimers) interface [polypeptide binding]; other site 568815006499 active site 568815006500 dimer interface [polypeptide binding]; other site 568815006501 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3184 568815006502 glutathione reductase; Validated; Region: PRK06116 568815006503 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 568815006504 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568815006505 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 568815006506 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 568815006507 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 568815006508 NAD synthetase; Provisional; Region: PRK13981 568815006509 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 568815006510 multimer interface [polypeptide binding]; other site 568815006511 active site 568815006512 catalytic triad [active] 568815006513 protein interface 1 [polypeptide binding]; other site 568815006514 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 568815006515 homodimer interface [polypeptide binding]; other site 568815006516 NAD binding pocket [chemical binding]; other site 568815006517 ATP binding pocket [chemical binding]; other site 568815006518 Mg binding site [ion binding]; other site 568815006519 active-site loop [active] 568815006520 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 568815006521 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 568815006522 active site 568815006523 HIGH motif; other site 568815006524 nucleotide binding site [chemical binding]; other site 568815006525 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 568815006526 active site 568815006527 KMSKS motif; other site 568815006528 malic enzyme; Reviewed; Region: PRK12862 568815006529 Malic enzyme, N-terminal domain; Region: malic; pfam00390 568815006530 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 568815006531 putative NAD(P) binding site [chemical binding]; other site 568815006532 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 568815006533 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 568815006534 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 568815006535 active site 568815006536 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 568815006537 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 568815006538 Permease; Region: Permease; pfam02405 568815006539 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 568815006540 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 568815006541 Walker A/P-loop; other site 568815006542 ATP binding site [chemical binding]; other site 568815006543 Q-loop/lid; other site 568815006544 ABC transporter signature motif; other site 568815006545 Walker B; other site 568815006546 D-loop; other site 568815006547 H-loop/switch region; other site 568815006548 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 568815006549 mce related protein; Region: MCE; pfam02470 568815006550 ABC-type uncharacterized transport system, auxiliary component [General function prediction only]; Region: COG3218 568815006551 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 568815006552 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 568815006553 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 568815006554 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 568815006555 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 568815006556 catalytic loop [active] 568815006557 iron binding site [ion binding]; other site 568815006558 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 568815006559 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 568815006560 Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5661 568815006561 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 568815006562 dihydropteroate synthase; Region: DHPS; TIGR01496 568815006563 substrate binding pocket [chemical binding]; other site 568815006564 dimer interface [polypeptide binding]; other site 568815006565 inhibitor binding site; inhibition site 568815006566 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 568815006567 homooctamer interface [polypeptide binding]; other site 568815006568 active site 568815006569 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 568815006570 catalytic center binding site [active] 568815006571 ATP binding site [chemical binding]; other site 568815006572 Predicted membrane protein [Function unknown]; Region: COG3768 568815006573 Domain of unknown function (DUF697); Region: DUF697; cl12064 568815006574 Predicted ATPase [General function prediction only]; Region: COG3106 568815006575 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568815006576 catalytic core [active] 568815006577 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 568815006578 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 568815006579 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 568815006580 PAS domain; Region: PAS_9; pfam13426 568815006581 putative active site [active] 568815006582 heme pocket [chemical binding]; other site 568815006583 PAS domain; Region: PAS; smart00091 568815006584 PAS fold; Region: PAS_4; pfam08448 568815006585 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568815006586 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568815006587 dimer interface [polypeptide binding]; other site 568815006588 phosphorylation site [posttranslational modification] 568815006589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568815006590 ATP binding site [chemical binding]; other site 568815006591 Mg2+ binding site [ion binding]; other site 568815006592 G-X-G motif; other site 568815006593 Response regulator receiver domain; Region: Response_reg; pfam00072 568815006594 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568815006595 active site 568815006596 phosphorylation site [posttranslational modification] 568815006597 intermolecular recognition site; other site 568815006598 dimerization interface [polypeptide binding]; other site 568815006599 Predicted flavoproteins [General function prediction only]; Region: COG2081 568815006600 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 568815006601 Beta-lactamase; Region: Beta-lactamase; pfam00144 568815006602 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 568815006603 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 568815006604 Mechanosensitive ion channel; Region: MS_channel; pfam00924 568815006605 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 568815006606 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 568815006607 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 568815006608 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 568815006609 active site 568815006610 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 568815006611 TSCPD domain; Region: TSCPD; pfam12637 568815006612 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 568815006613 nudix motif; other site 568815006614 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568815006615 active site 568815006616 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 568815006617 Ligand Binding Site [chemical binding]; other site 568815006618 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 568815006619 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 568815006620 putative MPT binding site; other site 568815006621 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 568815006622 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 568815006623 threonine dehydratase; Validated; Region: PRK08639 568815006624 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 568815006625 tetramer interface [polypeptide binding]; other site 568815006626 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568815006627 catalytic residue [active] 568815006628 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 568815006629 putative Ile/Val binding site [chemical binding]; other site 568815006630 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 568815006631 DEAD-like helicases superfamily; Region: DEXDc; smart00487 568815006632 ATP binding site [chemical binding]; other site 568815006633 Mg++ binding site [ion binding]; other site 568815006634 motif III; other site 568815006635 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568815006636 nucleotide binding region [chemical binding]; other site 568815006637 ATP-binding site [chemical binding]; other site 568815006638 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 568815006639 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 568815006640 dimer interface [polypeptide binding]; other site 568815006641 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568815006642 catalytic residue [active] 568815006643 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 568815006644 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 568815006645 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 568815006646 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 568815006647 active site residue [active] 568815006648 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 568815006649 active site residue [active] 568815006650 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 568815006651 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568815006652 Coenzyme A binding pocket [chemical binding]; other site 568815006653 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 568815006654 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 568815006655 metal binding site [ion binding]; metal-binding site 568815006656 active site 568815006657 I-site; other site 568815006658 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 568815006659 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 568815006660 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 568815006661 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 568815006662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568815006663 putative substrate translocation pore; other site 568815006664 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 568815006665 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 568815006666 HlyD family secretion protein; Region: HlyD_3; pfam13437 568815006667 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 568815006668 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 568815006669 putative NAD(P) binding site [chemical binding]; other site 568815006670 putative substrate binding site [chemical binding]; other site 568815006671 catalytic Zn binding site [ion binding]; other site 568815006672 structural Zn binding site [ion binding]; other site 568815006673 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 568815006674 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 568815006675 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 568815006676 active site 568815006677 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 568815006678 Tetratricopeptide repeat; Region: TPR_1; pfam00515 568815006679 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568815006680 S-adenosylmethionine binding site [chemical binding]; other site 568815006681 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 568815006682 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 568815006683 UDP-glucose 4-epimerase; Region: PLN02240 568815006684 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 568815006685 NAD binding site [chemical binding]; other site 568815006686 homodimer interface [polypeptide binding]; other site 568815006687 active site 568815006688 substrate binding site [chemical binding]; other site 568815006689 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 568815006690 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 568815006691 homodimer interface [polypeptide binding]; other site 568815006692 metal binding site [ion binding]; metal-binding site 568815006693 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 568815006694 homodimer interface [polypeptide binding]; other site 568815006695 active site 568815006696 putative chemical substrate binding site [chemical binding]; other site 568815006697 metal binding site [ion binding]; metal-binding site 568815006698 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 568815006699 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 568815006700 putative FMN binding site [chemical binding]; other site 568815006701 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 568815006702 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 568815006703 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 568815006704 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 568815006705 active site 568815006706 dimer interface [polypeptide binding]; other site 568815006707 motif 1; other site 568815006708 motif 2; other site 568815006709 motif 3; other site 568815006710 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 568815006711 anticodon binding site; other site 568815006712 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 568815006713 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568815006714 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 568815006715 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 568815006716 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 568815006717 Sporulation related domain; Region: SPOR; pfam05036 568815006718 hypothetical protein; Validated; Region: PRK00041 568815006719 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 568815006720 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 568815006721 trimerization site [polypeptide binding]; other site 568815006722 active site 568815006723 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 568815006724 homodecamer interface [polypeptide binding]; other site 568815006725 GTP cyclohydrolase I; Provisional; Region: PLN03044 568815006726 active site 568815006727 putative catalytic site residues [active] 568815006728 zinc binding site [ion binding]; other site 568815006729 GTP-CH-I/GFRP interaction surface; other site 568815006730 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 568815006731 hypothetical protein; Provisional; Region: PRK10279 568815006732 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 568815006733 nucleophile elbow; other site 568815006734 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 568815006735 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 568815006736 active site 568815006737 DNA binding site [nucleotide binding] 568815006738 Int/Topo IB signature motif; other site 568815006739 BRO family, N-terminal domain; Region: Bro-N; cl10591 568815006740 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 568815006741 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 568815006742 catalytic residues [active] 568815006743 catalytic nucleophile [active] 568815006744 Presynaptic Site I dimer interface [polypeptide binding]; other site 568815006745 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 568815006746 Synaptic Flat tetramer interface [polypeptide binding]; other site 568815006747 Synaptic Site I dimer interface [polypeptide binding]; other site 568815006748 DNA binding site [nucleotide binding] 568815006749 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 568815006750 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 568815006751 Prophage antirepressor [Transcription]; Region: COG3617 568815006752 BRO family, N-terminal domain; Region: Bro-N; smart01040 568815006753 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568815006754 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568815006755 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 568815006756 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 568815006757 FAD binding site [chemical binding]; other site 568815006758 substrate binding pocket [chemical binding]; other site 568815006759 catalytic base [active] 568815006760 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 568815006761 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568815006762 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 568815006763 dimerization interface [polypeptide binding]; other site 568815006764 substrate binding pocket [chemical binding]; other site 568815006765 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 568815006766 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 568815006767 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 568815006768 multidrug efflux protein; Reviewed; Region: PRK09579 568815006769 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 568815006770 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 568815006771 HlyD family secretion protein; Region: HlyD_3; pfam13437 568815006772 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 568815006773 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 568815006774 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 568815006775 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 568815006776 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 568815006777 active site 568815006778 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 568815006779 active site 568815006780 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 568815006781 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 568815006782 active site 568815006783 (T/H)XGH motif; other site 568815006784 DNA gyrase subunit A; Validated; Region: PRK05560 568815006785 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 568815006786 CAP-like domain; other site 568815006787 active site 568815006788 primary dimer interface [polypeptide binding]; other site 568815006789 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568815006790 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568815006791 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568815006792 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568815006793 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568815006794 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 568815006795 Uncharacterized component of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3709 568815006796 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 568815006797 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568815006798 DNA-binding site [nucleotide binding]; DNA binding site 568815006799 UTRA domain; Region: UTRA; pfam07702 568815006800 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 568815006801 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 568815006802 dimer interface [polypeptide binding]; other site 568815006803 ssDNA binding site [nucleotide binding]; other site 568815006804 tetramer (dimer of dimers) interface [polypeptide binding]; other site 568815006805 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 568815006806 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 568815006807 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 568815006808 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 568815006809 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 568815006810 IHF dimer interface [polypeptide binding]; other site 568815006811 IHF - DNA interface [nucleotide binding]; other site 568815006812 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 568815006813 Found in ATP-dependent protease La (LON); Region: LON; smart00464 568815006814 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568815006815 Walker A motif; other site 568815006816 ATP binding site [chemical binding]; other site 568815006817 Walker B motif; other site 568815006818 arginine finger; other site 568815006819 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 568815006820 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 568815006821 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 568815006822 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568815006823 Walker A motif; other site 568815006824 ATP binding site [chemical binding]; other site 568815006825 Walker B motif; other site 568815006826 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 568815006827 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 568815006828 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 568815006829 oligomer interface [polypeptide binding]; other site 568815006830 active site residues [active] 568815006831 GTPases [General function prediction only]; Region: HflX; COG2262 568815006832 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 568815006833 HflX GTPase family; Region: HflX; cd01878 568815006834 G1 box; other site 568815006835 GTP/Mg2+ binding site [chemical binding]; other site 568815006836 Switch I region; other site 568815006837 G2 box; other site 568815006838 G3 box; other site 568815006839 Switch II region; other site 568815006840 G4 box; other site 568815006841 G5 box; other site 568815006842 bacterial Hfq-like; Region: Hfq; cd01716 568815006843 hexamer interface [polypeptide binding]; other site 568815006844 Sm1 motif; other site 568815006845 RNA binding site [nucleotide binding]; other site 568815006846 Sm2 motif; other site 568815006847 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 568815006848 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 568815006849 TrkA-N domain; Region: TrkA_N; pfam02254 568815006850 TrkA-C domain; Region: TrkA_C; pfam02080 568815006851 TrkA-N domain; Region: TrkA_N; pfam02254 568815006852 TrkA-C domain; Region: TrkA_C; pfam02080 568815006853 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 568815006854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568815006855 active site 568815006856 phosphorylation site [posttranslational modification] 568815006857 intermolecular recognition site; other site 568815006858 dimerization interface [polypeptide binding]; other site 568815006859 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568815006860 Walker A motif; other site 568815006861 ATP binding site [chemical binding]; other site 568815006862 Walker B motif; other site 568815006863 arginine finger; other site 568815006864 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 568815006865 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 568815006866 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 568815006867 dimerization interface [polypeptide binding]; other site 568815006868 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568815006869 dimer interface [polypeptide binding]; other site 568815006870 phosphorylation site [posttranslational modification] 568815006871 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568815006872 ATP binding site [chemical binding]; other site 568815006873 Mg2+ binding site [ion binding]; other site 568815006874 G-X-G motif; other site 568815006875 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 568815006876 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568815006877 active site 568815006878 phosphorylation site [posttranslational modification] 568815006879 intermolecular recognition site; other site 568815006880 dimerization interface [polypeptide binding]; other site 568815006881 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568815006882 Walker A motif; other site 568815006883 ATP binding site [chemical binding]; other site 568815006884 Walker B motif; other site 568815006885 arginine finger; other site 568815006886 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 568815006887 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 568815006888 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568815006889 dimer interface [polypeptide binding]; other site 568815006890 phosphorylation site [posttranslational modification] 568815006891 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568815006892 ATP binding site [chemical binding]; other site 568815006893 Mg2+ binding site [ion binding]; other site 568815006894 G-X-G motif; other site 568815006895 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 568815006896 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 568815006897 FMN binding site [chemical binding]; other site 568815006898 active site 568815006899 catalytic residues [active] 568815006900 substrate binding site [chemical binding]; other site 568815006901 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 568815006902 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 568815006903 substrate binding site; other site 568815006904 dimer interface; other site 568815006905 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 568815006906 homotrimer interaction site [polypeptide binding]; other site 568815006907 zinc binding site [ion binding]; other site 568815006908 CDP-binding sites; other site 568815006909 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 568815006910 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 568815006911 classical (c) SDRs; Region: SDR_c; cd05233 568815006912 NAD(P) binding site [chemical binding]; other site 568815006913 active site 568815006914 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 568815006915 putative coenzyme Q binding site [chemical binding]; other site 568815006916 lipoyl synthase; Provisional; Region: PRK05481 568815006917 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568815006918 FeS/SAM binding site; other site 568815006919 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 568815006920 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 568815006921 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568815006922 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 568815006923 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 568815006924 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 568815006925 E3 interaction surface; other site 568815006926 lipoyl attachment site [posttranslational modification]; other site 568815006927 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 568815006928 alpha subunit interface [polypeptide binding]; other site 568815006929 TPP binding site [chemical binding]; other site 568815006930 heterodimer interface [polypeptide binding]; other site 568815006931 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 568815006932 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 568815006933 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 568815006934 tetramer interface [polypeptide binding]; other site 568815006935 TPP-binding site [chemical binding]; other site 568815006936 heterodimer interface [polypeptide binding]; other site 568815006937 phosphorylation loop region [posttranslational modification] 568815006938 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 568815006939 Septum formation initiator; Region: DivIC; pfam04977 568815006940 Methyltransferase domain; Region: Methyltransf_23; pfam13489 568815006941 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568815006942 S-adenosylmethionine binding site [chemical binding]; other site 568815006943 enolase; Provisional; Region: eno; PRK00077 568815006944 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 568815006945 dimer interface [polypeptide binding]; other site 568815006946 metal binding site [ion binding]; metal-binding site 568815006947 substrate binding pocket [chemical binding]; other site 568815006948 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 568815006949 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 568815006950 CTP synthetase; Validated; Region: pyrG; PRK05380 568815006951 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 568815006952 Catalytic site [active] 568815006953 active site 568815006954 UTP binding site [chemical binding]; other site 568815006955 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 568815006956 active site 568815006957 putative oxyanion hole; other site 568815006958 catalytic triad [active] 568815006959 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 568815006960 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 568815006961 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 568815006962 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 568815006963 triosephosphate isomerase; Provisional; Region: PRK14565 568815006964 substrate binding site [chemical binding]; other site 568815006965 dimer interface [polypeptide binding]; other site 568815006966 catalytic triad [active] 568815006967 SurA N-terminal domain; Region: SurA_N_3; cl07813 568815006968 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 568815006969 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 568815006970 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 568815006971 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 568815006972 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 568815006973 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 568815006974 active site 568815006975 ribulose/triose binding site [chemical binding]; other site 568815006976 phosphate binding site [ion binding]; other site 568815006977 substrate (anthranilate) binding pocket [chemical binding]; other site 568815006978 product (indole) binding pocket [chemical binding]; other site 568815006979 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 568815006980 trimer interface [polypeptide binding]; other site 568815006981 dimer interface [polypeptide binding]; other site 568815006982 putative active site [active] 568815006983 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 568815006984 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 568815006985 dimer interface [polypeptide binding]; other site 568815006986 putative functional site; other site 568815006987 putative MPT binding site; other site 568815006988 LexA repressor; Validated; Region: PRK00215 568815006989 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 568815006990 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 568815006991 Catalytic site [active] 568815006992 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 568815006993 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 568815006994 Competence protein; Region: Competence; pfam03772 568815006995 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 568815006996 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 568815006997 active site 568815006998 HIGH motif; other site 568815006999 nucleotide binding site [chemical binding]; other site 568815007000 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 568815007001 active site 568815007002 KMSKS motif; other site 568815007003 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 568815007004 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 568815007005 dimer interface [polypeptide binding]; other site 568815007006 active site 568815007007 citrylCoA binding site [chemical binding]; other site 568815007008 NADH binding [chemical binding]; other site 568815007009 cationic pore residues; other site 568815007010 oxalacetate/citrate binding site [chemical binding]; other site 568815007011 coenzyme A binding site [chemical binding]; other site 568815007012 catalytic triad [active] 568815007013 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 568815007014 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 568815007015 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3494 568815007016 Acyl-[acyl carrier protein]; Region: LpxA; COG1043 568815007017 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 568815007018 active site 568815007019 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 568815007020 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 568815007021 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 568815007022 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 568815007023 trimer interface [polypeptide binding]; other site 568815007024 active site 568815007025 UDP-GlcNAc binding site [chemical binding]; other site 568815007026 lipid binding site [chemical binding]; lipid-binding site 568815007027 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 568815007028 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 568815007029 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 568815007030 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 568815007031 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 568815007032 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 568815007033 Surface antigen; Region: Bac_surface_Ag; pfam01103 568815007034 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 568815007035 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 568815007036 active site 568815007037 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 568815007038 protein binding site [polypeptide binding]; other site 568815007039 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 568815007040 putative substrate binding region [chemical binding]; other site 568815007041 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 568815007042 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 568815007043 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834 568815007044 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 568815007045 catalytic residue [active] 568815007046 putative FPP diphosphate binding site; other site 568815007047 putative FPP binding hydrophobic cleft; other site 568815007048 dimer interface [polypeptide binding]; other site 568815007049 putative IPP diphosphate binding site; other site 568815007050 ribosome recycling factor; Reviewed; Region: frr; PRK00083 568815007051 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 568815007052 hinge region; other site 568815007053 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 568815007054 putative nucleotide binding site [chemical binding]; other site 568815007055 uridine monophosphate binding site [chemical binding]; other site 568815007056 homohexameric interface [polypeptide binding]; other site 568815007057 elongation factor Ts; Provisional; Region: tsf; PRK09377 568815007058 UBA/TS-N domain; Region: UBA; pfam00627 568815007059 Elongation factor TS; Region: EF_TS; pfam00889 568815007060 Elongation factor TS; Region: EF_TS; pfam00889 568815007061 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 568815007062 rRNA interaction site [nucleotide binding]; other site 568815007063 S8 interaction site; other site 568815007064 putative laminin-1 binding site; other site 568815007065 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 568815007066 SnoaL-like domain; Region: SnoaL_3; pfam13474 568815007067 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 568815007068 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 568815007069 homotrimer interaction site [polypeptide binding]; other site 568815007070 putative active site [active] 568815007071 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_3; cd08585 568815007072 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 568815007073 putative active site [active] 568815007074 catalytic site [active] 568815007075 putative metal binding site [ion binding]; other site 568815007076 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 568815007077 Protein of unknown function, DUF482; Region: DUF482; pfam04339 568815007078 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 568815007079 HIT family signature motif; other site 568815007080 catalytic residue [active] 568815007081 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 568815007082 Clp amino terminal domain; Region: Clp_N; pfam02861 568815007083 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568815007084 Walker A motif; other site 568815007085 ATP binding site [chemical binding]; other site 568815007086 Walker B motif; other site 568815007087 arginine finger; other site 568815007088 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568815007089 Walker A motif; other site 568815007090 ATP binding site [chemical binding]; other site 568815007091 Walker B motif; other site 568815007092 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 568815007093 Uncharacterized conserved protein [Function unknown]; Region: COG2127 568815007094 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 568815007095 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 568815007096 Sporulation related domain; Region: SPOR; pfam05036 568815007097 Uncharacterized conserved protein [Function unknown]; Region: COG5458 568815007098 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 568815007099 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 568815007100 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 568815007101 Uncharacterized conserved protein [Function unknown]; Region: COG1434 568815007102 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 568815007103 putative active site [active] 568815007104 Predicted membrane protein [Function unknown]; Region: COG3503 568815007105 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 568815007106 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 568815007107 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 568815007108 DNA binding residues [nucleotide binding] 568815007109 putative dimer interface [polypeptide binding]; other site 568815007110 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 568815007111 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 568815007112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3803 568815007113 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568815007114 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568815007115 non-specific DNA binding site [nucleotide binding]; other site 568815007116 salt bridge; other site 568815007117 sequence-specific DNA binding site [nucleotide binding]; other site 568815007118 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 568815007119 Domain of unknown function (DUF955); Region: DUF955; pfam06114 568815007120 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 568815007121 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 568815007122 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 568815007123 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 568815007124 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 568815007125 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 568815007126 carboxyltransferase (CT) interaction site; other site 568815007127 biotinylation site [posttranslational modification]; other site 568815007128 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 568815007129 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 568815007130 active site 568815007131 substrate binding site [chemical binding]; other site 568815007132 coenzyme B12 binding site [chemical binding]; other site 568815007133 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 568815007134 B12 binding site [chemical binding]; other site 568815007135 cobalt ligand [ion binding]; other site 568815007136 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 568815007137 DctM-like transporters; Region: DctM; pfam06808 568815007138 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 568815007139 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 568815007140 glutamate racemase; Provisional; Region: PRK00865 568815007141 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 568815007142 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 568815007143 intracellular protease, PfpI family; Region: PfpI; TIGR01382 568815007144 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 568815007145 conserved cys residue [active] 568815007146 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 568815007147 isocitrate dehydrogenase; Validated; Region: PRK08299 568815007148 alkaline phosphatase; Provisional; Region: PRK10518 568815007149 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 568815007150 dimer interface [polypeptide binding]; other site 568815007151 active site 568815007152 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 568815007153 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 568815007154 motif 1; other site 568815007155 active site 568815007156 motif 2; other site 568815007157 motif 3; other site 568815007158 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 568815007159 recombinase A; Provisional; Region: recA; PRK09354 568815007160 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 568815007161 hexamer interface [polypeptide binding]; other site 568815007162 Walker A motif; other site 568815007163 ATP binding site [chemical binding]; other site 568815007164 Walker B motif; other site 568815007165 putative outer membrane lipoprotein; Provisional; Region: PRK10510 568815007166 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 568815007167 ligand binding site [chemical binding]; other site 568815007168 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 568815007169 N-acetyl-D-glucosamine binding site [chemical binding]; other site 568815007170 catalytic residue [active] 568815007171 recombination factor protein RarA; Reviewed; Region: PRK13342 568815007172 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568815007173 Walker A motif; other site 568815007174 ATP binding site [chemical binding]; other site 568815007175 Walker B motif; other site 568815007176 arginine finger; other site 568815007177 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 568815007178 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 568815007179 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 568815007180 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 568815007181 protein binding site [polypeptide binding]; other site 568815007182 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 568815007183 protein binding site [polypeptide binding]; other site 568815007184 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 568815007185 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 568815007186 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 568815007187 alphaNTD homodimer interface [polypeptide binding]; other site 568815007188 alphaNTD - beta interaction site [polypeptide binding]; other site 568815007189 alphaNTD - beta' interaction site [polypeptide binding]; other site 568815007190 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 568815007191 30S ribosomal protein S11; Validated; Region: PRK05309 568815007192 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 568815007193 30S ribosomal protein S13; Region: bact_S13; TIGR03631 568815007194 adenylate kinase; Reviewed; Region: adk; PRK00279 568815007195 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 568815007196 AMP-binding site [chemical binding]; other site 568815007197 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 568815007198 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 568815007199 SecY translocase; Region: SecY; pfam00344 568815007200 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 568815007201 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 568815007202 23S rRNA binding site [nucleotide binding]; other site 568815007203 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 568815007204 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 568815007205 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 568815007206 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 568815007207 5S rRNA interface [nucleotide binding]; other site 568815007208 23S rRNA interface [nucleotide binding]; other site 568815007209 L5 interface [polypeptide binding]; other site 568815007210 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 568815007211 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 568815007212 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 568815007213 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 568815007214 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 568815007215 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 568815007216 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 568815007217 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 568815007218 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 568815007219 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 568815007220 RNA binding site [nucleotide binding]; other site 568815007221 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 568815007222 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 568815007223 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 568815007224 23S rRNA interface [nucleotide binding]; other site 568815007225 putative translocon interaction site; other site 568815007226 signal recognition particle (SRP54) interaction site; other site 568815007227 L23 interface [polypeptide binding]; other site 568815007228 trigger factor interaction site; other site 568815007229 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 568815007230 23S rRNA interface [nucleotide binding]; other site 568815007231 5S rRNA interface [nucleotide binding]; other site 568815007232 putative antibiotic binding site [chemical binding]; other site 568815007233 L25 interface [polypeptide binding]; other site 568815007234 L27 interface [polypeptide binding]; other site 568815007235 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 568815007236 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 568815007237 G-X-X-G motif; other site 568815007238 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 568815007239 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 568815007240 putative translocon binding site; other site 568815007241 protein-rRNA interface [nucleotide binding]; other site 568815007242 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 568815007243 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 568815007244 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 568815007245 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 568815007246 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 568815007247 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 568815007248 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 568815007249 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 568815007250 elongation factor Tu; Reviewed; Region: PRK00049 568815007251 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 568815007252 G1 box; other site 568815007253 GEF interaction site [polypeptide binding]; other site 568815007254 GTP/Mg2+ binding site [chemical binding]; other site 568815007255 Switch I region; other site 568815007256 G2 box; other site 568815007257 G3 box; other site 568815007258 Switch II region; other site 568815007259 G4 box; other site 568815007260 G5 box; other site 568815007261 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 568815007262 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 568815007263 Antibiotic Binding Site [chemical binding]; other site 568815007264 elongation factor G; Reviewed; Region: PRK00007 568815007265 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 568815007266 G1 box; other site 568815007267 putative GEF interaction site [polypeptide binding]; other site 568815007268 GTP/Mg2+ binding site [chemical binding]; other site 568815007269 Switch I region; other site 568815007270 G2 box; other site 568815007271 G3 box; other site 568815007272 Switch II region; other site 568815007273 G4 box; other site 568815007274 G5 box; other site 568815007275 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 568815007276 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 568815007277 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 568815007278 30S ribosomal protein S7; Validated; Region: PRK05302 568815007279 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 568815007280 S17 interaction site [polypeptide binding]; other site 568815007281 S8 interaction site; other site 568815007282 16S rRNA interaction site [nucleotide binding]; other site 568815007283 streptomycin interaction site [chemical binding]; other site 568815007284 23S rRNA interaction site [nucleotide binding]; other site 568815007285 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 568815007286 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 568815007287 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 568815007288 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 568815007289 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 568815007290 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 568815007291 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 568815007292 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 568815007293 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 568815007294 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 568815007295 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 568815007296 DNA binding site [nucleotide binding] 568815007297 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 568815007298 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 568815007299 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 568815007300 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 568815007301 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 568815007302 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 568815007303 RPB11 interaction site [polypeptide binding]; other site 568815007304 RPB12 interaction site [polypeptide binding]; other site 568815007305 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 568815007306 RPB1 interaction site [polypeptide binding]; other site 568815007307 RPB11 interaction site [polypeptide binding]; other site 568815007308 RPB10 interaction site [polypeptide binding]; other site 568815007309 RPB3 interaction site [polypeptide binding]; other site 568815007310 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 568815007311 L11 interface [polypeptide binding]; other site 568815007312 putative EF-Tu interaction site [polypeptide binding]; other site 568815007313 putative EF-G interaction site [polypeptide binding]; other site 568815007314 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 568815007315 23S rRNA interface [nucleotide binding]; other site 568815007316 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 568815007317 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 568815007318 mRNA/rRNA interface [nucleotide binding]; other site 568815007319 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 568815007320 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 568815007321 23S rRNA interface [nucleotide binding]; other site 568815007322 L7/L12 interface [polypeptide binding]; other site 568815007323 putative thiostrepton binding site; other site 568815007324 L25 interface [polypeptide binding]; other site 568815007325 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 568815007326 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 568815007327 putative homodimer interface [polypeptide binding]; other site 568815007328 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 568815007329 heterodimer interface [polypeptide binding]; other site 568815007330 homodimer interface [polypeptide binding]; other site 568815007331 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 568815007332 elongation factor Tu; Reviewed; Region: PRK00049 568815007333 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 568815007334 G1 box; other site 568815007335 GEF interaction site [polypeptide binding]; other site 568815007336 GTP/Mg2+ binding site [chemical binding]; other site 568815007337 Switch I region; other site 568815007338 G2 box; other site 568815007339 G3 box; other site 568815007340 Switch II region; other site 568815007341 G4 box; other site 568815007342 G5 box; other site 568815007343 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 568815007344 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 568815007345 Antibiotic Binding Site [chemical binding]; other site 568815007346 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 568815007347 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 568815007348 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 568815007349 FOG: CBS domain [General function prediction only]; Region: COG0517 568815007350 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 568815007351 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 568815007352 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 568815007353 PAS domain; Region: PAS_5; pfam07310 568815007354 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 568815007355 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 568815007356 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 568815007357 trimer interface [polypeptide binding]; other site 568815007358 putative metal binding site [ion binding]; other site 568815007359 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 568815007360 serine acetyltransferase; Provisional; Region: cysE; PRK11132 568815007361 Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971 568815007362 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 568815007363 trimer interface [polypeptide binding]; other site 568815007364 active site 568815007365 substrate binding site [chemical binding]; other site 568815007366 CoA binding site [chemical binding]; other site 568815007367 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 568815007368 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 568815007369 Uncharacterized conserved protein [Function unknown]; Region: COG1430 568815007370 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 568815007371 DNA-binding site [nucleotide binding]; DNA binding site 568815007372 RNA-binding motif; other site 568815007373 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 568815007374 DNA-binding site [nucleotide binding]; DNA binding site 568815007375 RNA-binding motif; other site 568815007376 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 568815007377 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 568815007378 dimer interface [polypeptide binding]; other site 568815007379 active site 568815007380 metal binding site [ion binding]; metal-binding site 568815007381 glutathione binding site [chemical binding]; other site 568815007382 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 568815007383 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 568815007384 DHH family; Region: DHH; pfam01368 568815007385 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 568815007386 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 568815007387 ATP-grasp domain; Region: ATP-grasp_4; cl17255 568815007388 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 568815007389 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 568815007390 putative active site [active] 568815007391 homoserine dehydrogenase; Provisional; Region: PRK06349 568815007392 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 568815007393 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 568815007394 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 568815007395 aminotransferase; Validated; Region: PRK09148 568815007396 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568815007397 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568815007398 homodimer interface [polypeptide binding]; other site 568815007399 catalytic residue [active] 568815007400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 568815007401 Peptidase M15; Region: Peptidase_M15_3; cl01194 568815007402 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3553 568815007403 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 568815007404 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 568815007405 active site 568815007406 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 568815007407 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 568815007408 MPN+ (JAMM) motif; other site 568815007409 Zinc-binding site [ion binding]; other site 568815007410 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 568815007411 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568815007412 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 568815007413 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 568815007414 active site 568815007415 SAM binding site [chemical binding]; other site 568815007416 putative homodimer interface [polypeptide binding]; other site 568815007417 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 568815007418 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568815007419 S-adenosylmethionine binding site [chemical binding]; other site 568815007420 precorrin-3B synthase; Region: CobG; TIGR02435 568815007421 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 568815007422 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 568815007423 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 568815007424 Precorrin-8X methylmutase; Region: CbiC; pfam02570 568815007425 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 568815007426 active site 568815007427 SAM binding site [chemical binding]; other site 568815007428 homodimer interface [polypeptide binding]; other site 568815007429 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 568815007430 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 568815007431 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 568815007432 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 568815007433 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 568815007434 active site 568815007435 SAM binding site [chemical binding]; other site 568815007436 homodimer interface [polypeptide binding]; other site 568815007437 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 568815007438 Flavin Reductases; Region: FlaRed; cl00801 568815007439 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 568815007440 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 568815007441 ligand binding site [chemical binding]; other site 568815007442 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 568815007443 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 568815007444 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 568815007445 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568815007446 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568815007447 homodimer interface [polypeptide binding]; other site 568815007448 catalytic residue [active] 568815007449 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 568815007450 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 568815007451 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 568815007452 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 568815007453 active site 568815007454 SAM binding site [chemical binding]; other site 568815007455 homodimer interface [polypeptide binding]; other site 568815007456 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 568815007457 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 568815007458 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 568815007459 active site 568815007460 SAM binding site [chemical binding]; other site 568815007461 homodimer interface [polypeptide binding]; other site 568815007462 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 568815007463 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 568815007464 tellurium resistance terB-like protein; Region: terB_like; cd07177 568815007465 metal binding site [ion binding]; metal-binding site 568815007466 hypothetical protein; Provisional; Region: PRK10621 568815007467 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 568815007468 Predicted membrane protein [Function unknown]; Region: COG2510 568815007469 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 568815007470 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 568815007471 homodimer interface [polypeptide binding]; other site 568815007472 Walker A motif; other site 568815007473 ATP binding site [chemical binding]; other site 568815007474 hydroxycobalamin binding site [chemical binding]; other site 568815007475 Walker B motif; other site 568815007476 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 568815007477 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 568815007478 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 568815007479 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 568815007480 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 568815007481 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 568815007482 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 568815007483 homotrimer interface [polypeptide binding]; other site 568815007484 Walker A motif; other site 568815007485 GTP binding site [chemical binding]; other site 568815007486 Walker B motif; other site 568815007487 Predicted integral membrane protein [Function unknown]; Region: COG5446 568815007488 cobalt transporter subunit CbtB (proposed); Region: CbtB; TIGR02459 568815007489 cobyric acid synthase; Provisional; Region: PRK00784 568815007490 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 568815007491 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 568815007492 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 568815007493 catalytic triad [active] 568815007494 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 568815007495 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 568815007496 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 568815007497 substrate binding pocket [chemical binding]; other site 568815007498 FAD binding site [chemical binding]; other site 568815007499 catalytic base [active] 568815007500 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 568815007501 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 568815007502 Predicted small secreted protein [Function unknown]; Region: COG5510 568815007503 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568815007504 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568815007505 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568815007506 dimerization interface [polypeptide binding]; other site 568815007507 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 568815007508 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 568815007509 conserved cys residue [active] 568815007510 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568815007511 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568815007512 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 568815007513 hydroxyglutarate oxidase; Provisional; Region: PRK11728 568815007514 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 568815007515 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 568815007516 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 568815007517 Mechanosensitive ion channel; Region: MS_channel; pfam00924 568815007518 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 568815007519 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 568815007520 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 568815007521 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 568815007522 Protein export membrane protein; Region: SecD_SecF; pfam02355 568815007523 putative cation:proton antiport protein; Provisional; Region: PRK10669 568815007524 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 568815007525 TrkA-N domain; Region: TrkA_N; pfam02254 568815007526 Predicted integral membrane protein [Function unknown]; Region: COG0392 568815007527 Serine hydrolase; Region: Ser_hydrolase; pfam06821 568815007528 sulfate transport protein; Provisional; Region: cysT; CHL00187 568815007529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815007530 dimer interface [polypeptide binding]; other site 568815007531 conserved gate region; other site 568815007532 putative PBP binding loops; other site 568815007533 ABC-ATPase subunit interface; other site 568815007534 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 568815007535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815007536 dimer interface [polypeptide binding]; other site 568815007537 conserved gate region; other site 568815007538 putative PBP binding loops; other site 568815007539 ABC-ATPase subunit interface; other site 568815007540 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CysP; COG4150 568815007541 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 568815007542 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 568815007543 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 568815007544 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 568815007545 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 568815007546 Transporter associated domain; Region: CorC_HlyC; smart01091 568815007547 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 568815007548 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 568815007549 potential protein location (hypothetical protein BMI_I1346 [Brucella microti CCM 4915]) that overlaps RNA (tRNA-K) 568815007550 EF-hand domain pair; Region: EF_hand_5; pfam13499 568815007551 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 568815007552 Ca2+ binding site [ion binding]; other site 568815007553 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 568815007554 Ca2+ binding site [ion binding]; other site 568815007555 Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154 568815007556 short chain dehydrogenase; Provisional; Region: PRK06198 568815007557 classical (c) SDRs; Region: SDR_c; cd05233 568815007558 NAD(P) binding site [chemical binding]; other site 568815007559 active site 568815007560 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 568815007561 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 568815007562 Walker A/P-loop; other site 568815007563 ATP binding site [chemical binding]; other site 568815007564 Q-loop/lid; other site 568815007565 ABC transporter signature motif; other site 568815007566 Walker B; other site 568815007567 D-loop; other site 568815007568 H-loop/switch region; other site 568815007569 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568815007570 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 568815007571 TM-ABC transporter signature motif; other site 568815007572 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 568815007573 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 568815007574 putative ligand binding site [chemical binding]; other site 568815007575 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 568815007576 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 568815007577 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 568815007578 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 568815007579 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 568815007580 Walker A/P-loop; other site 568815007581 ATP binding site [chemical binding]; other site 568815007582 Q-loop/lid; other site 568815007583 ABC transporter signature motif; other site 568815007584 Walker B; other site 568815007585 D-loop; other site 568815007586 H-loop/switch region; other site 568815007587 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 568815007588 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 568815007589 ABC-ATPase subunit interface; other site 568815007590 dimer interface [polypeptide binding]; other site 568815007591 putative PBP binding regions; other site 568815007592 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 568815007593 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 568815007594 intersubunit interface [polypeptide binding]; other site 568815007595 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 568815007596 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 568815007597 N-terminal plug; other site 568815007598 ligand-binding site [chemical binding]; other site 568815007599 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 568815007600 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 568815007601 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 568815007602 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568815007603 Walker A/P-loop; other site 568815007604 ATP binding site [chemical binding]; other site 568815007605 Q-loop/lid; other site 568815007606 ABC transporter signature motif; other site 568815007607 Walker B; other site 568815007608 D-loop; other site 568815007609 H-loop/switch region; other site 568815007610 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568815007611 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568815007612 Walker A/P-loop; other site 568815007613 ATP binding site [chemical binding]; other site 568815007614 Q-loop/lid; other site 568815007615 ABC transporter signature motif; other site 568815007616 Walker B; other site 568815007617 D-loop; other site 568815007618 H-loop/switch region; other site 568815007619 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 568815007620 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 568815007621 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 568815007622 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 568815007623 HlyD family secretion protein; Region: HlyD_3; pfam13437 568815007624 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 568815007625 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 568815007626 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 568815007627 alpha-gamma subunit interface [polypeptide binding]; other site 568815007628 beta-gamma subunit interface [polypeptide binding]; other site 568815007629 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 568815007630 alpha-beta subunit interface [polypeptide binding]; other site 568815007631 urease subunit alpha; Reviewed; Region: ureC; PRK13309 568815007632 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 568815007633 subunit interactions [polypeptide binding]; other site 568815007634 active site 568815007635 flap region; other site 568815007636 urease accessory protein UreE; Provisional; Region: ureE; PRK14711 568815007637 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 568815007638 dimer interface [polypeptide binding]; other site 568815007639 catalytic residues [active] 568815007640 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 568815007641 UreF; Region: UreF; pfam01730 568815007642 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 568815007643 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 568815007644 Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413 568815007645 ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266 568815007646 cobalt transport protein CbiM; Validated; Region: PRK06265 568815007647 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 568815007648 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 568815007649 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 568815007650 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 568815007651 Walker A/P-loop; other site 568815007652 ATP binding site [chemical binding]; other site 568815007653 Q-loop/lid; other site 568815007654 ABC transporter signature motif; other site 568815007655 Walker B; other site 568815007656 D-loop; other site 568815007657 H-loop/switch region; other site 568815007658 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 568815007659 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 568815007660 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 568815007661 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 568815007662 nudix motif; other site 568815007663 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 568815007664 putative catalytic site [active] 568815007665 putative metal binding site [ion binding]; other site 568815007666 putative phosphate binding site [ion binding]; other site 568815007667 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 568815007668 putative metal binding site [ion binding]; other site 568815007669 BA14K-like protein; Region: BA14K; pfam07886 568815007670 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 568815007671 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568815007672 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568815007673 homodimer interface [polypeptide binding]; other site 568815007674 catalytic residue [active] 568815007675 ketol-acid reductoisomerase; Provisional; Region: PRK05479 568815007676 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 568815007677 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 568815007678 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568815007679 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568815007680 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 568815007681 potassium uptake protein; Region: kup; TIGR00794 568815007682 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 568815007683 active site 568815007684 hydrophilic channel; other site 568815007685 dimerization interface [polypeptide binding]; other site 568815007686 catalytic residues [active] 568815007687 active site lid [active] 568815007688 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 568815007689 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 568815007690 AAA domain; Region: AAA_30; pfam13604 568815007691 Family description; Region: UvrD_C_2; pfam13538 568815007692 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 568815007693 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 568815007694 putative valine binding site [chemical binding]; other site 568815007695 dimer interface [polypeptide binding]; other site 568815007696 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 568815007697 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 568815007698 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 568815007699 PYR/PP interface [polypeptide binding]; other site 568815007700 dimer interface [polypeptide binding]; other site 568815007701 TPP binding site [chemical binding]; other site 568815007702 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 568815007703 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 568815007704 TPP-binding site [chemical binding]; other site 568815007705 dimer interface [polypeptide binding]; other site 568815007706 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 568815007707 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 568815007708 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 568815007709 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 568815007710 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568815007711 motif II; other site 568815007712 Predicted flavoproteins [General function prediction only]; Region: COG2081 568815007713 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 568815007714 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 568815007715 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 568815007716 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 568815007717 protein binding site [polypeptide binding]; other site 568815007718 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 568815007719 protein binding site [polypeptide binding]; other site 568815007720 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 568815007721 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 568815007722 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 568815007723 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 568815007724 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 568815007725 HflK protein; Region: hflK; TIGR01933 568815007726 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 568815007727 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 568815007728 folate binding site [chemical binding]; other site 568815007729 NADP+ binding site [chemical binding]; other site 568815007730 thymidylate synthase; Reviewed; Region: thyA; PRK01827 568815007731 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 568815007732 dimerization interface [polypeptide binding]; other site 568815007733 active site 568815007734 Protein of unknown function (DUF2853); Region: DUF2853; pfam11015 568815007735 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568815007736 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 568815007737 putative substrate translocation pore; other site 568815007738 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 568815007739 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568815007740 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 568815007741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814 568815007742 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 568815007743 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 568815007744 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 568815007745 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 568815007746 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 568815007747 FAD binding domain; Region: FAD_binding_4; pfam01565 568815007748 Uncharacterized conserved protein [Function unknown]; Region: COG4702 568815007749 serine/threonine protein kinase; Provisional; Region: PRK09188 568815007750 serine/threonine protein kinase; Provisional; Region: PRK12274 568815007751 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 568815007752 Part of AAA domain; Region: AAA_19; pfam13245 568815007753 Family description; Region: UvrD_C_2; pfam13538 568815007754 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 568815007755 CreA protein; Region: CreA; pfam05981 568815007756 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 568815007757 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 568815007758 trimer interface [polypeptide binding]; other site 568815007759 active site 568815007760 substrate binding site [chemical binding]; other site 568815007761 CoA binding site [chemical binding]; other site 568815007762 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 568815007763 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 568815007764 Cu(I) binding site [ion binding]; other site 568815007765 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 568815007766 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568815007767 S-adenosylmethionine binding site [chemical binding]; other site 568815007768 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 568815007769 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 568815007770 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 568815007771 active site 568815007772 Uncharacterized conserved protein [Function unknown]; Region: COG5587 568815007773 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 568815007774 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 568815007775 nucleotide binding pocket [chemical binding]; other site 568815007776 K-X-D-G motif; other site 568815007777 catalytic site [active] 568815007778 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 568815007779 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 568815007780 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 568815007781 Dimer interface [polypeptide binding]; other site 568815007782 BRCT sequence motif; other site 568815007783 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 568815007784 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 568815007785 Walker A/P-loop; other site 568815007786 ATP binding site [chemical binding]; other site 568815007787 Q-loop/lid; other site 568815007788 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 568815007789 ABC transporter signature motif; other site 568815007790 Walker B; other site 568815007791 D-loop; other site 568815007792 H-loop/switch region; other site 568815007793 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 568815007794 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 568815007795 binding surface 568815007796 TPR motif; other site 568815007797 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 568815007798 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 568815007799 cell division protein FtsZ; Validated; Region: PRK09330 568815007800 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 568815007801 nucleotide binding site [chemical binding]; other site 568815007802 SulA interaction site; other site 568815007803 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 568815007804 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 568815007805 Cell division protein FtsA; Region: FtsA; smart00842 568815007806 Cell division protein FtsA; Region: FtsA; pfam14450 568815007807 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 568815007808 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 568815007809 Cell division protein FtsQ; Region: FtsQ; pfam03799 568815007810 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 568815007811 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 568815007812 ATP-grasp domain; Region: ATP-grasp_4; cl17255 568815007813 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 568815007814 FAD binding domain; Region: FAD_binding_4; pfam01565 568815007815 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 568815007816 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 568815007817 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 568815007818 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568815007819 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 568815007820 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 568815007821 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 568815007822 active site 568815007823 homodimer interface [polypeptide binding]; other site 568815007824 cell division protein FtsW; Region: ftsW; TIGR02614 568815007825 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 568815007826 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 568815007827 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568815007828 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 568815007829 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 568815007830 Mg++ binding site [ion binding]; other site 568815007831 putative catalytic motif [active] 568815007832 putative substrate binding site [chemical binding]; other site 568815007833 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 568815007834 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 568815007835 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568815007836 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 568815007837 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 568815007838 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 568815007839 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568815007840 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 568815007841 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 568815007842 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 568815007843 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 568815007844 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 568815007845 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 568815007846 MraW methylase family; Region: Methyltransf_5; cl17771 568815007847 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 568815007848 manganese transport protein MntH; Reviewed; Region: PRK00701 568815007849 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 568815007850 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 568815007851 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 568815007852 N-acetyl-D-glucosamine binding site [chemical binding]; other site 568815007853 catalytic residue [active] 568815007854 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 568815007855 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 568815007856 amidase catalytic site [active] 568815007857 Zn binding residues [ion binding]; other site 568815007858 substrate binding site [chemical binding]; other site 568815007859 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 568815007860 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 568815007861 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 568815007862 putative metal binding site [ion binding]; other site 568815007863 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 568815007864 HSP70 interaction site [polypeptide binding]; other site 568815007865 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 568815007866 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 568815007867 active site 568815007868 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 568815007869 murein hydrolase B; Provisional; Region: PRK10760; cl17906 568815007870 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 568815007871 Predicted permeases [General function prediction only]; Region: COG0679 568815007872 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 568815007873 FAD binding site [chemical binding]; other site 568815007874 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568815007875 dimerization interface [polypeptide binding]; other site 568815007876 putative DNA binding site [nucleotide binding]; other site 568815007877 putative Zn2+ binding site [ion binding]; other site 568815007878 Methyltransferase domain; Region: Methyltransf_23; pfam13489 568815007879 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568815007880 S-adenosylmethionine binding site [chemical binding]; other site 568815007881 Uncharacterized conserved protein [Function unknown]; Region: COG5586 568815007882 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 568815007883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568815007884 putative substrate translocation pore; other site 568815007885 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 568815007886 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568815007887 S-adenosylmethionine binding site [chemical binding]; other site 568815007888 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 568815007889 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568815007890 Walker A/P-loop; other site 568815007891 ATP binding site [chemical binding]; other site 568815007892 Q-loop/lid; other site 568815007893 ABC transporter signature motif; other site 568815007894 Walker B; other site 568815007895 D-loop; other site 568815007896 H-loop/switch region; other site 568815007897 ABC transporter; Region: ABC_tran_2; pfam12848 568815007898 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568815007899 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 568815007900 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 568815007901 PGAP1-like protein; Region: PGAP1; pfam07819 568815007902 Protein of unknown function (DUF1498); Region: DUF1498; pfam07385 568815007903 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 568815007904 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 568815007905 [2Fe-2S] cluster binding site [ion binding]; other site 568815007906 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 568815007907 putative alpha subunit interface [polypeptide binding]; other site 568815007908 putative active site [active] 568815007909 putative substrate binding site [chemical binding]; other site 568815007910 Fe binding site [ion binding]; other site 568815007911 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 568815007912 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 568815007913 FAD binding pocket [chemical binding]; other site 568815007914 FAD binding motif [chemical binding]; other site 568815007915 phosphate binding motif [ion binding]; other site 568815007916 beta-alpha-beta structure motif; other site 568815007917 NAD binding pocket [chemical binding]; other site 568815007918 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 568815007919 catalytic loop [active] 568815007920 iron binding site [ion binding]; other site 568815007921 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 568815007922 PhnA protein; Region: PhnA; pfam03831 568815007923 Isochorismatase family; Region: Isochorismatase; pfam00857 568815007924 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 568815007925 catalytic triad [active] 568815007926 metal binding site [ion binding]; metal-binding site 568815007927 conserved cis-peptide bond; other site 568815007928 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899 568815007929 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 568815007930 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 568815007931 active site 568815007932 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 568815007933 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 568815007934 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 568815007935 active site 568815007936 catalytic residues [active] 568815007937 DNA binding site [nucleotide binding] 568815007938 Int/Topo IB signature motif; other site 568815007939 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 568815007940 Uncharacterized conserved protein [Function unknown]; Region: COG2968 568815007941 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 568815007942 hypothetical protein; Provisional; Region: PRK05170 568815007943 Uncharacterized conserved protein [Function unknown]; Region: COG5453 568815007944 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 568815007945 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 568815007946 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 568815007947 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 568815007948 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 568815007949 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 568815007950 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 568815007951 DNA binding residues [nucleotide binding] 568815007952 DNA primase; Validated; Region: dnaG; PRK05667 568815007953 CHC2 zinc finger; Region: zf-CHC2; pfam01807 568815007954 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 568815007955 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 568815007956 active site 568815007957 metal binding site [ion binding]; metal-binding site 568815007958 interdomain interaction site; other site 568815007959 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 568815007960 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 568815007961 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 568815007962 PhoU domain; Region: PhoU; pfam01895 568815007963 PhoU domain; Region: PhoU; pfam01895 568815007964 Uncharacterized conserved protein [Function unknown]; Region: COG1610 568815007965 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 568815007966 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 568815007967 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 568815007968 catalytic site [active] 568815007969 subunit interface [polypeptide binding]; other site 568815007970 Predicted metalloprotease [General function prediction only]; Region: COG2321 568815007971 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 568815007972 Predicted membrane protein [Function unknown]; Region: COG5395 568815007973 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 568815007974 LytTr DNA-binding domain; Region: LytTR; pfam04397 568815007975 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 568815007976 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 568815007977 ATP-grasp domain; Region: ATP-grasp_4; cl17255 568815007978 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 568815007979 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 568815007980 ATP-grasp domain; Region: ATP-grasp_4; cl17255 568815007981 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 568815007982 IMP binding site; other site 568815007983 dimer interface [polypeptide binding]; other site 568815007984 partial ornithine binding site; other site 568815007985 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 568815007986 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 568815007987 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 568815007988 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 568815007989 nudix motif; other site 568815007990 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 568815007991 DNA-binding site [nucleotide binding]; DNA binding site 568815007992 RNA-binding motif; other site 568815007993 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 568815007994 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 568815007995 putative C-terminal domain interface [polypeptide binding]; other site 568815007996 putative GSH binding site (G-site) [chemical binding]; other site 568815007997 putative dimer interface [polypeptide binding]; other site 568815007998 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 568815007999 N-terminal domain interface [polypeptide binding]; other site 568815008000 dimer interface [polypeptide binding]; other site 568815008001 substrate binding pocket (H-site) [chemical binding]; other site 568815008002 aspartate aminotransferase; Provisional; Region: PRK05764 568815008003 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568815008004 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568815008005 homodimer interface [polypeptide binding]; other site 568815008006 catalytic residue [active] 568815008007 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568815008008 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568815008009 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 568815008010 putative effector binding pocket; other site 568815008011 dimerization interface [polypeptide binding]; other site 568815008012 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 568815008013 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 568815008014 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 568815008015 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 568815008016 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 568815008017 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568815008018 putative DNA binding site [nucleotide binding]; other site 568815008019 putative Zn2+ binding site [ion binding]; other site 568815008020 AsnC family; Region: AsnC_trans_reg; pfam01037 568815008021 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 568815008022 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568815008023 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 568815008024 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 568815008025 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 568815008026 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 568815008027 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 568815008028 EamA-like transporter family; Region: EamA; pfam00892 568815008029 EamA-like transporter family; Region: EamA; pfam00892 568815008030 Protein of unknown function, DUF486; Region: DUF486; cl01236 568815008031 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 568815008032 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 568815008033 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 568815008034 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 568815008035 Bacterial SH3 domain; Region: SH3_3; pfam08239 568815008036 excinuclease ABC subunit B; Provisional; Region: PRK05298 568815008037 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568815008038 ATP binding site [chemical binding]; other site 568815008039 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568815008040 nucleotide binding region [chemical binding]; other site 568815008041 ATP-binding site [chemical binding]; other site 568815008042 Ultra-violet resistance protein B; Region: UvrB; pfam12344 568815008043 UvrB/uvrC motif; Region: UVR; pfam02151 568815008044 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 568815008045 N-acetyl-D-glucosamine binding site [chemical binding]; other site 568815008046 catalytic residue [active] 568815008047 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 568815008048 DNA-binding site [nucleotide binding]; DNA binding site 568815008049 RNA-binding motif; other site 568815008050 BA14K-like protein; Region: BA14K; pfam07886 568815008051 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 568815008052 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 568815008053 MarR family; Region: MarR_2; pfam12802 568815008054 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568815008055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568815008056 active site 568815008057 phosphorylation site [posttranslational modification] 568815008058 intermolecular recognition site; other site 568815008059 dimerization interface [polypeptide binding]; other site 568815008060 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568815008061 DNA binding site [nucleotide binding] 568815008062 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 568815008063 dimer interface [polypeptide binding]; other site 568815008064 phosphorylation site [posttranslational modification] 568815008065 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568815008066 ATP binding site [chemical binding]; other site 568815008067 Mg2+ binding site [ion binding]; other site 568815008068 G-X-G motif; other site 568815008069 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 568815008070 dimer interface [polypeptide binding]; other site 568815008071 putative tRNA-binding site [nucleotide binding]; other site 568815008072 Uncharacterized conserved protein [Function unknown]; Region: COG5465 568815008073 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 568815008074 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 568815008075 Uncharacterized conserved protein [Function unknown]; Region: COG1565 568815008076 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 568815008077 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 568815008078 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 568815008079 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 568815008080 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 568815008081 active site 568815008082 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 568815008083 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 568815008084 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568815008085 active site 568815008086 HerA helicase [Replication, recombination, and repair]; Region: COG0433 568815008087 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 568815008088 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 568815008089 5S rRNA interface [nucleotide binding]; other site 568815008090 CTC domain interface [polypeptide binding]; other site 568815008091 L16 interface [polypeptide binding]; other site 568815008092 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 568815008093 putative active site [active] 568815008094 catalytic residue [active] 568815008095 GTP-binding protein YchF; Reviewed; Region: PRK09601 568815008096 YchF GTPase; Region: YchF; cd01900 568815008097 G1 box; other site 568815008098 GTP/Mg2+ binding site [chemical binding]; other site 568815008099 Switch I region; other site 568815008100 G2 box; other site 568815008101 Switch II region; other site 568815008102 G3 box; other site 568815008103 G4 box; other site 568815008104 G5 box; other site 568815008105 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 568815008106 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 568815008107 putative active site [active] 568815008108 putative catalytic site [active] 568815008109 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 568815008110 putative active site [active] 568815008111 putative catalytic site [active] 568815008112 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568815008113 active site 568815008114 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 568815008115 cytochrome b; Provisional; Region: CYTB; MTH00191 568815008116 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 568815008117 Qi binding site; other site 568815008118 intrachain domain interface; other site 568815008119 interchain domain interface [polypeptide binding]; other site 568815008120 heme bH binding site [chemical binding]; other site 568815008121 heme bL binding site [chemical binding]; other site 568815008122 Qo binding site; other site 568815008123 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 568815008124 interchain domain interface [polypeptide binding]; other site 568815008125 intrachain domain interface; other site 568815008126 Qi binding site; other site 568815008127 Qo binding site; other site 568815008128 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 568815008129 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 568815008130 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 568815008131 [2Fe-2S] cluster binding site [ion binding]; other site 568815008132 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568815008133 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568815008134 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568815008135 Walker A/P-loop; other site 568815008136 ATP binding site [chemical binding]; other site 568815008137 Q-loop/lid; other site 568815008138 ABC transporter signature motif; other site 568815008139 Walker B; other site 568815008140 D-loop; other site 568815008141 H-loop/switch region; other site 568815008142 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568815008143 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568815008144 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 568815008145 Walker A/P-loop; other site 568815008146 ATP binding site [chemical binding]; other site 568815008147 Q-loop/lid; other site 568815008148 ABC transporter signature motif; other site 568815008149 Walker B; other site 568815008150 D-loop; other site 568815008151 H-loop/switch region; other site 568815008152 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 568815008153 Purine nucleoside permease [Nucleotide transport and metabolism]; Region: NUP; COG5042 568815008154 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 568815008155 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 568815008156 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568815008157 Coenzyme A binding pocket [chemical binding]; other site 568815008158 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 568815008159 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 568815008160 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 568815008161 active site 568815008162 NTP binding site [chemical binding]; other site 568815008163 metal binding triad [ion binding]; metal-binding site 568815008164 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 568815008165 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 568815008166 putative active site [active] 568815008167 putative CoA binding site [chemical binding]; other site 568815008168 nudix motif; other site 568815008169 metal binding site [ion binding]; metal-binding site 568815008170 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 568815008171 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 568815008172 MoxR-like ATPases [General function prediction only]; Region: COG0714 568815008173 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 568815008174 ATP binding site [chemical binding]; other site 568815008175 Walker B motif; other site 568815008176 arginine finger; other site 568815008177 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 568815008178 Protein of unknown function DUF58; Region: DUF58; pfam01882 568815008179 N-terminal double-transmembrane domain; Region: two_anch; TIGR02226 568815008180 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 568815008181 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 568815008182 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 568815008183 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 568815008184 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568815008185 Coenzyme A binding pocket [chemical binding]; other site 568815008186 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 568815008187 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 568815008188 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 568815008189 putative dimer interface [polypeptide binding]; other site 568815008190 N-terminal domain interface [polypeptide binding]; other site 568815008191 putative substrate binding pocket (H-site) [chemical binding]; other site 568815008192 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 568815008193 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 568815008194 nudix motif; other site 568815008195 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 568815008196 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 568815008197 active site 568815008198 metal binding site [ion binding]; metal-binding site 568815008199 2-isopropylmalate synthase; Validated; Region: PRK03739 568815008200 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 568815008201 active site 568815008202 catalytic residues [active] 568815008203 metal binding site [ion binding]; metal-binding site 568815008204 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 568815008205 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 568815008206 Cation efflux family; Region: Cation_efflux; pfam01545 568815008207 anthranilate synthase; Provisional; Region: PRK13566 568815008208 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 568815008209 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 568815008210 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 568815008211 glutamine binding [chemical binding]; other site 568815008212 catalytic triad [active] 568815008213 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 568815008214 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568815008215 putative DNA binding site [nucleotide binding]; other site 568815008216 putative Zn2+ binding site [ion binding]; other site 568815008217 AsnC family; Region: AsnC_trans_reg; pfam01037 568815008218 Transcriptional regulators [Transcription]; Region: MarR; COG1846 568815008219 MarR family; Region: MarR_2; pfam12802 568815008220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568815008221 putative substrate translocation pore; other site 568815008222 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568815008223 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 568815008224 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5345 568815008225 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 568815008226 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 568815008227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815008228 dimer interface [polypeptide binding]; other site 568815008229 conserved gate region; other site 568815008230 putative PBP binding loops; other site 568815008231 ABC-ATPase subunit interface; other site 568815008232 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 568815008233 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568815008234 Walker A/P-loop; other site 568815008235 ATP binding site [chemical binding]; other site 568815008236 Q-loop/lid; other site 568815008237 ABC transporter signature motif; other site 568815008238 Walker B; other site 568815008239 D-loop; other site 568815008240 H-loop/switch region; other site 568815008241 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568815008242 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 568815008243 Walker A/P-loop; other site 568815008244 ATP binding site [chemical binding]; other site 568815008245 Q-loop/lid; other site 568815008246 ABC transporter signature motif; other site 568815008247 Walker B; other site 568815008248 D-loop; other site 568815008249 H-loop/switch region; other site 568815008250 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 568815008251 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 568815008252 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568815008253 Walker A/P-loop; other site 568815008254 ATP binding site [chemical binding]; other site 568815008255 Q-loop/lid; other site 568815008256 ABC transporter signature motif; other site 568815008257 Walker B; other site 568815008258 D-loop; other site 568815008259 H-loop/switch region; other site 568815008260 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 568815008261 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 568815008262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815008263 dimer interface [polypeptide binding]; other site 568815008264 conserved gate region; other site 568815008265 putative PBP binding loops; other site 568815008266 ABC-ATPase subunit interface; other site 568815008267 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 568815008268 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 568815008269 peptide binding site [polypeptide binding]; other site 568815008270 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 568815008271 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568815008272 dimerization interface [polypeptide binding]; other site 568815008273 putative DNA binding site [nucleotide binding]; other site 568815008274 putative Zn2+ binding site [ion binding]; other site 568815008275 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 568815008276 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 568815008277 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 568815008278 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 568815008279 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 568815008280 Ligand Binding Site [chemical binding]; other site 568815008281 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 568815008282 Predicted acetyltransferase [General function prediction only]; Region: COG2388 568815008283 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 568815008284 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5400 568815008285 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385 568815008286 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568815008287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568815008288 active site 568815008289 phosphorylation site [posttranslational modification] 568815008290 intermolecular recognition site; other site 568815008291 dimerization interface [polypeptide binding]; other site 568815008292 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568815008293 DNA binding site [nucleotide binding] 568815008294 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 568815008295 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 568815008296 inhibitor-cofactor binding pocket; inhibition site 568815008297 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568815008298 catalytic residue [active] 568815008299 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 568815008300 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 568815008301 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 568815008302 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 568815008303 PAS domain; Region: PAS_8; pfam13188 568815008304 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 568815008305 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 568815008306 putative active site [active] 568815008307 heme pocket [chemical binding]; other site 568815008308 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568815008309 dimer interface [polypeptide binding]; other site 568815008310 phosphorylation site [posttranslational modification] 568815008311 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568815008312 ATP binding site [chemical binding]; other site 568815008313 Mg2+ binding site [ion binding]; other site 568815008314 G-X-G motif; other site 568815008315 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 568815008316 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 568815008317 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 568815008318 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815008319 dimer interface [polypeptide binding]; other site 568815008320 conserved gate region; other site 568815008321 putative PBP binding loops; other site 568815008322 ABC-ATPase subunit interface; other site 568815008323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815008324 dimer interface [polypeptide binding]; other site 568815008325 conserved gate region; other site 568815008326 putative PBP binding loops; other site 568815008327 ABC-ATPase subunit interface; other site 568815008328 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 568815008329 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 568815008330 Walker A/P-loop; other site 568815008331 ATP binding site [chemical binding]; other site 568815008332 Q-loop/lid; other site 568815008333 ABC transporter signature motif; other site 568815008334 Walker B; other site 568815008335 D-loop; other site 568815008336 H-loop/switch region; other site 568815008337 TOBE domain; Region: TOBE_2; pfam08402 568815008338 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 568815008339 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 568815008340 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568815008341 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568815008342 non-specific DNA binding site [nucleotide binding]; other site 568815008343 salt bridge; other site 568815008344 sequence-specific DNA binding site [nucleotide binding]; other site 568815008345 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 568815008346 Domain of unknown function (DUF955); Region: DUF955; pfam06114 568815008347 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 568815008348 isocitrate lyase; Provisional; Region: PRK15063 568815008349 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 568815008350 tetramer interface [polypeptide binding]; other site 568815008351 active site 568815008352 Mg2+/Mn2+ binding site [ion binding]; other site 568815008353 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 568815008354 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 568815008355 NAD binding site [chemical binding]; other site 568815008356 substrate binding site [chemical binding]; other site 568815008357 homotetramer interface [polypeptide binding]; other site 568815008358 homodimer interface [polypeptide binding]; other site 568815008359 active site 568815008360 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 568815008361 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 568815008362 NAD binding site [chemical binding]; other site 568815008363 substrate binding site [chemical binding]; other site 568815008364 homotetramer interface [polypeptide binding]; other site 568815008365 homodimer interface [polypeptide binding]; other site 568815008366 active site 568815008367 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 568815008368 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 568815008369 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 568815008370 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 568815008371 active site 568815008372 nucleophile elbow; other site 568815008373 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 568815008374 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 568815008375 DAK2 domain; Region: Dak2; cl03685 568815008376 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 568815008377 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 568815008378 DNA binding residues [nucleotide binding] 568815008379 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 568815008380 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 568815008381 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 568815008382 DAK2 domain; Region: Dak2; pfam02734 568815008383 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 568815008384 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 568815008385 short chain dehydrogenase; Provisional; Region: PRK06841 568815008386 classical (c) SDRs; Region: SDR_c; cd05233 568815008387 NAD(P) binding site [chemical binding]; other site 568815008388 active site 568815008389 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 568815008390 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 568815008391 putative ligand binding site [chemical binding]; other site 568815008392 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568815008393 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 568815008394 TM-ABC transporter signature motif; other site 568815008395 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 568815008396 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 568815008397 Walker A/P-loop; other site 568815008398 ATP binding site [chemical binding]; other site 568815008399 Q-loop/lid; other site 568815008400 ABC transporter signature motif; other site 568815008401 Walker B; other site 568815008402 D-loop; other site 568815008403 H-loop/switch region; other site 568815008404 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 568815008405 Uncharacterized conserved protein [Function unknown]; Region: COG5591 568815008406 choline dehydrogenase; Validated; Region: PRK02106 568815008407 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 568815008408 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568815008409 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 568815008410 Bacterial transcriptional regulator; Region: IclR; pfam01614 568815008411 succinic semialdehyde dehydrogenase; Region: PLN02278 568815008412 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 568815008413 tetramerization interface [polypeptide binding]; other site 568815008414 NAD(P) binding site [chemical binding]; other site 568815008415 catalytic residues [active] 568815008416 Predicted membrane protein [Function unknown]; Region: COG1238 568815008417 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 568815008418 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 568815008419 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 568815008420 active site 568815008421 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 568815008422 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 568815008423 helix-hairpin-helix signature motif; other site 568815008424 substrate binding pocket [chemical binding]; other site 568815008425 active site 568815008426 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 568815008427 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 568815008428 active site 568815008429 HIGH motif; other site 568815008430 nucleotide binding site [chemical binding]; other site 568815008431 active site 568815008432 KMSKS motif; other site 568815008433 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 568815008434 active site 568815008435 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 568815008436 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568815008437 Coenzyme A binding pocket [chemical binding]; other site 568815008438 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 568815008439 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 568815008440 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 568815008441 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 568815008442 DNA binding residues [nucleotide binding] 568815008443 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 568815008444 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568815008445 RNA binding surface [nucleotide binding]; other site 568815008446 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 568815008447 active site 568815008448 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 568815008449 metal binding site 2 [ion binding]; metal-binding site 568815008450 putative DNA binding helix; other site 568815008451 metal binding site 1 [ion binding]; metal-binding site 568815008452 dimer interface [polypeptide binding]; other site 568815008453 structural Zn2+ binding site [ion binding]; other site 568815008454 PAS fold; Region: PAS_4; pfam08448 568815008455 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 568815008456 HWE histidine kinase; Region: HWE_HK; pfam07536 568815008457 two-component response regulator; Provisional; Region: PRK09191 568815008458 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568815008459 active site 568815008460 phosphorylation site [posttranslational modification] 568815008461 intermolecular recognition site; other site 568815008462 dimerization interface [polypeptide binding]; other site 568815008463 RNA polymerase sigma factor; Provisional; Region: PRK12516 568815008464 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 568815008465 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 568815008466 DNA binding residues [nucleotide binding] 568815008467 CHASE3 domain; Region: CHASE3; pfam05227 568815008468 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 568815008469 Histidine kinase; Region: HisKA_2; pfam07568 568815008470 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568815008471 ATP binding site [chemical binding]; other site 568815008472 Mg2+ binding site [ion binding]; other site 568815008473 G-X-G motif; other site 568815008474 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 568815008475 PRC-barrel domain; Region: PRC; pfam05239 568815008476 PRC-barrel domain; Region: PRC; pfam05239 568815008477 tonB-system energizer ExbB; Region: exbB; TIGR02797 568815008478 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 568815008479 TonB system transport protein ExbD, group 1; Region: ExbD_1; TIGR02803 568815008480 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 568815008481 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 568815008482 Predicted periplasmic protein [Function unknown]; Region: COG3698 568815008483 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 568815008484 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 568815008485 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 568815008486 Walker A/P-loop; other site 568815008487 ATP binding site [chemical binding]; other site 568815008488 Q-loop/lid; other site 568815008489 ABC transporter signature motif; other site 568815008490 Walker B; other site 568815008491 D-loop; other site 568815008492 H-loop/switch region; other site 568815008493 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 568815008494 FtsX-like permease family; Region: FtsX; pfam02687 568815008495 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 568815008496 trimer interface [polypeptide binding]; other site 568815008497 active site 568815008498 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 568815008499 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568815008500 dimerization interface [polypeptide binding]; other site 568815008501 putative DNA binding site [nucleotide binding]; other site 568815008502 putative Zn2+ binding site [ion binding]; other site 568815008503 AsnC family; Region: AsnC_trans_reg; pfam01037 568815008504 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 568815008505 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 568815008506 putative active site [active] 568815008507 putative dimer interface [polypeptide binding]; other site 568815008508 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 568815008509 diiron binding motif [ion binding]; other site 568815008510 Uncharacterized conserved protein [Function unknown]; Region: COG1633 568815008511 CCC1-related protein family; Region: CCC1_like_1; cd02437 568815008512 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568815008513 metabolite-proton symporter; Region: 2A0106; TIGR00883 568815008514 putative substrate translocation pore; other site 568815008515 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 568815008516 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 568815008517 GDP-binding site [chemical binding]; other site 568815008518 ACT binding site; other site 568815008519 IMP binding site; other site 568815008520 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 568815008521 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568815008522 Coenzyme A binding pocket [chemical binding]; other site 568815008523 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 568815008524 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 568815008525 ligand binding site [chemical binding]; other site 568815008526 NAD binding site [chemical binding]; other site 568815008527 dimerization interface [polypeptide binding]; other site 568815008528 catalytic site [active] 568815008529 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 568815008530 putative L-serine binding site [chemical binding]; other site 568815008531 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 568815008532 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568815008533 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 568815008534 catalytic residue [active] 568815008535 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 568815008536 Sodium Bile acid symporter family; Region: SBF; pfam01758 568815008537 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 568815008538 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 568815008539 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 568815008540 active site 568815008541 substrate binding site [chemical binding]; other site 568815008542 metal binding site [ion binding]; metal-binding site 568815008543 FtsH Extracellular; Region: FtsH_ext; pfam06480 568815008544 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 568815008545 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568815008546 Walker A motif; other site 568815008547 ATP binding site [chemical binding]; other site 568815008548 Walker B motif; other site 568815008549 arginine finger; other site 568815008550 Peptidase family M41; Region: Peptidase_M41; pfam01434 568815008551 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 568815008552 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 568815008553 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 568815008554 Tetratricopeptide repeat; Region: TPR_6; pfam13174 568815008555 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 568815008556 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 568815008557 ligand binding site [chemical binding]; other site 568815008558 translocation protein TolB; Provisional; Region: tolB; PRK05137 568815008559 TolB amino-terminal domain; Region: TolB_N; pfam04052 568815008560 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 568815008561 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 568815008562 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 568815008563 TolR protein; Region: tolR; TIGR02801 568815008564 TolQ protein; Region: tolQ; TIGR02796 568815008565 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 568815008566 active site 568815008567 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 568815008568 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568815008569 Walker A motif; other site 568815008570 ATP binding site [chemical binding]; other site 568815008571 Walker B motif; other site 568815008572 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 568815008573 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 568815008574 RuvA N terminal domain; Region: RuvA_N; pfam01330 568815008575 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 568815008576 active site 568815008577 putative DNA-binding cleft [nucleotide binding]; other site 568815008578 dimer interface [polypeptide binding]; other site 568815008579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5317 568815008580 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 568815008581 active site 568815008582 thiamine phosphate binding site [chemical binding]; other site 568815008583 pyrophosphate binding site [ion binding]; other site 568815008584 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 568815008585 Sel1-like repeats; Region: SEL1; smart00671 568815008586 Sel1-like repeats; Region: SEL1; smart00671 568815008587 elongation factor P; Validated; Region: PRK00529 568815008588 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 568815008589 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 568815008590 RNA binding site [nucleotide binding]; other site 568815008591 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 568815008592 RNA binding site [nucleotide binding]; other site 568815008593 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 568815008594 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 568815008595 active site 568815008596 dimerization interface [polypeptide binding]; other site 568815008597 hypothetical protein; Validated; Region: PRK09039 568815008598 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 568815008599 ligand binding site [chemical binding]; other site 568815008600 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 568815008601 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568815008602 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568815008603 Walker A/P-loop; other site 568815008604 ATP binding site [chemical binding]; other site 568815008605 Q-loop/lid; other site 568815008606 ABC transporter signature motif; other site 568815008607 Walker B; other site 568815008608 D-loop; other site 568815008609 H-loop/switch region; other site 568815008610 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 568815008611 hypothetical protein; Validated; Region: PRK00110 568815008612 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568815008613 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568815008614 DNA-binding site [nucleotide binding]; DNA binding site 568815008615 FCD domain; Region: FCD; pfam07729 568815008616 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 568815008617 Uncharacterized conserved protein [Function unknown]; Region: COG3543 568815008618 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 568815008619 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 568815008620 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 568815008621 putative active site [active] 568815008622 metal binding site [ion binding]; metal-binding site 568815008623 homodimer binding site [polypeptide binding]; other site 568815008624 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 568815008625 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 568815008626 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 568815008627 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 568815008628 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 568815008629 TPP-binding site [chemical binding]; other site 568815008630 dimer interface [polypeptide binding]; other site 568815008631 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 568815008632 PYR/PP interface [polypeptide binding]; other site 568815008633 dimer interface [polypeptide binding]; other site 568815008634 TPP binding site [chemical binding]; other site 568815008635 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 568815008636 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 568815008637 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 568815008638 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 568815008639 Phosphoglycerate kinase; Region: PGK; pfam00162 568815008640 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 568815008641 substrate binding site [chemical binding]; other site 568815008642 hinge regions; other site 568815008643 ADP binding site [chemical binding]; other site 568815008644 catalytic site [active] 568815008645 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 568815008646 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 568815008647 acyl-activating enzyme (AAE) consensus motif; other site 568815008648 putative AMP binding site [chemical binding]; other site 568815008649 putative active site [active] 568815008650 putative CoA binding site [chemical binding]; other site 568815008651 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568815008652 Predicted transcriptional regulator [Transcription]; Region: COG2378 568815008653 HTH domain; Region: HTH_11; pfam08279 568815008654 WYL domain; Region: WYL; pfam13280 568815008655 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 568815008656 CoenzymeA binding site [chemical binding]; other site 568815008657 subunit interaction site [polypeptide binding]; other site 568815008658 PHB binding site; other site 568815008659 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 568815008660 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820 568815008661 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 568815008662 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 568815008663 NAD(P) binding site [chemical binding]; other site 568815008664 Uncharacterized small protein containing a coiled-coil domain [Function unknown]; Region: COG5509 568815008665 putative MFS family transporter protein; Provisional; Region: PRK03633 568815008666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568815008667 putative substrate translocation pore; other site 568815008668 Uncharacterized small protein [Function unknown]; Region: COG5570 568815008669 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481 568815008670 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 568815008671 phosphoribosylaminoimidazole carboxylase, PurK protein; Region: purK; TIGR01161 568815008672 ATP-grasp domain; Region: ATP-grasp; pfam02222 568815008673 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 568815008674 TPR repeat; Region: TPR_11; pfam13414 568815008675 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 568815008676 TPR motif; other site 568815008677 binding surface 568815008678 pyruvate kinase; Provisional; Region: PRK06247 568815008679 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 568815008680 domain interfaces; other site 568815008681 active site 568815008682 Predicted integral membrane protein [Function unknown]; Region: COG5480 568815008683 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 568815008684 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3750 568815008685 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 568815008686 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568815008687 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568815008688 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 568815008689 Thiamine pyrophosphokinase; Region: TPK; cd07995 568815008690 active site 568815008691 dimerization interface [polypeptide binding]; other site 568815008692 thiamine binding site [chemical binding]; other site 568815008693 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 568815008694 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 568815008695 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 568815008696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815008697 dimer interface [polypeptide binding]; other site 568815008698 conserved gate region; other site 568815008699 putative PBP binding loops; other site 568815008700 ABC-ATPase subunit interface; other site 568815008701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815008702 dimer interface [polypeptide binding]; other site 568815008703 conserved gate region; other site 568815008704 putative PBP binding loops; other site 568815008705 ABC-ATPase subunit interface; other site 568815008706 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 568815008707 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 568815008708 Walker A/P-loop; other site 568815008709 ATP binding site [chemical binding]; other site 568815008710 Q-loop/lid; other site 568815008711 ABC transporter signature motif; other site 568815008712 Walker B; other site 568815008713 D-loop; other site 568815008714 H-loop/switch region; other site 568815008715 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 568815008716 Peptidase family M48; Region: Peptidase_M48; pfam01435 568815008717 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 568815008718 MOSC domain; Region: MOSC; pfam03473 568815008719 3-alpha domain; Region: 3-alpha; pfam03475 568815008720 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 568815008721 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 568815008722 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 568815008723 DNA binding residues [nucleotide binding] 568815008724 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 568815008725 Ferredoxin [Energy production and conversion]; Region: COG1146 568815008726 4Fe-4S binding domain; Region: Fer4; pfam00037 568815008727 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 568815008728 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568815008729 RNA binding surface [nucleotide binding]; other site 568815008730 DEAD/DEAH box helicase; Region: DEAD; pfam00270 568815008731 ATP binding site [chemical binding]; other site 568815008732 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 568815008733 putative Mg++ binding site [ion binding]; other site 568815008734 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568815008735 nucleotide binding region [chemical binding]; other site 568815008736 ATP-binding site [chemical binding]; other site 568815008737 putative acyltransferase; Provisional; Region: PRK05790 568815008738 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 568815008739 dimer interface [polypeptide binding]; other site 568815008740 active site 568815008741 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 568815008742 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 568815008743 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 568815008744 Transglycosylase; Region: Transgly; pfam00912 568815008745 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 568815008746 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 568815008747 substrate binding pocket [chemical binding]; other site 568815008748 chain length determination region; other site 568815008749 substrate-Mg2+ binding site; other site 568815008750 catalytic residues [active] 568815008751 aspartate-rich region 1; other site 568815008752 active site lid residues [active] 568815008753 aspartate-rich region 2; other site 568815008754 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 568815008755 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 568815008756 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 568815008757 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 568815008758 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568815008759 NAD(P) binding site [chemical binding]; other site 568815008760 active site 568815008761 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568815008762 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568815008763 putative substrate translocation pore; other site 568815008764 pyruvate carboxylase; Reviewed; Region: PRK12999 568815008765 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 568815008766 ATP-grasp domain; Region: ATP-grasp_4; cl17255 568815008767 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 568815008768 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 568815008769 active site 568815008770 catalytic residues [active] 568815008771 metal binding site [ion binding]; metal-binding site 568815008772 homodimer binding site [polypeptide binding]; other site 568815008773 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 568815008774 carboxyltransferase (CT) interaction site; other site 568815008775 biotinylation site [posttranslational modification]; other site 568815008776 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 568815008777 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 568815008778 dimerization interface [polypeptide binding]; other site 568815008779 ligand binding site [chemical binding]; other site 568815008780 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 568815008781 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 568815008782 dimerization interface [polypeptide binding]; other site 568815008783 ligand binding site [chemical binding]; other site 568815008784 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 568815008785 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 568815008786 Walker A/P-loop; other site 568815008787 ATP binding site [chemical binding]; other site 568815008788 Q-loop/lid; other site 568815008789 ABC transporter signature motif; other site 568815008790 Walker B; other site 568815008791 D-loop; other site 568815008792 H-loop/switch region; other site 568815008793 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 568815008794 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 568815008795 Walker A/P-loop; other site 568815008796 ATP binding site [chemical binding]; other site 568815008797 Q-loop/lid; other site 568815008798 ABC transporter signature motif; other site 568815008799 Walker B; other site 568815008800 D-loop; other site 568815008801 H-loop/switch region; other site 568815008802 Uncharacterized conserved protein [Function unknown]; Region: COG3743 568815008803 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 568815008804 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 568815008805 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 568815008806 TM-ABC transporter signature motif; other site 568815008807 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568815008808 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 568815008809 TM-ABC transporter signature motif; other site 568815008810 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 568815008811 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 568815008812 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 568815008813 Transcriptional regulators [Transcription]; Region: FadR; COG2186 568815008814 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568815008815 DNA-binding site [nucleotide binding]; DNA binding site 568815008816 FCD domain; Region: FCD; pfam07729 568815008817 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 568815008818 MarR family; Region: MarR; pfam01047 568815008819 F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355 568815008820 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 568815008821 gamma subunit interface [polypeptide binding]; other site 568815008822 epsilon subunit interface [polypeptide binding]; other site 568815008823 LBP interface [polypeptide binding]; other site 568815008824 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 568815008825 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 568815008826 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 568815008827 alpha subunit interaction interface [polypeptide binding]; other site 568815008828 Walker A motif; other site 568815008829 ATP binding site [chemical binding]; other site 568815008830 Walker B motif; other site 568815008831 inhibitor binding site; inhibition site 568815008832 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 568815008833 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 568815008834 core domain interface [polypeptide binding]; other site 568815008835 delta subunit interface [polypeptide binding]; other site 568815008836 epsilon subunit interface [polypeptide binding]; other site 568815008837 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 568815008838 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 568815008839 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 568815008840 beta subunit interaction interface [polypeptide binding]; other site 568815008841 Walker A motif; other site 568815008842 ATP binding site [chemical binding]; other site 568815008843 Walker B motif; other site 568815008844 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 568815008845 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 568815008846 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 568815008847 primosome assembly protein PriA; Validated; Region: PRK05580 568815008848 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568815008849 ATP binding site [chemical binding]; other site 568815008850 putative Mg++ binding site [ion binding]; other site 568815008851 helicase superfamily c-terminal domain; Region: HELICc; smart00490 568815008852 nucleotide binding region [chemical binding]; other site 568815008853 ATP-binding site [chemical binding]; other site 568815008854 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 568815008855 active site 568815008856 intersubunit interactions; other site 568815008857 catalytic residue [active] 568815008858 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5468 568815008859 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 568815008860 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 568815008861 HIGH motif; other site 568815008862 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 568815008863 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 568815008864 active site 568815008865 KMSKS motif; other site 568815008866 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 568815008867 tRNA binding surface [nucleotide binding]; other site 568815008868 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 568815008869 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 568815008870 catalytic residue [active] 568815008871 Predicted membrane protein [Function unknown]; Region: COG1289 568815008872 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 568815008873 Usg protein, probable subunit of phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; Region: COG5425 568815008874 acetyl-CoA synthetase; Provisional; Region: PRK00174 568815008875 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 568815008876 active site 568815008877 CoA binding site [chemical binding]; other site 568815008878 acyl-activating enzyme (AAE) consensus motif; other site 568815008879 AMP binding site [chemical binding]; other site 568815008880 acetate binding site [chemical binding]; other site 568815008881 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 568815008882 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 568815008883 heat shock protein HtpX; Provisional; Region: PRK01345 568815008884 NusB family; Region: NusB; pfam01029 568815008885 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 568815008886 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568815008887 S-adenosylmethionine binding site [chemical binding]; other site 568815008888 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5360 568815008889 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 568815008890 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 568815008891 purine monophosphate binding site [chemical binding]; other site 568815008892 dimer interface [polypeptide binding]; other site 568815008893 putative catalytic residues [active] 568815008894 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 568815008895 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 568815008896 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 568815008897 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 568815008898 Predicted membrane protein [Function unknown]; Region: COG3762 568815008899 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 568815008900 Repair protein; Region: Repair_PSII; pfam04536 568815008901 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 568815008902 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 568815008903 chorismate mutase; Provisional; Region: PRK09239 568815008904 signal recognition particle protein; Provisional; Region: PRK10867 568815008905 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 568815008906 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 568815008907 P loop; other site 568815008908 GTP binding site [chemical binding]; other site 568815008909 Signal peptide binding domain; Region: SRP_SPB; pfam02978 568815008910 lytic murein transglycosylase; Region: MltB_2; TIGR02283 568815008911 murein hydrolase B; Provisional; Region: PRK10760; cl17906 568815008912 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 568815008913 active site clefts [active] 568815008914 zinc binding site [ion binding]; other site 568815008915 dimer interface [polypeptide binding]; other site 568815008916 pyridoxamine kinase; Validated; Region: PRK05756 568815008917 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 568815008918 dimer interface [polypeptide binding]; other site 568815008919 pyridoxal binding site [chemical binding]; other site 568815008920 ATP binding site [chemical binding]; other site 568815008921 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 568815008922 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 568815008923 tetrameric interface [polypeptide binding]; other site 568815008924 NAD binding site [chemical binding]; other site 568815008925 catalytic residues [active] 568815008926 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568815008927 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568815008928 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 568815008929 putative effector binding pocket; other site 568815008930 dimerization interface [polypeptide binding]; other site 568815008931 Predicted membrane protein [Function unknown]; Region: COG3619 568815008932 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 568815008933 putative active site [active] 568815008934 Ap4A binding site [chemical binding]; other site 568815008935 nudix motif; other site 568815008936 putative metal binding site [ion binding]; other site 568815008937 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 568815008938 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 568815008939 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 568815008940 protein binding site [polypeptide binding]; other site 568815008941 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 568815008942 Catalytic dyad [active] 568815008943 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 568815008944 Peptidase family M23; Region: Peptidase_M23; pfam01551 568815008945 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 568815008946 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 568815008947 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 568815008948 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 568815008949 active site 568815008950 (T/H)XGH motif; other site 568815008951 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 568815008952 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 568815008953 putative catalytic cysteine [active] 568815008954 gamma-glutamyl kinase; Provisional; Region: PRK05429 568815008955 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 568815008956 nucleotide binding site [chemical binding]; other site 568815008957 homotetrameric interface [polypeptide binding]; other site 568815008958 putative phosphate binding site [ion binding]; other site 568815008959 putative allosteric binding site; other site 568815008960 PUA domain; Region: PUA; pfam01472 568815008961 GTPase CgtA; Reviewed; Region: obgE; PRK12299 568815008962 GTP1/OBG; Region: GTP1_OBG; pfam01018 568815008963 Obg GTPase; Region: Obg; cd01898 568815008964 G1 box; other site 568815008965 GTP/Mg2+ binding site [chemical binding]; other site 568815008966 Switch I region; other site 568815008967 G2 box; other site 568815008968 G3 box; other site 568815008969 Switch II region; other site 568815008970 G4 box; other site 568815008971 G5 box; other site 568815008972 YadA-like C-terminal region; Region: YadA; pfam03895 568815008973 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 568815008974 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 568815008975 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 568815008976 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 568815008977 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 568815008978 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 568815008979 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 568815008980 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 568815008981 Integrase core domain; Region: rve; pfam00665 568815008982 Helix-turn-helix; Region: HTH_3; pfam01381 568815008983 Cupin domain; Region: Cupin_2; cl17218 568815008984 Methyltransferase domain; Region: Methyltransf_31; pfam13847 568815008985 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568815008986 S-adenosylmethionine binding site [chemical binding]; other site 568815008987 AzlC protein; Region: AzlC; pfam03591 568815008988 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 568815008989 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 568815008990 Integrase core domain; Region: rve; pfam00665 568815008991 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 568815008992 Peptidase family M23; Region: Peptidase_M23; pfam01551 568815008993 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 568815008994 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 568815008995 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 568815008996 Clp amino terminal domain; Region: Clp_N; pfam02861 568815008997 Clp amino terminal domain; Region: Clp_N; pfam02861 568815008998 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568815008999 Walker A motif; other site 568815009000 ATP binding site [chemical binding]; other site 568815009001 Walker B motif; other site 568815009002 arginine finger; other site 568815009003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568815009004 Walker A motif; other site 568815009005 ATP binding site [chemical binding]; other site 568815009006 Walker B motif; other site 568815009007 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 568815009008 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 568815009009 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 568815009010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568815009011 S-adenosylmethionine binding site [chemical binding]; other site 568815009012 peptide chain release factor 1; Validated; Region: prfA; PRK00591 568815009013 This domain is found in peptide chain release factors; Region: PCRF; smart00937 568815009014 RF-1 domain; Region: RF-1; pfam00472 568815009015 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 568815009016 GAF domain; Region: GAF; pfam01590 568815009017 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 568815009018 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 568815009019 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 568815009020 aspartate kinase; Reviewed; Region: PRK06635 568815009021 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 568815009022 putative nucleotide binding site [chemical binding]; other site 568815009023 putative catalytic residues [active] 568815009024 putative Mg ion binding site [ion binding]; other site 568815009025 putative aspartate binding site [chemical binding]; other site 568815009026 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 568815009027 putative allosteric regulatory site; other site 568815009028 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 568815009029 putative allosteric regulatory residue; other site 568815009030 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 568815009031 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568815009032 S-adenosylmethionine binding site [chemical binding]; other site 568815009033 EamA-like transporter family; Region: EamA; pfam00892 568815009034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5319 568815009035 Predicted amidohydrolase [General function prediction only]; Region: COG0388 568815009036 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 568815009037 putative active site [active] 568815009038 catalytic triad [active] 568815009039 dimer interface [polypeptide binding]; other site 568815009040 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 568815009041 GSH binding site [chemical binding]; other site 568815009042 catalytic residues [active] 568815009043 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 568815009044 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568815009045 active site 568815009046 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 568815009047 Methyltransferase domain; Region: Methyltransf_11; pfam08241 568815009048 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 568815009049 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 568815009050 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568815009051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568815009052 putative substrate translocation pore; other site 568815009053 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 568815009054 putative metal binding site [ion binding]; other site 568815009055 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 568815009056 HemY protein N-terminus; Region: HemY_N; pfam07219 568815009057 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 568815009058 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 568815009059 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 568815009060 active site 568815009061 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 568815009062 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 568815009063 domain interfaces; other site 568815009064 active site 568815009065 UGMP family protein; Validated; Region: PRK09604 568815009066 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 568815009067 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 568815009068 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 568815009069 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 568815009070 YCII-related domain; Region: YCII; cl00999 568815009071 Uncharacterized conserved protein [Function unknown]; Region: COG2947 568815009072 Predicted methyltransferase [General function prediction only]; Region: COG3897 568815009073 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568815009074 S-adenosylmethionine binding site [chemical binding]; other site 568815009075 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 568815009076 EamA-like transporter family; Region: EamA; pfam00892 568815009077 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 568815009078 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568815009079 DNA-binding site [nucleotide binding]; DNA binding site 568815009080 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568815009081 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568815009082 homodimer interface [polypeptide binding]; other site 568815009083 catalytic residue [active] 568815009084 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 568815009085 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 568815009086 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 568815009087 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 568815009088 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 568815009089 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 568815009090 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 568815009091 active site 568815009092 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 568815009093 catalytic triad [active] 568815009094 dimer interface [polypeptide binding]; other site 568815009095 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333 568815009096 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 568815009097 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 568815009098 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 568815009099 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 568815009100 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 568815009101 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 568815009102 L-aspartate oxidase; Provisional; Region: PRK06175 568815009103 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 568815009104 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 568815009105 putative SdhC subunit interface [polypeptide binding]; other site 568815009106 putative proximal heme binding site [chemical binding]; other site 568815009107 putative Iron-sulfur protein interface [polypeptide binding]; other site 568815009108 putative proximal quinone binding site; other site 568815009109 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 568815009110 Iron-sulfur protein interface; other site 568815009111 proximal quinone binding site [chemical binding]; other site 568815009112 SdhD (CybS) interface [polypeptide binding]; other site 568815009113 proximal heme binding site [chemical binding]; other site 568815009114 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568815009115 Coenzyme A binding pocket [chemical binding]; other site 568815009116 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 568815009117 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 568815009118 substrate binding site [chemical binding]; other site 568815009119 ligand binding site [chemical binding]; other site 568815009120 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 568815009121 Cytosine/uracil/thiamine/allantoin permeases [Nucleotide transport and metabolism / Coenzyme metabolism]; Region: FUI1; COG1953 568815009122 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 568815009123 Na binding site [ion binding]; other site 568815009124 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 568815009125 NIPSNAP; Region: NIPSNAP; pfam07978 568815009126 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568815009127 dimerization interface [polypeptide binding]; other site 568815009128 putative DNA binding site [nucleotide binding]; other site 568815009129 putative Zn2+ binding site [ion binding]; other site 568815009130 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 568815009131 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 568815009132 RimM N-terminal domain; Region: RimM; pfam01782 568815009133 PRC-barrel domain; Region: PRC; pfam05239 568815009134 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 568815009135 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 568815009136 active site 568815009137 DNA binding site [nucleotide binding] 568815009138 Int/Topo IB signature motif; other site 568815009139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 568815009140 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 568815009141 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 568815009142 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568815009143 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 568815009144 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 568815009145 Predicted membrane protein [Function unknown]; Region: COG3686 568815009146 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 568815009147 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 568815009148 E3 interaction surface; other site 568815009149 lipoyl attachment site [posttranslational modification]; other site 568815009150 e3 binding domain; Region: E3_binding; pfam02817 568815009151 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 568815009152 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 568815009153 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 568815009154 TPP-binding site [chemical binding]; other site 568815009155 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 568815009156 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 568815009157 CoA binding domain; Region: CoA_binding; smart00881 568815009158 CoA-ligase; Region: Ligase_CoA; pfam00549 568815009159 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 568815009160 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 568815009161 CoA-ligase; Region: Ligase_CoA; pfam00549 568815009162 malate dehydrogenase; Reviewed; Region: PRK06223 568815009163 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 568815009164 NAD(P) binding site [chemical binding]; other site 568815009165 dimer interface [polypeptide binding]; other site 568815009166 tetramer (dimer of dimers) interface [polypeptide binding]; other site 568815009167 substrate binding site [chemical binding]; other site 568815009168 Predicted ATPase [General function prediction only]; Region: COG1485 568815009169 Protease inhibitor Inh; Region: Inh; pfam02974 568815009170 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 568815009171 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 568815009172 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 568815009173 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 568815009174 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 568815009175 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568815009176 FeS/SAM binding site; other site 568815009177 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 568815009178 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 568815009179 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 568815009180 intracellular septation protein A; Reviewed; Region: PRK00259 568815009181 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 568815009182 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 568815009183 active site 568815009184 8-oxo-dGMP binding site [chemical binding]; other site 568815009185 nudix motif; other site 568815009186 metal binding site [ion binding]; metal-binding site 568815009187 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568815009188 Coenzyme A binding pocket [chemical binding]; other site 568815009189 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 568815009190 heterotetramer interface [polypeptide binding]; other site 568815009191 active site pocket [active] 568815009192 cleavage site 568815009193 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 568815009194 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 568815009195 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 568815009196 DEAD/DEAH box helicase; Region: DEAD; pfam00270 568815009197 ATP binding site [chemical binding]; other site 568815009198 putative Mg++ binding site [ion binding]; other site 568815009199 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 568815009200 SEC-C motif; Region: SEC-C; pfam02810 568815009201 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 568815009202 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 568815009203 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 568815009204 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 568815009205 Sulfatase; Region: Sulfatase; pfam00884 568815009206 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568815009207 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568815009208 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568815009209 dimerization interface [polypeptide binding]; other site 568815009210 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568815009211 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568815009212 substrate binding pocket [chemical binding]; other site 568815009213 membrane-bound complex binding site; other site 568815009214 hinge residues; other site 568815009215 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568815009216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815009217 dimer interface [polypeptide binding]; other site 568815009218 conserved gate region; other site 568815009219 putative PBP binding loops; other site 568815009220 ABC-ATPase subunit interface; other site 568815009221 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568815009222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815009223 dimer interface [polypeptide binding]; other site 568815009224 conserved gate region; other site 568815009225 putative PBP binding loops; other site 568815009226 ABC-ATPase subunit interface; other site 568815009227 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 568815009228 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 568815009229 Walker A/P-loop; other site 568815009230 ATP binding site [chemical binding]; other site 568815009231 Q-loop/lid; other site 568815009232 ABC transporter signature motif; other site 568815009233 Walker B; other site 568815009234 D-loop; other site 568815009235 H-loop/switch region; other site 568815009236 agmatinase; Region: agmatinase; TIGR01230 568815009237 Agmatinase and related proteins; Region: Agmatinase_like_1; cd11589 568815009238 oligomer interface [polypeptide binding]; other site 568815009239 active site 568815009240 Mn binding site [ion binding]; other site 568815009241 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 568815009242 Aspartase; Region: Aspartase; cd01357 568815009243 active sites [active] 568815009244 tetramer interface [polypeptide binding]; other site 568815009245 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 568815009246 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 568815009247 Walker A/P-loop; other site 568815009248 ATP binding site [chemical binding]; other site 568815009249 Q-loop/lid; other site 568815009250 ABC transporter signature motif; other site 568815009251 Walker B; other site 568815009252 D-loop; other site 568815009253 H-loop/switch region; other site 568815009254 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 568815009255 active site 568815009256 homotetramer interface [polypeptide binding]; other site 568815009257 homodimer interface [polypeptide binding]; other site 568815009258 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568815009259 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568815009260 DNA-binding site [nucleotide binding]; DNA binding site 568815009261 FCD domain; Region: FCD; pfam07729 568815009262 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 568815009263 active site 568815009264 homotetramer interface [polypeptide binding]; other site 568815009265 homodimer interface [polypeptide binding]; other site 568815009266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568815009267 D-galactonate transporter; Region: 2A0114; TIGR00893 568815009268 putative substrate translocation pore; other site 568815009269 methionine gamma-lyase; Validated; Region: PRK07049 568815009270 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 568815009271 homodimer interface [polypeptide binding]; other site 568815009272 substrate-cofactor binding pocket; other site 568815009273 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568815009274 catalytic residue [active] 568815009275 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 568815009276 Ligand Binding Site [chemical binding]; other site 568815009277 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 568815009278 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 568815009279 dimer interface [polypeptide binding]; other site 568815009280 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568815009281 catalytic residue [active] 568815009282 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 568815009283 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 568815009284 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 568815009285 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 568815009286 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 568815009287 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 568815009288 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 568815009289 Ligand binding site [chemical binding]; other site 568815009290 Electron transfer flavoprotein domain; Region: ETF; pfam01012 568815009291 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 568815009292 Ligand Binding Site [chemical binding]; other site 568815009293 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 568815009294 active site 568815009295 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 568815009296 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 568815009297 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 568815009298 Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588 568815009299 short chain dehydrogenase; Provisional; Region: PRK05993 568815009300 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 568815009301 NADP binding site [chemical binding]; other site 568815009302 active site 568815009303 steroid binding site; other site 568815009304 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 568815009305 hypothetical protein; Validated; Region: PRK00124 568815009306 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 568815009307 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 568815009308 catalytic residues [active] 568815009309 argininosuccinate lyase; Provisional; Region: PRK00855 568815009310 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 568815009311 active sites [active] 568815009312 tetramer interface [polypeptide binding]; other site 568815009313 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 568815009314 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 568815009315 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 568815009316 active site 568815009317 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 568815009318 substrate binding site [chemical binding]; other site 568815009319 catalytic residues [active] 568815009320 dimer interface [polypeptide binding]; other site 568815009321 TIGR02302 family protein; Region: aProt_lowcomp 568815009322 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568815009323 active site 568815009324 Methyltransferase domain; Region: Methyltransf_23; pfam13489 568815009325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568815009326 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 568815009327 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568815009328 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568815009329 homodimer interface [polypeptide binding]; other site 568815009330 catalytic residue [active] 568815009331 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 568815009332 prephenate dehydrogenase; Validated; Region: PRK08507 568815009333 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093 568815009334 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 568815009335 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 568815009336 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 568815009337 putative active site pocket [active] 568815009338 dimerization interface [polypeptide binding]; other site 568815009339 putative catalytic residue [active] 568815009340 YGGT family; Region: YGGT; pfam02325 568815009341 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 568815009342 dimer interface [polypeptide binding]; other site 568815009343 substrate binding site [chemical binding]; other site 568815009344 metal binding sites [ion binding]; metal-binding site 568815009345 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 568815009346 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 568815009347 putative acyl-acceptor binding pocket; other site 568815009348 Uncharacterized conserved protein [Function unknown]; Region: COG1434 568815009349 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 568815009350 putative active site [active] 568815009351 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 568815009352 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 568815009353 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 568815009354 Walker A/P-loop; other site 568815009355 ATP binding site [chemical binding]; other site 568815009356 Q-loop/lid; other site 568815009357 ABC transporter signature motif; other site 568815009358 Walker B; other site 568815009359 D-loop; other site 568815009360 H-loop/switch region; other site 568815009361 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 568815009362 amphipathic channel; other site 568815009363 Asn-Pro-Ala signature motifs; other site 568815009364 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 568815009365 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 568815009366 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 568815009367 putative catalytic site [active] 568815009368 putative phosphate binding site [ion binding]; other site 568815009369 active site 568815009370 metal binding site A [ion binding]; metal-binding site 568815009371 DNA binding site [nucleotide binding] 568815009372 putative AP binding site [nucleotide binding]; other site 568815009373 putative metal binding site B [ion binding]; other site 568815009374 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 568815009375 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 568815009376 ligand binding site [chemical binding]; other site 568815009377 flexible hinge region; other site 568815009378 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568815009379 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568815009380 active site 568815009381 phosphorylation site [posttranslational modification] 568815009382 intermolecular recognition site; other site 568815009383 dimerization interface [polypeptide binding]; other site 568815009384 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568815009385 DNA binding site [nucleotide binding] 568815009386 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 568815009387 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 568815009388 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 568815009389 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 568815009390 Autotransporter beta-domain; Region: Autotransporter; smart00869 568815009391 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 568815009392 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 568815009393 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 568815009394 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 568815009395 DNA binding residues [nucleotide binding] 568815009396 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 568815009397 dimer interface [polypeptide binding]; other site 568815009398 putative metal binding site [ion binding]; other site 568815009399 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 568815009400 metal-binding site [ion binding] 568815009401 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 568815009402 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 568815009403 metal-binding site [ion binding] 568815009404 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568815009405 Soluble P-type ATPase [General function prediction only]; Region: COG4087 568815009406 Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase) [Coenzyme metabolism]; Region: CobT; COG4547 568815009407 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 568815009408 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 568815009409 metal ion-dependent adhesion site (MIDAS); other site 568815009410 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 568815009411 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 568815009412 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 568815009413 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 568815009414 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 568815009415 HSP70 interaction site [polypeptide binding]; other site 568815009416 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 568815009417 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 568815009418 Domain of unknown function DUF21; Region: DUF21; pfam01595 568815009419 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 568815009420 Transporter associated domain; Region: CorC_HlyC; smart01091 568815009421 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 568815009422 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 568815009423 active site 568815009424 dimer interface [polypeptide binding]; other site 568815009425 metal binding site [ion binding]; metal-binding site 568815009426 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 568815009427 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 568815009428 ADP binding site [chemical binding]; other site 568815009429 magnesium binding site [ion binding]; other site 568815009430 putative shikimate binding site; other site 568815009431 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 568815009432 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 568815009433 active site 568815009434 DNA binding site [nucleotide binding] 568815009435 Int/Topo IB signature motif; other site 568815009436 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 568815009437 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 568815009438 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 568815009439 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 568815009440 CPxP motif; other site 568815009441 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 568815009442 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 568815009443 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 568815009444 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 568815009445 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 568815009446 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 568815009447 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568815009448 NAD(P) binding site [chemical binding]; other site 568815009449 active site 568815009450 Uncharacterized conserved protein [Function unknown]; Region: COG3791 568815009451 Domain of unknown function (DUF4354); Region: DUF4354; pfam14263 568815009452 choline dehydrogenase; Validated; Region: PRK02106 568815009453 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 568815009454 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 568815009455 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568815009456 NAD(P) binding site [chemical binding]; other site 568815009457 active site 568815009458 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 568815009459 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 568815009460 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 568815009461 Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118 568815009462 NAD(P) binding site [chemical binding]; other site 568815009463 catalytic residues [active] 568815009464 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 568815009465 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568815009466 substrate binding site [chemical binding]; other site 568815009467 oxyanion hole (OAH) forming residues; other site 568815009468 trimer interface [polypeptide binding]; other site 568815009469 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 568815009470 Coenzyme A transferase; Region: CoA_trans; smart00882 568815009471 Coenzyme A transferase; Region: CoA_trans; cl17247 568815009472 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 568815009473 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 568815009474 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 568815009475 Transcriptional regulators [Transcription]; Region: PurR; COG1609 568815009476 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568815009477 DNA binding site [nucleotide binding] 568815009478 domain linker motif; other site 568815009479 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 568815009480 putative dimerization interface [polypeptide binding]; other site 568815009481 putative ligand binding site [chemical binding]; other site 568815009482 Protein of unknown function (DUF993); Region: DUF993; pfam06187 568815009483 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 568815009484 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 568815009485 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 568815009486 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 568815009487 zinc binding site [ion binding]; other site 568815009488 putative ligand binding site [chemical binding]; other site 568815009489 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568815009490 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 568815009491 TM-ABC transporter signature motif; other site 568815009492 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 568815009493 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 568815009494 Walker A/P-loop; other site 568815009495 ATP binding site [chemical binding]; other site 568815009496 Q-loop/lid; other site 568815009497 ABC transporter signature motif; other site 568815009498 Walker B; other site 568815009499 D-loop; other site 568815009500 H-loop/switch region; other site 568815009501 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 568815009502 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 568815009503 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 568815009504 ParB-like nuclease domain; Region: ParB; smart00470 568815009505 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 568815009506 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 568815009507 P-loop; other site 568815009508 Magnesium ion binding site [ion binding]; other site 568815009509 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 568815009510 Magnesium ion binding site [ion binding]; other site 568815009511 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 568815009512 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 568815009513 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 568815009514 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 568815009515 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 568815009516 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 568815009517 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 568815009518 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 568815009519 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 568815009520 trmE is a tRNA modification GTPase; Region: trmE; cd04164 568815009521 G1 box; other site 568815009522 G1 box; other site 568815009523 GTP/Mg2+ binding site [chemical binding]; other site 568815009524 GTP/Mg2+ binding site [chemical binding]; other site 568815009525 Switch I region; other site 568815009526 Switch I region; other site 568815009527 G2 box; other site 568815009528 G2 box; other site 568815009529 Switch II region; other site 568815009530 G3 box; other site 568815009531 G4 box; other site 568815009532 G5 box; other site 568815009533 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 568815009534 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 568815009535 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 568815009536 catalytic residues [active] 568815009537 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 568815009538 transcription termination factor Rho; Provisional; Region: rho; PRK09376 568815009539 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 568815009540 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 568815009541 RNA binding site [nucleotide binding]; other site 568815009542 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 568815009543 multimer interface [polypeptide binding]; other site 568815009544 Walker A motif; other site 568815009545 ATP binding site [chemical binding]; other site 568815009546 Walker B motif; other site 568815009547 Predicted membrane protein [Function unknown]; Region: COG1981 568815009548 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 568815009549 substrate binding site [chemical binding]; other site 568815009550 active site 568815009551 PEP synthetase regulatory protein; Provisional; Region: PRK05339 568815009552 Maf-like protein; Reviewed; Region: PRK00078 568815009553 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 568815009554 active site 568815009555 dimer interface [polypeptide binding]; other site 568815009556 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 568815009557 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 568815009558 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 568815009559 shikimate binding site; other site 568815009560 NAD(P) binding site [chemical binding]; other site 568815009561 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 568815009562 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 568815009563 CoA-binding site [chemical binding]; other site 568815009564 ATP-binding [chemical binding]; other site 568815009565 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 568815009566 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 568815009567 active site 568815009568 catalytic site [active] 568815009569 substrate binding site [chemical binding]; other site 568815009570 preprotein translocase subunit SecB; Validated; Region: PRK05751 568815009571 SecA binding site; other site 568815009572 Preprotein binding site; other site 568815009573 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 568815009574 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 568815009575 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 568815009576 MltA specific insert domain; Region: MltA; pfam03562 568815009577 3D domain; Region: 3D; pfam06725 568815009578 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 568815009579 Smr domain; Region: Smr; pfam01713 568815009580 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568815009581 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568815009582 sequence-specific DNA binding site [nucleotide binding]; other site 568815009583 salt bridge; other site 568815009584 Protein of unknown function (DUF1402); Region: DUF1402; pfam07182 568815009585 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 568815009586 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568815009587 Walker A motif; other site 568815009588 ATP binding site [chemical binding]; other site 568815009589 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 568815009590 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 568815009591 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 568815009592 active site 568815009593 HslU subunit interaction site [polypeptide binding]; other site 568815009594 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 568815009595 putative active site pocket [active] 568815009596 4-fold oligomerization interface [polypeptide binding]; other site 568815009597 metal binding residues [ion binding]; metal-binding site 568815009598 3-fold/trimer interface [polypeptide binding]; other site 568815009599 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 568815009600 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 568815009601 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 568815009602 putative active site [active] 568815009603 oxyanion strand; other site 568815009604 catalytic triad [active] 568815009605 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 568815009606 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 568815009607 catalytic residues [active] 568815009608 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 568815009609 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 568815009610 substrate binding site [chemical binding]; other site 568815009611 glutamase interaction surface [polypeptide binding]; other site 568815009612 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 568815009613 metal binding site [ion binding]; metal-binding site 568815009614 pantothenate kinase; Provisional; Region: PRK05439 568815009615 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 568815009616 ATP-binding site [chemical binding]; other site 568815009617 CoA-binding site [chemical binding]; other site 568815009618 Mg2+-binding site [ion binding]; other site 568815009619 hypothetical protein; Provisional; Region: PRK09256 568815009620 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 568815009621 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 568815009622 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 568815009623 active site 568815009624 substrate-binding site [chemical binding]; other site 568815009625 metal-binding site [ion binding] 568815009626 ATP binding site [chemical binding]; other site 568815009627 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568815009628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568815009629 active site 568815009630 phosphorylation site [posttranslational modification] 568815009631 intermolecular recognition site; other site 568815009632 dimerization interface [polypeptide binding]; other site 568815009633 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568815009634 DNA binding site [nucleotide binding] 568815009635 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 568815009636 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 568815009637 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568815009638 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 568815009639 dimerization interface [polypeptide binding]; other site 568815009640 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568815009641 dimer interface [polypeptide binding]; other site 568815009642 phosphorylation site [posttranslational modification] 568815009643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568815009644 ATP binding site [chemical binding]; other site 568815009645 Mg2+ binding site [ion binding]; other site 568815009646 G-X-G motif; other site 568815009647 Serine kinase of the HPr protein, regulates carbohydrate metabolism [Signal transduction mechanisms]; Region: HprK; COG1493 568815009648 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 568815009649 Hpr binding site; other site 568815009650 active site 568815009651 homohexamer subunit interaction site [polypeptide binding]; other site 568815009652 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 568815009653 active pocket/dimerization site; other site 568815009654 active site 568815009655 phosphorylation site [posttranslational modification] 568815009656 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 568815009657 dimerization domain swap beta strand [polypeptide binding]; other site 568815009658 regulatory protein interface [polypeptide binding]; other site 568815009659 active site 568815009660 regulatory phosphorylation site [posttranslational modification]; other site 568815009661 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 568815009662 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 568815009663 homotetramer interface [polypeptide binding]; other site 568815009664 ligand binding site [chemical binding]; other site 568815009665 catalytic site [active] 568815009666 NAD binding site [chemical binding]; other site 568815009667 PAS fold; Region: PAS_7; pfam12860 568815009668 PAS fold; Region: PAS_7; pfam12860 568815009669 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568815009670 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568815009671 dimer interface [polypeptide binding]; other site 568815009672 phosphorylation site [posttranslational modification] 568815009673 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568815009674 ATP binding site [chemical binding]; other site 568815009675 Mg2+ binding site [ion binding]; other site 568815009676 G-X-G motif; other site 568815009677 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 568815009678 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 568815009679 Phosphotransferase enzyme family; Region: APH; pfam01636 568815009680 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 568815009681 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 568815009682 Substrate binding site; other site 568815009683 metal-binding site 568815009684 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 568815009685 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 568815009686 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 568815009687 Part of AAA domain; Region: AAA_19; pfam13245 568815009688 Family description; Region: UvrD_C_2; pfam13538 568815009689 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 568815009690 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 568815009691 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 568815009692 catalytic residues [active] 568815009693 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 568815009694 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568815009695 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 568815009696 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 568815009697 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 568815009698 substrate binding site [chemical binding]; other site 568815009699 active site 568815009700 catalytic residues [active] 568815009701 heterodimer interface [polypeptide binding]; other site 568815009702 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 568815009703 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 568815009704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568815009705 catalytic residue [active] 568815009706 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 568815009707 active site 568815009708 Uncharacterized conserved protein [Function unknown]; Region: COG1434 568815009709 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 568815009710 putative active site [active] 568815009711 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 568815009712 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 568815009713 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 568815009714 benzoate transporter; Region: benE; TIGR00843 568815009715 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 568815009716 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 568815009717 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 568815009718 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 568815009719 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 568815009720 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 568815009721 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 568815009722 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 568815009723 23S rRNA binding site [nucleotide binding]; other site 568815009724 L21 binding site [polypeptide binding]; other site 568815009725 L13 binding site [polypeptide binding]; other site 568815009726 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 568815009727 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 568815009728 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 568815009729 dimer interface [polypeptide binding]; other site 568815009730 motif 1; other site 568815009731 active site 568815009732 motif 2; other site 568815009733 motif 3; other site 568815009734 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 568815009735 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 568815009736 putative tRNA-binding site [nucleotide binding]; other site 568815009737 B3/4 domain; Region: B3_4; pfam03483 568815009738 tRNA synthetase B5 domain; Region: B5; smart00874 568815009739 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 568815009740 dimer interface [polypeptide binding]; other site 568815009741 motif 1; other site 568815009742 motif 3; other site 568815009743 motif 2; other site 568815009744 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 568815009745 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 568815009746 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 568815009747 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 568815009748 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 568815009749 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 568815009750 nucleotide binding site [chemical binding]; other site 568815009751 NEF interaction site [polypeptide binding]; other site 568815009752 SBD interface [polypeptide binding]; other site 568815009753 chaperone protein DnaJ; Provisional; Region: PRK10767 568815009754 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 568815009755 HSP70 interaction site [polypeptide binding]; other site 568815009756 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 568815009757 substrate binding site [polypeptide binding]; other site 568815009758 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 568815009759 Zn binding sites [ion binding]; other site 568815009760 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 568815009761 dimer interface [polypeptide binding]; other site 568815009762 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568815009763 S-adenosylmethionine binding site [chemical binding]; other site 568815009764 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 568815009765 active site 568815009766 dimer interface [polypeptide binding]; other site 568815009767 Uncharacterized conserved protein [Function unknown]; Region: COG5470 568815009768 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 568815009769 glutathione synthetase; Provisional; Region: PRK05246 568815009770 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 568815009771 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 568815009772 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 568815009773 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 568815009774 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 568815009775 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 568815009776 PBP superfamily domain; Region: PBP_like_2; pfam12849 568815009777 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 568815009778 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 568815009779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815009780 dimer interface [polypeptide binding]; other site 568815009781 conserved gate region; other site 568815009782 putative PBP binding loops; other site 568815009783 ABC-ATPase subunit interface; other site 568815009784 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 568815009785 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 568815009786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568815009787 dimer interface [polypeptide binding]; other site 568815009788 conserved gate region; other site 568815009789 putative PBP binding loops; other site 568815009790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 568815009791 ABC-ATPase subunit interface; other site 568815009792 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 568815009793 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 568815009794 Walker A/P-loop; other site 568815009795 ATP binding site [chemical binding]; other site 568815009796 Q-loop/lid; other site 568815009797 ABC transporter signature motif; other site 568815009798 Walker B; other site 568815009799 D-loop; other site 568815009800 H-loop/switch region; other site 568815009801 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 568815009802 PhoU domain; Region: PhoU; pfam01895 568815009803 PhoU domain; Region: PhoU; pfam01895 568815009804 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 568815009805 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568815009806 active site 568815009807 phosphorylation site [posttranslational modification] 568815009808 intermolecular recognition site; other site 568815009809 dimerization interface [polypeptide binding]; other site 568815009810 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568815009811 DNA binding site [nucleotide binding] 568815009812 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 568815009813 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 568815009814 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 568815009815 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 568815009816 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 568815009817 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 568815009818 dimerization interface [polypeptide binding]; other site 568815009819 DPS ferroxidase diiron center [ion binding]; other site 568815009820 ion pore; other site 568815009821 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 568815009822 Glycoprotease family; Region: Peptidase_M22; pfam00814 568815009823 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 568815009824 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568815009825 Coenzyme A binding pocket [chemical binding]; other site 568815009826 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 568815009827 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 568815009828 putative acyl-acceptor binding pocket; other site 568815009829 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 568815009830 PhoH-like protein; Region: PhoH; pfam02562 568815009831 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 568815009832 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 568815009833 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 568815009834 Transporter associated domain; Region: CorC_HlyC; smart01091 568815009835 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 568815009836 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 568815009837 putative active site [active] 568815009838 catalytic triad [active] 568815009839 putative dimer interface [polypeptide binding]; other site 568815009840 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568815009841 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568815009842 non-specific DNA binding site [nucleotide binding]; other site 568815009843 salt bridge; other site 568815009844 sequence-specific DNA binding site [nucleotide binding]; other site 568815009845 S-adenosylmethionine synthetase; Validated; Region: PRK05250 568815009846 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 568815009847 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 568815009848 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 568815009849 Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220 568815009850 ribosome maturation protein RimP; Reviewed; Region: PRK00092 568815009851 Sm and related proteins; Region: Sm_like; cl00259 568815009852 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 568815009853 putative oligomer interface [polypeptide binding]; other site 568815009854 putative RNA binding site [nucleotide binding]; other site 568815009855 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 568815009856 NusA N-terminal domain; Region: NusA_N; pfam08529 568815009857 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 568815009858 RNA binding site [nucleotide binding]; other site 568815009859 homodimer interface [polypeptide binding]; other site 568815009860 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 568815009861 G-X-X-G motif; other site 568815009862 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 568815009863 G-X-X-G motif; other site 568815009864 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 568815009865 hypothetical protein; Provisional; Region: PRK09190 568815009866 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 568815009867 putative RNA binding cleft [nucleotide binding]; other site 568815009868 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 568815009869 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 568815009870 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 568815009871 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 568815009872 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 568815009873 G1 box; other site 568815009874 putative GEF interaction site [polypeptide binding]; other site 568815009875 GTP/Mg2+ binding site [chemical binding]; other site 568815009876 Switch I region; other site 568815009877 G2 box; other site 568815009878 G3 box; other site 568815009879 Switch II region; other site 568815009880 G4 box; other site 568815009881 G5 box; other site 568815009882 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 568815009883 Translation-initiation factor 2; Region: IF-2; pfam11987 568815009884 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 568815009885 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 568815009886 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 568815009887 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 568815009888 RNA binding site [nucleotide binding]; other site 568815009889 active site 568815009890 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 568815009891 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 568815009892 16S/18S rRNA binding site [nucleotide binding]; other site 568815009893 S13e-L30e interaction site [polypeptide binding]; other site 568815009894 25S rRNA binding site [nucleotide binding]; other site 568815009895 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 568815009896 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 568815009897 RNase E interface [polypeptide binding]; other site 568815009898 trimer interface [polypeptide binding]; other site 568815009899 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 568815009900 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 568815009901 RNase E interface [polypeptide binding]; other site 568815009902 trimer interface [polypeptide binding]; other site 568815009903 active site 568815009904 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 568815009905 putative nucleic acid binding region [nucleotide binding]; other site 568815009906 G-X-X-G motif; other site 568815009907 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 568815009908 RNA binding site [nucleotide binding]; other site 568815009909 domain interface; other site 568815009910 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 568815009911 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568815009912 S-adenosylmethionine binding site [chemical binding]; other site 568815009913 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505 568815009914 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 568815009915 NAD binding site [chemical binding]; other site 568815009916 homotetramer interface [polypeptide binding]; other site 568815009917 homodimer interface [polypeptide binding]; other site 568815009918 substrate binding site [chemical binding]; other site 568815009919 active site 568815009920 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 568815009921 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 568815009922 dimer interface [polypeptide binding]; other site 568815009923 active site 568815009924 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 568815009925 active site 1 [active] 568815009926 dimer interface [polypeptide binding]; other site 568815009927 active site 2 [active] 568815009928 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 568815009929 metal binding site 2 [ion binding]; metal-binding site 568815009930 putative DNA binding helix; other site 568815009931 metal binding site 1 [ion binding]; metal-binding site 568815009932 dimer interface [polypeptide binding]; other site 568815009933 structural Zn2+ binding site [ion binding]; other site 568815009934 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 568815009935 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 568815009936 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 568815009937 Bacterial SH3 domain; Region: SH3_4; pfam06347 568815009938 Bacterial SH3 domain; Region: SH3_4; pfam06347 568815009939 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 568815009940 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 568815009941 dimerization interface [polypeptide binding]; other site 568815009942 ligand binding site [chemical binding]; other site 568815009943 NADP binding site [chemical binding]; other site 568815009944 catalytic site [active] 568815009945 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 568815009946 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 568815009947 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 568815009948 NlpC/P60 family; Region: NLPC_P60; cl17555 568815009949 Transcriptional regulators [Transcription]; Region: MarR; COG1846 568815009950 MarR family; Region: MarR; pfam01047 568815009951 multifunctional aminopeptidase A; Provisional; Region: PRK00913 568815009952 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 568815009953 interface (dimer of trimers) [polypeptide binding]; other site 568815009954 Substrate-binding/catalytic site; other site 568815009955 Zn-binding sites [ion binding]; other site 568815009956 Flp/Fap pilin component; Region: Flp_Fap; cl01585 568815009957 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 568815009958 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 568815009959 DNA binding site [nucleotide binding] 568815009960 catalytic residue [active] 568815009961 H2TH interface [polypeptide binding]; other site 568815009962 putative catalytic residues [active] 568815009963 turnover-facilitating residue; other site 568815009964 intercalation triad [nucleotide binding]; other site 568815009965 8OG recognition residue [nucleotide binding]; other site 568815009966 putative reading head residues; other site 568815009967 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 568815009968 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 568815009969 enoyl-CoA hydratase; Provisional; Region: PRK05862 568815009970 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568815009971 substrate binding site [chemical binding]; other site 568815009972 oxyanion hole (OAH) forming residues; other site 568815009973 trimer interface [polypeptide binding]; other site 568815009974 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239