-- dump date   	20140618_235940
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1415784000001	Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279
1415784000002	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1415784000003	Domain of unknown function (DUF1963); Region: DUF1963; cl01600
1415784000004	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
1415784000005	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
1415784000006	MepB protein; Region: MepB; pfam08877
1415784000007	Domain of unknown function (DUF4180); Region: DUF4180; pfam13788
1415784000008	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1415784000009	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1415784000010	motif II; other site
1415784000011	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
1415784000012	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784000013	active site
1415784000014	phosphorylation site [posttranslational modification]
1415784000015	intermolecular recognition site; other site
1415784000016	dimerization interface [polypeptide binding]; other site
1415784000017	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1415784000018	DNA binding site [nucleotide binding]
1415784000019	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1415784000020	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1415784000021	dimerization interface [polypeptide binding]; other site
1415784000022	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1415784000023	dimer interface [polypeptide binding]; other site
1415784000024	phosphorylation site [posttranslational modification]
1415784000025	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784000026	ATP binding site [chemical binding]; other site
1415784000027	Mg2+ binding site [ion binding]; other site
1415784000028	G-X-G motif; other site
1415784000029	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
1415784000030	nudix motif; other site
1415784000031	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1415784000032	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1415784000033	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1415784000034	Walker A/P-loop; other site
1415784000035	ATP binding site [chemical binding]; other site
1415784000036	Q-loop/lid; other site
1415784000037	ABC transporter signature motif; other site
1415784000038	Walker B; other site
1415784000039	D-loop; other site
1415784000040	H-loop/switch region; other site
1415784000041	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
1415784000042	FtsX-like permease family; Region: FtsX; pfam02687
1415784000043	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1415784000044	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784000045	Coenzyme A binding pocket [chemical binding]; other site
1415784000046	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1415784000047	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1415784000048	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1415784000049	tyrosine decarboxylase; Region: PLN02880
1415784000050	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1415784000051	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1415784000052	catalytic residue [active]
1415784000053	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1415784000054	CoA binding site [chemical binding]; other site
1415784000055	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1415784000056	Condensation domain; Region: Condensation; pfam00668
1415784000057	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1415784000058	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1415784000059	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1415784000060	acyl-activating enzyme (AAE) consensus motif; other site
1415784000061	AMP binding site [chemical binding]; other site
1415784000062	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1415784000063	Condensation domain; Region: Condensation; pfam00668
1415784000064	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1415784000065	Nonribosomal peptide synthase; Region: NRPS; pfam08415
1415784000066	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1415784000067	acyl-activating enzyme (AAE) consensus motif; other site
1415784000068	CoA binding site [chemical binding]; other site
1415784000069	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
1415784000070	putative FMN binding site [chemical binding]; other site
1415784000071	NADPH bind site [chemical binding]; other site
1415784000072	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
1415784000073	carbohydrate binding site [chemical binding]; other site
1415784000074	pullulanase, type I; Region: pulA_typeI; TIGR02104
1415784000075	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
1415784000076	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
1415784000077	Ca binding site [ion binding]; other site
1415784000078	active site
1415784000079	catalytic site [active]
1415784000080	Domain of unknown function (DUF3372); Region: DUF3372; pfam11852
1415784000081	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1415784000082	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
1415784000083	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
1415784000084	active site
1415784000085	Zn binding site [ion binding]; other site
1415784000086	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1415784000087	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
1415784000088	active site
1415784000089	metal binding site [ion binding]; metal-binding site
1415784000090	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1415784000091	DinB superfamily; Region: DinB_2; pfam12867
1415784000092	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907
1415784000093	SecY translocase; Region: SecY; pfam00344
1415784000094	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
1415784000095	EamA-like transporter family; Region: EamA; pfam00892
1415784000096	EamA-like transporter family; Region: EamA; pfam00892
1415784000097	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1415784000098	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1415784000099	DNA-binding site [nucleotide binding]; DNA binding site
1415784000100	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1415784000101	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784000102	homodimer interface [polypeptide binding]; other site
1415784000103	catalytic residue [active]
1415784000104	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1415784000105	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1415784000106	putative NAD(P) binding site [chemical binding]; other site
1415784000107	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1415784000108	TAP-like protein; Region: Abhydrolase_4; pfam08386
1415784000109	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
1415784000110	Mg binding site [ion binding]; other site
1415784000111	nucleotide binding site [chemical binding]; other site
1415784000112	putative protofilament interface [polypeptide binding]; other site
1415784000113	Protein of unknown function (DUF1697); Region: DUF1697; pfam08002
1415784000114	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1415784000115	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
1415784000116	sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898
1415784000117	germination protein YpeB; Region: spore_YpeB; TIGR02889
1415784000118	spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869
1415784000119	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1415784000120	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
1415784000121	Protein of unknown function (DUF3889); Region: DUF3889; pfam13028
1415784000122	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1415784000123	Beta-lactamase; Region: Beta-lactamase; pfam00144
1415784000124	tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036
1415784000125	arylformamidase; Region: trp_arylform; TIGR03035
1415784000126	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1415784000127	kynureninase; Region: kynureninase; TIGR01814
1415784000128	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1415784000129	catalytic residue [active]
1415784000130	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1415784000131	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1415784000132	Protein of unknown function (DUF3977); Region: DUF3977; pfam13122
1415784000133	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
1415784000134	GAF domain; Region: GAF; pfam01590
1415784000135	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1415784000136	Walker A motif; other site
1415784000137	ATP binding site [chemical binding]; other site
1415784000138	Walker B motif; other site
1415784000139	arginine finger; other site
1415784000140	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1415784000141	NIPSNAP; Region: NIPSNAP; pfam07978
1415784000142	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
1415784000143	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784000144	Coenzyme A binding pocket [chemical binding]; other site
1415784000145	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1415784000146	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1415784000147	putative DNA binding site [nucleotide binding]; other site
1415784000148	putative Zn2+ binding site [ion binding]; other site
1415784000149	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1415784000150	Protein of unknown function (DUF4085); Region: DUF4085; pfam13315
1415784000151	dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912
1415784000152	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1415784000153	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1415784000154	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1415784000155	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1415784000156	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1415784000157	E3 interaction surface; other site
1415784000158	lipoyl attachment site [posttranslational modification]; other site
1415784000159	e3 binding domain; Region: E3_binding; pfam02817
1415784000160	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1415784000161	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1415784000162	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1415784000163	alpha subunit interface [polypeptide binding]; other site
1415784000164	TPP binding site [chemical binding]; other site
1415784000165	heterodimer interface [polypeptide binding]; other site
1415784000166	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1415784000167	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
1415784000168	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1415784000169	tetramer interface [polypeptide binding]; other site
1415784000170	TPP-binding site [chemical binding]; other site
1415784000171	heterodimer interface [polypeptide binding]; other site
1415784000172	phosphorylation loop region [posttranslational modification]
1415784000173	DinB superfamily; Region: DinB_2; pfam12867
1415784000174	Protein of unknown function (DUF1572); Region: DUF1572; pfam07609
1415784000175	short chain dehydrogenase; Provisional; Region: PRK06914
1415784000176	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1415784000177	NADP binding site [chemical binding]; other site
1415784000178	active site
1415784000179	steroid binding site; other site
1415784000180	Domain of unknown function (DUF4181); Region: DUF4181; pfam13789
1415784000181	Protein phosphatase 2C; Region: PP2C_2; pfam13672
1415784000182	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
1415784000183	nucleotide binding site/active site [active]
1415784000184	HIT family signature motif; other site
1415784000185	catalytic residue [active]
1415784000186	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784000187	dimer interface [polypeptide binding]; other site
1415784000188	conserved gate region; other site
1415784000189	putative PBP binding loops; other site
1415784000190	ABC-ATPase subunit interface; other site
1415784000191	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
1415784000192	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
1415784000193	Walker A/P-loop; other site
1415784000194	ATP binding site [chemical binding]; other site
1415784000195	Q-loop/lid; other site
1415784000196	ABC transporter signature motif; other site
1415784000197	Walker B; other site
1415784000198	D-loop; other site
1415784000199	H-loop/switch region; other site
1415784000200	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
1415784000201	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
1415784000202	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1415784000203	Clp protease; Region: CLP_protease; pfam00574
1415784000204	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1415784000205	oligomer interface [polypeptide binding]; other site
1415784000206	active site residues [active]
1415784000207	RNA polymerase factor sigma-70; Validated; Region: PRK06704
1415784000208	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1415784000209	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1415784000210	DNA binding residues [nucleotide binding]
1415784000211	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1415784000212	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1415784000213	catalytic loop [active]
1415784000214	iron binding site [ion binding]; other site
1415784000215	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1415784000216	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1415784000217	active site
1415784000218	dimer interface [polypeptide binding]; other site
1415784000219	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784000220	Coenzyme A binding pocket [chemical binding]; other site
1415784000221	Chitin binding domain; Region: Chitin_bind_3; pfam03067
1415784000222	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1415784000223	Interdomain contacts; other site
1415784000224	Cytokine receptor motif; other site
1415784000225	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1415784000226	Interdomain contacts; other site
1415784000227	Cytokine receptor motif; other site
1415784000228	Carbohydrate binding domain; Region: CBM_5_12; pfam02839
1415784000229	aromatic chitin/cellulose binding site residues [chemical binding]; other site
1415784000230	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1415784000231	glycosyltransferase, MGT family; Region: MGT; TIGR01426
1415784000232	active site
1415784000233	TDP-binding site; other site
1415784000234	acceptor substrate-binding pocket; other site
1415784000235	homodimer interface [polypeptide binding]; other site
1415784000236	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1415784000237	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1415784000238	topology modulation protein; Reviewed; Region: PRK08118
1415784000239	AAA domain; Region: AAA_17; pfam13207
1415784000240	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1415784000241	active site
1415784000242	ATP binding site [chemical binding]; other site
1415784000243	Phosphotransferase enzyme family; Region: APH; pfam01636
1415784000244	substrate binding site [chemical binding]; other site
1415784000245	Protein of unknown function (DUF2809); Region: DUF2809; pfam10990
1415784000246	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784000247	S-adenosylmethionine binding site [chemical binding]; other site
1415784000248	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
1415784000249	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784000250	Coenzyme A binding pocket [chemical binding]; other site
1415784000251	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784000252	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1415784000253	Coenzyme A binding pocket [chemical binding]; other site
1415784000254	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1415784000255	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1415784000256	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784000257	Coenzyme A binding pocket [chemical binding]; other site
1415784000258	Predicted transcriptional regulators [Transcription]; Region: COG1695
1415784000259	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1415784000260	Protein of unknown function (DUF952); Region: DUF952; pfam06108
1415784000261	Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757
1415784000262	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
1415784000263	Part of AAA domain; Region: AAA_19; pfam13245
1415784000264	Family description; Region: UvrD_C_2; pfam13538
1415784000265	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1415784000266	putative active site pocket [active]
1415784000267	dimerization interface [polypeptide binding]; other site
1415784000268	putative catalytic residue [active]
1415784000269	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
1415784000270	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1415784000271	ATP binding site [chemical binding]; other site
1415784000272	putative Mg++ binding site [ion binding]; other site
1415784000273	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1415784000274	nucleotide binding region [chemical binding]; other site
1415784000275	ATP-binding site [chemical binding]; other site
1415784000276	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
1415784000277	HRDC domain; Region: HRDC; pfam00570
1415784000278	Protein of unknown function (DUF4017); Region: DUF4017; pfam13209
1415784000279	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
1415784000280	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1415784000281	DHHA2 domain; Region: DHHA2; pfam02833
1415784000282	Chitin binding domain; Region: Chitin_bind_3; pfam03067
1415784000283	DinB family; Region: DinB; cl17821
1415784000284	DinB superfamily; Region: DinB_2; pfam12867
1415784000285	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1415784000286	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784000287	Coenzyme A binding pocket [chemical binding]; other site
1415784000288	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1415784000289	Zn2+ binding site [ion binding]; other site
1415784000290	Mg2+ binding site [ion binding]; other site
1415784000291	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1415784000292	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1415784000293	amino acid carrier protein; Region: agcS; TIGR00835
1415784000294	ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091
1415784000295	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1415784000296	NAD(P) binding site [chemical binding]; other site
1415784000297	catalytic residues [active]
1415784000298	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1415784000299	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1415784000300	inhibitor site; inhibition site
1415784000301	active site
1415784000302	dimer interface [polypeptide binding]; other site
1415784000303	catalytic residue [active]
1415784000304	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
1415784000305	Proline racemase; Region: Pro_racemase; pfam05544
1415784000306	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
1415784000307	Proline racemase; Region: Pro_racemase; pfam05544
1415784000308	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1415784000309	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1415784000310	PAS domain; Region: PAS; smart00091
1415784000311	PAS domain; Region: PAS_10; pfam13596
1415784000312	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
1415784000313	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1415784000314	Walker A motif; other site
1415784000315	ATP binding site [chemical binding]; other site
1415784000316	Walker B motif; other site
1415784000317	arginine finger; other site
1415784000318	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1415784000319	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1415784000320	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1415784000321	catalytic loop [active]
1415784000322	iron binding site [ion binding]; other site
1415784000323	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1415784000324	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1415784000325	Protein of unknown function (DUF2653); Region: DUF2653; pfam10850
1415784000326	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
1415784000327	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
1415784000328	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1415784000329	active site
1415784000330	metal binding site [ion binding]; metal-binding site
1415784000331	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
1415784000332	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1415784000333	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
1415784000334	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1415784000335	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1415784000336	D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092
1415784000337	DltD N-terminal region; Region: DltD_N; pfam04915
1415784000338	DltD central region; Region: DltD_M; pfam04918
1415784000339	DltD C-terminal region; Region: DltD_C; pfam04914
1415784000340	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1415784000341	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1415784000342	peptide binding site [polypeptide binding]; other site
1415784000343	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1415784000344	NlpC/P60 family; Region: NLPC_P60; pfam00877
1415784000345	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
1415784000346	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
1415784000347	active site
1415784000348	Domain of unknown function (DUF3870); Region: DUF3870; pfam12986
1415784000349	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
1415784000350	Septum formation initiator; Region: DivIC; pfam04977
1415784000351	Domain of unknown function (DUF4279); Region: DUF4279; pfam14106
1415784000352	AAA domain; Region: AAA_17; pfam13207
1415784000353	AAA domain; Region: AAA_18; pfam13238
1415784000354	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1415784000355	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784000356	S-adenosylmethionine binding site [chemical binding]; other site
1415784000357	X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129
1415784000358	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1415784000359	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
1415784000360	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1415784000361	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1415784000362	dimerization interface [polypeptide binding]; other site
1415784000363	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1415784000364	dimer interface [polypeptide binding]; other site
1415784000365	phosphorylation site [posttranslational modification]
1415784000366	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784000367	ATP binding site [chemical binding]; other site
1415784000368	Mg2+ binding site [ion binding]; other site
1415784000369	G-X-G motif; other site
1415784000370	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1415784000371	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784000372	active site
1415784000373	phosphorylation site [posttranslational modification]
1415784000374	intermolecular recognition site; other site
1415784000375	dimerization interface [polypeptide binding]; other site
1415784000376	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1415784000377	DNA binding site [nucleotide binding]
1415784000378	DinB superfamily; Region: DinB_2; pfam12867
1415784000379	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1415784000380	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1415784000381	motif II; other site
1415784000382	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
1415784000383	Zn binding site [ion binding]; other site
1415784000384	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784000385	Coenzyme A binding pocket [chemical binding]; other site
1415784000386	EDD domain protein, DegV family; Region: DegV; TIGR00762
1415784000387	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1415784000388	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784000389	Coenzyme A binding pocket [chemical binding]; other site
1415784000390	Cytochrome P450; Region: p450; cl12078
1415784000391	GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746
1415784000392	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
1415784000393	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784000394	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1415784000395	putative substrate translocation pore; other site
1415784000396	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784000397	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
1415784000398	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
1415784000399	Protein of unknown function (DUF4004); Region: DUF4004; pfam13171
1415784000400	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
1415784000401	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
1415784000402	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
1415784000403	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784000404	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1415784000405	putative substrate translocation pore; other site
1415784000406	Domain of unknown function (DUF4309); Region: DUF4309; pfam14172
1415784000407	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
1415784000408	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455
1415784000409	active site
1415784000410	Protein of unknown function (DUF3970); Region: DUF3970; pfam13113
1415784000411	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1415784000412	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784000413	S-adenosylmethionine binding site [chemical binding]; other site
1415784000414	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784000415	putative substrate translocation pore; other site
1415784000416	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1415784000417	aspartate aminotransferase; Provisional; Region: PRK07681
1415784000418	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1415784000419	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784000420	homodimer interface [polypeptide binding]; other site
1415784000421	catalytic residue [active]
1415784000422	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1415784000423	pantothenate kinase; Provisional; Region: PRK13317
1415784000424	pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555
1415784000425	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
1415784000426	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
1415784000427	Protein of unknown function (DUF1453); Region: DUF1453; pfam07301
1415784000428	Protein of unknown function (DUF4052); Region: DUF4052; pfam13261
1415784000429	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1415784000430	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1415784000431	Walker A/P-loop; other site
1415784000432	ATP binding site [chemical binding]; other site
1415784000433	Q-loop/lid; other site
1415784000434	ABC transporter signature motif; other site
1415784000435	Walker B; other site
1415784000436	D-loop; other site
1415784000437	H-loop/switch region; other site
1415784000438	Predicted transcriptional regulators [Transcription]; Region: COG1725
1415784000439	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1415784000440	DNA-binding site [nucleotide binding]; DNA binding site
1415784000441	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1415784000442	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1415784000443	HNH endonuclease; Region: HNH_5; pfam14279
1415784000444	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
1415784000445	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1415784000446	active site
1415784000447	dimer interface [polypeptide binding]; other site
1415784000448	non-prolyl cis peptide bond; other site
1415784000449	insertion regions; other site
1415784000450	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1415784000451	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1415784000452	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1415784000453	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1415784000454	substrate binding pocket [chemical binding]; other site
1415784000455	membrane-bound complex binding site; other site
1415784000456	hinge residues; other site
1415784000457	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1415784000458	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1415784000459	Walker A/P-loop; other site
1415784000460	ATP binding site [chemical binding]; other site
1415784000461	Q-loop/lid; other site
1415784000462	ABC transporter signature motif; other site
1415784000463	Walker B; other site
1415784000464	D-loop; other site
1415784000465	H-loop/switch region; other site
1415784000466	Protein of unknown function (DUF402); Region: DUF402; pfam04167
1415784000467	Tetratrico peptide repeat; Region: TPR_5; pfam12688
1415784000468	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1415784000469	binding surface
1415784000470	TPR motif; other site
1415784000471	hypothetical protein; Provisional; Region: PRK09620
1415784000472	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522
1415784000473	putative transposase OrfB; Reviewed; Region: PHA02517
1415784000474	HTH-like domain; Region: HTH_21; pfam13276
1415784000475	Integrase core domain; Region: rve; pfam00665
1415784000476	Integrase core domain; Region: rve_2; pfam13333
1415784000477	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1415784000478	Helix-turn-helix domain; Region: HTH_28; pfam13518
1415784000479	Helix-turn-helix domain; Region: HTH_28; pfam13518
1415784000480	Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503
1415784000481	Predicted membrane protein [Function unknown]; Region: COG2311
1415784000482	Protein of unknown function (DUF418); Region: DUF418; cl12135
1415784000483	Protein of unknown function (DUF418); Region: DUF418; pfam04235
1415784000484	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1415784000485	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1415784000486	Coenzyme A binding pocket [chemical binding]; other site
1415784000487	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
1415784000488	metal-dependent hydrolase; Provisional; Region: PRK13291
1415784000489	DinB superfamily; Region: DinB_2; pfam12867
1415784000490	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
1415784000491	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784000492	Coenzyme A binding pocket [chemical binding]; other site
1415784000493	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1415784000494	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1415784000495	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1415784000496	active site
1415784000497	NTP binding site [chemical binding]; other site
1415784000498	metal binding triad [ion binding]; metal-binding site
1415784000499	antibiotic binding site [chemical binding]; other site
1415784000500	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
1415784000501	A new structural DNA glycosylase; Region: AlkD_like; cd06561
1415784000502	active site
1415784000503	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1415784000504	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
1415784000505	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1415784000506	catalytic residue [active]
1415784000507	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1415784000508	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1415784000509	active site
1415784000510	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1415784000511	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1415784000512	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
1415784000513	conserved cys residue [active]
1415784000514	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1415784000515	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
1415784000516	NodB motif; other site
1415784000517	active site
1415784000518	catalytic site [active]
1415784000519	Zn binding site [ion binding]; other site
1415784000520	hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841
1415784000521	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1415784000522	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1415784000523	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
1415784000524	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1415784000525	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784000526	putative substrate translocation pore; other site
1415784000527	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784000528	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
1415784000529	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1415784000530	Sulfatase; Region: Sulfatase; pfam00884
1415784000531	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
1415784000532	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1415784000533	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1415784000534	ABC transporter; Region: ABC_tran_2; pfam12848
1415784000535	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1415784000536	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1415784000537	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1415784000538	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1415784000539	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1415784000540	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1415784000541	nudix motif; other site
1415784000542	Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552
1415784000543	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784000544	Coenzyme A binding pocket [chemical binding]; other site
1415784000545	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1415784000546	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1415784000547	hinge; other site
1415784000548	active site
1415784000549	prephenate dehydrogenase; Validated; Region: PRK06545
1415784000550	prephenate dehydrogenase; Validated; Region: PRK08507
1415784000551	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
1415784000552	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
1415784000553	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1415784000554	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784000555	homodimer interface [polypeptide binding]; other site
1415784000556	catalytic residue [active]
1415784000557	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1415784000558	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1415784000559	Tetramer interface [polypeptide binding]; other site
1415784000560	active site
1415784000561	FMN-binding site [chemical binding]; other site
1415784000562	bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595
1415784000563	Chorismate mutase type II; Region: CM_2; cl00693
1415784000564	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
1415784000565	Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406
1415784000566	Domain of unknown function (DUF4020); Region: DUF4020; pfam13212
1415784000567	Protein of unknown function (DUF2512); Region: DUF2512; pfam10710
1415784000568	Isochorismatase family; Region: Isochorismatase; pfam00857
1415784000569	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
1415784000570	catalytic triad [active]
1415784000571	conserved cis-peptide bond; other site
1415784000572	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1415784000573	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784000574	Coenzyme A binding pocket [chemical binding]; other site
1415784000575	hypothetical protein; Provisional; Region: PRK06762
1415784000576	Shikimate kinase; Region: SKI; pfam01202
1415784000577	UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721
1415784000578	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
1415784000579	Bacterial SH3 domain; Region: SH3_3; pfam08239
1415784000580	Bacterial SH3 domain; Region: SH3_3; pfam08239
1415784000581	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
1415784000582	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241
1415784000583	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1415784000584	putative metal binding site [ion binding]; other site
1415784000585	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1415784000586	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784000587	Coenzyme A binding pocket [chemical binding]; other site
1415784000588	Predicted flavoprotein [General function prediction only]; Region: COG0431
1415784000589	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1415784000590	DinB superfamily; Region: DinB_2; pfam12867
1415784000591	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
1415784000592	Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094
1415784000593	malate:quinone oxidoreductase; Validated; Region: PRK05257
1415784000594	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
1415784000595	autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408
1415784000596	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
1415784000597	ligand binding site [chemical binding]; other site
1415784000598	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1415784000599	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1415784000600	TM-ABC transporter signature motif; other site
1415784000601	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1415784000602	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1415784000603	TM-ABC transporter signature motif; other site
1415784000604	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1415784000605	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1415784000606	Walker A/P-loop; other site
1415784000607	ATP binding site [chemical binding]; other site
1415784000608	Q-loop/lid; other site
1415784000609	ABC transporter signature motif; other site
1415784000610	Walker B; other site
1415784000611	D-loop; other site
1415784000612	H-loop/switch region; other site
1415784000613	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1415784000614	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1415784000615	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1415784000616	autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939
1415784000617	Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775
1415784000618	putative N- and C-terminal domain interface [polypeptide binding]; other site
1415784000619	putative active site [active]
1415784000620	putative MgATP binding site [chemical binding]; other site
1415784000621	catalytic site [active]
1415784000622	metal binding site [ion binding]; metal-binding site
1415784000623	putative carbohydrate binding site [chemical binding]; other site
1415784000624	Cupin domain; Region: Cupin_2; pfam07883
1415784000625	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
1415784000626	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
1415784000627	putative active site; other site
1415784000628	catalytic residue [active]
1415784000629	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1415784000630	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1415784000631	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1415784000632	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1415784000633	active site
1415784000634	metal binding site [ion binding]; metal-binding site
1415784000635	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1415784000636	active site
1415784000637	NTP binding site [chemical binding]; other site
1415784000638	metal binding triad [ion binding]; metal-binding site
1415784000639	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1415784000640	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784000641	H+ Antiporter protein; Region: 2A0121; TIGR00900
1415784000642	putative substrate translocation pore; other site
1415784000643	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1415784000644	dimerization interface [polypeptide binding]; other site
1415784000645	putative DNA binding site [nucleotide binding]; other site
1415784000646	putative Zn2+ binding site [ion binding]; other site
1415784000647	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1415784000648	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1415784000649	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
1415784000650	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
1415784000651	YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094
1415784000652	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
1415784000653	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1415784000654	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1415784000655	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1415784000656	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1415784000657	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1415784000658	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1415784000659	putative catalytic cysteine [active]
1415784000660	gamma-glutamyl kinase; Provisional; Region: PRK05429
1415784000661	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1415784000662	nucleotide binding site [chemical binding]; other site
1415784000663	homotetrameric interface [polypeptide binding]; other site
1415784000664	putative phosphate binding site [ion binding]; other site
1415784000665	putative allosteric binding site; other site
1415784000666	PUA domain; Region: PUA; pfam01472
1415784000667	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1415784000668	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
1415784000669	M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654
1415784000670	putative metal binding site [ion binding]; other site
1415784000671	putative dimer interface [polypeptide binding]; other site
1415784000672	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1415784000673	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1415784000674	Bacterial transcriptional regulator; Region: IclR; pfam01614
1415784000675	S-methylmethionine transporter; Provisional; Region: PRK11387
1415784000676	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1415784000677	active site
1415784000678	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1415784000679	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
1415784000680	putative di-iron ligands [ion binding]; other site
1415784000681	VanW like protein; Region: VanW; pfam04294
1415784000682	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
1415784000683	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
1415784000684	dimer interface [polypeptide binding]; other site
1415784000685	active site
1415784000686	Protein of unknown function (DUF3036); Region: DUF3036; pfam11234
1415784000687	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1415784000688	salt bridge; other site
1415784000689	non-specific DNA binding site [nucleotide binding]; other site
1415784000690	sequence-specific DNA binding site [nucleotide binding]; other site
1415784000691	Protein of unknown function (DUF962); Region: DUF962; cl01879
1415784000692	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1415784000693	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1415784000694	active site
1415784000695	motif I; other site
1415784000696	motif II; other site
1415784000697	uridine kinase; Provisional; Region: PRK07667
1415784000698	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1415784000699	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1415784000700	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1415784000701	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1415784000702	active site
1415784000703	metal binding site [ion binding]; metal-binding site
1415784000704	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
1415784000705	Predicted transcriptional regulators [Transcription]; Region: COG1695
1415784000706	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1415784000707	MoxR-like ATPases [General function prediction only]; Region: COG0714
1415784000708	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1415784000709	Walker A motif; other site
1415784000710	ATP binding site [chemical binding]; other site
1415784000711	Walker B motif; other site
1415784000712	arginine finger; other site
1415784000713	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1415784000714	Protein of unknown function DUF58; Region: DUF58; pfam01882
1415784000715	Domain of unknown function (DUF4018); Region: DUF4018; pfam13210
1415784000716	putative transposase OrfB; Reviewed; Region: PHA02517
1415784000717	HTH-like domain; Region: HTH_21; pfam13276
1415784000718	Integrase core domain; Region: rve; pfam00665
1415784000719	Integrase core domain; Region: rve_2; pfam13333
1415784000720	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1415784000721	Helix-turn-helix domain; Region: HTH_28; pfam13518
1415784000722	Helix-turn-helix domain; Region: HTH_28; pfam13518
1415784000723	proline/glycine betaine transporter; Provisional; Region: PRK10642
1415784000724	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784000725	putative substrate translocation pore; other site
1415784000726	acetylornithine aminotransferase; Provisional; Region: PRK02627
1415784000727	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1415784000728	inhibitor-cofactor binding pocket; inhibition site
1415784000729	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784000730	catalytic residue [active]
1415784000731	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
1415784000732	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1415784000733	heme binding pocket [chemical binding]; other site
1415784000734	Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453
1415784000735	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
1415784000736	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
1415784000737	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
1415784000738	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1415784000739	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
1415784000740	active site
1415784000741	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
1415784000742	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1415784000743	Beta-lactamase; Region: Beta-lactamase; pfam00144
1415784000744	Protein of unknown function (DUF3902); Region: DUF3902; pfam13042
1415784000745	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1415784000746	Protein of unknown function DUF58; Region: DUF58; pfam01882
1415784000747	MoxR-like ATPases [General function prediction only]; Region: COG0714
1415784000748	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1415784000749	Walker A motif; other site
1415784000750	ATP binding site [chemical binding]; other site
1415784000751	Walker B motif; other site
1415784000752	arginine finger; other site
1415784000753	Domain of unknown function (DUF1910); Region: DUF1910; pfam08928
1415784000754	Domain of unknown function (DUF1911); Region: DUF1911; pfam08929
1415784000755	LXG domain of WXG superfamily; Region: LXG; pfam04740
1415784000756	Protein of unknown function (DUF3958); Region: DUF3958; pfam13125
1415784000757	type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197
1415784000758	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1415784000759	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
1415784000760	dimer interface [polypeptide binding]; other site
1415784000761	FMN binding site [chemical binding]; other site
1415784000762	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1415784000763	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1415784000764	putative DNA binding site [nucleotide binding]; other site
1415784000765	putative Zn2+ binding site [ion binding]; other site
1415784000766	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
1415784000767	Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168
1415784000768	G1 box; other site
1415784000769	putative GEF interaction site [polypeptide binding]; other site
1415784000770	GTP/Mg2+ binding site [chemical binding]; other site
1415784000771	Switch I region; other site
1415784000772	G2 box; other site
1415784000773	G3 box; other site
1415784000774	Switch II region; other site
1415784000775	G4 box; other site
1415784000776	G5 box; other site
1415784000777	Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690
1415784000778	EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684
1415784000779	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
1415784000780	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1415784000781	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688
1415784000782	nudix motif; other site
1415784000783	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
1415784000784	Protein of unknown function (DUF4240); Region: DUF4240; pfam14024
1415784000785	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
1415784000786	atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265
1415784000787	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1415784000788	putative NAD(P) binding site [chemical binding]; other site
1415784000789	active site
1415784000790	CAAX protease self-immunity; Region: Abi; pfam02517
1415784000791	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1415784000792	Beta-lactamase; Region: Beta-lactamase; pfam00144
1415784000793	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1415784000794	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1415784000795	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
1415784000796	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784000797	Coenzyme A binding pocket [chemical binding]; other site
1415784000798	Domain of unknown function (DUF3980); Region: DUF3980; pfam13140
1415784000799	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
1415784000800	nudix motif; other site
1415784000801	EamA-like transporter family; Region: EamA; pfam00892
1415784000802	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1415784000803	EamA-like transporter family; Region: EamA; pfam00892
1415784000804	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1415784000805	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1415784000806	DNA-binding site [nucleotide binding]; DNA binding site
1415784000807	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1415784000808	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784000809	homodimer interface [polypeptide binding]; other site
1415784000810	catalytic residue [active]
1415784000811	hypothetical protein; Validated; Region: PRK00124
1415784000812	Protein of unknown function (DUF3892); Region: DUF3892; pfam13031
1415784000813	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1415784000814	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1415784000815	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1415784000816	phosphorylation site [posttranslational modification]
1415784000817	dimer interface [polypeptide binding]; other site
1415784000818	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784000819	ATP binding site [chemical binding]; other site
1415784000820	Mg2+ binding site [ion binding]; other site
1415784000821	G-X-G motif; other site
1415784000822	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1415784000823	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784000824	active site
1415784000825	phosphorylation site [posttranslational modification]
1415784000826	intermolecular recognition site; other site
1415784000827	dimerization interface [polypeptide binding]; other site
1415784000828	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
1415784000829	DNA binding site [nucleotide binding]
1415784000830	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1415784000831	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1415784000832	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
1415784000833	uridine kinase; Validated; Region: PRK06696
1415784000834	active site
1415784000835	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1415784000836	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
1415784000837	active site
1415784000838	metal binding site [ion binding]; metal-binding site
1415784000839	Phosphotransferase enzyme family; Region: APH; pfam01636
1415784000840	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1415784000841	active site
1415784000842	ATP binding site [chemical binding]; other site
1415784000843	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
1415784000844	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1415784000845	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1415784000846	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1415784000847	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1415784000848	Coenzyme A binding pocket [chemical binding]; other site
1415784000849	lysine transporter; Provisional; Region: PRK10836
1415784000850	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
1415784000851	Protein of unknown function (DUF2716); Region: DUF2716; pfam10898
1415784000852	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
1415784000853	Methyltransferase domain; Region: Methyltransf_11; pfam08241
1415784000854	S-adenosylmethionine binding site [chemical binding]; other site
1415784000855	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
1415784000856	putative active site [active]
1415784000857	nucleotide binding site [chemical binding]; other site
1415784000858	nudix motif; other site
1415784000859	putative metal binding site [ion binding]; other site
1415784000860	Cephalosporin hydroxylase; Region: CmcI; pfam04989
1415784000861	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1415784000862	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1415784000863	Catalytic site [active]
1415784000864	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1415784000865	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1415784000866	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1415784000867	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1415784000868	NAD-dependent deacetylase; Provisional; Region: PRK00481
1415784000869	SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413
1415784000870	NAD+ binding site [chemical binding]; other site
1415784000871	substrate binding site [chemical binding]; other site
1415784000872	Zn binding site [ion binding]; other site
1415784000873	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
1415784000874	putative substrate binding pocket [chemical binding]; other site
1415784000875	AC domain interface; other site
1415784000876	catalytic triad [active]
1415784000877	AB domain interface; other site
1415784000878	interchain disulfide; other site
1415784000879	Predicted membrane protein [Function unknown]; Region: COG3817
1415784000880	Protein of unknown function (DUF979); Region: DUF979; pfam06166
1415784000881	Protein of unknown function (DUF969); Region: DUF969; pfam06149
1415784000882	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
1415784000883	putative active site [active]
1415784000884	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
1415784000885	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
1415784000886	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
1415784000887	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1415784000888	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1415784000889	Bacterial transcriptional regulator; Region: IclR; pfam01614
1415784000890	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
1415784000891	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1415784000892	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1415784000893	Catalytic site [active]
1415784000894	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
1415784000895	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353
1415784000896	putative dimer interface [polypeptide binding]; other site
1415784000897	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1415784000898	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1415784000899	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1415784000900	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1415784000901	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1415784000902	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1415784000903	putative active site [active]
1415784000904	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1415784000905	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1415784000906	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
1415784000907	Nucleoside recognition; Region: Gate; pfam07670
1415784000908	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1415784000909	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1415784000910	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1415784000911	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1415784000912	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1415784000913	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1415784000914	Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155
1415784000915	Phosphotransferase enzyme family; Region: APH; pfam01636
1415784000916	putative active site [active]
1415784000917	putative substrate binding site [chemical binding]; other site
1415784000918	ATP binding site [chemical binding]; other site
1415784000919	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784000920	Coenzyme A binding pocket [chemical binding]; other site
1415784000921	Protein of unknown function (DUF2691); Region: DUF2691; pfam10903
1415784000922	Uncharacterized conserved protein [Function unknown]; Region: COG1633
1415784000923	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
1415784000924	dinuclear metal binding motif [ion binding]; other site
1415784000925	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1415784000926	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1415784000927	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1415784000928	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1415784000929	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
1415784000930	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412
1415784000931	Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547
1415784000932	phosphoenolpyruvate synthase; Validated; Region: PRK06241
1415784000933	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1415784000934	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1415784000935	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1415784000936	heme-binding site [chemical binding]; other site
1415784000937	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1415784000938	Leucine rich repeat; Region: LRR_8; pfam13855
1415784000939	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
1415784000940	Leucine-rich repeats; other site
1415784000941	Substrate binding site [chemical binding]; other site
1415784000942	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1415784000943	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1415784000944	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1415784000945	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1415784000946	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1415784000947	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1415784000948	LRR adjacent; Region: LRR_adjacent; pfam08191
1415784000949	YolD-like protein; Region: YolD; pfam08863
1415784000950	DNA polymerase IV; Reviewed; Region: PRK03103
1415784000951	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
1415784000952	active site
1415784000953	DNA binding site [nucleotide binding]
1415784000954	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
1415784000955	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
1415784000956	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1415784000957	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1415784000958	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
1415784000959	putative active site [active]
1415784000960	putative metal binding site [ion binding]; other site
1415784000961	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1415784000962	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1415784000963	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1415784000964	TAP-like protein; Region: Abhydrolase_4; pfam08386
1415784000965	Isochorismatase family; Region: Isochorismatase; pfam00857
1415784000966	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
1415784000967	catalytic triad [active]
1415784000968	dimer interface [polypeptide binding]; other site
1415784000969	conserved cis-peptide bond; other site
1415784000970	Isochorismatase family; Region: Isochorismatase; pfam00857
1415784000971	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
1415784000972	catalytic triad [active]
1415784000973	dimer interface [polypeptide binding]; other site
1415784000974	conserved cis-peptide bond; other site
1415784000975	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
1415784000976	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1415784000977	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1415784000978	active site
1415784000979	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1415784000980	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1415784000981	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1415784000982	dimerization interface [polypeptide binding]; other site
1415784000983	MarR family; Region: MarR; pfam01047
1415784000984	Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821
1415784000985	Cl binding site [ion binding]; other site
1415784000986	oligomer interface [polypeptide binding]; other site
1415784000987	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
1415784000988	plasmid segregation protein ParM; Provisional; Region: PRK13917
1415784000989	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
1415784000990	Mg binding site [ion binding]; other site
1415784000991	nucleotide binding site [chemical binding]; other site
1415784000992	putative protofilament interface [polypeptide binding]; other site
1415784000993	Heat induced stress protein YflT; Region: YflT; pfam11181
1415784000994	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
1415784000995	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1415784000996	TspO/MBR family; Region: TspO_MBR; pfam03073
1415784000997	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
1415784000998	DNA photolyase; Region: DNA_photolyase; pfam00875
1415784000999	Adenoviral protein L1 52/55-kDa; Region: Adeno_52K; pfam03052
1415784001000	Carbonic anhydrase; Region: Pro_CA; pfam00484
1415784001001	zinc binding site [ion binding]; other site
1415784001002	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
1415784001003	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
1415784001004	NADH dehydrogenase subunit 5; Validated; Region: PRK08601
1415784001005	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1415784001006	Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057
1415784001007	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1415784001008	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784001009	putative substrate translocation pore; other site
1415784001010	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1415784001011	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1415784001012	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1415784001013	dimerization interface [polypeptide binding]; other site
1415784001014	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1415784001015	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1415784001016	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1415784001017	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1415784001018	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1415784001019	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
1415784001020	NodB motif; other site
1415784001021	active site
1415784001022	catalytic site [active]
1415784001023	Zn binding site [ion binding]; other site
1415784001024	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1415784001025	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1415784001026	active site
1415784001027	metal binding site [ion binding]; metal-binding site
1415784001028	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1415784001029	dimer interface [polypeptide binding]; other site
1415784001030	phosphorylation site [posttranslational modification]
1415784001031	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784001032	ATP binding site [chemical binding]; other site
1415784001033	Mg2+ binding site [ion binding]; other site
1415784001034	G-X-G motif; other site
1415784001035	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1415784001036	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784001037	active site
1415784001038	phosphorylation site [posttranslational modification]
1415784001039	intermolecular recognition site; other site
1415784001040	dimerization interface [polypeptide binding]; other site
1415784001041	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1415784001042	DNA binding site [nucleotide binding]
1415784001043	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1415784001044	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784001045	Coenzyme A binding pocket [chemical binding]; other site
1415784001046	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387
1415784001047	UbiA prenyltransferase family; Region: UbiA; pfam01040
1415784001048	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1415784001049	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
1415784001050	metal binding site [ion binding]; metal-binding site
1415784001051	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1415784001052	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1415784001053	dimer interface [polypeptide binding]; other site
1415784001054	ABC-ATPase subunit  interface; other site
1415784001055	putative PBP binding regions; other site
1415784001056	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1415784001057	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1415784001058	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1415784001059	dimerization interface [polypeptide binding]; other site
1415784001060	putative Zn2+ binding site [ion binding]; other site
1415784001061	putative DNA binding site [nucleotide binding]; other site
1415784001062	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1415784001063	metal-binding site [ion binding]
1415784001064	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
1415784001065	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1415784001066	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1415784001067	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
1415784001068	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
1415784001069	Cu(I) binding site [ion binding]; other site
1415784001070	Thioredoxin; Region: Thioredoxin_4; pfam13462
1415784001071	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1415784001072	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
1415784001073	Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798
1415784001074	Phosphotransferase enzyme family; Region: APH; pfam01636
1415784001075	GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746
1415784001076	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1415784001077	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1415784001078	active site
1415784001079	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
1415784001080	arsenical-resistance protein; Region: acr3; TIGR00832
1415784001081	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1415784001082	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
1415784001083	putative metal binding site [ion binding]; other site
1415784001084	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1415784001085	putative DNA binding site [nucleotide binding]; other site
1415784001086	DinB superfamily; Region: DinB_2; pfam12867
1415784001087	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
1415784001088	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
1415784001089	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
1415784001090	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1415784001091	MarR family; Region: MarR_2; pfam12802
1415784001092	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
1415784001093	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1415784001094	putative NAD(P) binding site [chemical binding]; other site
1415784001095	active site
1415784001096	putative substrate binding site [chemical binding]; other site
1415784001097	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1415784001098	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1415784001099	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1415784001100	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1415784001101	DNA-binding site [nucleotide binding]; DNA binding site
1415784001102	fatty acid metabolism transcriptional regulator FadR; Region: fadR_gamma; TIGR02812
1415784001103	FadR C-terminal domain; Region: FadR_C; pfam07840
1415784001104	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
1415784001105	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1415784001106	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1415784001107	Spore germination protein; Region: Spore_permease; cl17796
1415784001108	Helix-turn-helix domain; Region: HTH_28; pfam13518
1415784001109	putative transposase OrfB; Reviewed; Region: PHA02517
1415784001110	HTH-like domain; Region: HTH_21; pfam13276
1415784001111	Integrase core domain; Region: rve; pfam00665
1415784001112	Integrase core domain; Region: rve_3; pfam13683
1415784001113	Spore germination protein; Region: Spore_permease; cl17796
1415784001114	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1415784001115	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1415784001116	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784001117	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1415784001118	short chain dehydrogenase; Provisional; Region: PRK12746
1415784001119	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
1415784001120	NADP binding site [chemical binding]; other site
1415784001121	homodimer interface [polypeptide binding]; other site
1415784001122	active site
1415784001123	substrate binding site [chemical binding]; other site
1415784001124	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1415784001125	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1415784001126	putative DNA binding site [nucleotide binding]; other site
1415784001127	putative Zn2+ binding site [ion binding]; other site
1415784001128	AsnC family; Region: AsnC_trans_reg; pfam01037
1415784001129	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
1415784001130	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1415784001131	metal binding site [ion binding]; metal-binding site
1415784001132	AAA domain; Region: AAA_11; pfam13086
1415784001133	Part of AAA domain; Region: AAA_19; pfam13245
1415784001134	Erp protein C-terminus; Region: Erp_C; pfam06780
1415784001135	AAA domain; Region: AAA_30; pfam13604
1415784001136	AAA domain; Region: AAA_12; pfam13087
1415784001137	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1415784001138	putative active site [active]
1415784001139	catalytic site [active]
1415784001140	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1415784001141	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1415784001142	active site
1415784001143	metal binding site [ion binding]; metal-binding site
1415784001144	putative monooxygenase; Provisional; Region: PRK11118
1415784001145	DoxX-like family; Region: DoxX_2; pfam13564
1415784001146	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1415784001147	MarR family; Region: MarR_2; pfam12802
1415784001148	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
1415784001149	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
1415784001150	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
1415784001151	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
1415784001152	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1415784001153	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1415784001154	Cytochrome P450; Region: p450; pfam00067
1415784001155	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
1415784001156	Flavodoxin; Region: Flavodoxin_1; pfam00258
1415784001157	These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206
1415784001158	FAD binding pocket [chemical binding]; other site
1415784001159	FAD binding motif [chemical binding]; other site
1415784001160	catalytic residues [active]
1415784001161	NAD binding pocket [chemical binding]; other site
1415784001162	phosphate binding motif [ion binding]; other site
1415784001163	beta-alpha-beta structure motif; other site
1415784001164	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
1415784001165	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1415784001166	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1415784001167	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784001168	putative substrate translocation pore; other site
1415784001169	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784001170	D-cysteine desulfhydrase; Validated; Region: PRK03910
1415784001171	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
1415784001172	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1415784001173	catalytic residue [active]
1415784001174	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1415784001175	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1415784001176	active site
1415784001177	metal binding site [ion binding]; metal-binding site
1415784001178	Domain of unknown function (DUF4073); Region: DUF4073; pfam13285
1415784001179	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1415784001180	Beta-lactamase; Region: Beta-lactamase; pfam00144
1415784001181	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1415784001182	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
1415784001183	hypothetical protein; Provisional; Region: PRK06762
1415784001184	AAA domain; Region: AAA_33; pfam13671
1415784001185	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
1415784001186	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1415784001187	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1415784001188	Walker A/P-loop; other site
1415784001189	ATP binding site [chemical binding]; other site
1415784001190	Q-loop/lid; other site
1415784001191	ABC transporter signature motif; other site
1415784001192	Walker B; other site
1415784001193	D-loop; other site
1415784001194	H-loop/switch region; other site
1415784001195	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1415784001196	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1415784001197	FtsX-like permease family; Region: FtsX; pfam02687
1415784001198	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1415784001199	dimerization interface [polypeptide binding]; other site
1415784001200	putative DNA binding site [nucleotide binding]; other site
1415784001201	Predicted transcriptional regulator [Transcription]; Region: COG2345
1415784001202	putative Zn2+ binding site [ion binding]; other site
1415784001203	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784001204	H+ Antiporter protein; Region: 2A0121; TIGR00900
1415784001205	putative substrate translocation pore; other site
1415784001206	DinB superfamily; Region: DinB_2; pfam12867
1415784001207	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1415784001208	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1415784001209	dimerization interface [polypeptide binding]; other site
1415784001210	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1415784001211	dimer interface [polypeptide binding]; other site
1415784001212	phosphorylation site [posttranslational modification]
1415784001213	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784001214	ATP binding site [chemical binding]; other site
1415784001215	Mg2+ binding site [ion binding]; other site
1415784001216	G-X-G motif; other site
1415784001217	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1415784001218	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784001219	active site
1415784001220	phosphorylation site [posttranslational modification]
1415784001221	intermolecular recognition site; other site
1415784001222	dimerization interface [polypeptide binding]; other site
1415784001223	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1415784001224	DNA binding site [nucleotide binding]
1415784001225	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1415784001226	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1415784001227	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1415784001228	2TM domain; Region: 2TM; pfam13239
1415784001229	F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763
1415784001230	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
1415784001231	putative dimer interface [polypeptide binding]; other site
1415784001232	catalytic triad [active]
1415784001233	Protein of unknown function (DUF3224); Region: DUF3224; pfam11528
1415784001234	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
1415784001235	dimer interaction site [polypeptide binding]; other site
1415784001236	substrate-binding tunnel; other site
1415784001237	active site
1415784001238	catalytic site [active]
1415784001239	substrate binding site [chemical binding]; other site
1415784001240	Uncharacterized conserved protein [Function unknown]; Region: COG4198
1415784001241	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
1415784001242	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
1415784001243	putative ligand binding site [chemical binding]; other site
1415784001244	putative NAD binding site [chemical binding]; other site
1415784001245	putative catalytic site [active]
1415784001246	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
1415784001247	L-serine binding site [chemical binding]; other site
1415784001248	ACT domain interface; other site
1415784001249	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
1415784001250	homodimer interface [polypeptide binding]; other site
1415784001251	substrate-cofactor binding pocket; other site
1415784001252	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784001253	catalytic residue [active]
1415784001254	Domain of unknown function (DUF378); Region: DUF378; cl00943
1415784001255	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
1415784001256	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
1415784001257	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
1415784001258	active site
1415784001259	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1415784001260	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1415784001261	active site
1415784001262	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
1415784001263	A new structural DNA glycosylase; Region: AlkD_like; cd06561
1415784001264	active site
1415784001265	Protein of unknown function (DUF3895); Region: DUF3895; pfam13034
1415784001266	A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414
1415784001267	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
1415784001268	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
1415784001269	DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639
1415784001270	GAD-like domain; Region: GAD-like; pfam08887
1415784001271	Domain of unknown function (DUF1851); Region: DUF1851; pfam08906
1415784001272	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
1415784001273	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1415784001274	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
1415784001275	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
1415784001276	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
1415784001277	putative active site [active]
1415784001278	putative metal binding site [ion binding]; other site
1415784001279	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1415784001280	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1415784001281	active site
1415784001282	aminotransferase; Validated; Region: PRK07678
1415784001283	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1415784001284	inhibitor-cofactor binding pocket; inhibition site
1415784001285	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784001286	catalytic residue [active]
1415784001287	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1415784001288	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
1415784001289	tetrameric interface [polypeptide binding]; other site
1415784001290	NAD binding site [chemical binding]; other site
1415784001291	catalytic residues [active]
1415784001292	Protein of unknown function (DUF861); Region: Cupin_3; pfam05899
1415784001293	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1415784001294	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
1415784001295	Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119
1415784001296	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1415784001297	tetramerization interface [polypeptide binding]; other site
1415784001298	NAD(P) binding site [chemical binding]; other site
1415784001299	catalytic residues [active]
1415784001300	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1415784001301	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1415784001302	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg1; cd04777
1415784001303	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1415784001304	DNA binding residues [nucleotide binding]
1415784001305	putative dimer interface [polypeptide binding]; other site
1415784001306	NETI protein; Region: NETI; pfam14044
1415784001307	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784001308	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1415784001309	putative substrate translocation pore; other site
1415784001310	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1415784001311	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1415784001312	TAP-like protein; Region: Abhydrolase_4; pfam08386
1415784001313	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1415784001314	MarR family; Region: MarR_2; pfam12802
1415784001315	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1415784001316	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784001317	putative substrate translocation pore; other site
1415784001318	YwiC-like protein; Region: YwiC; pfam14256
1415784001319	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
1415784001320	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1415784001321	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1415784001322	Walker A/P-loop; other site
1415784001323	ATP binding site [chemical binding]; other site
1415784001324	Q-loop/lid; other site
1415784001325	ABC transporter signature motif; other site
1415784001326	Walker B; other site
1415784001327	D-loop; other site
1415784001328	H-loop/switch region; other site
1415784001329	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1415784001330	Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226
1415784001331	Walker A/P-loop; other site
1415784001332	ATP binding site [chemical binding]; other site
1415784001333	Q-loop/lid; other site
1415784001334	ABC transporter signature motif; other site
1415784001335	Walker B; other site
1415784001336	D-loop; other site
1415784001337	H-loop/switch region; other site
1415784001338	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1415784001339	Calreticulin family; Region: Calreticulin; pfam00262
1415784001340	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
1415784001341	Prenyltransferase-like; Region: Prenyltrans_1; pfam13243
1415784001342	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
1415784001343	Predicted membrane protein [Function unknown]; Region: COG1288; cl17886
1415784001344	Predicted membrane protein [Function unknown]; Region: COG1288; cl17886
1415784001345	Endonuclease I; Region: Endonuclease_1; pfam04231
1415784001346	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
1415784001347	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
1415784001348	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
1415784001349	putative deacylase active site [active]
1415784001350	histidyl-tRNA synthetase; Provisional; Region: PRK12420
1415784001351	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1415784001352	dimer interface [polypeptide binding]; other site
1415784001353	motif 1; other site
1415784001354	active site
1415784001355	motif 2; other site
1415784001356	motif 3; other site
1415784001357	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1415784001358	anticodon binding site; other site
1415784001359	Predicted transcriptional regulators [Transcription]; Region: COG1733
1415784001360	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1415784001361	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
1415784001362	dimer interface [polypeptide binding]; other site
1415784001363	FMN binding site [chemical binding]; other site
1415784001364	pyruvate kinase; Validated; Region: PRK06739
1415784001365	active site
1415784001366	domain interfaces; other site
1415784001367	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748
1415784001368	classical (c) SDRs; Region: SDR_c; cd05233
1415784001369	NAD(P) binding site [chemical binding]; other site
1415784001370	active site
1415784001371	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1415784001372	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1415784001373	Walker A/P-loop; other site
1415784001374	ATP binding site [chemical binding]; other site
1415784001375	Q-loop/lid; other site
1415784001376	ABC transporter signature motif; other site
1415784001377	Walker B; other site
1415784001378	D-loop; other site
1415784001379	H-loop/switch region; other site
1415784001380	Protein of unknown function (DUF3796); Region: DUF3796; pfam12676
1415784001381	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1415784001382	non-specific DNA binding site [nucleotide binding]; other site
1415784001383	salt bridge; other site
1415784001384	sequence-specific DNA binding site [nucleotide binding]; other site
1415784001385	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
1415784001386	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1415784001387	motif II; other site
1415784001388	Phosphotransferase enzyme family; Region: APH; pfam01636
1415784001389	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1415784001390	active site
1415784001391	substrate binding site [chemical binding]; other site
1415784001392	ATP binding site [chemical binding]; other site
1415784001393	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
1415784001394	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
1415784001395	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
1415784001396	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
1415784001397	nudix motif; other site
1415784001398	Protein of unknown function (DUF2651); Region: DUF2651; pfam10852
1415784001399	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241
1415784001400	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1415784001401	putative metal binding site [ion binding]; other site
1415784001402	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1415784001403	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1415784001404	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784001405	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1415784001406	maltose O-acetyltransferase; Provisional; Region: PRK10092
1415784001407	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1415784001408	active site
1415784001409	substrate binding site [chemical binding]; other site
1415784001410	trimer interface [polypeptide binding]; other site
1415784001411	CoA binding site [chemical binding]; other site
1415784001412	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1415784001413	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1415784001414	active site
1415784001415	HIGH motif; other site
1415784001416	dimer interface [polypeptide binding]; other site
1415784001417	KMSKS motif; other site
1415784001418	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK12464
1415784001419	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1415784001420	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1415784001421	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1415784001422	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1415784001423	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1415784001424	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784001425	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1415784001426	Coenzyme A binding pocket [chemical binding]; other site
1415784001427	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784001428	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1415784001429	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
1415784001430	CGNR zinc finger; Region: zf-CGNR; pfam11706
1415784001431	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784001432	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1415784001433	putative substrate translocation pore; other site
1415784001434	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1415784001435	binding surface
1415784001436	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1415784001437	TPR motif; other site
1415784001438	Protein of unknown function (DUF3923); Region: DUF3923; pfam13061
1415784001439	hypothetical protein; Provisional; Region: PRK04164
1415784001440	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1415784001441	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1415784001442	Domain of unknown function DUF21; Region: DUF21; pfam01595
1415784001443	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1415784001444	Transporter associated domain; Region: CorC_HlyC; smart01091
1415784001445	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779
1415784001446	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1415784001447	DNA binding residues [nucleotide binding]
1415784001448	putative dimer interface [polypeptide binding]; other site
1415784001449	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
1415784001450	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1415784001451	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
1415784001452	substrate binding site; other site
1415784001453	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
1415784001454	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1415784001455	NAD(P) binding site [chemical binding]; other site
1415784001456	active site
1415784001457	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
1415784001458	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1415784001459	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784001460	S-adenosylmethionine binding site [chemical binding]; other site
1415784001461	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
1415784001462	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1415784001463	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1415784001464	NAD(P) binding site [chemical binding]; other site
1415784001465	active site
1415784001466	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
1415784001467	EamA-like transporter family; Region: EamA; pfam00892
1415784001468	EamA-like transporter family; Region: EamA; pfam00892
1415784001469	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1415784001470	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1415784001471	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813
1415784001472	Protein of unknown function (DUF1272); Region: DUF1272; pfam06906
1415784001473	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
1415784001474	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
1415784001475	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
1415784001476	N- and C-terminal domain interface [polypeptide binding]; other site
1415784001477	active site
1415784001478	catalytic site [active]
1415784001479	metal binding site [ion binding]; metal-binding site
1415784001480	carbohydrate binding site [chemical binding]; other site
1415784001481	ATP binding site [chemical binding]; other site
1415784001482	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1415784001483	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1415784001484	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
1415784001485	active site
1415784001486	intersubunit interactions; other site
1415784001487	catalytic residue [active]
1415784001488	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
1415784001489	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1415784001490	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1415784001491	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1415784001492	TPP-binding site [chemical binding]; other site
1415784001493	dimer interface [polypeptide binding]; other site
1415784001494	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1415784001495	PYR/PP interface [polypeptide binding]; other site
1415784001496	dimer interface [polypeptide binding]; other site
1415784001497	TPP binding site [chemical binding]; other site
1415784001498	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1415784001499	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1415784001500	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1415784001501	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1415784001502	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1415784001503	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
1415784001504	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1415784001505	putative NAD(P) binding site [chemical binding]; other site
1415784001506	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1415784001507	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
1415784001508	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
1415784001509	active site
1415784001510	Zn binding site [ion binding]; other site
1415784001511	Viral enhancin protein; Region: Enhancin; pfam03272
1415784001512	Peptidase M60-like family; Region: M60-like; pfam13402
1415784001513	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
1415784001514	dimer interface [polypeptide binding]; other site
1415784001515	FMN binding site [chemical binding]; other site
1415784001516	hypothetical protein; Provisional; Region: PRK02487
1415784001517	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
1415784001518	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1415784001519	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
1415784001520	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1415784001521	salt bridge; other site
1415784001522	non-specific DNA binding site [nucleotide binding]; other site
1415784001523	sequence-specific DNA binding site [nucleotide binding]; other site
1415784001524	Protein of unknown function (DUF3036); Region: DUF3036; pfam11234
1415784001525	IDEAL domain; Region: IDEAL; pfam08858
1415784001526	Transcriptional regulator; Region: Rrf2; pfam02082
1415784001527	Rrf2 family protein; Region: rrf2_super; TIGR00738
1415784001528	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
1415784001529	ArsC family; Region: ArsC; pfam03960
1415784001530	putative catalytic residues [active]
1415784001531	thiol/disulfide switch; other site
1415784001532	Predicted transcriptional regulators [Transcription]; Region: COG1733
1415784001533	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1415784001534	dimerization interface [polypeptide binding]; other site
1415784001535	putative DNA binding site [nucleotide binding]; other site
1415784001536	putative Zn2+ binding site [ion binding]; other site
1415784001537	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1415784001538	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1415784001539	DNA-binding site [nucleotide binding]; DNA binding site
1415784001540	UTRA domain; Region: UTRA; pfam07702
1415784001541	putative oxidoreductase; Provisional; Region: PRK10206
1415784001542	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1415784001543	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1415784001544	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1415784001545	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1415784001546	active site
1415784001547	catalytic tetrad [active]
1415784001548	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
1415784001549	putative hydrophobic ligand binding site [chemical binding]; other site
1415784001550	protein interface [polypeptide binding]; other site
1415784001551	gate; other site
1415784001552	Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash.  The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838
1415784001553	catalytic triad [active]
1415784001554	oxyanion hole [active]
1415784001555	active site
1415784001556	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1415784001557	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1415784001558	active site
1415784001559	ATP binding site [chemical binding]; other site
1415784001560	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1415784001561	Phosphotransferase enzyme family; Region: APH; pfam01636
1415784001562	substrate binding site [chemical binding]; other site
1415784001563	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1415784001564	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1415784001565	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784001566	Coenzyme A binding pocket [chemical binding]; other site
1415784001567	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1415784001568	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1415784001569	acyl-activating enzyme (AAE) consensus motif; other site
1415784001570	AMP binding site [chemical binding]; other site
1415784001571	active site
1415784001572	CoA binding site [chemical binding]; other site
1415784001573	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
1415784001574	Predicted transcriptional regulators [Transcription]; Region: COG1733
1415784001575	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1415784001576	dimerization interface [polypeptide binding]; other site
1415784001577	putative DNA binding site [nucleotide binding]; other site
1415784001578	putative Zn2+ binding site [ion binding]; other site
1415784001579	CrcB-like protein; Region: CRCB; cl09114
1415784001580	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
1415784001581	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1415784001582	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1415784001583	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1415784001584	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1415784001585	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1415784001586	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1415784001587	dimerization interface [polypeptide binding]; other site
1415784001588	putative DNA binding site [nucleotide binding]; other site
1415784001589	putative Zn2+ binding site [ion binding]; other site
1415784001590	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
1415784001591	active site
1415784001592	Glyco_18 domain; Region: Glyco_18; smart00636
1415784001593	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
1415784001594	Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962
1415784001595	NodB motif; other site
1415784001596	putative active site [active]
1415784001597	putative catalytic site [active]
1415784001598	putative Zn binding site [ion binding]; other site
1415784001599	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
1415784001600	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1415784001601	DXD motif; other site
1415784001602	Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791
1415784001603	putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311
1415784001604	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1415784001605	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1415784001606	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
1415784001607	active site
1415784001608	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1415784001609	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
1415784001610	HTH domain; Region: HTH_11; pfam08279
1415784001611	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1415784001612	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1415784001613	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1415784001614	Walker A/P-loop; other site
1415784001615	ATP binding site [chemical binding]; other site
1415784001616	Q-loop/lid; other site
1415784001617	ABC transporter signature motif; other site
1415784001618	Walker B; other site
1415784001619	D-loop; other site
1415784001620	H-loop/switch region; other site
1415784001621	Protein of unknown function (DUF1048); Region: DUF1048; pfam06304
1415784001622	Predicted transcriptional regulators [Transcription]; Region: COG1695
1415784001623	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1415784001624	hydroxylamine reductase; Provisional; Region: PRK12310
1415784001625	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1415784001626	ACS interaction site; other site
1415784001627	CODH interaction site; other site
1415784001628	metal cluster binding site [ion binding]; other site
1415784001629	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1415784001630	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413
1415784001631	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
1415784001632	active site
1415784001633	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
1415784001634	metal binding site [ion binding]; metal-binding site
1415784001635	Domain of unknown function (DUF3784); Region: DUF3784; pfam12650
1415784001636	hypothetical protein; Provisional; Region: PRK06771
1415784001637	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1415784001638	Beta-lactamase; Region: Beta-lactamase; pfam00144
1415784001639	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1415784001640	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1415784001641	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
1415784001642	dimer interface [polypeptide binding]; other site
1415784001643	ligand binding site [chemical binding]; other site
1415784001644	DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402
1415784001645	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1415784001646	ligand binding site [chemical binding]; other site
1415784001647	flexible hinge region; other site
1415784001648	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
1415784001649	Protein of unknown function, DUF606; Region: DUF606; pfam04657
1415784001650	Protein of unknown function, DUF606; Region: DUF606; pfam04657
1415784001651	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1415784001652	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
1415784001653	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
1415784001654	putative NAD(P) binding site [chemical binding]; other site
1415784001655	dimer interface [polypeptide binding]; other site
1415784001656	putative transport protein YifK; Provisional; Region: PRK10746
1415784001657	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
1415784001658	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784001659	Coenzyme A binding pocket [chemical binding]; other site
1415784001660	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784001661	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
1415784001662	putative substrate translocation pore; other site
1415784001663	Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908
1415784001664	DinB superfamily; Region: DinB_2; pfam12867
1415784001665	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
1415784001666	Haemolysin XhlA; Region: XhlA; pfam10779
1415784001667	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
1415784001668	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1415784001669	NAD(P) binding site [chemical binding]; other site
1415784001670	active site
1415784001671	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
1415784001672	Protein of unknown function (DUF1806); Region: DUF1806; pfam08830
1415784001673	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
1415784001674	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
1415784001675	transmembrane helices; other site
1415784001676	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1415784001677	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1415784001678	Coenzyme A binding pocket [chemical binding]; other site
1415784001679	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1415784001680	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
1415784001681	putative ligand binding residues [chemical binding]; other site
1415784001682	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1415784001683	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1415784001684	ABC-ATPase subunit  interface; other site
1415784001685	dimer interface [polypeptide binding]; other site
1415784001686	putative PBP binding regions; other site
1415784001687	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1415784001688	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1415784001689	ABC-ATPase subunit  interface; other site
1415784001690	dimer interface [polypeptide binding]; other site
1415784001691	putative PBP binding regions; other site
1415784001692	Protein of unknown function (DUF817); Region: DUF817; pfam05675
1415784001693	Protein of unknown function (DUF4003); Region: DUF4003; pfam13170
1415784001694	DinB superfamily; Region: DinB_2; pfam12867
1415784001695	DinB family; Region: DinB; cl17821
1415784001696	Protein of unknown function (DUF2690); Region: DUF2690; pfam10901
1415784001697	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1415784001698	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1415784001699	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1415784001700	dimerization interface [polypeptide binding]; other site
1415784001701	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1415784001702	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
1415784001703	NADP binding site [chemical binding]; other site
1415784001704	dimer interface [polypeptide binding]; other site
1415784001705	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1415784001706	catalytic core [active]
1415784001707	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784001708	Coenzyme A binding pocket [chemical binding]; other site
1415784001709	DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533
1415784001710	MutS domain III; Region: MutS_III; pfam05192
1415784001711	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1415784001712	Walker A/P-loop; other site
1415784001713	ATP binding site [chemical binding]; other site
1415784001714	Q-loop/lid; other site
1415784001715	ABC transporter signature motif; other site
1415784001716	Walker B; other site
1415784001717	D-loop; other site
1415784001718	H-loop/switch region; other site
1415784001719	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
1415784001720	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
1415784001721	active site
1415784001722	Na/Ca binding site [ion binding]; other site
1415784001723	catalytic site [active]
1415784001724	Domain of unknown function (DUF1939); Region: DUF1939; pfam09154
1415784001725	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
1415784001726	oligoendopeptidase F; Region: pepF; TIGR00181
1415784001727	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
1415784001728	active site
1415784001729	Zn binding site [ion binding]; other site
1415784001730	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
1415784001731	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
1415784001732	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1415784001733	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1415784001734	active site
1415784001735	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1415784001736	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
1415784001737	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1415784001738	DNA binding residues [nucleotide binding]
1415784001739	drug binding residues [chemical binding]; other site
1415784001740	dimer interface [polypeptide binding]; other site
1415784001741	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
1415784001742	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
1415784001743	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
1415784001744	phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833
1415784001745	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
1415784001746	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
1415784001747	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1415784001748	Beta-lactamase; Region: Beta-lactamase; pfam00144
1415784001749	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784001750	putative substrate translocation pore; other site
1415784001751	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1415784001752	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1415784001753	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1415784001754	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
1415784001755	putative dimerization interface [polypeptide binding]; other site
1415784001756	Protein of unknown function (DUF3916); Region: DUF3916; pfam13079
1415784001757	Protein of unknown function (DUF3916); Region: DUF3916; pfam13079
1415784001758	Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601
1415784001759	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1415784001760	active site
1415784001761	catalytic site [active]
1415784001762	metal binding site [ion binding]; metal-binding site
1415784001763	FAD binding domain; Region: FAD_binding_3; pfam01494
1415784001764	hypothetical protein; Provisional; Region: PRK07236
1415784001765	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1415784001766	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1415784001767	dimerization interface [polypeptide binding]; other site
1415784001768	putative DNA binding site [nucleotide binding]; other site
1415784001769	putative Zn2+ binding site [ion binding]; other site
1415784001770	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1415784001771	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1415784001772	putative NAD(P) binding site [chemical binding]; other site
1415784001773	Uncharacterized conserved protein [Function unknown]; Region: COG0397
1415784001774	hypothetical protein; Validated; Region: PRK00029
1415784001775	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1415784001776	TPR motif; other site
1415784001777	binding surface
1415784001778	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
1415784001779	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
1415784001780	Domain of unknown function (DUF4260); Region: DUF4260; pfam14079
1415784001781	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1415784001782	FAD binding domain; Region: FAD_binding_4; pfam01565
1415784001783	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1415784001784	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1415784001785	Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in  bacterial endospore germination.  CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells.  SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874
1415784001786	active site
1415784001787	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1415784001788	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1415784001789	QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360
1415784001790	PAS domain S-box; Region: sensory_box; TIGR00229
1415784001791	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1415784001792	putative active site [active]
1415784001793	heme pocket [chemical binding]; other site
1415784001794	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1415784001795	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1415784001796	metal binding site [ion binding]; metal-binding site
1415784001797	active site
1415784001798	I-site; other site
1415784001799	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1415784001800	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1415784001801	Walker A/P-loop; other site
1415784001802	ATP binding site [chemical binding]; other site
1415784001803	Q-loop/lid; other site
1415784001804	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
1415784001805	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1415784001806	TQXA domain; Region: TQXA_dom; TIGR03934
1415784001807	Cna protein B-type domain; Region: Cna_B; pfam05738
1415784001808	Cna protein B-type domain; Region: Cna_B; pfam05738
1415784001809	Cna protein B-type domain; Region: Cna_B; pfam05738
1415784001810	Cna protein B-type domain; Region: Cna_B; pfam05738
1415784001811	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1415784001812	dimerization interface [polypeptide binding]; other site
1415784001813	putative DNA binding site [nucleotide binding]; other site
1415784001814	putative Zn2+ binding site [ion binding]; other site
1415784001815	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1415784001816	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1415784001817	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1415784001818	dimer interface [polypeptide binding]; other site
1415784001819	phosphorylation site [posttranslational modification]
1415784001820	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784001821	ATP binding site [chemical binding]; other site
1415784001822	Mg2+ binding site [ion binding]; other site
1415784001823	G-X-G motif; other site
1415784001824	Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453
1415784001825	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
1415784001826	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
1415784001827	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
1415784001828	MgtC family; Region: MgtC; pfam02308
1415784001829	Predicted acetyltransferase [General function prediction only]; Region: COG3981
1415784001830	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1415784001831	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
1415784001832	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
1415784001833	putative metal binding site [ion binding]; other site
1415784001834	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1415784001835	active site
1415784001836	VanW like protein; Region: VanW; pfam04294
1415784001837	Protein of unknown function (DUF3900); Region: DUF3900; pfam13039
1415784001838	Domain of unknown function (DUF3898); Region: DUF3898; pfam13037
1415784001839	exonuclease; Provisional; Region: PRK06722
1415784001840	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
1415784001841	active site
1415784001842	catalytic site [active]
1415784001843	substrate binding site [chemical binding]; other site
1415784001844	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1415784001845	DNA-binding site [nucleotide binding]; DNA binding site
1415784001846	RNA-binding motif; other site
1415784001847	flavodoxin; Provisional; Region: PRK06703
1415784001848	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
1415784001849	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1415784001850	nudix motif; other site
1415784001851	ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555
1415784001852	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
1415784001853	trimer interface [polypeptide binding]; other site
1415784001854	active site
1415784001855	substrate binding site [chemical binding]; other site
1415784001856	CoA binding site [chemical binding]; other site
1415784001857	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784001858	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784001859	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784001860	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784001861	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784001862	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784001863	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784001864	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784001865	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784001866	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784001867	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784001868	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784001869	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784001870	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784001871	short chain dehydrogenase; Provisional; Region: PRK06924
1415784001872	sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367
1415784001873	NADP binding site [chemical binding]; other site
1415784001874	homodimer interface [polypeptide binding]; other site
1415784001875	active site
1415784001876	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1415784001877	argininosuccinate lyase; Provisional; Region: PRK06705
1415784001878	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1415784001879	active sites [active]
1415784001880	tetramer interface [polypeptide binding]; other site
1415784001881	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1415784001882	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1415784001883	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455
1415784001884	active site
1415784001885	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1415784001886	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
1415784001887	Na binding site [ion binding]; other site
1415784001888	Protein of unknown function (DUF997); Region: DUF997; pfam06196
1415784001889	ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091
1415784001890	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1415784001891	NAD(P) binding site [chemical binding]; other site
1415784001892	catalytic residues [active]
1415784001893	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1415784001894	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1415784001895	NAD(P) binding site [chemical binding]; other site
1415784001896	homotetramer interface [polypeptide binding]; other site
1415784001897	homodimer interface [polypeptide binding]; other site
1415784001898	active site
1415784001899	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
1415784001900	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
1415784001901	Divergent PAP2 family; Region: DUF212; pfam02681
1415784001902	Predicted permeases [General function prediction only]; Region: RarD; COG2962
1415784001903	EamA-like transporter family; Region: EamA; pfam00892
1415784001904	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
1415784001905	Domain of unknown function DUF59; Region: DUF59; pfam01883
1415784001906	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
1415784001907	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1415784001908	Walker A motif; other site
1415784001909	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1415784001910	MoaE interaction surface [polypeptide binding]; other site
1415784001911	MoeB interaction surface [polypeptide binding]; other site
1415784001912	thiocarboxylated glycine; other site
1415784001913	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1415784001914	MoaE homodimer interface [polypeptide binding]; other site
1415784001915	MoaD interaction [polypeptide binding]; other site
1415784001916	active site residues [active]
1415784001917	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1415784001918	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1415784001919	dimer interface [polypeptide binding]; other site
1415784001920	putative functional site; other site
1415784001921	putative MPT binding site; other site
1415784001922	thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475
1415784001923	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1415784001924	ATP binding site [chemical binding]; other site
1415784001925	substrate interface [chemical binding]; other site
1415784001926	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
1415784001927	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
1415784001928	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1415784001929	FeS/SAM binding site; other site
1415784001930	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1415784001931	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
1415784001932	Uncharacterized conserved protein [Function unknown]; Region: COG5609
1415784001933	Uncharacterized conserved protein [Function unknown]; Region: COG2427
1415784001934	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
1415784001935	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1415784001936	catalytic loop [active]
1415784001937	iron binding site [ion binding]; other site
1415784001938	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1415784001939	4Fe-4S binding domain; Region: Fer4; pfam00037
1415784001940	4Fe-4S binding domain; Region: Fer4; pfam00037
1415784001941	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
1415784001942	[4Fe-4S] binding site [ion binding]; other site
1415784001943	molybdopterin cofactor binding site; other site
1415784001944	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
1415784001945	molybdopterin cofactor binding site; other site
1415784001946	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1415784001947	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1415784001948	amino acid transporter; Region: 2A0306; TIGR00909
1415784001949	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1415784001950	Tubulin like; Region: Tubulin_2; pfam13809
1415784001951	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1415784001952	metal ion-dependent adhesion site (MIDAS); other site
1415784001953	Lactoylglutathione lyase and related lyases [Amino acid transport and metabolism]; Region: GloA; COG0346
1415784001954	short chain dehydrogenase; Provisional; Region: PRK12746
1415784001955	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1415784001956	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784001957	S-adenosylmethionine binding site [chemical binding]; other site
1415784001958	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1415784001959	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1415784001960	peptide binding site [polypeptide binding]; other site
1415784001961	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1415784001962	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1415784001963	peptide binding site [polypeptide binding]; other site
1415784001964	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1415784001965	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1415784001966	peptide binding site [polypeptide binding]; other site
1415784001967	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1415784001968	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1415784001969	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1415784001970	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
1415784001971	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1415784001972	DNA binding residues [nucleotide binding]
1415784001973	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1415784001974	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1415784001975	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1415784001976	Walker A/P-loop; other site
1415784001977	ATP binding site [chemical binding]; other site
1415784001978	Q-loop/lid; other site
1415784001979	ABC transporter signature motif; other site
1415784001980	Walker B; other site
1415784001981	D-loop; other site
1415784001982	H-loop/switch region; other site
1415784001983	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1415784001984	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1415784001985	putative oxidoreductase; Provisional; Region: PRK11579
1415784001986	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1415784001987	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1415784001988	DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061
1415784001989	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1415784001990	CAP-like domain; other site
1415784001991	active site
1415784001992	primary dimer interface [polypeptide binding]; other site
1415784001993	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1415784001994	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1415784001995	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1415784001996	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1415784001997	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784001998	ATP binding site [chemical binding]; other site
1415784001999	Mg2+ binding site [ion binding]; other site
1415784002000	G-X-G motif; other site
1415784002001	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1415784002002	anchoring element; other site
1415784002003	dimer interface [polypeptide binding]; other site
1415784002004	ATP binding site [chemical binding]; other site
1415784002005	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1415784002006	active site
1415784002007	putative metal-binding site [ion binding]; other site
1415784002008	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1415784002009	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
1415784002010	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1415784002011	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1415784002012	protein binding site [polypeptide binding]; other site
1415784002013	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1415784002014	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784002015	active site
1415784002016	phosphorylation site [posttranslational modification]
1415784002017	intermolecular recognition site; other site
1415784002018	dimerization interface [polypeptide binding]; other site
1415784002019	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1415784002020	DNA binding site [nucleotide binding]
1415784002021	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
1415784002022	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1415784002023	FeS/SAM binding site; other site
1415784002024	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704
1415784002025	Class III ribonucleotide reductase; Region: RNR_III; cd01675
1415784002026	effector binding site; other site
1415784002027	active site
1415784002028	Zn binding site [ion binding]; other site
1415784002029	glycine loop; other site
1415784002030	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
1415784002031	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841
1415784002032	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1415784002033	active site
1415784002034	Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858
1415784002035	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1415784002036	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1415784002037	Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in  bacterial endospore germination.  CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells.  SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874
1415784002038	active site
1415784002039	DNA polymerase III subunit epsilon; Validated; Region: PRK06807
1415784002040	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1415784002041	active site
1415784002042	catalytic site [active]
1415784002043	substrate binding site [chemical binding]; other site
1415784002044	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1415784002045	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1415784002046	catalytic residues [active]
1415784002047	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1415784002048	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1415784002049	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1415784002050	Walker A/P-loop; other site
1415784002051	ATP binding site [chemical binding]; other site
1415784002052	Q-loop/lid; other site
1415784002053	ABC transporter signature motif; other site
1415784002054	Walker B; other site
1415784002055	D-loop; other site
1415784002056	H-loop/switch region; other site
1415784002057	aconitate hydratase; Validated; Region: PRK09277
1415784002058	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
1415784002059	substrate binding site [chemical binding]; other site
1415784002060	ligand binding site [chemical binding]; other site
1415784002061	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
1415784002062	substrate binding site [chemical binding]; other site
1415784002063	acid-soluble spore protein O; Provisional; Region: sspO; PRK02984
1415784002064	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1415784002065	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
1415784002066	NodB motif; other site
1415784002067	active site
1415784002068	catalytic site [active]
1415784002069	metal binding site [ion binding]; metal-binding site
1415784002070	Small acid-soluble spore protein P family; Region: SspP; cl12105
1415784002071	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1415784002072	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1415784002073	putative dimer interface [polypeptide binding]; other site
1415784002074	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1415784002075	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784002076	putative substrate translocation pore; other site
1415784002077	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
1415784002078	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1415784002079	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1415784002080	nudix motif; other site
1415784002081	acetyl-CoA acetyltransferase; Provisional; Region: PRK06690
1415784002082	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1415784002083	dimer interface [polypeptide binding]; other site
1415784002084	active site
1415784002085	acyl-CoA synthetase; Validated; Region: PRK07638
1415784002086	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1415784002087	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1415784002088	acyl-activating enzyme (AAE) consensus motif; other site
1415784002089	acyl-activating enzyme (AAE) consensus motif; other site
1415784002090	AMP binding site [chemical binding]; other site
1415784002091	active site
1415784002092	CoA binding site [chemical binding]; other site
1415784002093	BioY family; Region: BioY; pfam02632
1415784002094	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
1415784002095	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
1415784002096	dimer interface [polypeptide binding]; other site
1415784002097	acyl-activating enzyme (AAE) consensus motif; other site
1415784002098	putative active site [active]
1415784002099	AMP binding site [chemical binding]; other site
1415784002100	putative CoA binding site [chemical binding]; other site
1415784002101	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1415784002102	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1415784002103	non-specific DNA binding site [nucleotide binding]; other site
1415784002104	salt bridge; other site
1415784002105	sequence-specific DNA binding site [nucleotide binding]; other site
1415784002106	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1415784002107	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1415784002108	Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932
1415784002109	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1415784002110	amidase catalytic site [active]
1415784002111	Zn binding residues [ion binding]; other site
1415784002112	substrate binding site [chemical binding]; other site
1415784002113	active site
1415784002114	Protein phosphatase 2C; Region: PP2C_2; pfam13672
1415784002115	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1415784002116	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1415784002117	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1415784002118	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
1415784002119	dimer interface [polypeptide binding]; other site
1415784002120	putative metal binding site [ion binding]; other site
1415784002121	PAS domain S-box; Region: sensory_box; TIGR00229
1415784002122	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1415784002123	putative active site [active]
1415784002124	heme pocket [chemical binding]; other site
1415784002125	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1415784002126	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1415784002127	putative active site [active]
1415784002128	heme pocket [chemical binding]; other site
1415784002129	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1415784002130	dimer interface [polypeptide binding]; other site
1415784002131	phosphorylation site [posttranslational modification]
1415784002132	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784002133	ATP binding site [chemical binding]; other site
1415784002134	Mg2+ binding site [ion binding]; other site
1415784002135	G-X-G motif; other site
1415784002136	Predicted esterase [General function prediction only]; Region: COG0400
1415784002137	putative hydrolase; Provisional; Region: PRK11460
1415784002138	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1415784002139	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1415784002140	Zn binding site [ion binding]; other site
1415784002141	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1415784002142	Zn binding site [ion binding]; other site
1415784002143	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
1415784002144	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1415784002145	active site
1415784002146	FMN binding site [chemical binding]; other site
1415784002147	substrate binding site [chemical binding]; other site
1415784002148	3Fe-4S cluster binding site [ion binding]; other site
1415784002149	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1415784002150	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
1415784002151	FMN binding site [chemical binding]; other site
1415784002152	active site
1415784002153	substrate binding site [chemical binding]; other site
1415784002154	catalytic residue [active]
1415784002155	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
1415784002156	agmatinase; Region: agmatinase; TIGR01230
1415784002157	Agmatinase-like family; Region: Agmatinase-like; cd09990
1415784002158	active site
1415784002159	oligomer interface [polypeptide binding]; other site
1415784002160	Mn binding site [ion binding]; other site
1415784002161	imidazolonepropionase; Validated; Region: PRK09356
1415784002162	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
1415784002163	active site
1415784002164	urocanate hydratase; Provisional; Region: PRK05414
1415784002165	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
1415784002166	active sites [active]
1415784002167	tetramer interface [polypeptide binding]; other site
1415784002168	Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640
1415784002169	hexamer interface [polypeptide binding]; other site
1415784002170	RNA binding site [nucleotide binding]; other site
1415784002171	Histidine-zinc binding site [chemical binding]; other site
1415784002172	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784002173	S-adenosylmethionine binding site [chemical binding]; other site
1415784002174	DJ-1 family protein; Region: not_thiJ; TIGR01383
1415784002175	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1415784002176	conserved cys residue [active]
1415784002177	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1415784002178	AAA domain; Region: AAA_28; pfam13521
1415784002179	active site
1415784002180	Protein of unknown function (DUF2621); Region: DUF2621; pfam11084
1415784002181	Protein of unknown function (DUF1453); Region: DUF1453; pfam07301
1415784002182	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1415784002183	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
1415784002184	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1415784002185	EamA-like transporter family; Region: EamA; pfam00892
1415784002186	M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669
1415784002187	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1415784002188	metal binding site [ion binding]; metal-binding site
1415784002189	dimer interface [polypeptide binding]; other site
1415784002190	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1415784002191	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
1415784002192	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1415784002193	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1415784002194	Walker A/P-loop; other site
1415784002195	ATP binding site [chemical binding]; other site
1415784002196	Q-loop/lid; other site
1415784002197	ABC transporter signature motif; other site
1415784002198	Walker B; other site
1415784002199	D-loop; other site
1415784002200	H-loop/switch region; other site
1415784002201	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
1415784002202	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1415784002203	The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452
1415784002204	putative dimerization interface [polypeptide binding]; other site
1415784002205	putative substrate binding pocket [chemical binding]; other site
1415784002206	holin-like protein; Validated; Region: PRK01658
1415784002207	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
1415784002208	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1415784002209	nudix motif; other site
1415784002210	Domain of unknown function (DUF3903); Region: DUF3903; pfam13043
1415784002211	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1415784002212	Nuclease-related domain; Region: NERD; pfam08378
1415784002213	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599
1415784002214	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
1415784002215	active site
1415784002216	Bacterial SH3 domain; Region: SH3_3; pfam08239
1415784002217	Bacterial SH3 domain homologues; Region: SH3b; smart00287
1415784002218	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1415784002219	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1415784002220	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1415784002221	Walker A/P-loop; other site
1415784002222	ATP binding site [chemical binding]; other site
1415784002223	Q-loop/lid; other site
1415784002224	ABC transporter signature motif; other site
1415784002225	Walker B; other site
1415784002226	D-loop; other site
1415784002227	H-loop/switch region; other site
1415784002228	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1415784002229	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
1415784002230	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1415784002231	Walker A/P-loop; other site
1415784002232	ATP binding site [chemical binding]; other site
1415784002233	Q-loop/lid; other site
1415784002234	ABC transporter signature motif; other site
1415784002235	Walker B; other site
1415784002236	D-loop; other site
1415784002237	H-loop/switch region; other site
1415784002238	hypothetical protein; Provisional; Region: PRK01844
1415784002239	Protein of unknown function (DUF2522); Region: DUF2522; pfam10747
1415784002240	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1415784002241	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1415784002242	TPP-binding site [chemical binding]; other site
1415784002243	dimer interface [polypeptide binding]; other site
1415784002244	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1415784002245	PYR/PP interface [polypeptide binding]; other site
1415784002246	dimer interface [polypeptide binding]; other site
1415784002247	TPP binding site [chemical binding]; other site
1415784002248	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1415784002249	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1415784002250	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784002251	dimer interface [polypeptide binding]; other site
1415784002252	conserved gate region; other site
1415784002253	ABC-ATPase subunit interface; other site
1415784002254	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1415784002255	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784002256	dimer interface [polypeptide binding]; other site
1415784002257	conserved gate region; other site
1415784002258	ABC-ATPase subunit interface; other site
1415784002259	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
1415784002260	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
1415784002261	Walker A/P-loop; other site
1415784002262	ATP binding site [chemical binding]; other site
1415784002263	Q-loop/lid; other site
1415784002264	ABC transporter signature motif; other site
1415784002265	Walker B; other site
1415784002266	D-loop; other site
1415784002267	H-loop/switch region; other site
1415784002268	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
1415784002269	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1415784002270	membrane-bound complex binding site; other site
1415784002271	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1415784002272	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1415784002273	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
1415784002274	active site
1415784002275	metal binding site [ion binding]; metal-binding site
1415784002276	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1415784002277	hypothetical protein; Provisional; Region: PRK01546
1415784002278	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1415784002279	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1415784002280	catalytic residues [active]
1415784002281	catalytic nucleophile [active]
1415784002282	LexA repressor; Validated; Region: PRK00215
1415784002283	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1415784002284	putative DNA binding site [nucleotide binding]; other site
1415784002285	putative Zn2+ binding site [ion binding]; other site
1415784002286	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1415784002287	Catalytic site [active]
1415784002288	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
1415784002289	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
1415784002290	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
1415784002291	Protein of unknown function (DUF1700); Region: DUF1700; pfam08006
1415784002292	Predicted transcriptional regulators [Transcription]; Region: COG1695
1415784002293	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1415784002294	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1415784002295	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1415784002296	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1415784002297	Walker A/P-loop; other site
1415784002298	ATP binding site [chemical binding]; other site
1415784002299	Q-loop/lid; other site
1415784002300	ABC transporter signature motif; other site
1415784002301	Walker B; other site
1415784002302	D-loop; other site
1415784002303	H-loop/switch region; other site
1415784002304	Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471
1415784002305	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
1415784002306	active site
1415784002307	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1415784002308	active site
1415784002309	dimer interface [polypeptide binding]; other site
1415784002310	Glutamine amidotransferase domain; Region: GATase_6; pfam13522
1415784002311	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1415784002312	Ligand Binding Site [chemical binding]; other site
1415784002313	Molecular Tunnel; other site
1415784002314	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
1415784002315	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1415784002316	inhibitor-cofactor binding pocket; inhibition site
1415784002317	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784002318	catalytic residue [active]
1415784002319	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1415784002320	REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252
1415784002321	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
1415784002322	carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767
1415784002323	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
1415784002324	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1415784002325	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1415784002326	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
1415784002327	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
1415784002328	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1415784002329	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
1415784002330	putative ADP-binding pocket [chemical binding]; other site
1415784002331	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1415784002332	This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812
1415784002333	putative ADP-binding pocket [chemical binding]; other site
1415784002334	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1415784002335	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1415784002336	active site
1415784002337	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1415784002338	This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812
1415784002339	putative ADP-binding pocket [chemical binding]; other site
1415784002340	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
1415784002341	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
1415784002342	putative ADP-binding pocket [chemical binding]; other site
1415784002343	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
1415784002344	Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719
1415784002345	NAD(P) binding site [chemical binding]; other site
1415784002346	homodimer interface [polypeptide binding]; other site
1415784002347	substrate binding site [chemical binding]; other site
1415784002348	active site
1415784002349	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
1415784002350	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1415784002351	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
1415784002352	Chain length determinant protein; Region: Wzz; cl15801
1415784002353	Protein of unknown function (DUF2762); Region: DUF2762; pfam10960
1415784002354	PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis.  PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b.  Both domains are required for...; Region: GH25_PlyB-like; cd06523
1415784002355	active site
1415784002356	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
1415784002357	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1415784002358	Peptidase family M23; Region: Peptidase_M23; pfam01551
1415784002359	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1415784002360	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1415784002361	catalytic residue [active]
1415784002362	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
1415784002363	DNA binding residues [nucleotide binding]
1415784002364	Helix-turn-helix domain; Region: HTH_36; pfam13730
1415784002365	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
1415784002366	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1415784002367	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713
1415784002368	ORF6C domain; Region: ORF6C; pfam10552
1415784002369	phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111
1415784002370	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1415784002371	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
1415784002372	non-specific DNA binding site [nucleotide binding]; other site
1415784002373	salt bridge; other site
1415784002374	sequence-specific DNA binding site [nucleotide binding]; other site
1415784002375	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1415784002376	Catalytic site [active]
1415784002377	glutamine synthetase, type I; Region: GlnA; TIGR00653
1415784002378	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1415784002379	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1415784002380	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
1415784002381	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1415784002382	DNA binding residues [nucleotide binding]
1415784002383	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
1415784002384	Aluminium resistance protein; Region: Alum_res; pfam06838
1415784002385	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
1415784002386	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1415784002387	HflX GTPase family; Region: HflX; cd01878
1415784002388	G1 box; other site
1415784002389	GTP/Mg2+ binding site [chemical binding]; other site
1415784002390	Switch I region; other site
1415784002391	G2 box; other site
1415784002392	G3 box; other site
1415784002393	Switch II region; other site
1415784002394	G4 box; other site
1415784002395	G5 box; other site
1415784002396	Predicted membrane protein [Function unknown]; Region: COG2860
1415784002397	UPF0126 domain; Region: UPF0126; pfam03458
1415784002398	UPF0126 domain; Region: UPF0126; pfam03458
1415784002399	stage V sporulation protein K; Region: spore_V_K; TIGR02881
1415784002400	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1415784002401	Walker A motif; other site
1415784002402	ATP binding site [chemical binding]; other site
1415784002403	Walker B motif; other site
1415784002404	arginine finger; other site
1415784002405	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
1415784002406	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1415784002407	active site
1415784002408	catalytic residues [active]
1415784002409	DNA binding site [nucleotide binding]
1415784002410	Int/Topo IB signature motif; other site
1415784002411	Protein of unknown function (DUF3982); Region: DUF3982; pfam13138
1415784002412	bacterial Hfq-like; Region: Hfq; cd01716
1415784002413	hexamer interface [polypeptide binding]; other site
1415784002414	Sm1 motif; other site
1415784002415	RNA binding site [nucleotide binding]; other site
1415784002416	Sm2 motif; other site
1415784002417	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1415784002418	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1415784002419	Bacterial SH3 domain; Region: SH3_3; pfam08239
1415784002420	Bacterial SH3 domain; Region: SH3_3; pfam08239
1415784002421	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
1415784002422	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
1415784002423	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1415784002424	active site
1415784002425	phosphorylation site [posttranslational modification]
1415784002426	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1415784002427	active site
1415784002428	P-loop; other site
1415784002429	phosphorylation site [posttranslational modification]
1415784002430	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
1415784002431	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1415784002432	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1415784002433	putative substrate binding site [chemical binding]; other site
1415784002434	putative ATP binding site [chemical binding]; other site
1415784002435	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1415784002436	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1415784002437	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1415784002438	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
1415784002439	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
1415784002440	dimer interface [polypeptide binding]; other site
1415784002441	active site
1415784002442	metal binding site [ion binding]; metal-binding site
1415784002443	Predicted membrane protein [Function unknown]; Region: COG2322
1415784002444	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
1415784002445	GH18 domain of Chitinase D (ChiD).  ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins.  The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871
1415784002446	Glyco_18 domain; Region: Glyco_18; smart00636
1415784002447	putative active site [active]
1415784002448	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1415784002449	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
1415784002450	metal binding site [ion binding]; metal-binding site
1415784002451	dimer interface [polypeptide binding]; other site
1415784002452	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1415784002453	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1415784002454	putative active site [active]
1415784002455	putative metal binding site [ion binding]; other site
1415784002456	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
1415784002457	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1415784002458	IHF dimer interface [polypeptide binding]; other site
1415784002459	IHF - DNA interface [nucleotide binding]; other site
1415784002460	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1415784002461	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784002462	Coenzyme A binding pocket [chemical binding]; other site
1415784002463	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1415784002464	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1415784002465	metal-binding site [ion binding]
1415784002466	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1415784002467	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1415784002468	metal-binding site [ion binding]
1415784002469	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1415784002470	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1415784002471	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1415784002472	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1415784002473	metal-binding site [ion binding]
1415784002474	Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157
1415784002475	putative homodimer interface [polypeptide binding]; other site
1415784002476	putative homotetramer interface [polypeptide binding]; other site
1415784002477	allosteric switch controlling residues; other site
1415784002478	putative metal binding site [ion binding]; other site
1415784002479	putative homodimer-homodimer interface [polypeptide binding]; other site
1415784002480	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1415784002481	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1415784002482	DNA binding residues [nucleotide binding]
1415784002483	dimerization interface [polypeptide binding]; other site
1415784002484	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1415784002485	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784002486	S-adenosylmethionine binding site [chemical binding]; other site
1415784002487	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1415784002488	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1415784002489	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1415784002490	Walker A/P-loop; other site
1415784002491	ATP binding site [chemical binding]; other site
1415784002492	Q-loop/lid; other site
1415784002493	ABC transporter signature motif; other site
1415784002494	Walker B; other site
1415784002495	D-loop; other site
1415784002496	H-loop/switch region; other site
1415784002497	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1415784002498	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1415784002499	ABC-ATPase subunit  interface; other site
1415784002500	dimer interface [polypeptide binding]; other site
1415784002501	putative PBP binding regions; other site
1415784002502	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1415784002503	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1415784002504	ABC-ATPase subunit  interface; other site
1415784002505	dimer interface [polypeptide binding]; other site
1415784002506	putative PBP binding regions; other site
1415784002507	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
1415784002508	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1415784002509	putative ligand binding residues [chemical binding]; other site
1415784002510	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
1415784002511	active site
1415784002512	putative catalytic site [active]
1415784002513	DNA binding site [nucleotide binding]
1415784002514	putative phosphate binding site [ion binding]; other site
1415784002515	metal binding site A [ion binding]; metal-binding site
1415784002516	AP binding site [nucleotide binding]; other site
1415784002517	metal binding site B [ion binding]; metal-binding site
1415784002518	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
1415784002519	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
1415784002520	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1415784002521	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1415784002522	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1415784002523	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1415784002524	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1415784002525	DNA binding site [nucleotide binding]
1415784002526	active site
1415784002527	8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934
1415784002528	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
1415784002529	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1415784002530	minor groove reading motif; other site
1415784002531	helix-hairpin-helix signature motif; other site
1415784002532	substrate binding pocket [chemical binding]; other site
1415784002533	active site
1415784002534	peptidase T; Region: peptidase-T; TIGR01882
1415784002535	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
1415784002536	metal binding site [ion binding]; metal-binding site
1415784002537	dimer interface [polypeptide binding]; other site
1415784002538	Predicted membrane protein [Function unknown]; Region: COG2364
1415784002539	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1415784002540	hypothetical protein; Provisional; Region: PRK06764
1415784002541	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1415784002542	catalytic core [active]
1415784002543	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1415784002544	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
1415784002545	PAS domain S-box; Region: sensory_box; TIGR00229
1415784002546	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1415784002547	putative active site [active]
1415784002548	heme pocket [chemical binding]; other site
1415784002549	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1415784002550	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1415784002551	metal binding site [ion binding]; metal-binding site
1415784002552	active site
1415784002553	I-site; other site
1415784002554	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1415784002555	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446
1415784002556	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1415784002557	active site
1415784002558	homodimer interface [polypeptide binding]; other site
1415784002559	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1415784002560	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1415784002561	NAD(P) binding site [chemical binding]; other site
1415784002562	active site
1415784002563	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
1415784002564	Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719
1415784002565	NAD(P) binding site [chemical binding]; other site
1415784002566	homodimer interface [polypeptide binding]; other site
1415784002567	substrate binding site [chemical binding]; other site
1415784002568	active site
1415784002569	Protein of unknown function (DUF2515); Region: DUF2515; pfam10720
1415784002570	Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787
1415784002571	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
1415784002572	holin-like protein; Validated; Region: PRK01658
1415784002573	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1415784002574	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1415784002575	DNA-binding site [nucleotide binding]; DNA binding site
1415784002576	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1415784002577	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784002578	homodimer interface [polypeptide binding]; other site
1415784002579	catalytic residue [active]
1415784002580	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1415784002581	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1415784002582	bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000
1415784002583	Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137
1415784002584	active site
1415784002585	catalytic site [active]
1415784002586	Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843
1415784002587	putative active site [active]
1415784002588	putative catalytic triad [active]
1415784002589	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
1415784002590	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1415784002591	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1415784002592	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1415784002593	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
1415784002594	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
1415784002595	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1415784002596	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1415784002597	Sulfatase; Region: Sulfatase; pfam00884
1415784002598	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1415784002599	binding surface
1415784002600	TPR motif; other site
1415784002601	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1415784002602	G1 box; other site
1415784002603	GTP/Mg2+ binding site [chemical binding]; other site
1415784002604	Switch I region; other site
1415784002605	G3 box; other site
1415784002606	Switch II region; other site
1415784002607	G4 box; other site
1415784002608	G5 box; other site
1415784002609	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
1415784002610	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784002611	ATP binding site [chemical binding]; other site
1415784002612	Mg2+ binding site [ion binding]; other site
1415784002613	G-X-G motif; other site
1415784002614	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
1415784002615	ATP binding site [chemical binding]; other site
1415784002616	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
1415784002617	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1415784002618	MutS domain I; Region: MutS_I; pfam01624
1415784002619	MutS domain II; Region: MutS_II; pfam05188
1415784002620	MutS domain III; Region: MutS_III; pfam05192
1415784002621	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
1415784002622	Walker A/P-loop; other site
1415784002623	ATP binding site [chemical binding]; other site
1415784002624	Q-loop/lid; other site
1415784002625	ABC transporter signature motif; other site
1415784002626	Walker B; other site
1415784002627	D-loop; other site
1415784002628	H-loop/switch region; other site
1415784002629	Outer spore coat protein E (CotE); Region: CotE; pfam10628
1415784002630	Predicted membrane protein [Function unknown]; Region: COG4550
1415784002631	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327
1415784002632	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1415784002633	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1415784002634	FeS/SAM binding site; other site
1415784002635	TRAM domain; Region: TRAM; pfam01938
1415784002636	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
1415784002637	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
1415784002638	TPP-binding site [chemical binding]; other site
1415784002639	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
1415784002640	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
1415784002641	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
1415784002642	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1415784002643	dimer interface [polypeptide binding]; other site
1415784002644	PYR/PP interface [polypeptide binding]; other site
1415784002645	TPP binding site [chemical binding]; other site
1415784002646	substrate binding site [chemical binding]; other site
1415784002647	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1415784002648	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
1415784002649	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
1415784002650	active site
1415784002651	dimer interface [polypeptide binding]; other site
1415784002652	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
1415784002653	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
1415784002654	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1415784002655	putative active site [active]
1415784002656	metal binding site [ion binding]; metal-binding site
1415784002657	homodimer binding site [polypeptide binding]; other site
1415784002658	phosphodiesterase; Provisional; Region: PRK12704
1415784002659	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1415784002660	Zn2+ binding site [ion binding]; other site
1415784002661	Mg2+ binding site [ion binding]; other site
1415784002662	recA bacterial DNA recombination protein; Region: RecA; cl17211
1415784002663	recA bacterial DNA recombination protein; Region: RecA; cl17211
1415784002664	competence damage-inducible protein A; Provisional; Region: PRK00549
1415784002665	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
1415784002666	putative MPT binding site; other site
1415784002667	Competence-damaged protein; Region: CinA; pfam02464
1415784002668	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560
1415784002669	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1415784002670	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1415784002671	non-specific DNA binding site [nucleotide binding]; other site
1415784002672	salt bridge; other site
1415784002673	sequence-specific DNA binding site [nucleotide binding]; other site
1415784002674	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
1415784002675	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1415784002676	Protein of unknown function (DUF3388); Region: DUF3388; pfam11868
1415784002677	Protein of unknown function (DUF3243); Region: DUF3243; pfam11588
1415784002678	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
1415784002679	classical (c) SDRs; Region: SDR_c; cd05233
1415784002680	NAD(P) binding site [chemical binding]; other site
1415784002681	active site
1415784002682	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1415784002683	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1415784002684	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1415784002685	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1415784002686	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1415784002687	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1415784002688	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1415784002689	TM-ABC transporter signature motif; other site
1415784002690	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1415784002691	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1415784002692	TM-ABC transporter signature motif; other site
1415784002693	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
1415784002694	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1415784002695	Walker A/P-loop; other site
1415784002696	ATP binding site [chemical binding]; other site
1415784002697	Q-loop/lid; other site
1415784002698	ABC transporter signature motif; other site
1415784002699	Walker B; other site
1415784002700	D-loop; other site
1415784002701	H-loop/switch region; other site
1415784002702	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1415784002703	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
1415784002704	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
1415784002705	ligand binding site [chemical binding]; other site
1415784002706	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1415784002707	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1415784002708	DNA-binding site [nucleotide binding]; DNA binding site
1415784002709	UTRA domain; Region: UTRA; pfam07702
1415784002710	Tetraspanin family; Region: Tetraspannin; pfam00335
1415784002711	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1415784002712	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1415784002713	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1415784002714	YlzJ-like protein; Region: YlzJ; pfam14035
1415784002715	Clp protease; Region: CLP_protease; pfam00574
1415784002716	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
1415784002717	active site
1415784002718	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1415784002719	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1415784002720	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1415784002721	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1415784002722	dihydrodipicolinate synthase; Region: dapA; TIGR00674
1415784002723	dimer interface [polypeptide binding]; other site
1415784002724	active site
1415784002725	catalytic residue [active]
1415784002726	aspartate kinase I; Reviewed; Region: PRK08210
1415784002727	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
1415784002728	nucleotide binding site [chemical binding]; other site
1415784002729	substrate binding site [chemical binding]; other site
1415784002730	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914
1415784002731	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937
1415784002732	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1415784002733	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1415784002734	dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305
1415784002735	dipicolinate synthase subunit A; Reviewed; Region: PRK08306
1415784002736	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
1415784002737	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
1415784002738	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1415784002739	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1415784002740	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1415784002741	probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873
1415784002742	Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950
1415784002743	NodB motif; other site
1415784002744	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1415784002745	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
1415784002746	RNase E interface [polypeptide binding]; other site
1415784002747	trimer interface [polypeptide binding]; other site
1415784002748	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1415784002749	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1415784002750	RNase E interface [polypeptide binding]; other site
1415784002751	trimer interface [polypeptide binding]; other site
1415784002752	active site
1415784002753	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1415784002754	putative nucleic acid binding region [nucleotide binding]; other site
1415784002755	G-X-X-G motif; other site
1415784002756	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1415784002757	RNA binding site [nucleotide binding]; other site
1415784002758	domain interface; other site
1415784002759	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1415784002760	16S/18S rRNA binding site [nucleotide binding]; other site
1415784002761	S13e-L30e interaction site [polypeptide binding]; other site
1415784002762	25S rRNA binding site [nucleotide binding]; other site
1415784002763	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1415784002764	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1415784002765	active site
1415784002766	Riboflavin kinase; Region: Flavokinase; pfam01687
1415784002767	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550
1415784002768	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1415784002769	RNA binding site [nucleotide binding]; other site
1415784002770	active site
1415784002771	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1415784002772	Protein of unknown function (DUF503); Region: DUF503; pfam04456
1415784002773	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1415784002774	translation initiation factor IF-2; Region: IF-2; TIGR00487
1415784002775	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1415784002776	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1415784002777	G1 box; other site
1415784002778	putative GEF interaction site [polypeptide binding]; other site
1415784002779	GTP/Mg2+ binding site [chemical binding]; other site
1415784002780	Switch I region; other site
1415784002781	G2 box; other site
1415784002782	G3 box; other site
1415784002783	Switch II region; other site
1415784002784	G4 box; other site
1415784002785	G5 box; other site
1415784002786	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1415784002787	Translation-initiation factor 2; Region: IF-2; pfam11987
1415784002788	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1415784002789	hypothetical protein; Provisional; Region: PRK07714
1415784002790	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
1415784002791	putative RNA binding cleft [nucleotide binding]; other site
1415784002792	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
1415784002793	NusA N-terminal domain; Region: NusA_N; pfam08529
1415784002794	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1415784002795	RNA binding site [nucleotide binding]; other site
1415784002796	homodimer interface [polypeptide binding]; other site
1415784002797	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1415784002798	G-X-X-G motif; other site
1415784002799	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1415784002800	G-X-X-G motif; other site
1415784002801	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1415784002802	Sm and related proteins; Region: Sm_like; cl00259
1415784002803	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1415784002804	putative oligomer interface [polypeptide binding]; other site
1415784002805	putative RNA binding site [nucleotide binding]; other site
1415784002806	DNA polymerase III PolC; Validated; Region: polC; PRK00448
1415784002807	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
1415784002808	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
1415784002809	generic binding surface II; other site
1415784002810	generic binding surface I; other site
1415784002811	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1415784002812	active site
1415784002813	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1415784002814	active site
1415784002815	catalytic site [active]
1415784002816	substrate binding site [chemical binding]; other site
1415784002817	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
1415784002818	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1415784002819	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1415784002820	dimer interface [polypeptide binding]; other site
1415784002821	motif 1; other site
1415784002822	active site
1415784002823	motif 2; other site
1415784002824	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1415784002825	putative deacylase active site [active]
1415784002826	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1415784002827	active site
1415784002828	motif 3; other site
1415784002829	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1415784002830	anticodon binding site; other site
1415784002831	RIP metalloprotease RseP; Region: TIGR00054
1415784002832	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1415784002833	active site
1415784002834	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1415784002835	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1415784002836	protein binding site [polypeptide binding]; other site
1415784002837	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1415784002838	putative substrate binding region [chemical binding]; other site
1415784002839	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
1415784002840	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1415784002841	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1415784002842	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1415784002843	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1415784002844	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1415784002845	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1415784002846	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
1415784002847	catalytic residue [active]
1415784002848	putative FPP diphosphate  binding site; other site
1415784002849	putative FPP binding hydrophobic cleft; other site
1415784002850	dimer interface [polypeptide binding]; other site
1415784002851	putative IPP diphosphate binding site; other site
1415784002852	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1415784002853	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1415784002854	hinge region; other site
1415784002855	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1415784002856	putative nucleotide binding site [chemical binding]; other site
1415784002857	uridine monophosphate binding site [chemical binding]; other site
1415784002858	homohexameric interface [polypeptide binding]; other site
1415784002859	elongation factor Ts; Provisional; Region: tsf; PRK09377
1415784002860	UBA/TS-N domain; Region: UBA; pfam00627
1415784002861	Elongation factor TS; Region: EF_TS; pfam00889
1415784002862	Elongation factor TS; Region: EF_TS; pfam00889
1415784002863	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1415784002864	rRNA interaction site [nucleotide binding]; other site
1415784002865	S8 interaction site; other site
1415784002866	putative laminin-1 binding site; other site
1415784002867	transcriptional repressor CodY; Validated; Region: PRK04158
1415784002868	CodY GAF-like domain; Region: CodY; pfam06018
1415784002869	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
1415784002870	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
1415784002871	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1415784002872	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1415784002873	Walker A motif; other site
1415784002874	ATP binding site [chemical binding]; other site
1415784002875	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
1415784002876	active site
1415784002877	HslU subunit interaction site [polypeptide binding]; other site
1415784002878	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1415784002879	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1415784002880	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
1415784002881	Glucose inhibited division protein A; Region: GIDA; pfam01134
1415784002882	DNA topoisomerase I; Validated; Region: PRK05582
1415784002883	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1415784002884	active site
1415784002885	interdomain interaction site; other site
1415784002886	putative metal-binding site [ion binding]; other site
1415784002887	nucleotide binding site [chemical binding]; other site
1415784002888	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1415784002889	domain I; other site
1415784002890	DNA binding groove [nucleotide binding]
1415784002891	phosphate binding site [ion binding]; other site
1415784002892	domain II; other site
1415784002893	domain III; other site
1415784002894	nucleotide binding site [chemical binding]; other site
1415784002895	catalytic site [active]
1415784002896	domain IV; other site
1415784002897	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1415784002898	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1415784002899	DNA protecting protein DprA; Region: dprA; TIGR00732
1415784002900	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
1415784002901	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
1415784002902	CoA binding domain; Region: CoA_binding; smart00881
1415784002903	CoA-ligase; Region: Ligase_CoA; pfam00549
1415784002904	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
1415784002905	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1415784002906	CoA-ligase; Region: Ligase_CoA; pfam00549
1415784002907	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1415784002908	RNA/DNA hybrid binding site [nucleotide binding]; other site
1415784002909	active site
1415784002910	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
1415784002911	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
1415784002912	GTP/Mg2+ binding site [chemical binding]; other site
1415784002913	G4 box; other site
1415784002914	G5 box; other site
1415784002915	50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926
1415784002916	G1 box; other site
1415784002917	G1 box; other site
1415784002918	GTP/Mg2+ binding site [chemical binding]; other site
1415784002919	Switch I region; other site
1415784002920	G2 box; other site
1415784002921	G2 box; other site
1415784002922	G3 box; other site
1415784002923	G3 box; other site
1415784002924	Switch II region; other site
1415784002925	Switch II region; other site
1415784002926	G4 box; other site
1415784002927	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1415784002928	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1415784002929	Catalytic site [active]
1415784002930	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1415784002931	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1415784002932	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1415784002933	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1415784002934	RimM N-terminal domain; Region: RimM; pfam01782
1415784002935	PRC-barrel domain; Region: PRC; pfam05239
1415784002936	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
1415784002937	KH domain; Region: KH_4; pfam13083
1415784002938	G-X-X-G motif; other site
1415784002939	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
1415784002940	signal recognition particle protein; Provisional; Region: PRK10867
1415784002941	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1415784002942	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1415784002943	P loop; other site
1415784002944	GTP binding site [chemical binding]; other site
1415784002945	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1415784002946	putative DNA-binding protein; Validated; Region: PRK00118
1415784002947	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
1415784002948	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1415784002949	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1415784002950	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1415784002951	P loop; other site
1415784002952	GTP binding site [chemical binding]; other site
1415784002953	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1415784002954	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1415784002955	Walker A/P-loop; other site
1415784002956	ATP binding site [chemical binding]; other site
1415784002957	Q-loop/lid; other site
1415784002958	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
1415784002959	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1415784002960	ABC transporter signature motif; other site
1415784002961	Walker B; other site
1415784002962	D-loop; other site
1415784002963	H-loop/switch region; other site
1415784002964	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
1415784002965	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1415784002966	dimerization interface [polypeptide binding]; other site
1415784002967	active site
1415784002968	metal binding site [ion binding]; metal-binding site
1415784002969	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1415784002970	dsRNA binding site [nucleotide binding]; other site
1415784002971	acyl carrier protein; Provisional; Region: acpP; PRK00982
1415784002972	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1415784002973	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1415784002974	NAD(P) binding site [chemical binding]; other site
1415784002975	homotetramer interface [polypeptide binding]; other site
1415784002976	homodimer interface [polypeptide binding]; other site
1415784002977	active site
1415784002978	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1415784002979	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1415784002980	putative phosphate acyltransferase; Provisional; Region: PRK05331
1415784002981	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
1415784002982	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
1415784002983	active site 2 [active]
1415784002984	active site 1 [active]
1415784002985	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1415784002986	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1415784002987	generic binding surface II; other site
1415784002988	ssDNA binding site; other site
1415784002989	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1415784002990	ATP binding site [chemical binding]; other site
1415784002991	putative Mg++ binding site [ion binding]; other site
1415784002992	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1415784002993	nucleotide binding region [chemical binding]; other site
1415784002994	ATP-binding site [chemical binding]; other site
1415784002995	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
1415784002996	DAK2 domain; Region: Dak2; pfam02734
1415784002997	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
1415784002998	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1415784002999	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
1415784003000	Thiamine pyrophosphokinase; Region: TPK; cd07995
1415784003001	active site
1415784003002	dimerization interface [polypeptide binding]; other site
1415784003003	thiamine binding site [chemical binding]; other site
1415784003004	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1415784003005	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1415784003006	substrate binding site [chemical binding]; other site
1415784003007	hexamer interface [polypeptide binding]; other site
1415784003008	metal binding site [ion binding]; metal-binding site
1415784003009	GTPase RsgA; Reviewed; Region: PRK00098
1415784003010	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
1415784003011	RNA binding site [nucleotide binding]; other site
1415784003012	homodimer interface [polypeptide binding]; other site
1415784003013	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1415784003014	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1415784003015	GTP/Mg2+ binding site [chemical binding]; other site
1415784003016	G4 box; other site
1415784003017	G5 box; other site
1415784003018	G1 box; other site
1415784003019	Switch I region; other site
1415784003020	G2 box; other site
1415784003021	G3 box; other site
1415784003022	Switch II region; other site
1415784003023	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1415784003024	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1415784003025	active site
1415784003026	ATP binding site [chemical binding]; other site
1415784003027	substrate binding site [chemical binding]; other site
1415784003028	activation loop (A-loop); other site
1415784003029	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
1415784003030	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1415784003031	PASTA domain; Region: PASTA; pfam03793
1415784003032	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1415784003033	Protein phosphatase 2C; Region: PP2C; pfam00481
1415784003034	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1415784003035	active site
1415784003036	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
1415784003037	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1415784003038	FeS/SAM binding site; other site
1415784003039	16S rRNA methyltransferase B; Provisional; Region: PRK14902
1415784003040	NusB family; Region: NusB; pfam01029
1415784003041	putative RNA binding site [nucleotide binding]; other site
1415784003042	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784003043	S-adenosylmethionine binding site [chemical binding]; other site
1415784003044	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1415784003045	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1415784003046	putative active site [active]
1415784003047	substrate binding site [chemical binding]; other site
1415784003048	putative cosubstrate binding site; other site
1415784003049	catalytic site [active]
1415784003050	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1415784003051	substrate binding site [chemical binding]; other site
1415784003052	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1415784003053	active site
1415784003054	catalytic residues [active]
1415784003055	metal binding site [ion binding]; metal-binding site
1415784003056	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1415784003057	primosomal protein N' Region: priA; TIGR00595
1415784003058	ATP binding site [chemical binding]; other site
1415784003059	putative Mg++ binding site [ion binding]; other site
1415784003060	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1415784003061	nucleotide binding region [chemical binding]; other site
1415784003062	ATP-binding site [chemical binding]; other site
1415784003063	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1415784003064	Flavoprotein; Region: Flavoprotein; pfam02441
1415784003065	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1415784003066	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
1415784003067	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1415784003068	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1415784003069	catalytic site [active]
1415784003070	G-X2-G-X-G-K; other site
1415784003071	hypothetical protein; Provisional; Region: PRK04323
1415784003072	hypothetical protein; Provisional; Region: PRK11820
1415784003073	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
1415784003074	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
1415784003075	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1415784003076	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
1415784003077	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1415784003078	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1415784003079	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1415784003080	motif II; other site
1415784003081	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1415784003082	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
1415784003083	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
1415784003084	Domain of unknown function (DUF814); Region: DUF814; pfam05670
1415784003085	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1415784003086	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1415784003087	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1415784003088	active site
1415784003089	Protein of unknown function (DUF664); Region: DUF664; pfam04978
1415784003090	DinB superfamily; Region: DinB_2; pfam12867
1415784003091	YoqO-like protein; Region: YoqO; pfam14037
1415784003092	YoqO-like protein; Region: YoqO; pfam14037
1415784003093	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
1415784003094	Helix-turn-helix domain; Region: HTH_36; pfam13730
1415784003095	Predicted transcriptional regulator [Transcription]; Region: COG3355
1415784003096	multiple promoter invertase; Provisional; Region: mpi; PRK13413
1415784003097	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1415784003098	catalytic residues [active]
1415784003099	catalytic nucleophile [active]
1415784003100	Presynaptic Site I dimer interface [polypeptide binding]; other site
1415784003101	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1415784003102	Synaptic Flat tetramer interface [polypeptide binding]; other site
1415784003103	Synaptic Site I dimer interface [polypeptide binding]; other site
1415784003104	DNA binding site [nucleotide binding]
1415784003105	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1415784003106	DNA-binding interface [nucleotide binding]; DNA binding site
1415784003107	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1415784003108	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1415784003109	catalytic residues [active]
1415784003110	catalytic nucleophile [active]
1415784003111	Recombinase; Region: Recombinase; pfam07508
1415784003112	Protein of unknown function (DUF2651); Region: DUF2651; pfam10852
1415784003113	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1415784003114	active site
1415784003115	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1415784003116	active site
1415784003117	dimer interface [polypeptide binding]; other site
1415784003118	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
1415784003119	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
1415784003120	heterodimer interface [polypeptide binding]; other site
1415784003121	active site
1415784003122	FMN binding site [chemical binding]; other site
1415784003123	homodimer interface [polypeptide binding]; other site
1415784003124	substrate binding site [chemical binding]; other site
1415784003125	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
1415784003126	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
1415784003127	FAD binding pocket [chemical binding]; other site
1415784003128	FAD binding motif [chemical binding]; other site
1415784003129	phosphate binding motif [ion binding]; other site
1415784003130	beta-alpha-beta structure motif; other site
1415784003131	NAD binding pocket [chemical binding]; other site
1415784003132	Iron coordination center [ion binding]; other site
1415784003133	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1415784003134	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1415784003135	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1415784003136	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1415784003137	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1415784003138	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1415784003139	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1415784003140	IMP binding site; other site
1415784003141	dimer interface [polypeptide binding]; other site
1415784003142	interdomain contacts; other site
1415784003143	partial ornithine binding site; other site
1415784003144	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1415784003145	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1415784003146	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1415784003147	catalytic site [active]
1415784003148	subunit interface [polypeptide binding]; other site
1415784003149	dihydroorotase; Validated; Region: pyrC; PRK09357
1415784003150	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1415784003151	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1415784003152	active site
1415784003153	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1415784003154	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1415784003155	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1415784003156	uracil transporter; Provisional; Region: PRK10720
1415784003157	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1415784003158	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1415784003159	active site
1415784003160	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
1415784003161	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1415784003162	RNA binding surface [nucleotide binding]; other site
1415784003163	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1415784003164	active site
1415784003165	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
1415784003166	lipoprotein signal peptidase; Provisional; Region: PRK14787
1415784003167	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
1415784003168	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
1415784003169	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1415784003170	active site
1415784003171	HIGH motif; other site
1415784003172	nucleotide binding site [chemical binding]; other site
1415784003173	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1415784003174	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1415784003175	active site
1415784003176	KMSKS motif; other site
1415784003177	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1415784003178	tRNA binding surface [nucleotide binding]; other site
1415784003179	anticodon binding site; other site
1415784003180	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1415784003181	DivIVA protein; Region: DivIVA; pfam05103
1415784003182	DivIVA domain; Region: DivI1A_domain; TIGR03544
1415784003183	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
1415784003184	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
1415784003185	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1415784003186	RNA binding surface [nucleotide binding]; other site
1415784003187	YGGT family; Region: YGGT; pfam02325
1415784003188	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
1415784003189	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
1415784003190	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1415784003191	catalytic residue [active]
1415784003192	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
1415784003193	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
1415784003194	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
1415784003195	sporulation sigma factor SigG; Reviewed; Region: PRK08215
1415784003196	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1415784003197	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1415784003198	DNA binding residues [nucleotide binding]
1415784003199	sporulation sigma factor SigE; Reviewed; Region: PRK08301
1415784003200	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1415784003201	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1415784003202	DNA binding residues [nucleotide binding]
1415784003203	Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419
1415784003204	sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854
1415784003205	cell division protein FtsZ; Validated; Region: PRK09330
1415784003206	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1415784003207	nucleotide binding site [chemical binding]; other site
1415784003208	SulA interaction site; other site
1415784003209	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
1415784003210	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1415784003211	nucleotide binding site [chemical binding]; other site
1415784003212	SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491
1415784003213	Cell division protein FtsA; Region: FtsA; pfam14450
1415784003214	Domain of unknown function (DUF3484); Region: DUF3484; pfam11983
1415784003215	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1415784003216	Cell division protein FtsQ; Region: FtsQ; pfam03799
1415784003217	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
1415784003218	FAD binding domain; Region: FAD_binding_4; pfam01565
1415784003219	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1415784003220	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1415784003221	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1415784003222	active site
1415784003223	homodimer interface [polypeptide binding]; other site
1415784003224	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
1415784003225	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
1415784003226	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
1415784003227	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1415784003228	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1415784003229	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1415784003230	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1415784003231	Mg++ binding site [ion binding]; other site
1415784003232	putative catalytic motif [active]
1415784003233	putative substrate binding site [chemical binding]; other site
1415784003234	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1415784003235	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1415784003236	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1415784003237	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1415784003238	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
1415784003239	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1415784003240	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1415784003241	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573
1415784003242	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1415784003243	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1415784003244	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1415784003245	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
1415784003246	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
1415784003247	Cell division protein FtsL; Region: FtsL; cl11433
1415784003248	MraW methylase family; Region: Methyltransf_5; pfam01795
1415784003249	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
1415784003250	bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998
1415784003251	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
1415784003252	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
1415784003253	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1415784003254	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1415784003255	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1415784003256	hypothetical protein; Provisional; Region: PRK13688
1415784003257	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784003258	Coenzyme A binding pocket [chemical binding]; other site
1415784003259	transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894
1415784003260	putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923
1415784003261	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
1415784003262	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
1415784003263	hypothetical protein; Provisional; Region: PRK13670
1415784003264	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
1415784003265	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
1415784003266	PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986
1415784003267	protein binding site [polypeptide binding]; other site
1415784003268	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1415784003269	hypothetical protein; Provisional; Region: PRK10279
1415784003270	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
1415784003271	active site
1415784003272	nucleophile elbow; other site
1415784003273	sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871
1415784003274	Nucleoside recognition; Region: Gate; pfam07670
1415784003275	Nucleoside recognition; Region: Gate; pfam07670
1415784003276	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1415784003277	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1415784003278	active site
1415784003279	(T/H)XGH motif; other site
1415784003280	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
1415784003281	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784003282	S-adenosylmethionine binding site [chemical binding]; other site
1415784003283	hypothetical protein; Provisional; Region: PRK02886
1415784003284	Protein of unknown function (DUF964); Region: DUF964; pfam06133
1415784003285	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1415784003286	catalytic core [active]
1415784003287	YlbE-like protein; Region: YlbE; pfam14003
1415784003288	Putative coat protein; Region: YlbD_coat; pfam14071
1415784003289	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
1415784003290	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1415784003291	YugN-like family; Region: YugN; pfam08868
1415784003292	formamidase; Provisional; Region: amiF; PRK13287
1415784003293	aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565
1415784003294	multimer interface [polypeptide binding]; other site
1415784003295	active site
1415784003296	catalytic triad [active]
1415784003297	dimer interface [polypeptide binding]; other site
1415784003298	cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737
1415784003299	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
1415784003300	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
1415784003301	Subunit I/III interface [polypeptide binding]; other site
1415784003302	Subunit III/IV interface [polypeptide binding]; other site
1415784003303	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1415784003304	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1415784003305	D-pathway; other site
1415784003306	Putative ubiquinol binding site [chemical binding]; other site
1415784003307	Low-spin heme (heme b) binding site [chemical binding]; other site
1415784003308	Putative water exit pathway; other site
1415784003309	Binuclear center (heme o3/CuB) [ion binding]; other site
1415784003310	K-pathway; other site
1415784003311	Putative proton exit pathway; other site
1415784003312	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
1415784003313	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1415784003314	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1415784003315	Cytochrome c; Region: Cytochrom_C; pfam00034
1415784003316	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
1415784003317	UbiA prenyltransferase family; Region: UbiA; pfam01040
1415784003318	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
1415784003319	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
1415784003320	pyruvate carboxylase; Reviewed; Region: PRK12999
1415784003321	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1415784003322	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1415784003323	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1415784003324	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1415784003325	active site
1415784003326	catalytic residues [active]
1415784003327	metal binding site [ion binding]; metal-binding site
1415784003328	homodimer binding site [polypeptide binding]; other site
1415784003329	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1415784003330	carboxyltransferase (CT) interaction site; other site
1415784003331	biotinylation site [posttranslational modification]; other site
1415784003332	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
1415784003333	hypothetical protein; Provisional; Region: PRK13666
1415784003334	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1415784003335	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
1415784003336	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
1415784003337	putative active site [active]
1415784003338	PhoH-like protein; Region: PhoH; pfam02562
1415784003339	hypothetical protein; Provisional; Region: PRK06733
1415784003340	Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963
1415784003341	YlaH-like protein; Region: YlaH; pfam14036
1415784003342	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1415784003343	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1415784003344	G1 box; other site
1415784003345	putative GEF interaction site [polypeptide binding]; other site
1415784003346	GTP/Mg2+ binding site [chemical binding]; other site
1415784003347	Switch I region; other site
1415784003348	G2 box; other site
1415784003349	G3 box; other site
1415784003350	Switch II region; other site
1415784003351	G4 box; other site
1415784003352	G5 box; other site
1415784003353	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1415784003354	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1415784003355	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1415784003356	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
1415784003357	active site
1415784003358	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493
1415784003359	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
1415784003360	hypothetical protein; Provisional; Region: PRK04387
1415784003361	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
1415784003362	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
1415784003363	homodimer interface [polypeptide binding]; other site
1415784003364	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784003365	catalytic residue [active]
1415784003366	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1415784003367	transglutaminase; Provisional; Region: tgl; PRK03187
1415784003368	Protein of unknown function (DUF3055); Region: DUF3055; pfam11256
1415784003369	Domain of unknown function (DUF1885); Region: DUF1885; pfam08968
1415784003370	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
1415784003371	DHHW protein; Region: DHHW; pfam14286
1415784003372	DHHW protein; Region: DHHW; pfam14286
1415784003373	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
1415784003374	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1415784003375	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1415784003376	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1415784003377	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1415784003378	E3 interaction surface; other site
1415784003379	lipoyl attachment site [posttranslational modification]; other site
1415784003380	e3 binding domain; Region: E3_binding; pfam02817
1415784003381	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1415784003382	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1415784003383	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1415784003384	alpha subunit interface [polypeptide binding]; other site
1415784003385	TPP binding site [chemical binding]; other site
1415784003386	heterodimer interface [polypeptide binding]; other site
1415784003387	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1415784003388	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
1415784003389	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1415784003390	TPP-binding site [chemical binding]; other site
1415784003391	heterodimer interface [polypeptide binding]; other site
1415784003392	tetramer interface [polypeptide binding]; other site
1415784003393	phosphorylation loop region [posttranslational modification]
1415784003394	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1415784003395	active site
1415784003396	catalytic residues [active]
1415784003397	metal binding site [ion binding]; metal-binding site
1415784003398	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1415784003399	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1415784003400	active site
1415784003401	motif I; other site
1415784003402	motif II; other site
1415784003403	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1415784003404	hypothetical protein; Provisional; Region: PRK13667
1415784003405	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1415784003406	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1415784003407	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1415784003408	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1415784003409	TrkA-N domain; Region: TrkA_N; pfam02254
1415784003410	TrkA-C domain; Region: TrkA_C; pfam02080
1415784003411	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
1415784003412	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1415784003413	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
1415784003414	metal binding site [ion binding]; metal-binding site
1415784003415	putative dimer interface [polypeptide binding]; other site
1415784003416	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
1415784003417	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
1415784003418	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
1415784003419	active site
1415784003420	trimer interface [polypeptide binding]; other site
1415784003421	substrate binding site [chemical binding]; other site
1415784003422	CoA binding site [chemical binding]; other site
1415784003423	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1415784003424	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1415784003425	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1415784003426	dimerization interface [polypeptide binding]; other site
1415784003427	FOG: CBS domain [General function prediction only]; Region: COG0517
1415784003428	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
1415784003429	Antirepressor AbbA; Region: AbbA_antirepres; pfam14156
1415784003430	Protein of unknown function (DUF458); Region: DUF458; pfam04308
1415784003431	Protein of unknown function (DUF1797); Region: DUF1797; pfam08796
1415784003432	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1415784003433	catalytic residues [active]
1415784003434	Protein of unknown function (DUF3993); Region: DUF3993; pfam13158
1415784003435	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1415784003436	EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388
1415784003437	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
1415784003438	short chain dehydrogenase; Provisional; Region: PRK07677
1415784003439	NAD(P) binding site [chemical binding]; other site
1415784003440	substrate binding site [chemical binding]; other site
1415784003441	homotetramer interface [polypeptide binding]; other site
1415784003442	active site
1415784003443	homodimer interface [polypeptide binding]; other site
1415784003444	phosphodiesterase YaeI; Provisional; Region: PRK11340
1415784003445	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1415784003446	putative active site [active]
1415784003447	putative metal binding site [ion binding]; other site
1415784003448	polyphosphate kinase; Provisional; Region: PRK05443
1415784003449	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
1415784003450	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
1415784003451	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
1415784003452	putative domain interface [polypeptide binding]; other site
1415784003453	putative active site [active]
1415784003454	catalytic site [active]
1415784003455	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
1415784003456	putative domain interface [polypeptide binding]; other site
1415784003457	putative active site [active]
1415784003458	catalytic site [active]
1415784003459	exopolyphosphatase; Region: exo_poly_only; TIGR03706
1415784003460	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1415784003461	nucleotide binding site [chemical binding]; other site
1415784003462	YkyB-like protein; Region: YkyB; pfam14177
1415784003463	Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368
1415784003464	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
1415784003465	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1415784003466	I-site; other site
1415784003467	active site
1415784003468	metal binding site [ion binding]; metal-binding site
1415784003469	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1415784003470	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784003471	putative substrate translocation pore; other site
1415784003472	Predicted transcriptional regulators [Transcription]; Region: COG1695
1415784003473	Transcriptional regulator PadR-like family; Region: PadR; cl17335
1415784003474	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
1415784003475	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
1415784003476	THF binding site; other site
1415784003477	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1415784003478	substrate binding site [chemical binding]; other site
1415784003479	THF binding site; other site
1415784003480	zinc-binding site [ion binding]; other site
1415784003481	Competence protein J (ComJ); Region: ComJ; pfam11033
1415784003482	Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040
1415784003483	Protein of unknown function (DUF3967); Region: DUF3967; pfam13152
1415784003484	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1415784003485	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1415784003486	dimer interface [polypeptide binding]; other site
1415784003487	phosphorylation site [posttranslational modification]
1415784003488	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784003489	ATP binding site [chemical binding]; other site
1415784003490	Mg2+ binding site [ion binding]; other site
1415784003491	G-X-G motif; other site
1415784003492	aminotransferase A; Validated; Region: PRK07683
1415784003493	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1415784003494	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784003495	homodimer interface [polypeptide binding]; other site
1415784003496	catalytic residue [active]
1415784003497	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1415784003498	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1415784003499	DNA binding site [nucleotide binding]
1415784003500	domain linker motif; other site
1415784003501	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
1415784003502	putative dimerization interface [polypeptide binding]; other site
1415784003503	putative ligand binding site [chemical binding]; other site
1415784003504	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1415784003505	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784003506	dimer interface [polypeptide binding]; other site
1415784003507	conserved gate region; other site
1415784003508	putative PBP binding loops; other site
1415784003509	ABC-ATPase subunit interface; other site
1415784003510	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1415784003511	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784003512	dimer interface [polypeptide binding]; other site
1415784003513	conserved gate region; other site
1415784003514	putative PBP binding loops; other site
1415784003515	ABC-ATPase subunit interface; other site
1415784003516	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
1415784003517	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1415784003518	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
1415784003519	homodimer interface [polypeptide binding]; other site
1415784003520	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
1415784003521	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1415784003522	active site
1415784003523	homodimer interface [polypeptide binding]; other site
1415784003524	catalytic site [active]
1415784003525	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1415784003526	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1415784003527	Ca binding site [ion binding]; other site
1415784003528	active site
1415784003529	catalytic site [active]
1415784003530	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1415784003531	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1415784003532	Walker A/P-loop; other site
1415784003533	ATP binding site [chemical binding]; other site
1415784003534	Q-loop/lid; other site
1415784003535	ABC transporter signature motif; other site
1415784003536	Walker B; other site
1415784003537	D-loop; other site
1415784003538	H-loop/switch region; other site
1415784003539	TOBE domain; Region: TOBE_2; pfam08402
1415784003540	hypothetical protein; Provisional; Region: PRK06720
1415784003541	NAD(P) binding site [chemical binding]; other site
1415784003542	RDD family; Region: RDD; pfam06271
1415784003543	Protein of unknown function (DUF3997); Region: DUF3997; pfam13162
1415784003544	Domain of unknown function (DUF4184); Region: DUF4184; pfam13803
1415784003545	Predicted ATPase [General function prediction only]; Region: COG3910
1415784003546	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1415784003547	Walker A/P-loop; other site
1415784003548	ATP binding site [chemical binding]; other site
1415784003549	Q-loop/lid; other site
1415784003550	ABC transporter signature motif; other site
1415784003551	Walker B; other site
1415784003552	D-loop; other site
1415784003553	H-loop/switch region; other site
1415784003554	putative acyltransferase; Provisional; Region: PRK05790
1415784003555	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1415784003556	dimer interface [polypeptide binding]; other site
1415784003557	active site
1415784003558	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
1415784003559	nudix motif; other site
1415784003560	Protein of unknown function (DUF3928); Region: DUF3928; pfam13065
1415784003561	hypothetical protein; Validated; Region: PRK07668
1415784003562	hypothetical protein; Validated; Region: PRK07668
1415784003563	Predicted transcriptional regulators [Transcription]; Region: COG1695
1415784003564	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1415784003565	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
1415784003566	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1415784003567	NAD(P) binding site [chemical binding]; other site
1415784003568	active site
1415784003569	YvrJ protein family; Region: YvrJ; pfam12841
1415784003570	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
1415784003571	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
1415784003572	methylthioribose kinase; Reviewed; Region: mtnK; PRK09550
1415784003573	Phosphotransferase enzyme family; Region: APH; pfam01636
1415784003574	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1415784003575	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
1415784003576	putative active site [active]
1415784003577	catalytic triad [active]
1415784003578	putative dimer interface [polypeptide binding]; other site
1415784003579	transaminase; Reviewed; Region: PRK08068
1415784003580	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1415784003581	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784003582	homodimer interface [polypeptide binding]; other site
1415784003583	catalytic residue [active]
1415784003584	2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549
1415784003585	2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209
1415784003586	dimer interface [polypeptide binding]; other site
1415784003587	active site
1415784003588	catalytic residue [active]
1415784003589	metal binding site [ion binding]; metal-binding site
1415784003590	2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase; Reviewed; Region: mtnX; PRK09552
1415784003591	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
1415784003592	methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754
1415784003593	intersubunit interface [polypeptide binding]; other site
1415784003594	active site
1415784003595	Zn2+ binding site [ion binding]; other site
1415784003596	ARD/ARD' family; Region: ARD; pfam03079
1415784003597	Cupin domain; Region: Cupin_2; pfam07883
1415784003598	Protein of unknown function (DUF3909); Region: DUF3909; pfam13077
1415784003599	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1415784003600	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1415784003601	Beta-lactamase; Region: Beta-lactamase; pfam00144
1415784003602	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1415784003603	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1415784003604	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1415784003605	metal binding site [ion binding]; metal-binding site
1415784003606	active site
1415784003607	I-site; other site
1415784003608	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
1415784003609	dimer interface [polypeptide binding]; other site
1415784003610	FMN binding site [chemical binding]; other site
1415784003611	Protein of unknown function (DUF3915); Region: DUF3915; pfam13054
1415784003612	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1415784003613	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1415784003614	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1415784003615	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1415784003616	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1415784003617	dimerization domain swap beta strand [polypeptide binding]; other site
1415784003618	regulatory protein interface [polypeptide binding]; other site
1415784003619	active site
1415784003620	regulatory phosphorylation site [posttranslational modification]; other site
1415784003621	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1415784003622	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
1415784003623	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1415784003624	active site turn [active]
1415784003625	phosphorylation site [posttranslational modification]
1415784003626	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1415784003627	HPr interaction site; other site
1415784003628	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1415784003629	active site
1415784003630	phosphorylation site [posttranslational modification]
1415784003631	transcriptional antiterminator BglG; Provisional; Region: PRK09772
1415784003632	CAT RNA binding domain; Region: CAT_RBD; smart01061
1415784003633	PRD domain; Region: PRD; pfam00874
1415784003634	PRD domain; Region: PRD; pfam00874
1415784003635	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1415784003636	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1415784003637	active site
1415784003638	motif I; other site
1415784003639	motif II; other site
1415784003640	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1415784003641	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1415784003642	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1415784003643	DNA-binding site [nucleotide binding]; DNA binding site
1415784003644	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1415784003645	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1415784003646	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
1415784003647	active site
1415784003648	trimer interface [polypeptide binding]; other site
1415784003649	allosteric site; other site
1415784003650	active site lid [active]
1415784003651	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1415784003652	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1415784003653	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1415784003654	active site
1415784003655	dimer interface [polypeptide binding]; other site
1415784003656	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
1415784003657	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1415784003658	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
1415784003659	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
1415784003660	Domain of unknown function (DUF309); Region: DUF309; pfam03745
1415784003661	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784003662	Coenzyme A binding pocket [chemical binding]; other site
1415784003663	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1415784003664	active site
1415784003665	Predicted secreted protein [Function unknown]; Region: COG4086
1415784003666	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
1415784003667	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1415784003668	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1415784003669	active site
1415784003670	motif I; other site
1415784003671	motif II; other site
1415784003672	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1415784003673	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1415784003674	Stage V sporulation protein AE1; Region: SpoVAE; pfam14097
1415784003675	stage V sporulation protein AE; Region: spore_V_AE; TIGR02839
1415784003676	stage V sporulation protein AD; Validated; Region: PRK08304
1415784003677	stage V sporulation protein AD; Provisional; Region: PRK12404
1415784003678	stage V sporulation protein AC; Region: spore_V_AC; TIGR02838
1415784003679	Stage V sporulation protein AB; Region: SpoVAB; pfam13782
1415784003680	Stage V sporulation protein AA; Region: SporV_AA; pfam12164
1415784003681	uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334
1415784003682	Na2 binding site [ion binding]; other site
1415784003683	putative substrate binding site 1 [chemical binding]; other site
1415784003684	Na binding site 1 [ion binding]; other site
1415784003685	putative substrate binding site 2 [chemical binding]; other site
1415784003686	sporulation sigma factor SigF; Validated; Region: PRK05572
1415784003687	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1415784003688	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1415784003689	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1415784003690	DNA binding residues [nucleotide binding]
1415784003691	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
1415784003692	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784003693	ATP binding site [chemical binding]; other site
1415784003694	Mg2+ binding site [ion binding]; other site
1415784003695	G-X-G motif; other site
1415784003696	anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886
1415784003697	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
1415784003698	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1415784003699	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1415784003700	Predicted transcriptional regulators [Transcription]; Region: COG1725
1415784003701	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1415784003702	DNA-binding site [nucleotide binding]; DNA binding site
1415784003703	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1415784003704	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1415784003705	Walker A/P-loop; other site
1415784003706	ATP binding site [chemical binding]; other site
1415784003707	Q-loop/lid; other site
1415784003708	ABC transporter signature motif; other site
1415784003709	Walker B; other site
1415784003710	D-loop; other site
1415784003711	H-loop/switch region; other site
1415784003712	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1415784003713	MarR family; Region: MarR; pfam01047
1415784003714	MarR family; Region: MarR_2; cl17246
1415784003715	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
1415784003716	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1415784003717	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1415784003718	Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831
1415784003719	oligomer interface [polypeptide binding]; other site
1415784003720	metal binding site [ion binding]; metal-binding site
1415784003721	metal binding site [ion binding]; metal-binding site
1415784003722	putative Cl binding site [ion binding]; other site
1415784003723	aspartate ring; other site
1415784003724	basic sphincter; other site
1415784003725	hydrophobic gate; other site
1415784003726	periplasmic entrance; other site
1415784003727	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
1415784003728	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1415784003729	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1415784003730	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
1415784003731	purine nucleoside phosphorylase; Provisional; Region: PRK08202
1415784003732	phosphopentomutase; Provisional; Region: PRK05362
1415784003733	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
1415784003734	YtkA-like; Region: YtkA; pfam13115
1415784003735	YtkA-like; Region: YtkA; pfam13115
1415784003736	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1415784003737	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1415784003738	active site
1415784003739	Int/Topo IB signature motif; other site
1415784003740	Protein of unknown function (DUF4227); Region: DUF4227; pfam14004
1415784003741	ferric uptake regulator; Provisional; Region: fur; PRK09462
1415784003742	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1415784003743	metal binding site 2 [ion binding]; metal-binding site
1415784003744	putative DNA binding helix; other site
1415784003745	metal binding site 1 [ion binding]; metal-binding site
1415784003746	dimer interface [polypeptide binding]; other site
1415784003747	structural Zn2+ binding site [ion binding]; other site
1415784003748	stage II sporulation protein M; Region: spo_II_M; TIGR02831
1415784003749	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1415784003750	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1415784003751	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
1415784003752	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1415784003753	dimer interface [polypeptide binding]; other site
1415784003754	ADP-ribose binding site [chemical binding]; other site
1415784003755	active site
1415784003756	nudix motif; other site
1415784003757	metal binding site [ion binding]; metal-binding site
1415784003758	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1415784003759	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1415784003760	active site
1415784003761	catalytic tetrad [active]
1415784003762	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1415784003763	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1415784003764	active site
1415784003765	catalytic tetrad [active]
1415784003766	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
1415784003767	Protein of unknown function (DUF3886); Region: DUF3886; pfam13025
1415784003768	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1415784003769	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
1415784003770	putative active site [active]
1415784003771	putative metal binding site [ion binding]; other site
1415784003772	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1415784003773	Ribbon-helix-helix domain; Region: RHH_3; pfam12651
1415784003774	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1415784003775	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1415784003776	Predicted permease [General function prediction only]; Region: COG2056
1415784003777	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
1415784003778	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
1415784003779	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1415784003780	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1415784003781	DNA binding site [nucleotide binding]
1415784003782	domain linker motif; other site
1415784003783	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1415784003784	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784003785	Coenzyme A binding pocket [chemical binding]; other site
1415784003786	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1415784003787	Protein of unknown function (DUF2552); Region: DUF2552; pfam10827
1415784003788	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
1415784003789	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
1415784003790	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1415784003791	catalytic motif [active]
1415784003792	Zn binding site [ion binding]; other site
1415784003793	RibD C-terminal domain; Region: RibD_C; cl17279
1415784003794	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1415784003795	Lumazine binding domain; Region: Lum_binding; pfam00677
1415784003796	Lumazine binding domain; Region: Lum_binding; pfam00677
1415784003797	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
1415784003798	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1415784003799	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1415784003800	dimerization interface [polypeptide binding]; other site
1415784003801	active site
1415784003802	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1415784003803	homopentamer interface [polypeptide binding]; other site
1415784003804	active site
1415784003805	biotin synthase; Validated; Region: PRK06256
1415784003806	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1415784003807	FeS/SAM binding site; other site
1415784003808	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
1415784003809	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
1415784003810	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784003811	S-adenosylmethionine binding site [chemical binding]; other site
1415784003812	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
1415784003813	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1415784003814	nucleophilic elbow; other site
1415784003815	catalytic triad; other site
1415784003816	putative hydrolase; Provisional; Region: PRK11460
1415784003817	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1415784003818	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1415784003819	substrate-cofactor binding pocket; other site
1415784003820	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784003821	catalytic residue [active]
1415784003822	AAA domain; Region: AAA_26; pfam13500
1415784003823	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
1415784003824	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916
1415784003825	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1415784003826	inhibitor-cofactor binding pocket; inhibition site
1415784003827	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784003828	catalytic residue [active]
1415784003829	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1415784003830	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
1415784003831	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
1415784003832	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
1415784003833	active site
1415784003834	metal binding site [ion binding]; metal-binding site
1415784003835	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1415784003836	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1415784003837	active site
1415784003838	catalytic triad [active]
1415784003839	oxyanion hole [active]
1415784003840	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1415784003841	dimerization interface [polypeptide binding]; other site
1415784003842	putative DNA binding site [nucleotide binding]; other site
1415784003843	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1415784003844	putative Zn2+ binding site [ion binding]; other site
1415784003845	ornithine carbamoyltransferase; Provisional; Region: PRK00779
1415784003846	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1415784003847	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1415784003848	acetylornithine aminotransferase; Provisional; Region: argD; PRK02936
1415784003849	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1415784003850	inhibitor-cofactor binding pocket; inhibition site
1415784003851	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784003852	catalytic residue [active]
1415784003853	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
1415784003854	nucleotide binding site [chemical binding]; other site
1415784003855	N-acetyl-L-glutamate binding site [chemical binding]; other site
1415784003856	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1415784003857	heterotetramer interface [polypeptide binding]; other site
1415784003858	active site pocket [active]
1415784003859	cleavage site
1415784003860	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
1415784003861	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1415784003862	YqzH-like protein; Region: YqzH; pfam14164
1415784003863	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1415784003864	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1415784003865	NAD(P) binding site [chemical binding]; other site
1415784003866	active site
1415784003867	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1415784003868	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1415784003869	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07679
1415784003870	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
1415784003871	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
1415784003872	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
1415784003873	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
1415784003874	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1415784003875	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
1415784003876	putative L-serine binding site [chemical binding]; other site
1415784003877	ribonuclease Z; Region: RNase_Z; TIGR02651
1415784003878	Protein of unknown function (DUF3932); Region: DUF3932; pfam13068
1415784003879	magnesium-transporting ATPase; Provisional; Region: PRK15122
1415784003880	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
1415784003881	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1415784003882	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1415784003883	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1415784003884	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1415784003885	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
1415784003886	MgtC family; Region: MgtC; pfam02308
1415784003887	DNA polymerase IV; Validated; Region: PRK01810
1415784003888	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1415784003889	active site
1415784003890	DNA binding site [nucleotide binding]
1415784003891	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
1415784003892	M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683
1415784003893	peptidase T-like protein; Region: PepT-like; TIGR01883
1415784003894	metal binding site [ion binding]; metal-binding site
1415784003895	putative dimer interface [polypeptide binding]; other site
1415784003896	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1415784003897	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1415784003898	Protein of unknown function (DUF3894); Region: DUF3894; pfam13033
1415784003899	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1415784003900	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1415784003901	Predicted membrane protein [Function unknown]; Region: COG4129
1415784003902	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1415784003903	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
1415784003904	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1415784003905	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1415784003906	Walker A/P-loop; other site
1415784003907	ATP binding site [chemical binding]; other site
1415784003908	Q-loop/lid; other site
1415784003909	ABC transporter signature motif; other site
1415784003910	Walker B; other site
1415784003911	D-loop; other site
1415784003912	H-loop/switch region; other site
1415784003913	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784003914	dimer interface [polypeptide binding]; other site
1415784003915	conserved gate region; other site
1415784003916	putative PBP binding loops; other site
1415784003917	ABC-ATPase subunit interface; other site
1415784003918	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1415784003919	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1415784003920	substrate binding pocket [chemical binding]; other site
1415784003921	membrane-bound complex binding site; other site
1415784003922	hinge residues; other site
1415784003923	Disulphide isomerase; Region: Disulph_isomer; pfam06491
1415784003924	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
1415784003925	nudix motif; other site
1415784003926	Predicted membrane protein [Function unknown]; Region: COG2323
1415784003927	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
1415784003928	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1415784003929	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1415784003930	E3 interaction surface; other site
1415784003931	lipoyl attachment site [posttranslational modification]; other site
1415784003932	e3 binding domain; Region: E3_binding; pfam02817
1415784003933	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1415784003934	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1415784003935	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1415784003936	alpha subunit interface [polypeptide binding]; other site
1415784003937	TPP binding site [chemical binding]; other site
1415784003938	heterodimer interface [polypeptide binding]; other site
1415784003939	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1415784003940	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
1415784003941	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1415784003942	tetramer interface [polypeptide binding]; other site
1415784003943	TPP-binding site [chemical binding]; other site
1415784003944	heterodimer interface [polypeptide binding]; other site
1415784003945	phosphorylation loop region [posttranslational modification]
1415784003946	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
1415784003947	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1415784003948	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1415784003949	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1415784003950	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1415784003951	nucleotide binding site [chemical binding]; other site
1415784003952	Acetokinase family; Region: Acetate_kinase; cl17229
1415784003953	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1415784003954	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1415784003955	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
1415784003956	NAD binding site [chemical binding]; other site
1415784003957	Phe binding site; other site
1415784003958	phosphate butyryltransferase; Validated; Region: PRK07742
1415784003959	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1415784003960	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
1415784003961	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1415784003962	putative active site [active]
1415784003963	heme pocket [chemical binding]; other site
1415784003964	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1415784003965	putative active site [active]
1415784003966	heme pocket [chemical binding]; other site
1415784003967	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1415784003968	Walker A motif; other site
1415784003969	ATP binding site [chemical binding]; other site
1415784003970	Walker B motif; other site
1415784003971	arginine finger; other site
1415784003972	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1415784003973	Protein of unknown function (DUF2627); Region: DUF2627; pfam11118
1415784003974	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1415784003975	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
1415784003976	active site
1415784003977	catalytic site [active]
1415784003978	metal binding site [ion binding]; metal-binding site
1415784003979	dimer interface [polypeptide binding]; other site
1415784003980	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1415784003981	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1415784003982	DXD motif; other site
1415784003983	Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913
1415784003984	sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875
1415784003985	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784003986	active site
1415784003987	phosphorylation site [posttranslational modification]
1415784003988	intermolecular recognition site; other site
1415784003989	dimerization interface [polypeptide binding]; other site
1415784003990	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
1415784003991	stage IV sporulation protein B; Region: spore_IV_B; TIGR02860
1415784003992	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1415784003993	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
1415784003994	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1415784003995	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1415784003996	Walker A/P-loop; other site
1415784003997	ATP binding site [chemical binding]; other site
1415784003998	Q-loop/lid; other site
1415784003999	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1415784004000	ABC transporter signature motif; other site
1415784004001	Walker B; other site
1415784004002	D-loop; other site
1415784004003	H-loop/switch region; other site
1415784004004	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1415784004005	arginine repressor; Provisional; Region: PRK04280
1415784004006	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1415784004007	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
1415784004008	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1415784004009	RNA binding surface [nucleotide binding]; other site
1415784004010	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
1415784004011	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
1415784004012	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1415784004013	TPP-binding site; other site
1415784004014	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1415784004015	PYR/PP interface [polypeptide binding]; other site
1415784004016	dimer interface [polypeptide binding]; other site
1415784004017	TPP binding site [chemical binding]; other site
1415784004018	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1415784004019	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1415784004020	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1415784004021	substrate binding pocket [chemical binding]; other site
1415784004022	chain length determination region; other site
1415784004023	substrate-Mg2+ binding site; other site
1415784004024	catalytic residues [active]
1415784004025	aspartate-rich region 1; other site
1415784004026	active site lid residues [active]
1415784004027	aspartate-rich region 2; other site
1415784004028	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063
1415784004029	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1415784004030	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1415784004031	generic binding surface II; other site
1415784004032	generic binding surface I; other site
1415784004033	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190
1415784004034	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1415784004035	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1415784004036	homodimer interface [polypeptide binding]; other site
1415784004037	NADP binding site [chemical binding]; other site
1415784004038	substrate binding site [chemical binding]; other site
1415784004039	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
1415784004040	putative RNA binding site [nucleotide binding]; other site
1415784004041	Asp23 family; Region: Asp23; pfam03780
1415784004042	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1415784004043	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1415784004044	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1415784004045	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1415784004046	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1415784004047	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1415784004048	carboxyltransferase (CT) interaction site; other site
1415784004049	biotinylation site [posttranslational modification]; other site
1415784004050	SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685
1415784004051	stage III sporulation protein AG; Region: spore_III_AG; TIGR02830
1415784004052	Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581
1415784004053	stage III sporulation protein AE; Region: spore_III_AE; TIGR02829
1415784004054	stage III sporulation protein AD; Region: spore_III_AD; TIGR02849
1415784004055	stage III sporulation protein AC; Region: spore_III_AC; TIGR02848
1415784004056	stage III sporulation protein SpoAB; Provisional; Region: PRK08307
1415784004057	stage III sporulation protein AA; Region: spore_III_AA; TIGR02858
1415784004058	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1415784004059	Walker A motif; other site
1415784004060	ATP binding site [chemical binding]; other site
1415784004061	Walker B motif; other site
1415784004062	Protein of unknown function (DUF2619); Region: DUF2619; pfam10942
1415784004063	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1415784004064	elongation factor P; Validated; Region: PRK00529
1415784004065	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1415784004066	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1415784004067	RNA binding site [nucleotide binding]; other site
1415784004068	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1415784004069	RNA binding site [nucleotide binding]; other site
1415784004070	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1415784004071	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1415784004072	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1415784004073	active site
1415784004074	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1415784004075	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1415784004076	trimer interface [polypeptide binding]; other site
1415784004077	active site
1415784004078	dimer interface [polypeptide binding]; other site
1415784004079	Conserved membrane protein YqhR; Region: YqhR; pfam11085
1415784004080	Protein of unknown function (DUF1385); Region: DUF1385; cl01595
1415784004081	Protein of unknown function (DUF1385); Region: DUF1385; cl01595
1415784004082	Carbon starvation protein CstA; Region: CstA; pfam02554
1415784004083	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1415784004084	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1415784004085	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1415784004086	motif II; other site
1415784004087	manganese transport transcriptional regulator; Provisional; Region: PRK03902
1415784004088	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1415784004089	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1415784004090	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
1415784004091	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1415784004092	FeS/SAM binding site; other site
1415784004093	Predicted transcriptional regulators [Transcription]; Region: COG1695
1415784004094	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1415784004095	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1415784004096	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1415784004097	active site residue [active]
1415784004098	coronin; Provisional; Region: PTZ00420
1415784004099	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1415784004100	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1415784004101	DNA binding site [nucleotide binding]
1415784004102	domain linker motif; other site
1415784004103	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
1415784004104	putative dimerization interface [polypeptide binding]; other site
1415784004105	putative ligand binding site [chemical binding]; other site
1415784004106	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1415784004107	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1415784004108	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1415784004109	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1415784004110	Protein of unknown function (DUF3975); Region: DUF3975; pfam13126
1415784004111	Domain of unknown function (DUF202); Region: DUF202; cl09954
1415784004112	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
1415784004113	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
1415784004114	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
1415784004115	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1415784004116	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1415784004117	Walker A/P-loop; other site
1415784004118	ATP binding site [chemical binding]; other site
1415784004119	Q-loop/lid; other site
1415784004120	ABC transporter signature motif; other site
1415784004121	Walker B; other site
1415784004122	D-loop; other site
1415784004123	H-loop/switch region; other site
1415784004124	Predicted transcriptional regulators [Transcription]; Region: COG1725
1415784004125	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1415784004126	DNA-binding site [nucleotide binding]; DNA binding site
1415784004127	Protein of unknown function (DUF3929); Region: DUF3929; pfam13066
1415784004128	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1415784004129	tetramer interface [polypeptide binding]; other site
1415784004130	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784004131	catalytic residue [active]
1415784004132	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
1415784004133	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1415784004134	tetramer interface [polypeptide binding]; other site
1415784004135	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784004136	catalytic residue [active]
1415784004137	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
1415784004138	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
1415784004139	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1415784004140	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1415784004141	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1415784004142	ATP binding site [chemical binding]; other site
1415784004143	putative Mg++ binding site [ion binding]; other site
1415784004144	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1415784004145	nucleotide binding region [chemical binding]; other site
1415784004146	ATP-binding site [chemical binding]; other site
1415784004147	Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079
1415784004148	YqzE-like protein; Region: YqzE; pfam14038
1415784004149	shikimate kinase; Reviewed; Region: aroK; PRK00131
1415784004150	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1415784004151	ADP binding site [chemical binding]; other site
1415784004152	magnesium binding site [ion binding]; other site
1415784004153	putative shikimate binding site; other site
1415784004154	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
1415784004155	ComG operon protein 7; Region: ComGG; pfam14173
1415784004156	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
1415784004157	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
1415784004158	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1415784004159	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1415784004160	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1415784004161	Walker A motif; other site
1415784004162	ATP binding site [chemical binding]; other site
1415784004163	Walker B motif; other site
1415784004164	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1415784004165	putative DNA binding site [nucleotide binding]; other site
1415784004166	iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702
1415784004167	putative Zn2+ binding site [ion binding]; other site
1415784004168	Protein of unknown function (DUF2626); Region: DUF2626; pfam11117
1415784004169	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
1415784004170	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1415784004171	Protein of unknown function (DUF3912); Region: DUF3912; pfam13051
1415784004172	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818
1415784004173	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1415784004174	Protein of unknown function (DUF3966); Region: DUF3966; pfam13110
1415784004175	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446
1415784004176	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1415784004177	active site
1415784004178	homodimer interface [polypeptide binding]; other site
1415784004179	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
1415784004180	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
1415784004181	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
1415784004182	substrate binding pocket [chemical binding]; other site
1415784004183	dimer interface [polypeptide binding]; other site
1415784004184	inhibitor binding site; inhibition site
1415784004185	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
1415784004186	B12 binding site [chemical binding]; other site
1415784004187	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
1415784004188	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
1415784004189	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
1415784004190	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1415784004191	FAD binding site [chemical binding]; other site
1415784004192	cystathionine gamma-synthase; Reviewed; Region: PRK08247
1415784004193	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1415784004194	homodimer interface [polypeptide binding]; other site
1415784004195	substrate-cofactor binding pocket; other site
1415784004196	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784004197	catalytic residue [active]
1415784004198	cystathionine beta-lyase; Provisional; Region: PRK08064
1415784004199	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1415784004200	homodimer interface [polypeptide binding]; other site
1415784004201	substrate-cofactor binding pocket; other site
1415784004202	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784004203	catalytic residue [active]
1415784004204	Isochorismatase family; Region: Isochorismatase; pfam00857
1415784004205	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
1415784004206	catalytic triad [active]
1415784004207	conserved cis-peptide bond; other site
1415784004208	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1415784004209	dimerization interface [polypeptide binding]; other site
1415784004210	putative DNA binding site [nucleotide binding]; other site
1415784004211	putative Zn2+ binding site [ion binding]; other site
1415784004212	Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636
1415784004213	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1415784004214	Protein of unknown function (DUF2759); Region: DUF2759; pfam10958
1415784004215	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
1415784004216	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1415784004217	nucleotide binding site [chemical binding]; other site
1415784004218	Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014
1415784004219	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
1415784004220	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1415784004221	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1415784004222	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
1415784004223	active site
1415784004224	Substrate binding site; other site
1415784004225	Mg++ binding site; other site
1415784004226	putative trimer interface [polypeptide binding]; other site
1415784004227	Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132
1415784004228	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1415784004229	putative CoA binding site [chemical binding]; other site
1415784004230	putative trimer interface [polypeptide binding]; other site
1415784004231	putative CoA binding site [chemical binding]; other site
1415784004232	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
1415784004233	active site
1415784004234	metal binding site [ion binding]; metal-binding site
1415784004235	substrate binding site [chemical binding]; other site
1415784004236	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1415784004237	PhoU domain; Region: PhoU; pfam01895
1415784004238	PhoU domain; Region: PhoU; pfam01895
1415784004239	phosphate transporter ATP-binding protein; Provisional; Region: PRK14238
1415784004240	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1415784004241	Walker A/P-loop; other site
1415784004242	ATP binding site [chemical binding]; other site
1415784004243	Q-loop/lid; other site
1415784004244	ABC transporter signature motif; other site
1415784004245	Walker B; other site
1415784004246	D-loop; other site
1415784004247	H-loop/switch region; other site
1415784004248	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
1415784004249	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784004250	dimer interface [polypeptide binding]; other site
1415784004251	conserved gate region; other site
1415784004252	putative PBP binding loops; other site
1415784004253	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1415784004254	ABC-ATPase subunit interface; other site
1415784004255	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
1415784004256	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784004257	dimer interface [polypeptide binding]; other site
1415784004258	conserved gate region; other site
1415784004259	putative PBP binding loops; other site
1415784004260	ABC-ATPase subunit interface; other site
1415784004261	PBP superfamily domain; Region: PBP_like_2; cl17296
1415784004262	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1415784004263	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1415784004264	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1415784004265	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1415784004266	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784004267	putative substrate translocation pore; other site
1415784004268	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1415784004269	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1415784004270	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1415784004271	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1415784004272	Protein of unknown function (DUF1189); Region: DUF1189; pfam06691
1415784004273	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
1415784004274	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1415784004275	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1415784004276	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1415784004277	metal binding site 2 [ion binding]; metal-binding site
1415784004278	putative DNA binding helix; other site
1415784004279	metal binding site 1 [ion binding]; metal-binding site
1415784004280	dimer interface [polypeptide binding]; other site
1415784004281	structural Zn2+ binding site [ion binding]; other site
1415784004282	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1415784004283	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1415784004284	ABC-ATPase subunit  interface; other site
1415784004285	dimer interface [polypeptide binding]; other site
1415784004286	putative PBP binding regions; other site
1415784004287	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1415784004288	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1415784004289	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1415784004290	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1415784004291	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1415784004292	Protein of unknown function (DUF2624); Region: DUF2624; pfam11116
1415784004293	endonuclease IV; Provisional; Region: PRK01060
1415784004294	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
1415784004295	AP (apurinic/apyrimidinic) site pocket; other site
1415784004296	DNA interaction; other site
1415784004297	Metal-binding active site; metal-binding site
1415784004298	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1415784004299	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1415784004300	ATP binding site [chemical binding]; other site
1415784004301	Mg++ binding site [ion binding]; other site
1415784004302	motif III; other site
1415784004303	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1415784004304	nucleotide binding region [chemical binding]; other site
1415784004305	ATP-binding site [chemical binding]; other site
1415784004306	YqfQ-like protein; Region: YqfQ; pfam14181
1415784004307	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
1415784004308	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
1415784004309	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1415784004310	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1415784004311	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
1415784004312	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1415784004313	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1415784004314	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
1415784004315	Family of unknown function (DUF633); Region: DUF633; pfam04816
1415784004316	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1415784004317	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1415784004318	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
1415784004319	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1415784004320	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1415784004321	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1415784004322	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1415784004323	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1415784004324	DNA binding residues [nucleotide binding]
1415784004325	DNA primase; Validated; Region: dnaG; PRK05667
1415784004326	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1415784004327	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1415784004328	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1415784004329	active site
1415784004330	metal binding site [ion binding]; metal-binding site
1415784004331	interdomain interaction site; other site
1415784004332	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
1415784004333	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
1415784004334	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727
1415784004335	PEP synthetase regulatory protein; Provisional; Region: PRK05339
1415784004336	HTH domain; Region: HTH_11; cl17392
1415784004337	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
1415784004338	FOG: CBS domain [General function prediction only]; Region: COG0517
1415784004339	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
1415784004340	Recombination protein O N terminal; Region: RecO_N; pfam11967
1415784004341	Recombination protein O C terminal; Region: RecO_C; pfam02565
1415784004342	GTPase Era; Reviewed; Region: era; PRK00089
1415784004343	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1415784004344	G1 box; other site
1415784004345	GTP/Mg2+ binding site [chemical binding]; other site
1415784004346	Switch I region; other site
1415784004347	G2 box; other site
1415784004348	Switch II region; other site
1415784004349	G3 box; other site
1415784004350	G4 box; other site
1415784004351	G5 box; other site
1415784004352	KH domain; Region: KH_2; pfam07650
1415784004353	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1415784004354	active site
1415784004355	catalytic motif [active]
1415784004356	Zn binding site [ion binding]; other site
1415784004357	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
1415784004358	metal-binding heat shock protein; Provisional; Region: PRK00016
1415784004359	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
1415784004360	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
1415784004361	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1415784004362	Zn2+ binding site [ion binding]; other site
1415784004363	Mg2+ binding site [ion binding]; other site
1415784004364	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1415784004365	PhoH-like protein; Region: PhoH; pfam02562
1415784004366	Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898
1415784004367	sporulation protein YqfD; Region: spore_yqfD; TIGR02876
1415784004368	sporulation protein YqfC; Region: spore_yqfC; TIGR02856
1415784004369	Yqey-like protein; Region: YqeY; pfam09424
1415784004370	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1415784004371	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
1415784004372	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1415784004373	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1415784004374	FeS/SAM binding site; other site
1415784004375	TRAM domain; Region: TRAM; cl01282
1415784004376	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
1415784004377	RNA methyltransferase, RsmE family; Region: TIGR00046
1415784004378	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
1415784004379	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784004380	S-adenosylmethionine binding site [chemical binding]; other site
1415784004381	chaperone protein DnaJ; Provisional; Region: PRK14280
1415784004382	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1415784004383	HSP70 interaction site [polypeptide binding]; other site
1415784004384	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
1415784004385	substrate binding site [polypeptide binding]; other site
1415784004386	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1415784004387	Zn binding sites [ion binding]; other site
1415784004388	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1415784004389	dimer interface [polypeptide binding]; other site
1415784004390	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1415784004391	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
1415784004392	nucleotide binding site [chemical binding]; other site
1415784004393	NEF interaction site [polypeptide binding]; other site
1415784004394	SBD interface [polypeptide binding]; other site
1415784004395	heat shock protein GrpE; Provisional; Region: PRK14140
1415784004396	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1415784004397	dimer interface [polypeptide binding]; other site
1415784004398	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1415784004399	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
1415784004400	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
1415784004401	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
1415784004402	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1415784004403	FeS/SAM binding site; other site
1415784004404	HemN C-terminal domain; Region: HemN_C; pfam06969
1415784004405	Predicted transcriptional regulators [Transcription]; Region: COG1733
1415784004406	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1415784004407	GTP-binding protein LepA; Provisional; Region: PRK05433
1415784004408	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1415784004409	G1 box; other site
1415784004410	putative GEF interaction site [polypeptide binding]; other site
1415784004411	GTP/Mg2+ binding site [chemical binding]; other site
1415784004412	Switch I region; other site
1415784004413	G2 box; other site
1415784004414	G3 box; other site
1415784004415	Switch II region; other site
1415784004416	G4 box; other site
1415784004417	G5 box; other site
1415784004418	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1415784004419	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1415784004420	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1415784004421	Protein of unknown function (DUF3679); Region: DUF3679; pfam12438
1415784004422	germination protease; Provisional; Region: PRK02858
1415784004423	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1415784004424	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
1415784004425	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1415784004426	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
1415784004427	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
1415784004428	Competence protein; Region: Competence; pfam03772
1415784004429	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1415784004430	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
1415784004431	catalytic motif [active]
1415784004432	Zn binding site [ion binding]; other site
1415784004433	SLBB domain; Region: SLBB; pfam10531
1415784004434	comEA protein; Region: comE; TIGR01259
1415784004435	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
1415784004436	late competence protein ComER; Validated; Region: PRK07680
1415784004437	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1415784004438	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
1415784004439	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784004440	S-adenosylmethionine binding site [chemical binding]; other site
1415784004441	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cl07889
1415784004442	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
1415784004443	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1415784004444	Zn2+ binding site [ion binding]; other site
1415784004445	Mg2+ binding site [ion binding]; other site
1415784004446	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
1415784004447	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1415784004448	active site
1415784004449	(T/H)XGH motif; other site
1415784004450	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
1415784004451	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
1415784004452	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1415784004453	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1415784004454	shikimate binding site; other site
1415784004455	NAD(P) binding site [chemical binding]; other site
1415784004456	GTPase YqeH; Provisional; Region: PRK13796
1415784004457	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
1415784004458	GTP/Mg2+ binding site [chemical binding]; other site
1415784004459	G4 box; other site
1415784004460	G5 box; other site
1415784004461	G1 box; other site
1415784004462	Switch I region; other site
1415784004463	G2 box; other site
1415784004464	G3 box; other site
1415784004465	Switch II region; other site
1415784004466	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
1415784004467	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1415784004468	active site
1415784004469	motif I; other site
1415784004470	motif II; other site
1415784004471	Sporulation inhibitor A; Region: Sda; pfam08970
1415784004472	phosphatidylserine decarboxylase; Provisional; Region: PRK03140
1415784004473	sporulation sigma factor SigK; Reviewed; Region: PRK05803
1415784004474	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1415784004475	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1415784004476	DNA binding residues [nucleotide binding]
1415784004477	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1415784004478	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1415784004479	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
1415784004480	dimer interface [polypeptide binding]; other site
1415784004481	FMN binding site [chemical binding]; other site
1415784004482	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1415784004483	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1415784004484	synthetase active site [active]
1415784004485	NTP binding site [chemical binding]; other site
1415784004486	metal binding site [ion binding]; metal-binding site
1415784004487	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
1415784004488	dimer interface [polypeptide binding]; other site
1415784004489	Alkaline phosphatase homologues; Region: alkPPc; smart00098
1415784004490	active site
1415784004491	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1415784004492	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784004493	Coenzyme A binding pocket [chemical binding]; other site
1415784004494	Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342
1415784004495	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1415784004496	CHAT domain; Region: CHAT; cl17868
1415784004497	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
1415784004498	catalytic core [active]
1415784004499	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
1415784004500	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
1415784004501	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
1415784004502	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
1415784004503	putative active site [active]
1415784004504	catalytic triad [active]
1415784004505	PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133
1415784004506	putative integrin binding motif; other site
1415784004507	PA/protease domain interface [polypeptide binding]; other site
1415784004508	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
1415784004509	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
1415784004510	phenylalanine 4-monooxygenase; Provisional; Region: PRK14056
1415784004511	Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361
1415784004512	cofactor binding site; other site
1415784004513	metal binding site [ion binding]; metal-binding site
1415784004514	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
1415784004515	aromatic arch; other site
1415784004516	DCoH dimer interaction site [polypeptide binding]; other site
1415784004517	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
1415784004518	DCoH tetramer interaction site [polypeptide binding]; other site
1415784004519	substrate binding site [chemical binding]; other site
1415784004520	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
1415784004521	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
1415784004522	putative metal binding site [ion binding]; other site
1415784004523	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1415784004524	active site
1415784004525	Predicted membrane protein [Function unknown]; Region: COG2259
1415784004526	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
1415784004527	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1415784004528	non-specific DNA binding site [nucleotide binding]; other site
1415784004529	salt bridge; other site
1415784004530	sequence-specific DNA binding site [nucleotide binding]; other site
1415784004531	Cupin domain; Region: Cupin_2; pfam07883
1415784004532	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1415784004533	active site 2 [active]
1415784004534	active site 1 [active]
1415784004535	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784004536	Coenzyme A binding pocket [chemical binding]; other site
1415784004537	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1415784004538	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1415784004539	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1415784004540	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529
1415784004541	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1415784004542	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1415784004543	Walker A/P-loop; other site
1415784004544	ATP binding site [chemical binding]; other site
1415784004545	Q-loop/lid; other site
1415784004546	ABC transporter signature motif; other site
1415784004547	Walker B; other site
1415784004548	D-loop; other site
1415784004549	H-loop/switch region; other site
1415784004550	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1415784004551	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1415784004552	ABC-ATPase subunit  interface; other site
1415784004553	dimer interface [polypeptide binding]; other site
1415784004554	putative PBP binding regions; other site
1415784004555	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1415784004556	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1415784004557	intersubunit interface [polypeptide binding]; other site
1415784004558	YrhC-like protein; Region: YrhC; pfam14143
1415784004559	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
1415784004560	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
1415784004561	putative catalytic cysteine [active]
1415784004562	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
1415784004563	putative active site [active]
1415784004564	metal binding site [ion binding]; metal-binding site
1415784004565	cystathionine beta-lyase; Provisional; Region: PRK07671
1415784004566	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1415784004567	homodimer interface [polypeptide binding]; other site
1415784004568	substrate-cofactor binding pocket; other site
1415784004569	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784004570	catalytic residue [active]
1415784004571	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1415784004572	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1415784004573	dimer interface [polypeptide binding]; other site
1415784004574	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784004575	catalytic residue [active]
1415784004576	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
1415784004577	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
1415784004578	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1415784004579	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784004580	S-adenosylmethionine binding site [chemical binding]; other site
1415784004581	Protein of unknown function (DUF2536); Region: DUF2536; pfam10750
1415784004582	Protein of unknown function (DUF1510); Region: DUF1510; pfam07423
1415784004583	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1415784004584	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1415784004585	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1415784004586	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1415784004587	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1415784004588	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1415784004589	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
1415784004590	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
1415784004591	ATP-binding site [chemical binding]; other site
1415784004592	Sugar specificity; other site
1415784004593	Pyrimidine base specificity; other site
1415784004594	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1415784004595	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1415784004596	Peptidase family U32; Region: Peptidase_U32; pfam01136
1415784004597	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1415784004598	Protein of unknown function (DUF556); Region: DUF556; cl00822
1415784004599	Peptidase family U32; Region: Peptidase_U32; pfam01136
1415784004600	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1415784004601	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784004602	S-adenosylmethionine binding site [chemical binding]; other site
1415784004603	YceG-like family; Region: YceG; pfam02618
1415784004604	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1415784004605	dimerization interface [polypeptide binding]; other site
1415784004606	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
1415784004607	hypothetical protein; Provisional; Region: PRK05473
1415784004608	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1415784004609	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1415784004610	motif 1; other site
1415784004611	active site
1415784004612	motif 2; other site
1415784004613	motif 3; other site
1415784004614	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1415784004615	DHHA1 domain; Region: DHHA1; pfam02272
1415784004616	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1415784004617	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1415784004618	Family description; Region: UvrD_C_2; pfam13538
1415784004619	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
1415784004620	AAA domain; Region: AAA_30; pfam13604
1415784004621	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1415784004622	TPR motif; other site
1415784004623	TPR repeat; Region: TPR_11; pfam13414
1415784004624	binding surface
1415784004625	TPR repeat; Region: TPR_11; pfam13414
1415784004626	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1415784004627	binding surface
1415784004628	TPR motif; other site
1415784004629	TPR repeat; Region: TPR_11; pfam13414
1415784004630	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
1415784004631	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1415784004632	Ligand Binding Site [chemical binding]; other site
1415784004633	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1415784004634	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1415784004635	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1415784004636	catalytic residue [active]
1415784004637	Predicted transcriptional regulator [Transcription]; Region: COG1959
1415784004638	Transcriptional regulator; Region: Rrf2; pfam02082
1415784004639	recombination factor protein RarA; Reviewed; Region: PRK13342
1415784004640	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1415784004641	Walker A motif; other site
1415784004642	ATP binding site [chemical binding]; other site
1415784004643	Walker B motif; other site
1415784004644	arginine finger; other site
1415784004645	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1415784004646	putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923
1415784004647	transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894
1415784004648	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
1415784004649	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
1415784004650	putative ATP binding site [chemical binding]; other site
1415784004651	putative substrate interface [chemical binding]; other site
1415784004652	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1415784004653	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1415784004654	dimer interface [polypeptide binding]; other site
1415784004655	anticodon binding site; other site
1415784004656	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1415784004657	homodimer interface [polypeptide binding]; other site
1415784004658	motif 1; other site
1415784004659	active site
1415784004660	motif 2; other site
1415784004661	GAD domain; Region: GAD; pfam02938
1415784004662	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1415784004663	motif 3; other site
1415784004664	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1415784004665	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1415784004666	dimer interface [polypeptide binding]; other site
1415784004667	motif 1; other site
1415784004668	active site
1415784004669	motif 2; other site
1415784004670	motif 3; other site
1415784004671	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1415784004672	anticodon binding site; other site
1415784004673	Protein of unknown function (DUF2568); Region: DUF2568; pfam10823
1415784004674	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1415784004675	putative active site [active]
1415784004676	dimerization interface [polypeptide binding]; other site
1415784004677	putative tRNAtyr binding site [nucleotide binding]; other site
1415784004678	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1415784004679	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1415784004680	Zn2+ binding site [ion binding]; other site
1415784004681	Mg2+ binding site [ion binding]; other site
1415784004682	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1415784004683	synthetase active site [active]
1415784004684	NTP binding site [chemical binding]; other site
1415784004685	metal binding site [ion binding]; metal-binding site
1415784004686	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1415784004687	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1415784004688	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1415784004689	active site
1415784004690	Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141
1415784004691	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
1415784004692	DHH family; Region: DHH; pfam01368
1415784004693	DHHA1 domain; Region: DHHA1; pfam02272
1415784004694	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1415784004695	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
1415784004696	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
1415784004697	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
1415784004698	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
1415784004699	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
1415784004700	Protein export membrane protein; Region: SecD_SecF; pfam02355
1415784004701	Post-transcriptional regulator; Region: Post_transc_reg; pfam13797
1415784004702	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1415784004703	stage V sporulation protein B; Region: spore_V_B; TIGR02900
1415784004704	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1415784004705	Predicted membrane protein [Function unknown]; Region: COG2323
1415784004706	putative membrane protein, TIGR04086 family; Region: TIGR04086_membr
1415784004707	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
1415784004708	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1415784004709	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1415784004710	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1415784004711	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1415784004712	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
1415784004713	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1415784004714	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1415784004715	Walker A motif; other site
1415784004716	ATP binding site [chemical binding]; other site
1415784004717	Walker B motif; other site
1415784004718	arginine finger; other site
1415784004719	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1415784004720	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1415784004721	RuvA N terminal domain; Region: RuvA_N; pfam01330
1415784004722	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1415784004723	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1415784004724	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
1415784004725	putative ligand binding residues [chemical binding]; other site
1415784004726	Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977
1415784004727	BofC C-terminal domain; Region: BofC_C; pfam08955
1415784004728	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
1415784004729	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1415784004730	quinolinate synthetase; Provisional; Region: PRK09375
1415784004731	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072
1415784004732	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
1415784004733	dimerization interface [polypeptide binding]; other site
1415784004734	active site
1415784004735	L-aspartate oxidase; Provisional; Region: PRK08071
1415784004736	L-aspartate oxidase; Provisional; Region: PRK06175
1415784004737	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1415784004738	cysteine desulfurase; Provisional; Region: PRK02948
1415784004739	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1415784004740	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1415784004741	catalytic residue [active]
1415784004742	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
1415784004743	3H domain; Region: 3H; pfam02829
1415784004744	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
1415784004745	MOSC domain; Region: MOSC; pfam03473
1415784004746	3-alpha domain; Region: 3-alpha; pfam03475
1415784004747	prephenate dehydratase; Provisional; Region: PRK11898
1415784004748	Prephenate dehydratase; Region: PDT; pfam00800
1415784004749	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1415784004750	putative L-Phe binding site [chemical binding]; other site
1415784004751	FtsX-like permease family; Region: FtsX; pfam02687
1415784004752	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1415784004753	FtsX-like permease family; Region: FtsX; pfam02687
1415784004754	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1415784004755	FtsX-like permease family; Region: FtsX; pfam02687
1415784004756	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1415784004757	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1415784004758	Walker A/P-loop; other site
1415784004759	ATP binding site [chemical binding]; other site
1415784004760	Q-loop/lid; other site
1415784004761	ABC transporter signature motif; other site
1415784004762	Walker B; other site
1415784004763	D-loop; other site
1415784004764	H-loop/switch region; other site
1415784004765	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1415784004766	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1415784004767	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784004768	ATP binding site [chemical binding]; other site
1415784004769	Mg2+ binding site [ion binding]; other site
1415784004770	G-X-G motif; other site
1415784004771	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1415784004772	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784004773	active site
1415784004774	phosphorylation site [posttranslational modification]
1415784004775	intermolecular recognition site; other site
1415784004776	dimerization interface [polypeptide binding]; other site
1415784004777	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1415784004778	DNA binding site [nucleotide binding]
1415784004779	GTPase CgtA; Reviewed; Region: obgE; PRK12297
1415784004780	GTP1/OBG; Region: GTP1_OBG; pfam01018
1415784004781	Obg GTPase; Region: Obg; cd01898
1415784004782	G1 box; other site
1415784004783	GTP/Mg2+ binding site [chemical binding]; other site
1415784004784	Switch I region; other site
1415784004785	G2 box; other site
1415784004786	G3 box; other site
1415784004787	Switch II region; other site
1415784004788	G4 box; other site
1415784004789	G5 box; other site
1415784004790	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
1415784004791	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1415784004792	hypothetical protein; Provisional; Region: PRK14553
1415784004793	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1415784004794	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
1415784004795	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1415784004796	homodimer interface [polypeptide binding]; other site
1415784004797	oligonucleotide binding site [chemical binding]; other site
1415784004798	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161
1415784004799	Peptidase family M50; Region: Peptidase_M50; pfam02163
1415784004800	active site
1415784004801	putative substrate binding region [chemical binding]; other site
1415784004802	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1415784004803	Peptidase family M23; Region: Peptidase_M23; pfam01551
1415784004804	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
1415784004805	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
1415784004806	Switch I; other site
1415784004807	Switch II; other site
1415784004808	septum formation inhibitor; Reviewed; Region: minC; PRK00513
1415784004809	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
1415784004810	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
1415784004811	rod shape-determining protein MreC; Provisional; Region: PRK13922
1415784004812	rod shape-determining protein MreC; Region: MreC; pfam04085
1415784004813	rod shape-determining protein MreB; Provisional; Region: PRK13927
1415784004814	MreB and similar proteins; Region: MreB_like; cd10225
1415784004815	nucleotide binding site [chemical binding]; other site
1415784004816	Mg binding site [ion binding]; other site
1415784004817	putative protofilament interaction site [polypeptide binding]; other site
1415784004818	RodZ interaction site [polypeptide binding]; other site
1415784004819	hypothetical protein; Reviewed; Region: PRK00024
1415784004820	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1415784004821	MPN+ (JAMM) motif; other site
1415784004822	Zinc-binding site [ion binding]; other site
1415784004823	Maf-like protein; Region: Maf; pfam02545
1415784004824	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1415784004825	active site
1415784004826	dimer interface [polypeptide binding]; other site
1415784004827	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1415784004828	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1415784004829	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1415784004830	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1415784004831	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1415784004832	active site
1415784004833	HIGH motif; other site
1415784004834	nucleotide binding site [chemical binding]; other site
1415784004835	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1415784004836	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1415784004837	active site
1415784004838	KMSKS motif; other site
1415784004839	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1415784004840	tRNA binding surface [nucleotide binding]; other site
1415784004841	anticodon binding site; other site
1415784004842	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1415784004843	spore coat protein YsxE; Region: spore_ysxE; TIGR02904
1415784004844	spore coat protein, CotS family; Region: spore_CotS; TIGR02906
1415784004845	stage VI sporulation protein D; Region: spore_VI_D; TIGR02907
1415784004846	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1415784004847	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1415784004848	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1415784004849	inhibitor-cofactor binding pocket; inhibition site
1415784004850	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784004851	catalytic residue [active]
1415784004852	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
1415784004853	dimer interface [polypeptide binding]; other site
1415784004854	active site
1415784004855	Schiff base residues; other site
1415784004856	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
1415784004857	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1415784004858	active site
1415784004859	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1415784004860	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
1415784004861	domain interfaces; other site
1415784004862	active site
1415784004863	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
1415784004864	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
1415784004865	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
1415784004866	tRNA; other site
1415784004867	putative tRNA binding site [nucleotide binding]; other site
1415784004868	putative NADP binding site [chemical binding]; other site
1415784004869	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1415784004870	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1415784004871	MarR family; Region: MarR; pfam01047
1415784004872	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
1415784004873	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1415784004874	G1 box; other site
1415784004875	GTP/Mg2+ binding site [chemical binding]; other site
1415784004876	Switch I region; other site
1415784004877	G2 box; other site
1415784004878	G3 box; other site
1415784004879	Switch II region; other site
1415784004880	G4 box; other site
1415784004881	G5 box; other site
1415784004882	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
1415784004883	Found in ATP-dependent protease La (LON); Region: LON; smart00464
1415784004884	Found in ATP-dependent protease La (LON); Region: LON; smart00464
1415784004885	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1415784004886	Walker A motif; other site
1415784004887	ATP binding site [chemical binding]; other site
1415784004888	Walker B motif; other site
1415784004889	arginine finger; other site
1415784004890	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1415784004891	ATP-dependent protease LonB; Region: spore_lonB; TIGR02902
1415784004892	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1415784004893	Walker A motif; other site
1415784004894	ATP binding site [chemical binding]; other site
1415784004895	Walker B motif; other site
1415784004896	arginine finger; other site
1415784004897	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1415784004898	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1415784004899	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1415784004900	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1415784004901	Walker A motif; other site
1415784004902	ATP binding site [chemical binding]; other site
1415784004903	Walker B motif; other site
1415784004904	arginine finger; other site
1415784004905	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1415784004906	trigger factor; Provisional; Region: tig; PRK01490
1415784004907	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1415784004908	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1415784004909	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
1415784004910	pentamer interface [polypeptide binding]; other site
1415784004911	dodecaamer interface [polypeptide binding]; other site
1415784004912	YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724
1415784004913	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
1415784004914	active site
1415784004915	metal binding site [ion binding]; metal-binding site
1415784004916	homotetramer interface [polypeptide binding]; other site
1415784004917	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1415784004918	active site
1415784004919	dimerization interface [polypeptide binding]; other site
1415784004920	ribonuclease PH; Reviewed; Region: rph; PRK00173
1415784004921	Ribonuclease PH; Region: RNase_PH_bact; cd11362
1415784004922	hexamer interface [polypeptide binding]; other site
1415784004923	active site
1415784004924	Sporulation and spore germination; Region: Germane; pfam10646
1415784004925	Spore germination protein [General function prediction only]; Region: COG5401
1415784004926	Sporulation and spore germination; Region: Germane; pfam10646
1415784004927	glutamate racemase; Provisional; Region: PRK00865
1415784004928	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
1415784004929	intracellular protease, PfpI family; Region: PfpI; TIGR01382
1415784004930	potential catalytic triad [active]
1415784004931	conserved cys residue [active]
1415784004932	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1415784004933	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1415784004934	catalytic residues [active]
1415784004935	catalytic nucleophile [active]
1415784004936	Recombinase; Region: Recombinase; pfam07508
1415784004937	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1415784004938	Divergent AAA domain; Region: AAA_4; pfam04326
1415784004939	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1415784004940	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1415784004941	catalytic residues [active]
1415784004942	catalytic nucleophile [active]
1415784004943	Recombinase; Region: Recombinase; pfam07508
1415784004944	Protein of unknown function (DUF3450); Region: DUF3450; pfam11932
1415784004945	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1415784004946	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1415784004947	catalytic residues [active]
1415784004948	Recombinase; Region: Recombinase; pfam07508
1415784004949	Helix-turn-helix domain; Region: HTH_17; pfam12728
1415784004950	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1415784004951	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1415784004952	non-specific DNA binding site [nucleotide binding]; other site
1415784004953	salt bridge; other site
1415784004954	sequence-specific DNA binding site [nucleotide binding]; other site
1415784004955	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
1415784004956	SIR2-like domain; Region: SIR2_2; pfam13289
1415784004957	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1415784004958	binding surface
1415784004959	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1415784004960	TPR motif; other site
1415784004961	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1415784004962	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1415784004963	DNA binding residues [nucleotide binding]
1415784004964	putative uracil/xanthine transporter; Provisional; Region: PRK11412
1415784004965	putative deaminase; Validated; Region: PRK06846
1415784004966	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
1415784004967	active site
1415784004968	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
1415784004969	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
1415784004970	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1415784004971	non-specific DNA binding site [nucleotide binding]; other site
1415784004972	salt bridge; other site
1415784004973	sequence-specific DNA binding site [nucleotide binding]; other site
1415784004974	Cupin domain; Region: Cupin_2; pfam07883
1415784004975	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
1415784004976	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
1415784004977	amphipathic channel; other site
1415784004978	Asn-Pro-Ala signature motifs; other site
1415784004979	Predicted transcriptional regulator [Transcription]; Region: COG1959
1415784004980	Transcriptional regulator; Region: Rrf2; pfam02082
1415784004981	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
1415784004982	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
1415784004983	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1415784004984	Walker A/P-loop; other site
1415784004985	ATP binding site [chemical binding]; other site
1415784004986	Q-loop/lid; other site
1415784004987	ABC transporter signature motif; other site
1415784004988	Walker B; other site
1415784004989	D-loop; other site
1415784004990	H-loop/switch region; other site
1415784004991	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
1415784004992	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1415784004993	active site
1415784004994	motif I; other site
1415784004995	motif II; other site
1415784004996	flagellar motor protein MotB; Reviewed; Region: motB; PRK07734
1415784004997	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
1415784004998	Domain of unknown function (DUF4355); Region: DUF4355; pfam14265
1415784004999	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1415784005000	ligand binding site [chemical binding]; other site
1415784005001	flagellar motor protein MotA; Validated; Region: PRK08124
1415784005002	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
1415784005003	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
1415784005004	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1415784005005	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1415784005006	active site
1415784005007	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640
1415784005008	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1415784005009	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1415784005010	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641
1415784005011	L-aspartate oxidase; Provisional; Region: PRK06175
1415784005012	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1415784005013	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
1415784005014	Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497
1415784005015	putative Iron-sulfur protein interface [polypeptide binding]; other site
1415784005016	proximal heme binding site [chemical binding]; other site
1415784005017	distal heme binding site [chemical binding]; other site
1415784005018	putative dimer interface [polypeptide binding]; other site
1415784005019	Protein of unknown function (DUF2507); Region: DUF2507; pfam10702
1415784005020	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1415784005021	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1415784005022	GIY-YIG motif/motif A; other site
1415784005023	active site
1415784005024	catalytic site [active]
1415784005025	putative DNA binding site [nucleotide binding]; other site
1415784005026	metal binding site [ion binding]; metal-binding site
1415784005027	UvrB/uvrC motif; Region: UVR; pfam02151
1415784005028	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1415784005029	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1415784005030	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1415784005031	catalytic residues [active]
1415784005032	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1415784005033	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1415784005034	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1415784005035	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1415784005036	Ligand binding site [chemical binding]; other site
1415784005037	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1415784005038	enoyl-CoA hydratase; Provisional; Region: PRK07658
1415784005039	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1415784005040	substrate binding site [chemical binding]; other site
1415784005041	oxyanion hole (OAH) forming residues; other site
1415784005042	trimer interface [polypeptide binding]; other site
1415784005043	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
1415784005044	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1415784005045	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1415784005046	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
1415784005047	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710
1415784005048	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1415784005049	acyl-activating enzyme (AAE) consensus motif; other site
1415784005050	putative AMP binding site [chemical binding]; other site
1415784005051	putative active site [active]
1415784005052	putative CoA binding site [chemical binding]; other site
1415784005053	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
1415784005054	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1415784005055	siderophore binding site; other site
1415784005056	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1415784005057	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1415784005058	ABC-ATPase subunit  interface; other site
1415784005059	dimer interface [polypeptide binding]; other site
1415784005060	putative PBP binding regions; other site
1415784005061	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1415784005062	ABC-ATPase subunit  interface; other site
1415784005063	dimer interface [polypeptide binding]; other site
1415784005064	putative PBP binding regions; other site
1415784005065	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1415784005066	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1415784005067	DNA binding residues [nucleotide binding]
1415784005068	DinB family; Region: DinB; pfam05163
1415784005069	DinB superfamily; Region: DinB_2; pfam12867
1415784005070	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
1415784005071	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
1415784005072	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
1415784005073	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1415784005074	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
1415784005075	Walker A/P-loop; other site
1415784005076	ATP binding site [chemical binding]; other site
1415784005077	Q-loop/lid; other site
1415784005078	ABC transporter signature motif; other site
1415784005079	Walker B; other site
1415784005080	D-loop; other site
1415784005081	H-loop/switch region; other site
1415784005082	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1415784005083	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1415784005084	dimer interface [polypeptide binding]; other site
1415784005085	phosphorylation site [posttranslational modification]
1415784005086	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784005087	ATP binding site [chemical binding]; other site
1415784005088	Mg2+ binding site [ion binding]; other site
1415784005089	G-X-G motif; other site
1415784005090	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1415784005091	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784005092	active site
1415784005093	phosphorylation site [posttranslational modification]
1415784005094	intermolecular recognition site; other site
1415784005095	dimerization interface [polypeptide binding]; other site
1415784005096	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1415784005097	DNA binding site [nucleotide binding]
1415784005098	Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962
1415784005099	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
1415784005100	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
1415784005101	putative RNA binding site [nucleotide binding]; other site
1415784005102	heme-degrading monooxygenase IsdG; Provisional; Region: PRK13314
1415784005103	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
1415784005104	active site
1415784005105	catalytic site [active]
1415784005106	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1415784005107	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1415784005108	Walker A/P-loop; other site
1415784005109	ATP binding site [chemical binding]; other site
1415784005110	Q-loop/lid; other site
1415784005111	ABC transporter signature motif; other site
1415784005112	Walker B; other site
1415784005113	D-loop; other site
1415784005114	H-loop/switch region; other site
1415784005115	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1415784005116	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1415784005117	ABC-ATPase subunit  interface; other site
1415784005118	dimer interface [polypeptide binding]; other site
1415784005119	putative PBP binding regions; other site
1415784005120	heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659
1415784005121	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1415784005122	intersubunit interface [polypeptide binding]; other site
1415784005123	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1415784005124	heme-binding site [chemical binding]; other site
1415784005125	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1415784005126	heme-binding site [chemical binding]; other site
1415784005127	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1415784005128	heme-binding site [chemical binding]; other site
1415784005129	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1415784005130	heme-binding site [chemical binding]; other site
1415784005131	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1415784005132	heme-binding site [chemical binding]; other site
1415784005133	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1415784005134	heme-binding site [chemical binding]; other site
1415784005135	heme uptake protein IsdC; Region: IsdC; TIGR03656
1415784005136	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1415784005137	heme-binding site [chemical binding]; other site
1415784005138	sortase B cell surface sorting signal; Region: srtB_target; TIGR03063
1415784005139	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1415784005140	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1415784005141	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1415784005142	RNA binding surface [nucleotide binding]; other site
1415784005143	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
1415784005144	probable active site [active]
1415784005145	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
1415784005146	MutS domain III; Region: MutS_III; pfam05192
1415784005147	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
1415784005148	Walker A/P-loop; other site
1415784005149	ATP binding site [chemical binding]; other site
1415784005150	Q-loop/lid; other site
1415784005151	ABC transporter signature motif; other site
1415784005152	Walker B; other site
1415784005153	D-loop; other site
1415784005154	H-loop/switch region; other site
1415784005155	Smr domain; Region: Smr; pfam01713
1415784005156	hypothetical protein; Provisional; Region: PRK08609
1415784005157	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
1415784005158	active site
1415784005159	primer binding site [nucleotide binding]; other site
1415784005160	NTP  binding site [chemical binding]; other site
1415784005161	metal binding triad [ion binding]; metal-binding site
1415784005162	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
1415784005163	active site
1415784005164	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
1415784005165	Colicin V production protein; Region: Colicin_V; pfam02674
1415784005166	cell division protein ZapA; Provisional; Region: PRK14126
1415784005167	ribonuclease HIII; Provisional; Region: PRK00996
1415784005168	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
1415784005169	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
1415784005170	RNA/DNA hybrid binding site [nucleotide binding]; other site
1415784005171	active site
1415784005172	short chain dehydrogenase; Provisional; Region: PRK06197
1415784005173	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
1415784005174	putative NAD(P) binding site [chemical binding]; other site
1415784005175	active site
1415784005176	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
1415784005177	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
1415784005178	putative dimer interface [polypeptide binding]; other site
1415784005179	putative anticodon binding site; other site
1415784005180	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
1415784005181	homodimer interface [polypeptide binding]; other site
1415784005182	motif 1; other site
1415784005183	motif 2; other site
1415784005184	active site
1415784005185	motif 3; other site
1415784005186	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1415784005187	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1415784005188	putative tRNA-binding site [nucleotide binding]; other site
1415784005189	B3/4 domain; Region: B3_4; pfam03483
1415784005190	tRNA synthetase B5 domain; Region: B5; smart00874
1415784005191	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1415784005192	dimer interface [polypeptide binding]; other site
1415784005193	motif 1; other site
1415784005194	motif 3; other site
1415784005195	motif 2; other site
1415784005196	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1415784005197	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1415784005198	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1415784005199	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1415784005200	dimer interface [polypeptide binding]; other site
1415784005201	motif 1; other site
1415784005202	active site
1415784005203	motif 2; other site
1415784005204	motif 3; other site
1415784005205	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1415784005206	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1415784005207	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1415784005208	small acid-soluble spore protein SspI; Provisional; Region: PRK02955
1415784005209	HD domain; Region: HD; pfam01966
1415784005210	Zn2+ binding site [ion binding]; other site
1415784005211	Mg2+ binding site [ion binding]; other site
1415784005212	CAAX protease self-immunity; Region: Abi; pfam02517
1415784005213	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784005214	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1415784005215	putative substrate translocation pore; other site
1415784005216	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784005217	HlyD family secretion protein; Region: HlyD_3; pfam13437
1415784005218	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
1415784005219	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1415784005220	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
1415784005221	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1415784005222	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
1415784005223	oligomer interface [polypeptide binding]; other site
1415784005224	active site
1415784005225	metal binding site [ion binding]; metal-binding site
1415784005226	dUTPase; Region: dUTPase_2; pfam08761
1415784005227	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527
1415784005228	active site
1415784005229	homodimer interface [polypeptide binding]; other site
1415784005230	metal binding site [ion binding]; metal-binding site
1415784005231	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1415784005232	23S rRNA binding site [nucleotide binding]; other site
1415784005233	L21 binding site [polypeptide binding]; other site
1415784005234	L13 binding site [polypeptide binding]; other site
1415784005235	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1415784005236	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1415784005237	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1415784005238	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1415784005239	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1415784005240	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1415784005241	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1415784005242	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1415784005243	active site
1415784005244	dimer interface [polypeptide binding]; other site
1415784005245	motif 1; other site
1415784005246	motif 2; other site
1415784005247	motif 3; other site
1415784005248	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1415784005249	anticodon binding site; other site
1415784005250	putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834
1415784005251	primosomal protein DnaI; Reviewed; Region: PRK08939
1415784005252	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
1415784005253	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1415784005254	Walker A motif; other site
1415784005255	ATP binding site [chemical binding]; other site
1415784005256	Walker B motif; other site
1415784005257	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
1415784005258	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1415784005259	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1415784005260	ATP cone domain; Region: ATP-cone; pfam03477
1415784005261	S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124
1415784005262	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729
1415784005263	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
1415784005264	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1415784005265	dephospho-CoA kinase; Region: TIGR00152
1415784005266	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1415784005267	CoA-binding site [chemical binding]; other site
1415784005268	ATP-binding [chemical binding]; other site
1415784005269	putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840
1415784005270	Domain of unknown function DUF; Region: DUF204; pfam02659
1415784005271	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1415784005272	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1415784005273	DNA binding site [nucleotide binding]
1415784005274	catalytic residue [active]
1415784005275	H2TH interface [polypeptide binding]; other site
1415784005276	putative catalytic residues [active]
1415784005277	turnover-facilitating residue; other site
1415784005278	intercalation triad [nucleotide binding]; other site
1415784005279	8OG recognition residue [nucleotide binding]; other site
1415784005280	putative reading head residues; other site
1415784005281	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1415784005282	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1415784005283	DNA polymerase I; Provisional; Region: PRK05755
1415784005284	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1415784005285	active site
1415784005286	metal binding site 1 [ion binding]; metal-binding site
1415784005287	putative 5' ssDNA interaction site; other site
1415784005288	metal binding site 3; metal-binding site
1415784005289	metal binding site 2 [ion binding]; metal-binding site
1415784005290	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1415784005291	putative DNA binding site [nucleotide binding]; other site
1415784005292	putative metal binding site [ion binding]; other site
1415784005293	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
1415784005294	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1415784005295	active site
1415784005296	DNA binding site [nucleotide binding]
1415784005297	catalytic site [active]
1415784005298	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1415784005299	dimerization interface [polypeptide binding]; other site
1415784005300	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1415784005301	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1415784005302	putative active site [active]
1415784005303	heme pocket [chemical binding]; other site
1415784005304	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1415784005305	dimer interface [polypeptide binding]; other site
1415784005306	phosphorylation site [posttranslational modification]
1415784005307	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784005308	ATP binding site [chemical binding]; other site
1415784005309	Mg2+ binding site [ion binding]; other site
1415784005310	G-X-G motif; other site
1415784005311	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1415784005312	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784005313	active site
1415784005314	phosphorylation site [posttranslational modification]
1415784005315	intermolecular recognition site; other site
1415784005316	dimerization interface [polypeptide binding]; other site
1415784005317	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1415784005318	DNA binding site [nucleotide binding]
1415784005319	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1415784005320	active site 2 [active]
1415784005321	active site 1 [active]
1415784005322	malate dehydrogenase; Reviewed; Region: PRK06223
1415784005323	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
1415784005324	NAD(P) binding site [chemical binding]; other site
1415784005325	dimer interface [polypeptide binding]; other site
1415784005326	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1415784005327	substrate binding site [chemical binding]; other site
1415784005328	isocitrate dehydrogenase; Reviewed; Region: PRK07006
1415784005329	isocitrate dehydrogenase; Validated; Region: PRK07362
1415784005330	Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110
1415784005331	dimer interface [polypeptide binding]; other site
1415784005332	Citrate synthase; Region: Citrate_synt; pfam00285
1415784005333	active site
1415784005334	citrylCoA binding site [chemical binding]; other site
1415784005335	oxalacetate/citrate binding site [chemical binding]; other site
1415784005336	coenzyme A binding site [chemical binding]; other site
1415784005337	catalytic triad [active]
1415784005338	Protein of unknown function (DUF441); Region: DUF441; pfam04284
1415784005339	sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872
1415784005340	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1415784005341	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
1415784005342	pyruvate kinase; Provisional; Region: PRK06354
1415784005343	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1415784005344	domain interfaces; other site
1415784005345	active site
1415784005346	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700
1415784005347	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
1415784005348	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
1415784005349	active site
1415784005350	ADP/pyrophosphate binding site [chemical binding]; other site
1415784005351	dimerization interface [polypeptide binding]; other site
1415784005352	allosteric effector site; other site
1415784005353	fructose-1,6-bisphosphate binding site; other site
1415784005354	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
1415784005355	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
1415784005356	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
1415784005357	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
1415784005358	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1415784005359	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1415784005360	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1415784005361	DNA-binding site [nucleotide binding]; DNA binding site
1415784005362	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
1415784005363	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1415784005364	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1415784005365	putative NAD(P) binding site [chemical binding]; other site
1415784005366	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920
1415784005367	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1415784005368	active site
1415784005369	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1415784005370	generic binding surface II; other site
1415784005371	generic binding surface I; other site
1415784005372	Sporulation protein YtrH; Region: Spore_YtrH; pfam14034
1415784005373	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1415784005374	DHH family; Region: DHH; pfam01368
1415784005375	DHHA1 domain; Region: DHHA1; pfam02272
1415784005376	YtpI-like protein; Region: YtpI; pfam14007
1415784005377	Protein of unknown function (DUF3949); Region: DUF3949; pfam13133
1415784005378	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
1415784005379	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1415784005380	DNA-binding site [nucleotide binding]; DNA binding site
1415784005381	DRTGG domain; Region: DRTGG; pfam07085
1415784005382	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
1415784005383	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
1415784005384	active site 2 [active]
1415784005385	active site 1 [active]
1415784005386	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1415784005387	metal-dependent hydrolase; Provisional; Region: PRK00685
1415784005388	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1415784005389	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1415784005390	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1415784005391	active site
1415784005392	Protein of unknown function (DUF3221); Region: DUF3221; pfam11518
1415784005393	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
1415784005394	GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746
1415784005395	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1415784005396	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
1415784005397	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1415784005398	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1415784005399	hexamer interface [polypeptide binding]; other site
1415784005400	ligand binding site [chemical binding]; other site
1415784005401	putative active site [active]
1415784005402	NAD(P) binding site [chemical binding]; other site
1415784005403	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
1415784005404	classical (c) SDRs; Region: SDR_c; cd05233
1415784005405	NAD(P) binding site [chemical binding]; other site
1415784005406	active site
1415784005407	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1415784005408	Ligand Binding Site [chemical binding]; other site
1415784005409	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1415784005410	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
1415784005411	Protein of unknown function (DUF3139); Region: DUF3139; pfam11337
1415784005412	argininosuccinate lyase; Provisional; Region: PRK00855
1415784005413	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1415784005414	active sites [active]
1415784005415	tetramer interface [polypeptide binding]; other site
1415784005416	argininosuccinate synthase; Provisional; Region: PRK13820
1415784005417	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1415784005418	ANP binding site [chemical binding]; other site
1415784005419	Substrate Binding Site II [chemical binding]; other site
1415784005420	Substrate Binding Site I [chemical binding]; other site
1415784005421	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1415784005422	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1415784005423	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1415784005424	EcsC protein family; Region: EcsC; pfam12787
1415784005425	Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795
1415784005426	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1415784005427	nudix motif; other site
1415784005428	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1415784005429	propionate/acetate kinase; Provisional; Region: PRK12379
1415784005430	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
1415784005431	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784005432	S-adenosylmethionine binding site [chemical binding]; other site
1415784005433	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1415784005434	dimer interface [polypeptide binding]; other site
1415784005435	catalytic triad [active]
1415784005436	peroxidatic and resolving cysteines [active]
1415784005437	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
1415784005438	Protein of unknown function (DUF2953); Region: DUF2953; pfam11167
1415784005439	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501
1415784005440	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1415784005441	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1415784005442	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1415784005443	active site
1415784005444	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1415784005445	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1415784005446	dimer interface [polypeptide binding]; other site
1415784005447	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
1415784005448	Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972
1415784005449	active site
1415784005450	acyl-activating enzyme (AAE) consensus motif; other site
1415784005451	putative CoA binding site [chemical binding]; other site
1415784005452	AMP binding site [chemical binding]; other site
1415784005453	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
1415784005454	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
1415784005455	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
1415784005456	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
1415784005457	Ligand Binding Site [chemical binding]; other site
1415784005458	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1415784005459	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1415784005460	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1415784005461	catalytic residue [active]
1415784005462	septation ring formation regulator EzrA; Provisional; Region: PRK04778
1415784005463	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1415784005464	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1415784005465	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1415784005466	dimerization interface [polypeptide binding]; other site
1415784005467	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1415784005468	EamA-like transporter family; Region: EamA; pfam00892
1415784005469	EamA-like transporter family; Region: EamA; pfam00892
1415784005470	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1415784005471	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1415784005472	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
1415784005473	GAF domain; Region: GAF_2; pfam13185
1415784005474	methionine gamma-lyase; Provisional; Region: PRK06767
1415784005475	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1415784005476	homodimer interface [polypeptide binding]; other site
1415784005477	substrate-cofactor binding pocket; other site
1415784005478	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784005479	catalytic residue [active]
1415784005480	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1415784005481	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1415784005482	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1415784005483	RNA binding surface [nucleotide binding]; other site
1415784005484	Uncharacterized conserved protein [Function unknown]; Region: COG4748
1415784005485	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
1415784005486	Domain of unknown function (DUF4306); Region: DUF4306; pfam14154
1415784005487	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1415784005488	catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395
1415784005489	active site
1415784005490	HIGH motif; other site
1415784005491	dimer interface [polypeptide binding]; other site
1415784005492	KMSKS motif; other site
1415784005493	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1415784005494	RNA binding surface [nucleotide binding]; other site
1415784005495	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1415784005496	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1415784005497	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1415784005498	DNA binding residues [nucleotide binding]
1415784005499	maltose O-acetyltransferase; Provisional; Region: PRK10092
1415784005500	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1415784005501	active site
1415784005502	substrate binding site [chemical binding]; other site
1415784005503	trimer interface [polypeptide binding]; other site
1415784005504	CoA binding site [chemical binding]; other site
1415784005505	acetyl-CoA synthetase; Provisional; Region: PRK04319
1415784005506	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
1415784005507	Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969
1415784005508	active site
1415784005509	acyl-activating enzyme (AAE) consensus motif; other site
1415784005510	putative CoA binding site [chemical binding]; other site
1415784005511	AMP binding site [chemical binding]; other site
1415784005512	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1415784005513	Coenzyme A binding pocket [chemical binding]; other site
1415784005514	FOG: CBS domain [General function prediction only]; Region: COG0517
1415784005515	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc; cd04584
1415784005516	C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883
1415784005517	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
1415784005518	Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
1415784005519	active site
1415784005520	Zn binding site [ion binding]; other site
1415784005521	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
1415784005522	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1415784005523	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784005524	active site
1415784005525	phosphorylation site [posttranslational modification]
1415784005526	intermolecular recognition site; other site
1415784005527	dimerization interface [polypeptide binding]; other site
1415784005528	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1415784005529	DNA binding site [nucleotide binding]
1415784005530	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1415784005531	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1415784005532	dimerization interface [polypeptide binding]; other site
1415784005533	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1415784005534	dimer interface [polypeptide binding]; other site
1415784005535	phosphorylation site [posttranslational modification]
1415784005536	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784005537	ATP binding site [chemical binding]; other site
1415784005538	Mg2+ binding site [ion binding]; other site
1415784005539	G-X-G motif; other site
1415784005540	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1415784005541	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529
1415784005542	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1415784005543	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
1415784005544	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1415784005545	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1415784005546	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955
1415784005547	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1415784005548	Protein of unknown function (DUF3917); Region: DUF3917; pfam13055
1415784005549	Protein of unknown function (DUF3949); Region: DUF3949; pfam13133
1415784005550	Domain of unknown function (DUF4288); Region: DUF4288; pfam14119
1415784005551	catabolite control protein A; Region: ccpA; TIGR01481
1415784005552	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1415784005553	DNA binding site [nucleotide binding]
1415784005554	domain linker motif; other site
1415784005555	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
1415784005556	dimerization interface [polypeptide binding]; other site
1415784005557	effector binding site; other site
1415784005558	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
1415784005559	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
1415784005560	putative dimer interface [polypeptide binding]; other site
1415784005561	CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537
1415784005562	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
1415784005563	putative dimer interface [polypeptide binding]; other site
1415784005564	Protein of unknown function (DUF2847); Region: DUF2847; pfam11009
1415784005565	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
1415784005566	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
1415784005567	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
1415784005568	Domain of unknown function (DUF1200); Region: DUF1200; pfam06713
1415784005569	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1415784005570	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784005571	Coenzyme A binding pocket [chemical binding]; other site
1415784005572	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1415784005573	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1415784005574	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1415784005575	EamA-like transporter family; Region: EamA; pfam00892
1415784005576	EamA-like transporter family; Region: EamA; pfam00892
1415784005577	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1415784005578	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1415784005579	DNA binding residues [nucleotide binding]
1415784005580	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1415784005581	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1415784005582	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1415784005583	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1415784005584	nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188
1415784005585	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571
1415784005586	active site
1415784005587	MARCKS family; Region: MARCKS; pfam02063
1415784005588	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1415784005589	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1415784005590	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1415784005591	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1415784005592	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1415784005593	active site
1415784005594	metal binding site [ion binding]; metal-binding site
1415784005595	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1415784005596	putative tRNA-binding site [nucleotide binding]; other site
1415784005597	hypothetical protein; Provisional; Region: PRK13668
1415784005598	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1415784005599	catalytic residues [active]
1415784005600	NTPase; Reviewed; Region: PRK03114
1415784005601	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1415784005602	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
1415784005603	oligomer interface [polypeptide binding]; other site
1415784005604	active site
1415784005605	metal binding site [ion binding]; metal-binding site
1415784005606	Predicted small secreted protein [Function unknown]; Region: COG5584
1415784005607	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1415784005608	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784005609	S-adenosylmethionine binding site [chemical binding]; other site
1415784005610	YtzH-like protein; Region: YtzH; pfam14165
1415784005611	Phosphotransferase enzyme family; Region: APH; pfam01636
1415784005612	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1415784005613	active site
1415784005614	substrate binding site [chemical binding]; other site
1415784005615	ATP binding site [chemical binding]; other site
1415784005616	pullulanase, type I; Region: pulA_typeI; TIGR02104
1415784005617	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
1415784005618	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
1415784005619	Ca binding site [ion binding]; other site
1415784005620	active site
1415784005621	catalytic site [active]
1415784005622	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
1415784005623	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1415784005624	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1415784005625	dipeptidase PepV; Reviewed; Region: PRK07318
1415784005626	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
1415784005627	active site
1415784005628	metal binding site [ion binding]; metal-binding site
1415784005629	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1415784005630	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1415784005631	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1415784005632	RNA binding surface [nucleotide binding]; other site
1415784005633	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
1415784005634	active site
1415784005635	uracil binding [chemical binding]; other site
1415784005636	stage V sporulation protein B; Region: spore_V_B; TIGR02900
1415784005637	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1415784005638	HI0933-like protein; Region: HI0933_like; pfam03486
1415784005639	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1415784005640	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784005641	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1415784005642	putative substrate translocation pore; other site
1415784005643	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784005644	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1415784005645	dimerization interface [polypeptide binding]; other site
1415784005646	putative DNA binding site [nucleotide binding]; other site
1415784005647	putative Zn2+ binding site [ion binding]; other site
1415784005648	Slx4 endonuclease; Region: Slx4; pfam09494
1415784005649	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1415784005650	putative hydrophobic ligand binding site [chemical binding]; other site
1415784005651	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1415784005652	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1415784005653	Probable transposase; Region: OrfB_IS605; pfam01385
1415784005654	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
1415784005655	Domain of unknown function (DUF3973); Region: DUF3973; pfam13119
1415784005656	Protein of unknown function (DUF2758); Region: DUF2758; pfam10957
1415784005657	Protein of unknown function (DUF2553); Region: DUF2553; pfam10830
1415784005658	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
1415784005659	glucose-1-dehydrogenase; Provisional; Region: PRK08936
1415784005660	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
1415784005661	NAD binding site [chemical binding]; other site
1415784005662	homodimer interface [polypeptide binding]; other site
1415784005663	active site
1415784005664	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
1415784005665	L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728
1415784005666	Protein of unknown function (DUF3888); Region: DUF3888; pfam13027
1415784005667	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1415784005668	MoaE interaction surface [polypeptide binding]; other site
1415784005669	MoeB interaction surface [polypeptide binding]; other site
1415784005670	thiocarboxylated glycine; other site
1415784005671	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1415784005672	MoaE homodimer interface [polypeptide binding]; other site
1415784005673	MoaD interaction [polypeptide binding]; other site
1415784005674	active site residues [active]
1415784005675	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
1415784005676	Walker A motif; other site
1415784005677	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1415784005678	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1415784005679	dimer interface [polypeptide binding]; other site
1415784005680	putative functional site; other site
1415784005681	putative MPT binding site; other site
1415784005682	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1415784005683	trimer interface [polypeptide binding]; other site
1415784005684	dimer interface [polypeptide binding]; other site
1415784005685	putative active site [active]
1415784005686	thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475
1415784005687	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1415784005688	ATP binding site [chemical binding]; other site
1415784005689	substrate interface [chemical binding]; other site
1415784005690	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
1415784005691	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1415784005692	FeS/SAM binding site; other site
1415784005693	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1415784005694	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
1415784005695	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1415784005696	active site residue [active]
1415784005697	homoserine O-acetyltransferase; Provisional; Region: PRK06765
1415784005698	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1415784005699	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1415784005700	Spore germination protein; Region: Spore_permease; pfam03845
1415784005701	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1415784005702	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1415784005703	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545
1415784005704	putative nucleotide binding site [chemical binding]; other site
1415784005705	putative metal binding site [ion binding]; other site
1415784005706	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784005707	Coenzyme A binding pocket [chemical binding]; other site
1415784005708	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1415784005709	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1415784005710	HIGH motif; other site
1415784005711	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1415784005712	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1415784005713	active site
1415784005714	KMSKS motif; other site
1415784005715	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1415784005716	tRNA binding surface [nucleotide binding]; other site
1415784005717	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784005718	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1415784005719	putative substrate translocation pore; other site
1415784005720	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1415784005721	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1415784005722	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
1415784005723	TrkA-C domain; Region: TrkA_C; pfam02080
1415784005724	INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186
1415784005725	Int/Topo IB signature motif; other site
1415784005726	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1415784005727	FtsX-like permease family; Region: FtsX; pfam02687
1415784005728	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1415784005729	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1415784005730	Walker A/P-loop; other site
1415784005731	ATP binding site [chemical binding]; other site
1415784005732	Q-loop/lid; other site
1415784005733	ABC transporter signature motif; other site
1415784005734	Walker B; other site
1415784005735	D-loop; other site
1415784005736	H-loop/switch region; other site
1415784005737	Protein of unknown function (DUF418); Region: DUF418; cl12135
1415784005738	Protein of unknown function (DUF418); Region: DUF418; pfam04235
1415784005739	Protein of unknown function (DUF2524); Region: DUF2524; pfam10732
1415784005740	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
1415784005741	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1415784005742	FeS/SAM binding site; other site
1415784005743	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784005744	S-adenosylmethionine binding site [chemical binding]; other site
1415784005745	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
1415784005746	aspartate racemase; Region: asp_race; TIGR00035
1415784005747	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1415784005748	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
1415784005749	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1415784005750	Protein of unknown function (DUF2600); Region: DUF2600; pfam10776
1415784005751	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1415784005752	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1415784005753	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1415784005754	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1415784005755	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1415784005756	trimer interface [polypeptide binding]; other site
1415784005757	putative metal binding site [ion binding]; other site
1415784005758	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1415784005759	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
1415784005760	active site
1415784005761	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1415784005762	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
1415784005763	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
1415784005764	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1415784005765	GTP binding site; other site
1415784005766	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1415784005767	MPT binding site; other site
1415784005768	trimer interface [polypeptide binding]; other site
1415784005769	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1415784005770	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1415784005771	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1415784005772	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1415784005773	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
1415784005774	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
1415784005775	active site
1415784005776	substrate-binding site [chemical binding]; other site
1415784005777	metal-binding site [ion binding]
1415784005778	ATP binding site [chemical binding]; other site
1415784005779	ATP synthase I chain; Region: ATP_synt_I; pfam03899
1415784005780	EamA-like transporter family; Region: EamA; pfam00892
1415784005781	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1415784005782	EamA-like transporter family; Region: EamA; pfam00892
1415784005783	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918
1415784005784	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1415784005785	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1415784005786	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784005787	ATP binding site [chemical binding]; other site
1415784005788	Mg2+ binding site [ion binding]; other site
1415784005789	G-X-G motif; other site
1415784005790	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1415784005791	dimer interface [polypeptide binding]; other site
1415784005792	phosphorylation site [posttranslational modification]
1415784005793	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784005794	ATP binding site [chemical binding]; other site
1415784005795	Mg2+ binding site [ion binding]; other site
1415784005796	G-X-G motif; other site
1415784005797	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
1415784005798	heme binding pocket [chemical binding]; other site
1415784005799	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1415784005800	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1415784005801	Sulfatase; Region: Sulfatase; pfam00884
1415784005802	Protein of unknown function (DUF3986); Region: DUF3986; pfam13143
1415784005803	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1415784005804	NMT1-like family; Region: NMT1_2; pfam13379
1415784005805	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1415784005806	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1415784005807	Walker A/P-loop; other site
1415784005808	ATP binding site [chemical binding]; other site
1415784005809	Q-loop/lid; other site
1415784005810	ABC transporter signature motif; other site
1415784005811	Walker B; other site
1415784005812	D-loop; other site
1415784005813	H-loop/switch region; other site
1415784005814	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1415784005815	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784005816	dimer interface [polypeptide binding]; other site
1415784005817	conserved gate region; other site
1415784005818	putative PBP binding loops; other site
1415784005819	ABC-ATPase subunit interface; other site
1415784005820	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
1415784005821	active site
1415784005822	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1415784005823	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1415784005824	motif II; other site
1415784005825	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
1415784005826	nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705
1415784005827	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665
1415784005828	nudix motif; other site
1415784005829	Protein of unknown function (DUF3953); Region: DUF3953; pfam13129
1415784005830	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1415784005831	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1415784005832	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
1415784005833	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1415784005834	DNA binding residues [nucleotide binding]
1415784005835	dimer interface [polypeptide binding]; other site
1415784005836	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
1415784005837	S-ribosylhomocysteinase; Provisional; Region: PRK02260
1415784005838	Haemolytic domain; Region: Haemolytic; pfam01809
1415784005839	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
1415784005840	active site clefts [active]
1415784005841	zinc binding site [ion binding]; other site
1415784005842	dimer interface [polypeptide binding]; other site
1415784005843	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1415784005844	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1415784005845	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1415784005846	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
1415784005847	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1415784005848	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1415784005849	putative active site [active]
1415784005850	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1415784005851	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1415784005852	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1415784005853	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1415784005854	Domain of unknown function (DUF4247); Region: DUF4247; pfam14042
1415784005855	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
1415784005856	Predicted membrane protein [Function unknown]; Region: COG3766
1415784005857	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
1415784005858	hypothetical protein; Provisional; Region: PRK12473
1415784005859	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
1415784005860	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
1415784005861	G1 box; other site
1415784005862	GTP/Mg2+ binding site [chemical binding]; other site
1415784005863	Switch I region; other site
1415784005864	G2 box; other site
1415784005865	G3 box; other site
1415784005866	Switch II region; other site
1415784005867	G4 box; other site
1415784005868	G5 box; other site
1415784005869	Nucleoside recognition; Region: Gate; pfam07670
1415784005870	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
1415784005871	Nucleoside recognition; Region: Gate; pfam07670
1415784005872	FeoA domain; Region: FeoA; pfam04023
1415784005873	Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515
1415784005874	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1415784005875	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1415784005876	dimerization interface [polypeptide binding]; other site
1415784005877	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1415784005878	dimer interface [polypeptide binding]; other site
1415784005879	phosphorylation site [posttranslational modification]
1415784005880	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784005881	ATP binding site [chemical binding]; other site
1415784005882	Mg2+ binding site [ion binding]; other site
1415784005883	G-X-G motif; other site
1415784005884	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1415784005885	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784005886	active site
1415784005887	phosphorylation site [posttranslational modification]
1415784005888	intermolecular recognition site; other site
1415784005889	dimerization interface [polypeptide binding]; other site
1415784005890	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1415784005891	DNA binding site [nucleotide binding]
1415784005892	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828
1415784005893	active site
1415784005894	catalytic site [active]
1415784005895	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1415784005896	active site
1415784005897	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1415784005898	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1415784005899	Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048
1415784005900	Domain of unknown function (DUF4262); Region: DUF4262; pfam14081
1415784005901	Domain of unknown function (DUF4261); Region: DUF4261; pfam14080
1415784005902	FtsX-like permease family; Region: FtsX; pfam02687
1415784005903	FtsX-like permease family; Region: FtsX; pfam02687
1415784005904	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1415784005905	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1415784005906	Walker A/P-loop; other site
1415784005907	ATP binding site [chemical binding]; other site
1415784005908	Q-loop/lid; other site
1415784005909	ABC transporter signature motif; other site
1415784005910	Walker B; other site
1415784005911	D-loop; other site
1415784005912	H-loop/switch region; other site
1415784005913	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
1415784005914	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1415784005915	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1415784005916	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784005917	S-adenosylmethionine binding site [chemical binding]; other site
1415784005918	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1415784005919	FtsX-like permease family; Region: FtsX; pfam02687
1415784005920	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1415784005921	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1415784005922	Walker A/P-loop; other site
1415784005923	ATP binding site [chemical binding]; other site
1415784005924	Q-loop/lid; other site
1415784005925	ABC transporter signature motif; other site
1415784005926	Walker B; other site
1415784005927	D-loop; other site
1415784005928	H-loop/switch region; other site
1415784005929	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1415784005930	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1415784005931	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
1415784005932	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1415784005933	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1415784005934	Walker A/P-loop; other site
1415784005935	ATP binding site [chemical binding]; other site
1415784005936	Q-loop/lid; other site
1415784005937	ABC transporter signature motif; other site
1415784005938	Walker B; other site
1415784005939	D-loop; other site
1415784005940	H-loop/switch region; other site
1415784005941	Predicted integral membrane protein [Function unknown]; Region: COG5658
1415784005942	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
1415784005943	SdpI/YhfL protein family; Region: SdpI; pfam13630
1415784005944	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1415784005945	dimerization interface [polypeptide binding]; other site
1415784005946	putative DNA binding site [nucleotide binding]; other site
1415784005947	putative Zn2+ binding site [ion binding]; other site
1415784005948	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
1415784005949	RNA polymerase sigma factor; Provisional; Region: PRK12543
1415784005950	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1415784005951	DNA binding residues [nucleotide binding]
1415784005952	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1415784005953	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784005954	active site
1415784005955	phosphorylation site [posttranslational modification]
1415784005956	intermolecular recognition site; other site
1415784005957	dimerization interface [polypeptide binding]; other site
1415784005958	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1415784005959	DNA binding site [nucleotide binding]
1415784005960	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1415784005961	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
1415784005962	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784005963	ATP binding site [chemical binding]; other site
1415784005964	Mg2+ binding site [ion binding]; other site
1415784005965	G-X-G motif; other site
1415784005966	FtsX-like permease family; Region: FtsX; pfam02687
1415784005967	FtsX-like permease family; Region: FtsX; pfam02687
1415784005968	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1415784005969	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1415784005970	Walker A/P-loop; other site
1415784005971	ATP binding site [chemical binding]; other site
1415784005972	Q-loop/lid; other site
1415784005973	ABC transporter signature motif; other site
1415784005974	Walker B; other site
1415784005975	D-loop; other site
1415784005976	H-loop/switch region; other site
1415784005977	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1415784005978	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1415784005979	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1415784005980	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1415784005981	DNA-binding site [nucleotide binding]; DNA binding site
1415784005982	UTRA domain; Region: UTRA; pfam07702
1415784005983	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1415784005984	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1415784005985	substrate binding site [chemical binding]; other site
1415784005986	ATP binding site [chemical binding]; other site
1415784005987	conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581
1415784005988	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1415784005989	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1415784005990	catalytic residue [active]
1415784005991	probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583
1415784005992	Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307
1415784005993	active site
1415784005994	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
1415784005995	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1415784005996	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
1415784005997	dimerization interface [polypeptide binding]; other site
1415784005998	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1415784005999	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1415784006000	dimer interface [polypeptide binding]; other site
1415784006001	phosphorylation site [posttranslational modification]
1415784006002	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784006003	ATP binding site [chemical binding]; other site
1415784006004	Mg2+ binding site [ion binding]; other site
1415784006005	G-X-G motif; other site
1415784006006	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1415784006007	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784006008	active site
1415784006009	phosphorylation site [posttranslational modification]
1415784006010	intermolecular recognition site; other site
1415784006011	dimerization interface [polypeptide binding]; other site
1415784006012	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1415784006013	DNA binding site [nucleotide binding]
1415784006014	N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317
1415784006015	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
1415784006016	active site
1415784006017	octamer interface [polypeptide binding]; other site
1415784006018	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640
1415784006019	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
1415784006020	acyl-activating enzyme (AAE) consensus motif; other site
1415784006021	putative AMP binding site [chemical binding]; other site
1415784006022	putative active site [active]
1415784006023	putative CoA binding site [chemical binding]; other site
1415784006024	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1415784006025	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
1415784006026	substrate binding site [chemical binding]; other site
1415784006027	oxyanion hole (OAH) forming residues; other site
1415784006028	trimer interface [polypeptide binding]; other site
1415784006029	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
1415784006030	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1415784006031	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
1415784006032	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
1415784006033	dimer interface [polypeptide binding]; other site
1415784006034	tetramer interface [polypeptide binding]; other site
1415784006035	PYR/PP interface [polypeptide binding]; other site
1415784006036	TPP binding site [chemical binding]; other site
1415784006037	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
1415784006038	TPP-binding site; other site
1415784006039	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
1415784006040	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1415784006041	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
1415784006042	UbiA prenyltransferase family; Region: UbiA; pfam01040
1415784006043	regulatory protein, yteA family; Region: bacill_yteA; TIGR02890
1415784006044	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1415784006045	DNA-binding site [nucleotide binding]; DNA binding site
1415784006046	RNA-binding motif; other site
1415784006047	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
1415784006048	Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519
1415784006049	active site flap/lid [active]
1415784006050	nucleophilic elbow; other site
1415784006051	catalytic triad [active]
1415784006052	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1415784006053	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1415784006054	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
1415784006055	homodimer interface [polypeptide binding]; other site
1415784006056	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
1415784006057	active site pocket [active]
1415784006058	glycogen synthase; Provisional; Region: glgA; PRK00654
1415784006059	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
1415784006060	ADP-binding pocket [chemical binding]; other site
1415784006061	homodimer interface [polypeptide binding]; other site
1415784006062	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
1415784006063	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1415784006064	ligand binding site; other site
1415784006065	oligomer interface; other site
1415784006066	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1415784006067	dimer interface [polypeptide binding]; other site
1415784006068	N-terminal domain interface [polypeptide binding]; other site
1415784006069	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
1415784006070	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1415784006071	ligand binding site; other site
1415784006072	oligomer interface; other site
1415784006073	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1415784006074	dimer interface [polypeptide binding]; other site
1415784006075	N-terminal domain interface [polypeptide binding]; other site
1415784006076	sulfate 1 binding site; other site
1415784006077	glycogen branching enzyme; Provisional; Region: PRK12313
1415784006078	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
1415784006079	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
1415784006080	active site
1415784006081	catalytic site [active]
1415784006082	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
1415784006083	Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780
1415784006084	Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547
1415784006085	dockerin binding interface; other site
1415784006086	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
1415784006087	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1415784006088	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1415784006089	NAD binding site [chemical binding]; other site
1415784006090	dimer interface [polypeptide binding]; other site
1415784006091	substrate binding site [chemical binding]; other site
1415784006092	Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800
1415784006093	Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791
1415784006094	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1415784006095	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1415784006096	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1415784006097	DNA binding residues [nucleotide binding]
1415784006098	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
1415784006099	MgtC family; Region: MgtC; pfam02308
1415784006100	Ion channel; Region: Ion_trans_2; pfam07885
1415784006101	TrkA-N domain; Region: TrkA_N; pfam02254
1415784006102	YugN-like family; Region: YugN; pfam08868
1415784006103	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
1415784006104	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1415784006105	active site
1415784006106	dimer interface [polypeptide binding]; other site
1415784006107	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1415784006108	dimer interface [polypeptide binding]; other site
1415784006109	active site
1415784006110	Domain of unknown function (DUF378); Region: DUF378; pfam04070
1415784006111	general stress protein 13; Validated; Region: PRK08059
1415784006112	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1415784006113	RNA binding site [nucleotide binding]; other site
1415784006114	hypothetical protein; Validated; Region: PRK07682
1415784006115	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1415784006116	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784006117	homodimer interface [polypeptide binding]; other site
1415784006118	catalytic residue [active]
1415784006119	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1415784006120	AsnC family; Region: AsnC_trans_reg; pfam01037
1415784006121	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
1415784006122	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
1415784006123	dimerization interface [polypeptide binding]; other site
1415784006124	ligand binding site [chemical binding]; other site
1415784006125	NADP binding site [chemical binding]; other site
1415784006126	catalytic site [active]
1415784006127	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
1415784006128	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1415784006129	nucleophilic elbow; other site
1415784006130	catalytic triad; other site
1415784006131	Domain of unknown function (DUF1871); Region: DUF1871; pfam08958
1415784006132	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
1415784006133	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1415784006134	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784006135	homodimer interface [polypeptide binding]; other site
1415784006136	catalytic residue [active]
1415784006137	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
1415784006138	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
1415784006139	E-class dimer interface [polypeptide binding]; other site
1415784006140	P-class dimer interface [polypeptide binding]; other site
1415784006141	active site
1415784006142	Cu2+ binding site [ion binding]; other site
1415784006143	Zn2+ binding site [ion binding]; other site
1415784006144	Kinase associated protein B; Region: KapB; pfam08810
1415784006145	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
1415784006146	active site
1415784006147	catalytic site [active]
1415784006148	substrate binding site [chemical binding]; other site
1415784006149	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
1415784006150	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
1415784006151	transmembrane helices; other site
1415784006152	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
1415784006153	A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064
1415784006154	active site
1415784006155	glycyl-tRNA synthetase; Provisional; Region: PRK04173
1415784006156	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1415784006157	motif 1; other site
1415784006158	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
1415784006159	active site
1415784006160	motif 2; other site
1415784006161	motif 3; other site
1415784006162	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
1415784006163	anticodon binding site; other site
1415784006164	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1415784006165	CoenzymeA binding site [chemical binding]; other site
1415784006166	subunit interaction site [polypeptide binding]; other site
1415784006167	PHB binding site; other site
1415784006168	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
1415784006169	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
1415784006170	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
1415784006171	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1415784006172	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1415784006173	active site
1415784006174	tetramer interface; other site
1415784006175	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
1415784006176	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
1415784006177	active site
1415784006178	substrate binding site [chemical binding]; other site
1415784006179	metal binding site [ion binding]; metal-binding site
1415784006180	Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372
1415784006181	Uncharacterized conserved protein [Function unknown]; Region: COG1624
1415784006182	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1415784006183	multifunctional aminopeptidase A; Provisional; Region: PRK00913
1415784006184	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1415784006185	interface (dimer of trimers) [polypeptide binding]; other site
1415784006186	Substrate-binding/catalytic site; other site
1415784006187	Zn-binding sites [ion binding]; other site
1415784006188	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
1415784006189	Putative membrane protein; Region: YuiB; pfam14068
1415784006190	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1415784006191	nudix motif; other site
1415784006192	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1415784006193	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1415784006194	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1415784006195	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1415784006196	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1415784006197	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
1415784006198	H+ Antiporter protein; Region: 2A0121; TIGR00900
1415784006199	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784006200	putative substrate translocation pore; other site
1415784006201	Helix-turn-helix domain; Region: HTH_36; pfam13730
1415784006202	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1415784006203	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1415784006204	putative DNA binding site [nucleotide binding]; other site
1415784006205	dimerization interface [polypeptide binding]; other site
1415784006206	Protein of unknown function (DUF523); Region: DUF523; pfam04463
1415784006207	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
1415784006208	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1415784006209	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1415784006210	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
1415784006211	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
1415784006212	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1415784006213	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1415784006214	hypothetical protein; Provisional; Region: PRK13669
1415784006215	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1415784006216	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1415784006217	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1415784006218	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1415784006219	Walker A/P-loop; other site
1415784006220	ATP binding site [chemical binding]; other site
1415784006221	Q-loop/lid; other site
1415784006222	ABC transporter signature motif; other site
1415784006223	Walker B; other site
1415784006224	D-loop; other site
1415784006225	H-loop/switch region; other site
1415784006226	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
1415784006227	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
1415784006228	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
1415784006229	PhnA protein; Region: PhnA; pfam03831
1415784006230	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
1415784006231	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1415784006232	active site
1415784006233	NTP binding site [chemical binding]; other site
1415784006234	metal binding triad [ion binding]; metal-binding site
1415784006235	antibiotic binding site [chemical binding]; other site
1415784006236	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
1415784006237	Protein of unknown function (DUF1462); Region: DUF1462; pfam07315
1415784006238	NifU-like domain; Region: NifU; pfam01106
1415784006239	spore coat protein YutH; Region: spore_yutH; TIGR02905
1415784006240	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
1415784006241	tetramer interfaces [polypeptide binding]; other site
1415784006242	binuclear metal-binding site [ion binding]; other site
1415784006243	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1415784006244	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1415784006245	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1415784006246	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
1415784006247	FtsX-like permease family; Region: FtsX; pfam02687
1415784006248	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1415784006249	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1415784006250	FtsX-like permease family; Region: FtsX; pfam02687
1415784006251	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1415784006252	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1415784006253	Walker A/P-loop; other site
1415784006254	ATP binding site [chemical binding]; other site
1415784006255	Q-loop/lid; other site
1415784006256	ABC transporter signature motif; other site
1415784006257	Walker B; other site
1415784006258	D-loop; other site
1415784006259	H-loop/switch region; other site
1415784006260	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
1415784006261	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1415784006262	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
1415784006263	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1415784006264	active site
1415784006265	motif I; other site
1415784006266	motif II; other site
1415784006267	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1415784006268	Predicted transcriptional regulator [Transcription]; Region: COG2345
1415784006269	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1415784006270	putative Zn2+ binding site [ion binding]; other site
1415784006271	putative DNA binding site [nucleotide binding]; other site
1415784006272	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
1415784006273	Uncharacterized conserved protein [Function unknown]; Region: COG2445
1415784006274	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
1415784006275	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
1415784006276	putative active site [active]
1415784006277	Protein of unknown function (DUF3055); Region: DUF3055; pfam11256
1415784006278	Protein of unknown function (DUF1062); Region: DUF1062; cl01786
1415784006279	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1415784006280	RNA binding surface [nucleotide binding]; other site
1415784006281	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784006282	Coenzyme A binding pocket [chemical binding]; other site
1415784006283	Protein of unknown function (DUF1027); Region: DUF1027; pfam06265
1415784006284	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
1415784006285	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1415784006286	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
1415784006287	DNA binding residues [nucleotide binding]
1415784006288	dimer interface [polypeptide binding]; other site
1415784006289	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
1415784006290	Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086
1415784006291	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1415784006292	catalytic core [active]
1415784006293	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
1415784006294	putative deacylase active site [active]
1415784006295	lipoyl synthase; Provisional; Region: PRK05481
1415784006296	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1415784006297	FeS/SAM binding site; other site
1415784006298	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1415784006299	Peptidase family M23; Region: Peptidase_M23; pfam01551
1415784006300	sporulation protein YunB; Region: spo_yunB; TIGR02832
1415784006301	Uncharacterized conserved protein [Function unknown]; Region: COG3377
1415784006302	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1415784006303	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
1415784006304	active site
1415784006305	metal binding site [ion binding]; metal-binding site
1415784006306	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1415784006307	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1415784006308	FeS assembly protein SufB; Region: sufB; TIGR01980
1415784006309	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1415784006310	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1415784006311	trimerization site [polypeptide binding]; other site
1415784006312	active site
1415784006313	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1415784006314	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1415784006315	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1415784006316	catalytic residue [active]
1415784006317	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1415784006318	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
1415784006319	FeS assembly protein SufD; Region: sufD; TIGR01981
1415784006320	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
1415784006321	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1415784006322	Walker A/P-loop; other site
1415784006323	ATP binding site [chemical binding]; other site
1415784006324	Q-loop/lid; other site
1415784006325	ABC transporter signature motif; other site
1415784006326	Walker B; other site
1415784006327	D-loop; other site
1415784006328	H-loop/switch region; other site
1415784006329	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1415784006330	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1415784006331	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1415784006332	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1415784006333	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784006334	ABC-ATPase subunit interface; other site
1415784006335	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
1415784006336	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1415784006337	Walker A/P-loop; other site
1415784006338	ATP binding site [chemical binding]; other site
1415784006339	Q-loop/lid; other site
1415784006340	ABC transporter signature motif; other site
1415784006341	Walker B; other site
1415784006342	D-loop; other site
1415784006343	H-loop/switch region; other site
1415784006344	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
1415784006345	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1415784006346	catalytic residues [active]
1415784006347	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
1415784006348	putative active site [active]
1415784006349	putative metal binding site [ion binding]; other site
1415784006350	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1415784006351	lipoyl attachment site [posttranslational modification]; other site
1415784006352	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
1415784006353	ArsC family; Region: ArsC; pfam03960
1415784006354	putative ArsC-like catalytic residues; other site
1415784006355	putative TRX-like catalytic residues [active]
1415784006356	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
1415784006357	active site
1415784006358	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
1415784006359	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1415784006360	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
1415784006361	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1415784006362	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1415784006363	NAD binding site [chemical binding]; other site
1415784006364	dimer interface [polypeptide binding]; other site
1415784006365	substrate binding site [chemical binding]; other site
1415784006366	Coat F domain; Region: Coat_F; pfam07875
1415784006367	CAAX protease self-immunity; Region: Abi; pfam02517
1415784006368	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1415784006369	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1415784006370	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1415784006371	active site
1415784006372	acetyl-CoA acetyltransferase; Provisional; Region: PRK07661
1415784006373	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1415784006374	dimer interface [polypeptide binding]; other site
1415784006375	active site
1415784006376	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
1415784006377	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1415784006378	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1415784006379	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1415784006380	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1415784006381	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1415784006382	substrate binding site [chemical binding]; other site
1415784006383	oxyanion hole (OAH) forming residues; other site
1415784006384	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1415784006385	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1415784006386	Proline dehydrogenase; Region: Pro_dh; cl03282
1415784006387	Protein of unknown function (DUF2573); Region: DUF2573; pfam10835
1415784006388	Domain of unknown function DUF77; Region: DUF77; pfam01910
1415784006389	Cache domain; Region: Cache_1; pfam02743
1415784006390	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1415784006391	dimerization interface [polypeptide binding]; other site
1415784006392	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1415784006393	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1415784006394	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1415784006395	dimer interface [polypeptide binding]; other site
1415784006396	putative CheW interface [polypeptide binding]; other site
1415784006397	Predicted transcriptional regulators [Transcription]; Region: COG1378
1415784006398	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
1415784006399	Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124
1415784006400	C-terminal domain interface [polypeptide binding]; other site
1415784006401	sugar binding site [chemical binding]; other site
1415784006402	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1415784006403	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784006404	putative substrate translocation pore; other site
1415784006405	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1415784006406	Spore germination protein; Region: Spore_permease; cl17796
1415784006407	Eisosome component PIL1; Region: Pil1; pfam13805
1415784006408	OxaA-like protein precursor; Validated; Region: PRK01622
1415784006409	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1415784006410	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1415784006411	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1415784006412	hypothetical protein; Provisional; Region: PRK06758
1415784006413	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709
1415784006414	active site
1415784006415	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1415784006416	non-specific DNA binding site [nucleotide binding]; other site
1415784006417	salt bridge; other site
1415784006418	sequence-specific DNA binding site [nucleotide binding]; other site
1415784006419	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1415784006420	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1415784006421	Protein of unknown function (DUF3978); Region: DUF3978; pfam13123
1415784006422	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1415784006423	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1415784006424	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1415784006425	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784006426	active site
1415784006427	phosphorylation site [posttranslational modification]
1415784006428	intermolecular recognition site; other site
1415784006429	dimerization interface [polypeptide binding]; other site
1415784006430	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1415784006431	DNA binding site [nucleotide binding]
1415784006432	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1415784006433	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1415784006434	dimer interface [polypeptide binding]; other site
1415784006435	phosphorylation site [posttranslational modification]
1415784006436	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784006437	ATP binding site [chemical binding]; other site
1415784006438	Mg2+ binding site [ion binding]; other site
1415784006439	G-X-G motif; other site
1415784006440	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1415784006441	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
1415784006442	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1415784006443	active site
1415784006444	HIGH motif; other site
1415784006445	KMSKS motif; other site
1415784006446	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1415784006447	tRNA binding surface [nucleotide binding]; other site
1415784006448	anticodon binding site; other site
1415784006449	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784006450	S-adenosylmethionine binding site [chemical binding]; other site
1415784006451	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1415784006452	dimerization interface [polypeptide binding]; other site
1415784006453	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1415784006454	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1415784006455	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1415784006456	dimer interface [polypeptide binding]; other site
1415784006457	putative CheW interface [polypeptide binding]; other site
1415784006458	CHASE3 domain; Region: CHASE3; cl05000
1415784006459	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1415784006460	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1415784006461	dimerization interface [polypeptide binding]; other site
1415784006462	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1415784006463	dimer interface [polypeptide binding]; other site
1415784006464	putative CheW interface [polypeptide binding]; other site
1415784006465	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1415784006466	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1415784006467	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
1415784006468	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1415784006469	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
1415784006470	active site
1415784006471	Zn binding site [ion binding]; other site
1415784006472	Pirin-related protein [General function prediction only]; Region: COG1741
1415784006473	Pirin; Region: Pirin; pfam02678
1415784006474	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1415784006475	MarR family; Region: MarR_2; pfam12802
1415784006476	Protein of unknown function (DUF3920); Region: DUF3920; pfam13058
1415784006477	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1415784006478	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1415784006479	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1415784006480	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1415784006481	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
1415784006482	TrkA-C domain; Region: TrkA_C; pfam02080
1415784006483	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1415784006484	amino acid carrier protein; Region: agcS; TIGR00835
1415784006485	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1415784006486	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1415784006487	dimerization interface [polypeptide binding]; other site
1415784006488	DPS ferroxidase diiron center [ion binding]; other site
1415784006489	ion pore; other site
1415784006490	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
1415784006491	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523
1415784006492	metal binding site [ion binding]; metal-binding site
1415784006493	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
1415784006494	Ferritin-like domain; Region: Ferritin; pfam00210
1415784006495	ferroxidase diiron center [ion binding]; other site
1415784006496	Predicted membrane protein [Function unknown]; Region: COG2311
1415784006497	Protein of unknown function (DUF418); Region: DUF418; cl12135
1415784006498	Protein of unknown function (DUF418); Region: DUF418; pfam04235
1415784006499	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1415784006500	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1415784006501	Nucleoside recognition; Region: Gate; pfam07670
1415784006502	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1415784006503	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1415784006504	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1415784006505	Nucleoside recognition; Region: Gate; pfam07670
1415784006506	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1415784006507	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1415784006508	amino acid carrier protein; Region: agcS; TIGR00835
1415784006509	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1415784006510	amino acid carrier protein; Region: agcS; TIGR00835
1415784006511	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
1415784006512	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1415784006513	NAD binding site [chemical binding]; other site
1415784006514	substrate binding site [chemical binding]; other site
1415784006515	putative active site [active]
1415784006516	TQXA domain; Region: TQXA_dom; TIGR03934
1415784006517	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1415784006518	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1415784006519	active site
1415784006520	catalytic tetrad [active]
1415784006521	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1415784006522	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784006523	putative substrate translocation pore; other site
1415784006524	Predicted transcriptional regulators [Transcription]; Region: COG1733
1415784006525	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1415784006526	dimerization interface [polypeptide binding]; other site
1415784006527	putative DNA binding site [nucleotide binding]; other site
1415784006528	putative Zn2+ binding site [ion binding]; other site
1415784006529	Uncharacterized conserved protein [Function unknown]; Region: COG2427
1415784006530	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1415784006531	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1415784006532	tyrosyl-tRNA synthetase; Provisional; Region: PRK13354
1415784006533	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1415784006534	active site
1415784006535	HIGH motif; other site
1415784006536	dimer interface [polypeptide binding]; other site
1415784006537	KMSKS motif; other site
1415784006538	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1415784006539	RNA binding surface [nucleotide binding]; other site
1415784006540	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK12436
1415784006541	FAD binding domain; Region: FAD_binding_4; pfam01565
1415784006542	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1415784006543	SET domain; Region: SET; pfam00856
1415784006544	Domain of unknown function (DUF4077); Region: DUF4077; pfam13295
1415784006545	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1415784006546	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1415784006547	dimer interface [polypeptide binding]; other site
1415784006548	putative CheW interface [polypeptide binding]; other site
1415784006549	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1415784006550	putative phosphate binding site [ion binding]; other site
1415784006551	camphor resistance protein CrcB; Provisional; Region: PRK14219
1415784006552	camphor resistance protein CrcB; Provisional; Region: PRK14205
1415784006553	Protein of unknown function (DUF3947); Region: DUF3947; pfam13135
1415784006554	Protein of unknown function (DUF3955); Region: DUF3955; pfam13127
1415784006555	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784006556	H+ Antiporter protein; Region: 2A0121; TIGR00900
1415784006557	putative substrate translocation pore; other site
1415784006558	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784006559	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1415784006560	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1415784006561	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1415784006562	ABC transporter; Region: ABC_tran_2; pfam12848
1415784006563	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1415784006564	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1415784006565	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784006566	Coenzyme A binding pocket [chemical binding]; other site
1415784006567	phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833
1415784006568	Nuclease-related domain; Region: NERD; pfam08378
1415784006569	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
1415784006570	Isochorismatase family; Region: Isochorismatase; pfam00857
1415784006571	catalytic triad [active]
1415784006572	conserved cis-peptide bond; other site
1415784006573	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1415784006574	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1415784006575	putative DNA binding site [nucleotide binding]; other site
1415784006576	putative Zn2+ binding site [ion binding]; other site
1415784006577	AsnC family; Region: AsnC_trans_reg; pfam01037
1415784006578	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1415784006579	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1415784006580	AsnC family; Region: AsnC_trans_reg; pfam01037
1415784006581	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
1415784006582	active site clefts [active]
1415784006583	zinc binding site [ion binding]; other site
1415784006584	dimer interface [polypeptide binding]; other site
1415784006585	cyanate hydratase; Validated; Region: PRK02866
1415784006586	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
1415784006587	oligomer interface [polypeptide binding]; other site
1415784006588	active site
1415784006589	putative uracil/xanthine transporter; Provisional; Region: PRK11412
1415784006590	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
1415784006591	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
1415784006592	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1415784006593	Walker A/P-loop; other site
1415784006594	ATP binding site [chemical binding]; other site
1415784006595	Q-loop/lid; other site
1415784006596	ABC transporter signature motif; other site
1415784006597	Walker B; other site
1415784006598	D-loop; other site
1415784006599	H-loop/switch region; other site
1415784006600	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1415784006601	ABC-ATPase subunit  interface; other site
1415784006602	dimer interface [polypeptide binding]; other site
1415784006603	putative PBP binding regions; other site
1415784006604	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1415784006605	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1415784006606	ABC-ATPase subunit  interface; other site
1415784006607	dimer interface [polypeptide binding]; other site
1415784006608	putative PBP binding regions; other site
1415784006609	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
1415784006610	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
1415784006611	putative ligand binding residues [chemical binding]; other site
1415784006612	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1415784006613	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784006614	active site
1415784006615	phosphorylation site [posttranslational modification]
1415784006616	intermolecular recognition site; other site
1415784006617	dimerization interface [polypeptide binding]; other site
1415784006618	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1415784006619	DNA binding site [nucleotide binding]
1415784006620	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1415784006621	SmpB-tmRNA interface; other site
1415784006622	ribonuclease R; Region: RNase_R; TIGR02063
1415784006623	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1415784006624	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1415784006625	RNB domain; Region: RNB; pfam00773
1415784006626	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
1415784006627	RNA binding site [nucleotide binding]; other site
1415784006628	Esterase/lipase [General function prediction only]; Region: COG1647
1415784006629	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
1415784006630	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
1415784006631	holin-like protein; Validated; Region: PRK01658
1415784006632	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455
1415784006633	active site
1415784006634	enolase; Provisional; Region: eno; PRK00077
1415784006635	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1415784006636	dimer interface [polypeptide binding]; other site
1415784006637	metal binding site [ion binding]; metal-binding site
1415784006638	substrate binding pocket [chemical binding]; other site
1415784006639	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
1415784006640	phosphoglyceromutase; Provisional; Region: PRK05434
1415784006641	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1415784006642	triosephosphate isomerase; Provisional; Region: PRK14565
1415784006643	substrate binding site [chemical binding]; other site
1415784006644	dimer interface [polypeptide binding]; other site
1415784006645	catalytic triad [active]
1415784006646	Phosphoglycerate kinase; Region: PGK; pfam00162
1415784006647	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1415784006648	substrate binding site [chemical binding]; other site
1415784006649	hinge regions; other site
1415784006650	ADP binding site [chemical binding]; other site
1415784006651	catalytic site [active]
1415784006652	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
1415784006653	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1415784006654	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1415784006655	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1415784006656	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1415784006657	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
1415784006658	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
1415784006659	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
1415784006660	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
1415784006661	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
1415784006662	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
1415784006663	Protein of unknown function (DUF1093); Region: DUF1093; cl02185
1415784006664	Protein of unknown function (DUF1657); Region: DUF1657; pfam07870
1415784006665	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
1415784006666	stage V sporulation protein AC; Region: spore_V_AC; TIGR02838
1415784006667	stage V sporulation protein AD; Provisional; Region: PRK12404
1415784006668	Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451
1415784006669	stage V sporulation protein AE; Region: spore_V_AE; TIGR02839
1415784006670	Protein of unknown function (DUF1657); Region: DUF1657; pfam07870
1415784006671	Predicted membrane protein [Function unknown]; Region: COG2323
1415784006672	Protein of unknown function (DUF1657); Region: DUF1657; pfam07870
1415784006673	Clp protease; Region: CLP_protease; pfam00574
1415784006674	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1415784006675	oligomer interface [polypeptide binding]; other site
1415784006676	active site residues [active]
1415784006677	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1415784006678	dimerization domain swap beta strand [polypeptide binding]; other site
1415784006679	regulatory protein interface [polypeptide binding]; other site
1415784006680	active site
1415784006681	regulatory phosphorylation site [posttranslational modification]; other site
1415784006682	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
1415784006683	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
1415784006684	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
1415784006685	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
1415784006686	phosphate binding site [ion binding]; other site
1415784006687	putative substrate binding pocket [chemical binding]; other site
1415784006688	dimer interface [polypeptide binding]; other site
1415784006689	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
1415784006690	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
1415784006691	putative active site [active]
1415784006692	nucleotide binding site [chemical binding]; other site
1415784006693	nudix motif; other site
1415784006694	putative metal binding site [ion binding]; other site
1415784006695	Domain of unknown function (DUF368); Region: DUF368; pfam04018
1415784006696	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1415784006697	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1415784006698	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1415784006699	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1415784006700	binding surface
1415784006701	TPR motif; other site
1415784006702	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1415784006703	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1415784006704	binding surface
1415784006705	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1415784006706	TPR motif; other site
1415784006707	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1415784006708	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
1415784006709	trimer interface [polypeptide binding]; other site
1415784006710	active site
1415784006711	substrate binding site [chemical binding]; other site
1415784006712	CoA binding site [chemical binding]; other site
1415784006713	pyrophosphatase PpaX; Provisional; Region: PRK13288
1415784006714	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1415784006715	active site
1415784006716	motif I; other site
1415784006717	motif II; other site
1415784006718	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
1415784006719	HPr kinase/phosphorylase; Provisional; Region: PRK05428
1415784006720	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
1415784006721	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
1415784006722	Hpr binding site; other site
1415784006723	active site
1415784006724	homohexamer subunit interaction site [polypeptide binding]; other site
1415784006725	Predicted membrane protein [Function unknown]; Region: COG1950
1415784006726	Domain of unknown function (DUF4275); Region: DUF4275; pfam14101
1415784006727	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1415784006728	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1415784006729	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1415784006730	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1415784006731	excinuclease ABC subunit B; Provisional; Region: PRK05298
1415784006732	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1415784006733	ATP binding site [chemical binding]; other site
1415784006734	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1415784006735	nucleotide binding region [chemical binding]; other site
1415784006736	ATP-binding site [chemical binding]; other site
1415784006737	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1415784006738	Domain of unknown function (DUF4362); Region: DUF4362; pfam14275
1415784006739	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
1415784006740	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1415784006741	DNA binding residues [nucleotide binding]
1415784006742	dimer interface [polypeptide binding]; other site
1415784006743	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
1415784006744	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1415784006745	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1415784006746	non-specific DNA binding site [nucleotide binding]; other site
1415784006747	salt bridge; other site
1415784006748	sequence-specific DNA binding site [nucleotide binding]; other site
1415784006749	Predicted membrane protein [Function unknown]; Region: COG2855
1415784006750	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1415784006751	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1415784006752	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
1415784006753	putative dimerization interface [polypeptide binding]; other site
1415784006754	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282
1415784006755	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1415784006756	DNA binding residues [nucleotide binding]
1415784006757	putative dimer interface [polypeptide binding]; other site
1415784006758	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1415784006759	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1415784006760	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1415784006761	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1415784006762	ABC transporter; Region: ABC_tran_2; pfam12848
1415784006763	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1415784006764	hypothetical protein; Provisional; Region: PRK12855
1415784006765	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1415784006766	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1415784006767	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1415784006768	Walker A/P-loop; other site
1415784006769	ATP binding site [chemical binding]; other site
1415784006770	Q-loop/lid; other site
1415784006771	ABC transporter signature motif; other site
1415784006772	Walker B; other site
1415784006773	D-loop; other site
1415784006774	H-loop/switch region; other site
1415784006775	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1415784006776	protein binding site [polypeptide binding]; other site
1415784006777	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1415784006778	C-terminal peptidase (prc); Region: prc; TIGR00225
1415784006779	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1415784006780	protein binding site [polypeptide binding]; other site
1415784006781	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1415784006782	Catalytic dyad [active]
1415784006783	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1415784006784	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
1415784006785	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
1415784006786	FtsX-like permease family; Region: FtsX; pfam02687
1415784006787	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
1415784006788	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1415784006789	Walker A/P-loop; other site
1415784006790	ATP binding site [chemical binding]; other site
1415784006791	Q-loop/lid; other site
1415784006792	ABC transporter signature motif; other site
1415784006793	Walker B; other site
1415784006794	D-loop; other site
1415784006795	H-loop/switch region; other site
1415784006796	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1415784006797	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1415784006798	peptide chain release factor 2; Provisional; Region: PRK06746
1415784006799	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1415784006800	RF-1 domain; Region: RF-1; pfam00472
1415784006801	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1415784006802	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1415784006803	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
1415784006804	nucleotide binding region [chemical binding]; other site
1415784006805	ATP-binding site [chemical binding]; other site
1415784006806	SEC-C motif; Region: SEC-C; pfam02810
1415784006807	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1415784006808	30S subunit binding site; other site
1415784006809	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1415784006810	DNA-binding site [nucleotide binding]; DNA binding site
1415784006811	RNA-binding motif; other site
1415784006812	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
1415784006813	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1415784006814	active site
1415784006815	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
1415784006816	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1415784006817	ATP binding site [chemical binding]; other site
1415784006818	putative Mg++ binding site [ion binding]; other site
1415784006819	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1415784006820	nucleotide binding region [chemical binding]; other site
1415784006821	ATP-binding site [chemical binding]; other site
1415784006822	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
1415784006823	Cortexillin I, coiled coil; Region: Cortex-I_coil; pfam09304
1415784006824	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1415784006825	NlpC/P60 family; Region: NLPC_P60; pfam00877
1415784006826	Predicted transcriptional regulators [Transcription]; Region: COG1733
1415784006827	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1415784006828	dimerization interface [polypeptide binding]; other site
1415784006829	putative DNA binding site [nucleotide binding]; other site
1415784006830	putative Zn2+ binding site [ion binding]; other site
1415784006831	EDD domain protein, DegV family; Region: DegV; TIGR00762
1415784006832	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1415784006833	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1415784006834	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1415784006835	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1415784006836	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1415784006837	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
1415784006838	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1415784006839	active site
1415784006840	homodimer interface [polypeptide binding]; other site
1415784006841	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1415784006842	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1415784006843	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1415784006844	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
1415784006845	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
1415784006846	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1415784006847	Mg++ binding site [ion binding]; other site
1415784006848	putative catalytic motif [active]
1415784006849	substrate binding site [chemical binding]; other site
1415784006850	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1415784006851	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
1415784006852	NodB motif; other site
1415784006853	active site
1415784006854	catalytic site [active]
1415784006855	Zn binding site [ion binding]; other site
1415784006856	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1415784006857	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1415784006858	Walker A motif; other site
1415784006859	ATP binding site [chemical binding]; other site
1415784006860	Walker B motif; other site
1415784006861	arginine finger; other site
1415784006862	Transcriptional antiterminator [Transcription]; Region: COG3933
1415784006863	PRD domain; Region: PRD; pfam00874
1415784006864	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1415784006865	active pocket/dimerization site; other site
1415784006866	active site
1415784006867	phosphorylation site [posttranslational modification]
1415784006868	PRD domain; Region: PRD; pfam00874
1415784006869	CHRD domain; Region: CHRD; pfam07452
1415784006870	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
1415784006871	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
1415784006872	Chromate transporter; Region: Chromate_transp; pfam02417
1415784006873	Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803
1415784006874	putative active site [active]
1415784006875	YdjC motif; other site
1415784006876	Mg binding site [ion binding]; other site
1415784006877	putative homodimer interface [polypeptide binding]; other site
1415784006878	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
1415784006879	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
1415784006880	NAD binding site [chemical binding]; other site
1415784006881	sugar binding site [chemical binding]; other site
1415784006882	divalent metal binding site [ion binding]; other site
1415784006883	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1415784006884	dimer interface [polypeptide binding]; other site
1415784006885	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1415784006886	active site
1415784006887	methionine cluster; other site
1415784006888	phosphorylation site [posttranslational modification]
1415784006889	metal binding site [ion binding]; metal-binding site
1415784006890	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1415784006891	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1415784006892	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1415784006893	active site
1415784006894	P-loop; other site
1415784006895	phosphorylation site [posttranslational modification]
1415784006896	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1415784006897	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784006898	S-adenosylmethionine binding site [chemical binding]; other site
1415784006899	S-adenosylmethionine decarboxylase proenzyme; Validated; Region: PRK01706
1415784006900	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1415784006901	methionine cluster; other site
1415784006902	active site
1415784006903	phosphorylation site [posttranslational modification]
1415784006904	metal binding site [ion binding]; metal-binding site
1415784006905	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1415784006906	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295
1415784006907	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1415784006908	active site
1415784006909	P-loop; other site
1415784006910	phosphorylation site [posttranslational modification]
1415784006911	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
1415784006912	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1415784006913	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1415784006914	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
1415784006915	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1415784006916	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
1415784006917	Predicted membrane protein [Function unknown]; Region: COG1511
1415784006918	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1415784006919	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
1415784006920	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1415784006921	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1415784006922	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1415784006923	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
1415784006924	putative dimerization interface [polypeptide binding]; other site
1415784006925	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1415784006926	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
1415784006927	arsenical pump membrane protein; Provisional; Region: PRK15445
1415784006928	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
1415784006929	transmembrane helices; other site
1415784006930	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
1415784006931	ThiC-associated domain; Region: ThiC-associated; pfam13667
1415784006932	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
1415784006933	L-lactate permease; Region: Lactate_perm; cl00701
1415784006934	glycolate transporter; Provisional; Region: PRK09695
1415784006935	Tic20-like protein; Region: Tic20; pfam09685
1415784006936	Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988
1415784006937	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
1415784006938	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1415784006939	Sulfatase; Region: Sulfatase; pfam00884
1415784006940	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1415784006941	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
1415784006942	homodimer interface [polypeptide binding]; other site
1415784006943	substrate-cofactor binding pocket; other site
1415784006944	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784006945	catalytic residue [active]
1415784006946	Bacterial SH3 domain; Region: SH3_3; pfam08239
1415784006947	Bacterial SH3 domain; Region: SH3_3; pfam08239
1415784006948	Bacterial SH3 domain; Region: SH3_3; pfam08239
1415784006949	Bacterial SH3 domain; Region: SH3_3; pfam08239
1415784006950	Bacterial SH3 domain; Region: SH3_3; pfam08239
1415784006951	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1415784006952	NlpC/P60 family; Region: NLPC_P60; pfam00877
1415784006953	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1415784006954	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1415784006955	Nucleoside recognition; Region: Gate; pfam07670
1415784006956	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1415784006957	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
1415784006958	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
1415784006959	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1415784006960	DXD motif; other site
1415784006961	BCCT family transporter; Region: BCCT; pfam02028
1415784006962	Bacterial SH3 domain; Region: SH3_3; pfam08239
1415784006963	Bacterial SH3 domain; Region: SH3_3; pfam08239
1415784006964	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
1415784006965	Protein of unknown function (DUF3910); Region: DUF3910; pfam13049
1415784006966	SNF2 Helicase protein; Region: DUF3670; pfam12419
1415784006967	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
1415784006968	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1415784006969	ATP binding site [chemical binding]; other site
1415784006970	putative Mg++ binding site [ion binding]; other site
1415784006971	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1415784006972	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1415784006973	nucleotide binding region [chemical binding]; other site
1415784006974	ATP-binding site [chemical binding]; other site
1415784006975	Predicted integral membrane protein [Function unknown]; Region: COG5652
1415784006976	Protein of unknown function (DUF1659); Region: DUF1659; pfam07872
1415784006977	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
1415784006978	Domain of unknown function (DUF4359); Region: DUF4359; pfam14271
1415784006979	ComK protein; Region: ComK; cl11560
1415784006980	RNA polymerase factor sigma-70; Validated; Region: PRK06759
1415784006981	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1415784006982	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1415784006983	DNA binding residues [nucleotide binding]
1415784006984	Yip1 domain; Region: Yip1; cl17815
1415784006985	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1415784006986	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1415784006987	FtsX-like permease family; Region: FtsX; pfam02687
1415784006988	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1415784006989	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1415784006990	Walker A/P-loop; other site
1415784006991	ATP binding site [chemical binding]; other site
1415784006992	Q-loop/lid; other site
1415784006993	ABC transporter signature motif; other site
1415784006994	Walker B; other site
1415784006995	D-loop; other site
1415784006996	H-loop/switch region; other site
1415784006997	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1415784006998	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1415784006999	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
1415784007000	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784007001	putative substrate translocation pore; other site
1415784007002	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1415784007003	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
1415784007004	Protein of unknown function (DUF3919); Region: DUF3919; pfam13057
1415784007005	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1415784007006	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1415784007007	dimerization interface [polypeptide binding]; other site
1415784007008	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1415784007009	dimer interface [polypeptide binding]; other site
1415784007010	phosphorylation site [posttranslational modification]
1415784007011	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784007012	ATP binding site [chemical binding]; other site
1415784007013	Mg2+ binding site [ion binding]; other site
1415784007014	G-X-G motif; other site
1415784007015	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1415784007016	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784007017	active site
1415784007018	phosphorylation site [posttranslational modification]
1415784007019	intermolecular recognition site; other site
1415784007020	dimerization interface [polypeptide binding]; other site
1415784007021	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1415784007022	DNA binding site [nucleotide binding]
1415784007023	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
1415784007024	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1415784007025	NAD binding site [chemical binding]; other site
1415784007026	homodimer interface [polypeptide binding]; other site
1415784007027	active site
1415784007028	substrate binding site [chemical binding]; other site
1415784007029	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1415784007030	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
1415784007031	active site
1415784007032	metal-binding site
1415784007033	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1415784007034	EamA-like transporter family; Region: EamA; cl17759
1415784007035	EamA-like transporter family; Region: EamA; cl17759
1415784007036	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1415784007037	putative DNA binding site [nucleotide binding]; other site
1415784007038	putative Zn2+ binding site [ion binding]; other site
1415784007039	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1415784007040	active site
1415784007041	Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151
1415784007042	Phosphotransferase enzyme family; Region: APH; pfam01636
1415784007043	active site
1415784007044	substrate binding site [chemical binding]; other site
1415784007045	ATP binding site [chemical binding]; other site
1415784007046	dimer interface [polypeptide binding]; other site
1415784007047	LicD family; Region: LicD; pfam04991
1415784007048	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
1415784007049	membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379
1415784007050	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
1415784007051	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1415784007052	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1415784007053	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1415784007054	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1415784007055	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
1415784007056	putative ADP-binding pocket [chemical binding]; other site
1415784007057	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1415784007058	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1415784007059	active site
1415784007060	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1415784007061	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
1415784007062	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1415784007063	Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513
1415784007064	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1415784007065	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1415784007066	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1415784007067	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1415784007068	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1415784007069	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1415784007070	active site
1415784007071	tetramer interface; other site
1415784007072	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
1415784007073	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1415784007074	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1415784007075	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
1415784007076	Chain length determinant protein; Region: Wzz; cl15801
1415784007077	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1415784007078	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1415784007079	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1415784007080	rod shape-determining protein Mbl; Provisional; Region: PRK13928
1415784007081	MreB and similar proteins; Region: MreB_like; cd10225
1415784007082	nucleotide binding site [chemical binding]; other site
1415784007083	Mg binding site [ion binding]; other site
1415784007084	putative protofilament interaction site [polypeptide binding]; other site
1415784007085	RodZ interaction site [polypeptide binding]; other site
1415784007086	Stage III sporulation protein D; Region: SpoIIID; cl17560
1415784007087	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1415784007088	Peptidase family M23; Region: Peptidase_M23; pfam01551
1415784007089	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1415784007090	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1415784007091	Walker A/P-loop; other site
1415784007092	ATP binding site [chemical binding]; other site
1415784007093	Q-loop/lid; other site
1415784007094	ABC transporter signature motif; other site
1415784007095	Walker B; other site
1415784007096	D-loop; other site
1415784007097	H-loop/switch region; other site
1415784007098	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1415784007099	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1415784007100	Walker A/P-loop; other site
1415784007101	ATP binding site [chemical binding]; other site
1415784007102	Q-loop/lid; other site
1415784007103	ABC transporter signature motif; other site
1415784007104	Walker B; other site
1415784007105	D-loop; other site
1415784007106	H-loop/switch region; other site
1415784007107	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1415784007108	LytTr DNA-binding domain; Region: LytTR; pfam04397
1415784007109	Stage II sporulation protein; Region: SpoIID; pfam08486
1415784007110	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
1415784007111	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1415784007112	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1415784007113	hinge; other site
1415784007114	active site
1415784007115	Protein of unknown function (DUF1779); Region: DUF1779; pfam08680
1415784007116	Protein of unknown function (DUF1146); Region: DUF1146; cl11486
1415784007117	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
1415784007118	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1415784007119	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
1415784007120	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1415784007121	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
1415784007122	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
1415784007123	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1415784007124	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
1415784007125	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
1415784007126	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
1415784007127	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
1415784007128	4Fe-4S binding domain; Region: Fer4; cl02805
1415784007129	4Fe-4S binding domain; Region: Fer4; pfam00037
1415784007130	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
1415784007131	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
1415784007132	NADH dehydrogenase subunit D; Provisional; Region: PRK12322
1415784007133	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
1415784007134	NADH dehydrogenase subunit C; Validated; Region: PRK07735
1415784007135	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
1415784007136	NADH dehydrogenase subunit B; Validated; Region: PRK06411
1415784007137	NADH dehydrogenase subunit A; Validated; Region: PRK07756
1415784007138	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1415784007139	PAS domain; Region: PAS_9; pfam13426
1415784007140	putative active site [active]
1415784007141	heme pocket [chemical binding]; other site
1415784007142	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1415784007143	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1415784007144	metal binding site [ion binding]; metal-binding site
1415784007145	active site
1415784007146	I-site; other site
1415784007147	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1415784007148	Protein of unknown function (DUF975); Region: DUF975; cl10504
1415784007149	Protein of unknown function (DUF975); Region: DUF975; cl10504
1415784007150	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
1415784007151	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1415784007152	gamma subunit interface [polypeptide binding]; other site
1415784007153	epsilon subunit interface [polypeptide binding]; other site
1415784007154	LBP interface [polypeptide binding]; other site
1415784007155	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1415784007156	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1415784007157	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1415784007158	alpha subunit interaction interface [polypeptide binding]; other site
1415784007159	Walker A motif; other site
1415784007160	ATP binding site [chemical binding]; other site
1415784007161	Walker B motif; other site
1415784007162	inhibitor binding site; inhibition site
1415784007163	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1415784007164	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1415784007165	core domain interface [polypeptide binding]; other site
1415784007166	delta subunit interface [polypeptide binding]; other site
1415784007167	epsilon subunit interface [polypeptide binding]; other site
1415784007168	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1415784007169	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1415784007170	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1415784007171	beta subunit interaction interface [polypeptide binding]; other site
1415784007172	Walker A motif; other site
1415784007173	ATP binding site [chemical binding]; other site
1415784007174	Walker B motif; other site
1415784007175	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1415784007176	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
1415784007177	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1415784007178	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1415784007179	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1415784007180	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
1415784007181	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1415784007182	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1415784007183	ATP synthase I chain; Region: ATP_synt_I; pfam03899
1415784007184	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
1415784007185	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1415784007186	active site
1415784007187	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1415784007188	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1415784007189	dimer interface [polypeptide binding]; other site
1415784007190	active site
1415784007191	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1415784007192	folate binding site [chemical binding]; other site
1415784007193	hypothetical protein; Provisional; Region: PRK13690
1415784007194	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
1415784007195	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1415784007196	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1415784007197	active site
1415784007198	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1415784007199	HPr interaction site; other site
1415784007200	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1415784007201	active site
1415784007202	phosphorylation site [posttranslational modification]
1415784007203	Predicted membrane protein [Function unknown]; Region: COG2259
1415784007204	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1415784007205	Protein of unknown function (DUF3935); Region: DUF3935; pfam13071
1415784007206	Predicted membrane protein [Function unknown]; Region: COG1971
1415784007207	Domain of unknown function DUF; Region: DUF204; pfam02659
1415784007208	Domain of unknown function DUF; Region: DUF204; pfam02659
1415784007209	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1415784007210	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
1415784007211	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1415784007212	Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551
1415784007213	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1415784007214	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784007215	S-adenosylmethionine binding site [chemical binding]; other site
1415784007216	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1415784007217	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1415784007218	RF-1 domain; Region: RF-1; pfam00472
1415784007219	thymidine kinase; Provisional; Region: PRK04296
1415784007220	LabA_like proteins; Region: LabA_like/DUF88; cl10034
1415784007221	putative metal binding site [ion binding]; other site
1415784007222	transcription termination factor Rho; Provisional; Region: rho; PRK09376
1415784007223	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
1415784007224	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
1415784007225	RNA binding site [nucleotide binding]; other site
1415784007226	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1415784007227	multimer interface [polypeptide binding]; other site
1415784007228	Walker A motif; other site
1415784007229	ATP binding site [chemical binding]; other site
1415784007230	Walker B motif; other site
1415784007231	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
1415784007232	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
1415784007233	putative active site [active]
1415784007234	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1415784007235	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1415784007236	hinge; other site
1415784007237	active site
1415784007238	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1415784007239	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1415784007240	intersubunit interface [polypeptide binding]; other site
1415784007241	active site
1415784007242	zinc binding site [ion binding]; other site
1415784007243	Na+ binding site [ion binding]; other site
1415784007244	Response regulator receiver domain; Region: Response_reg; pfam00072
1415784007245	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784007246	active site
1415784007247	phosphorylation site [posttranslational modification]
1415784007248	intermolecular recognition site; other site
1415784007249	dimerization interface [polypeptide binding]; other site
1415784007250	Protein of unknown function (DUF2529); Region: DUF2529; pfam10740
1415784007251	CTP synthetase; Validated; Region: pyrG; PRK05380
1415784007252	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1415784007253	Catalytic site [active]
1415784007254	active site
1415784007255	UTP binding site [chemical binding]; other site
1415784007256	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1415784007257	active site
1415784007258	putative oxyanion hole; other site
1415784007259	catalytic triad [active]
1415784007260	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
1415784007261	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1415784007262	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1415784007263	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1415784007264	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
1415784007265	FAD binding site [chemical binding]; other site
1415784007266	homotetramer interface [polypeptide binding]; other site
1415784007267	substrate binding pocket [chemical binding]; other site
1415784007268	catalytic base [active]
1415784007269	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1415784007270	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
1415784007271	FAD binding site [chemical binding]; other site
1415784007272	homotetramer interface [polypeptide binding]; other site
1415784007273	substrate binding pocket [chemical binding]; other site
1415784007274	catalytic base [active]
1415784007275	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
1415784007276	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1415784007277	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1415784007278	acetyl-CoA acetyltransferase; Provisional; Region: PRK08235
1415784007279	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1415784007280	dimer interface [polypeptide binding]; other site
1415784007281	active site
1415784007282	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1415784007283	4Fe-4S binding domain; Region: Fer4; cl02805
1415784007284	Cysteine-rich domain; Region: CCG; pfam02754
1415784007285	Cysteine-rich domain; Region: CCG; pfam02754
1415784007286	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1415784007287	PLD-like domain; Region: PLDc_2; pfam13091
1415784007288	putative active site [active]
1415784007289	catalytic site [active]
1415784007290	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1415784007291	PLD-like domain; Region: PLDc_2; pfam13091
1415784007292	putative active site [active]
1415784007293	catalytic site [active]
1415784007294	putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308
1415784007295	Domain of unknown function (DUF4084); Region: DUF4084; pfam13321
1415784007296	PAS domain S-box; Region: sensory_box; TIGR00229
1415784007297	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1415784007298	putative active site [active]
1415784007299	heme pocket [chemical binding]; other site
1415784007300	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1415784007301	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1415784007302	metal binding site [ion binding]; metal-binding site
1415784007303	active site
1415784007304	I-site; other site
1415784007305	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1415784007306	Bacillus PapR protein; Region: Bacillus_PapR; pfam05968
1415784007307	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1415784007308	non-specific DNA binding site [nucleotide binding]; other site
1415784007309	salt bridge; other site
1415784007310	sequence-specific DNA binding site [nucleotide binding]; other site
1415784007311	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1415784007312	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1415784007313	TPR motif; other site
1415784007314	binding surface
1415784007315	TPR repeat; Region: TPR_11; pfam13414
1415784007316	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1415784007317	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
1415784007318	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
1415784007319	active site
1415784007320	Zn binding site [ion binding]; other site
1415784007321	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1415784007322	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784007323	active site
1415784007324	phosphorylation site [posttranslational modification]
1415784007325	intermolecular recognition site; other site
1415784007326	dimerization interface [polypeptide binding]; other site
1415784007327	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1415784007328	DNA binding residues [nucleotide binding]
1415784007329	dimerization interface [polypeptide binding]; other site
1415784007330	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
1415784007331	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1415784007332	Histidine kinase; Region: HisKA_3; pfam07730
1415784007333	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1415784007334	Mg2+ binding site [ion binding]; other site
1415784007335	G-X-G motif; other site
1415784007336	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
1415784007337	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1415784007338	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1415784007339	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1415784007340	Walker A/P-loop; other site
1415784007341	ATP binding site [chemical binding]; other site
1415784007342	Q-loop/lid; other site
1415784007343	ABC transporter signature motif; other site
1415784007344	Walker B; other site
1415784007345	D-loop; other site
1415784007346	H-loop/switch region; other site
1415784007347	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1415784007348	active site
1415784007349	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1415784007350	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538
1415784007351	PA/protease or protease-like domain interface [polypeptide binding]; other site
1415784007352	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
1415784007353	Peptidase family M28; Region: Peptidase_M28; pfam04389
1415784007354	metal binding site [ion binding]; metal-binding site
1415784007355	Collagen binding domain; Region: Collagen_bind; pfam05737
1415784007356	Cna protein B-type domain; Region: Cna_B; pfam05738
1415784007357	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
1415784007358	domain interaction interfaces [polypeptide binding]; other site
1415784007359	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
1415784007360	domain interaction interfaces [polypeptide binding]; other site
1415784007361	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
1415784007362	domain interaction interfaces [polypeptide binding]; other site
1415784007363	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
1415784007364	domain interaction interfaces [polypeptide binding]; other site
1415784007365	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
1415784007366	domain interaction interfaces [polypeptide binding]; other site
1415784007367	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
1415784007368	domain interaction interfaces [polypeptide binding]; other site
1415784007369	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
1415784007370	domain interaction interfaces [polypeptide binding]; other site
1415784007371	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
1415784007372	domain interaction interfaces [polypeptide binding]; other site
1415784007373	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
1415784007374	domain interaction interfaces [polypeptide binding]; other site
1415784007375	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
1415784007376	domain interaction interfaces [polypeptide binding]; other site
1415784007377	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
1415784007378	domain interaction interfaces [polypeptide binding]; other site
1415784007379	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
1415784007380	domain interaction interfaces [polypeptide binding]; other site
1415784007381	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
1415784007382	domain interaction interfaces [polypeptide binding]; other site
1415784007383	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
1415784007384	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1415784007385	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1415784007386	active site
1415784007387	HIGH motif; other site
1415784007388	KMSK motif region; other site
1415784007389	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1415784007390	tRNA binding surface [nucleotide binding]; other site
1415784007391	anticodon binding site; other site
1415784007392	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
1415784007393	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
1415784007394	putative dimer interface [polypeptide binding]; other site
1415784007395	catalytic triad [active]
1415784007396	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
1415784007397	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1415784007398	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
1415784007399	agmatinase; Region: agmatinase; TIGR01230
1415784007400	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
1415784007401	putative active site [active]
1415784007402	Mn binding site [ion binding]; other site
1415784007403	spermidine synthase; Provisional; Region: PRK00811
1415784007404	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784007405	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784007406	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1415784007407	putative substrate translocation pore; other site
1415784007408	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1415784007409	Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774
1415784007410	DNA binding residues [nucleotide binding]
1415784007411	putative dimer interface [polypeptide binding]; other site
1415784007412	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1415784007413	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
1415784007414	active site
1415784007415	catalytic site [active]
1415784007416	metal binding site [ion binding]; metal-binding site
1415784007417	dimer interface [polypeptide binding]; other site
1415784007418	Transglycosylase; Region: Transgly; pfam00912
1415784007419	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1415784007420	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1415784007421	YwhD family; Region: YwhD; pfam08741
1415784007422	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
1415784007423	Peptidase family M50; Region: Peptidase_M50; pfam02163
1415784007424	active site
1415784007425	putative substrate binding region [chemical binding]; other site
1415784007426	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491
1415784007427	active site 1 [active]
1415784007428	dimer interface [polypeptide binding]; other site
1415784007429	hexamer interface [polypeptide binding]; other site
1415784007430	active site 2 [active]
1415784007431	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
1415784007432	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1415784007433	Zn2+ binding site [ion binding]; other site
1415784007434	Mg2+ binding site [ion binding]; other site
1415784007435	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1415784007436	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1415784007437	intersubunit interface [polypeptide binding]; other site
1415784007438	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1415784007439	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1415784007440	Walker A/P-loop; other site
1415784007441	ATP binding site [chemical binding]; other site
1415784007442	Q-loop/lid; other site
1415784007443	ABC transporter signature motif; other site
1415784007444	Walker B; other site
1415784007445	D-loop; other site
1415784007446	H-loop/switch region; other site
1415784007447	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1415784007448	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1415784007449	ABC-ATPase subunit  interface; other site
1415784007450	dimer interface [polypeptide binding]; other site
1415784007451	putative PBP binding regions; other site
1415784007452	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1415784007453	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1415784007454	ABC-ATPase subunit  interface; other site
1415784007455	dimer interface [polypeptide binding]; other site
1415784007456	putative PBP binding regions; other site
1415784007457	Protein of unknown function (DUF1450); Region: DUF1450; cl11488
1415784007458	putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923
1415784007459	transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894
1415784007460	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1415784007461	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
1415784007462	putative heme peroxidase; Provisional; Region: PRK12276
1415784007463	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1415784007464	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1415784007465	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
1415784007466	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
1415784007467	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
1415784007468	Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671
1415784007469	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
1415784007470	Ion channel; Region: Ion_trans_2; pfam07885
1415784007471	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1415784007472	TrkA-N domain; Region: TrkA_N; pfam02254
1415784007473	TrkA-C domain; Region: TrkA_C; pfam02080
1415784007474	putative uracil/xanthine transporter; Provisional; Region: PRK11412
1415784007475	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1415784007476	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1415784007477	motif II; other site
1415784007478	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1415784007479	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
1415784007480	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1415784007481	ligand binding site [chemical binding]; other site
1415784007482	active site
1415784007483	UGI interface [polypeptide binding]; other site
1415784007484	catalytic site [active]
1415784007485	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1415784007486	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
1415784007487	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
1415784007488	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1415784007489	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
1415784007490	Walker A/P-loop; other site
1415784007491	ATP binding site [chemical binding]; other site
1415784007492	Q-loop/lid; other site
1415784007493	ABC transporter signature motif; other site
1415784007494	Walker B; other site
1415784007495	D-loop; other site
1415784007496	H-loop/switch region; other site
1415784007497	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
1415784007498	active site
1415784007499	catalytic triad [active]
1415784007500	oxyanion hole [active]
1415784007501	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1415784007502	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1415784007503	DNA binding site [nucleotide binding]
1415784007504	domain linker motif; other site
1415784007505	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
1415784007506	putative dimerization interface [polypeptide binding]; other site
1415784007507	putative ligand binding site [chemical binding]; other site
1415784007508	Predicted membrane protein [Function unknown]; Region: COG2364
1415784007509	homoserine dehydrogenase; Provisional; Region: PRK06349
1415784007510	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1415784007511	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1415784007512	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
1415784007513	Homoserine O-succinyltransferase; Region: HTS; pfam04204
1415784007514	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
1415784007515	proposed active site lysine [active]
1415784007516	conserved cys residue [active]
1415784007517	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06702
1415784007518	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1415784007519	homodimer interface [polypeptide binding]; other site
1415784007520	substrate-cofactor binding pocket; other site
1415784007521	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784007522	catalytic residue [active]
1415784007523	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1415784007524	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
1415784007525	Cl- selectivity filter; other site
1415784007526	Cl- binding residues [ion binding]; other site
1415784007527	pore gating glutamate residue; other site
1415784007528	dimer interface [polypeptide binding]; other site
1415784007529	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
1415784007530	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1415784007531	active site
1415784007532	motif I; other site
1415784007533	motif II; other site
1415784007534	DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402
1415784007535	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1415784007536	ligand binding site [chemical binding]; other site
1415784007537	flexible hinge region; other site
1415784007538	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
1415784007539	azoreductase; Provisional; Region: PRK13556
1415784007540	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1415784007541	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784007542	active site
1415784007543	phosphorylation site [posttranslational modification]
1415784007544	intermolecular recognition site; other site
1415784007545	dimerization interface [polypeptide binding]; other site
1415784007546	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1415784007547	DNA binding residues [nucleotide binding]
1415784007548	dimerization interface [polypeptide binding]; other site
1415784007549	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1415784007550	GAF domain; Region: GAF; pfam01590
1415784007551	GAF domain; Region: GAF_3; pfam13492
1415784007552	GAF domain; Region: GAF_2; pfam13185
1415784007553	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1415784007554	Histidine kinase; Region: HisKA_3; pfam07730
1415784007555	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1415784007556	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1415784007557	dimer interface [polypeptide binding]; other site
1415784007558	substrate binding site [chemical binding]; other site
1415784007559	ATP binding site [chemical binding]; other site
1415784007560	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1415784007561	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1415784007562	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1415784007563	metal binding site [ion binding]; metal-binding site
1415784007564	active site
1415784007565	I-site; other site
1415784007566	Protein of unknown function (DUF466); Region: DUF466; pfam04328
1415784007567	carbon starvation protein A; Provisional; Region: PRK15015
1415784007568	Carbon starvation protein CstA; Region: CstA; pfam02554
1415784007569	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
1415784007570	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1415784007571	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784007572	active site
1415784007573	phosphorylation site [posttranslational modification]
1415784007574	intermolecular recognition site; other site
1415784007575	dimerization interface [polypeptide binding]; other site
1415784007576	LytTr DNA-binding domain; Region: LytTR; pfam04397
1415784007577	benzoate transport; Region: 2A0115; TIGR00895
1415784007578	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784007579	putative substrate translocation pore; other site
1415784007580	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
1415784007581	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
1415784007582	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1415784007583	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1415784007584	Predicted membrane protein [Function unknown]; Region: COG2860
1415784007585	UPF0126 domain; Region: UPF0126; pfam03458
1415784007586	UPF0126 domain; Region: UPF0126; pfam03458
1415784007587	Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide,  which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068
1415784007588	heme-binding site [chemical binding]; other site
1415784007589	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1415784007590	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1415784007591	dimer interface [polypeptide binding]; other site
1415784007592	putative CheW interface [polypeptide binding]; other site
1415784007593	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
1415784007594	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1415784007595	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1415784007596	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
1415784007597	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1415784007598	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1415784007599	active site
1415784007600	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1415784007601	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1415784007602	NAD(P) binding site [chemical binding]; other site
1415784007603	active site
1415784007604	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1415784007605	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1415784007606	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1415784007607	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1415784007608	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1415784007609	ABC transporter; Region: ABC_tran_2; pfam12848
1415784007610	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1415784007611	conserved hypothetical integral membrane protein; Region: TIGR03766
1415784007612	conserved hypothetical integral membrane protein; Region: TIGR03766
1415784007613	Predicted membrane protein [Function unknown]; Region: COG2246
1415784007614	GtrA-like protein; Region: GtrA; pfam04138
1415784007615	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1415784007616	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1415784007617	Ligand binding site; other site
1415784007618	Putative Catalytic site; other site
1415784007619	DXD motif; other site
1415784007620	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1415784007621	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1415784007622	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1415784007623	Protein export membrane protein; Region: SecD_SecF; cl14618
1415784007624	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
1415784007625	methionine sulfoxide reductase B; Provisional; Region: PRK00222
1415784007626	SelR domain; Region: SelR; pfam01641
1415784007627	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1415784007628	antiholin-like protein LrgB; Provisional; Region: PRK04288
1415784007629	murein hydrolase regulator LrgA; Provisional; Region: PRK04125
1415784007630	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1415784007631	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784007632	active site
1415784007633	phosphorylation site [posttranslational modification]
1415784007634	intermolecular recognition site; other site
1415784007635	dimerization interface [polypeptide binding]; other site
1415784007636	LytTr DNA-binding domain; Region: LytTR; pfam04397
1415784007637	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
1415784007638	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1415784007639	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1415784007640	Histidine kinase; Region: His_kinase; pfam06580
1415784007641	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784007642	ATP binding site [chemical binding]; other site
1415784007643	Mg2+ binding site [ion binding]; other site
1415784007644	G-X-G motif; other site
1415784007645	benzoate transport; Region: 2A0115; TIGR00895
1415784007646	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784007647	putative substrate translocation pore; other site
1415784007648	BCCT family transporter; Region: BCCT; pfam02028
1415784007649	Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575
1415784007650	active site
1415784007651	dimer interface [polypeptide binding]; other site
1415784007652	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1415784007653	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1415784007654	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1415784007655	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1415784007656	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1415784007657	NAD(P) binding site [chemical binding]; other site
1415784007658	active site
1415784007659	AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293
1415784007660	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1415784007661	UDP-glucose 4-epimerase; Region: PLN02240
1415784007662	NAD binding site [chemical binding]; other site
1415784007663	homodimer interface [polypeptide binding]; other site
1415784007664	active site
1415784007665	substrate binding site [chemical binding]; other site
1415784007666	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1415784007667	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
1415784007668	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
1415784007669	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1415784007670	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1415784007671	ATP binding site [chemical binding]; other site
1415784007672	Mg++ binding site [ion binding]; other site
1415784007673	motif III; other site
1415784007674	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1415784007675	nucleotide binding region [chemical binding]; other site
1415784007676	ATP-binding site [chemical binding]; other site
1415784007677	RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500
1415784007678	RNA binding site [nucleotide binding]; other site
1415784007679	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
1415784007680	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1415784007681	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
1415784007682	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1415784007683	active site
1415784007684	oligoendopeptidase F; Region: pepF; TIGR00181
1415784007685	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609
1415784007686	active site
1415784007687	Zn binding site [ion binding]; other site
1415784007688	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
1415784007689	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1415784007690	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
1415784007691	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
1415784007692	CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129
1415784007693	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1415784007694	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1415784007695	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1415784007696	protein binding site [polypeptide binding]; other site
1415784007697	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
1415784007698	YycH protein; Region: YycI; pfam09648
1415784007699	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863
1415784007700	YycH protein; Region: YycH; pfam07435
1415784007701	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
1415784007702	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1415784007703	dimerization interface [polypeptide binding]; other site
1415784007704	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1415784007705	putative active site [active]
1415784007706	heme pocket [chemical binding]; other site
1415784007707	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1415784007708	dimer interface [polypeptide binding]; other site
1415784007709	phosphorylation site [posttranslational modification]
1415784007710	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784007711	ATP binding site [chemical binding]; other site
1415784007712	Mg2+ binding site [ion binding]; other site
1415784007713	G-X-G motif; other site
1415784007714	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1415784007715	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784007716	active site
1415784007717	phosphorylation site [posttranslational modification]
1415784007718	intermolecular recognition site; other site
1415784007719	dimerization interface [polypeptide binding]; other site
1415784007720	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1415784007721	DNA binding site [nucleotide binding]
1415784007722	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1415784007723	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1415784007724	GDP-binding site [chemical binding]; other site
1415784007725	ACT binding site; other site
1415784007726	IMP binding site; other site
1415784007727	replicative DNA helicase; Provisional; Region: PRK05748
1415784007728	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1415784007729	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
1415784007730	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1415784007731	Walker A motif; other site
1415784007732	ATP binding site [chemical binding]; other site
1415784007733	Walker B motif; other site
1415784007734	DNA binding loops [nucleotide binding]
1415784007735	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1415784007736	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1415784007737	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1415784007738	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
1415784007739	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
1415784007740	DHH family; Region: DHH; pfam01368
1415784007741	DHHA1 domain; Region: DHHA1; pfam02272
1415784007742	Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991
1415784007743	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1415784007744	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1415784007745	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1415784007746	dimer interface [polypeptide binding]; other site
1415784007747	ssDNA binding site [nucleotide binding]; other site
1415784007748	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1415784007749	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1415784007750	GTP-binding protein YchF; Reviewed; Region: PRK09601
1415784007751	YchF GTPase; Region: YchF; cd01900
1415784007752	G1 box; other site
1415784007753	GTP/Mg2+ binding site [chemical binding]; other site
1415784007754	Switch I region; other site
1415784007755	G2 box; other site
1415784007756	Switch II region; other site
1415784007757	G3 box; other site
1415784007758	G4 box; other site
1415784007759	G5 box; other site
1415784007760	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1415784007761	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
1415784007762	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1415784007763	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1415784007764	putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841
1415784007765	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1415784007766	ParB-like nuclease domain; Region: ParB; smart00470
1415784007767	KorB domain; Region: KorB; pfam08535
1415784007768	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1415784007769	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1415784007770	P-loop; other site
1415784007771	Magnesium ion binding site [ion binding]; other site
1415784007772	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1415784007773	Magnesium ion binding site [ion binding]; other site
1415784007774	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
1415784007775	ParB-like nuclease domain; Region: ParBc; pfam02195
1415784007776	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1415784007777	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784007778	S-adenosylmethionine binding site [chemical binding]; other site
1415784007779	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1415784007780	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
1415784007781	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1415784007782	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1415784007783	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1415784007784	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1415784007785	G1 box; other site
1415784007786	GTP/Mg2+ binding site [chemical binding]; other site
1415784007787	Switch I region; other site
1415784007788	G2 box; other site
1415784007789	Switch II region; other site
1415784007790	G3 box; other site
1415784007791	G4 box; other site
1415784007792	G5 box; other site
1415784007793	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1415784007794	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
1415784007795	RxxxH motif; other site
1415784007796	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
1415784007797	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
1415784007798	G-X-X-G motif; other site
1415784007799	OxaA-like protein precursor; Validated; Region: PRK02944
1415784007800	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
1415784007801	ribonuclease P; Reviewed; Region: rnpA; PRK00499
1415784007802	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
1415784007803	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
1415784007804	DnaA N-terminal domain; Region: DnaA_N; pfam11638
1415784007805	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1415784007806	Walker A motif; other site
1415784007807	ATP binding site [chemical binding]; other site
1415784007808	Walker B motif; other site
1415784007809	arginine finger; other site
1415784007810	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1415784007811	DnaA box-binding interface [nucleotide binding]; other site
1415784007812	DNA polymerase III subunit beta; Validated; Region: PRK05643
1415784007813	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1415784007814	putative DNA binding surface [nucleotide binding]; other site
1415784007815	dimer interface [polypeptide binding]; other site
1415784007816	beta-clamp/clamp loader binding surface; other site
1415784007817	beta-clamp/translesion DNA polymerase binding surface; other site
1415784007818	S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988
1415784007819	recombination protein F; Reviewed; Region: recF; PRK00064
1415784007820	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
1415784007821	Walker A/P-loop; other site
1415784007822	ATP binding site [chemical binding]; other site
1415784007823	Q-loop/lid; other site
1415784007824	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1415784007825	ABC transporter signature motif; other site
1415784007826	Walker B; other site
1415784007827	D-loop; other site
1415784007828	H-loop/switch region; other site
1415784007829	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1415784007830	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784007831	Mg2+ binding site [ion binding]; other site
1415784007832	G-X-G motif; other site
1415784007833	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1415784007834	anchoring element; other site
1415784007835	dimer interface [polypeptide binding]; other site
1415784007836	ATP binding site [chemical binding]; other site
1415784007837	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1415784007838	active site
1415784007839	putative metal-binding site [ion binding]; other site
1415784007840	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1415784007841	DNA gyrase subunit A; Validated; Region: PRK05560
1415784007842	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1415784007843	CAP-like domain; other site
1415784007844	active site
1415784007845	primary dimer interface [polypeptide binding]; other site
1415784007846	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1415784007847	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1415784007848	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1415784007849	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1415784007850	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1415784007851	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1415784007852	YaaC-like Protein; Region: YaaC; pfam14175
1415784007853	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1415784007854	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1415784007855	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1415784007856	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1415784007857	active site
1415784007858	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1415784007859	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1415784007860	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
1415784007861	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
1415784007862	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
1415784007863	active site
1415784007864	multimer interface [polypeptide binding]; other site
1415784007865	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
1415784007866	predicted active site [active]
1415784007867	catalytic triad [active]
1415784007868	seryl-tRNA synthetase; Provisional; Region: PRK05431
1415784007869	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1415784007870	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1415784007871	dimer interface [polypeptide binding]; other site
1415784007872	active site
1415784007873	motif 1; other site
1415784007874	motif 2; other site
1415784007875	motif 3; other site
1415784007876	Domain of unknown function (DUF3797); Region: DUF3797; pfam12677
1415784007877	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
1415784007878	DNA binding residues [nucleotide binding]
1415784007879	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
1415784007880	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
1415784007881	Substrate-binding site [chemical binding]; other site
1415784007882	Substrate specificity [chemical binding]; other site
1415784007883	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
1415784007884	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
1415784007885	Substrate-binding site [chemical binding]; other site
1415784007886	Substrate specificity [chemical binding]; other site
1415784007887	Isochorismatase family; Region: Isochorismatase; pfam00857
1415784007888	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1415784007889	catalytic triad [active]
1415784007890	conserved cis-peptide bond; other site
1415784007891	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1415784007892	nucleoside/Zn binding site; other site
1415784007893	dimer interface [polypeptide binding]; other site
1415784007894	catalytic motif [active]
1415784007895	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
1415784007896	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1415784007897	Walker A motif; other site
1415784007898	ATP binding site [chemical binding]; other site
1415784007899	Walker B motif; other site
1415784007900	arginine finger; other site
1415784007901	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1415784007902	hypothetical protein; Validated; Region: PRK00153
1415784007903	recombination protein RecR; Reviewed; Region: recR; PRK00076
1415784007904	RecR protein; Region: RecR; pfam02132
1415784007905	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1415784007906	putative active site [active]
1415784007907	putative metal-binding site [ion binding]; other site
1415784007908	tetramer interface [polypeptide binding]; other site
1415784007909	Protein of unknown function (DUF2508); Region: DUF2508; pfam10704
1415784007910	pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862
1415784007911	Inhibitor of sigma-G Gin; Region: Gin; pfam10764
1415784007912	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
1415784007913	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
1415784007914	homodimer interface [polypeptide binding]; other site
1415784007915	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784007916	catalytic residue [active]
1415784007917	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1415784007918	thymidylate kinase; Validated; Region: tmk; PRK00698
1415784007919	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1415784007920	TMP-binding site; other site
1415784007921	ATP-binding site [chemical binding]; other site
1415784007922	DNA polymerase III subunit delta'; Validated; Region: PRK08058
1415784007923	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1415784007924	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
1415784007925	DNA replication intiation control protein YabA; Reviewed; Region: PRK13169
1415784007926	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
1415784007927	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784007928	S-adenosylmethionine binding site [chemical binding]; other site
1415784007929	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
1415784007930	putative active site [active]
1415784007931	GIY-YIG motif/motif A; other site
1415784007932	putative metal binding site [ion binding]; other site
1415784007933	Predicted methyltransferases [General function prediction only]; Region: COG0313
1415784007934	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1415784007935	putative SAM binding site [chemical binding]; other site
1415784007936	putative homodimer interface [polypeptide binding]; other site
1415784007937	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
1415784007938	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
1415784007939	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
1415784007940	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1415784007941	active site
1415784007942	HIGH motif; other site
1415784007943	KMSKS motif; other site
1415784007944	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1415784007945	tRNA binding surface [nucleotide binding]; other site
1415784007946	anticodon binding site; other site
1415784007947	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1415784007948	dimer interface [polypeptide binding]; other site
1415784007949	putative tRNA-binding site [nucleotide binding]; other site
1415784007950	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
1415784007951	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1415784007952	active site
1415784007953	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
1415784007954	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
1415784007955	putative active site [active]
1415784007956	putative metal binding site [ion binding]; other site
1415784007957	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
1415784007958	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1415784007959	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784007960	S-adenosylmethionine binding site [chemical binding]; other site
1415784007961	sporulation peptidase YabG; Region: spore_yabG; TIGR02855
1415784007962	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
1415784007963	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
1415784007964	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
1415784007965	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1415784007966	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1415784007967	pur operon repressor; Provisional; Region: PRK09213
1415784007968	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
1415784007969	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1415784007970	active site
1415784007971	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1415784007972	homotrimer interaction site [polypeptide binding]; other site
1415784007973	putative active site [active]
1415784007974	regulatory protein SpoVG; Reviewed; Region: PRK13259
1415784007975	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
1415784007976	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1415784007977	Substrate binding site; other site
1415784007978	Mg++ binding site; other site
1415784007979	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1415784007980	active site
1415784007981	substrate binding site [chemical binding]; other site
1415784007982	CoA binding site [chemical binding]; other site
1415784007983	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1415784007984	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1415784007985	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1415784007986	active site
1415784007987	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1415784007988	putative active site [active]
1415784007989	catalytic residue [active]
1415784007990	Protein of unknown function (DUF2757); Region: DUF2757; pfam10955
1415784007991	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1415784007992	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1415784007993	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1415784007994	ATP binding site [chemical binding]; other site
1415784007995	putative Mg++ binding site [ion binding]; other site
1415784007996	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1415784007997	nucleotide binding region [chemical binding]; other site
1415784007998	ATP-binding site [chemical binding]; other site
1415784007999	TRCF domain; Region: TRCF; pfam03461
1415784008000	stage V sporulation protein T; Region: spore_V_T; TIGR02851
1415784008001	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014
1415784008002	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1415784008003	Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956
1415784008004	N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723
1415784008005	putative SAM binding site [chemical binding]; other site
1415784008006	putative homodimer interface [polypeptide binding]; other site
1415784008007	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1415784008008	homodimer interface [polypeptide binding]; other site
1415784008009	metal binding site [ion binding]; metal-binding site
1415784008010	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
1415784008011	homodimer interface [polypeptide binding]; other site
1415784008012	active site
1415784008013	putative chemical substrate binding site [chemical binding]; other site
1415784008014	metal binding site [ion binding]; metal-binding site
1415784008015	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1415784008016	RNA binding surface [nucleotide binding]; other site
1415784008017	sporulation protein YabP; Region: spore_yabP; TIGR02892
1415784008018	spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893
1415784008019	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
1415784008020	Septum formation initiator; Region: DivIC; pfam04977
1415784008021	hypothetical protein; Provisional; Region: PRK08582
1415784008022	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1415784008023	RNA binding site [nucleotide binding]; other site
1415784008024	stage II sporulation protein E; Region: spore_II_E; TIGR02865
1415784008025	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
1415784008026	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1415784008027	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1415784008028	Ligand Binding Site [chemical binding]; other site
1415784008029	TilS substrate C-terminal domain; Region: TilS_C; smart00977
1415784008030	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1415784008031	active site
1415784008032	FtsH Extracellular; Region: FtsH_ext; pfam06480
1415784008033	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1415784008034	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1415784008035	Walker A motif; other site
1415784008036	ATP binding site [chemical binding]; other site
1415784008037	Walker B motif; other site
1415784008038	arginine finger; other site
1415784008039	Peptidase family M41; Region: Peptidase_M41; pfam01434
1415784008040	pantothenate kinase; Reviewed; Region: PRK13318
1415784008041	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
1415784008042	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
1415784008043	dimerization interface [polypeptide binding]; other site
1415784008044	domain crossover interface; other site
1415784008045	redox-dependent activation switch; other site
1415784008046	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1415784008047	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1415784008048	dimer interface [polypeptide binding]; other site
1415784008049	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784008050	catalytic residue [active]
1415784008051	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
1415784008052	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1415784008053	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1415784008054	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
1415784008055	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1415784008056	glutamine binding [chemical binding]; other site
1415784008057	catalytic triad [active]
1415784008058	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1415784008059	4-amino-4-deoxychorismate lyase; Provisional; Region: PRK07650
1415784008060	homodimer interface [polypeptide binding]; other site
1415784008061	substrate-cofactor binding pocket; other site
1415784008062	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784008063	catalytic residue [active]
1415784008064	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1415784008065	dihydropteroate synthase; Region: DHPS; TIGR01496
1415784008066	substrate binding pocket [chemical binding]; other site
1415784008067	dimer interface [polypeptide binding]; other site
1415784008068	inhibitor binding site; inhibition site
1415784008069	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1415784008070	homooctamer interface [polypeptide binding]; other site
1415784008071	active site
1415784008072	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1415784008073	catalytic center binding site [active]
1415784008074	ATP binding site [chemical binding]; other site
1415784008075	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1415784008076	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1415784008077	non-specific DNA binding site [nucleotide binding]; other site
1415784008078	salt bridge; other site
1415784008079	sequence-specific DNA binding site [nucleotide binding]; other site
1415784008080	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
1415784008081	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1415784008082	FMN binding site [chemical binding]; other site
1415784008083	active site
1415784008084	catalytic residues [active]
1415784008085	substrate binding site [chemical binding]; other site
1415784008086	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1415784008087	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1415784008088	dimer interface [polypeptide binding]; other site
1415784008089	putative anticodon binding site; other site
1415784008090	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1415784008091	motif 1; other site
1415784008092	active site
1415784008093	motif 2; other site
1415784008094	motif 3; other site
1415784008095	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
1415784008096	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
1415784008097	UvrB/uvrC motif; Region: UVR; pfam02151
1415784008098	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
1415784008099	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
1415784008100	ADP binding site [chemical binding]; other site
1415784008101	phosphagen binding site; other site
1415784008102	substrate specificity loop; other site
1415784008103	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1415784008104	Clp amino terminal domain; Region: Clp_N; pfam02861
1415784008105	Clp amino terminal domain; Region: Clp_N; pfam02861
1415784008106	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1415784008107	Walker A motif; other site
1415784008108	ATP binding site [chemical binding]; other site
1415784008109	Walker B motif; other site
1415784008110	arginine finger; other site
1415784008111	UvrB/uvrC motif; Region: UVR; pfam02151
1415784008112	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1415784008113	Walker A motif; other site
1415784008114	ATP binding site [chemical binding]; other site
1415784008115	Walker B motif; other site
1415784008116	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1415784008117	DNA repair protein RadA; Provisional; Region: PRK11823
1415784008118	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
1415784008119	Walker A motif/ATP binding site; other site
1415784008120	ATP binding site [chemical binding]; other site
1415784008121	Walker B motif; other site
1415784008122	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1415784008123	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
1415784008124	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1415784008125	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
1415784008126	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
1415784008127	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
1415784008128	putative active site [active]
1415784008129	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1415784008130	substrate binding site; other site
1415784008131	dimer interface; other site
1415784008132	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1415784008133	homotrimer interaction site [polypeptide binding]; other site
1415784008134	zinc binding site [ion binding]; other site
1415784008135	CDP-binding sites; other site
1415784008136	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1415784008137	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1415784008138	HIGH motif; other site
1415784008139	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1415784008140	active site
1415784008141	KMSKS motif; other site
1415784008142	serine O-acetyltransferase; Region: cysE; TIGR01172
1415784008143	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
1415784008144	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1415784008145	trimer interface [polypeptide binding]; other site
1415784008146	active site
1415784008147	substrate binding site [chemical binding]; other site
1415784008148	CoA binding site [chemical binding]; other site
1415784008149	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1415784008150	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1415784008151	active site
1415784008152	HIGH motif; other site
1415784008153	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1415784008154	KMSKS motif; other site
1415784008155	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1415784008156	tRNA binding surface [nucleotide binding]; other site
1415784008157	anticodon binding site; other site
1415784008158	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
1415784008159	active site
1415784008160	metal binding site [ion binding]; metal-binding site
1415784008161	dimerization interface [polypeptide binding]; other site
1415784008162	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
1415784008163	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1415784008164	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1415784008165	YacP-like NYN domain; Region: NYN_YacP; pfam05991
1415784008166	RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859
1415784008167	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1415784008168	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1415784008169	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
1415784008170	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
1415784008171	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1415784008172	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1415784008173	putative homodimer interface [polypeptide binding]; other site
1415784008174	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1415784008175	heterodimer interface [polypeptide binding]; other site
1415784008176	homodimer interface [polypeptide binding]; other site
1415784008177	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1415784008178	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1415784008179	23S rRNA interface [nucleotide binding]; other site
1415784008180	L7/L12 interface [polypeptide binding]; other site
1415784008181	putative thiostrepton binding site; other site
1415784008182	L25 interface [polypeptide binding]; other site
1415784008183	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1415784008184	mRNA/rRNA interface [nucleotide binding]; other site
1415784008185	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1415784008186	23S rRNA interface [nucleotide binding]; other site
1415784008187	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1415784008188	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1415784008189	core dimer interface [polypeptide binding]; other site
1415784008190	peripheral dimer interface [polypeptide binding]; other site
1415784008191	L10 interface [polypeptide binding]; other site
1415784008192	L11 interface [polypeptide binding]; other site
1415784008193	putative EF-Tu interaction site [polypeptide binding]; other site
1415784008194	putative EF-G interaction site [polypeptide binding]; other site
1415784008195	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
1415784008196	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784008197	S-adenosylmethionine binding site [chemical binding]; other site
1415784008198	DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085
1415784008199	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1415784008200	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1415784008201	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1415784008202	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
1415784008203	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1415784008204	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1415784008205	RPB10 interaction site [polypeptide binding]; other site
1415784008206	RPB1 interaction site [polypeptide binding]; other site
1415784008207	RPB11 interaction site [polypeptide binding]; other site
1415784008208	RPB3 interaction site [polypeptide binding]; other site
1415784008209	RPB12 interaction site [polypeptide binding]; other site
1415784008210	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
1415784008211	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1415784008212	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1415784008213	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1415784008214	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1415784008215	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1415784008216	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
1415784008217	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1415784008218	G-loop; other site
1415784008219	DNA binding site [nucleotide binding]
1415784008220	hypothetical protein; Provisional; Region: PRK06683
1415784008221	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1415784008222	S17 interaction site [polypeptide binding]; other site
1415784008223	S8 interaction site; other site
1415784008224	16S rRNA interaction site [nucleotide binding]; other site
1415784008225	streptomycin interaction site [chemical binding]; other site
1415784008226	23S rRNA interaction site [nucleotide binding]; other site
1415784008227	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1415784008228	30S ribosomal protein S7; Validated; Region: PRK05302
1415784008229	elongation factor G; Reviewed; Region: PRK00007
1415784008230	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1415784008231	G1 box; other site
1415784008232	putative GEF interaction site [polypeptide binding]; other site
1415784008233	GTP/Mg2+ binding site [chemical binding]; other site
1415784008234	Switch I region; other site
1415784008235	G2 box; other site
1415784008236	G3 box; other site
1415784008237	Switch II region; other site
1415784008238	G4 box; other site
1415784008239	G5 box; other site
1415784008240	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1415784008241	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1415784008242	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1415784008243	elongation factor Tu; Reviewed; Region: PRK00049
1415784008244	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1415784008245	G1 box; other site
1415784008246	GEF interaction site [polypeptide binding]; other site
1415784008247	GTP/Mg2+ binding site [chemical binding]; other site
1415784008248	Switch I region; other site
1415784008249	G2 box; other site
1415784008250	G3 box; other site
1415784008251	Switch II region; other site
1415784008252	G4 box; other site
1415784008253	G5 box; other site
1415784008254	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1415784008255	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1415784008256	Antibiotic Binding Site [chemical binding]; other site
1415784008257	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1415784008258	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1415784008259	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1415784008260	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1415784008261	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1415784008262	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1415784008263	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1415784008264	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1415784008265	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1415784008266	putative translocon binding site; other site
1415784008267	protein-rRNA interface [nucleotide binding]; other site
1415784008268	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1415784008269	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1415784008270	G-X-X-G motif; other site
1415784008271	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1415784008272	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1415784008273	23S rRNA interface [nucleotide binding]; other site
1415784008274	5S rRNA interface [nucleotide binding]; other site
1415784008275	putative antibiotic binding site [chemical binding]; other site
1415784008276	L25 interface [polypeptide binding]; other site
1415784008277	L27 interface [polypeptide binding]; other site
1415784008278	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1415784008279	23S rRNA interface [nucleotide binding]; other site
1415784008280	putative translocon interaction site; other site
1415784008281	signal recognition particle (SRP54) interaction site; other site
1415784008282	L23 interface [polypeptide binding]; other site
1415784008283	trigger factor interaction site; other site
1415784008284	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1415784008285	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1415784008286	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1415784008287	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1415784008288	RNA binding site [nucleotide binding]; other site
1415784008289	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1415784008290	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1415784008291	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1415784008292	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
1415784008293	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1415784008294	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1415784008295	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1415784008296	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1415784008297	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1415784008298	5S rRNA interface [nucleotide binding]; other site
1415784008299	L27 interface [polypeptide binding]; other site
1415784008300	23S rRNA interface [nucleotide binding]; other site
1415784008301	L5 interface [polypeptide binding]; other site
1415784008302	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1415784008303	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1415784008304	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1415784008305	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1415784008306	23S rRNA binding site [nucleotide binding]; other site
1415784008307	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1415784008308	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907
1415784008309	SecY translocase; Region: SecY; pfam00344
1415784008310	adenylate kinase; Reviewed; Region: adk; PRK00279
1415784008311	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1415784008312	AMP-binding site [chemical binding]; other site
1415784008313	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1415784008314	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1415784008315	active site
1415784008316	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1415784008317	rRNA binding site [nucleotide binding]; other site
1415784008318	predicted 30S ribosome binding site; other site
1415784008319	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
1415784008320	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1415784008321	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1415784008322	30S ribosomal protein S11; Validated; Region: PRK05309
1415784008323	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1415784008324	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1415784008325	alphaNTD - beta interaction site [polypeptide binding]; other site
1415784008326	alphaNTD homodimer interface [polypeptide binding]; other site
1415784008327	alphaNTD - beta' interaction site [polypeptide binding]; other site
1415784008328	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1415784008329	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1415784008330	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635
1415784008331	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1415784008332	Walker A/P-loop; other site
1415784008333	ATP binding site [chemical binding]; other site
1415784008334	Q-loop/lid; other site
1415784008335	ABC transporter signature motif; other site
1415784008336	Walker B; other site
1415784008337	D-loop; other site
1415784008338	H-loop/switch region; other site
1415784008339	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634
1415784008340	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1415784008341	Walker A/P-loop; other site
1415784008342	ATP binding site [chemical binding]; other site
1415784008343	Q-loop/lid; other site
1415784008344	ABC transporter signature motif; other site
1415784008345	Walker B; other site
1415784008346	D-loop; other site
1415784008347	H-loop/switch region; other site
1415784008348	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1415784008349	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1415784008350	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1415784008351	dimerization interface 3.5A [polypeptide binding]; other site
1415784008352	active site
1415784008353	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1415784008354	23S rRNA interface [nucleotide binding]; other site
1415784008355	L3 interface [polypeptide binding]; other site
1415784008356	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1415784008357	Protein of unknown function (DUF2521); Region: DUF2521; pfam10730
1415784008358	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1415784008359	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1415784008360	active site
1415784008361	Domain of unknown function DUF59; Region: DUF59; cl00941
1415784008362	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1415784008363	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
1415784008364	KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089
1415784008365	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1415784008366	Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949
1415784008367	NodB motif; other site
1415784008368	putative active site [active]
1415784008369	putative catalytic site [active]
1415784008370	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
1415784008371	Arginase family; Region: Arginase; cd09989
1415784008372	agmatinase; Region: agmatinase; TIGR01230
1415784008373	active site
1415784008374	Mn binding site [ion binding]; other site
1415784008375	oligomer interface [polypeptide binding]; other site
1415784008376	Uncharacterized conserved protein [Function unknown]; Region: COG1624
1415784008377	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1415784008378	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
1415784008379	YbbR-like protein; Region: YbbR; pfam07949
1415784008380	YbbR-like protein; Region: YbbR; pfam07949
1415784008381	YbbR-like protein; Region: YbbR; pfam07949
1415784008382	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
1415784008383	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1415784008384	active site
1415784008385	substrate binding site [chemical binding]; other site
1415784008386	metal binding site [ion binding]; metal-binding site
1415784008387	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1415784008388	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1415784008389	glutaminase active site [active]
1415784008390	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1415784008391	dimer interface [polypeptide binding]; other site
1415784008392	active site
1415784008393	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1415784008394	dimer interface [polypeptide binding]; other site
1415784008395	active site
1415784008396	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
1415784008397	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1415784008398	Protein of unknown function (DUF4256); Region: DUF4256; pfam14066
1415784008399	Predicted membrane protein [Function unknown]; Region: COG2259
1415784008400	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859
1415784008401	classical (c) SDRs; Region: SDR_c; cd05233
1415784008402	NAD(P) binding site [chemical binding]; other site
1415784008403	active site
1415784008404	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784008405	ABC-ATPase subunit interface; other site
1415784008406	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
1415784008407	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1415784008408	Walker A/P-loop; other site
1415784008409	ATP binding site [chemical binding]; other site
1415784008410	Q-loop/lid; other site
1415784008411	ABC transporter signature motif; other site
1415784008412	Walker B; other site
1415784008413	D-loop; other site
1415784008414	H-loop/switch region; other site
1415784008415	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1415784008416	NIL domain; Region: NIL; pfam09383
1415784008417	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1415784008418	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1415784008419	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1415784008420	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267
1415784008421	putative NAD(P) binding site [chemical binding]; other site
1415784008422	FAD binding domain; Region: FAD_binding_4; pfam01565
1415784008423	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1415784008424	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
1415784008425	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1415784008426	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784008427	putative substrate translocation pore; other site
1415784008428	Domain of unknown function (DUF3981); Region: DUF3981; pfam13139
1415784008429	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
1415784008430	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784008431	putative substrate translocation pore; other site
1415784008432	Protein of unknown function (DUF3887); Region: DUF3887; pfam13026
1415784008433	Protein of unknown function (DUF3951); Region: DUF3951; pfam13131
1415784008434	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1415784008435	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784008436	dimer interface [polypeptide binding]; other site
1415784008437	conserved gate region; other site
1415784008438	putative PBP binding loops; other site
1415784008439	ABC-ATPase subunit interface; other site
1415784008440	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1415784008441	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784008442	dimer interface [polypeptide binding]; other site
1415784008443	conserved gate region; other site
1415784008444	putative PBP binding loops; other site
1415784008445	ABC-ATPase subunit interface; other site
1415784008446	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1415784008447	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1415784008448	Walker A/P-loop; other site
1415784008449	ATP binding site [chemical binding]; other site
1415784008450	Q-loop/lid; other site
1415784008451	ABC transporter signature motif; other site
1415784008452	Walker B; other site
1415784008453	D-loop; other site
1415784008454	H-loop/switch region; other site
1415784008455	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1415784008456	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1415784008457	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1415784008458	Walker A/P-loop; other site
1415784008459	ATP binding site [chemical binding]; other site
1415784008460	Q-loop/lid; other site
1415784008461	ABC transporter signature motif; other site
1415784008462	Walker B; other site
1415784008463	D-loop; other site
1415784008464	H-loop/switch region; other site
1415784008465	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1415784008466	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1415784008467	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1415784008468	peptide binding site [polypeptide binding]; other site
1415784008469	YusW-like protein; Region: YusW; pfam14039
1415784008470	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1415784008471	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1415784008472	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1415784008473	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1415784008474	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1415784008475	peptide binding site [polypeptide binding]; other site
1415784008476	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1415784008477	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1415784008478	peptide binding site [polypeptide binding]; other site
1415784008479	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1415784008480	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1415784008481	active site
1415784008482	catalytic tetrad [active]
1415784008483	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07634
1415784008484	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
1415784008485	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
1415784008486	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
1415784008487	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1415784008488	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784008489	dimer interface [polypeptide binding]; other site
1415784008490	conserved gate region; other site
1415784008491	putative PBP binding loops; other site
1415784008492	ABC-ATPase subunit interface; other site
1415784008493	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
1415784008494	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1415784008495	dimerization interface [polypeptide binding]; other site
1415784008496	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1415784008497	membrane-bound complex binding site; other site
1415784008498	hinge residues; other site
1415784008499	DNA binding domain, excisionase family; Region: excise; TIGR01764
1415784008500	PBP superfamily domain; Region: PBP_like; pfam12727
1415784008501	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1415784008502	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1415784008503	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
1415784008504	putative dimerization interface [polypeptide binding]; other site
1415784008505	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1415784008506	EamA-like transporter family; Region: EamA; pfam00892
1415784008507	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1415784008508	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1415784008509	putative acyl-acceptor binding pocket; other site
1415784008510	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1415784008511	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1415784008512	DNA binding site [nucleotide binding]
1415784008513	domain linker motif; other site
1415784008514	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
1415784008515	putative ligand binding site [chemical binding]; other site
1415784008516	putative dimerization interface [polypeptide binding]; other site
1415784008517	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1415784008518	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1415784008519	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1415784008520	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1415784008521	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
1415784008522	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1415784008523	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
1415784008524	active site
1415784008525	Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923
1415784008526	Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096
1415784008527	NodB motif; other site
1415784008528	putative active site [active]
1415784008529	putative catalytic site [active]
1415784008530	putative Zn binding site [ion binding]; other site
1415784008531	C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have...; Region: LYZ1; cl17441
1415784008532	lysozyme catalytic site [active]
1415784008533	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
1415784008534	nucleotide binding site/active site [active]
1415784008535	HIT family signature motif; other site
1415784008536	catalytic residue [active]
1415784008537	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1415784008538	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1415784008539	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1415784008540	ABC transporter; Region: ABC_tran_2; pfam12848
1415784008541	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1415784008542	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1415784008543	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
1415784008544	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1415784008545	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784008546	dimer interface [polypeptide binding]; other site
1415784008547	conserved gate region; other site
1415784008548	putative PBP binding loops; other site
1415784008549	ABC-ATPase subunit interface; other site
1415784008550	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1415784008551	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1415784008552	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784008553	dimer interface [polypeptide binding]; other site
1415784008554	conserved gate region; other site
1415784008555	putative PBP binding loops; other site
1415784008556	ABC-ATPase subunit interface; other site
1415784008557	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1415784008558	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1415784008559	Walker A/P-loop; other site
1415784008560	ATP binding site [chemical binding]; other site
1415784008561	Q-loop/lid; other site
1415784008562	ABC transporter signature motif; other site
1415784008563	Walker B; other site
1415784008564	D-loop; other site
1415784008565	H-loop/switch region; other site
1415784008566	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1415784008567	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
1415784008568	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1415784008569	Walker A/P-loop; other site
1415784008570	ATP binding site [chemical binding]; other site
1415784008571	Q-loop/lid; other site
1415784008572	ABC transporter signature motif; other site
1415784008573	Walker B; other site
1415784008574	D-loop; other site
1415784008575	H-loop/switch region; other site
1415784008576	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1415784008577	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1415784008578	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1415784008579	active site
1415784008580	motif I; other site
1415784008581	motif II; other site
1415784008582	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1415784008583	motif II; other site
1415784008584	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1415784008585	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
1415784008586	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
1415784008587	dimer interface [polypeptide binding]; other site
1415784008588	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
1415784008589	active site
1415784008590	Fe binding site [ion binding]; other site
1415784008591	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1415784008592	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1415784008593	homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
1415784008594	amino acid transporter; Region: 2A0306; TIGR00909
1415784008595	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1415784008596	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784008597	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1415784008598	putative substrate translocation pore; other site
1415784008599	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1415784008600	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1415784008601	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
1415784008602	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
1415784008603	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1415784008604	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1415784008605	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1415784008606	helicase 45; Provisional; Region: PTZ00424
1415784008607	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1415784008608	ATP binding site [chemical binding]; other site
1415784008609	Mg++ binding site [ion binding]; other site
1415784008610	motif III; other site
1415784008611	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1415784008612	nucleotide binding region [chemical binding]; other site
1415784008613	ATP-binding site [chemical binding]; other site
1415784008614	putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308
1415784008615	Rhomboid family; Region: Rhomboid; pfam01694
1415784008616	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1415784008617	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
1415784008618	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1415784008619	alanine racemase; Reviewed; Region: alr; PRK00053
1415784008620	active site
1415784008621	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1415784008622	dimer interface [polypeptide binding]; other site
1415784008623	substrate binding site [chemical binding]; other site
1415784008624	catalytic residues [active]
1415784008625	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
1415784008626	PemK-like protein; Region: PemK; pfam02452
1415784008627	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1415784008628	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1415784008629	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1415784008630	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
1415784008631	RNA binding site [nucleotide binding]; other site
1415784008632	hypothetical protein; Provisional; Region: PRK04351
1415784008633	SprT homologues; Region: SprT; cl01182
1415784008634	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
1415784008635	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1415784008636	Glycoprotease family; Region: Peptidase_M22; pfam00814
1415784008637	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1415784008638	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784008639	Coenzyme A binding pocket [chemical binding]; other site
1415784008640	UGMP family protein; Validated; Region: PRK09604
1415784008641	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1415784008642	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1415784008643	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1415784008644	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1415784008645	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1415784008646	ABC transporter; Region: ABC_tran_2; pfam12848
1415784008647	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1415784008648	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
1415784008649	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
1415784008650	CoA binding domain; Region: CoA_binding; pfam02629
1415784008651	Domain of unknown function (DUF4305); Region: DUF4305; pfam14146
1415784008652	CAAX protease self-immunity; Region: Abi; pfam02517
1415784008653	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1415784008654	oligomerisation interface [polypeptide binding]; other site
1415784008655	mobile loop; other site
1415784008656	roof hairpin; other site
1415784008657	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1415784008658	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1415784008659	ring oligomerisation interface [polypeptide binding]; other site
1415784008660	ATP/Mg binding site [chemical binding]; other site
1415784008661	stacking interactions; other site
1415784008662	hinge regions; other site
1415784008663	conserved hypothetical integral membrane protein; Region: TIGR03766
1415784008664	GMP synthase; Reviewed; Region: guaA; PRK00074
1415784008665	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1415784008666	AMP/PPi binding site [chemical binding]; other site
1415784008667	candidate oxyanion hole; other site
1415784008668	catalytic triad [active]
1415784008669	potential glutamine specificity residues [chemical binding]; other site
1415784008670	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1415784008671	ATP Binding subdomain [chemical binding]; other site
1415784008672	Ligand Binding sites [chemical binding]; other site
1415784008673	Dimerization subdomain; other site
1415784008674	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1415784008675	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1415784008676	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784008677	active site
1415784008678	phosphorylation site [posttranslational modification]
1415784008679	intermolecular recognition site; other site
1415784008680	dimerization interface [polypeptide binding]; other site
1415784008681	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1415784008682	DNA binding site [nucleotide binding]
1415784008683	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1415784008684	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1415784008685	dimerization interface [polypeptide binding]; other site
1415784008686	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1415784008687	dimer interface [polypeptide binding]; other site
1415784008688	phosphorylation site [posttranslational modification]
1415784008689	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784008690	ATP binding site [chemical binding]; other site
1415784008691	Mg2+ binding site [ion binding]; other site
1415784008692	G-X-G motif; other site
1415784008693	Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579
1415784008694	putative ligand binding site [chemical binding]; other site
1415784008695	putative catalytic site [active]
1415784008696	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1415784008697	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784008698	S-adenosylmethionine binding site [chemical binding]; other site
1415784008699	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784008700	S-adenosylmethionine binding site [chemical binding]; other site
1415784008701	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
1415784008702	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1415784008703	UDP-glucose 4-epimerase (G4E), subgroup 5, extended (e) SDRs; Region: UDP_G4E_5_SDR_e; cd05264
1415784008704	putative NAD(P) binding site [chemical binding]; other site
1415784008705	active site
1415784008706	putative substrate binding site [chemical binding]; other site
1415784008707	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1415784008708	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784008709	S-adenosylmethionine binding site [chemical binding]; other site
1415784008710	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1415784008711	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1415784008712	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1415784008713	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
1415784008714	active site
1415784008715	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1415784008716	EamA-like transporter family; Region: EamA; pfam00892
1415784008717	EamA-like transporter family; Region: EamA; pfam00892
1415784008718	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
1415784008719	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
1415784008720	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1415784008721	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1415784008722	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1415784008723	ABC transporter; Region: ABC_tran; pfam00005
1415784008724	Q-loop/lid; other site
1415784008725	ABC transporter signature motif; other site
1415784008726	Walker B; other site
1415784008727	D-loop; other site
1415784008728	H-loop/switch region; other site
1415784008729	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1415784008730	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1415784008731	dimer interface [polypeptide binding]; other site
1415784008732	phosphorylation site [posttranslational modification]
1415784008733	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784008734	ATP binding site [chemical binding]; other site
1415784008735	Mg2+ binding site [ion binding]; other site
1415784008736	G-X-G motif; other site
1415784008737	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1415784008738	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784008739	active site
1415784008740	phosphorylation site [posttranslational modification]
1415784008741	intermolecular recognition site; other site
1415784008742	dimerization interface [polypeptide binding]; other site
1415784008743	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1415784008744	DNA binding site [nucleotide binding]
1415784008745	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
1415784008746	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1415784008747	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1415784008748	NAD binding site [chemical binding]; other site
1415784008749	ATP-grasp domain; Region: ATP-grasp; pfam02222
1415784008750	adenylosuccinate lyase; Provisional; Region: PRK07492
1415784008751	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
1415784008752	tetramer interface [polypeptide binding]; other site
1415784008753	active site
1415784008754	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
1415784008755	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
1415784008756	ATP binding site [chemical binding]; other site
1415784008757	active site
1415784008758	substrate binding site [chemical binding]; other site
1415784008759	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
1415784008760	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
1415784008761	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1415784008762	putative active site [active]
1415784008763	catalytic triad [active]
1415784008764	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
1415784008765	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1415784008766	dimerization interface [polypeptide binding]; other site
1415784008767	ATP binding site [chemical binding]; other site
1415784008768	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1415784008769	dimerization interface [polypeptide binding]; other site
1415784008770	ATP binding site [chemical binding]; other site
1415784008771	amidophosphoribosyltransferase; Provisional; Region: PRK06781
1415784008772	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1415784008773	active site
1415784008774	tetramer interface [polypeptide binding]; other site
1415784008775	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1415784008776	active site
1415784008777	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1415784008778	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1415784008779	dimerization interface [polypeptide binding]; other site
1415784008780	putative ATP binding site [chemical binding]; other site
1415784008781	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1415784008782	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1415784008783	active site
1415784008784	substrate binding site [chemical binding]; other site
1415784008785	cosubstrate binding site; other site
1415784008786	catalytic site [active]
1415784008787	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1415784008788	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1415784008789	purine monophosphate binding site [chemical binding]; other site
1415784008790	dimer interface [polypeptide binding]; other site
1415784008791	putative catalytic residues [active]
1415784008792	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1415784008793	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1415784008794	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1415784008795	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1415784008796	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1415784008797	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1415784008798	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
1415784008799	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1415784008800	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
1415784008801	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
1415784008802	PcrB family; Region: PcrB; pfam01884
1415784008803	PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812
1415784008804	substrate binding site [chemical binding]; other site
1415784008805	putative active site [active]
1415784008806	dimer interface [polypeptide binding]; other site
1415784008807	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1415784008808	Part of AAA domain; Region: AAA_19; pfam13245
1415784008809	Family description; Region: UvrD_C_2; pfam13538
1415784008810	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1415784008811	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1415784008812	nucleotide binding pocket [chemical binding]; other site
1415784008813	K-X-D-G motif; other site
1415784008814	catalytic site [active]
1415784008815	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1415784008816	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1415784008817	Dimer interface [polypeptide binding]; other site
1415784008818	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
1415784008819	putative dimer interface [polypeptide binding]; other site
1415784008820	CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537
1415784008821	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
1415784008822	putative dimer interface [polypeptide binding]; other site
1415784008823	hypothetical protein; Provisional; Region: PRK10621
1415784008824	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1415784008825	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
1415784008826	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
1415784008827	Glutamate binding site [chemical binding]; other site
1415784008828	homodimer interface [polypeptide binding]; other site
1415784008829	NAD binding site [chemical binding]; other site
1415784008830	catalytic residues [active]
1415784008831	Isochorismatase family; Region: Isochorismatase; pfam00857
1415784008832	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
1415784008833	catalytic triad [active]
1415784008834	conserved cis-peptide bond; other site
1415784008835	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
1415784008836	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1415784008837	Walker A/P-loop; other site
1415784008838	ATP binding site [chemical binding]; other site
1415784008839	Q-loop/lid; other site
1415784008840	ABC transporter signature motif; other site
1415784008841	Walker B; other site
1415784008842	D-loop; other site
1415784008843	H-loop/switch region; other site
1415784008844	NIL domain; Region: NIL; pfam09383
1415784008845	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784008846	dimer interface [polypeptide binding]; other site
1415784008847	conserved gate region; other site
1415784008848	ABC-ATPase subunit interface; other site
1415784008849	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1415784008850	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1415784008851	Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787
1415784008852	Protein of unknown function (DUF3926); Region: DUF3926; pfam13080
1415784008853	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
1415784008854	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1415784008855	P loop; other site
1415784008856	Nucleotide binding site [chemical binding]; other site
1415784008857	DTAP/Switch II; other site
1415784008858	Switch I; other site
1415784008859	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1415784008860	putative dimer interface [polypeptide binding]; other site
1415784008861	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1415784008862	MarR family; Region: MarR; pfam01047
1415784008863	MarR family; Region: MarR_2; cl17246
1415784008864	yiaA/B two helix domain; Region: YiaAB; pfam05360
1415784008865	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1415784008866	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1415784008867	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1415784008868	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1415784008869	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1415784008870	GatB domain; Region: GatB_Yqey; pfam02637
1415784008871	putative lipid kinase; Reviewed; Region: PRK13337
1415784008872	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1415784008873	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1415784008874	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1415784008875	motif II; other site
1415784008876	4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918
1415784008877	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1415784008878	inhibitor-cofactor binding pocket; inhibition site
1415784008879	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784008880	catalytic residue [active]
1415784008881	PAS domain; Region: PAS_9; pfam13426
1415784008882	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1415784008883	putative active site [active]
1415784008884	heme pocket [chemical binding]; other site
1415784008885	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1415784008886	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1415784008887	Walker A motif; other site
1415784008888	ATP binding site [chemical binding]; other site
1415784008889	Walker B motif; other site
1415784008890	arginine finger; other site
1415784008891	succinic semialdehyde dehydrogenase; Region: PLN02278
1415784008892	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1415784008893	tetramerization interface [polypeptide binding]; other site
1415784008894	NAD(P) binding site [chemical binding]; other site
1415784008895	catalytic residues [active]
1415784008896	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1415784008897	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
1415784008898	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
1415784008899	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
1415784008900	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1415784008901	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
1415784008902	putative active site [active]
1415784008903	putative metal binding site [ion binding]; other site
1415784008904	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1415784008905	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
1415784008906	putative active site [active]
1415784008907	putative metal binding site [ion binding]; other site
1415784008908	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1415784008909	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1415784008910	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1415784008911	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
1415784008912	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
1415784008913	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784008914	S-adenosylmethionine binding site [chemical binding]; other site
1415784008915	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
1415784008916	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1415784008917	FMN binding site [chemical binding]; other site
1415784008918	active site
1415784008919	catalytic residues [active]
1415784008920	substrate binding site [chemical binding]; other site
1415784008921	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1415784008922	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1415784008923	GAF domain; Region: GAF_3; pfam13492
1415784008924	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1415784008925	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1415784008926	dimer interface [polypeptide binding]; other site
1415784008927	phosphorylation site [posttranslational modification]
1415784008928	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784008929	ATP binding site [chemical binding]; other site
1415784008930	Mg2+ binding site [ion binding]; other site
1415784008931	G-X-G motif; other site
1415784008932	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
1415784008933	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
1415784008934	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
1415784008935	Protein of unknown function DUF45; Region: DUF45; pfam01863
1415784008936	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1415784008937	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
1415784008938	active site
1415784008939	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
1415784008940	C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322
1415784008941	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1415784008942	M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018
1415784008943	metal binding site [ion binding]; metal-binding site
1415784008944	putative dimer interface [polypeptide binding]; other site
1415784008945	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784008946	S-adenosylmethionine binding site [chemical binding]; other site
1415784008947	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
1415784008948	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
1415784008949	catalytic residue [active]
1415784008950	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
1415784008951	catalytic residues [active]
1415784008952	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1415784008953	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1415784008954	peroxiredoxin; Region: AhpC; TIGR03137
1415784008955	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1415784008956	dimer interface [polypeptide binding]; other site
1415784008957	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1415784008958	catalytic triad [active]
1415784008959	peroxidatic and resolving cysteines [active]
1415784008960	5-methylribose kinase; Reviewed; Region: PRK12396
1415784008961	Phosphotransferase enzyme family; Region: APH; pfam01636
1415784008962	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
1415784008963	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
1415784008964	L-fuculose phosphate aldolase; Provisional; Region: PRK06833
1415784008965	intersubunit interface [polypeptide binding]; other site
1415784008966	active site
1415784008967	Zn2+ binding site [ion binding]; other site
1415784008968	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1415784008969	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1415784008970	ABC-ATPase subunit  interface; other site
1415784008971	dimer interface [polypeptide binding]; other site
1415784008972	putative PBP binding regions; other site
1415784008973	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1415784008974	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1415784008975	ABC-ATPase subunit  interface; other site
1415784008976	dimer interface [polypeptide binding]; other site
1415784008977	putative PBP binding regions; other site
1415784008978	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1415784008979	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
1415784008980	putative ligand binding residues [chemical binding]; other site
1415784008981	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1415784008982	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1415784008983	YqaJ-like viral recombinase domain; Region: YqaJ; cl09232
1415784008984	DNA binding domain, excisionase family; Region: excise; TIGR01764
1415784008985	Sm and related proteins; Region: Sm_like; cl00259
1415784008986	heptamer interface [polypeptide binding]; other site
1415784008987	Sm1 motif; other site
1415784008988	hexamer interface [polypeptide binding]; other site
1415784008989	RNA binding site [nucleotide binding]; other site
1415784008990	Sm2 motif; other site
1415784008991	Sm and related proteins; Region: Sm_like; cl00259
1415784008992	Sm1 motif; other site
1415784008993	RNA binding site [nucleotide binding]; other site
1415784008994	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
1415784008995	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1415784008996	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1415784008997	dimer interface [polypeptide binding]; other site
1415784008998	phosphorylation site [posttranslational modification]
1415784008999	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784009000	ATP binding site [chemical binding]; other site
1415784009001	Mg2+ binding site [ion binding]; other site
1415784009002	G-X-G motif; other site
1415784009003	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
1415784009004	hypothetical protein; Provisional; Region: PRK06851
1415784009005	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1415784009006	Walker A motif; other site
1415784009007	ATP binding site [chemical binding]; other site
1415784009008	NTPase; Region: NTPase_1; cl17478
1415784009009	Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127
1415784009010	benzoate transport; Region: 2A0115; TIGR00895
1415784009011	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784009012	putative substrate translocation pore; other site
1415784009013	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784009014	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1415784009015	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1415784009016	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
1415784009017	YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477
1415784009018	[2Fe-2S] cluster binding site [ion binding]; other site
1415784009019	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1415784009020	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
1415784009021	putative di-iron ligands [ion binding]; other site
1415784009022	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784009023	dimer interface [polypeptide binding]; other site
1415784009024	conserved gate region; other site
1415784009025	putative PBP binding loops; other site
1415784009026	ABC-ATPase subunit interface; other site
1415784009027	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1415784009028	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1415784009029	substrate binding pocket [chemical binding]; other site
1415784009030	membrane-bound complex binding site; other site
1415784009031	hinge residues; other site
1415784009032	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1415784009033	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1415784009034	Walker A/P-loop; other site
1415784009035	ATP binding site [chemical binding]; other site
1415784009036	Q-loop/lid; other site
1415784009037	ABC transporter signature motif; other site
1415784009038	Walker B; other site
1415784009039	D-loop; other site
1415784009040	H-loop/switch region; other site
1415784009041	HAMP domain; Region: HAMP; pfam00672
1415784009042	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1415784009043	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1415784009044	dimer interface [polypeptide binding]; other site
1415784009045	putative CheW interface [polypeptide binding]; other site
1415784009046	Arginine repressor [Transcription]; Region: ArgR; COG1438
1415784009047	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1415784009048	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1415784009049	arginine deiminase; Provisional; Region: PRK01388
1415784009050	ornithine carbamoyltransferase; Validated; Region: PRK02102
1415784009051	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1415784009052	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1415784009053	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
1415784009054	carbamate kinase; Reviewed; Region: PRK12686
1415784009055	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
1415784009056	putative substrate binding site [chemical binding]; other site
1415784009057	nucleotide binding site [chemical binding]; other site
1415784009058	nucleotide binding site [chemical binding]; other site
1415784009059	homodimer interface [polypeptide binding]; other site
1415784009060	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1415784009061	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1415784009062	ligand binding site [chemical binding]; other site
1415784009063	flexible hinge region; other site
1415784009064	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1415784009065	putative switch regulator; other site
1415784009066	non-specific DNA interactions [nucleotide binding]; other site
1415784009067	DNA binding site [nucleotide binding]
1415784009068	sequence specific DNA binding site [nucleotide binding]; other site
1415784009069	putative cAMP binding site [chemical binding]; other site
1415784009070	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1415784009071	FAD binding domain; Region: FAD_binding_4; pfam01565
1415784009072	Berberine and berberine like; Region: BBE; pfam08031
1415784009073	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1415784009074	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1415784009075	Ca binding site [ion binding]; other site
1415784009076	active site
1415784009077	catalytic site [active]
1415784009078	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1415784009079	PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003
1415784009080	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1415784009081	active site turn [active]
1415784009082	phosphorylation site [posttranslational modification]
1415784009083	Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079
1415784009084	putative catalytic site [active]
1415784009085	putative metal binding site [ion binding]; other site
1415784009086	putative phosphate binding site [ion binding]; other site
1415784009087	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1415784009088	Predicted membrane protein [Function unknown]; Region: COG1511
1415784009089	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784009090	DNA topoisomerase III; Provisional; Region: PRK07726
1415784009091	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1415784009092	active site
1415784009093	putative interdomain interaction site [polypeptide binding]; other site
1415784009094	putative metal-binding site [ion binding]; other site
1415784009095	putative nucleotide binding site [chemical binding]; other site
1415784009096	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1415784009097	domain I; other site
1415784009098	DNA binding groove [nucleotide binding]
1415784009099	phosphate binding site [ion binding]; other site
1415784009100	domain II; other site
1415784009101	domain III; other site
1415784009102	nucleotide binding site [chemical binding]; other site
1415784009103	catalytic site [active]
1415784009104	domain IV; other site
1415784009105	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
1415784009106	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
1415784009107	substrate binding site [chemical binding]; other site
1415784009108	multimerization interface [polypeptide binding]; other site
1415784009109	ATP binding site [chemical binding]; other site
1415784009110	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1415784009111	thiamine phosphate binding site [chemical binding]; other site
1415784009112	active site
1415784009113	pyrophosphate binding site [ion binding]; other site
1415784009114	threonine dehydratase; Provisional; Region: PRK08198
1415784009115	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1415784009116	tetramer interface [polypeptide binding]; other site
1415784009117	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784009118	catalytic residue [active]
1415784009119	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
1415784009120	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
1415784009121	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
1415784009122	HAMP domain; Region: HAMP; pfam00672
1415784009123	dimerization interface [polypeptide binding]; other site
1415784009124	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1415784009125	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1415784009126	dimer interface [polypeptide binding]; other site
1415784009127	putative CheW interface [polypeptide binding]; other site
1415784009128	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1415784009129	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1415784009130	acyl-activating enzyme (AAE) consensus motif; other site
1415784009131	AMP binding site [chemical binding]; other site
1415784009132	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1415784009133	thioester reductase domain; Region: Thioester-redct; TIGR01746
1415784009134	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
1415784009135	putative NAD(P) binding site [chemical binding]; other site
1415784009136	active site
1415784009137	putative substrate binding site [chemical binding]; other site
1415784009138	Domain of unknown function DUF77; Region: DUF77; pfam01910
1415784009139	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1415784009140	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784009141	dimer interface [polypeptide binding]; other site
1415784009142	conserved gate region; other site
1415784009143	putative PBP binding loops; other site
1415784009144	ABC-ATPase subunit interface; other site
1415784009145	NMT1/THI5 like; Region: NMT1; pfam09084
1415784009146	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
1415784009147	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1415784009148	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1415784009149	Walker A/P-loop; other site
1415784009150	ATP binding site [chemical binding]; other site
1415784009151	Q-loop/lid; other site
1415784009152	ABC transporter signature motif; other site
1415784009153	Walker B; other site
1415784009154	D-loop; other site
1415784009155	H-loop/switch region; other site
1415784009156	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
1415784009157	Glyco_18 domain; Region: Glyco_18; smart00636
1415784009158	active site
1415784009159	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1415784009160	Interdomain contacts; other site
1415784009161	Cytokine receptor motif; other site
1415784009162	Cellulose binding domain; Region: CBM_2; pfam00553
1415784009163	Domain of unknown function (DUF1992); Region: DUF1992; pfam09350
1415784009164	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1415784009165	catalytic residues [active]
1415784009166	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1415784009167	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1415784009168	QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360
1415784009169	H+ Antiporter protein; Region: 2A0121; TIGR00900
1415784009170	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784009171	putative substrate translocation pore; other site
1415784009172	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1415784009173	non-specific DNA binding site [nucleotide binding]; other site
1415784009174	salt bridge; other site
1415784009175	sequence-specific DNA binding site [nucleotide binding]; other site
1415784009176	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
1415784009177	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784009178	putative substrate translocation pore; other site
1415784009179	Uncharacterized conserved protein [Function unknown]; Region: COG3379
1415784009180	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
1415784009181	YesK-like protein; Region: YesK; pfam14150
1415784009182	prolyl-tRNA synthetase; Provisional; Region: PRK08661
1415784009183	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
1415784009184	dimer interface [polypeptide binding]; other site
1415784009185	motif 1; other site
1415784009186	active site
1415784009187	motif 2; other site
1415784009188	motif 3; other site
1415784009189	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
1415784009190	anticodon binding site; other site
1415784009191	zinc-binding site [ion binding]; other site
1415784009192	Bacterial SH3 domain; Region: SH3_3; pfam08239
1415784009193	Bacterial SH3 domain; Region: SH3_3; pfam08239
1415784009194	Bacterial SH3 domain; Region: SH3_3; pfam08239
1415784009195	Bacterial SH3 domain; Region: SH3_3; pfam08239
1415784009196	Bacterial SH3 domain; Region: SH3_3; pfam08239
1415784009197	Bacterial SH3 domain; Region: SH3_3; pfam08239
1415784009198	Bacterial SH3 domain; Region: SH3_3; pfam08239
1415784009199	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
1415784009200	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1415784009201	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1415784009202	nucleotide binding site [chemical binding]; other site
1415784009203	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
1415784009204	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
1415784009205	putative metal binding site [ion binding]; other site
1415784009206	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
1415784009207	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
1415784009208	putative metal binding site [ion binding]; other site
1415784009209	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
1415784009210	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
1415784009211	putative metal binding site [ion binding]; other site
1415784009212	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
1415784009213	Domain of unknown function (DUF4356); Region: DUF4356; pfam14266
1415784009214	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
1415784009215	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1415784009216	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
1415784009217	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1415784009218	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1415784009219	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1415784009220	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1415784009221	Protein of unknown function (DUF1128); Region: DUF1128; pfam06569
1415784009222	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1415784009223	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1415784009224	active site
1415784009225	YtxH-like protein; Region: YtxH; cl02079
1415784009226	Domain of unknown function (DUF4075); Region: DUF4075; pfam13294
1415784009227	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
1415784009228	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
1415784009229	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1415784009230	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1415784009231	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1415784009232	EamA-like transporter family; Region: EamA; pfam00892
1415784009233	EamA-like transporter family; Region: EamA; pfam00892
1415784009234	YhhN-like protein; Region: YhhN; pfam07947
1415784009235	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1415784009236	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1415784009237	Catalytic site [active]
1415784009238	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1415784009239	binding surface
1415784009240	TPR motif; other site
1415784009241	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1415784009242	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1415784009243	Predicted membrane protein [Function unknown]; Region: COG2510
1415784009244	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
1415784009245	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1415784009246	calcium/proton exchanger (cax); Region: cax; TIGR00378
1415784009247	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1415784009248	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1415784009249	YfkD-like protein; Region: YfkD; pfam14167
1415784009250	Radical SAM superfamily; Region: Radical_SAM; pfam04055
1415784009251	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1415784009252	FeS/SAM binding site; other site
1415784009253	YfkB-like domain; Region: YfkB; pfam08756
1415784009254	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
1415784009255	Fumarase C-terminus; Region: Fumerase_C; pfam05683
1415784009256	Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948
1415784009257	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
1415784009258	NodB motif; other site
1415784009259	active site
1415784009260	catalytic site [active]
1415784009261	Cd binding site [ion binding]; other site
1415784009262	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1415784009263	endonuclease III; Region: ENDO3c; smart00478
1415784009264	minor groove reading motif; other site
1415784009265	helix-hairpin-helix signature motif; other site
1415784009266	substrate binding pocket [chemical binding]; other site
1415784009267	active site
1415784009268	TRAM domain; Region: TRAM; pfam01938
1415784009269	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
1415784009270	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784009271	S-adenosylmethionine binding site [chemical binding]; other site
1415784009272	tRNA pseudouridine synthase A; Reviewed; Region: PRK12434
1415784009273	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1415784009274	dimerization interface 3.5A [polypeptide binding]; other site
1415784009275	active site
1415784009276	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
1415784009277	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1415784009278	Walker A motif; other site
1415784009279	ATP binding site [chemical binding]; other site
1415784009280	Walker B motif; other site
1415784009281	arginine finger; other site
1415784009282	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1415784009283	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
1415784009284	hypothetical protein; Validated; Region: PRK06748
1415784009285	S-methylmethionine transporter; Provisional; Region: PRK11387
1415784009286	acetylornithine deacetylase; Validated; Region: PRK08596
1415784009287	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1415784009288	metal binding site [ion binding]; metal-binding site
1415784009289	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1415784009290	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1415784009291	non-specific DNA binding site [nucleotide binding]; other site
1415784009292	salt bridge; other site
1415784009293	sequence-specific DNA binding site [nucleotide binding]; other site
1415784009294	Protein of unknown function (DUF1232); Region: DUF1232; pfam06803
1415784009295	putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840
1415784009296	Protein of unknown function (DUF3969); Region: DUF3969; pfam13108
1415784009297	glutaminase A; Region: Gln_ase; TIGR03814
1415784009298	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
1415784009299	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
1415784009300	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1415784009301	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1415784009302	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1415784009303	active site turn [active]
1415784009304	phosphorylation site [posttranslational modification]
1415784009305	Beta-lactamase; Region: Beta-lactamase; pfam00144
1415784009306	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1415784009307	Sm and related proteins; Region: Sm_like; cl00259
1415784009308	heptamer interface [polypeptide binding]; other site
1415784009309	Sm1 motif; other site
1415784009310	hexamer interface [polypeptide binding]; other site
1415784009311	RNA binding site [nucleotide binding]; other site
1415784009312	Sm2 motif; other site
1415784009313	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
1415784009314	active site
1415784009315	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1415784009316	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
1415784009317	active site
1415784009318	nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026
1415784009319	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1415784009320	NAD(P) binding site [chemical binding]; other site
1415784009321	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1415784009322	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
1415784009323	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1415784009324	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1415784009325	NAD(P) binding site [chemical binding]; other site
1415784009326	active site
1415784009327	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1415784009328	active site
1415784009329	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1415784009330	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1415784009331	active site
1415784009332	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
1415784009333	Pyruvate formate lyase 1; Region: PFL1; cd01678
1415784009334	coenzyme A binding site [chemical binding]; other site
1415784009335	active site
1415784009336	catalytic residues [active]
1415784009337	glycine loop; other site
1415784009338	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
1415784009339	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1415784009340	FeS/SAM binding site; other site
1415784009341	diacylglycerol glucosyltransferase; Provisional; Region: PRK13609
1415784009342	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
1415784009343	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1415784009344	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1415784009345	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
1415784009346	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
1415784009347	active site
1415784009348	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
1415784009349	TIGR01777 family protein; Region: yfcH
1415784009350	putative NAD(P) binding site [chemical binding]; other site
1415784009351	putative active site [active]
1415784009352	RecX family; Region: RecX; cl00936
1415784009353	RecX family; Region: RecX; cl00936
1415784009354	Protein of unknown function (DUF1811); Region: DUF1811; pfam08838
1415784009355	YpzG-like protein; Region: YpzG; pfam14139
1415784009356	Small acid-soluble spore protein K family; Region: SspK; pfam08176
1415784009357	WVELL protein; Region: WVELL; pfam14043
1415784009358	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
1415784009359	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
1415784009360	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1415784009361	minor groove reading motif; other site
1415784009362	helix-hairpin-helix signature motif; other site
1415784009363	substrate binding pocket [chemical binding]; other site
1415784009364	active site
1415784009365	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
1415784009366	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
1415784009367	DNA binding and oxoG recognition site [nucleotide binding]
1415784009368	YgaB-like protein; Region: YgaB; pfam14182
1415784009369	hypothetical protein; Provisional; Region: PRK13662
1415784009370	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1415784009371	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1415784009372	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1415784009373	Walker A/P-loop; other site
1415784009374	ATP binding site [chemical binding]; other site
1415784009375	Q-loop/lid; other site
1415784009376	ABC transporter signature motif; other site
1415784009377	Walker B; other site
1415784009378	D-loop; other site
1415784009379	H-loop/switch region; other site
1415784009380	Predicted membrane protein [Function unknown]; Region: COG4129
1415784009381	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1415784009382	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1415784009383	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1415784009384	active site
1415784009385	dimer interface [polypeptide binding]; other site
1415784009386	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1415784009387	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1415784009388	active site
1415784009389	FMN binding site [chemical binding]; other site
1415784009390	substrate binding site [chemical binding]; other site
1415784009391	3Fe-4S cluster binding site [ion binding]; other site
1415784009392	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504
1415784009393	domain_subunit interface; other site
1415784009394	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389
1415784009395	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1415784009396	inhibitor-cofactor binding pocket; inhibition site
1415784009397	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784009398	catalytic residue [active]
1415784009399	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
1415784009400	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1415784009401	Walker A/P-loop; other site
1415784009402	ATP binding site [chemical binding]; other site
1415784009403	Q-loop/lid; other site
1415784009404	ABC transporter signature motif; other site
1415784009405	Walker B; other site
1415784009406	D-loop; other site
1415784009407	H-loop/switch region; other site
1415784009408	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
1415784009409	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
1415784009410	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
1415784009411	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
1415784009412	Ion channel; Region: Ion_trans_2; pfam07885
1415784009413	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1415784009414	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1415784009415	catalytic triad [active]
1415784009416	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1415784009417	metal binding site 2 [ion binding]; metal-binding site
1415784009418	putative DNA binding helix; other site
1415784009419	metal binding site 1 [ion binding]; metal-binding site
1415784009420	dimer interface [polypeptide binding]; other site
1415784009421	structural Zn2+ binding site [ion binding]; other site
1415784009422	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784009423	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1415784009424	Coenzyme A binding pocket [chemical binding]; other site
1415784009425	Protein of unknown function (DUF2614); Region: DUF2614; pfam11023
1415784009426	Protein of unknown function (DUF3884); Region: DUF3884; pfam13024
1415784009427	hypothetical protein; Provisional; Region: PRK12378
1415784009428	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1415784009429	nudix motif; other site
1415784009430	Transglycosylase; Region: Transgly; pfam00912
1415784009431	Thioredoxin; Region: Thioredoxin_4; pfam13462
1415784009432	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
1415784009433	epoxyqueuosine reductase; Region: TIGR00276
1415784009434	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
1415784009435	Putative amidase domain; Region: Amidase_6; pfam12671
1415784009436	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1415784009437	PAS fold; Region: PAS_4; pfam08448
1415784009438	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1415784009439	putative active site [active]
1415784009440	heme pocket [chemical binding]; other site
1415784009441	PAS domain S-box; Region: sensory_box; TIGR00229
1415784009442	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1415784009443	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1415784009444	metal binding site [ion binding]; metal-binding site
1415784009445	active site
1415784009446	I-site; other site
1415784009447	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1415784009448	Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766
1415784009449	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
1415784009450	sporulation protein YhbH; Region: spore_yhbH; TIGR02877
1415784009451	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1415784009452	heme-binding site [chemical binding]; other site
1415784009453	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1415784009454	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1415784009455	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1415784009456	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1415784009457	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1415784009458	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1415784009459	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1415784009460	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1415784009461	Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453
1415784009462	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
1415784009463	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
1415784009464	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
1415784009465	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
1415784009466	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
1415784009467	Tar ligand binding domain homologue; Region: TarH; pfam02203
1415784009468	Cache domain; Region: Cache_1; pfam02743
1415784009469	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1415784009470	dimerization interface [polypeptide binding]; other site
1415784009471	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1415784009472	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1415784009473	dimer interface [polypeptide binding]; other site
1415784009474	putative CheW interface [polypeptide binding]; other site
1415784009475	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1415784009476	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1415784009477	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784009478	ATP binding site [chemical binding]; other site
1415784009479	Mg2+ binding site [ion binding]; other site
1415784009480	G-X-G motif; other site
1415784009481	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
1415784009482	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784009483	active site
1415784009484	phosphorylation site [posttranslational modification]
1415784009485	intermolecular recognition site; other site
1415784009486	dimerization interface [polypeptide binding]; other site
1415784009487	H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620
1415784009488	Citrate transporter; Region: CitMHS; pfam03600
1415784009489	hypothetical protein; Provisional; Region: PRK12784
1415784009490	NosL; Region: NosL; cl01769
1415784009491	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1415784009492	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529
1415784009493	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1415784009494	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1415784009495	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852
1415784009496	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1415784009497	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1415784009498	Walker A/P-loop; other site
1415784009499	ATP binding site [chemical binding]; other site
1415784009500	Q-loop/lid; other site
1415784009501	ABC transporter signature motif; other site
1415784009502	Walker B; other site
1415784009503	D-loop; other site
1415784009504	H-loop/switch region; other site
1415784009505	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1415784009506	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784009507	dimer interface [polypeptide binding]; other site
1415784009508	conserved gate region; other site
1415784009509	putative PBP binding loops; other site
1415784009510	ABC-ATPase subunit interface; other site
1415784009511	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1415784009512	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1415784009513	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784009514	dimer interface [polypeptide binding]; other site
1415784009515	conserved gate region; other site
1415784009516	putative PBP binding loops; other site
1415784009517	ABC-ATPase subunit interface; other site
1415784009518	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1415784009519	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1415784009520	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1415784009521	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
1415784009522	active site
1415784009523	metal binding site [ion binding]; metal-binding site
1415784009524	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1415784009525	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784009526	active site
1415784009527	phosphorylation site [posttranslational modification]
1415784009528	intermolecular recognition site; other site
1415784009529	dimerization interface [polypeptide binding]; other site
1415784009530	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1415784009531	DNA binding site [nucleotide binding]
1415784009532	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1415784009533	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1415784009534	dimer interface [polypeptide binding]; other site
1415784009535	phosphorylation site [posttranslational modification]
1415784009536	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784009537	ATP binding site [chemical binding]; other site
1415784009538	Mg2+ binding site [ion binding]; other site
1415784009539	G-X-G motif; other site
1415784009540	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
1415784009541	putative active site [active]
1415784009542	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
1415784009543	Cache domain; Region: Cache_1; pfam02743
1415784009544	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1415784009545	dimerization interface [polypeptide binding]; other site
1415784009546	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1415784009547	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1415784009548	dimer interface [polypeptide binding]; other site
1415784009549	putative CheW interface [polypeptide binding]; other site
1415784009550	sensory histidine kinase DcuS; Provisional; Region: PRK11086
1415784009551	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784009552	ATP binding site [chemical binding]; other site
1415784009553	Mg2+ binding site [ion binding]; other site
1415784009554	G-X-G motif; other site
1415784009555	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
1415784009556	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784009557	active site
1415784009558	phosphorylation site [posttranslational modification]
1415784009559	intermolecular recognition site; other site
1415784009560	dimerization interface [polypeptide binding]; other site
1415784009561	2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390
1415784009562	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
1415784009563	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1415784009564	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1415784009565	putative NAD(P) binding site [chemical binding]; other site
1415784009566	EamA-like transporter family; Region: EamA; pfam00892
1415784009567	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1415784009568	EamA-like transporter family; Region: EamA; pfam00892
1415784009569	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1415784009570	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1415784009571	DNA-binding site [nucleotide binding]; DNA binding site
1415784009572	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1415784009573	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784009574	homodimer interface [polypeptide binding]; other site
1415784009575	catalytic residue [active]
1415784009576	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
1415784009577	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784009578	Coenzyme A binding pocket [chemical binding]; other site
1415784009579	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1415784009580	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1415784009581	dimerization interface [polypeptide binding]; other site
1415784009582	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1415784009583	dimer interface [polypeptide binding]; other site
1415784009584	phosphorylation site [posttranslational modification]
1415784009585	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784009586	ATP binding site [chemical binding]; other site
1415784009587	Mg2+ binding site [ion binding]; other site
1415784009588	G-X-G motif; other site
1415784009589	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1415784009590	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784009591	active site
1415784009592	phosphorylation site [posttranslational modification]
1415784009593	intermolecular recognition site; other site
1415784009594	dimerization interface [polypeptide binding]; other site
1415784009595	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1415784009596	DNA binding site [nucleotide binding]
1415784009597	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
1415784009598	Arrestin_N terminal like; Region: LDB19; pfam13002
1415784009599	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784009600	Coenzyme A binding pocket [chemical binding]; other site
1415784009601	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
1415784009602	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
1415784009603	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1415784009604	catalytic loop [active]
1415784009605	iron binding site [ion binding]; other site
1415784009606	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1415784009607	4Fe-4S binding domain; Region: Fer4; pfam00037
1415784009608	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
1415784009609	[4Fe-4S] binding site [ion binding]; other site
1415784009610	molybdopterin cofactor binding site; other site
1415784009611	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
1415784009612	molybdopterin cofactor binding site; other site
1415784009613	Uncharacterized conserved protein [Function unknown]; Region: COG2427
1415784009614	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110
1415784009615	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1415784009616	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
1415784009617	putative active site [active]
1415784009618	catalytic site [active]
1415784009619	putative metal binding site [ion binding]; other site
1415784009620	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1415784009621	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1415784009622	hexamer interface [polypeptide binding]; other site
1415784009623	ligand binding site [chemical binding]; other site
1415784009624	putative active site [active]
1415784009625	NAD(P) binding site [chemical binding]; other site
1415784009626	amino acid transporter; Region: 2A0306; TIGR00909
1415784009627	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1415784009628	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
1415784009629	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1415784009630	dimerization interface [polypeptide binding]; other site
1415784009631	putative DNA binding site [nucleotide binding]; other site
1415784009632	putative Zn2+ binding site [ion binding]; other site
1415784009633	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1415784009634	metal-binding site [ion binding]
1415784009635	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1415784009636	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1415784009637	metal-binding site [ion binding]
1415784009638	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1415784009639	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1415784009640	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
1415784009641	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
1415784009642	active site
1415784009643	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1415784009644	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1415784009645	non-specific DNA binding site [nucleotide binding]; other site
1415784009646	salt bridge; other site
1415784009647	sequence-specific DNA binding site [nucleotide binding]; other site
1415784009648	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1415784009649	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1415784009650	binding surface
1415784009651	TPR motif; other site
1415784009652	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1415784009653	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
1415784009654	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1415784009655	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
1415784009656	active site
1415784009657	Zn binding site [ion binding]; other site
1415784009658	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1415784009659	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1415784009660	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
1415784009661	VanW like protein; Region: VanW; pfam04294
1415784009662	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
1415784009663	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1415784009664	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1415784009665	Nucleoside recognition; Region: Gate; pfam07670
1415784009666	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1415784009667	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
1415784009668	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1415784009669	putative metal binding site [ion binding]; other site
1415784009670	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1415784009671	Domain of unknown function DUF21; Region: DUF21; pfam01595
1415784009672	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1415784009673	Transporter associated domain; Region: CorC_HlyC; smart01091
1415784009674	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
1415784009675	Aspartase; Region: Aspartase; cd01357
1415784009676	active sites [active]
1415784009677	tetramer interface [polypeptide binding]; other site
1415784009678	L-lactate permease; Region: Lactate_perm; cl00701
1415784009679	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
1415784009680	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1415784009681	dimerization interface [polypeptide binding]; other site
1415784009682	putative Zn2+ binding site [ion binding]; other site
1415784009683	putative DNA binding site [nucleotide binding]; other site
1415784009684	Small acid-soluble spore protein H family; Region: SspH; cl06949
1415784009685	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1415784009686	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784009687	putative substrate translocation pore; other site
1415784009688	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1415784009689	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1415784009690	siderophore binding site; other site
1415784009691	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1415784009692	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1415784009693	ABC-ATPase subunit  interface; other site
1415784009694	dimer interface [polypeptide binding]; other site
1415784009695	putative PBP binding regions; other site
1415784009696	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1415784009697	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1415784009698	ABC-ATPase subunit  interface; other site
1415784009699	dimer interface [polypeptide binding]; other site
1415784009700	putative PBP binding regions; other site
1415784009701	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1415784009702	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1415784009703	Walker A/P-loop; other site
1415784009704	ATP binding site [chemical binding]; other site
1415784009705	Q-loop/lid; other site
1415784009706	ABC transporter signature motif; other site
1415784009707	Walker B; other site
1415784009708	D-loop; other site
1415784009709	H-loop/switch region; other site
1415784009710	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1415784009711	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784009712	S-adenosylmethionine binding site [chemical binding]; other site
1415784009713	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1415784009714	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1415784009715	substrate-cofactor binding pocket; other site
1415784009716	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784009717	catalytic residue [active]
1415784009718	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1415784009719	L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272
1415784009720	NAD binding site [chemical binding]; other site
1415784009721	homodimer interface [polypeptide binding]; other site
1415784009722	active site
1415784009723	putative substrate binding site [chemical binding]; other site
1415784009724	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1415784009725	nudix motif; other site
1415784009726	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
1415784009727	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
1415784009728	metal ion-dependent adhesion site (MIDAS); other site
1415784009729	MoxR-like ATPases [General function prediction only]; Region: COG0714
1415784009730	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1415784009731	Walker A motif; other site
1415784009732	ATP binding site [chemical binding]; other site
1415784009733	Walker B motif; other site
1415784009734	arginine finger; other site
1415784009735	cardiolipin synthetase; Reviewed; Region: PRK12452
1415784009736	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1415784009737	putative active site [active]
1415784009738	catalytic site [active]
1415784009739	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1415784009740	putative active site [active]
1415784009741	catalytic site [active]
1415784009742	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1415784009743	PAS domain; Region: PAS_9; pfam13426
1415784009744	putative active site [active]
1415784009745	heme pocket [chemical binding]; other site
1415784009746	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1415784009747	metal binding site [ion binding]; metal-binding site
1415784009748	active site
1415784009749	I-site; other site
1415784009750	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1415784009751	putrescine transporter; Provisional; Region: potE; PRK10655
1415784009752	Spore germination protein; Region: Spore_permease; cl17796
1415784009753	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1415784009754	DNA-binding site [nucleotide binding]; DNA binding site
1415784009755	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
1415784009756	UTRA domain; Region: UTRA; pfam07702
1415784009757	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
1415784009758	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1415784009759	active site turn [active]
1415784009760	phosphorylation site [posttranslational modification]
1415784009761	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1415784009762	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1415784009763	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1415784009764	Ca binding site [ion binding]; other site
1415784009765	active site
1415784009766	catalytic site [active]
1415784009767	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1415784009768	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1415784009769	Spore germination protein; Region: Spore_permease; cl17796
1415784009770	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1415784009771	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1415784009772	GAF domain; Region: GAF_3; pfam13492
1415784009773	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1415784009774	Histidine kinase; Region: HisKA_3; pfam07730
1415784009775	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784009776	ATP binding site [chemical binding]; other site
1415784009777	Mg2+ binding site [ion binding]; other site
1415784009778	G-X-G motif; other site
1415784009779	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1415784009780	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784009781	active site
1415784009782	phosphorylation site [posttranslational modification]
1415784009783	intermolecular recognition site; other site
1415784009784	dimerization interface [polypeptide binding]; other site
1415784009785	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1415784009786	DNA binding residues [nucleotide binding]
1415784009787	dimerization interface [polypeptide binding]; other site
1415784009788	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
1415784009789	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
1415784009790	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
1415784009791	putative active site [active]
1415784009792	catalytic triad [active]
1415784009793	PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133
1415784009794	PA/protease domain interface [polypeptide binding]; other site
1415784009795	putative integrin binding motif; other site
1415784009796	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
1415784009797	Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547
1415784009798	dockerin binding interface; other site
1415784009799	Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780
1415784009800	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1415784009801	active site
1415784009802	ATP binding site [chemical binding]; other site
1415784009803	substrate binding site [chemical binding]; other site
1415784009804	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1415784009805	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
1415784009806	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1415784009807	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1415784009808	Walker A/P-loop; other site
1415784009809	ATP binding site [chemical binding]; other site
1415784009810	Q-loop/lid; other site
1415784009811	ABC transporter signature motif; other site
1415784009812	Walker B; other site
1415784009813	D-loop; other site
1415784009814	H-loop/switch region; other site
1415784009815	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1415784009816	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1415784009817	substrate binding pocket [chemical binding]; other site
1415784009818	membrane-bound complex binding site; other site
1415784009819	hinge residues; other site
1415784009820	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1415784009821	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784009822	dimer interface [polypeptide binding]; other site
1415784009823	conserved gate region; other site
1415784009824	putative PBP binding loops; other site
1415784009825	ABC-ATPase subunit interface; other site
1415784009826	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784009827	dimer interface [polypeptide binding]; other site
1415784009828	conserved gate region; other site
1415784009829	putative PBP binding loops; other site
1415784009830	ABC-ATPase subunit interface; other site
1415784009831	S-methylmethionine transporter; Provisional; Region: PRK11387
1415784009832	OsmC-like protein; Region: OsmC; pfam02566
1415784009833	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
1415784009834	nucleotide binding site/active site [active]
1415784009835	HIT family signature motif; other site
1415784009836	catalytic residue [active]
1415784009837	RNA polymerase sigma factor; Provisional; Region: PRK12542
1415784009838	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1415784009839	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1415784009840	DNA binding residues [nucleotide binding]
1415784009841	Domain of unknown function (DUF4367); Region: DUF4367; pfam14285
1415784009842	Predicted transcriptional regulator [Transcription]; Region: COG2378
1415784009843	HTH domain; Region: HTH_11; pfam08279
1415784009844	WYL domain; Region: WYL; pfam13280
1415784009845	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1415784009846	RibD C-terminal domain; Region: RibD_C; cl17279
1415784009847	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1415784009848	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1415784009849	dimerization interface [polypeptide binding]; other site
1415784009850	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1415784009851	dimer interface [polypeptide binding]; other site
1415784009852	phosphorylation site [posttranslational modification]
1415784009853	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784009854	ATP binding site [chemical binding]; other site
1415784009855	Mg2+ binding site [ion binding]; other site
1415784009856	G-X-G motif; other site
1415784009857	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1415784009858	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784009859	active site
1415784009860	phosphorylation site [posttranslational modification]
1415784009861	intermolecular recognition site; other site
1415784009862	dimerization interface [polypeptide binding]; other site
1415784009863	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1415784009864	DNA binding site [nucleotide binding]
1415784009865	Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247
1415784009866	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1415784009867	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1415784009868	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1415784009869	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1415784009870	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1415784009871	Ligand Binding Site [chemical binding]; other site
1415784009872	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
1415784009873	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784009874	putative substrate translocation pore; other site
1415784009875	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1415784009876	MarR family; Region: MarR; pfam01047
1415784009877	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1415784009878	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784009879	putative substrate translocation pore; other site
1415784009880	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1415784009881	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1415784009882	DNA binding site [nucleotide binding]
1415784009883	domain linker motif; other site
1415784009884	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
1415784009885	dimerization interface [polypeptide binding]; other site
1415784009886	ligand binding site [chemical binding]; other site
1415784009887	sodium binding site [ion binding]; other site
1415784009888	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1415784009889	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1415784009890	substrate binding site [chemical binding]; other site
1415784009891	dimer interface [polypeptide binding]; other site
1415784009892	ATP binding site [chemical binding]; other site
1415784009893	D-ribose pyranase; Provisional; Region: PRK11797
1415784009894	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1415784009895	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1415784009896	Walker A/P-loop; other site
1415784009897	ATP binding site [chemical binding]; other site
1415784009898	Q-loop/lid; other site
1415784009899	ABC transporter signature motif; other site
1415784009900	Walker B; other site
1415784009901	D-loop; other site
1415784009902	H-loop/switch region; other site
1415784009903	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1415784009904	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1415784009905	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1415784009906	TM-ABC transporter signature motif; other site
1415784009907	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
1415784009908	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1415784009909	ligand binding site [chemical binding]; other site
1415784009910	dimerization interface [polypeptide binding]; other site
1415784009911	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
1415784009912	active site
1415784009913	intersubunit interactions; other site
1415784009914	catalytic residue [active]
1415784009915	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412
1415784009916	Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547
1415784009917	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784009918	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1415784009919	putative substrate translocation pore; other site
1415784009920	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
1415784009921	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1415784009922	putative NAD(P) binding site [chemical binding]; other site
1415784009923	catalytic Zn binding site [ion binding]; other site
1415784009924	Ion channel; Region: Ion_trans_2; pfam07885
1415784009925	Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009
1415784009926	Zn binding site [ion binding]; other site
1415784009927	Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078
1415784009928	putative catalytic site [active]
1415784009929	metal binding site A [ion binding]; metal-binding site
1415784009930	phosphate binding site [ion binding]; other site
1415784009931	metal binding site C [ion binding]; metal-binding site
1415784009932	metal binding site B [ion binding]; metal-binding site
1415784009933	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813
1415784009934	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
1415784009935	dimer interface [polypeptide binding]; other site
1415784009936	active site
1415784009937	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1415784009938	substrate binding site [chemical binding]; other site
1415784009939	catalytic residue [active]
1415784009940	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
1415784009941	FAD binding domain; Region: FAD_binding_4; pfam01565
1415784009942	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
1415784009943	VanZ like family; Region: VanZ; pfam04892
1415784009944	RDD family; Region: RDD; pfam06271
1415784009945	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
1415784009946	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
1415784009947	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1415784009948	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1415784009949	dimer interface [polypeptide binding]; other site
1415784009950	putative CheW interface [polypeptide binding]; other site
1415784009951	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
1415784009952	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
1415784009953	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1415784009954	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1415784009955	non-specific DNA binding site [nucleotide binding]; other site
1415784009956	salt bridge; other site
1415784009957	sequence-specific DNA binding site [nucleotide binding]; other site
1415784009958	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
1415784009959	active site
1415784009960	catalytic site [active]
1415784009961	POT family; Region: PTR2; cl17359
1415784009962	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784009963	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1415784009964	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cl09943
1415784009965	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
1415784009966	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
1415784009967	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1415784009968	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
1415784009969	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1415784009970	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1415784009971	non-specific DNA binding site [nucleotide binding]; other site
1415784009972	salt bridge; other site
1415784009973	sequence-specific DNA binding site [nucleotide binding]; other site
1415784009974	Protein of unknown function (DUF4022); Region: DUF4022; pfam13214
1415784009975	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1415784009976	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1415784009977	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1415784009978	TrkA-N domain; Region: TrkA_N; pfam02254
1415784009979	TrkA-C domain; Region: TrkA_C; pfam02080
1415784009980	cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901
1415784009981	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
1415784009982	Subunit I/III interface [polypeptide binding]; other site
1415784009983	Subunit III/IV interface [polypeptide binding]; other site
1415784009984	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1415784009985	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1415784009986	D-pathway; other site
1415784009987	Putative ubiquinol binding site [chemical binding]; other site
1415784009988	Low-spin heme (heme b) binding site [chemical binding]; other site
1415784009989	Putative water exit pathway; other site
1415784009990	Binuclear center (heme o3/CuB) [ion binding]; other site
1415784009991	K-pathway; other site
1415784009992	Putative proton exit pathway; other site
1415784009993	cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432
1415784009994	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
1415784009995	S-methylmethionine transporter; Provisional; Region: PRK11387
1415784009996	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
1415784009997	putative active site [active]
1415784009998	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1415784009999	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
1415784010000	metal binding site [ion binding]; metal-binding site
1415784010001	dimer interface [polypeptide binding]; other site
1415784010002	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
1415784010003	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
1415784010004	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1415784010005	Na binding site [ion binding]; other site
1415784010006	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1415784010007	spore germination protein (amino acid permease); Region: 2A0309; TIGR00912
1415784010008	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1415784010009	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1415784010010	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
1415784010011	Nucleoside recognition; Region: Gate; pfam07670
1415784010012	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
1415784010013	Nucleoside recognition; Region: Gate; pfam07670
1415784010014	Ferrous iron transport protein B; Region: FeoB_N; pfam02421
1415784010015	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
1415784010016	G1 box; other site
1415784010017	GTP/Mg2+ binding site [chemical binding]; other site
1415784010018	Switch I region; other site
1415784010019	G2 box; other site
1415784010020	G3 box; other site
1415784010021	Switch II region; other site
1415784010022	G4 box; other site
1415784010023	G5 box; other site
1415784010024	FeoA domain; Region: FeoA; pfam04023
1415784010025	phosphate binding protein; Region: ptsS_2; TIGR02136
1415784010026	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
1415784010027	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784010028	dimer interface [polypeptide binding]; other site
1415784010029	conserved gate region; other site
1415784010030	putative PBP binding loops; other site
1415784010031	ABC-ATPase subunit interface; other site
1415784010032	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
1415784010033	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784010034	dimer interface [polypeptide binding]; other site
1415784010035	conserved gate region; other site
1415784010036	putative PBP binding loops; other site
1415784010037	ABC-ATPase subunit interface; other site
1415784010038	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1415784010039	Protein export membrane protein; Region: SecD_SecF; cl14618
1415784010040	Protein export membrane protein; Region: SecD_SecF; cl14618
1415784010041	FOG: CBS domain [General function prediction only]; Region: COG0517
1415784010042	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
1415784010043	Domain of unknown function (DUF3960); Region: DUF3960; pfam13142
1415784010044	Protein of unknown function (DUF3965); Region: DUF3965; pfam13112
1415784010045	Bacterial SH3 domain; Region: SH3_3; pfam08239
1415784010046	Bacterial SH3 domain; Region: SH3_3; pfam08239
1415784010047	Bacterial SH3 domain; Region: SH3_3; pfam08239
1415784010048	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1415784010049	Peptidase family M23; Region: Peptidase_M23; pfam01551
1415784010050	Putative transcription activator [Transcription]; Region: TenA; COG0819
1415784010051	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1415784010052	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1415784010053	Walker A/P-loop; other site
1415784010054	ATP binding site [chemical binding]; other site
1415784010055	Q-loop/lid; other site
1415784010056	ABC transporter signature motif; other site
1415784010057	Walker B; other site
1415784010058	D-loop; other site
1415784010059	H-loop/switch region; other site
1415784010060	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1415784010061	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784010062	dimer interface [polypeptide binding]; other site
1415784010063	conserved gate region; other site
1415784010064	putative PBP binding loops; other site
1415784010065	ABC-ATPase subunit interface; other site
1415784010066	NMT1/THI5 like; Region: NMT1; pfam09084
1415784010067	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
1415784010068	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1415784010069	thiamine phosphate binding site [chemical binding]; other site
1415784010070	active site
1415784010071	pyrophosphate binding site [ion binding]; other site
1415784010072	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
1415784010073	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1415784010074	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
1415784010075	thiS-thiF/thiG interaction site; other site
1415784010076	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
1415784010077	ThiS interaction site; other site
1415784010078	putative active site [active]
1415784010079	tetramer interface [polypeptide binding]; other site
1415784010080	thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688
1415784010081	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1415784010082	ATP binding site [chemical binding]; other site
1415784010083	substrate interface [chemical binding]; other site
1415784010084	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1415784010085	dimer interface [polypeptide binding]; other site
1415784010086	substrate binding site [chemical binding]; other site
1415784010087	ATP binding site [chemical binding]; other site
1415784010088	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
1415784010089	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
1415784010090	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1415784010091	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1415784010092	potassium-transporting ATPase subunit C; Provisional; Region: PRK13997
1415784010093	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
1415784010094	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
1415784010095	Ligand Binding Site [chemical binding]; other site
1415784010096	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784010097	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1415784010098	putative substrate translocation pore; other site
1415784010099	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1415784010100	MarR family; Region: MarR; pfam01047
1415784010101	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
1415784010102	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
1415784010103	active site
1415784010104	nucleophile elbow; other site
1415784010105	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
1415784010106	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1415784010107	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1415784010108	TM-ABC transporter signature motif; other site
1415784010109	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1415784010110	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1415784010111	Walker A/P-loop; other site
1415784010112	ATP binding site [chemical binding]; other site
1415784010113	Q-loop/lid; other site
1415784010114	ABC transporter signature motif; other site
1415784010115	Walker B; other site
1415784010116	D-loop; other site
1415784010117	H-loop/switch region; other site
1415784010118	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1415784010119	Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305
1415784010120	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1415784010121	putative ligand binding site [chemical binding]; other site
1415784010122	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1415784010123	short chain dehydrogenase; Provisional; Region: PRK06701
1415784010124	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
1415784010125	NAD binding site [chemical binding]; other site
1415784010126	metal binding site [ion binding]; metal-binding site
1415784010127	active site
1415784010128	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1415784010129	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1415784010130	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
1415784010131	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1415784010132	catalytic residues [active]
1415784010133	putative disulfide oxidoreductase; Provisional; Region: PRK03113
1415784010134	YhdB-like protein; Region: YhdB; pfam14148
1415784010135	Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798
1415784010136	Spore germination protein; Region: Spore_permease; pfam03845
1415784010137	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1415784010138	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1415784010139	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1415784010140	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
1415784010141	putative FMN binding site [chemical binding]; other site
1415784010142	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
1415784010143	SpoVR like protein; Region: SpoVR; pfam04293
1415784010144	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
1415784010145	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1415784010146	putative DNA binding site [nucleotide binding]; other site
1415784010147	putative Zn2+ binding site [ion binding]; other site
1415784010148	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1415784010149	Protein of unknown function (DUF3238); Region: DUF3238; pfam11579
1415784010150	Protein of unknown function (DUF3238); Region: DUF3238; pfam11579
1415784010151	Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155
1415784010152	putative homodimer interface [polypeptide binding]; other site
1415784010153	putative homotetramer interface [polypeptide binding]; other site
1415784010154	putative metal binding site [ion binding]; other site
1415784010155	putative homodimer-homodimer interface [polypeptide binding]; other site
1415784010156	putative allosteric switch controlling residues; other site
1415784010157	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
1415784010158	CPxP  motif; other site
1415784010159	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1415784010160	active site residue [active]
1415784010161	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1415784010162	active site residue [active]
1415784010163	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1415784010164	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
1415784010165	CPxP  motif; other site
1415784010166	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1415784010167	active site residue [active]
1415784010168	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1415784010169	active site residue [active]
1415784010170	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
1415784010171	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1415784010172	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
1415784010173	Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280
1415784010174	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
1415784010175	NADP binding site [chemical binding]; other site
1415784010176	dimer interface [polypeptide binding]; other site
1415784010177	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
1415784010178	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1415784010179	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1415784010180	PhoU domain; Region: PhoU; pfam01895
1415784010181	PhoU domain; Region: PhoU; pfam01895
1415784010182	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784010183	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1415784010184	putative substrate translocation pore; other site
1415784010185	Uncharacterized conserved protein [Function unknown]; Region: COG3589
1415784010186	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
1415784010187	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1415784010188	HTH domain; Region: HTH_11; pfam08279
1415784010189	Mga helix-turn-helix domain; Region: Mga; pfam05043
1415784010190	PRD domain; Region: PRD; pfam00874
1415784010191	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1415784010192	active site
1415784010193	P-loop; other site
1415784010194	phosphorylation site [posttranslational modification]
1415784010195	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1415784010196	active site
1415784010197	phosphorylation site [posttranslational modification]
1415784010198	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1415784010199	active site
1415784010200	methionine cluster; other site
1415784010201	phosphorylation site [posttranslational modification]
1415784010202	metal binding site [ion binding]; metal-binding site
1415784010203	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1415784010204	active site
1415784010205	P-loop; other site
1415784010206	phosphorylation site [posttranslational modification]
1415784010207	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1415784010208	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1415784010209	Uncharacterized conserved protein [Function unknown]; Region: COG3589
1415784010210	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
1415784010211	Bacterial SH3 domain; Region: SH3_3; pfam08239
1415784010212	Bacterial SH3 domain; Region: SH3_3; pfam08239
1415784010213	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
1415784010214	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1415784010215	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1415784010216	FtsX-like permease family; Region: FtsX; pfam02687
1415784010217	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1415784010218	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1415784010219	Walker A/P-loop; other site
1415784010220	ATP binding site [chemical binding]; other site
1415784010221	Q-loop/lid; other site
1415784010222	ABC transporter signature motif; other site
1415784010223	Walker B; other site
1415784010224	D-loop; other site
1415784010225	H-loop/switch region; other site
1415784010226	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1415784010227	HlyD family secretion protein; Region: HlyD_3; pfam13437
1415784010228	conserved hypothetical integral membrane protein TIGR02206; Region: intg_mem_TP0381
1415784010229	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784010230	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1415784010231	dimer interface [polypeptide binding]; other site
1415784010232	conserved gate region; other site
1415784010233	putative PBP binding loops; other site
1415784010234	ABC-ATPase subunit interface; other site
1415784010235	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1415784010236	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784010237	dimer interface [polypeptide binding]; other site
1415784010238	conserved gate region; other site
1415784010239	ABC-ATPase subunit interface; other site
1415784010240	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1415784010241	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
1415784010242	dimanganese center [ion binding]; other site
1415784010243	CotJB protein; Region: CotJB; pfam12652
1415784010244	Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007
1415784010245	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1415784010246	active site
1415784010247	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
1415784010248	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
1415784010249	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
1415784010250	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
1415784010251	putative DNA binding site [nucleotide binding]; other site
1415784010252	putative homodimer interface [polypeptide binding]; other site
1415784010253	Uncharacterized conserved protein [Function unknown]; Region: COG3339
1415784010254	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1415784010255	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1415784010256	Protein of unknown function (DUF3992); Region: DUF3992; pfam13157
1415784010257	Protein of unknown function (DUF3992); Region: DUF3992; pfam13157
1415784010258	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1415784010259	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1415784010260	active site
1415784010261	metal binding site [ion binding]; metal-binding site
1415784010262	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1415784010263	Interdomain contacts; other site
1415784010264	Cytokine receptor motif; other site
1415784010265	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
1415784010266	amino acid transporter; Region: 2A0306; TIGR00909
1415784010267	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1415784010268	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1415784010269	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1415784010270	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1415784010271	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1415784010272	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1415784010273	putative active site [active]
1415784010274	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
1415784010275	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
1415784010276	putative active site [active]
1415784010277	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1415784010278	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1415784010279	active site turn [active]
1415784010280	phosphorylation site [posttranslational modification]
1415784010281	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1415784010282	Uncharacterized conserved protein [Function unknown]; Region: COG3589
1415784010283	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
1415784010284	DoxX; Region: DoxX; pfam07681
1415784010285	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
1415784010286	hypothetical protein; Provisional; Region: PRK06770
1415784010287	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1415784010288	EamA-like transporter family; Region: EamA; pfam00892
1415784010289	EamA-like transporter family; Region: EamA; pfam00892
1415784010290	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1415784010291	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
1415784010292	AsnC family; Region: AsnC_trans_reg; pfam01037
1415784010293	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784010294	Coenzyme A binding pocket [chemical binding]; other site
1415784010295	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06077
1415784010296	classical (c) SDRs; Region: SDR_c; cd05233
1415784010297	NAD(P) binding site [chemical binding]; other site
1415784010298	active site
1415784010299	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1415784010300	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1415784010301	DNA binding residues [nucleotide binding]
1415784010302	putative dimer interface [polypeptide binding]; other site
1415784010303	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1415784010304	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1415784010305	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1415784010306	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1415784010307	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1415784010308	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1415784010309	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1415784010310	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1415784010311	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784010312	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784010313	Predicted transcriptional regulators [Transcription]; Region: COG1733
1415784010314	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1415784010315	dimerization interface [polypeptide binding]; other site
1415784010316	putative DNA binding site [nucleotide binding]; other site
1415784010317	putative Zn2+ binding site [ion binding]; other site
1415784010318	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
1415784010319	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1415784010320	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
1415784010321	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
1415784010322	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
1415784010323	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
1415784010324	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1415784010325	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784010326	putative substrate translocation pore; other site
1415784010327	intracellular protease, PfpI family; Region: PfpI; TIGR01382
1415784010328	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
1415784010329	proposed catalytic triad [active]
1415784010330	conserved cys residue [active]
1415784010331	Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975
1415784010332	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
1415784010333	Spore germination protein; Region: Spore_permease; cl17796
1415784010334	glutamate racemase; Provisional; Region: PRK00865
1415784010335	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412
1415784010336	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
1415784010337	tetrameric interface [polypeptide binding]; other site
1415784010338	activator binding site; other site
1415784010339	NADP binding site [chemical binding]; other site
1415784010340	substrate binding site [chemical binding]; other site
1415784010341	catalytic residues [active]
1415784010342	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1415784010343	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
1415784010344	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1415784010345	Walker A/P-loop; other site
1415784010346	ATP binding site [chemical binding]; other site
1415784010347	Q-loop/lid; other site
1415784010348	ABC transporter signature motif; other site
1415784010349	Walker B; other site
1415784010350	D-loop; other site
1415784010351	H-loop/switch region; other site
1415784010352	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1415784010353	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
1415784010354	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1415784010355	Walker A/P-loop; other site
1415784010356	ATP binding site [chemical binding]; other site
1415784010357	Q-loop/lid; other site
1415784010358	ABC transporter signature motif; other site
1415784010359	Walker B; other site
1415784010360	D-loop; other site
1415784010361	H-loop/switch region; other site
1415784010362	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1415784010363	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1415784010364	substrate binding pocket [chemical binding]; other site
1415784010365	membrane-bound complex binding site; other site
1415784010366	hinge residues; other site
1415784010367	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784010368	dimer interface [polypeptide binding]; other site
1415784010369	conserved gate region; other site
1415784010370	putative PBP binding loops; other site
1415784010371	ABC-ATPase subunit interface; other site
1415784010372	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1415784010373	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1415784010374	Walker A/P-loop; other site
1415784010375	ATP binding site [chemical binding]; other site
1415784010376	Q-loop/lid; other site
1415784010377	ABC transporter signature motif; other site
1415784010378	Walker B; other site
1415784010379	D-loop; other site
1415784010380	H-loop/switch region; other site
1415784010381	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
1415784010382	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
1415784010383	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
1415784010384	Protein of unknown function (DUF445); Region: DUF445; pfam04286
1415784010385	hypothetical protein; Provisional; Region: PRK13676
1415784010386	acetolactate synthase; Reviewed; Region: PRK08617
1415784010387	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1415784010388	PYR/PP interface [polypeptide binding]; other site
1415784010389	dimer interface [polypeptide binding]; other site
1415784010390	TPP binding site [chemical binding]; other site
1415784010391	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1415784010392	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1415784010393	TPP-binding site [chemical binding]; other site
1415784010394	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
1415784010395	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
1415784010396	active site
1415784010397	DNA binding site [nucleotide binding]
1415784010398	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1415784010399	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1415784010400	active site
1415784010401	motif I; other site
1415784010402	motif II; other site
1415784010403	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1415784010404	choice-of-anchor A domain; Region: choice_anch_A; TIGR04215
1415784010405	Cna protein B-type domain; Region: Cna_B; pfam05738
1415784010406	Cna protein B-type domain; Region: Cna_B; pfam05738
1415784010407	Cna protein B-type domain; Region: Cna_B; pfam05738
1415784010408	Cna protein B-type domain; Region: Cna_B; pfam05738
1415784010409	Cna protein B-type domain; Region: Cna_B; pfam05738
1415784010410	Cna protein B-type domain; Region: Cna_B; pfam05738
1415784010411	Cna protein B-type domain; Region: Cna_B; pfam05738
1415784010412	Cna protein B-type domain; Region: Cna_B; pfam05738
1415784010413	Cna protein B-type domain; Region: Cna_B; pfam05738
1415784010414	coproporphyrinogen III oxidase; Provisional; Region: PRK08207
1415784010415	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
1415784010416	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1415784010417	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
1415784010418	acyl-activating enzyme (AAE) consensus motif; other site
1415784010419	acyl-activating enzyme (AAE) consensus motif; other site
1415784010420	putative AMP binding site [chemical binding]; other site
1415784010421	putative active site [active]
1415784010422	putative CoA binding site [chemical binding]; other site
1415784010423	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1415784010424	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1415784010425	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1415784010426	enoyl-CoA hydratase; Provisional; Region: PRK07659
1415784010427	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1415784010428	substrate binding site [chemical binding]; other site
1415784010429	oxyanion hole (OAH) forming residues; other site
1415784010430	trimer interface [polypeptide binding]; other site
1415784010431	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532
1415784010432	metal binding site [ion binding]; metal-binding site
1415784010433	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1415784010434	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
1415784010435	putative oligomer interface [polypeptide binding]; other site
1415784010436	putative active site [active]
1415784010437	metal binding site [ion binding]; metal-binding site
1415784010438	Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041
1415784010439	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784010440	S-adenosylmethionine binding site [chemical binding]; other site
1415784010441	Protein of unknown function (DUF2639); Region: DUF2639; pfam11121
1415784010442	Domain of unknown function (DUF3870); Region: DUF3870; pfam12986
1415784010443	carbon starvation induced protein; Validated; Region: PRK02963
1415784010444	substrate binding pocket [chemical binding]; other site
1415784010445	active site
1415784010446	iron coordination sites [ion binding]; other site
1415784010447	Predicted dehydrogenase [General function prediction only]; Region: COG0579
1415784010448	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1415784010449	proline racemase; Provisional; Region: PRK13969
1415784010450	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
1415784010451	ornithine cyclodeaminase; Validated; Region: PRK08618
1415784010452	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1415784010453	NAD(P) binding site [chemical binding]; other site
1415784010454	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1415784010455	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
1415784010456	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1415784010457	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784010458	dimer interface [polypeptide binding]; other site
1415784010459	conserved gate region; other site
1415784010460	putative PBP binding loops; other site
1415784010461	ABC-ATPase subunit interface; other site
1415784010462	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1415784010463	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1415784010464	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784010465	dimer interface [polypeptide binding]; other site
1415784010466	conserved gate region; other site
1415784010467	putative PBP binding loops; other site
1415784010468	ABC-ATPase subunit interface; other site
1415784010469	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1415784010470	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1415784010471	Walker A/P-loop; other site
1415784010472	ATP binding site [chemical binding]; other site
1415784010473	Q-loop/lid; other site
1415784010474	ABC transporter signature motif; other site
1415784010475	Walker B; other site
1415784010476	D-loop; other site
1415784010477	H-loop/switch region; other site
1415784010478	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1415784010479	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
1415784010480	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1415784010481	Walker A/P-loop; other site
1415784010482	ATP binding site [chemical binding]; other site
1415784010483	Q-loop/lid; other site
1415784010484	ABC transporter signature motif; other site
1415784010485	Walker B; other site
1415784010486	D-loop; other site
1415784010487	H-loop/switch region; other site
1415784010488	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1415784010489	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
1415784010490	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
1415784010491	type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197
1415784010492	Protein of unknown function (DUF3958); Region: DUF3958; pfam13125
1415784010493	LXG domain of WXG superfamily; Region: LXG; pfam04740
1415784010494	Domain of unknown function (DUF4176); Region: DUF4176; pfam13780
1415784010495	Domain of unknown function (DUF4176); Region: DUF4176; pfam13780
1415784010496	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
1415784010497	type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197
1415784010498	Protein of unknown function (DUF3958); Region: DUF3958; pfam13125
1415784010499	LXG domain of WXG superfamily; Region: LXG; pfam04740
1415784010500	Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436
1415784010501	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
1415784010502	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
1415784010503	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784010504	putative substrate translocation pore; other site
1415784010505	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1415784010506	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1415784010507	putative active site [active]
1415784010508	heme pocket [chemical binding]; other site
1415784010509	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784010510	ATP binding site [chemical binding]; other site
1415784010511	Mg2+ binding site [ion binding]; other site
1415784010512	G-X-G motif; other site
1415784010513	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
1415784010514	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784010515	active site
1415784010516	phosphorylation site [posttranslational modification]
1415784010517	intermolecular recognition site; other site
1415784010518	dimerization interface [polypeptide binding]; other site
1415784010519	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
1415784010520	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281
1415784010521	HTH domain; Region: HTH_11; cl17392
1415784010522	Predicted transcriptional regulator [Transcription]; Region: COG2378
1415784010523	WYL domain; Region: WYL; pfam13280
1415784010524	Domain of unknown function (DUF3578); Region: DUF3578; pfam12102
1415784010525	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1415784010526	Domain of unknown function (DUF2357); Region: DUF2357; pfam09823
1415784010527	Protein of unknown function (DUF524); Region: DUF524; pfam04411
1415784010528	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281
1415784010529	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1415784010530	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
1415784010531	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1415784010532	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1415784010533	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1415784010534	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1415784010535	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
1415784010536	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1415784010537	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1415784010538	ATP binding site [chemical binding]; other site
1415784010539	putative Mg++ binding site [ion binding]; other site
1415784010540	Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253
1415784010541	Domain of unknown function (DUF1837); Region: DUF1837; pfam08878
1415784010542	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1415784010543	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1415784010544	ATP binding site [chemical binding]; other site
1415784010545	putative Mg++ binding site [ion binding]; other site
1415784010546	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1415784010547	nucleotide binding region [chemical binding]; other site
1415784010548	ATP-binding site [chemical binding]; other site
1415784010549	Helix-turn-helix domain; Region: HTH_36; pfam13730
1415784010550	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1415784010551	replicative DNA helicase; Provisional; Region: PRK06749
1415784010552	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1415784010553	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1415784010554	Walker A motif; other site
1415784010555	ATP binding site [chemical binding]; other site
1415784010556	Walker B motif; other site
1415784010557	DNA binding loops [nucleotide binding]
1415784010558	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
1415784010559	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
1415784010560	NAD(P) binding site [chemical binding]; other site
1415784010561	catalytic residues [active]
1415784010562	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1415784010563	EamA-like transporter family; Region: EamA; pfam00892
1415784010564	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1415784010565	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1415784010566	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1415784010567	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784010568	putative substrate translocation pore; other site
1415784010569	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
1415784010570	catalytic site [active]
1415784010571	Predicted permease; Region: DUF318; cl17795
1415784010572	Predicted permease; Region: DUF318; cl17795
1415784010573	Predicted transcriptional regulators [Transcription]; Region: COG1695
1415784010574	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1415784010575	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
1415784010576	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1415784010577	amidase catalytic site [active]
1415784010578	Zn binding residues [ion binding]; other site
1415784010579	substrate binding site [chemical binding]; other site
1415784010580	Bacterial SH3 domain; Region: SH3_3; pfam08239
1415784010581	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
1415784010582	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
1415784010583	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
1415784010584	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1415784010585	Domain of unknown function (DUF4259); Region: DUF4259; pfam14078
1415784010586	transcriptional antiterminator BglG; Provisional; Region: PRK09772
1415784010587	CAT RNA binding domain; Region: CAT_RBD; smart01061
1415784010588	PRD domain; Region: PRD; pfam00874
1415784010589	PRD domain; Region: PRD; pfam00874
1415784010590	PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824
1415784010591	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1415784010592	active site turn [active]
1415784010593	phosphorylation site [posttranslational modification]
1415784010594	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1415784010595	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1415784010596	HPr interaction site; other site
1415784010597	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1415784010598	active site
1415784010599	phosphorylation site [posttranslational modification]
1415784010600	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
1415784010601	beta-galactosidase; Region: BGL; TIGR03356
1415784010602	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1415784010603	MarR family; Region: MarR_2; pfam12802
1415784010604	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
1415784010605	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
1415784010606	ATP synthase I chain; Region: ATP_synt_I; pfam03899
1415784010607	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1415784010608	non-specific DNA binding site [nucleotide binding]; other site
1415784010609	salt bridge; other site
1415784010610	sequence-specific DNA binding site [nucleotide binding]; other site
1415784010611	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1415784010612	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1415784010613	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784010614	putative substrate translocation pore; other site
1415784010615	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1415784010616	putative DNA binding site [nucleotide binding]; other site
1415784010617	dimerization interface [polypeptide binding]; other site
1415784010618	putative Zn2+ binding site [ion binding]; other site
1415784010619	VanZ like family; Region: VanZ; pfam04892
1415784010620	DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483
1415784010621	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
1415784010622	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
1415784010623	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1415784010624	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
1415784010625	dihydroxyacetone kinase; Provisional; Region: PRK14479
1415784010626	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
1415784010627	DAK2 domain; Region: Dak2; pfam02734
1415784010628	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1415784010629	Predicted transcriptional regulator [Transcription]; Region: COG1959
1415784010630	Transcriptional regulator; Region: Rrf2; pfam02082
1415784010631	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1415784010632	Malarial early transcribed membrane protein (ETRAMP); Region: ETRAMP; cl09917
1415784010633	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1415784010634	Protein of unknown function (DUF3373); Region: DUF3373; pfam11853
1415784010635	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1415784010636	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784010637	active site
1415784010638	phosphorylation site [posttranslational modification]
1415784010639	intermolecular recognition site; other site
1415784010640	dimerization interface [polypeptide binding]; other site
1415784010641	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1415784010642	DNA binding site [nucleotide binding]
1415784010643	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1415784010644	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1415784010645	dimerization interface [polypeptide binding]; other site
1415784010646	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1415784010647	dimer interface [polypeptide binding]; other site
1415784010648	phosphorylation site [posttranslational modification]
1415784010649	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784010650	ATP binding site [chemical binding]; other site
1415784010651	G-X-G motif; other site
1415784010652	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1415784010653	TPR motif; other site
1415784010654	binding surface
1415784010655	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
1415784010656	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
1415784010657	Heat induced stress protein YflT; Region: YflT; pfam11181
1415784010658	Predicted membrane protein [Function unknown]; Region: COG2261
1415784010659	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1415784010660	anti sigma factor interaction site; other site
1415784010661	regulatory phosphorylation site [posttranslational modification]; other site
1415784010662	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
1415784010663	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784010664	ATP binding site [chemical binding]; other site
1415784010665	Mg2+ binding site [ion binding]; other site
1415784010666	G-X-G motif; other site
1415784010667	RNA polymerase sigma-B factor; Region: Sigma_B; TIGR02941
1415784010668	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1415784010669	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1415784010670	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1415784010671	DNA binding residues [nucleotide binding]
1415784010672	Ferritin-like domain; Region: Ferritin; pfam00210
1415784010673	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
1415784010674	dinuclear metal binding motif [ion binding]; other site
1415784010675	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1415784010676	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784010677	active site
1415784010678	phosphorylation site [posttranslational modification]
1415784010679	intermolecular recognition site; other site
1415784010680	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
1415784010681	dimerization interface [polypeptide binding]; other site
1415784010682	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1415784010683	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1415784010684	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
1415784010685	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
1415784010686	CHASE3 domain; Region: CHASE3; pfam05227
1415784010687	GAF domain; Region: GAF; pfam01590
1415784010688	GAF domain; Region: GAF_2; pfam13185
1415784010689	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1415784010690	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1415784010691	dimer interface [polypeptide binding]; other site
1415784010692	phosphorylation site [posttranslational modification]
1415784010693	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784010694	ATP binding site [chemical binding]; other site
1415784010695	Mg2+ binding site [ion binding]; other site
1415784010696	G-X-G motif; other site
1415784010697	Response regulator receiver domain; Region: Response_reg; pfam00072
1415784010698	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784010699	active site
1415784010700	phosphorylation site [posttranslational modification]
1415784010701	intermolecular recognition site; other site
1415784010702	dimerization interface [polypeptide binding]; other site
1415784010703	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206
1415784010704	Protein of unknown function (DUF4028); Region: DUF4028; pfam13220
1415784010705	hypothetical protein; Provisional; Region: PRK12856
1415784010706	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
1415784010707	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784010708	putative substrate translocation pore; other site
1415784010709	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1415784010710	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1415784010711	DNA-binding site [nucleotide binding]; DNA binding site
1415784010712	FCD domain; Region: FCD; pfam07729
1415784010713	2-enoyl thioester reductase-like; Region: ETR_like; cd05282
1415784010714	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1415784010715	NADP binding site [chemical binding]; other site
1415784010716	dimer interface [polypeptide binding]; other site
1415784010717	YhzD-like protein; Region: YhzD; pfam14120
1415784010718	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1415784010719	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1415784010720	active site
1415784010721	metal binding site [ion binding]; metal-binding site
1415784010722	DNA binding site [nucleotide binding]
1415784010723	AAA domain; Region: AAA_27; pfam13514
1415784010724	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
1415784010725	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
1415784010726	generic binding surface II; other site
1415784010727	generic binding surface I; other site
1415784010728	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1415784010729	Zn2+ binding site [ion binding]; other site
1415784010730	Mg2+ binding site [ion binding]; other site
1415784010731	MoxR-like ATPases [General function prediction only]; Region: COG0714
1415784010732	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1415784010733	Zn binding site [ion binding]; other site
1415784010734	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1415784010735	Zn binding site [ion binding]; other site
1415784010736	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1415784010737	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1415784010738	Zn binding site [ion binding]; other site
1415784010739	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1415784010740	Zn binding site [ion binding]; other site
1415784010741	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1415784010742	binding surface
1415784010743	TPR motif; other site
1415784010744	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1415784010745	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1415784010746	TPR motif; other site
1415784010747	binding surface
1415784010748	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1415784010749	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1415784010750	Sporulation protein YhaL; Region: Spore_YhaL; pfam14147
1415784010751	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1415784010752	non-specific DNA binding site [nucleotide binding]; other site
1415784010753	salt bridge; other site
1415784010754	sequence-specific DNA binding site [nucleotide binding]; other site
1415784010755	Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954
1415784010756	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
1415784010757	amphipathic channel; other site
1415784010758	Asn-Pro-Ala signature motifs; other site
1415784010759	glycerol kinase; Provisional; Region: glpK; PRK00047
1415784010760	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1415784010761	N- and C-terminal domain interface [polypeptide binding]; other site
1415784010762	active site
1415784010763	MgATP binding site [chemical binding]; other site
1415784010764	catalytic site [active]
1415784010765	metal binding site [ion binding]; metal-binding site
1415784010766	glycerol binding site [chemical binding]; other site
1415784010767	homotetramer interface [polypeptide binding]; other site
1415784010768	homodimer interface [polypeptide binding]; other site
1415784010769	FBP binding site [chemical binding]; other site
1415784010770	protein IIAGlc interface [polypeptide binding]; other site
1415784010771	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1415784010772	RNA polymerase factor sigma C; Reviewed; Region: PRK09415
1415784010773	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1415784010774	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1415784010775	DNA binding residues [nucleotide binding]
1415784010776	lineage-specific thermal regulator protein; Provisional; Region: lstR; PRK09416
1415784010777	Predicted transcriptional regulators [Transcription]; Region: COG1695
1415784010778	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
1415784010779	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
1415784010780	Part of AAA domain; Region: AAA_19; pfam13245
1415784010781	Family description; Region: UvrD_C_2; pfam13538
1415784010782	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095
1415784010783	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1415784010784	Protein of unknown function (DUF1878); Region: DUF1878; pfam08963
1415784010785	transcriptional regulator Hpr; Provisional; Region: PRK13777
1415784010786	MarR family; Region: MarR; pfam01047
1415784010787	YtxH-like protein; Region: YtxH; cl02079
1415784010788	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
1415784010789	HIT family signature motif; other site
1415784010790	catalytic residue [active]
1415784010791	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1415784010792	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1415784010793	Walker A/P-loop; other site
1415784010794	ATP binding site [chemical binding]; other site
1415784010795	Q-loop/lid; other site
1415784010796	ABC transporter signature motif; other site
1415784010797	Walker B; other site
1415784010798	D-loop; other site
1415784010799	H-loop/switch region; other site
1415784010800	Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975
1415784010801	EcsC protein family; Region: EcsC; pfam12787
1415784010802	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1415784010803	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1415784010804	Uncharacterized conserved protein [Function unknown]; Region: COG3402
1415784010805	Predicted membrane protein [Function unknown]; Region: COG3428
1415784010806	Bacterial PH domain; Region: DUF304; pfam03703
1415784010807	Bacterial PH domain; Region: DUF304; pfam03703
1415784010808	Protein of unknown function (DUF975); Region: DUF975; pfam06161
1415784010809	Domain of unknown function (DUF4363); Region: DUF4363; pfam14276
1415784010810	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1415784010811	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1415784010812	Chloramphenicol acetyltransferase; Region: CAT; cl02008
1415784010813	Uncharacterized conserved protein [Function unknown]; Region: COG3402
1415784010814	Bacterial PH domain; Region: DUF304; pfam03703
1415784010815	Bacterial PH domain; Region: DUF304; pfam03703
1415784010816	Bacterial PH domain; Region: DUF304; pfam03703
1415784010817	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1415784010818	Transglycosylase; Region: Transgly; pfam00912
1415784010819	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1415784010820	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1415784010821	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
1415784010822	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1415784010823	substrate binding site [chemical binding]; other site
1415784010824	active site
1415784010825	ferrochelatase; Provisional; Region: PRK12435
1415784010826	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1415784010827	C-terminal domain interface [polypeptide binding]; other site
1415784010828	active site
1415784010829	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1415784010830	active site
1415784010831	N-terminal domain interface [polypeptide binding]; other site
1415784010832	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
1415784010833	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1415784010834	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1415784010835	Fn3 associated; Region: Fn3_assoc; pfam13287
1415784010836	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
1415784010837	generic binding surface II; other site
1415784010838	generic binding surface I; other site
1415784010839	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
1415784010840	putative active site [active]
1415784010841	putative catalytic site [active]
1415784010842	putative Mg binding site IVb [ion binding]; other site
1415784010843	putative phosphate binding site [ion binding]; other site
1415784010844	putative DNA binding site [nucleotide binding]; other site
1415784010845	putative Mg binding site IVa [ion binding]; other site
1415784010846	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1415784010847	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1415784010848	Predicted membrane protein [Function unknown]; Region: COG1511
1415784010849	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1415784010850	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
1415784010851	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1415784010852	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589
1415784010853	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
1415784010854	DinB superfamily; Region: DinB_2; pfam12867
1415784010855	Protein of unknown function (DUF1569); Region: DUF1569; pfam07606
1415784010856	Predicted transcriptional regulator [Transcription]; Region: COG2378
1415784010857	HTH domain; Region: HTH_11; pfam08279
1415784010858	WYL domain; Region: WYL; pfam13280
1415784010859	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1415784010860	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1415784010861	DNA binding site [nucleotide binding]
1415784010862	domain linker motif; other site
1415784010863	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
1415784010864	putative dimerization interface [polypeptide binding]; other site
1415784010865	putative ligand binding site [chemical binding]; other site
1415784010866	YhfH-like protein; Region: YhfH; pfam14149
1415784010867	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
1415784010868	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1415784010869	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
1415784010870	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
1415784010871	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
1415784010872	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1415784010873	acyl-activating enzyme (AAE) consensus motif; other site
1415784010874	putative AMP binding site [chemical binding]; other site
1415784010875	putative active site [active]
1415784010876	putative CoA binding site [chemical binding]; other site
1415784010877	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1415784010878	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1415784010879	putative active site [active]
1415784010880	putative metal binding site [ion binding]; other site
1415784010881	CAAX protease self-immunity; Region: Abi; pfam02517
1415784010882	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
1415784010883	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1415784010884	Zn2+ binding site [ion binding]; other site
1415784010885	Mg2+ binding site [ion binding]; other site
1415784010886	Putative zinc-finger; Region: zf-HC2; pfam13490
1415784010887	Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800
1415784010888	Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791
1415784010889	RNA polymerase sigma factor; Provisional; Region: PRK12541
1415784010890	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1415784010891	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1415784010892	DNA binding residues [nucleotide binding]
1415784010893	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1415784010894	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1415784010895	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1415784010896	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
1415784010897	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1415784010898	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1415784010899	active site
1415784010900	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1415784010901	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1415784010902	dimer interface [polypeptide binding]; other site
1415784010903	phosphorylation site [posttranslational modification]
1415784010904	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784010905	ATP binding site [chemical binding]; other site
1415784010906	Mg2+ binding site [ion binding]; other site
1415784010907	G-X-G motif; other site
1415784010908	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1415784010909	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784010910	active site
1415784010911	phosphorylation site [posttranslational modification]
1415784010912	intermolecular recognition site; other site
1415784010913	dimerization interface [polypeptide binding]; other site
1415784010914	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1415784010915	DNA binding site [nucleotide binding]
1415784010916	CAAX protease self-immunity; Region: Abi; pfam02517
1415784010917	Peptidase family M48; Region: Peptidase_M48; pfam01435
1415784010918	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1415784010919	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1415784010920	dimerization interface [polypeptide binding]; other site
1415784010921	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1415784010922	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1415784010923	dimer interface [polypeptide binding]; other site
1415784010924	putative CheW interface [polypeptide binding]; other site
1415784010925	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1415784010926	EamA-like transporter family; Region: EamA; pfam00892
1415784010927	EamA-like transporter family; Region: EamA; pfam00892
1415784010928	malate synthase A; Region: malate_syn_A; TIGR01344
1415784010929	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
1415784010930	active site
1415784010931	isocitrate lyase; Provisional; Region: PRK15063
1415784010932	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1415784010933	tetramer interface [polypeptide binding]; other site
1415784010934	active site
1415784010935	Mg2+/Mn2+ binding site [ion binding]; other site
1415784010936	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1415784010937	Phosphotransferase enzyme family; Region: APH; pfam01636
1415784010938	active site
1415784010939	substrate binding site [chemical binding]; other site
1415784010940	ATP binding site [chemical binding]; other site
1415784010941	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1415784010942	DNA-binding site [nucleotide binding]; DNA binding site
1415784010943	RNA-binding motif; other site
1415784010944	ComK protein; Region: ComK; pfam06338
1415784010945	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1415784010946	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1415784010947	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1415784010948	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1415784010949	Catalytic site [active]
1415784010950	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
1415784010951	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
1415784010952	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1415784010953	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
1415784010954	Part of AAA domain; Region: AAA_19; pfam13245
1415784010955	Family description; Region: UvrD_C_2; pfam13538
1415784010956	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1415784010957	hypothetical protein; Provisional; Region: PRK07758
1415784010958	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
1415784010959	Protein of unknown function (DUF2772); Region: DUF2772; pfam10970
1415784010960	Spore germination protein GerPC; Region: GerPC; pfam10737
1415784010961	Protein of unknown function (DUF2539); Region: DUF2539; pfam10803
1415784010962	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
1415784010963	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
1415784010964	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
1415784010965	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1415784010966	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
1415784010967	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1415784010968	inhibitor-cofactor binding pocket; inhibition site
1415784010969	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784010970	catalytic residue [active]
1415784010971	hypothetical protein; Provisional; Region: PRK13673
1415784010972	Protein of unknown function (DUF2777); Region: DUF2777; pfam10949
1415784010973	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1415784010974	active site
1415784010975	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
1415784010976	dimer interface [polypeptide binding]; other site
1415784010977	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1415784010978	Ligand Binding Site [chemical binding]; other site
1415784010979	Molecular Tunnel; other site
1415784010980	ferrochelatase; Provisional; Region: PRK12435
1415784010981	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1415784010982	C-terminal domain interface [polypeptide binding]; other site
1415784010983	active site
1415784010984	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1415784010985	active site
1415784010986	N-terminal domain interface [polypeptide binding]; other site
1415784010987	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1415784010988	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
1415784010989	tetramer interface [polypeptide binding]; other site
1415784010990	heme binding pocket [chemical binding]; other site
1415784010991	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1415784010992	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
1415784010993	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1415784010994	active site
1415784010995	catalytic site [active]
1415784010996	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
1415784010997	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
1415784010998	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
1415784010999	S1 domain; Region: S1_2; pfam13509
1415784011000	RHS Repeat; Region: RHS_repeat; pfam05593
1415784011001	RHS protein; Region: RHS; pfam03527
1415784011002	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002
1415784011003	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1415784011004	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1415784011005	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1415784011006	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1415784011007	Protein of unknown function (DUF3813); Region: DUF3813; pfam12758
1415784011008	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1415784011009	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1415784011010	active site
1415784011011	motif I; other site
1415784011012	motif II; other site
1415784011013	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1415784011014	YjzC-like protein; Region: YjzC; pfam14168
1415784011015	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1415784011016	Clp amino terminal domain; Region: Clp_N; pfam02861
1415784011017	Clp amino terminal domain; Region: Clp_N; pfam02861
1415784011018	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1415784011019	Walker A motif; other site
1415784011020	ATP binding site [chemical binding]; other site
1415784011021	Walker B motif; other site
1415784011022	arginine finger; other site
1415784011023	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1415784011024	Walker A motif; other site
1415784011025	ATP binding site [chemical binding]; other site
1415784011026	Walker B motif; other site
1415784011027	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1415784011028	Protein of unknown function (DUF2929); Region: DUF2929; pfam11151
1415784011029	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1415784011030	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1415784011031	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1415784011032	NAD(P) binding site [chemical binding]; other site
1415784011033	active site
1415784011034	ComZ; Region: ComZ; pfam10815
1415784011035	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1415784011036	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1415784011037	dimer interface [polypeptide binding]; other site
1415784011038	active site
1415784011039	CoA binding pocket [chemical binding]; other site
1415784011040	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
1415784011041	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1415784011042	dimer interface [polypeptide binding]; other site
1415784011043	active site
1415784011044	Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026
1415784011045	Protein of unknown function (DUF3603); Region: DUF3603; pfam12227
1415784011046	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1415784011047	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1415784011048	active site
1415784011049	HIGH motif; other site
1415784011050	dimer interface [polypeptide binding]; other site
1415784011051	KMSKS motif; other site
1415784011052	Domain of unknown function (DUF3899); Region: DUF3899; pfam13038
1415784011053	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1415784011054	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1415784011055	peptide binding site [polypeptide binding]; other site
1415784011056	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1415784011057	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784011058	dimer interface [polypeptide binding]; other site
1415784011059	conserved gate region; other site
1415784011060	putative PBP binding loops; other site
1415784011061	ABC-ATPase subunit interface; other site
1415784011062	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1415784011063	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
1415784011064	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784011065	dimer interface [polypeptide binding]; other site
1415784011066	conserved gate region; other site
1415784011067	putative PBP binding loops; other site
1415784011068	ABC-ATPase subunit interface; other site
1415784011069	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1415784011070	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1415784011071	Walker A/P-loop; other site
1415784011072	ATP binding site [chemical binding]; other site
1415784011073	Q-loop/lid; other site
1415784011074	ABC transporter signature motif; other site
1415784011075	Walker B; other site
1415784011076	D-loop; other site
1415784011077	H-loop/switch region; other site
1415784011078	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1415784011079	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1415784011080	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1415784011081	Walker A/P-loop; other site
1415784011082	ATP binding site [chemical binding]; other site
1415784011083	Q-loop/lid; other site
1415784011084	ABC transporter signature motif; other site
1415784011085	Walker B; other site
1415784011086	D-loop; other site
1415784011087	H-loop/switch region; other site
1415784011088	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1415784011089	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1415784011090	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
1415784011091	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1415784011092	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1415784011093	peptide binding site [polypeptide binding]; other site
1415784011094	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
1415784011095	ArsC family; Region: ArsC; pfam03960
1415784011096	putative catalytic residues [active]
1415784011097	thiol/disulfide switch; other site
1415784011098	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
1415784011099	adaptor protein; Provisional; Region: PRK02315
1415784011100	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
1415784011101	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1415784011102	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1415784011103	putative active site [active]
1415784011104	catalytic site [active]
1415784011105	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1415784011106	putative active site [active]
1415784011107	catalytic site [active]
1415784011108	Competence protein CoiA-like family; Region: CoiA; cl11541
1415784011109	oligoendopeptidase F; Region: pepF; TIGR00181
1415784011110	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
1415784011111	active site
1415784011112	Zn binding site [ion binding]; other site
1415784011113	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
1415784011114	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
1415784011115	catalytic residues [active]
1415784011116	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
1415784011117	apolar tunnel; other site
1415784011118	heme binding site [chemical binding]; other site
1415784011119	dimerization interface [polypeptide binding]; other site
1415784011120	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
1415784011121	putative active site [active]
1415784011122	putative metal binding residues [ion binding]; other site
1415784011123	signature motif; other site
1415784011124	putative triphosphate binding site [ion binding]; other site
1415784011125	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1415784011126	synthetase active site [active]
1415784011127	NTP binding site [chemical binding]; other site
1415784011128	metal binding site [ion binding]; metal-binding site
1415784011129	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
1415784011130	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1415784011131	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1415784011132	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1415784011133	active site
1415784011134	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
1415784011135	trimer interface [polypeptide binding]; other site
1415784011136	Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962
1415784011137	bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625
1415784011138	Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423
1415784011139	active site
1415784011140	metal binding site [ion binding]; metal-binding site
1415784011141	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
1415784011142	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1415784011143	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1415784011144	active site
1415784011145	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1415784011146	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784011147	S-adenosylmethionine binding site [chemical binding]; other site
1415784011148	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1415784011149	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
1415784011150	putative metal binding site; other site
1415784011151	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1415784011152	binding surface
1415784011153	TPR motif; other site
1415784011154	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1415784011155	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784011156	S-adenosylmethionine binding site [chemical binding]; other site
1415784011157	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1415784011158	catalytic residues [active]
1415784011159	Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712
1415784011160	Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712
1415784011161	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1415784011162	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1415784011163	active site
1415784011164	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
1415784011165	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1415784011166	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1415784011167	NAD binding site [chemical binding]; other site
1415784011168	substrate binding site [chemical binding]; other site
1415784011169	homodimer interface [polypeptide binding]; other site
1415784011170	active site
1415784011171	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1415784011172	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
1415784011173	NADP binding site [chemical binding]; other site
1415784011174	active site
1415784011175	putative substrate binding site [chemical binding]; other site
1415784011176	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594
1415784011177	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1415784011178	NAD binding site [chemical binding]; other site
1415784011179	homotetramer interface [polypeptide binding]; other site
1415784011180	homodimer interface [polypeptide binding]; other site
1415784011181	substrate binding site [chemical binding]; other site
1415784011182	active site
1415784011183	Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153
1415784011184	Protein of unknown function (DUF1360); Region: DUF1360; pfam07098
1415784011185	Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612
1415784011186	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1415784011187	Part of AAA domain; Region: AAA_19; pfam13245
1415784011188	Family description; Region: UvrD_C_2; pfam13538
1415784011189	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1415784011190	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784011191	Coenzyme A binding pocket [chemical binding]; other site
1415784011192	hypothetical protein; Provisional; Region: PRK13679
1415784011193	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1415784011194	Putative esterase; Region: Esterase; pfam00756
1415784011195	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1415784011196	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1415784011197	EamA-like transporter family; Region: EamA; pfam00892
1415784011198	EamA-like transporter family; Region: EamA; pfam00892
1415784011199	Domain of unknown function (DUF1200); Region: DUF1200; pfam06713
1415784011200	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
1415784011201	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
1415784011202	Na binding site [ion binding]; other site
1415784011203	anthranilate synthase component I; Provisional; Region: PRK13570
1415784011204	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1415784011205	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1415784011206	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
1415784011207	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1415784011208	glutamine binding [chemical binding]; other site
1415784011209	catalytic triad [active]
1415784011210	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1415784011211	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1415784011212	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1415784011213	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1415784011214	active site
1415784011215	ribulose/triose binding site [chemical binding]; other site
1415784011216	phosphate binding site [ion binding]; other site
1415784011217	substrate (anthranilate) binding pocket [chemical binding]; other site
1415784011218	product (indole) binding pocket [chemical binding]; other site
1415784011219	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1415784011220	active site
1415784011221	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1415784011222	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1415784011223	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784011224	catalytic residue [active]
1415784011225	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
1415784011226	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1415784011227	substrate binding site [chemical binding]; other site
1415784011228	active site
1415784011229	catalytic residues [active]
1415784011230	heterodimer interface [polypeptide binding]; other site
1415784011231	Protein of unknown function (DUF4029); Region: DUF4029; pfam13221
1415784011232	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
1415784011233	L-lactate permease; Region: Lactate_perm; cl00701
1415784011234	Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042
1415784011235	RHS protein; Region: RHS; pfam03527
1415784011236	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
1415784011237	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
1415784011238	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1415784011239	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
1415784011240	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
1415784011241	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
1415784011242	Double zinc ribbon; Region: DZR; pfam12773
1415784011243	Predicted membrane protein [Function unknown]; Region: COG4640
1415784011244	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
1415784011245	YARHG domain; Region: YARHG; pfam13308
1415784011246	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
1415784011247	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1415784011248	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1415784011249	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1415784011250	Predicted acetyltransferase [General function prediction only]; Region: COG5628
1415784011251	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784011252	Coenzyme A binding pocket [chemical binding]; other site
1415784011253	Protein of unknown function (DUF3908); Region: DUF3908; pfam13048
1415784011254	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784011255	S-adenosylmethionine binding site [chemical binding]; other site
1415784011256	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
1415784011257	NADPH bind site [chemical binding]; other site
1415784011258	putative FMN binding site [chemical binding]; other site
1415784011259	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
1415784011260	putative FMN binding site [chemical binding]; other site
1415784011261	NADPH bind site [chemical binding]; other site
1415784011262	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
1415784011263	YcaO-like family; Region: YcaO; pfam02624
1415784011264	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
1415784011265	putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693
1415784011266	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
1415784011267	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
1415784011268	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1415784011269	E3 interaction surface; other site
1415784011270	lipoyl attachment site [posttranslational modification]; other site
1415784011271	e3 binding domain; Region: E3_binding; pfam02817
1415784011272	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1415784011273	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
1415784011274	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
1415784011275	TPP-binding site [chemical binding]; other site
1415784011276	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1415784011277	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
1415784011278	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1415784011279	salt bridge; other site
1415784011280	non-specific DNA binding site [nucleotide binding]; other site
1415784011281	sequence-specific DNA binding site [nucleotide binding]; other site
1415784011282	Domain of unknown function (DUF3976); Region: DUF3976; pfam13121
1415784011283	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
1415784011284	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1415784011285	Walker A/P-loop; other site
1415784011286	ATP binding site [chemical binding]; other site
1415784011287	Q-loop/lid; other site
1415784011288	ABC transporter signature motif; other site
1415784011289	Walker B; other site
1415784011290	D-loop; other site
1415784011291	H-loop/switch region; other site
1415784011292	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
1415784011293	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
1415784011294	Helix-turn-helix domain; Region: HTH_17; cl17695
1415784011295	cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104
1415784011296	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1415784011297	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1415784011298	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
1415784011299	Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681
1415784011300	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1415784011301	Catalytic site [active]
1415784011302	Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780
1415784011303	Domain of unknown function (DUF4047); Region: DUF4047; pfam13256
1415784011304	Camelysin metallo-endopeptidase; Region: Peptidase_M73; pfam12389
1415784011305	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1415784011306	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1415784011307	non-specific DNA binding site [nucleotide binding]; other site
1415784011308	salt bridge; other site
1415784011309	sequence-specific DNA binding site [nucleotide binding]; other site
1415784011310	Anti-repressor SinI; Region: SinI; pfam08671
1415784011311	Anti-repressor SinI; Region: SinI; pfam08671
1415784011312	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412
1415784011313	Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547
1415784011314	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
1415784011315	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
1415784011316	NAD(P) binding site [chemical binding]; other site
1415784011317	catalytic residues [active]
1415784011318	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1415784011319	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
1415784011320	Walker A/P-loop; other site
1415784011321	ATP binding site [chemical binding]; other site
1415784011322	Q-loop/lid; other site
1415784011323	ABC transporter signature motif; other site
1415784011324	Walker B; other site
1415784011325	D-loop; other site
1415784011326	H-loop/switch region; other site
1415784011327	TOBE domain; Region: TOBE_2; pfam08402
1415784011328	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1415784011329	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784011330	dimer interface [polypeptide binding]; other site
1415784011331	conserved gate region; other site
1415784011332	putative PBP binding loops; other site
1415784011333	ABC-ATPase subunit interface; other site
1415784011334	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1415784011335	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784011336	dimer interface [polypeptide binding]; other site
1415784011337	conserved gate region; other site
1415784011338	putative PBP binding loops; other site
1415784011339	ABC-ATPase subunit interface; other site
1415784011340	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1415784011341	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
1415784011342	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1415784011343	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1415784011344	active site
1415784011345	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
1415784011346	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
1415784011347	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1415784011348	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1415784011349	active site
1415784011350	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
1415784011351	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
1415784011352	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1415784011353	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1415784011354	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1415784011355	Cysteine-rich domain; Region: CCG; pfam02754
1415784011356	Cysteine-rich domain; Region: CCG; pfam02754
1415784011357	FAD binding domain; Region: FAD_binding_4; pfam01565
1415784011358	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
1415784011359	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
1415784011360	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
1415784011361	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1415784011362	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
1415784011363	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1415784011364	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1415784011365	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1415784011366	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784011367	active site
1415784011368	phosphorylation site [posttranslational modification]
1415784011369	intermolecular recognition site; other site
1415784011370	dimerization interface [polypeptide binding]; other site
1415784011371	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1415784011372	DNA binding site [nucleotide binding]
1415784011373	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1415784011374	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1415784011375	dimerization interface [polypeptide binding]; other site
1415784011376	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1415784011377	dimer interface [polypeptide binding]; other site
1415784011378	phosphorylation site [posttranslational modification]
1415784011379	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784011380	ATP binding site [chemical binding]; other site
1415784011381	Mg2+ binding site [ion binding]; other site
1415784011382	G-X-G motif; other site
1415784011383	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1415784011384	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1415784011385	DNA-binding site [nucleotide binding]; DNA binding site
1415784011386	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1415784011387	CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288
1415784011388	Cysteine-rich domain; Region: CCG; pfam02754
1415784011389	Cysteine-rich domain; Region: CCG; pfam02754
1415784011390	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
1415784011391	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
1415784011392	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
1415784011393	Uncharacterized conserved protein [Function unknown]; Region: COG1556
1415784011394	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
1415784011395	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
1415784011396	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
1415784011397	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
1415784011398	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
1415784011399	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1415784011400	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1415784011401	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
1415784011402	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
1415784011403	dimer interaction site [polypeptide binding]; other site
1415784011404	substrate-binding tunnel; other site
1415784011405	active site
1415784011406	catalytic site [active]
1415784011407	substrate binding site [chemical binding]; other site
1415784011408	Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820
1415784011409	poly-beta-hydroxybutyrate-responsive repressor; Region: repress_PhaQ; TIGR02719
1415784011410	Predicted transcriptional regulators [Transcription]; Region: COG1695
1415784011411	polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132
1415784011412	acetoacetyl-CoA reductase; Provisional; Region: PRK12935
1415784011413	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1415784011414	NAD(P) binding site [chemical binding]; other site
1415784011415	active site
1415784011416	poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836
1415784011417	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
1415784011418	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
1415784011419	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1415784011420	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1415784011421	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1415784011422	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1415784011423	Protein of unknown function (DUF3905); Region: DUF3905; pfam13045
1415784011424	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1415784011425	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
1415784011426	putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265
1415784011427	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1415784011428	Walker A/P-loop; other site
1415784011429	ATP binding site [chemical binding]; other site
1415784011430	Q-loop/lid; other site
1415784011431	ABC transporter signature motif; other site
1415784011432	Walker B; other site
1415784011433	D-loop; other site
1415784011434	H-loop/switch region; other site
1415784011435	TOBE domain; Region: TOBE_2; pfam08402
1415784011436	putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262
1415784011437	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784011438	dimer interface [polypeptide binding]; other site
1415784011439	conserved gate region; other site
1415784011440	putative PBP binding loops; other site
1415784011441	ABC-ATPase subunit interface; other site
1415784011442	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784011443	dimer interface [polypeptide binding]; other site
1415784011444	conserved gate region; other site
1415784011445	putative PBP binding loops; other site
1415784011446	ABC-ATPase subunit interface; other site
1415784011447	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
1415784011448	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1415784011449	motif II; other site
1415784011450	2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479
1415784011451	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1415784011452	catalytic residue [active]
1415784011453	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
1415784011454	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1415784011455	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1415784011456	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1415784011457	hypothetical protein; Validated; Region: PRK06755
1415784011458	intersubunit interface [polypeptide binding]; other site
1415784011459	active site
1415784011460	Zn2+ binding site [ion binding]; other site
1415784011461	FOG: CBS domain [General function prediction only]; Region: COG0517
1415784011462	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1415784011463	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
1415784011464	NodB motif; other site
1415784011465	putative active site [active]
1415784011466	putative catalytic site [active]
1415784011467	Zn binding site [ion binding]; other site
1415784011468	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
1415784011469	Protein of unknown function (DUF3149); Region: DUF3149; pfam11346
1415784011470	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1415784011471	dimer interface [polypeptide binding]; other site
1415784011472	phosphorylation site [posttranslational modification]
1415784011473	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784011474	ATP binding site [chemical binding]; other site
1415784011475	Mg2+ binding site [ion binding]; other site
1415784011476	G-X-G motif; other site
1415784011477	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1415784011478	MarR family; Region: MarR; pfam01047
1415784011479	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606
1415784011480	oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289
1415784011481	active site
1415784011482	Zn binding site [ion binding]; other site
1415784011483	DinB superfamily; Region: DinB_2; pfam12867
1415784011484	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1415784011485	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1415784011486	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1415784011487	dimer interface [polypeptide binding]; other site
1415784011488	phosphorylation site [posttranslational modification]
1415784011489	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784011490	ATP binding site [chemical binding]; other site
1415784011491	Mg2+ binding site [ion binding]; other site
1415784011492	G-X-G motif; other site
1415784011493	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
1415784011494	Ligand Binding Site [chemical binding]; other site
1415784011495	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
1415784011496	active site
1415784011497	7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365
1415784011498	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1415784011499	FeS/SAM binding site; other site
1415784011500	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
1415784011501	Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; pfam09953
1415784011502	Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406
1415784011503	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784011504	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1415784011505	Coenzyme A binding pocket [chemical binding]; other site
1415784011506	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
1415784011507	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
1415784011508	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
1415784011509	Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867
1415784011510	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1415784011511	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1415784011512	dimer interface [polypeptide binding]; other site
1415784011513	putative radical transfer pathway; other site
1415784011514	diiron center [ion binding]; other site
1415784011515	tyrosyl radical; other site
1415784011516	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1415784011517	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1415784011518	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1415784011519	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
1415784011520	NAD(P) binding site [chemical binding]; other site
1415784011521	Protein of unknown function (DUF3055); Region: DUF3055; pfam11256
1415784011522	hypothetical protein; Validated; Region: PRK06748
1415784011523	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
1415784011524	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1415784011525	putative active site [active]
1415784011526	heme pocket [chemical binding]; other site
1415784011527	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1415784011528	Walker A motif; other site
1415784011529	ATP binding site [chemical binding]; other site
1415784011530	Walker B motif; other site
1415784011531	arginine finger; other site
1415784011532	Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119
1415784011533	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1415784011534	tetramerization interface [polypeptide binding]; other site
1415784011535	NAD(P) binding site [chemical binding]; other site
1415784011536	catalytic residues [active]
1415784011537	putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522
1415784011538	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1415784011539	inhibitor-cofactor binding pocket; inhibition site
1415784011540	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784011541	catalytic residue [active]
1415784011542	Predicted transcriptional regulators [Transcription]; Region: COG1725
1415784011543	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1415784011544	DNA-binding site [nucleotide binding]; DNA binding site
1415784011545	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1415784011546	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1415784011547	Walker A/P-loop; other site
1415784011548	ATP binding site [chemical binding]; other site
1415784011549	Q-loop/lid; other site
1415784011550	ABC transporter signature motif; other site
1415784011551	Walker B; other site
1415784011552	D-loop; other site
1415784011553	H-loop/switch region; other site
1415784011554	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1415784011555	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1415784011556	Walker A/P-loop; other site
1415784011557	ATP binding site [chemical binding]; other site
1415784011558	Q-loop/lid; other site
1415784011559	ABC transporter signature motif; other site
1415784011560	Walker B; other site
1415784011561	D-loop; other site
1415784011562	H-loop/switch region; other site
1415784011563	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
1415784011564	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1415784011565	CAAX protease self-immunity; Region: Abi; pfam02517
1415784011566	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
1415784011567	Protein of unknown function (DUF3913); Region: DUF3913; pfam13052
1415784011568	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1415784011569	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1415784011570	putative DNA binding site [nucleotide binding]; other site
1415784011571	putative Zn2+ binding site [ion binding]; other site
1415784011572	AsnC family; Region: AsnC_trans_reg; pfam01037
1415784011573	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1415784011574	Isochorismatase family; Region: Isochorismatase; pfam00857
1415784011575	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
1415784011576	catalytic triad [active]
1415784011577	conserved cis-peptide bond; other site
1415784011578	SseB protein; Region: SseB; cl06279
1415784011579	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
1415784011580	dimer interface [polypeptide binding]; other site
1415784011581	catalytic triad [active]
1415784011582	Nitronate monooxygenase; Region: NMO; pfam03060
1415784011583	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1415784011584	FMN binding site [chemical binding]; other site
1415784011585	substrate binding site [chemical binding]; other site
1415784011586	putative catalytic residue [active]
1415784011587	D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092
1415784011588	DltD N-terminal region; Region: DltD_N; pfam04915
1415784011589	DltD central region; Region: DltD_M; pfam04918
1415784011590	DltD C-terminal region; Region: DltD_C; pfam04914
1415784011591	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
1415784011592	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
1415784011593	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
1415784011594	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
1415784011595	acyl-activating enzyme (AAE) consensus motif; other site
1415784011596	AMP binding site [chemical binding]; other site
1415784011597	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1415784011598	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
1415784011599	metal binding site [ion binding]; metal-binding site
1415784011600	dimer interface [polypeptide binding]; other site
1415784011601	flavodoxin; Provisional; Region: PRK06756
1415784011602	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
1415784011603	Phosphotransferase enzyme family; Region: APH; pfam01636
1415784011604	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1415784011605	active site
1415784011606	substrate binding site [chemical binding]; other site
1415784011607	ATP binding site [chemical binding]; other site
1415784011608	multidrug efflux protein; Reviewed; Region: PRK01766
1415784011609	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
1415784011610	cation binding site [ion binding]; other site
1415784011611	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1415784011612	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
1415784011613	hydrophobic ligand binding site; other site
1415784011614	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1415784011615	catalytic residues [active]
1415784011616	Regulatory protein YrvL; Region: YrvL; pfam14184
1415784011617	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1415784011618	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1415784011619	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1415784011620	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
1415784011621	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1415784011622	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1415784011623	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
1415784011624	hypothetical protein; Provisional; Region: PRK03094
1415784011625	Protein of unknown function (DUF3911); Region: DUF3911; pfam13050
1415784011626	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1415784011627	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
1415784011628	homodimer interface [polypeptide binding]; other site
1415784011629	substrate-cofactor binding pocket; other site
1415784011630	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784011631	catalytic residue [active]
1415784011632	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710
1415784011633	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1415784011634	PYR/PP interface [polypeptide binding]; other site
1415784011635	dimer interface [polypeptide binding]; other site
1415784011636	TPP binding site [chemical binding]; other site
1415784011637	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1415784011638	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1415784011639	TPP-binding site [chemical binding]; other site
1415784011640	dimer interface [polypeptide binding]; other site
1415784011641	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1415784011642	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1415784011643	putative valine binding site [chemical binding]; other site
1415784011644	dimer interface [polypeptide binding]; other site
1415784011645	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1415784011646	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1415784011647	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1415784011648	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1415784011649	2-isopropylmalate synthase; Validated; Region: PRK00915
1415784011650	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
1415784011651	active site
1415784011652	catalytic residues [active]
1415784011653	metal binding site [ion binding]; metal-binding site
1415784011654	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
1415784011655	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
1415784011656	tartrate dehydrogenase; Region: TTC; TIGR02089
1415784011657	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1415784011658	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1415784011659	substrate binding site [chemical binding]; other site
1415784011660	ligand binding site [chemical binding]; other site
1415784011661	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1415784011662	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1415784011663	substrate binding site [chemical binding]; other site
1415784011664	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
1415784011665	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1415784011666	dimer interface [polypeptide binding]; other site
1415784011667	motif 1; other site
1415784011668	active site
1415784011669	motif 2; other site
1415784011670	motif 3; other site
1415784011671	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
1415784011672	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
1415784011673	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1415784011674	histidinol dehydrogenase; Region: hisD; TIGR00069
1415784011675	NAD binding site [chemical binding]; other site
1415784011676	dimerization interface [polypeptide binding]; other site
1415784011677	product binding site; other site
1415784011678	substrate binding site [chemical binding]; other site
1415784011679	zinc binding site [ion binding]; other site
1415784011680	catalytic residues [active]
1415784011681	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1415784011682	putative active site pocket [active]
1415784011683	4-fold oligomerization interface [polypeptide binding]; other site
1415784011684	metal binding residues [ion binding]; metal-binding site
1415784011685	3-fold/trimer interface [polypeptide binding]; other site
1415784011686	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
1415784011687	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1415784011688	putative active site [active]
1415784011689	oxyanion strand; other site
1415784011690	catalytic triad [active]
1415784011691	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1415784011692	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
1415784011693	catalytic residues [active]
1415784011694	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1415784011695	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1415784011696	substrate binding site [chemical binding]; other site
1415784011697	glutamase interaction surface [polypeptide binding]; other site
1415784011698	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
1415784011699	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
1415784011700	metal binding site [ion binding]; metal-binding site
1415784011701	histidinol-phosphatase; Validated; Region: PRK06740
1415784011702	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
1415784011703	dimer interface [polypeptide binding]; other site
1415784011704	active site
1415784011705	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178
1415784011706	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1415784011707	putative ligand binding site [chemical binding]; other site
1415784011708	putative NAD binding site [chemical binding]; other site
1415784011709	catalytic site [active]
1415784011710	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
1415784011711	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
1415784011712	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1415784011713	Sulfatase; Region: Sulfatase; pfam00884
1415784011714	Protein of unknown function (DUF3888); Region: DUF3888; pfam13027
1415784011715	diaminopimelate decarboxylase; Region: lysA; TIGR01048
1415784011716	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1415784011717	active site
1415784011718	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1415784011719	substrate binding site [chemical binding]; other site
1415784011720	catalytic residues [active]
1415784011721	dimer interface [polypeptide binding]; other site
1415784011722	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
1415784011723	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1415784011724	Active Sites [active]
1415784011725	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
1415784011726	ATP-sulfurylase; Region: ATPS; cd00517
1415784011727	active site
1415784011728	HXXH motif; other site
1415784011729	flexible loop; other site
1415784011730	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
1415784011731	ligand-binding site [chemical binding]; other site
1415784011732	ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566
1415784011733	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1415784011734	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1415784011735	Protein of unknown function (DUF3906); Region: DUF3906; pfam13046
1415784011736	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1415784011737	diphthine synthase; Region: dph5; TIGR00522
1415784011738	active site
1415784011739	SAM binding site [chemical binding]; other site
1415784011740	homodimer interface [polypeptide binding]; other site
1415784011741	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
1415784011742	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
1415784011743	putative active site [active]
1415784011744	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
1415784011745	putative active site [active]
1415784011746	precorrin-2 dehydrogenase; Reviewed; Region: PRK06718
1415784011747	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
1415784011748	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
1415784011749	Na2 binding site [ion binding]; other site
1415784011750	putative substrate binding site 1 [chemical binding]; other site
1415784011751	Na binding site 1 [ion binding]; other site
1415784011752	putative substrate binding site 2 [chemical binding]; other site
1415784011753	WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868
1415784011754	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1415784011755	Peptidase family M23; Region: Peptidase_M23; pfam01551
1415784011756	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1415784011757	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1415784011758	Protein of unknown function (DUF402); Region: DUF402; cl00979
1415784011759	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
1415784011760	Vpu protein; Region: Vpu; pfam00558
1415784011761	PspA/IM30 family; Region: PspA_IM30; pfam04012
1415784011762	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
1415784011763	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1415784011764	Histidine kinase; Region: HisKA_3; pfam07730
1415784011765	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784011766	ATP binding site [chemical binding]; other site
1415784011767	Mg2+ binding site [ion binding]; other site
1415784011768	G-X-G motif; other site
1415784011769	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1415784011770	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784011771	active site
1415784011772	phosphorylation site [posttranslational modification]
1415784011773	intermolecular recognition site; other site
1415784011774	dimerization interface [polypeptide binding]; other site
1415784011775	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1415784011776	DNA binding residues [nucleotide binding]
1415784011777	dimerization interface [polypeptide binding]; other site
1415784011778	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1415784011779	E3 interaction surface; other site
1415784011780	lipoyl attachment site [posttranslational modification]; other site
1415784011781	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1415784011782	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1415784011783	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784011784	S-adenosylmethionine binding site [chemical binding]; other site
1415784011785	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
1415784011786	Peptidase family M50; Region: Peptidase_M50; pfam02163
1415784011787	active site
1415784011788	putative substrate binding region [chemical binding]; other site
1415784011789	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
1415784011790	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
1415784011791	heme-binding site [chemical binding]; other site
1415784011792	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
1415784011793	FAD binding pocket [chemical binding]; other site
1415784011794	FAD binding motif [chemical binding]; other site
1415784011795	phosphate binding motif [ion binding]; other site
1415784011796	beta-alpha-beta structure motif; other site
1415784011797	NAD binding pocket [chemical binding]; other site
1415784011798	Heme binding  pocket [chemical binding]; other site
1415784011799	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1415784011800	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1415784011801	ligand binding site [chemical binding]; other site
1415784011802	flexible hinge region; other site
1415784011803	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
1415784011804	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1415784011805	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1415784011806	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
1415784011807	Transglycosylase; Region: Transgly; pfam00912
1415784011808	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1415784011809	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1415784011810	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1415784011811	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1415784011812	putative active site [active]
1415784011813	heme pocket [chemical binding]; other site
1415784011814	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1415784011815	dimer interface [polypeptide binding]; other site
1415784011816	phosphorylation site [posttranslational modification]
1415784011817	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784011818	ATP binding site [chemical binding]; other site
1415784011819	Mg2+ binding site [ion binding]; other site
1415784011820	G-X-G motif; other site
1415784011821	Protein of unknown function DUF72; Region: DUF72; pfam01904
1415784011822	Protein of unknown function (DUF3924); Region: DUF3924; pfam13062
1415784011823	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1415784011824	active site
1415784011825	DNA binding site [nucleotide binding]
1415784011826	Int/Topo IB signature motif; other site
1415784011827	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1415784011828	dimerization interface [polypeptide binding]; other site
1415784011829	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1415784011830	dimer interface [polypeptide binding]; other site
1415784011831	phosphorylation site [posttranslational modification]
1415784011832	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784011833	ATP binding site [chemical binding]; other site
1415784011834	Mg2+ binding site [ion binding]; other site
1415784011835	G-X-G motif; other site
1415784011836	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
1415784011837	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
1415784011838	Predicted integral membrane protein [Function unknown]; Region: COG0392
1415784011839	Uncharacterized conserved protein [Function unknown]; Region: COG2898
1415784011840	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1415784011841	Protein of unknown function (DUF3907); Region: DUF3907; pfam13047
1415784011842	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1415784011843	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1415784011844	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1415784011845	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1415784011846	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1415784011847	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
1415784011848	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
1415784011849	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1415784011850	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1415784011851	RNA binding surface [nucleotide binding]; other site
1415784011852	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
1415784011853	active site
1415784011854	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1415784011855	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1415784011856	catalytic residues [active]
1415784011857	Double zinc ribbon; Region: DZR; pfam12773
1415784011858	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333
1415784011859	ResB-like family; Region: ResB; pfam05140
1415784011860	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
1415784011861	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
1415784011862	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1415784011863	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784011864	active site
1415784011865	phosphorylation site [posttranslational modification]
1415784011866	intermolecular recognition site; other site
1415784011867	dimerization interface [polypeptide binding]; other site
1415784011868	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1415784011869	DNA binding site [nucleotide binding]
1415784011870	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
1415784011871	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1415784011872	dimerization interface [polypeptide binding]; other site
1415784011873	PAS domain; Region: PAS; smart00091
1415784011874	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1415784011875	dimer interface [polypeptide binding]; other site
1415784011876	phosphorylation site [posttranslational modification]
1415784011877	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784011878	ATP binding site [chemical binding]; other site
1415784011879	Mg2+ binding site [ion binding]; other site
1415784011880	G-X-G motif; other site
1415784011881	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
1415784011882	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1415784011883	Peptidase family M23; Region: Peptidase_M23; pfam01551
1415784011884	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1415784011885	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1415784011886	Predicted membrane protein [Function unknown]; Region: COG3601
1415784011887	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1415784011888	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
1415784011889	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
1415784011890	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1415784011891	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1415784011892	ATP binding site [chemical binding]; other site
1415784011893	putative Mg++ binding site [ion binding]; other site
1415784011894	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1415784011895	nucleotide binding region [chemical binding]; other site
1415784011896	ATP-binding site [chemical binding]; other site
1415784011897	CAAX protease self-immunity; Region: Abi; pfam02517
1415784011898	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1415784011899	phosphodiesterase YaeI; Provisional; Region: PRK11340
1415784011900	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1415784011901	putative active site [active]
1415784011902	putative metal binding site [ion binding]; other site
1415784011903	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1415784011904	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
1415784011905	DNA binding residues [nucleotide binding]
1415784011906	B12 binding domain; Region: B12-binding_2; pfam02607
1415784011907	adaptor protein; Provisional; Region: PRK02899
1415784011908	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1415784011909	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1415784011910	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
1415784011911	NAD(P) binding site [chemical binding]; other site
1415784011912	Domain of unknown function (DUF3961); Region: DUF3961; pfam13106
1415784011913	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1415784011914	amidase catalytic site [active]
1415784011915	Zn binding residues [ion binding]; other site
1415784011916	substrate binding site [chemical binding]; other site
1415784011917	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
1415784011918	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1415784011919	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1415784011920	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1415784011921	active site
1415784011922	homotetramer interface [polypeptide binding]; other site
1415784011923	homodimer interface [polypeptide binding]; other site
1415784011924	cytidylate kinase; Provisional; Region: cmk; PRK00023
1415784011925	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1415784011926	CMP-binding site; other site
1415784011927	The sites determining sugar specificity; other site
1415784011928	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
1415784011929	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1415784011930	RNA binding site [nucleotide binding]; other site
1415784011931	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1415784011932	RNA binding site [nucleotide binding]; other site
1415784011933	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
1415784011934	RNA binding site [nucleotide binding]; other site
1415784011935	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1415784011936	RNA binding site [nucleotide binding]; other site
1415784011937	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
1415784011938	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
1415784011939	homotetramer interface [polypeptide binding]; other site
1415784011940	FMN binding site [chemical binding]; other site
1415784011941	homodimer contacts [polypeptide binding]; other site
1415784011942	putative active site [active]
1415784011943	putative substrate binding site [chemical binding]; other site
1415784011944	YIEGIA protein; Region: YIEGIA; pfam14045
1415784011945	GTP-binding protein Der; Reviewed; Region: PRK00093
1415784011946	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1415784011947	G1 box; other site
1415784011948	GTP/Mg2+ binding site [chemical binding]; other site
1415784011949	Switch I region; other site
1415784011950	G2 box; other site
1415784011951	Switch II region; other site
1415784011952	G3 box; other site
1415784011953	G4 box; other site
1415784011954	G5 box; other site
1415784011955	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1415784011956	G1 box; other site
1415784011957	GTP/Mg2+ binding site [chemical binding]; other site
1415784011958	Switch I region; other site
1415784011959	G2 box; other site
1415784011960	G3 box; other site
1415784011961	Switch II region; other site
1415784011962	G4 box; other site
1415784011963	G5 box; other site
1415784011964	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1415784011965	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1415784011966	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1415784011967	Stage VI sporulation protein F; Region: SpoVIF; pfam14069
1415784011968	Protein of unknown function (DUF2768); Region: DUF2768; pfam10966
1415784011969	Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547
1415784011970	stage IV sporulation protein A; Region: spore_IV_A; TIGR02836
1415784011971	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1415784011972	IHF dimer interface [polypeptide binding]; other site
1415784011973	IHF - DNA interface [nucleotide binding]; other site
1415784011974	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
1415784011975	homodecamer interface [polypeptide binding]; other site
1415784011976	GTP cyclohydrolase I; Provisional; Region: PLN03044
1415784011977	active site
1415784011978	putative catalytic site residues [active]
1415784011979	zinc binding site [ion binding]; other site
1415784011980	GTP-CH-I/GFRP interaction surface; other site
1415784011981	Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307
1415784011982	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
1415784011983	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784011984	S-adenosylmethionine binding site [chemical binding]; other site
1415784011985	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1415784011986	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1415784011987	substrate binding pocket [chemical binding]; other site
1415784011988	chain length determination region; other site
1415784011989	substrate-Mg2+ binding site; other site
1415784011990	catalytic residues [active]
1415784011991	aspartate-rich region 1; other site
1415784011992	active site lid residues [active]
1415784011993	aspartate-rich region 2; other site
1415784011994	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1415784011995	active site
1415784011996	multimer interface [polypeptide binding]; other site
1415784011997	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1415784011998	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1415784011999	Tetramer interface [polypeptide binding]; other site
1415784012000	active site
1415784012001	FMN-binding site [chemical binding]; other site
1415784012002	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1415784012003	active site
1415784012004	dimer interface [polypeptide binding]; other site
1415784012005	metal binding site [ion binding]; metal-binding site
1415784012006	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
1415784012007	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1415784012008	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784012009	homodimer interface [polypeptide binding]; other site
1415784012010	catalytic residue [active]
1415784012011	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1415784012012	TPR motif; other site
1415784012013	binding surface
1415784012014	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1415784012015	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1415784012016	binding surface
1415784012017	TPR motif; other site
1415784012018	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
1415784012019	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1415784012020	binding surface
1415784012021	TPR motif; other site
1415784012022	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1415784012023	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1415784012024	binding surface
1415784012025	TPR motif; other site
1415784012026	hypothetical protein; Provisional; Region: PRK03636
1415784012027	UPF0302 domain; Region: UPF0302; pfam08864
1415784012028	IDEAL domain; Region: IDEAL; pfam08858
1415784012029	Protein of unknown function (DUF2487); Region: DUF2487; pfam10673
1415784012030	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
1415784012031	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
1415784012032	iron-sulfur cluster [ion binding]; other site
1415784012033	[2Fe-2S] cluster binding site [ion binding]; other site
1415784012034	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
1415784012035	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
1415784012036	interchain domain interface [polypeptide binding]; other site
1415784012037	intrachain domain interface; other site
1415784012038	heme bH binding site [chemical binding]; other site
1415784012039	Qi binding site; other site
1415784012040	heme bL binding site [chemical binding]; other site
1415784012041	Qo binding site; other site
1415784012042	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
1415784012043	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
1415784012044	interchain domain interface [polypeptide binding]; other site
1415784012045	intrachain domain interface; other site
1415784012046	Qi binding site; other site
1415784012047	Qo binding site; other site
1415784012048	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1415784012049	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1415784012050	Protein of unknown function (DUF1405); Region: DUF1405; pfam07187
1415784012051	Protein of unknown function (DUF1461); Region: DUF1461; pfam07314
1415784012052	Protein of unknown function (DUF1461); Region: DUF1461; cl01862
1415784012053	Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800
1415784012054	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
1415784012055	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
1415784012056	active site
1415784012057	Fe-S cluster binding site [ion binding]; other site
1415784012058	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1415784012059	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1415784012060	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1415784012061	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1415784012062	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
1415784012063	homodimer interface [polypeptide binding]; other site
1415784012064	metal binding site [ion binding]; metal-binding site
1415784012065	dihydrodipicolinate reductase; Provisional; Region: PRK00048
1415784012066	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1415784012067	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1415784012068	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
1415784012069	active site
1415784012070	dimer interfaces [polypeptide binding]; other site
1415784012071	catalytic residues [active]
1415784012072	bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001
1415784012073	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
1415784012074	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
1415784012075	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
1415784012076	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1415784012077	active site
1415784012078	NTP binding site [chemical binding]; other site
1415784012079	metal binding triad [ion binding]; metal-binding site
1415784012080	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1415784012081	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
1415784012082	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
1415784012083	Biotin operon repressor [Transcription]; Region: BirA; COG1654
1415784012084	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
1415784012085	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
1415784012086	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
1415784012087	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
1415784012088	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1415784012089	oligomerization interface [polypeptide binding]; other site
1415784012090	active site
1415784012091	metal binding site [ion binding]; metal-binding site
1415784012092	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1415784012093	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1415784012094	active site
1415784012095	ATP-binding site [chemical binding]; other site
1415784012096	pantoate-binding site; other site
1415784012097	HXXH motif; other site
1415784012098	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
1415784012099	tetramerization interface [polypeptide binding]; other site
1415784012100	active site
1415784012101	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074
1415784012102	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1415784012103	active site
1415784012104	catalytic site [active]
1415784012105	substrate binding site [chemical binding]; other site
1415784012106	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
1415784012107	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1415784012108	putative Mg++ binding site [ion binding]; other site
1415784012109	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1415784012110	Protein of unknown function (DUF4264); Region: DUF4264; pfam14084
1415784012111	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
1415784012112	aspartate aminotransferase; Provisional; Region: PRK05764
1415784012113	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1415784012114	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784012115	homodimer interface [polypeptide binding]; other site
1415784012116	catalytic residue [active]
1415784012117	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
1415784012118	Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
1415784012119	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1415784012120	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1415784012121	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1415784012122	minor groove reading motif; other site
1415784012123	helix-hairpin-helix signature motif; other site
1415784012124	substrate binding pocket [chemical binding]; other site
1415784012125	active site
1415784012126	Transglycosylase; Region: Transgly; pfam00912
1415784012127	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1415784012128	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1415784012129	Fibronectin type III domain; Region: fn3; pfam00041
1415784012130	Recombination protein U; Region: RecU; cl01314
1415784012131	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
1415784012132	Protein of unknown function (DUF2515); Region: DUF2515; pfam10720
1415784012133	Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807
1415784012134	YppF-like protein; Region: YppF; pfam14178
1415784012135	YppG-like protein; Region: YppG; pfam14179
1415784012136	Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122
1415784012137	hypothetical protein; Provisional; Region: PRK13660
1415784012138	cell division protein GpsB; Provisional; Region: PRK14127
1415784012139	DivIVA domain; Region: DivI1A_domain; TIGR03544
1415784012140	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
1415784012141	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
1415784012142	Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170
1415784012143	Protein of unknown function (DUF3921); Region: DUF3921; pfam13060
1415784012144	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
1415784012145	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
1415784012146	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1415784012147	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
1415784012148	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
1415784012149	active site
1415784012150	Zn binding site [ion binding]; other site
1415784012151	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1415784012152	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1415784012153	Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152
1415784012154	Phosphotransferase enzyme family; Region: APH; pfam01636
1415784012155	putative active site [active]
1415784012156	putative substrate binding site [chemical binding]; other site
1415784012157	ATP binding site [chemical binding]; other site
1415784012158	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1415784012159	active site
1415784012160	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1415784012161	active site
1415784012162	xanthine permease; Region: pbuX; TIGR03173
1415784012163	Predicted membrane protein [Function unknown]; Region: COG2311
1415784012164	Protein of unknown function (DUF418); Region: DUF418; cl12135
1415784012165	Protein of unknown function (DUF418); Region: DUF418; pfam04235
1415784012166	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
1415784012167	Dynamin family; Region: Dynamin_N; pfam00350
1415784012168	G1 box; other site
1415784012169	GTP/Mg2+ binding site [chemical binding]; other site
1415784012170	G2 box; other site
1415784012171	Switch I region; other site
1415784012172	G3 box; other site
1415784012173	Switch II region; other site
1415784012174	G4 box; other site
1415784012175	G5 box; other site
1415784012176	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1415784012177	Dynamin family; Region: Dynamin_N; pfam00350
1415784012178	G1 box; other site
1415784012179	GTP/Mg2+ binding site [chemical binding]; other site
1415784012180	G2 box; other site
1415784012181	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
1415784012182	G3 box; other site
1415784012183	Switch II region; other site
1415784012184	GTP/Mg2+ binding site [chemical binding]; other site
1415784012185	G4 box; other site
1415784012186	G5 box; other site
1415784012187	Protein of unknown function (DUF3931); Region: DUF3931; pfam13082
1415784012188	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784012189	Coenzyme A binding pocket [chemical binding]; other site
1415784012190	Protein of unknown function (DUF2533); Region: DUF2533; pfam10752
1415784012191	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1415784012192	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1415784012193	active site residue [active]
1415784012194	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1415784012195	active site residue [active]
1415784012196	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1415784012197	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1415784012198	Probable transposase; Region: OrfB_IS605; pfam01385
1415784012199	Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503
1415784012200	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
1415784012201	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
1415784012202	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
1415784012203	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1415784012204	5'-3' exonuclease; Region: 53EXOc; smart00475
1415784012205	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1415784012206	active site
1415784012207	metal binding site 1 [ion binding]; metal-binding site
1415784012208	putative 5' ssDNA interaction site; other site
1415784012209	metal binding site 3; metal-binding site
1415784012210	metal binding site 2 [ion binding]; metal-binding site
1415784012211	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1415784012212	putative DNA binding site [nucleotide binding]; other site
1415784012213	putative metal binding site [ion binding]; other site
1415784012214	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784012215	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784012216	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784012217	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784012218	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784012219	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784012220	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784012221	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784012222	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784012223	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784012224	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784012225	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784012226	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784012227	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784012228	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784012229	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784012230	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784012231	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784012232	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784012233	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784012234	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784012235	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784012236	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784012237	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784012238	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784012239	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784012240	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784012241	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1415784012242	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784012243	Coenzyme A binding pocket [chemical binding]; other site
1415784012244	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
1415784012245	Isochorismatase family; Region: Isochorismatase; pfam00857
1415784012246	catalytic triad [active]
1415784012247	conserved cis-peptide bond; other site
1415784012248	EamA-like transporter family; Region: EamA; pfam00892
1415784012249	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1415784012250	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
1415784012251	RNA/DNA hybrid binding site [nucleotide binding]; other site
1415784012252	active site
1415784012253	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
1415784012254	active site
1415784012255	catalytic residues [active]
1415784012256	QueT transporter; Region: QueT; pfam06177
1415784012257	hypothetical protein; Validated; Region: PRK07708
1415784012258	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
1415784012259	RNA/DNA hybrid binding site [nucleotide binding]; other site
1415784012260	active site
1415784012261	Protein of unknown function (DUF2602); Region: DUF2602; pfam10782
1415784012262	Protein of unknown function (DUF2564); Region: DUF2564; pfam10819
1415784012263	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1415784012264	DNA-binding site [nucleotide binding]; DNA binding site
1415784012265	RNA-binding motif; other site
1415784012266	YqcI/YcgG family; Region: YqcI_YcgG; pfam08892
1415784012267	LysE type translocator; Region: LysE; pfam01810
1415784012268	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
1415784012269	Protein of unknown function, DUF485; Region: DUF485; pfam04341
1415784012270	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1415784012271	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
1415784012272	Na binding site [ion binding]; other site
1415784012273	aminotransferase; Validated; Region: PRK07678
1415784012274	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1415784012275	inhibitor-cofactor binding pocket; inhibition site
1415784012276	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784012277	catalytic residue [active]
1415784012278	Protein of unknown function (DUF3986); Region: DUF3986; pfam13143
1415784012279	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1415784012280	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1415784012281	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1415784012282	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
1415784012283	DNA binding residues [nucleotide binding]
1415784012284	drug binding residues [chemical binding]; other site
1415784012285	dimer interface [polypeptide binding]; other site
1415784012286	Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978
1415784012287	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
1415784012288	multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575
1415784012289	Predicted membrane protein [Function unknown]; Region: COG2323
1415784012290	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1415784012291	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1415784012292	putative active site [active]
1415784012293	Tic20-like protein; Region: Tic20; pfam09685
1415784012294	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
1415784012295	dimer interface [polypeptide binding]; other site
1415784012296	FMN binding site [chemical binding]; other site
1415784012297	NADPH bind site [chemical binding]; other site
1415784012298	RNA polymerase factor sigma-70; Validated; Region: PRK06811
1415784012299	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1415784012300	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1415784012301	DNA binding residues [nucleotide binding]
1415784012302	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1415784012303	H+ Antiporter protein; Region: 2A0121; TIGR00900
1415784012304	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784012305	putative substrate translocation pore; other site
1415784012306	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1415784012307	active site
1415784012308	metal binding site [ion binding]; metal-binding site
1415784012309	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1415784012310	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
1415784012311	bacterial Hfq-like; Region: Hfq; cd01716
1415784012312	hexamer interface [polypeptide binding]; other site
1415784012313	Sm1 motif; other site
1415784012314	RNA binding site [nucleotide binding]; other site
1415784012315	Sm2 motif; other site
1415784012316	HD domain; Region: HD_3; pfam13023
1415784012317	flagellar motor protein MotP; Reviewed; Region: PRK06743
1415784012318	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
1415784012319	flagellar motor protein MotS; Reviewed; Region: PRK06742
1415784012320	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1415784012321	ligand binding site [chemical binding]; other site
1415784012322	Response regulator receiver domain; Region: Response_reg; pfam00072
1415784012323	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784012324	active site
1415784012325	phosphorylation site [posttranslational modification]
1415784012326	intermolecular recognition site; other site
1415784012327	dimerization interface [polypeptide binding]; other site
1415784012328	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
1415784012329	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1415784012330	putative binding surface; other site
1415784012331	active site
1415784012332	P2 response regulator binding domain; Region: P2; pfam07194
1415784012333	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
1415784012334	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784012335	ATP binding site [chemical binding]; other site
1415784012336	Mg2+ binding site [ion binding]; other site
1415784012337	G-X-G motif; other site
1415784012338	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
1415784012339	flagellar motor switch protein; Reviewed; Region: PRK06782
1415784012340	CheC-like family; Region: CheC; pfam04509
1415784012341	CheC-like family; Region: CheC; pfam04509
1415784012342	CheC-like family; Region: CheC; pfam04509
1415784012343	CheC-like family; Region: CheC; pfam04509
1415784012344	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
1415784012345	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
1415784012346	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1415784012347	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
1415784012348	Protein of unknown function (DUF327); Region: DUF327; pfam03885
1415784012349	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799
1415784012350	Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040
1415784012351	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073
1415784012352	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1415784012353	flagellar capping protein; Validated; Region: fliD; PRK06798
1415784012354	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
1415784012355	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
1415784012356	Flagellar protein FliS; Region: FliS; cl00654
1415784012357	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797
1415784012358	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
1415784012359	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
1415784012360	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1415784012361	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699
1415784012362	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
1415784012363	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
1415784012364	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
1415784012365	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
1415784012366	FliG C-terminal domain; Region: FliG_C; pfam01706
1415784012367	flagellar assembly protein H; Validated; Region: fliH; PRK06800
1415784012368	flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793
1415784012369	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1415784012370	Walker A motif; other site
1415784012371	ATP binding site [chemical binding]; other site
1415784012372	Walker B motif; other site
1415784012373	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
1415784012374	flagellar basal body rod modification protein; Validated; Region: flgD; PRK06792
1415784012375	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
1415784012376	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
1415784012377	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1415784012378	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
1415784012379	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1415784012380	Protein of unknown function (DUF3964); Region: DUF3964; pfam13107
1415784012381	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
1415784012382	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1415784012383	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784012384	active site
1415784012385	phosphorylation site [posttranslational modification]
1415784012386	intermolecular recognition site; other site
1415784012387	dimerization interface [polypeptide binding]; other site
1415784012388	DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181
1415784012389	flagellin; Provisional; Region: PRK12807
1415784012390	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1415784012391	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1415784012392	flagellin; Reviewed; Region: PRK08869
1415784012393	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1415784012394	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1415784012395	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1415784012396	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1415784012397	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1415784012398	catalytic residue [active]
1415784012399	flagellar motor switch protein; Validated; Region: PRK06789
1415784012400	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
1415784012401	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
1415784012402	flagellar motor switch protein; Validated; Region: PRK06788
1415784012403	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
1415784012404	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
1415784012405	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
1415784012406	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
1415784012407	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
1415784012408	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
1415784012409	FHIPEP family; Region: FHIPEP; pfam00771
1415784012410	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK11889
1415784012411	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1415784012412	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819
1415784012413	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1415784012414	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1415784012415	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1415784012416	Predicted transcriptional regulators [Transcription]; Region: COG1378
1415784012417	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
1415784012418	Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124
1415784012419	C-terminal domain interface [polypeptide binding]; other site
1415784012420	sugar binding site [chemical binding]; other site
1415784012421	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
1415784012422	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
1415784012423	Protein of unknown function (DUF3951); Region: DUF3951; pfam13131
1415784012424	Dienelactone hydrolase family; Region: DLH; pfam01738
1415784012425	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1415784012426	small acid-soluble spore protein, H-type; Region: SASP_H; TIGR02861
1415784012427	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1415784012428	non-specific DNA binding site [nucleotide binding]; other site
1415784012429	salt bridge; other site
1415784012430	sequence-specific DNA binding site [nucleotide binding]; other site
1415784012431	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784012432	H+ Antiporter protein; Region: 2A0121; TIGR00900
1415784012433	putative substrate translocation pore; other site
1415784012434	Domain of unknown function (DUF4398); Region: DUF4398; pfam14346
1415784012435	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1415784012436	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1415784012437	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1415784012438	dimerization interface [polypeptide binding]; other site
1415784012439	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1415784012440	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1415784012441	Walker A/P-loop; other site
1415784012442	ATP binding site [chemical binding]; other site
1415784012443	Q-loop/lid; other site
1415784012444	ABC transporter signature motif; other site
1415784012445	Walker B; other site
1415784012446	D-loop; other site
1415784012447	H-loop/switch region; other site
1415784012448	2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046
1415784012449	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1415784012450	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1415784012451	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784012452	dimer interface [polypeptide binding]; other site
1415784012453	conserved gate region; other site
1415784012454	putative PBP binding loops; other site
1415784012455	ABC-ATPase subunit interface; other site
1415784012456	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784012457	dimer interface [polypeptide binding]; other site
1415784012458	conserved gate region; other site
1415784012459	putative PBP binding loops; other site
1415784012460	ABC-ATPase subunit interface; other site
1415784012461	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
1415784012462	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
1415784012463	Beta-Casp domain; Region: Beta-Casp; smart01027
1415784012464	Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787
1415784012465	Cupin; Region: Cupin_1; smart00835
1415784012466	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1415784012467	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1415784012468	catalytic core [active]
1415784012469	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1415784012470	hypothetical protein; Provisional; Region: PRK09272
1415784012471	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1415784012472	MarR family; Region: MarR; pfam01047
1415784012473	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
1415784012474	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1415784012475	active site
1415784012476	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
1415784012477	dimer interface [polypeptide binding]; other site
1415784012478	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1415784012479	Ligand Binding Site [chemical binding]; other site
1415784012480	Molecular Tunnel; other site
1415784012481	RNA polymerase factor sigma-70; Validated; Region: PRK06811
1415784012482	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1415784012483	DNA binding residues [nucleotide binding]
1415784012484	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
1415784012485	VPS10 domain; Region: VPS10; smart00602
1415784012486	VPS10 domain; Region: VPS10; smart00602
1415784012487	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1415784012488	Protein of unknown function (DUF3940); Region: DUF3940; pfam13076
1415784012489	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1415784012490	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1415784012491	DNA-binding site [nucleotide binding]; DNA binding site
1415784012492	FCD domain; Region: FCD; pfam07729
1415784012493	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1415784012494	EamA-like transporter family; Region: EamA; pfam00892
1415784012495	EamA-like transporter family; Region: EamA; pfam00892
1415784012496	Domain of unknown function (DUF3784); Region: DUF3784; pfam12650
1415784012497	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1415784012498	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1415784012499	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1415784012500	Methyltransferase domain; Region: Methyltransf_24; pfam13578
1415784012501	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
1415784012502	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1415784012503	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1415784012504	DNA binding residues [nucleotide binding]
1415784012505	putative dimer interface [polypeptide binding]; other site
1415784012506	short chain dehydrogenase; Provisional; Region: PRK06123
1415784012507	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1415784012508	NAD(P) binding site [chemical binding]; other site
1415784012509	active site
1415784012510	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1415784012511	Class II fumarases; Region: Fumarase_classII; cd01362
1415784012512	active site
1415784012513	tetramer interface [polypeptide binding]; other site
1415784012514	Domain of unknown function (DUF1200); Region: DUF1200; pfam06713
1415784012515	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
1415784012516	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1415784012517	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
1415784012518	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
1415784012519	active site pocket [active]
1415784012520	oxyanion hole [active]
1415784012521	catalytic triad [active]
1415784012522	active site nucleophile [active]
1415784012523	Protein of unknown function (DUF3942); Region: DUF3942; pfam13078
1415784012524	Penicillinase repressor; Region: Pencillinase_R; pfam03965
1415784012525	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
1415784012526	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1415784012527	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
1415784012528	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1415784012529	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1415784012530	catalytic residues [active]
1415784012531	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
1415784012532	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
1415784012533	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1415784012534	non-specific DNA binding site [nucleotide binding]; other site
1415784012535	salt bridge; other site
1415784012536	sequence-specific DNA binding site [nucleotide binding]; other site
1415784012537	Cupin domain; Region: Cupin_2; pfam07883
1415784012538	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
1415784012539	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
1415784012540	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1415784012541	catalytic residue [active]
1415784012542	Protein of unknown function (DUF445); Region: DUF445; pfam04286
1415784012543	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
1415784012544	RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642
1415784012545	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1415784012546	DNA binding residues [nucleotide binding]
1415784012547	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1415784012548	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784012549	active site
1415784012550	phosphorylation site [posttranslational modification]
1415784012551	intermolecular recognition site; other site
1415784012552	dimerization interface [polypeptide binding]; other site
1415784012553	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1415784012554	DNA binding residues [nucleotide binding]
1415784012555	dimerization interface [polypeptide binding]; other site
1415784012556	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1415784012557	Histidine kinase; Region: HisKA_3; pfam07730
1415784012558	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1415784012559	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1415784012560	Walker A/P-loop; other site
1415784012561	ATP binding site [chemical binding]; other site
1415784012562	Q-loop/lid; other site
1415784012563	ABC transporter signature motif; other site
1415784012564	Walker B; other site
1415784012565	D-loop; other site
1415784012566	H-loop/switch region; other site
1415784012567	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1415784012568	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1415784012569	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1415784012570	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1415784012571	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1415784012572	PLD-like domain; Region: PLDc_2; pfam13091
1415784012573	putative active site [active]
1415784012574	catalytic site [active]
1415784012575	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1415784012576	PLD-like domain; Region: PLDc_2; pfam13091
1415784012577	putative active site [active]
1415784012578	catalytic site [active]
1415784012579	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1415784012580	putative nucleotide binding site [chemical binding]; other site
1415784012581	uridine monophosphate binding site [chemical binding]; other site
1415784012582	homohexameric interface [polypeptide binding]; other site
1415784012583	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1415784012584	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1415784012585	aspartate ammonia-lyase; Provisional; Region: PRK14515
1415784012586	Aspartase; Region: Aspartase; cd01357
1415784012587	active sites [active]
1415784012588	tetramer interface [polypeptide binding]; other site
1415784012589	malate dehydrogenase; Provisional; Region: PRK13529
1415784012590	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1415784012591	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
1415784012592	NAD(P) binding site [chemical binding]; other site
1415784012593	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1415784012594	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784012595	ATP binding site [chemical binding]; other site
1415784012596	Mg2+ binding site [ion binding]; other site
1415784012597	G-X-G motif; other site
1415784012598	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784012599	Response regulator receiver domain; Region: Response_reg; pfam00072
1415784012600	active site
1415784012601	phosphorylation site [posttranslational modification]
1415784012602	intermolecular recognition site; other site
1415784012603	dimerization interface [polypeptide binding]; other site
1415784012604	YcbB domain; Region: YcbB; pfam08664
1415784012605	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1415784012606	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1415784012607	putative Zn2+ binding site [ion binding]; other site
1415784012608	putative DNA binding site [nucleotide binding]; other site
1415784012609	dimerization interface [polypeptide binding]; other site
1415784012610	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784012611	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1415784012612	putative substrate translocation pore; other site
1415784012613	SWIM zinc finger; Region: SWIM; pfam04434
1415784012614	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
1415784012615	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
1415784012616	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1415784012617	ATP binding site [chemical binding]; other site
1415784012618	putative Mg++ binding site [ion binding]; other site
1415784012619	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1415784012620	nucleotide binding region [chemical binding]; other site
1415784012621	ATP-binding site [chemical binding]; other site
1415784012622	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
1415784012623	dimer interface [polypeptide binding]; other site
1415784012624	active site
1415784012625	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1415784012626	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1415784012627	non-specific DNA binding site [nucleotide binding]; other site
1415784012628	salt bridge; other site
1415784012629	sequence-specific DNA binding site [nucleotide binding]; other site
1415784012630	aspartate kinase; Reviewed; Region: PRK06635
1415784012631	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
1415784012632	putative nucleotide binding site [chemical binding]; other site
1415784012633	putative catalytic residues [active]
1415784012634	putative Mg ion binding site [ion binding]; other site
1415784012635	putative aspartate binding site [chemical binding]; other site
1415784012636	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
1415784012637	putative allosteric regulatory site; other site
1415784012638	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
1415784012639	putative allosteric regulatory residue; other site
1415784012640	DoxX-like family; Region: DoxX_3; pfam13781
1415784012641	Domain of unknown function (DUF4166); Region: DUF4166; pfam13761
1415784012642	YndJ-like protein; Region: YndJ; pfam14158
1415784012643	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
1415784012644	putative active site [active]
1415784012645	nucleotide binding site [chemical binding]; other site
1415784012646	nudix motif; other site
1415784012647	putative metal binding site [ion binding]; other site
1415784012648	H+ Antiporter protein; Region: 2A0121; TIGR00900
1415784012649	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784012650	putative substrate translocation pore; other site
1415784012651	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
1415784012652	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784012653	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1415784012654	putative substrate translocation pore; other site
1415784012655	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879
1415784012656	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1415784012657	dimer interface [polypeptide binding]; other site
1415784012658	active site
1415784012659	CoA binding pocket [chemical binding]; other site
1415784012660	NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512
1415784012661	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
1415784012662	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1415784012663	HflX GTPase family; Region: HflX; cd01878
1415784012664	G1 box; other site
1415784012665	GTP/Mg2+ binding site [chemical binding]; other site
1415784012666	Switch I region; other site
1415784012667	G2 box; other site
1415784012668	G3 box; other site
1415784012669	Switch II region; other site
1415784012670	G4 box; other site
1415784012671	G5 box; other site
1415784012672	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784012673	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1415784012674	putative substrate translocation pore; other site
1415784012675	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1415784012676	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1415784012677	dimer interface [polypeptide binding]; other site
1415784012678	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784012679	catalytic residue [active]
1415784012680	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784012681	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1415784012682	Coenzyme A binding pocket [chemical binding]; other site
1415784012683	Domain of unknown function (DUF4037); Region: DUF4037; pfam13228
1415784012684	stage V sporulation protein B; Region: spore_V_B; TIGR02900
1415784012685	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1415784012686	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
1415784012687	Na2 binding site [ion binding]; other site
1415784012688	putative substrate binding site 1 [chemical binding]; other site
1415784012689	Na binding site 1 [ion binding]; other site
1415784012690	putative substrate binding site 2 [chemical binding]; other site
1415784012691	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1415784012692	Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956
1415784012693	NodB motif; other site
1415784012694	putative active site [active]
1415784012695	putative catalytic site [active]
1415784012696	putative Zn binding site [ion binding]; other site
1415784012697	Mor transcription activator family; Region: Mor; cl02360
1415784012698	Predicted membrane protein [Function unknown]; Region: COG2323
1415784012699	Fibronectin-binding protein (FBP); Region: FBP; pfam07299
1415784012700	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1415784012701	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1415784012702	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1415784012703	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1415784012704	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1415784012705	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1415784012706	methionine sulfoxide reductase A; Provisional; Region: PRK14054
1415784012707	short chain dehydrogenase; Provisional; Region: PRK12747
1415784012708	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
1415784012709	NADP binding site [chemical binding]; other site
1415784012710	homodimer interface [polypeptide binding]; other site
1415784012711	active site
1415784012712	substrate binding site [chemical binding]; other site
1415784012713	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1415784012714	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
1415784012715	homodimer interface [polypeptide binding]; other site
1415784012716	substrate-cofactor binding pocket; other site
1415784012717	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784012718	catalytic residue [active]
1415784012719	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06725
1415784012720	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1415784012721	PYR/PP interface [polypeptide binding]; other site
1415784012722	dimer interface [polypeptide binding]; other site
1415784012723	TPP binding site [chemical binding]; other site
1415784012724	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1415784012725	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1415784012726	TPP-binding site [chemical binding]; other site
1415784012727	dimer interface [polypeptide binding]; other site
1415784012728	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1415784012729	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1415784012730	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1415784012731	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1415784012732	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
1415784012733	threonine dehydratase; Validated; Region: PRK08639
1415784012734	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1415784012735	tetramer interface [polypeptide binding]; other site
1415784012736	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784012737	catalytic residue [active]
1415784012738	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
1415784012739	putative Ile/Val binding site [chemical binding]; other site
1415784012740	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
1415784012741	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
1415784012742	putative active site [active]
1415784012743	putative metal binding site [ion binding]; other site
1415784012744	Protein of unknown function (DUF554); Region: DUF554; pfam04474
1415784012745	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1415784012746	Coenzyme A binding pocket [chemical binding]; other site
1415784012747	drug efflux system protein MdtG; Provisional; Region: PRK09874
1415784012748	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784012749	putative substrate translocation pore; other site
1415784012750	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
1415784012751	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
1415784012752	putative active site [active]
1415784012753	metal binding site [ion binding]; metal-binding site
1415784012754	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1415784012755	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1415784012756	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
1415784012757	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1415784012758	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784012759	Coenzyme A binding pocket [chemical binding]; other site
1415784012760	5-methylthioadenosine/S-adenosylhomocysteine deaminase; Provisional; Region: PRK15493
1415784012761	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
1415784012762	active site
1415784012763	putative substrate binding pocket [chemical binding]; other site
1415784012764	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1415784012765	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1415784012766	peptide binding site [polypeptide binding]; other site
1415784012767	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784012768	S-adenosylmethionine binding site [chemical binding]; other site
1415784012769	radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053
1415784012770	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1415784012771	FeS/SAM binding site; other site
1415784012772	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1415784012773	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1415784012774	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784012775	Coenzyme A binding pocket [chemical binding]; other site
1415784012776	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1415784012777	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1415784012778	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784012779	active site
1415784012780	phosphorylation site [posttranslational modification]
1415784012781	intermolecular recognition site; other site
1415784012782	dimerization interface [polypeptide binding]; other site
1415784012783	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1415784012784	DNA binding site [nucleotide binding]
1415784012785	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1415784012786	dimerization interface [polypeptide binding]; other site
1415784012787	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1415784012788	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1415784012789	dimer interface [polypeptide binding]; other site
1415784012790	phosphorylation site [posttranslational modification]
1415784012791	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784012792	ATP binding site [chemical binding]; other site
1415784012793	Mg2+ binding site [ion binding]; other site
1415784012794	G-X-G motif; other site
1415784012795	Peptidase family M23; Region: Peptidase_M23; pfam01551
1415784012796	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1415784012797	manganese transport protein MntH; Reviewed; Region: PRK00701
1415784012798	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1415784012799	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
1415784012800	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
1415784012801	active site residue [active]
1415784012802	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
1415784012803	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
1415784012804	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1415784012805	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1415784012806	Amino acid permease; Region: AA_permease_2; pfam13520
1415784012807	Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791
1415784012808	Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791
1415784012809	Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791
1415784012810	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1415784012811	CAAX protease self-immunity; Region: Abi; pfam02517
1415784012812	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1415784012813	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1415784012814	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1415784012815	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1415784012816	DNA binding residues [nucleotide binding]
1415784012817	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1415784012818	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1415784012819	intersubunit interface [polypeptide binding]; other site
1415784012820	active site
1415784012821	catalytic residue [active]
1415784012822	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1415784012823	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1415784012824	Nucleoside recognition; Region: Gate; pfam07670
1415784012825	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1415784012826	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
1415784012827	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1415784012828	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1415784012829	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
1415784012830	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1415784012831	active site
1415784012832	catalytic motif [active]
1415784012833	Zn binding site [ion binding]; other site
1415784012834	Protein of unknown function (DUF1453); Region: DUF1453; pfam07301
1415784012835	hypothetical protein; Provisional; Region: PRK01631
1415784012836	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
1415784012837	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1415784012838	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1415784012839	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1415784012840	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1415784012841	dimerization interface [polypeptide binding]; other site
1415784012842	Family description; Region: DsbD_2; pfam13386
1415784012843	VPS10 domain; Region: VPS10; smart00602
1415784012844	proline aminopeptidase P II; Provisional; Region: PRK10879
1415784012845	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
1415784012846	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
1415784012847	active site
1415784012848	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
1415784012849	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1415784012850	Multicopper oxidase; Region: Cu-oxidase; pfam00394
1415784012851	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1415784012852	Bacterial SH3 domain; Region: SH3_3; pfam08239
1415784012853	Bacterial SH3 domain; Region: SH3_3; pfam08239
1415784012854	Bacterial SH3 domain; Region: SH3_3; pfam08239
1415784012855	Bacterial SH3 domain; Region: SH3_3; pfam08239
1415784012856	Bacterial SH3 domain; Region: SH3_3; pfam08239
1415784012857	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1415784012858	Peptidase family M23; Region: Peptidase_M23; pfam01551
1415784012859	Protein of unknown function (DUF1510); Region: DUF1510; pfam07423
1415784012860	Protein of unknown function (DUF1510); Region: DUF1510; pfam07423
1415784012861	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
1415784012862	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
1415784012863	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
1415784012864	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
1415784012865	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
1415784012866	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1415784012867	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1415784012868	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1415784012869	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
1415784012870	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
1415784012871	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1415784012872	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
1415784012873	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1415784012874	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784012875	ATP binding site [chemical binding]; other site
1415784012876	G-X-G motif; other site
1415784012877	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
1415784012878	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1415784012879	active site
1415784012880	ATP binding site [chemical binding]; other site
1415784012881	substrate binding site [chemical binding]; other site
1415784012882	Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009
1415784012883	Zn binding site [ion binding]; other site
1415784012884	Protein of unknown function (DUF2602); Region: DUF2602; pfam10782
1415784012885	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
1415784012886	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
1415784012887	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
1415784012888	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1415784012889	MgtE intracellular N domain; Region: MgtE_N; pfam03448
1415784012890	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1415784012891	Divalent cation transporter; Region: MgtE; pfam01769
1415784012892	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
1415784012893	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1415784012894	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
1415784012895	VPS10 domain; Region: VPS10; smart00602
1415784012896	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1415784012897	DNA binding site [nucleotide binding]
1415784012898	active site
1415784012899	Int/Topo IB signature motif; other site
1415784012900	catalytic residues [active]
1415784012901	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1415784012902	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1415784012903	Beta-lactamase; Region: Beta-lactamase; pfam00144
1415784012904	Beta-lactamase; Region: Beta-lactamase; pfam00144
1415784012905	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1415784012906	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1415784012907	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1415784012908	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1415784012909	Histidine kinase; Region: HisKA_3; pfam07730
1415784012910	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784012911	ATP binding site [chemical binding]; other site
1415784012912	Mg2+ binding site [ion binding]; other site
1415784012913	G-X-G motif; other site
1415784012914	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1415784012915	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784012916	active site
1415784012917	phosphorylation site [posttranslational modification]
1415784012918	intermolecular recognition site; other site
1415784012919	dimerization interface [polypeptide binding]; other site
1415784012920	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1415784012921	DNA binding residues [nucleotide binding]
1415784012922	dimerization interface [polypeptide binding]; other site
1415784012923	Putative sensor; Region: Sensor; pfam13796
1415784012924	Erythromycin esterase; Region: Erythro_esteras; pfam05139
1415784012925	CAAX protease self-immunity; Region: Abi; pfam02517
1415784012926	DNA topoisomerase III; Provisional; Region: PRK07726
1415784012927	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1415784012928	active site
1415784012929	putative interdomain interaction site [polypeptide binding]; other site
1415784012930	putative metal-binding site [ion binding]; other site
1415784012931	putative nucleotide binding site [chemical binding]; other site
1415784012932	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1415784012933	domain I; other site
1415784012934	DNA binding groove [nucleotide binding]
1415784012935	phosphate binding site [ion binding]; other site
1415784012936	domain II; other site
1415784012937	domain III; other site
1415784012938	nucleotide binding site [chemical binding]; other site
1415784012939	catalytic site [active]
1415784012940	domain IV; other site
1415784012941	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1415784012942	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
1415784012943	Predicted membrane protein [Function unknown]; Region: COG2364
1415784012944	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1415784012945	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1415784012946	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1415784012947	dimerization interface [polypeptide binding]; other site
1415784012948	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
1415784012949	Sodium Bile acid symporter family; Region: SBF; cl17470
1415784012950	azoreductase; Provisional; Region: PRK13555
1415784012951	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1415784012952	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1415784012953	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
1415784012954	dimer interface [polypeptide binding]; other site
1415784012955	substrate binding site [chemical binding]; other site
1415784012956	metal binding site [ion binding]; metal-binding site
1415784012957	Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372
1415784012958	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
1415784012959	YtkA-like; Region: YtkA; pfam13115
1415784012960	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
1415784012961	EamA-like transporter family; Region: EamA; pfam00892
1415784012962	EamA-like transporter family; Region: EamA; pfam00892
1415784012963	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1415784012964	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1415784012965	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1415784012966	dimerization interface [polypeptide binding]; other site
1415784012967	Rrf2 family protein; Region: rrf2_super; TIGR00738
1415784012968	Transcriptional regulator; Region: Rrf2; pfam02082
1415784012969	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
1415784012970	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
1415784012971	catalytic residues [active]
1415784012972	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
1415784012973	dimer interface [polypeptide binding]; other site
1415784012974	FMN binding site [chemical binding]; other site
1415784012975	amidase; Provisional; Region: PRK06707
1415784012976	Amidase; Region: Amidase; cl11426
1415784012977	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1415784012978	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
1415784012979	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1415784012980	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1415784012981	NAD binding site [chemical binding]; other site
1415784012982	dimer interface [polypeptide binding]; other site
1415784012983	substrate binding site [chemical binding]; other site
1415784012984	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
1415784012985	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1415784012986	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1415784012987	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1415784012988	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1415784012989	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1415784012990	Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328
1415784012991	putative ligand binding site [chemical binding]; other site
1415784012992	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1415784012993	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1415784012994	Walker A/P-loop; other site
1415784012995	ATP binding site [chemical binding]; other site
1415784012996	Q-loop/lid; other site
1415784012997	ABC transporter signature motif; other site
1415784012998	Walker B; other site
1415784012999	D-loop; other site
1415784013000	H-loop/switch region; other site
1415784013001	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1415784013002	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1415784013003	Walker A/P-loop; other site
1415784013004	ATP binding site [chemical binding]; other site
1415784013005	Q-loop/lid; other site
1415784013006	ABC transporter signature motif; other site
1415784013007	Walker B; other site
1415784013008	D-loop; other site
1415784013009	H-loop/switch region; other site
1415784013010	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1415784013011	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1415784013012	TM-ABC transporter signature motif; other site
1415784013013	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1415784013014	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1415784013015	TM-ABC transporter signature motif; other site
1415784013016	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1415784013017	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1415784013018	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1415784013019	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1415784013020	putative Zn2+ binding site [ion binding]; other site
1415784013021	putative DNA binding site [nucleotide binding]; other site
1415784013022	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1415784013023	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
1415784013024	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
1415784013025	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
1415784013026	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1415784013027	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1415784013028	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1415784013029	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1415784013030	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
1415784013031	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1415784013032	Walker A/P-loop; other site
1415784013033	ATP binding site [chemical binding]; other site
1415784013034	Q-loop/lid; other site
1415784013035	ABC transporter signature motif; other site
1415784013036	Walker B; other site
1415784013037	D-loop; other site
1415784013038	H-loop/switch region; other site
1415784013039	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
1415784013040	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1415784013041	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
1415784013042	Walker A/P-loop; other site
1415784013043	ATP binding site [chemical binding]; other site
1415784013044	Q-loop/lid; other site
1415784013045	ABC transporter signature motif; other site
1415784013046	Walker B; other site
1415784013047	D-loop; other site
1415784013048	H-loop/switch region; other site
1415784013049	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1415784013050	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
1415784013051	active site
1415784013052	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1415784013053	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1415784013054	active site
1415784013055	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784013056	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1415784013057	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
1415784013058	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972
1415784013059	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
1415784013060	putative dimer interface [polypeptide binding]; other site
1415784013061	catalytic triad [active]
1415784013062	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1415784013063	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1415784013064	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
1415784013065	dimer interface [polypeptide binding]; other site
1415784013066	FMN binding site [chemical binding]; other site
1415784013067	Bacterial SH3 domain; Region: SH3_3; pfam08239
1415784013068	Bacterial SH3 domain; Region: SH3_3; pfam08239
1415784013069	Bacterial SH3 domain; Region: SH3_3; pfam08239
1415784013070	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1415784013071	NlpC/P60 family; Region: NLPC_P60; pfam00877
1415784013072	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1415784013073	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1415784013074	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1415784013075	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1415784013076	Walker A/P-loop; other site
1415784013077	ATP binding site [chemical binding]; other site
1415784013078	Q-loop/lid; other site
1415784013079	ABC transporter signature motif; other site
1415784013080	Walker B; other site
1415784013081	D-loop; other site
1415784013082	H-loop/switch region; other site
1415784013083	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1415784013084	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784013085	active site
1415784013086	phosphorylation site [posttranslational modification]
1415784013087	intermolecular recognition site; other site
1415784013088	dimerization interface [polypeptide binding]; other site
1415784013089	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1415784013090	DNA binding site [nucleotide binding]
1415784013091	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1415784013092	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1415784013093	dimerization interface [polypeptide binding]; other site
1415784013094	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1415784013095	dimer interface [polypeptide binding]; other site
1415784013096	phosphorylation site [posttranslational modification]
1415784013097	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784013098	ATP binding site [chemical binding]; other site
1415784013099	Mg2+ binding site [ion binding]; other site
1415784013100	G-X-G motif; other site
1415784013101	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666
1415784013102	classical (c) SDRs; Region: SDR_c; cd05233
1415784013103	NAD(P) binding site [chemical binding]; other site
1415784013104	active site
1415784013105	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1415784013106	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784013107	S-adenosylmethionine binding site [chemical binding]; other site
1415784013108	Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439
1415784013109	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1415784013110	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
1415784013111	NodB motif; other site
1415784013112	active site
1415784013113	catalytic site [active]
1415784013114	metal binding site [ion binding]; metal-binding site
1415784013115	SdpI/YhfL protein family; Region: SdpI; pfam13630
1415784013116	isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150
1415784013117	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1415784013118	nudix motif; other site
1415784013119	PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025
1415784013120	homoserine dehydrogenase; Provisional; Region: PRK06349
1415784013121	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1415784013122	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1415784013123	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
1415784013124	threonine synthase; Reviewed; Region: PRK06721
1415784013125	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
1415784013126	homodimer interface [polypeptide binding]; other site
1415784013127	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784013128	catalytic residue [active]
1415784013129	homoserine kinase; Provisional; Region: PRK01212
1415784013130	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1415784013131	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1415784013132	Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308
1415784013133	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
1415784013134	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1415784013135	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784013136	active site
1415784013137	phosphorylation site [posttranslational modification]
1415784013138	intermolecular recognition site; other site
1415784013139	dimerization interface [polypeptide binding]; other site
1415784013140	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1415784013141	DNA binding site [nucleotide binding]
1415784013142	HAMP domain; Region: HAMP; pfam00672
1415784013143	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1415784013144	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1415784013145	dimer interface [polypeptide binding]; other site
1415784013146	phosphorylation site [posttranslational modification]
1415784013147	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784013148	ATP binding site [chemical binding]; other site
1415784013149	Mg2+ binding site [ion binding]; other site
1415784013150	G-X-G motif; other site
1415784013151	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1415784013152	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
1415784013153	NodB motif; other site
1415784013154	active site
1415784013155	catalytic site [active]
1415784013156	Zn binding site [ion binding]; other site
1415784013157	Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368
1415784013158	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
1415784013159	MgtC family; Region: MgtC; pfam02308
1415784013160	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1415784013161	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784013162	Coenzyme A binding pocket [chemical binding]; other site
1415784013163	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1415784013164	IucA / IucC family; Region: IucA_IucC; pfam04183
1415784013165	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1415784013166	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1415784013167	IucA / IucC family; Region: IucA_IucC; pfam04183
1415784013168	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1415784013169	acyl-CoA synthetase; Validated; Region: PRK08308
1415784013170	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1415784013171	acyl-activating enzyme (AAE) consensus motif; other site
1415784013172	AMP binding site [chemical binding]; other site
1415784013173	active site
1415784013174	CoA binding site [chemical binding]; other site
1415784013175	acyl carrier protein; Provisional; Region: PRK07639
1415784013176	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1415784013177	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1415784013178	Metal-binding active site; metal-binding site
1415784013179	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
1415784013180	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784013181	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1415784013182	putative substrate translocation pore; other site
1415784013183	Lysine efflux permease [General function prediction only]; Region: COG1279
1415784013184	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1415784013185	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1415784013186	DNA-binding site [nucleotide binding]; DNA binding site
1415784013187	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1415784013188	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784013189	homodimer interface [polypeptide binding]; other site
1415784013190	catalytic residue [active]
1415784013191	Protein of unknown function (DUF3933); Region: DUF3933; pfam13069
1415784013192	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1415784013193	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
1415784013194	active site
1415784013195	nucleophile elbow; other site
1415784013196	Domain of unknown function (DUF1963); Region: DUF1963; pfam09234
1415784013197	Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279
1415784013198	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1415784013199	Domain of unknown function (DUF4083); Region: DUF4083; pfam13314
1415784013200	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
1415784013201	nudix motif; other site
1415784013202	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
1415784013203	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1415784013204	homodimer interface [polypeptide binding]; other site
1415784013205	NAD binding pocket [chemical binding]; other site
1415784013206	ATP binding pocket [chemical binding]; other site
1415784013207	Mg binding site [ion binding]; other site
1415784013208	active-site loop [active]
1415784013209	FtsX-like permease family; Region: FtsX; pfam02687
1415784013210	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
1415784013211	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
1415784013212	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
1415784013213	active site
1415784013214	catalytic residues [active]
1415784013215	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1415784013216	dimerization interface [polypeptide binding]; other site
1415784013217	putative DNA binding site [nucleotide binding]; other site
1415784013218	putative Zn2+ binding site [ion binding]; other site
1415784013219	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1415784013220	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1415784013221	active site
1415784013222	catalytic tetrad [active]
1415784013223	Protein of unknown function (DUF4257); Region: DUF4257; pfam14074
1415784013224	Protein of unknown function (DUF664); Region: DUF664; pfam04978
1415784013225	DinB superfamily; Region: DinB_2; pfam12867
1415784013226	GTPase RsgA; Reviewed; Region: PRK01889
1415784013227	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1415784013228	RNA binding site [nucleotide binding]; other site
1415784013229	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1415784013230	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1415784013231	GTP/Mg2+ binding site [chemical binding]; other site
1415784013232	G4 box; other site
1415784013233	G5 box; other site
1415784013234	G1 box; other site
1415784013235	Switch I region; other site
1415784013236	G2 box; other site
1415784013237	G3 box; other site
1415784013238	Switch II region; other site
1415784013239	Tar ligand binding domain homologue; Region: TarH; pfam02203
1415784013240	Cache domain; Region: Cache_1; pfam02743
1415784013241	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1415784013242	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1415784013243	dimerization interface [polypeptide binding]; other site
1415784013244	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1415784013245	dimer interface [polypeptide binding]; other site
1415784013246	putative CheW interface [polypeptide binding]; other site
1415784013247	Protein of unknown function (DUF3979); Region: DUF3979; pfam13141
1415784013248	Uncharacterized membrane protein [Function unknown]; Region: COG3949
1415784013249	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1415784013250	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1415784013251	dimerization interface [polypeptide binding]; other site
1415784013252	DPS ferroxidase diiron center [ion binding]; other site
1415784013253	ion pore; other site
1415784013254	Protein of unknown function (DUF3939); Region: DUF3939; pfam13075
1415784013255	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1415784013256	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1415784013257	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1415784013258	Protein of unknown function (DUF3896); Region: DUF3896; pfam13035
1415784013259	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
1415784013260	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1415784013261	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1415784013262	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1415784013263	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1415784013264	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1415784013265	active site
1415784013266	catalytic tetrad [active]
1415784013267	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1415784013268	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
1415784013269	P-loop, Walker A motif; other site
1415784013270	Base recognition motif; other site
1415784013271	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1415784013272	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1415784013273	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784013274	Coenzyme A binding pocket [chemical binding]; other site
1415784013275	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
1415784013276	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1415784013277	metal binding site [ion binding]; metal-binding site
1415784013278	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
1415784013279	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1415784013280	NAD binding site [chemical binding]; other site
1415784013281	active site
1415784013282	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1415784013283	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
1415784013284	active site
1415784013285	FMN binding site [chemical binding]; other site
1415784013286	substrate binding site [chemical binding]; other site
1415784013287	homotetramer interface [polypeptide binding]; other site
1415784013288	catalytic residue [active]
1415784013289	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
1415784013290	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1415784013291	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1415784013292	DNA binding site [nucleotide binding]
1415784013293	active site
1415784013294	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
1415784013295	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1415784013296	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1415784013297	peptide binding site [polypeptide binding]; other site
1415784013298	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
1415784013299	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1415784013300	active site
1415784013301	metal binding site [ion binding]; metal-binding site
1415784013302	short chain dehydrogenase; Provisional; Region: PRK08309
1415784013303	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1415784013304	catalytic core [active]
1415784013305	CotH protein; Region: CotH; pfam08757
1415784013306	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
1415784013307	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
1415784013308	nudix motif; other site
1415784013309	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1415784013310	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1415784013311	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1415784013312	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1415784013313	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1415784013314	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
1415784013315	Cl binding site [ion binding]; other site
1415784013316	oligomer interface [polypeptide binding]; other site
1415784013317	Predicted permeases [General function prediction only]; Region: COG0701
1415784013318	Predicted membrane protein [Function unknown]; Region: COG3689
1415784013319	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1415784013320	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
1415784013321	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1415784013322	putative active site [active]
1415784013323	catalytic site [active]
1415784013324	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1415784013325	putative active site [active]
1415784013326	catalytic site [active]
1415784013327	Coat F domain; Region: Coat_F; pfam07875
1415784013328	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
1415784013329	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1415784013330	NAD binding site [chemical binding]; other site
1415784013331	substrate binding site [chemical binding]; other site
1415784013332	putative active site [active]
1415784013333	Protein of unknown function (DUF456); Region: DUF456; pfam04306
1415784013334	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1415784013335	Domain of unknown function DUF21; Region: DUF21; pfam01595
1415784013336	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1415784013337	Transporter associated domain; Region: CorC_HlyC; smart01091
1415784013338	FOG: CBS domain [General function prediction only]; Region: COG0517
1415784013339	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1415784013340	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1415784013341	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
1415784013342	dimer interface [polypeptide binding]; other site
1415784013343	putative tRNA-binding site [nucleotide binding]; other site
1415784013344	Protein of unknown function (DUF1572); Region: DUF1572; pfam07609
1415784013345	DinB superfamily; Region: DinB_2; pfam12867
1415784013346	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
1415784013347	stage II sporulation protein P; Region: spore_II_P; TIGR02867
1415784013348	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1415784013349	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784013350	Coenzyme A binding pocket [chemical binding]; other site
1415784013351	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
1415784013352	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1415784013353	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1415784013354	nudix motif; other site
1415784013355	amidase; Provisional; Region: PRK06828
1415784013356	Amidase; Region: Amidase; pfam01425
1415784013357	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784013358	putative substrate translocation pore; other site
1415784013359	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
1415784013360	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1415784013361	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
1415784013362	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
1415784013363	stage II sporulation protein P; Region: spore_II_P; TIGR02867
1415784013364	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1415784013365	catalytic core [active]
1415784013366	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1415784013367	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1415784013368	active site
1415784013369	motif I; other site
1415784013370	motif II; other site
1415784013371	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1415784013372	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1415784013373	MarR family; Region: MarR; pfam01047
1415784013374	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784013375	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1415784013376	putative substrate translocation pore; other site
1415784013377	DinB superfamily; Region: DinB_2; pfam12867
1415784013378	DinB family; Region: DinB; cl17821
1415784013379	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1415784013380	alanine racemase; Reviewed; Region: alr; PRK00053
1415784013381	active site
1415784013382	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1415784013383	dimer interface [polypeptide binding]; other site
1415784013384	substrate binding site [chemical binding]; other site
1415784013385	catalytic residues [active]
1415784013386	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784013387	Coenzyme A binding pocket [chemical binding]; other site
1415784013388	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1415784013389	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784013390	Coenzyme A binding pocket [chemical binding]; other site
1415784013391	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1415784013392	glycosyltransferase, MGT family; Region: MGT; TIGR01426
1415784013393	active site
1415784013394	TDP-binding site; other site
1415784013395	acceptor substrate-binding pocket; other site
1415784013396	homodimer interface [polypeptide binding]; other site
1415784013397	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1415784013398	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1415784013399	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1415784013400	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1415784013401	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1415784013402	DNA-binding site [nucleotide binding]; DNA binding site
1415784013403	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1415784013404	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784013405	homodimer interface [polypeptide binding]; other site
1415784013406	catalytic residue [active]
1415784013407	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784013408	Coenzyme A binding pocket [chemical binding]; other site
1415784013409	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1415784013410	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
1415784013411	active site
1415784013412	metal binding site [ion binding]; metal-binding site
1415784013413	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1415784013414	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784013415	Coenzyme A binding pocket [chemical binding]; other site
1415784013416	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
1415784013417	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1415784013418	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784013419	Coenzyme A binding pocket [chemical binding]; other site
1415784013420	Cupin domain; Region: Cupin_2; cl17218
1415784013421	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784013422	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1415784013423	Coenzyme A binding pocket [chemical binding]; other site
1415784013424	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
1415784013425	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1415784013426	type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929
1415784013427	WXG100 protein secretion system (Wss), protein EssA; Region: EssA; pfam10661
1415784013428	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489
1415784013429	type VII secretion protein EssB; Region: T7_EssB; TIGR03926
1415784013430	WXG100 protein secretion system (Wss), protein YukC; Region: YukC; pfam10140
1415784013431	DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538
1415784013432	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
1415784013433	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1415784013434	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1415784013435	Domain of unknown function (DUF3952); Region: DUF3952; pfam13130
1415784013436	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
1415784013437	nucleophilic elbow; other site
1415784013438	catalytic triad; other site
1415784013439	Domain of unknown function (DUF4176); Region: DUF4176; pfam13780
1415784013440	Domain of unknown function (DUF3952); Region: DUF3952; pfam13130
1415784013441	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1415784013442	Coenzyme A binding pocket [chemical binding]; other site
1415784013443	Helix-turn-helix domain; Region: HTH_36; pfam13730
1415784013444	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
1415784013445	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1415784013446	active site
1415784013447	DNA binding site [nucleotide binding]
1415784013448	Int/Topo IB signature motif; other site
1415784013449	Predicted acetyltransferase [General function prediction only]; Region: COG3393
1415784013450	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
1415784013451	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1415784013452	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784013453	S-adenosylmethionine binding site [chemical binding]; other site
1415784013454	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
1415784013455	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
1415784013456	Potassium binding sites [ion binding]; other site
1415784013457	Cesium cation binding sites [ion binding]; other site
1415784013458	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1415784013459	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1415784013460	ATP binding site [chemical binding]; other site
1415784013461	putative Mg++ binding site [ion binding]; other site
1415784013462	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1415784013463	nucleotide binding region [chemical binding]; other site
1415784013464	ATP-binding site [chemical binding]; other site
1415784013465	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1415784013466	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
1415784013467	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1415784013468	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
1415784013469	NADP binding site [chemical binding]; other site
1415784013470	dimer interface [polypeptide binding]; other site
1415784013471	RNA polymerase sigma factor; Provisional; Region: PRK12543
1415784013472	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1415784013473	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1415784013474	DNA binding residues [nucleotide binding]
1415784013475	Domain of unknown function (DUF3600); Region: DUF3600; pfam12207
1415784013476	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1415784013477	Protein of unknown function (DUF3925); Region: DUF3925; pfam13063
1415784013478	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1415784013479	catalytic residues [active]
1415784013480	dimer interface [polypeptide binding]; other site
1415784013481	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1415784013482	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1415784013483	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
1415784013484	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1415784013485	Protein of unknown function DUF58; Region: DUF58; pfam01882
1415784013486	MoxR-like ATPases [General function prediction only]; Region: COG0714
1415784013487	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1415784013488	Walker A motif; other site
1415784013489	ATP binding site [chemical binding]; other site
1415784013490	Walker B motif; other site
1415784013491	arginine finger; other site
1415784013492	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
1415784013493	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
1415784013494	[4Fe-4S] binding site [ion binding]; other site
1415784013495	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1415784013496	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1415784013497	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1415784013498	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
1415784013499	molybdopterin cofactor binding site; other site
1415784013500	nitrate reductase, beta subunit; Region: narH; TIGR01660
1415784013501	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
1415784013502	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
1415784013503	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1415784013504	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1415784013505	ligand binding site [chemical binding]; other site
1415784013506	flexible hinge region; other site
1415784013507	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1415784013508	putative switch regulator; other site
1415784013509	non-specific DNA interactions [nucleotide binding]; other site
1415784013510	DNA binding site [nucleotide binding]
1415784013511	sequence specific DNA binding site [nucleotide binding]; other site
1415784013512	putative cAMP binding site [chemical binding]; other site
1415784013513	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
1415784013514	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1415784013515	FeS/SAM binding site; other site
1415784013516	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1415784013517	thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475
1415784013518	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1415784013519	ATP binding site [chemical binding]; other site
1415784013520	substrate interface [chemical binding]; other site
1415784013521	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1415784013522	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1415784013523	dimer interface [polypeptide binding]; other site
1415784013524	putative functional site; other site
1415784013525	putative MPT binding site; other site
1415784013526	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1415784013527	MoaE homodimer interface [polypeptide binding]; other site
1415784013528	MoaD interaction [polypeptide binding]; other site
1415784013529	active site residues [active]
1415784013530	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1415784013531	MoaE interaction surface [polypeptide binding]; other site
1415784013532	MoeB interaction surface [polypeptide binding]; other site
1415784013533	thiocarboxylated glycine; other site
1415784013534	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
1415784013535	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784013536	putative substrate translocation pore; other site
1415784013537	precorrin-2 dehydrogenase; Validated; Region: PRK06719
1415784013538	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
1415784013539	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
1415784013540	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
1415784013541	putative active site [active]
1415784013542	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
1415784013543	putative active site [active]
1415784013544	bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168
1415784013545	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1415784013546	active site
1415784013547	SAM binding site [chemical binding]; other site
1415784013548	homodimer interface [polypeptide binding]; other site
1415784013549	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1415784013550	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
1415784013551	[2Fe-2S] cluster binding site [ion binding]; other site
1415784013552	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
1415784013553	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1415784013554	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1415784013555	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1415784013556	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1415784013557	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
1415784013558	iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652
1415784013559	Hemerythrin-like domain; Region: Hr-like; cd12108
1415784013560	Protein of unknown function (DUF3954); Region: DUF3954; pfam13128
1415784013561	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
1415784013562	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
1415784013563	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1415784013564	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1415784013565	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1415784013566	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784013567	S-adenosylmethionine binding site [chemical binding]; other site
1415784013568	N-acetyltransferase; Region: Acetyltransf_2; cl00949
1415784013569	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
1415784013570	PGAP1-like protein; Region: PGAP1; pfam07819
1415784013571	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
1415784013572	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1415784013573	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1415784013574	Int/Topo IB signature motif; other site
1415784013575	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1415784013576	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1415784013577	non-specific DNA binding site [nucleotide binding]; other site
1415784013578	salt bridge; other site
1415784013579	sequence-specific DNA binding site [nucleotide binding]; other site
1415784013580	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1415784013581	non-specific DNA binding site [nucleotide binding]; other site
1415784013582	salt bridge; other site
1415784013583	sequence-specific DNA binding site [nucleotide binding]; other site
1415784013584	Helix-turn-helix domain; Region: HTH_17; cl17695
1415784013585	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1415784013586	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1415784013587	non-specific DNA binding site [nucleotide binding]; other site
1415784013588	salt bridge; other site
1415784013589	sequence-specific DNA binding site [nucleotide binding]; other site
1415784013590	DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446
1415784013591	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
1415784013592	YopX protein; Region: YopX; cl09859
1415784013593	Domain of unknown function (DUF4183); Region: DUF4183; pfam13799
1415784013594	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
1415784013595	INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186
1415784013596	Int/Topo IB signature motif; other site
1415784013597	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455
1415784013598	active site
1415784013599	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
1415784013600	Uncharacterized conserved protein [Function unknown]; Region: COG5484
1415784013601	Phage terminase small subunit; Region: Phage_terminase; pfam10668
1415784013602	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1415784013603	Phage terminase large subunit; Region: Terminase_3; cl12054
1415784013604	Phage-related protein [Function unknown]; Region: COG4695; cl01923
1415784013605	phage portal protein, HK97 family; Region: portal_HK97; TIGR01537
1415784013606	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
1415784013607	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
1415784013608	Phage capsid family; Region: Phage_capsid; pfam05065
1415784013609	Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124
1415784013610	Phage-related minor tail protein [Function unknown]; Region: COG5280
1415784013611	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
1415784013612	Phage-related protein [Function unknown]; Region: COG5412
1415784013613	Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; cl02268
1415784013614	Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; cl02268
1415784013615	Holin family; Region: Phage_holin_4; cl01989
1415784013616	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1415784013617	amidase catalytic site [active]
1415784013618	Zn binding residues [ion binding]; other site
1415784013619	substrate binding site [chemical binding]; other site
1415784013620	Bacterial SH3 domain; Region: SH3_3; pfam08239
1415784013621	YolD-like protein; Region: YolD; pfam08863
1415784013622	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
1415784013623	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1415784013624	Multicopper oxidase; Region: Cu-oxidase; pfam00394
1415784013625	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1415784013626	DNA translocase FtsK; Provisional; Region: PRK10263
1415784013627	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
1415784013628	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1415784013629	Zn2+ binding site [ion binding]; other site
1415784013630	Mg2+ binding site [ion binding]; other site
1415784013631	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1415784013632	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1415784013633	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1415784013634	ABC transporter; Region: ABC_tran_2; pfam12848
1415784013635	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1415784013636	Bax inhibitor 1 like; Region: BaxI_1; cl17691
1415784013637	Domain of unknown function (DUF4318); Region: DUF4318; pfam14201
1415784013638	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1415784013639	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1415784013640	dimer interface [polypeptide binding]; other site
1415784013641	ssDNA binding site [nucleotide binding]; other site
1415784013642	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1415784013643	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932
1415784013644	Virulence factor; Region: Virulence_fact; pfam13769
1415784013645	HEAT repeats; Region: HEAT_2; pfam13646
1415784013646	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
1415784013647	Protein of unknown function, DUF393; Region: DUF393; pfam04134
1415784013648	Disulphide isomerase; Region: Disulph_isomer; pfam06491
1415784013649	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
1415784013650	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
1415784013651	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1415784013652	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1415784013653	active site
1415784013654	HIGH motif; other site
1415784013655	KMSK motif region; other site
1415784013656	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
1415784013657	tRNA binding surface [nucleotide binding]; other site
1415784013658	anticodon binding site; other site
1415784013659	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1415784013660	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1415784013661	S-adenosylmethionine binding site [chemical binding]; other site
1415784013662	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1415784013663	binding surface
1415784013664	TPR motif; other site
1415784013665	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
1415784013666	putative active site [active]
1415784013667	TPR repeat; Region: TPR_11; pfam13414
1415784013668	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1415784013669	binding surface
1415784013670	TPR motif; other site
1415784013671	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1415784013672	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1415784013673	binding surface
1415784013674	TPR motif; other site
1415784013675	TPR repeat; Region: TPR_11; pfam13414
1415784013676	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1415784013677	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1415784013678	binding surface
1415784013679	TPR motif; other site
1415784013680	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1415784013681	binding surface
1415784013682	TPR motif; other site
1415784013683	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1415784013684	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1415784013685	binding surface
1415784013686	TPR motif; other site
1415784013687	Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060
1415784013688	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1415784013689	HIGH motif; other site
1415784013690	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1415784013691	active site
1415784013692	KMSKS motif; other site
1415784013693	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
1415784013694	tRNA binding surface [nucleotide binding]; other site
1415784013695	anticodon binding site; other site
1415784013696	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1415784013697	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
1415784013698	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1415784013699	Peptidase M36 family also known as fungalysin family; Region: M36; cd09596
1415784013700	Zn binding site [ion binding]; other site
1415784013701	aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159
1415784013702	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
1415784013703	Dimer interface [polypeptide binding]; other site
1415784013704	anticodon binding site; other site
1415784013705	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
1415784013706	homodimer interface [polypeptide binding]; other site
1415784013707	motif 1; other site
1415784013708	motif 2; other site
1415784013709	active site
1415784013710	motif 3; other site
1415784013711	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
1415784013712	Na2 binding site [ion binding]; other site
1415784013713	putative substrate binding site 1 [chemical binding]; other site
1415784013714	Na binding site 1 [ion binding]; other site
1415784013715	putative substrate binding site 2 [chemical binding]; other site
1415784013716	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1415784013717	Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042
1415784013718	Protein of unknown function (DUF2837); Region: DUF2837; pfam10997
1415784013719	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1415784013720	Eukaryotic phosphomannomutase; Region: PMM; cl17107
1415784013721	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1415784013722	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1415784013723	motif II; other site
1415784013724	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
1415784013725	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1415784013726	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1415784013727	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1415784013728	active site
1415784013729	NAD binding site [chemical binding]; other site
1415784013730	metal binding site [ion binding]; metal-binding site
1415784013731	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
1415784013732	aspartate racemase; Region: asp_race; TIGR00035
1415784013733	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
1415784013734	homodimer interaction site [polypeptide binding]; other site
1415784013735	cofactor binding site; other site
1415784013736	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1415784013737	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1415784013738	hypothetical protein; Validated; Region: PRK06769
1415784013739	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1415784013740	active site
1415784013741	motif I; other site
1415784013742	motif II; other site
1415784013743	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1415784013744	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784013745	Coenzyme A binding pocket [chemical binding]; other site
1415784013746	YpjP-like protein; Region: YpjP; pfam14005
1415784013747	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1415784013748	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1415784013749	motif II; other site
1415784013750	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
1415784013751	putative dimer interface [polypeptide binding]; other site
1415784013752	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1415784013753	ligand binding site [chemical binding]; other site
1415784013754	Zn binding site [ion binding]; other site
1415784013755	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1415784013756	Phosphotransferase enzyme family; Region: APH; pfam01636
1415784013757	active site
1415784013758	ATP binding site [chemical binding]; other site
1415784013759	substrate binding site [chemical binding]; other site
1415784013760	Beta-lactamase; Region: Beta-lactamase; pfam00144
1415784013761	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1415784013762	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
1415784013763	thymidylate synthase; Region: thym_sym; TIGR03284
1415784013764	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1415784013765	dimerization interface [polypeptide binding]; other site
1415784013766	active site
1415784013767	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1415784013768	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1415784013769	folate binding site [chemical binding]; other site
1415784013770	NADP+ binding site [chemical binding]; other site
1415784013771	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
1415784013772	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1415784013773	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
1415784013774	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1415784013775	azoreductase; Reviewed; Region: PRK00170
1415784013776	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1415784013777	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1415784013778	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1415784013779	putative acyl-acceptor binding pocket; other site
1415784013780	Haemolysin-III related; Region: HlyIII; cl03831
1415784013781	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1415784013782	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
1415784013783	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
1415784013784	Protein of unknown function (DUF2535); Region: DUF2535; pfam10751
1415784013785	EDD domain protein, DegV family; Region: DegV; TIGR00762
1415784013786	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1415784013787	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1415784013788	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1415784013789	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
1415784013790	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
1415784013791	Cu(I) binding site [ion binding]; other site
1415784013792	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1415784013793	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1415784013794	putative dimer interface [polypeptide binding]; other site
1415784013795	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
1415784013796	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1415784013797	active site
1415784013798	dimer interface [polypeptide binding]; other site
1415784013799	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1415784013800	Ligand Binding Site [chemical binding]; other site
1415784013801	Molecular Tunnel; other site
1415784013802	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1415784013803	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1415784013804	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1415784013805	active site
1415784013806	metal binding site [ion binding]; metal-binding site
1415784013807	Bacterial SH3 domain; Region: SH3_3; cl17532
1415784013808	Bacterial SH3 domain; Region: SH3_3; cl17532
1415784013809	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1415784013810	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1415784013811	siderophore binding site; other site
1415784013812	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1415784013813	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
1415784013814	homodimer interface [polypeptide binding]; other site
1415784013815	substrate-cofactor binding pocket; other site
1415784013816	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784013817	catalytic residue [active]
1415784013818	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
1415784013819	FMN binding site [chemical binding]; other site
1415784013820	dimer interface [polypeptide binding]; other site
1415784013821	Isochorismatase family; Region: Isochorismatase; pfam00857
1415784013822	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1415784013823	catalytic triad [active]
1415784013824	conserved cis-peptide bond; other site
1415784013825	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
1415784013826	nudix motif; other site
1415784013827	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1415784013828	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1415784013829	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1415784013830	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1415784013831	Histidine kinase; Region: HisKA_3; pfam07730
1415784013832	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784013833	ATP binding site [chemical binding]; other site
1415784013834	Mg2+ binding site [ion binding]; other site
1415784013835	G-X-G motif; other site
1415784013836	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1415784013837	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784013838	active site
1415784013839	phosphorylation site [posttranslational modification]
1415784013840	intermolecular recognition site; other site
1415784013841	dimerization interface [polypeptide binding]; other site
1415784013842	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1415784013843	DNA binding residues [nucleotide binding]
1415784013844	dimerization interface [polypeptide binding]; other site
1415784013845	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1415784013846	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1415784013847	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1415784013848	putative active site [active]
1415784013849	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
1415784013850	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
1415784013851	NAD binding site [chemical binding]; other site
1415784013852	substrate binding site [chemical binding]; other site
1415784013853	catalytic Zn binding site [ion binding]; other site
1415784013854	tetramer interface [polypeptide binding]; other site
1415784013855	structural Zn binding site [ion binding]; other site
1415784013856	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1415784013857	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784013858	dimer interface [polypeptide binding]; other site
1415784013859	conserved gate region; other site
1415784013860	ABC-ATPase subunit interface; other site
1415784013861	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
1415784013862	Beta-lactamase; Region: Beta-lactamase; pfam00144
1415784013863	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1415784013864	Erythromycin esterase; Region: Erythro_esteras; pfam05139
1415784013865	Helix-turn-helix domain; Region: HTH_28; pfam13518
1415784013866	putative transposase OrfB; Reviewed; Region: PHA02517
1415784013867	HTH-like domain; Region: HTH_21; pfam13276
1415784013868	Integrase core domain; Region: rve; pfam00665
1415784013869	Integrase core domain; Region: rve_3; pfam13683
1415784013870	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
1415784013871	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
1415784013872	N- and C-terminal domain interface [polypeptide binding]; other site
1415784013873	active site
1415784013874	catalytic site [active]
1415784013875	metal binding site [ion binding]; metal-binding site
1415784013876	carbohydrate binding site [chemical binding]; other site
1415784013877	ATP binding site [chemical binding]; other site
1415784013878	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1415784013879	GntP family permease; Region: GntP_permease; pfam02447
1415784013880	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490
1415784013881	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1415784013882	Protein of unknown function (DUF2711); Region: DUF2711; pfam10924
1415784013883	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1415784013884	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1415784013885	active site
1415784013886	Predicted flavoprotein [General function prediction only]; Region: COG0431
1415784013887	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1415784013888	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784013889	H+ Antiporter protein; Region: 2A0121; TIGR00900
1415784013890	putative substrate translocation pore; other site
1415784013891	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1415784013892	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1415784013893	putative active site [active]
1415784013894	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1415784013895	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
1415784013896	Walker A/P-loop; other site
1415784013897	ATP binding site [chemical binding]; other site
1415784013898	Q-loop/lid; other site
1415784013899	ABC transporter signature motif; other site
1415784013900	Walker B; other site
1415784013901	D-loop; other site
1415784013902	H-loop/switch region; other site
1415784013903	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784013904	dimer interface [polypeptide binding]; other site
1415784013905	conserved gate region; other site
1415784013906	ABC-ATPase subunit interface; other site
1415784013907	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1415784013908	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
1415784013909	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
1415784013910	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1415784013911	Protein of unknown function (DUF524); Region: DUF524; pfam04411
1415784013912	polar chromosome segregation protein; Reviewed; Region: racA; PRK13182
1415784013913	Helix-turn-helix domain; Region: HTH_17; cl17695
1415784013914	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1415784013915	Domain of unknown function DUF21; Region: DUF21; pfam01595
1415784013916	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1415784013917	Transporter associated domain; Region: CorC_HlyC; smart01091
1415784013918	Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149
1415784013919	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1415784013920	NAD(P) binding site [chemical binding]; other site
1415784013921	catalytic residues [active]
1415784013922	Protein of unknown function (DUF1694); Region: DUF1694; pfam07997
1415784013923	Histidine kinase N terminal; Region: HisK_N; pfam09385
1415784013924	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1415784013925	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1415784013926	dimer interface [polypeptide binding]; other site
1415784013927	phosphorylation site [posttranslational modification]
1415784013928	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784013929	ATP binding site [chemical binding]; other site
1415784013930	Mg2+ binding site [ion binding]; other site
1415784013931	G-X-G motif; other site
1415784013932	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
1415784013933	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
1415784013934	hypothetical protein; Provisional; Region: PRK06917
1415784013935	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1415784013936	inhibitor-cofactor binding pocket; inhibition site
1415784013937	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1415784013938	catalytic residue [active]
1415784013939	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
1415784013940	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
1415784013941	acetylornithine deacetylase; Validated; Region: PRK06915
1415784013942	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895
1415784013943	metal binding site [ion binding]; metal-binding site
1415784013944	dimer interface [polypeptide binding]; other site
1415784013945	putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827
1415784013946	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1415784013947	PAS fold; Region: PAS_4; pfam08448
1415784013948	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1415784013949	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
1415784013950	Walker A motif; other site
1415784013951	ATP binding site [chemical binding]; other site
1415784013952	Walker B motif; other site
1415784013953	arginine finger; other site
1415784013954	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1415784013955	lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820
1415784013956	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1415784013957	FeS/SAM binding site; other site
1415784013958	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
1415784013959	antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870
1415784013960	toxin interface [polypeptide binding]; other site
1415784013961	Zn binding site [ion binding]; other site
1415784013962	hypothetical protein; Provisional; Region: PRK13672
1415784013963	Protein of unknown function (DUF3930); Region: DUF3930; pfam13067
1415784013964	YozD-like protein; Region: YozD; pfam14162
1415784013965	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1415784013966	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1415784013967	active site
1415784013968	ATP binding site [chemical binding]; other site
1415784013969	substrate binding site [chemical binding]; other site
1415784013970	activation loop (A-loop); other site
1415784013971	Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326
1415784013972	SpoOM protein; Region: Spo0M; pfam07070
1415784013973	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1415784013974	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1415784013975	active site
1415784013976	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1415784013977	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
1415784013978	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1415784013979	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1415784013980	DNA binding site [nucleotide binding]
1415784013981	active site
1415784013982	Int/Topo IB signature motif; other site
1415784013983	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1415784013984	active site
1415784013985	metal binding site [ion binding]; metal-binding site
1415784013986	N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123
1415784013987	PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis.  PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b.  Both domains are required for...; Region: GH25_PlyB-like; cd06523
1415784013988	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
1415784013989	active site
1415784013990	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998
1415784013991	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1415784013992	YolD-like protein; Region: YolD; pfam08863
1415784013993	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
1415784013994	acetoacetyl-CoA reductase; Provisional; Region: PRK12824
1415784013995	classical (c) SDRs; Region: SDR_c; cd05233
1415784013996	NAD(P) binding site [chemical binding]; other site
1415784013997	active site
1415784013998	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
1415784013999	Transglycosylase; Region: Transgly; pfam00912
1415784014000	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1415784014001	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1415784014002	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784014003	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1415784014004	putative substrate translocation pore; other site
1415784014005	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118
1415784014006	dimer interface [polypeptide binding]; other site
1415784014007	Citrate synthase; Region: Citrate_synt; pfam00285
1415784014008	active site
1415784014009	coenzyme A binding site [chemical binding]; other site
1415784014010	citrylCoA binding site [chemical binding]; other site
1415784014011	oxalacetate/citrate binding site [chemical binding]; other site
1415784014012	catalytic triad [active]
1415784014013	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
1415784014014	2-methylcitrate dehydratase; Region: prpD; TIGR02330
1415784014015	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1415784014016	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1415784014017	tetramer interface [polypeptide binding]; other site
1415784014018	active site
1415784014019	Mg2+/Mn2+ binding site [ion binding]; other site
1415784014020	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1415784014021	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1415784014022	active site
1415784014023	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1415784014024	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1415784014025	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1415784014026	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
1415784014027	tetrameric interface [polypeptide binding]; other site
1415784014028	NAD binding site [chemical binding]; other site
1415784014029	catalytic residues [active]
1415784014030	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1415784014031	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
1415784014032	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1415784014033	substrate binding site [chemical binding]; other site
1415784014034	oxyanion hole (OAH) forming residues; other site
1415784014035	trimer interface [polypeptide binding]; other site
1415784014036	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
1415784014037	Protein of unknown function (DUF2584); Region: DUF2584; pfam10763
1415784014038	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
1415784014039	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1415784014040	active site
1415784014041	metal binding site [ion binding]; metal-binding site
1415784014042	DNA binding site [nucleotide binding]
1415784014043	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
1415784014044	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
1415784014045	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
1415784014046	Walker A/P-loop; other site
1415784014047	ATP binding site [chemical binding]; other site
1415784014048	Q-loop/lid; other site
1415784014049	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
1415784014050	ABC transporter signature motif; other site
1415784014051	Walker B; other site
1415784014052	D-loop; other site
1415784014053	H-loop/switch region; other site
1415784014054	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1415784014055	dimerization interface [polypeptide binding]; other site
1415784014056	putative DNA binding site [nucleotide binding]; other site
1415784014057	putative Zn2+ binding site [ion binding]; other site
1415784014058	Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556
1415784014059	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
1415784014060	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784014061	putative substrate translocation pore; other site
1415784014062	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
1415784014063	2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331
1415784014064	putative NAD(P) binding site [chemical binding]; other site
1415784014065	active site
1415784014066	isochorismate synthase DhbC; Validated; Region: PRK06923
1415784014067	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1415784014068	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
1415784014069	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
1415784014070	acyl-activating enzyme (AAE) consensus motif; other site
1415784014071	active site
1415784014072	AMP binding site [chemical binding]; other site
1415784014073	substrate binding site [chemical binding]; other site
1415784014074	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
1415784014075	hydrophobic substrate binding pocket; other site
1415784014076	Isochorismatase family; Region: Isochorismatase; pfam00857
1415784014077	active site
1415784014078	conserved cis-peptide bond; other site
1415784014079	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
1415784014080	Condensation domain; Region: Condensation; pfam00668
1415784014081	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
1415784014082	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1415784014083	acyl-activating enzyme (AAE) consensus motif; other site
1415784014084	AMP binding site [chemical binding]; other site
1415784014085	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1415784014086	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
1415784014087	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1415784014088	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1415784014089	acyl-activating enzyme (AAE) consensus motif; other site
1415784014090	AMP binding site [chemical binding]; other site
1415784014091	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1415784014092	MbtH-like protein; Region: MbtH; pfam03621
1415784014093	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1415784014094	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1415784014095	putative substrate translocation pore; other site
1415784014096	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
1415784014097	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1415784014098	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1415784014099	IHF dimer interface [polypeptide binding]; other site
1415784014100	IHF - DNA interface [nucleotide binding]; other site
1415784014101	Protein of unknown function (DUF3891); Region: DUF3891; pfam13030
1415784014102	DinB family; Region: DinB; cl17821
1415784014103	DinB superfamily; Region: DinB_2; pfam12867
1415784014104	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
1415784014105	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
1415784014106	active site
1415784014107	catalytic triad [active]
1415784014108	Domain of unknown function (DUF3994); Region: DUF3994; pfam13159
1415784014109	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1415784014110	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
1415784014111	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1415784014112	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1415784014113	RNA binding surface [nucleotide binding]; other site
1415784014114	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
1415784014115	probable active site [active]
1415784014116	threonyl-tRNA synthetase; Reviewed; Region: PRK12444
1415784014117	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1415784014118	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1415784014119	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1415784014120	active site
1415784014121	dimer interface [polypeptide binding]; other site
1415784014122	motif 1; other site
1415784014123	motif 2; other site
1415784014124	motif 3; other site
1415784014125	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1415784014126	anticodon binding site; other site
1415784014127	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1415784014128	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1415784014129	Walker A/P-loop; other site
1415784014130	ATP binding site [chemical binding]; other site
1415784014131	Q-loop/lid; other site
1415784014132	ABC transporter signature motif; other site
1415784014133	Walker B; other site
1415784014134	D-loop; other site
1415784014135	H-loop/switch region; other site
1415784014136	FtsX-like permease family; Region: FtsX; pfam02687
1415784014137	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1415784014138	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
1415784014139	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1415784014140	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1415784014141	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1415784014142	ABC-ATPase subunit interface; other site
1415784014143	pyruvate oxidase; Provisional; Region: PRK08611
1415784014144	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1415784014145	PYR/PP interface [polypeptide binding]; other site
1415784014146	dimer interface [polypeptide binding]; other site
1415784014147	tetramer interface [polypeptide binding]; other site
1415784014148	TPP binding site [chemical binding]; other site
1415784014149	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1415784014150	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1415784014151	TPP-binding site [chemical binding]; other site
1415784014152	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
1415784014153	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1415784014154	nuc_hydro_ TvIAG:  Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax.   Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647
1415784014155	active site
1415784014156	dimerization interface [polypeptide binding]; other site
1415784014157	Protein of unknown function (DUF2441); Region: DUF2441; pfam10386
1415784014158	Protein of unknown function, DUF606; Region: DUF606; pfam04657
1415784014159	DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402
1415784014160	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1415784014161	ligand binding site [chemical binding]; other site
1415784014162	flexible hinge region; other site
1415784014163	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
1415784014164	Protein of unknown function, DUF606; Region: DUF606; pfam04657
1415784014165	YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094
1415784014166	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1415784014167	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1415784014168	Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791
1415784014169	Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791
1415784014170	Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791
1415784014171	Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791
1415784014172	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1415784014173	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
1415784014174	catalytic triad [active]
1415784014175	catalytic triad [active]
1415784014176	oxyanion hole [active]
1415784014177	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1415784014178	PAS domain S-box; Region: sensory_box; TIGR00229
1415784014179	PAS domain S-box; Region: sensory_box; TIGR00229
1415784014180	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1415784014181	putative active site [active]
1415784014182	heme pocket [chemical binding]; other site
1415784014183	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1415784014184	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1415784014185	putative active site [active]
1415784014186	heme pocket [chemical binding]; other site
1415784014187	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1415784014188	dimer interface [polypeptide binding]; other site
1415784014189	phosphorylation site [posttranslational modification]
1415784014190	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784014191	ATP binding site [chemical binding]; other site
1415784014192	Mg2+ binding site [ion binding]; other site
1415784014193	G-X-G motif; other site
1415784014194	Clostridial binary toxin B/anthrax toxin PA; Region: Binary_toxB; pfam03495
1415784014195	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1415784014196	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1415784014197	active site
1415784014198	phosphorylation site [posttranslational modification]
1415784014199	intermolecular recognition site; other site
1415784014200	dimerization interface [polypeptide binding]; other site
1415784014201	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1415784014202	DNA binding site [nucleotide binding]
1415784014203	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1415784014204	HAMP domain; Region: HAMP; pfam00672
1415784014205	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1415784014206	dimer interface [polypeptide binding]; other site
1415784014207	phosphorylation site [posttranslational modification]
1415784014208	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1415784014209	ATP binding site [chemical binding]; other site
1415784014210	Mg2+ binding site [ion binding]; other site
1415784014211	G-X-G motif; other site
1415784014212	Electron transfer DM13; Region: DM13; pfam10517
1415784014213	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1415784014214	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
1415784014215	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1415784014216	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1415784014217	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1415784014218	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1415784014219	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1415784014220	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1415784014221	MMPL family; Region: MMPL; pfam03176
1415784014222	MMPL family; Region: MMPL; pfam03176
1415784014223	Protein of unknown function (DUF4021); Region: DUF4021; pfam13213
1415784014224	Chloramphenicol acetyltransferase; Region: CAT; cl02008
1415784014225	Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845
1415784014226	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1415784014227	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784014228	Coenzyme A binding pocket [chemical binding]; other site
1415784014229	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1415784014230	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1415784014231	putative acetyltransferase YhhY; Provisional; Region: PRK10140
1415784014232	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1415784014233	Coenzyme A binding pocket [chemical binding]; other site
1415784014234	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1415784014235	EamA-like transporter family; Region: EamA; pfam00892
1415784014236	EamA-like transporter family; Region: EamA; pfam00892
1415784014237	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1415784014238	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
1415784014239	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1415784014240	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1415784014241	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1415784014242	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1415784014243	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1415784014244	DNA-binding site [nucleotide binding]; DNA binding site
1415784014245	RNA-binding motif; other site
1415784014246	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
1415784014247	dinuclear metal binding motif [ion binding]; other site
1415784014248	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
1415784014249	dinuclear metal binding motif [ion binding]; other site
1415784014250	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
1415784014251	Protein of unknown function (DUF2642); Region: DUF2642; pfam10842
1415784014252	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142
1415784014253	RNAase interaction site [polypeptide binding]; other site
1415784014254	Bacterial SH3 domain; Region: SH3_3; pfam08239
1415784014255	A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449
1415784014256	microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th,  Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212
1415784014257	active site
1415784014258	Bacterial SH3 domain; Region: SH3_3; cl17532
1415784014259	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1415784014260	active site
1415784014261	DNA binding site [nucleotide binding]
1415784014262	Int/Topo IB signature motif; other site
1415784014263	hypothetical protein; Provisional; Region: PRK06762
1415784014264	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1415784014265	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1415784014266	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1415784014267	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1415784014268	catalytic residues [active]
1415784014269	catalytic nucleophile [active]
1415784014270	Presynaptic Site I dimer interface [polypeptide binding]; other site
1415784014271	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1415784014272	Synaptic Flat tetramer interface [polypeptide binding]; other site
1415784014273	Synaptic Site I dimer interface [polypeptide binding]; other site
1415784014274	DNA binding site [nucleotide binding]
1415784014275	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
1415784014276	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
1415784014277	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1415784014278	Walker A/P-loop; other site
1415784014279	ATP binding site [chemical binding]; other site
1415784014280	Q-loop/lid; other site
1415784014281	ABC transporter signature motif; other site
1415784014282	Walker B; other site
1415784014283	D-loop; other site
1415784014284	H-loop/switch region; other site
1415784014285	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
1415784014286	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1415784014287	classical (c) SDRs; Region: SDR_c; cd05233
1415784014288	NAD(P) binding site [chemical binding]; other site
1415784014289	active site
1415784014290	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1415784014291	transaminase, acetylornithine/succinylornithine family; Region: argD; TIGR00707
1415784014292	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1415784014293	catalytic residue [active]
1415784014294	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1415784014295	Methyltransferase domain; Region: Methyltransf_25; pfam13649
1415784014296	S-adenosylmethionine binding site [chemical binding]; other site
1415784014297	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709
1415784014298	Peptidase family M50; Region: Peptidase_M50; pfam02163
1415784014299	active site
1415784014300	putative substrate binding region [chemical binding]; other site
1415784014301	putative transposase OrfB; Reviewed; Region: PHA02517
1415784014302	HTH-like domain; Region: HTH_21; pfam13276
1415784014303	Integrase core domain; Region: rve; pfam00665
1415784014304	Integrase core domain; Region: rve_3; pfam13683
1415784014305	Helix-turn-helix domain; Region: HTH_28; pfam13518
1415784014306	Winged helix-turn helix; Region: HTH_29; pfam13551
1415784014307	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
1415784014308	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
1415784014309	conjugal transfer protein TrbE; Provisional; Region: PRK13830
1415784014310	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
1415784014311	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1415784014312	Peptidase family M23; Region: Peptidase_M23; pfam01551
1415784014313	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
1415784014314	Domain of unknown function (DUF4122); Region: DUF4122; pfam13498
1415784014315	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1415784014316	AAA-like domain; Region: AAA_10; pfam12846
1415784014317	Walker A motif; other site
1415784014318	ATP binding site [chemical binding]; other site
1415784014319	TcpE family; Region: TcpE; pfam12648
1415784014320	Conjugative transposon protein TcpC; Region: TpcC; pfam12642
1415784014321	Replication-relaxation; Region: Replic_Relax; pfam13814
1415784014322	AAA-like domain; Region: AAA_10; pfam12846
1415784014323	TQXA domain; Region: TQXA_dom; TIGR03934
1415784014324	Cna protein B-type domain; Region: Cna_B; pfam05738
1415784014325	Cna protein B-type domain; Region: Cna_B; pfam05738
1415784014326	Cna protein B-type domain; Region: Cna_B; pfam05738
1415784014327	Cna protein B-type domain; Region: Cna_B; pfam05738
1415784014328	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1415784014329	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1415784014330	non-specific DNA binding site [nucleotide binding]; other site
1415784014331	salt bridge; other site
1415784014332	sequence-specific DNA binding site [nucleotide binding]; other site
1415784014333	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1415784014334	sequence-specific DNA binding site [nucleotide binding]; other site
1415784014335	salt bridge; other site
1415784014336	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
1415784014337	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1415784014338	active site
1415784014339	catalytic residues [active]
1415784014340	DNA binding site [nucleotide binding]
1415784014341	Int/Topo IB signature motif; other site
1415784014342	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1415784014343	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1415784014344	non-specific DNA binding site [nucleotide binding]; other site
1415784014345	salt bridge; other site
1415784014346	sequence-specific DNA binding site [nucleotide binding]; other site
1415784014347	CAAX protease self-immunity; Region: Abi; pfam02517
1415784014348	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1415784014349	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1415784014350	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1415784014351	active site
1415784014352	motif I; other site
1415784014353	motif II; other site
1415784014354	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1415784014355	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
1415784014356	putative protofilament interface [polypeptide binding]; other site
1415784014357	nucleotide binding site [chemical binding]; other site
1415784014358	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
1415784014359	putative active site [active]
1415784014360	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
1415784014361	Replication-relaxation; Region: Replic_Relax; pfam13814
1415784014362	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1415784014363	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1415784014364	bacterial Hfq-like; Region: Hfq; cd01716
1415784014365	hexamer interface [polypeptide binding]; other site
1415784014366	Sm1 motif; other site
1415784014367	RNA binding site [nucleotide binding]; other site
1415784014368	Sm2 motif; other site
1415784014369	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
1415784014370	Baculovirus E66 occlusion-derived virus envelope protein; Region: Baculo_E66; cl17813
1415784014371	Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040
1415784014372	YueH-like protein; Region: YueH; pfam14166
1415784014373	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1415784014374	active site
1415784014375	DNA binding site [nucleotide binding]
1415784014376	Int/Topo IB signature motif; other site
1415784014377	Protein of unknown function (DUF3967); Region: DUF3967; pfam13152
1415784014378	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1415784014379	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1415784014380	non-specific DNA binding site [nucleotide binding]; other site
1415784014381	salt bridge; other site
1415784014382	sequence-specific DNA binding site [nucleotide binding]; other site
1415784014383	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1415784014384	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076