-- dump date 20140618_225709 -- class Genbank::misc_feature -- table misc_feature_note -- id note 412694000001 Phage terminase small subunit; Region: Phage_terminase; pfam10668 412694000002 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 412694000003 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 412694000004 GIY-YIG motif/motif A; other site 412694000005 active site 412694000006 catalytic site [active] 412694000007 metal binding site [ion binding]; metal-binding site 412694000008 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 412694000009 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 412694000010 catalytic residues [active] 412694000011 catalytic nucleophile [active] 412694000012 Presynaptic Site I dimer interface [polypeptide binding]; other site 412694000013 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 412694000014 Synaptic Flat tetramer interface [polypeptide binding]; other site 412694000015 Synaptic Site I dimer interface [polypeptide binding]; other site 412694000016 DNA binding site [nucleotide binding] 412694000017 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 412694000018 DNA-binding interface [nucleotide binding]; DNA binding site 412694000019 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 412694000020 Recombination protein U; Region: RecU; pfam03838 412694000021 dUTPase; Region: dUTPase_2; pfam08761 412694000022 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 412694000023 active site 412694000024 homodimer interface [polypeptide binding]; other site 412694000025 metal binding site [ion binding]; metal-binding site 412694000026 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 412694000027 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 412694000028 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 412694000029 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412694000030 Walker A motif; other site 412694000031 ATP binding site [chemical binding]; other site 412694000032 Walker B motif; other site 412694000033 arginine finger; other site 412694000034 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 412694000035 ERF superfamily; Region: ERF; pfam04404 412694000036 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 412694000037 Prophage antirepressor [Transcription]; Region: COG3617 412694000038 BRO family, N-terminal domain; Region: Bro-N; smart01040 412694000039 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 412694000040 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412694000041 non-specific DNA binding site [nucleotide binding]; other site 412694000042 salt bridge; other site 412694000043 sequence-specific DNA binding site [nucleotide binding]; other site 412694000044 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412694000045 non-specific DNA binding site [nucleotide binding]; other site 412694000046 salt bridge; other site 412694000047 sequence-specific DNA binding site [nucleotide binding]; other site 412694000048 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 412694000049 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412694000050 non-specific DNA binding site [nucleotide binding]; other site 412694000051 salt bridge; other site 412694000052 sequence-specific DNA binding site [nucleotide binding]; other site 412694000053 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 412694000054 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 412694000055 Protein of unknown function (DUF1052); Region: DUF1052; cl02197 412694000056 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 412694000057 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 412694000058 P-loop; other site 412694000059 Magnesium ion binding site [ion binding]; other site 412694000060 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 412694000061 Magnesium ion binding site [ion binding]; other site 412694000062 Uncharacterized conserved protein [Function unknown]; Region: COG5276 412694000063 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 412694000064 putative catalytic site [active] 412694000065 putative metal binding site [ion binding]; other site 412694000066 putative phosphate binding site [ion binding]; other site 412694000067 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 412694000068 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 412694000069 DNA binding residues [nucleotide binding] 412694000070 DNA polymerase IV; Reviewed; Region: PRK03103 412694000071 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 412694000072 active site 412694000073 DNA binding site [nucleotide binding] 412694000074 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 412694000075 YolD-like protein; Region: YolD; pfam08863 412694000076 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 412694000077 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 412694000078 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 412694000079 active site 412694000080 metal binding site [ion binding]; metal-binding site 412694000081 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 412694000082 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 412694000083 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 412694000084 Phage tail protein; Region: Sipho_tail; pfam05709 412694000085 Phage-related protein [Function unknown]; Region: COG5412 412694000086 Phage protein; Region: DUF3647; pfam12363 412694000087 Phage major tail protein 2; Region: Phage_tail_2; pfam06199 412694000088 Domain of unknown function (DUF3599); Region: DUF3599; pfam12206 412694000089 Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053 412694000090 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 412694000091 Phage-related protein [Function unknown]; Region: COG4695; cl01923 412694000092 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 412694000093 DnaA N-terminal domain; Region: DnaA_N; pfam11638 412694000094 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412694000095 Walker A motif; other site 412694000096 ATP binding site [chemical binding]; other site 412694000097 Walker B motif; other site 412694000098 arginine finger; other site 412694000099 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 412694000100 DnaA box-binding interface [nucleotide binding]; other site 412694000101 DNA polymerase III subunit beta; Validated; Region: PRK05643 412694000102 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 412694000103 putative DNA binding surface [nucleotide binding]; other site 412694000104 dimer interface [polypeptide binding]; other site 412694000105 beta-clamp/clamp loader binding surface; other site 412694000106 beta-clamp/translesion DNA polymerase binding surface; other site 412694000107 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 412694000108 recombination protein F; Reviewed; Region: recF; PRK00064 412694000109 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 412694000110 Walker A/P-loop; other site 412694000111 ATP binding site [chemical binding]; other site 412694000112 Q-loop/lid; other site 412694000113 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412694000114 ABC transporter signature motif; other site 412694000115 Walker B; other site 412694000116 D-loop; other site 412694000117 H-loop/switch region; other site 412694000118 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 412694000119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694000120 Mg2+ binding site [ion binding]; other site 412694000121 G-X-G motif; other site 412694000122 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 412694000123 anchoring element; other site 412694000124 dimer interface [polypeptide binding]; other site 412694000125 ATP binding site [chemical binding]; other site 412694000126 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 412694000127 active site 412694000128 putative metal-binding site [ion binding]; other site 412694000129 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 412694000130 DNA gyrase subunit A; Validated; Region: PRK05560 412694000131 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 412694000132 CAP-like domain; other site 412694000133 active site 412694000134 primary dimer interface [polypeptide binding]; other site 412694000135 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 412694000136 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 412694000137 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 412694000138 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 412694000139 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 412694000140 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 412694000141 YaaC-like Protein; Region: YaaC; pfam14175 412694000142 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 412694000143 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 412694000144 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 412694000145 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 412694000146 active site 412694000147 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 412694000148 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 412694000149 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 412694000150 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 412694000151 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 412694000152 active site 412694000153 multimer interface [polypeptide binding]; other site 412694000154 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 412694000155 predicted active site [active] 412694000156 catalytic triad [active] 412694000157 seryl-tRNA synthetase; Provisional; Region: PRK05431 412694000158 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 412694000159 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 412694000160 dimer interface [polypeptide binding]; other site 412694000161 active site 412694000162 motif 1; other site 412694000163 motif 2; other site 412694000164 motif 3; other site 412694000165 Domain of unknown function (DUF3797); Region: DUF3797; pfam12677 412694000166 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 412694000167 DNA binding residues [nucleotide binding] 412694000168 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 412694000169 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 412694000170 Substrate-binding site [chemical binding]; other site 412694000171 Substrate specificity [chemical binding]; other site 412694000172 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 412694000173 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 412694000174 Substrate-binding site [chemical binding]; other site 412694000175 Substrate specificity [chemical binding]; other site 412694000176 Isochorismatase family; Region: Isochorismatase; pfam00857 412694000177 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 412694000178 catalytic triad [active] 412694000179 conserved cis-peptide bond; other site 412694000180 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 412694000181 nucleoside/Zn binding site; other site 412694000182 dimer interface [polypeptide binding]; other site 412694000183 catalytic motif [active] 412694000184 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 412694000185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412694000186 Walker A motif; other site 412694000187 ATP binding site [chemical binding]; other site 412694000188 Walker B motif; other site 412694000189 arginine finger; other site 412694000190 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 412694000191 hypothetical protein; Validated; Region: PRK00153 412694000192 recombination protein RecR; Reviewed; Region: recR; PRK00076 412694000193 RecR protein; Region: RecR; pfam02132 412694000194 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 412694000195 putative active site [active] 412694000196 putative metal-binding site [ion binding]; other site 412694000197 tetramer interface [polypeptide binding]; other site 412694000198 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 412694000199 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 412694000200 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 412694000201 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 412694000202 homodimer interface [polypeptide binding]; other site 412694000203 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694000204 catalytic residue [active] 412694000205 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 412694000206 thymidylate kinase; Validated; Region: tmk; PRK00698 412694000207 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 412694000208 TMP-binding site; other site 412694000209 ATP-binding site [chemical binding]; other site 412694000210 DNA polymerase III subunit delta'; Validated; Region: PRK08058 412694000211 DNA polymerase III subunit delta'; Validated; Region: PRK08485 412694000212 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 412694000213 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 412694000214 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 412694000215 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694000216 S-adenosylmethionine binding site [chemical binding]; other site 412694000217 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 412694000218 GIY-YIG motif/motif A; other site 412694000219 putative active site [active] 412694000220 putative metal binding site [ion binding]; other site 412694000221 Predicted methyltransferases [General function prediction only]; Region: COG0313 412694000222 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 412694000223 putative SAM binding site [chemical binding]; other site 412694000224 putative homodimer interface [polypeptide binding]; other site 412694000225 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 412694000226 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 412694000227 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 412694000228 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 412694000229 active site 412694000230 HIGH motif; other site 412694000231 KMSKS motif; other site 412694000232 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 412694000233 tRNA binding surface [nucleotide binding]; other site 412694000234 anticodon binding site; other site 412694000235 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 412694000236 dimer interface [polypeptide binding]; other site 412694000237 putative tRNA-binding site [nucleotide binding]; other site 412694000238 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 412694000239 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 412694000240 active site 412694000241 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 412694000242 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 412694000243 putative active site [active] 412694000244 putative metal binding site [ion binding]; other site 412694000245 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 412694000246 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 412694000247 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694000248 S-adenosylmethionine binding site [chemical binding]; other site 412694000249 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 412694000250 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 412694000251 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 412694000252 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 412694000253 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 412694000254 pur operon repressor; Provisional; Region: PRK09213 412694000255 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 412694000256 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 412694000257 active site 412694000258 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 412694000259 homotrimer interaction site [polypeptide binding]; other site 412694000260 putative active site [active] 412694000261 regulatory protein SpoVG; Reviewed; Region: PRK13259 412694000262 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 412694000263 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 412694000264 Substrate binding site; other site 412694000265 Mg++ binding site; other site 412694000266 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 412694000267 active site 412694000268 substrate binding site [chemical binding]; other site 412694000269 CoA binding site [chemical binding]; other site 412694000270 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 412694000271 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 412694000272 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 412694000273 active site 412694000274 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 412694000275 putative active site [active] 412694000276 catalytic residue [active] 412694000277 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 412694000278 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 412694000279 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 412694000280 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 412694000281 ATP binding site [chemical binding]; other site 412694000282 putative Mg++ binding site [ion binding]; other site 412694000283 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412694000284 nucleotide binding region [chemical binding]; other site 412694000285 ATP-binding site [chemical binding]; other site 412694000286 TRCF domain; Region: TRCF; pfam03461 412694000287 stage V sporulation protein T; Region: spore_V_T; TIGR02851 412694000288 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 412694000289 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 412694000290 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 412694000291 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 412694000292 putative SAM binding site [chemical binding]; other site 412694000293 putative homodimer interface [polypeptide binding]; other site 412694000294 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 412694000295 homodimer interface [polypeptide binding]; other site 412694000296 metal binding site [ion binding]; metal-binding site 412694000297 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 412694000298 homodimer interface [polypeptide binding]; other site 412694000299 active site 412694000300 putative chemical substrate binding site [chemical binding]; other site 412694000301 metal binding site [ion binding]; metal-binding site 412694000302 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 412694000303 RNA binding surface [nucleotide binding]; other site 412694000304 sporulation protein YabP; Region: spore_yabP; TIGR02892 412694000305 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 412694000306 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 412694000307 Septum formation initiator; Region: DivIC; pfam04977 412694000308 hypothetical protein; Provisional; Region: PRK08582 412694000309 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 412694000310 RNA binding site [nucleotide binding]; other site 412694000311 stage II sporulation protein E; Region: spore_II_E; TIGR02865 412694000312 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 412694000313 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 412694000314 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 412694000315 Ligand Binding Site [chemical binding]; other site 412694000316 TilS substrate binding domain; Region: TilS; pfam09179 412694000317 TilS substrate C-terminal domain; Region: TilS_C; smart00977 412694000318 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 412694000319 active site 412694000320 FtsH Extracellular; Region: FtsH_ext; pfam06480 412694000321 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 412694000322 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412694000323 Walker A motif; other site 412694000324 ATP binding site [chemical binding]; other site 412694000325 Walker B motif; other site 412694000326 arginine finger; other site 412694000327 Peptidase family M41; Region: Peptidase_M41; pfam01434 412694000328 pantothenate kinase; Reviewed; Region: PRK13318 412694000329 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 412694000330 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 412694000331 dimerization interface [polypeptide binding]; other site 412694000332 domain crossover interface; other site 412694000333 redox-dependent activation switch; other site 412694000334 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 412694000335 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 412694000336 dimer interface [polypeptide binding]; other site 412694000337 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694000338 catalytic residue [active] 412694000339 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 412694000340 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 412694000341 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 412694000342 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 412694000343 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 412694000344 glutamine binding [chemical binding]; other site 412694000345 catalytic triad [active] 412694000346 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 412694000347 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 412694000348 homodimer interface [polypeptide binding]; other site 412694000349 substrate-cofactor binding pocket; other site 412694000350 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694000351 catalytic residue [active] 412694000352 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 412694000353 dihydropteroate synthase; Region: DHPS; TIGR01496 412694000354 substrate binding pocket [chemical binding]; other site 412694000355 dimer interface [polypeptide binding]; other site 412694000356 inhibitor binding site; inhibition site 412694000357 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 412694000358 homooctamer interface [polypeptide binding]; other site 412694000359 active site 412694000360 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 412694000361 catalytic center binding site [active] 412694000362 ATP binding site [chemical binding]; other site 412694000363 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 412694000364 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412694000365 non-specific DNA binding site [nucleotide binding]; other site 412694000366 salt bridge; other site 412694000367 sequence-specific DNA binding site [nucleotide binding]; other site 412694000368 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 412694000369 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 412694000370 FMN binding site [chemical binding]; other site 412694000371 active site 412694000372 catalytic residues [active] 412694000373 substrate binding site [chemical binding]; other site 412694000374 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 412694000375 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 412694000376 dimer interface [polypeptide binding]; other site 412694000377 putative anticodon binding site; other site 412694000378 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 412694000379 motif 1; other site 412694000380 active site 412694000381 motif 2; other site 412694000382 motif 3; other site 412694000383 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 412694000384 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 412694000385 UvrB/uvrC motif; Region: UVR; pfam02151 412694000386 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 412694000387 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 412694000388 ADP binding site [chemical binding]; other site 412694000389 phosphagen binding site; other site 412694000390 substrate specificity loop; other site 412694000391 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 412694000392 Clp amino terminal domain; Region: Clp_N; pfam02861 412694000393 Clp amino terminal domain; Region: Clp_N; pfam02861 412694000394 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412694000395 Walker A motif; other site 412694000396 ATP binding site [chemical binding]; other site 412694000397 Walker B motif; other site 412694000398 arginine finger; other site 412694000399 UvrB/uvrC motif; Region: UVR; pfam02151 412694000400 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412694000401 Walker A motif; other site 412694000402 ATP binding site [chemical binding]; other site 412694000403 Walker B motif; other site 412694000404 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 412694000405 DNA repair protein RadA; Provisional; Region: PRK11823 412694000406 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 412694000407 Walker A motif/ATP binding site; other site 412694000408 ATP binding site [chemical binding]; other site 412694000409 Walker B motif; other site 412694000410 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 412694000411 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 412694000412 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 412694000413 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 412694000414 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 412694000415 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 412694000416 putative active site [active] 412694000417 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 412694000418 substrate binding site; other site 412694000419 dimer interface; other site 412694000420 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 412694000421 homotrimer interaction site [polypeptide binding]; other site 412694000422 zinc binding site [ion binding]; other site 412694000423 CDP-binding sites; other site 412694000424 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 412694000425 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 412694000426 active site 412694000427 HIGH motif; other site 412694000428 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 412694000429 active site 412694000430 KMSKS motif; other site 412694000431 serine O-acetyltransferase; Region: cysE; TIGR01172 412694000432 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 412694000433 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 412694000434 trimer interface [polypeptide binding]; other site 412694000435 active site 412694000436 substrate binding site [chemical binding]; other site 412694000437 CoA binding site [chemical binding]; other site 412694000438 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 412694000439 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 412694000440 active site 412694000441 HIGH motif; other site 412694000442 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 412694000443 KMSKS motif; other site 412694000444 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 412694000445 tRNA binding surface [nucleotide binding]; other site 412694000446 anticodon binding site; other site 412694000447 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 412694000448 active site 412694000449 metal binding site [ion binding]; metal-binding site 412694000450 dimerization interface [polypeptide binding]; other site 412694000451 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 412694000452 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 412694000453 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 412694000454 YacP-like NYN domain; Region: NYN_YacP; pfam05991 412694000455 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 412694000456 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412694000457 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 412694000458 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 412694000459 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 412694000460 putative homodimer interface [polypeptide binding]; other site 412694000461 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 412694000462 heterodimer interface [polypeptide binding]; other site 412694000463 homodimer interface [polypeptide binding]; other site 412694000464 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 412694000465 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 412694000466 23S rRNA interface [nucleotide binding]; other site 412694000467 L7/L12 interface [polypeptide binding]; other site 412694000468 putative thiostrepton binding site; other site 412694000469 L25 interface [polypeptide binding]; other site 412694000470 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 412694000471 mRNA/rRNA interface [nucleotide binding]; other site 412694000472 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 412694000473 23S rRNA interface [nucleotide binding]; other site 412694000474 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 412694000475 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 412694000476 core dimer interface [polypeptide binding]; other site 412694000477 peripheral dimer interface [polypeptide binding]; other site 412694000478 L10 interface [polypeptide binding]; other site 412694000479 L11 interface [polypeptide binding]; other site 412694000480 putative EF-Tu interaction site [polypeptide binding]; other site 412694000481 putative EF-G interaction site [polypeptide binding]; other site 412694000482 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 412694000483 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694000484 S-adenosylmethionine binding site [chemical binding]; other site 412694000485 DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085 412694000486 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 412694000487 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 412694000488 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 412694000489 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 412694000490 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 412694000491 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 412694000492 RPB10 interaction site [polypeptide binding]; other site 412694000493 RPB1 interaction site [polypeptide binding]; other site 412694000494 RPB11 interaction site [polypeptide binding]; other site 412694000495 RPB3 interaction site [polypeptide binding]; other site 412694000496 RPB12 interaction site [polypeptide binding]; other site 412694000497 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 412694000498 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 412694000499 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 412694000500 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 412694000501 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 412694000502 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 412694000503 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 412694000504 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 412694000505 G-loop; other site 412694000506 DNA binding site [nucleotide binding] 412694000507 hypothetical protein; Provisional; Region: PRK06683 412694000508 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 412694000509 S17 interaction site [polypeptide binding]; other site 412694000510 S8 interaction site; other site 412694000511 16S rRNA interaction site [nucleotide binding]; other site 412694000512 streptomycin interaction site [chemical binding]; other site 412694000513 23S rRNA interaction site [nucleotide binding]; other site 412694000514 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 412694000515 30S ribosomal protein S7; Validated; Region: PRK05302 412694000516 elongation factor G; Reviewed; Region: PRK00007 412694000517 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 412694000518 G1 box; other site 412694000519 putative GEF interaction site [polypeptide binding]; other site 412694000520 GTP/Mg2+ binding site [chemical binding]; other site 412694000521 Switch I region; other site 412694000522 G2 box; other site 412694000523 G3 box; other site 412694000524 Switch II region; other site 412694000525 G4 box; other site 412694000526 G5 box; other site 412694000527 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 412694000528 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 412694000529 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 412694000530 elongation factor Tu; Reviewed; Region: PRK00049 412694000531 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 412694000532 G1 box; other site 412694000533 GEF interaction site [polypeptide binding]; other site 412694000534 GTP/Mg2+ binding site [chemical binding]; other site 412694000535 Switch I region; other site 412694000536 G2 box; other site 412694000537 G3 box; other site 412694000538 Switch II region; other site 412694000539 G4 box; other site 412694000540 G5 box; other site 412694000541 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 412694000542 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 412694000543 Antibiotic Binding Site [chemical binding]; other site 412694000544 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 412694000545 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 412694000546 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 412694000547 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 412694000548 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 412694000549 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 412694000550 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 412694000551 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 412694000552 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 412694000553 putative translocon binding site; other site 412694000554 protein-rRNA interface [nucleotide binding]; other site 412694000555 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 412694000556 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 412694000557 G-X-X-G motif; other site 412694000558 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 412694000559 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 412694000560 23S rRNA interface [nucleotide binding]; other site 412694000561 5S rRNA interface [nucleotide binding]; other site 412694000562 putative antibiotic binding site [chemical binding]; other site 412694000563 L25 interface [polypeptide binding]; other site 412694000564 L27 interface [polypeptide binding]; other site 412694000565 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 412694000566 23S rRNA interface [nucleotide binding]; other site 412694000567 putative translocon interaction site; other site 412694000568 signal recognition particle (SRP54) interaction site; other site 412694000569 L23 interface [polypeptide binding]; other site 412694000570 trigger factor interaction site; other site 412694000571 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 412694000572 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 412694000573 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 412694000574 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 412694000575 RNA binding site [nucleotide binding]; other site 412694000576 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 412694000577 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 412694000578 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 412694000579 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 412694000580 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 412694000581 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 412694000582 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 412694000583 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 412694000584 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 412694000585 5S rRNA interface [nucleotide binding]; other site 412694000586 L27 interface [polypeptide binding]; other site 412694000587 23S rRNA interface [nucleotide binding]; other site 412694000588 L5 interface [polypeptide binding]; other site 412694000589 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 412694000590 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 412694000591 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 412694000592 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 412694000593 23S rRNA binding site [nucleotide binding]; other site 412694000594 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 412694000595 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 412694000596 SecY translocase; Region: SecY; pfam00344 412694000597 adenylate kinase; Reviewed; Region: adk; PRK00279 412694000598 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 412694000599 AMP-binding site [chemical binding]; other site 412694000600 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 412694000601 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 412694000602 active site 412694000603 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 412694000604 rRNA binding site [nucleotide binding]; other site 412694000605 predicted 30S ribosome binding site; other site 412694000606 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 412694000607 30S ribosomal protein S13; Region: bact_S13; TIGR03631 412694000608 30S ribosomal protein S11; Validated; Region: PRK05309 412694000609 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 412694000610 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 412694000611 alphaNTD - beta interaction site [polypeptide binding]; other site 412694000612 alphaNTD homodimer interface [polypeptide binding]; other site 412694000613 alphaNTD - beta' interaction site [polypeptide binding]; other site 412694000614 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 412694000615 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 412694000616 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 412694000617 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 412694000618 Walker A/P-loop; other site 412694000619 ATP binding site [chemical binding]; other site 412694000620 Q-loop/lid; other site 412694000621 ABC transporter signature motif; other site 412694000622 Walker B; other site 412694000623 D-loop; other site 412694000624 H-loop/switch region; other site 412694000625 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 412694000626 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 412694000627 Walker A/P-loop; other site 412694000628 ATP binding site [chemical binding]; other site 412694000629 Q-loop/lid; other site 412694000630 ABC transporter signature motif; other site 412694000631 Walker B; other site 412694000632 D-loop; other site 412694000633 H-loop/switch region; other site 412694000634 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 412694000635 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 412694000636 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 412694000637 dimerization interface 3.5A [polypeptide binding]; other site 412694000638 active site 412694000639 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 412694000640 23S rRNA interface [nucleotide binding]; other site 412694000641 L3 interface [polypeptide binding]; other site 412694000642 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 412694000643 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 412694000644 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 412694000645 active site 412694000646 metal binding site [ion binding]; metal-binding site 412694000647 Domain of unknown function DUF59; Region: DUF59; pfam01883 412694000648 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 412694000649 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 412694000650 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 412694000651 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 412694000652 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 412694000653 NodB motif; other site 412694000654 putative active site [active] 412694000655 putative catalytic site [active] 412694000656 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 412694000657 Arginase family; Region: Arginase; cd09989 412694000658 agmatinase; Region: agmatinase; TIGR01230 412694000659 active site 412694000660 Mn binding site [ion binding]; other site 412694000661 oligomer interface [polypeptide binding]; other site 412694000662 Uncharacterized conserved protein [Function unknown]; Region: COG1624 412694000663 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 412694000664 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 412694000665 YbbR-like protein; Region: YbbR; pfam07949 412694000666 YbbR-like protein; Region: YbbR; pfam07949 412694000667 YbbR-like protein; Region: YbbR; pfam07949 412694000668 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 412694000669 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 412694000670 active site 412694000671 substrate binding site [chemical binding]; other site 412694000672 metal binding site [ion binding]; metal-binding site 412694000673 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 412694000674 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 412694000675 glutaminase active site [active] 412694000676 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 412694000677 dimer interface [polypeptide binding]; other site 412694000678 active site 412694000679 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 412694000680 dimer interface [polypeptide binding]; other site 412694000681 active site 412694000682 Transcriptional regulators [Transcription]; Region: GntR; COG1802 412694000683 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412694000684 DNA-binding site [nucleotide binding]; DNA binding site 412694000685 FCD domain; Region: FCD; pfam07729 412694000686 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 412694000687 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 412694000688 N- and C-terminal domain interface [polypeptide binding]; other site 412694000689 active site 412694000690 catalytic site [active] 412694000691 metal binding site [ion binding]; metal-binding site 412694000692 carbohydrate binding site [chemical binding]; other site 412694000693 ATP binding site [chemical binding]; other site 412694000694 fructuronate transporter; Provisional; Region: PRK10034; cl15264 412694000695 gluconate transporter; Region: gntP; TIGR00791 412694000696 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 412694000697 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 412694000698 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 412694000699 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 412694000700 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 412694000701 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 412694000702 HTH-like domain; Region: HTH_21; pfam13276 412694000703 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412694000704 Integrase core domain; Region: rve; pfam00665 412694000705 Integrase core domain; Region: rve_2; pfam13333 412694000706 Transposase; Region: HTH_Tnp_1; pfam01527 412694000707 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 412694000708 Predicted membrane protein [Function unknown]; Region: COG2259 412694000709 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 412694000710 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 412694000711 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 412694000712 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412694000713 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 412694000714 DNA binding residues [nucleotide binding] 412694000715 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 412694000716 classical (c) SDRs; Region: SDR_c; cd05233 412694000717 NAD(P) binding site [chemical binding]; other site 412694000718 active site 412694000719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694000720 ABC-ATPase subunit interface; other site 412694000721 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 412694000722 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 412694000723 Walker A/P-loop; other site 412694000724 ATP binding site [chemical binding]; other site 412694000725 Q-loop/lid; other site 412694000726 ABC transporter signature motif; other site 412694000727 Walker B; other site 412694000728 D-loop; other site 412694000729 H-loop/switch region; other site 412694000730 NIL domain; Region: NIL; pfam09383 412694000731 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 412694000732 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 412694000733 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 412694000734 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 412694000735 putative NAD(P) binding site [chemical binding]; other site 412694000736 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 412694000737 FAD binding domain; Region: FAD_binding_4; pfam01565 412694000738 Major Facilitator Superfamily; Region: MFS_1; pfam07690 412694000739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694000740 putative substrate translocation pore; other site 412694000741 Domain of unknown function (DUF3981); Region: DUF3981; pfam13139 412694000742 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 412694000743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694000744 putative substrate translocation pore; other site 412694000745 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 412694000746 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 412694000747 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694000748 dimer interface [polypeptide binding]; other site 412694000749 conserved gate region; other site 412694000750 putative PBP binding loops; other site 412694000751 ABC-ATPase subunit interface; other site 412694000752 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 412694000753 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 412694000754 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694000755 dimer interface [polypeptide binding]; other site 412694000756 conserved gate region; other site 412694000757 putative PBP binding loops; other site 412694000758 ABC-ATPase subunit interface; other site 412694000759 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 412694000760 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 412694000761 Walker A/P-loop; other site 412694000762 ATP binding site [chemical binding]; other site 412694000763 Q-loop/lid; other site 412694000764 ABC transporter signature motif; other site 412694000765 Walker B; other site 412694000766 D-loop; other site 412694000767 H-loop/switch region; other site 412694000768 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 412694000769 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 412694000770 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 412694000771 Walker A/P-loop; other site 412694000772 ATP binding site [chemical binding]; other site 412694000773 Q-loop/lid; other site 412694000774 ABC transporter signature motif; other site 412694000775 Walker B; other site 412694000776 D-loop; other site 412694000777 H-loop/switch region; other site 412694000778 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 412694000779 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 412694000780 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 412694000781 peptide binding site [polypeptide binding]; other site 412694000782 YusW-like protein; Region: YusW; pfam14039 412694000783 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412694000784 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 412694000785 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412694000786 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412694000787 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412694000788 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 412694000789 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 412694000790 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 412694000791 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 412694000792 peptide binding site [polypeptide binding]; other site 412694000793 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 412694000794 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 412694000795 peptide binding site [polypeptide binding]; other site 412694000796 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 412694000797 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 412694000798 active site 412694000799 catalytic tetrad [active] 412694000800 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07634 412694000801 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 412694000802 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 412694000803 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 412694000804 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 412694000805 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694000806 dimer interface [polypeptide binding]; other site 412694000807 conserved gate region; other site 412694000808 putative PBP binding loops; other site 412694000809 ABC-ATPase subunit interface; other site 412694000810 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 412694000811 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 412694000812 dimerization interface [polypeptide binding]; other site 412694000813 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 412694000814 membrane-bound complex binding site; other site 412694000815 hinge residues; other site 412694000816 DNA binding domain, excisionase family; Region: excise; TIGR01764 412694000817 PBP superfamily domain; Region: PBP_like; pfam12727 412694000818 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412694000819 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412694000820 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 412694000821 putative dimerization interface [polypeptide binding]; other site 412694000822 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 412694000823 EamA-like transporter family; Region: EamA; pfam00892 412694000824 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 412694000825 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 412694000826 putative acyl-acceptor binding pocket; other site 412694000827 Transcriptional regulators [Transcription]; Region: PurR; COG1609 412694000828 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 412694000829 DNA binding site [nucleotide binding] 412694000830 domain linker motif; other site 412694000831 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 412694000832 putative ligand binding site [chemical binding]; other site 412694000833 putative dimerization interface [polypeptide binding]; other site 412694000834 Uncharacterized conserved protein [Function unknown]; Region: COG1284 412694000835 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 412694000836 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 412694000837 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 412694000838 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 412694000839 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 412694000840 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 412694000841 active site 412694000842 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 412694000843 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 412694000844 C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have...; Region: LYZ1; cl17441 412694000845 lysozyme catalytic site [active] 412694000846 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 412694000847 nucleotide binding site/active site [active] 412694000848 HIT family signature motif; other site 412694000849 catalytic residue [active] 412694000850 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 412694000851 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 412694000852 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 412694000853 ABC transporter; Region: ABC_tran_2; pfam12848 412694000854 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 412694000855 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 412694000856 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 412694000857 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 412694000858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694000859 dimer interface [polypeptide binding]; other site 412694000860 conserved gate region; other site 412694000861 putative PBP binding loops; other site 412694000862 ABC-ATPase subunit interface; other site 412694000863 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 412694000864 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 412694000865 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694000866 dimer interface [polypeptide binding]; other site 412694000867 conserved gate region; other site 412694000868 putative PBP binding loops; other site 412694000869 ABC-ATPase subunit interface; other site 412694000870 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 412694000871 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 412694000872 Walker A/P-loop; other site 412694000873 ATP binding site [chemical binding]; other site 412694000874 Q-loop/lid; other site 412694000875 ABC transporter signature motif; other site 412694000876 Walker B; other site 412694000877 D-loop; other site 412694000878 H-loop/switch region; other site 412694000879 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 412694000880 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 412694000881 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 412694000882 Walker A/P-loop; other site 412694000883 ATP binding site [chemical binding]; other site 412694000884 Q-loop/lid; other site 412694000885 ABC transporter signature motif; other site 412694000886 Walker B; other site 412694000887 D-loop; other site 412694000888 H-loop/switch region; other site 412694000889 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 412694000890 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412694000891 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 412694000892 active site 412694000893 motif I; other site 412694000894 motif II; other site 412694000895 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412694000896 motif II; other site 412694000897 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 412694000898 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 412694000899 dimer interface [polypeptide binding]; other site 412694000900 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 412694000901 active site 412694000902 Fe binding site [ion binding]; other site 412694000903 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 412694000904 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 412694000905 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 412694000906 amino acid transporter; Region: 2A0306; TIGR00909 412694000907 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 412694000908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694000909 Major Facilitator Superfamily; Region: MFS_1; pfam07690 412694000910 putative substrate translocation pore; other site 412694000911 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 412694000912 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 412694000913 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 412694000914 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 412694000915 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 412694000916 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 412694000917 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 412694000918 helicase 45; Provisional; Region: PTZ00424 412694000919 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 412694000920 ATP binding site [chemical binding]; other site 412694000921 Mg++ binding site [ion binding]; other site 412694000922 motif III; other site 412694000923 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412694000924 nucleotide binding region [chemical binding]; other site 412694000925 ATP-binding site [chemical binding]; other site 412694000926 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 412694000927 Rhomboid family; Region: Rhomboid; pfam01694 412694000928 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 412694000929 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 412694000930 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 412694000931 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 412694000932 alanine racemase; Reviewed; Region: alr; PRK00053 412694000933 active site 412694000934 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 412694000935 dimer interface [polypeptide binding]; other site 412694000936 substrate binding site [chemical binding]; other site 412694000937 catalytic residues [active] 412694000938 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 412694000939 PemK-like protein; Region: PemK; pfam02452 412694000940 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 412694000941 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 412694000942 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 412694000943 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 412694000944 RNA binding site [nucleotide binding]; other site 412694000945 hypothetical protein; Provisional; Region: PRK04351 412694000946 SprT homologues; Region: SprT; cl01182 412694000947 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 412694000948 Glycoprotease family; Region: Peptidase_M22; pfam00814 412694000949 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 412694000950 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 412694000951 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694000952 Coenzyme A binding pocket [chemical binding]; other site 412694000953 UGMP family protein; Validated; Region: PRK09604 412694000954 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 412694000955 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 412694000956 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 412694000957 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 412694000958 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 412694000959 ABC transporter; Region: ABC_tran_2; pfam12848 412694000960 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 412694000961 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 412694000962 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 412694000963 CoA binding domain; Region: CoA_binding; pfam02629 412694000964 CAAX protease self-immunity; Region: Abi; pfam02517 412694000965 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 412694000966 oligomerisation interface [polypeptide binding]; other site 412694000967 mobile loop; other site 412694000968 roof hairpin; other site 412694000969 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 412694000970 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 412694000971 ring oligomerisation interface [polypeptide binding]; other site 412694000972 ATP/Mg binding site [chemical binding]; other site 412694000973 stacking interactions; other site 412694000974 hinge regions; other site 412694000975 Uncharacterized conserved protein [Function unknown]; Region: COG5444 412694000976 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 412694000977 GMP synthase; Reviewed; Region: guaA; PRK00074 412694000978 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 412694000979 AMP/PPi binding site [chemical binding]; other site 412694000980 candidate oxyanion hole; other site 412694000981 catalytic triad [active] 412694000982 potential glutamine specificity residues [chemical binding]; other site 412694000983 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 412694000984 ATP Binding subdomain [chemical binding]; other site 412694000985 Ligand Binding sites [chemical binding]; other site 412694000986 Dimerization subdomain; other site 412694000987 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 412694000988 AP2 domain; Region: AP2; pfam00847 412694000989 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 412694000990 Int/Topo IB signature motif; other site 412694000991 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 412694000992 putative replication initiation protein; Region: PHA00330 412694000993 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412694000994 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 412694000995 Walker A motif; other site 412694000996 ATP binding site [chemical binding]; other site 412694000997 Walker B motif; other site 412694000998 arginine finger; other site 412694000999 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 412694001000 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412694001001 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694001002 active site 412694001003 phosphorylation site [posttranslational modification] 412694001004 intermolecular recognition site; other site 412694001005 dimerization interface [polypeptide binding]; other site 412694001006 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412694001007 DNA binding site [nucleotide binding] 412694001008 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412694001009 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412694001010 dimerization interface [polypeptide binding]; other site 412694001011 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694001012 dimer interface [polypeptide binding]; other site 412694001013 phosphorylation site [posttranslational modification] 412694001014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694001015 ATP binding site [chemical binding]; other site 412694001016 Mg2+ binding site [ion binding]; other site 412694001017 G-X-G motif; other site 412694001018 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 412694001019 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 412694001020 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 412694001021 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 412694001022 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 412694001023 catalytic residues [active] 412694001024 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412694001025 NAD(P) binding site [chemical binding]; other site 412694001026 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 412694001027 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 412694001028 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 412694001029 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 412694001030 Walker A/P-loop; other site 412694001031 ATP binding site [chemical binding]; other site 412694001032 Q-loop/lid; other site 412694001033 ABC transporter signature motif; other site 412694001034 Walker B; other site 412694001035 D-loop; other site 412694001036 H-loop/switch region; other site 412694001037 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412694001038 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694001039 dimer interface [polypeptide binding]; other site 412694001040 phosphorylation site [posttranslational modification] 412694001041 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694001042 ATP binding site [chemical binding]; other site 412694001043 Mg2+ binding site [ion binding]; other site 412694001044 G-X-G motif; other site 412694001045 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412694001046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694001047 active site 412694001048 phosphorylation site [posttranslational modification] 412694001049 intermolecular recognition site; other site 412694001050 dimerization interface [polypeptide binding]; other site 412694001051 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412694001052 DNA binding site [nucleotide binding] 412694001053 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 412694001054 EamA-like transporter family; Region: EamA; pfam00892 412694001055 EamA-like transporter family; Region: EamA; pfam00892 412694001056 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 412694001057 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 412694001058 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 412694001059 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 412694001060 NAD binding site [chemical binding]; other site 412694001061 ATP-grasp domain; Region: ATP-grasp; pfam02222 412694001062 adenylosuccinate lyase; Provisional; Region: PRK07492 412694001063 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 412694001064 tetramer interface [polypeptide binding]; other site 412694001065 active site 412694001066 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 412694001067 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 412694001068 ATP binding site [chemical binding]; other site 412694001069 active site 412694001070 substrate binding site [chemical binding]; other site 412694001071 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 412694001072 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 412694001073 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 412694001074 putative active site [active] 412694001075 catalytic triad [active] 412694001076 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 412694001077 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 412694001078 dimerization interface [polypeptide binding]; other site 412694001079 ATP binding site [chemical binding]; other site 412694001080 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 412694001081 dimerization interface [polypeptide binding]; other site 412694001082 ATP binding site [chemical binding]; other site 412694001083 amidophosphoribosyltransferase; Provisional; Region: PRK06781 412694001084 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 412694001085 active site 412694001086 tetramer interface [polypeptide binding]; other site 412694001087 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 412694001088 active site 412694001089 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 412694001090 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 412694001091 dimerization interface [polypeptide binding]; other site 412694001092 putative ATP binding site [chemical binding]; other site 412694001093 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 412694001094 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 412694001095 active site 412694001096 substrate binding site [chemical binding]; other site 412694001097 cosubstrate binding site; other site 412694001098 catalytic site [active] 412694001099 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 412694001100 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 412694001101 purine monophosphate binding site [chemical binding]; other site 412694001102 dimer interface [polypeptide binding]; other site 412694001103 putative catalytic residues [active] 412694001104 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 412694001105 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 412694001106 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 412694001107 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 412694001108 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 412694001109 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 412694001110 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 412694001111 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 412694001112 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 412694001113 PcrB family; Region: PcrB; pfam01884 412694001114 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 412694001115 substrate binding site [chemical binding]; other site 412694001116 putative active site [active] 412694001117 dimer interface [polypeptide binding]; other site 412694001118 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 412694001119 Part of AAA domain; Region: AAA_19; pfam13245 412694001120 Family description; Region: UvrD_C_2; pfam13538 412694001121 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 412694001122 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 412694001123 nucleotide binding pocket [chemical binding]; other site 412694001124 K-X-D-G motif; other site 412694001125 catalytic site [active] 412694001126 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 412694001127 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 412694001128 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 412694001129 Dimer interface [polypeptide binding]; other site 412694001130 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 412694001131 putative dimer interface [polypeptide binding]; other site 412694001132 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 412694001133 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 412694001134 putative dimer interface [polypeptide binding]; other site 412694001135 hypothetical protein; Provisional; Region: PRK10621 412694001136 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 412694001137 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 412694001138 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 412694001139 Glutamate binding site [chemical binding]; other site 412694001140 homodimer interface [polypeptide binding]; other site 412694001141 NAD binding site [chemical binding]; other site 412694001142 catalytic residues [active] 412694001143 Isochorismatase family; Region: Isochorismatase; pfam00857 412694001144 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 412694001145 catalytic triad [active] 412694001146 conserved cis-peptide bond; other site 412694001147 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 412694001148 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 412694001149 Walker A/P-loop; other site 412694001150 ATP binding site [chemical binding]; other site 412694001151 Q-loop/lid; other site 412694001152 ABC transporter signature motif; other site 412694001153 Walker B; other site 412694001154 D-loop; other site 412694001155 H-loop/switch region; other site 412694001156 NIL domain; Region: NIL; pfam09383 412694001157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694001158 dimer interface [polypeptide binding]; other site 412694001159 conserved gate region; other site 412694001160 ABC-ATPase subunit interface; other site 412694001161 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 412694001162 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 412694001163 Transposase; Region: HTH_Tnp_1; pfam01527 412694001164 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 412694001165 HTH-like domain; Region: HTH_21; pfam13276 412694001166 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412694001167 Integrase core domain; Region: rve; pfam00665 412694001168 Integrase core domain; Region: rve_2; pfam13333 412694001169 Protein of unknown function (DUF3926); Region: DUF3926; pfam13080 412694001170 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 412694001171 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 412694001172 P loop; other site 412694001173 Nucleotide binding site [chemical binding]; other site 412694001174 DTAP/Switch II; other site 412694001175 Switch I; other site 412694001176 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 412694001177 putative dimer interface [polypeptide binding]; other site 412694001178 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 412694001179 MarR family; Region: MarR; pfam01047 412694001180 MarR family; Region: MarR_2; cl17246 412694001181 yiaA/B two helix domain; Region: YiaAB; pfam05360 412694001182 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 412694001183 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 412694001184 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 412694001185 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 412694001186 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 412694001187 GatB domain; Region: GatB_Yqey; pfam02637 412694001188 putative lipid kinase; Reviewed; Region: PRK13337 412694001189 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 412694001190 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 412694001191 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412694001192 motif II; other site 412694001193 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 412694001194 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 412694001195 inhibitor-cofactor binding pocket; inhibition site 412694001196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694001197 catalytic residue [active] 412694001198 PAS domain; Region: PAS_9; pfam13426 412694001199 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 412694001200 putative active site [active] 412694001201 heme pocket [chemical binding]; other site 412694001202 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 412694001203 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412694001204 Walker A motif; other site 412694001205 ATP binding site [chemical binding]; other site 412694001206 Walker B motif; other site 412694001207 arginine finger; other site 412694001208 succinic semialdehyde dehydrogenase; Region: PLN02278 412694001209 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 412694001210 tetramerization interface [polypeptide binding]; other site 412694001211 NAD(P) binding site [chemical binding]; other site 412694001212 catalytic residues [active] 412694001213 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 412694001214 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 412694001215 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 412694001216 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 412694001217 putative active site [active] 412694001218 putative metal binding site [ion binding]; other site 412694001219 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 412694001220 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 412694001221 putative active site [active] 412694001222 putative metal binding site [ion binding]; other site 412694001223 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 412694001224 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 412694001225 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 412694001226 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 412694001227 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 412694001228 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694001229 S-adenosylmethionine binding site [chemical binding]; other site 412694001230 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 412694001231 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 412694001232 FMN binding site [chemical binding]; other site 412694001233 active site 412694001234 catalytic residues [active] 412694001235 substrate binding site [chemical binding]; other site 412694001236 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 412694001237 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 412694001238 GAF domain; Region: GAF_2; pfam13185 412694001239 GAF domain; Region: GAF_3; pfam13492 412694001240 PAS fold; Region: PAS_4; pfam08448 412694001241 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694001242 dimer interface [polypeptide binding]; other site 412694001243 phosphorylation site [posttranslational modification] 412694001244 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694001245 ATP binding site [chemical binding]; other site 412694001246 Mg2+ binding site [ion binding]; other site 412694001247 G-X-G motif; other site 412694001248 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 412694001249 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 412694001250 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 412694001251 Protein of unknown function DUF45; Region: DUF45; pfam01863 412694001252 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 412694001253 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 412694001254 active site 412694001255 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 412694001256 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 412694001257 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 412694001258 metal binding site [ion binding]; metal-binding site 412694001259 putative dimer interface [polypeptide binding]; other site 412694001260 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694001261 S-adenosylmethionine binding site [chemical binding]; other site 412694001262 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 412694001263 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 412694001264 catalytic residue [active] 412694001265 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 412694001266 catalytic residues [active] 412694001267 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 412694001268 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 412694001269 peroxiredoxin; Region: AhpC; TIGR03137 412694001270 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 412694001271 dimer interface [polypeptide binding]; other site 412694001272 decamer (pentamer of dimers) interface [polypeptide binding]; other site 412694001273 catalytic triad [active] 412694001274 peroxidatic and resolving cysteines [active] 412694001275 5-methylribose kinase; Reviewed; Region: PRK12396 412694001276 Phosphotransferase enzyme family; Region: APH; pfam01636 412694001277 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 412694001278 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 412694001279 L-fuculose phosphate aldolase; Provisional; Region: PRK06833 412694001280 intersubunit interface [polypeptide binding]; other site 412694001281 active site 412694001282 Zn2+ binding site [ion binding]; other site 412694001283 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 412694001284 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 412694001285 ABC-ATPase subunit interface; other site 412694001286 dimer interface [polypeptide binding]; other site 412694001287 putative PBP binding regions; other site 412694001288 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 412694001289 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 412694001290 ABC-ATPase subunit interface; other site 412694001291 dimer interface [polypeptide binding]; other site 412694001292 putative PBP binding regions; other site 412694001293 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 412694001294 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 412694001295 putative ligand binding residues [chemical binding]; other site 412694001296 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 412694001297 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 412694001298 DNA binding domain, excisionase family; Region: excise; TIGR01764 412694001299 Sm and related proteins; Region: Sm_like; cl00259 412694001300 Sm1 motif; other site 412694001301 RNA binding site [nucleotide binding]; other site 412694001302 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 412694001303 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 412694001304 hypothetical protein; Provisional; Region: PRK06851 412694001305 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 412694001306 Walker A motif; other site 412694001307 ATP binding site [chemical binding]; other site 412694001308 NTPase; Region: NTPase_1; cl17478 412694001309 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 412694001310 benzoate transport; Region: 2A0115; TIGR00895 412694001311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694001312 putative substrate translocation pore; other site 412694001313 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 412694001314 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 412694001315 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 412694001316 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 412694001317 [2Fe-2S] cluster binding site [ion binding]; other site 412694001318 Fatty acid desaturase; Region: FA_desaturase; pfam00487 412694001319 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 412694001320 putative di-iron ligands [ion binding]; other site 412694001321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694001322 dimer interface [polypeptide binding]; other site 412694001323 conserved gate region; other site 412694001324 putative PBP binding loops; other site 412694001325 ABC-ATPase subunit interface; other site 412694001326 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 412694001327 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 412694001328 substrate binding pocket [chemical binding]; other site 412694001329 membrane-bound complex binding site; other site 412694001330 hinge residues; other site 412694001331 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 412694001332 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 412694001333 Walker A/P-loop; other site 412694001334 ATP binding site [chemical binding]; other site 412694001335 Q-loop/lid; other site 412694001336 ABC transporter signature motif; other site 412694001337 Walker B; other site 412694001338 D-loop; other site 412694001339 H-loop/switch region; other site 412694001340 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 412694001341 HAMP domain; Region: HAMP; pfam00672 412694001342 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 412694001343 dimer interface [polypeptide binding]; other site 412694001344 putative CheW interface [polypeptide binding]; other site 412694001345 Arginine repressor [Transcription]; Region: ArgR; COG1438 412694001346 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 412694001347 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 412694001348 arginine deiminase; Provisional; Region: PRK01388 412694001349 ornithine carbamoyltransferase; Validated; Region: PRK02102 412694001350 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 412694001351 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 412694001352 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 412694001353 carbamate kinase; Reviewed; Region: PRK12686 412694001354 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 412694001355 putative substrate binding site [chemical binding]; other site 412694001356 nucleotide binding site [chemical binding]; other site 412694001357 nucleotide binding site [chemical binding]; other site 412694001358 homodimer interface [polypeptide binding]; other site 412694001359 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 412694001360 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 412694001361 ligand binding site [chemical binding]; other site 412694001362 flexible hinge region; other site 412694001363 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 412694001364 putative switch regulator; other site 412694001365 non-specific DNA interactions [nucleotide binding]; other site 412694001366 DNA binding site [nucleotide binding] 412694001367 sequence specific DNA binding site [nucleotide binding]; other site 412694001368 putative cAMP binding site [chemical binding]; other site 412694001369 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 412694001370 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 412694001371 Ca binding site [ion binding]; other site 412694001372 active site 412694001373 catalytic site [active] 412694001374 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 412694001375 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 412694001376 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 412694001377 active site turn [active] 412694001378 phosphorylation site [posttranslational modification] 412694001379 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 412694001380 putative catalytic site [active] 412694001381 putative metal binding site [ion binding]; other site 412694001382 putative phosphate binding site [ion binding]; other site 412694001383 Predicted membrane protein [Function unknown]; Region: COG1511 412694001384 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 412694001385 Predicted membrane protein [Function unknown]; Region: COG1511 412694001386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694001387 DNA topoisomerase III; Provisional; Region: PRK07726 412694001388 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 412694001389 active site 412694001390 putative interdomain interaction site [polypeptide binding]; other site 412694001391 putative metal-binding site [ion binding]; other site 412694001392 putative nucleotide binding site [chemical binding]; other site 412694001393 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 412694001394 domain I; other site 412694001395 DNA binding groove [nucleotide binding] 412694001396 phosphate binding site [ion binding]; other site 412694001397 domain II; other site 412694001398 domain III; other site 412694001399 nucleotide binding site [chemical binding]; other site 412694001400 catalytic site [active] 412694001401 domain IV; other site 412694001402 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 412694001403 substrate binding site [chemical binding]; other site 412694001404 multimerization interface [polypeptide binding]; other site 412694001405 ATP binding site [chemical binding]; other site 412694001406 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 412694001407 thiamine phosphate binding site [chemical binding]; other site 412694001408 active site 412694001409 pyrophosphate binding site [ion binding]; other site 412694001410 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 412694001411 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 412694001412 HAMP domain; Region: HAMP; pfam00672 412694001413 dimerization interface [polypeptide binding]; other site 412694001414 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 412694001415 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 412694001416 dimer interface [polypeptide binding]; other site 412694001417 putative CheW interface [polypeptide binding]; other site 412694001418 Domain of unknown function DUF77; Region: DUF77; pfam01910 412694001419 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 412694001420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694001421 dimer interface [polypeptide binding]; other site 412694001422 conserved gate region; other site 412694001423 putative PBP binding loops; other site 412694001424 ABC-ATPase subunit interface; other site 412694001425 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 412694001426 NMT1/THI5 like; Region: NMT1; pfam09084 412694001427 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 412694001428 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 412694001429 Walker A/P-loop; other site 412694001430 ATP binding site [chemical binding]; other site 412694001431 Q-loop/lid; other site 412694001432 ABC transporter signature motif; other site 412694001433 Walker B; other site 412694001434 D-loop; other site 412694001435 H-loop/switch region; other site 412694001436 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 412694001437 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 412694001438 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412694001439 H-loop/switch region; other site 412694001440 ABC transporter; Region: ABC_tran_2; pfam12848 412694001441 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 412694001442 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 412694001443 Glyco_18 domain; Region: Glyco_18; smart00636 412694001444 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 412694001445 active site 412694001446 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 412694001447 Interdomain contacts; other site 412694001448 Cytokine receptor motif; other site 412694001449 CBD_II domain; Region: CBD_II; smart00637 412694001450 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 412694001451 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 412694001452 catalytic residues [active] 412694001453 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412694001454 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412694001455 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 412694001456 H+ Antiporter protein; Region: 2A0121; TIGR00900 412694001457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694001458 putative substrate translocation pore; other site 412694001459 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 412694001460 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412694001461 non-specific DNA binding site [nucleotide binding]; other site 412694001462 salt bridge; other site 412694001463 sequence-specific DNA binding site [nucleotide binding]; other site 412694001464 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 412694001465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694001466 putative substrate translocation pore; other site 412694001467 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 412694001468 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 412694001469 prolyl-tRNA synthetase; Provisional; Region: PRK08661 412694001470 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 412694001471 dimer interface [polypeptide binding]; other site 412694001472 motif 1; other site 412694001473 active site 412694001474 motif 2; other site 412694001475 motif 3; other site 412694001476 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 412694001477 anticodon binding site; other site 412694001478 zinc-binding site [ion binding]; other site 412694001479 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 412694001480 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 412694001481 nucleotide binding site [chemical binding]; other site 412694001482 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 412694001483 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 412694001484 putative metal binding site [ion binding]; other site 412694001485 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 412694001486 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 412694001487 putative metal binding site [ion binding]; other site 412694001488 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 412694001489 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 412694001490 putative metal binding site [ion binding]; other site 412694001491 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 412694001492 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 412694001493 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 412694001494 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 412694001495 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 412694001496 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 412694001497 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 412694001498 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 412694001499 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 412694001500 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 412694001501 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 412694001502 Low molecular weight phosphatase family; Region: LMWPc; cd00115 412694001503 active site 412694001504 Domain of unknown function (DUF4075); Region: DUF4075; pfam13294 412694001505 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 412694001506 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 412694001507 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 412694001508 Soluble P-type ATPase [General function prediction only]; Region: COG4087 412694001509 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 412694001510 EamA-like transporter family; Region: EamA; pfam00892 412694001511 EamA-like transporter family; Region: EamA; pfam00892 412694001512 YhhN-like protein; Region: YhhN; pfam07947 412694001513 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 412694001514 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 412694001515 Catalytic site [active] 412694001516 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412694001517 binding surface 412694001518 Tetratricopeptide repeat; Region: TPR_16; pfam13432 412694001519 TPR motif; other site 412694001520 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 412694001521 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 412694001522 Predicted membrane protein [Function unknown]; Region: COG2510 412694001523 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 412694001524 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 412694001525 calcium/proton exchanger (cax); Region: cax; TIGR00378 412694001526 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 412694001527 YfkD-like protein; Region: YfkD; pfam14167 412694001528 Radical SAM superfamily; Region: Radical_SAM; pfam04055 412694001529 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412694001530 FeS/SAM binding site; other site 412694001531 YfkB-like domain; Region: YfkB; pfam08756 412694001532 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 412694001533 Fumarase C-terminus; Region: Fumerase_C; pfam05683 412694001534 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 412694001535 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 412694001536 NodB motif; other site 412694001537 active site 412694001538 catalytic site [active] 412694001539 Cd binding site [ion binding]; other site 412694001540 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 412694001541 endonuclease III; Region: ENDO3c; smart00478 412694001542 minor groove reading motif; other site 412694001543 helix-hairpin-helix signature motif; other site 412694001544 substrate binding pocket [chemical binding]; other site 412694001545 active site 412694001546 TRAM domain; Region: TRAM; pfam01938 412694001547 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 412694001548 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694001549 S-adenosylmethionine binding site [chemical binding]; other site 412694001550 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 412694001551 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 412694001552 dimerization interface 3.5A [polypeptide binding]; other site 412694001553 active site 412694001554 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 412694001555 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412694001556 Walker A motif; other site 412694001557 ATP binding site [chemical binding]; other site 412694001558 Walker B motif; other site 412694001559 arginine finger; other site 412694001560 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 412694001561 hypothetical protein; Validated; Region: PRK06748 412694001562 S-methylmethionine transporter; Provisional; Region: PRK11387 412694001563 acetylornithine deacetylase; Validated; Region: PRK08596 412694001564 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 412694001565 metal binding site [ion binding]; metal-binding site 412694001566 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 412694001567 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412694001568 non-specific DNA binding site [nucleotide binding]; other site 412694001569 salt bridge; other site 412694001570 sequence-specific DNA binding site [nucleotide binding]; other site 412694001571 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 412694001572 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 412694001573 Domain of unknown function DUF; Region: DUF204; pfam02659 412694001574 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 412694001575 glutaminase A; Region: Gln_ase; TIGR03814 412694001576 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 412694001577 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 412694001578 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 412694001579 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 412694001580 active site turn [active] 412694001581 phosphorylation site [posttranslational modification] 412694001582 Beta-lactamase; Region: Beta-lactamase; pfam00144 412694001583 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 412694001584 Sm and related proteins; Region: Sm_like; cl00259 412694001585 heptamer interface [polypeptide binding]; other site 412694001586 Sm1 motif; other site 412694001587 hexamer interface [polypeptide binding]; other site 412694001588 RNA binding site [nucleotide binding]; other site 412694001589 Sm2 motif; other site 412694001590 Sm and related proteins; Region: Sm_like; cl00259 412694001591 heptamer interface [polypeptide binding]; other site 412694001592 Sm1 motif; other site 412694001593 hexamer interface [polypeptide binding]; other site 412694001594 RNA binding site [nucleotide binding]; other site 412694001595 Sm2 motif; other site 412694001596 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 412694001597 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 412694001598 Ligand binding site; other site 412694001599 Putative Catalytic site; other site 412694001600 DXD motif; other site 412694001601 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 412694001602 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 412694001603 active site 412694001604 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 412694001605 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412694001606 NAD(P) binding site [chemical binding]; other site 412694001607 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 412694001608 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 412694001609 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 412694001610 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412694001611 NAD(P) binding site [chemical binding]; other site 412694001612 active site 412694001613 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 412694001614 active site 412694001615 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 412694001616 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 412694001617 active site 412694001618 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 412694001619 Pyruvate formate lyase 1; Region: PFL1; cd01678 412694001620 coenzyme A binding site [chemical binding]; other site 412694001621 active site 412694001622 catalytic residues [active] 412694001623 glycine loop; other site 412694001624 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 412694001625 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412694001626 FeS/SAM binding site; other site 412694001627 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 412694001628 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 412694001629 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 412694001630 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 412694001631 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 412694001632 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 412694001633 active site 412694001634 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 412694001635 TIGR01777 family protein; Region: yfcH 412694001636 putative NAD(P) binding site [chemical binding]; other site 412694001637 putative active site [active] 412694001638 recombination regulator RecX; Provisional; Region: recX; PRK14135 412694001639 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 412694001640 WVELL protein; Region: WVELL; pfam14043 412694001641 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 412694001642 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 412694001643 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 412694001644 minor groove reading motif; other site 412694001645 helix-hairpin-helix signature motif; other site 412694001646 substrate binding pocket [chemical binding]; other site 412694001647 active site 412694001648 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 412694001649 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 412694001650 DNA binding and oxoG recognition site [nucleotide binding] 412694001651 YgaB-like protein; Region: YgaB; pfam14182 412694001652 hypothetical protein; Provisional; Region: PRK13662 412694001653 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 412694001654 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 412694001655 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 412694001656 Walker A/P-loop; other site 412694001657 ATP binding site [chemical binding]; other site 412694001658 Q-loop/lid; other site 412694001659 ABC transporter signature motif; other site 412694001660 Walker B; other site 412694001661 D-loop; other site 412694001662 H-loop/switch region; other site 412694001663 Predicted membrane protein [Function unknown]; Region: COG4129 412694001664 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 412694001665 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 412694001666 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 412694001667 active site 412694001668 dimer interface [polypeptide binding]; other site 412694001669 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 412694001670 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 412694001671 active site 412694001672 FMN binding site [chemical binding]; other site 412694001673 substrate binding site [chemical binding]; other site 412694001674 3Fe-4S cluster binding site [ion binding]; other site 412694001675 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 412694001676 domain_subunit interface; other site 412694001677 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 412694001678 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 412694001679 inhibitor-cofactor binding pocket; inhibition site 412694001680 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694001681 catalytic residue [active] 412694001682 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 412694001683 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412694001684 Walker A/P-loop; other site 412694001685 ATP binding site [chemical binding]; other site 412694001686 Q-loop/lid; other site 412694001687 ABC transporter signature motif; other site 412694001688 Walker B; other site 412694001689 D-loop; other site 412694001690 H-loop/switch region; other site 412694001691 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 412694001692 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 412694001693 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 412694001694 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 412694001695 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 412694001696 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 412694001697 catalytic triad [active] 412694001698 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 412694001699 metal binding site 2 [ion binding]; metal-binding site 412694001700 putative DNA binding helix; other site 412694001701 metal binding site 1 [ion binding]; metal-binding site 412694001702 dimer interface [polypeptide binding]; other site 412694001703 structural Zn2+ binding site [ion binding]; other site 412694001704 hypothetical protein; Provisional; Region: PRK12378 412694001705 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 412694001706 nudix motif; other site 412694001707 thiazole/oxazole-forming peptide maturase, SagC family component; Region: cyclo_dehy_ocin; TIGR03603 412694001708 YcaO-like family; Region: YcaO; pfam02624 412694001709 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 412694001710 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 412694001711 NADPH bind site [chemical binding]; other site 412694001712 putative FMN binding site [chemical binding]; other site 412694001713 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 412694001714 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 412694001715 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412694001716 Walker A/P-loop; other site 412694001717 ATP binding site [chemical binding]; other site 412694001718 Q-loop/lid; other site 412694001719 ABC transporter signature motif; other site 412694001720 Walker B; other site 412694001721 D-loop; other site 412694001722 H-loop/switch region; other site 412694001723 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 412694001724 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 412694001725 Transglycosylase; Region: Transgly; pfam00912 412694001726 Thioredoxin; Region: Thioredoxin_4; pfam13462 412694001727 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 412694001728 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 412694001729 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 412694001730 epoxyqueuosine reductase; Region: TIGR00276 412694001731 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 412694001732 Putative amidase domain; Region: Amidase_6; pfam12671 412694001733 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 412694001734 PAS fold; Region: PAS_4; pfam08448 412694001735 PAS domain S-box; Region: sensory_box; TIGR00229 412694001736 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 412694001737 putative active site [active] 412694001738 heme pocket [chemical binding]; other site 412694001739 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 412694001740 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 412694001741 metal binding site [ion binding]; metal-binding site 412694001742 active site 412694001743 I-site; other site 412694001744 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 412694001745 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 412694001746 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 412694001747 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 412694001748 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 412694001749 heme-binding site [chemical binding]; other site 412694001750 Leucine rich repeat; Region: LRR_8; pfam13855 412694001751 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 412694001752 Substrate binding site [chemical binding]; other site 412694001753 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 412694001754 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 412694001755 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 412694001756 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 412694001757 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 412694001758 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 412694001759 Leucine-rich repeats; other site 412694001760 Substrate binding site [chemical binding]; other site 412694001761 Leucine rich repeat; Region: LRR_8; pfam13855 412694001762 Leucine rich repeat; Region: LRR_8; pfam13855 412694001763 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694001764 Coenzyme A binding pocket [chemical binding]; other site 412694001765 BCCT family transporter; Region: BCCT; pfam02028 412694001766 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 412694001767 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 412694001768 FOG: PKD repeat [General function prediction only]; Region: COG3291 412694001769 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 412694001770 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 412694001771 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 412694001772 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 412694001773 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 412694001774 Cache domain; Region: Cache_1; pfam02743 412694001775 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412694001776 dimerization interface [polypeptide binding]; other site 412694001777 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 412694001778 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 412694001779 dimer interface [polypeptide binding]; other site 412694001780 putative CheW interface [polypeptide binding]; other site 412694001781 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 412694001782 PAS domain; Region: PAS; smart00091 412694001783 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694001784 ATP binding site [chemical binding]; other site 412694001785 Mg2+ binding site [ion binding]; other site 412694001786 G-X-G motif; other site 412694001787 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 412694001788 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694001789 active site 412694001790 phosphorylation site [posttranslational modification] 412694001791 intermolecular recognition site; other site 412694001792 dimerization interface [polypeptide binding]; other site 412694001793 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 412694001794 Citrate transporter; Region: CitMHS; pfam03600 412694001795 hypothetical protein; Provisional; Region: PRK12784 412694001796 NosL; Region: NosL; cl01769 412694001797 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 412694001798 Ankyrin repeat; Region: Ank; pfam00023 412694001799 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 412694001800 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 412694001801 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 412694001802 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 412694001803 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412694001804 Walker A/P-loop; other site 412694001805 ATP binding site [chemical binding]; other site 412694001806 Q-loop/lid; other site 412694001807 ABC transporter signature motif; other site 412694001808 Walker B; other site 412694001809 D-loop; other site 412694001810 H-loop/switch region; other site 412694001811 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 412694001812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694001813 dimer interface [polypeptide binding]; other site 412694001814 conserved gate region; other site 412694001815 putative PBP binding loops; other site 412694001816 ABC-ATPase subunit interface; other site 412694001817 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 412694001818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 412694001819 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694001820 dimer interface [polypeptide binding]; other site 412694001821 conserved gate region; other site 412694001822 putative PBP binding loops; other site 412694001823 ABC-ATPase subunit interface; other site 412694001824 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 412694001825 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 412694001826 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 412694001827 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 412694001828 active site 412694001829 metal binding site [ion binding]; metal-binding site 412694001830 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412694001831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694001832 active site 412694001833 phosphorylation site [posttranslational modification] 412694001834 intermolecular recognition site; other site 412694001835 dimerization interface [polypeptide binding]; other site 412694001836 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412694001837 DNA binding site [nucleotide binding] 412694001838 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412694001839 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694001840 dimer interface [polypeptide binding]; other site 412694001841 phosphorylation site [posttranslational modification] 412694001842 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694001843 ATP binding site [chemical binding]; other site 412694001844 Mg2+ binding site [ion binding]; other site 412694001845 G-X-G motif; other site 412694001846 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 412694001847 putative active site [active] 412694001848 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 412694001849 Cache domain; Region: Cache_1; pfam02743 412694001850 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412694001851 dimerization interface [polypeptide binding]; other site 412694001852 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 412694001853 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 412694001854 dimer interface [polypeptide binding]; other site 412694001855 putative CheW interface [polypeptide binding]; other site 412694001856 sensory histidine kinase DcuS; Provisional; Region: PRK11086 412694001857 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694001858 ATP binding site [chemical binding]; other site 412694001859 Mg2+ binding site [ion binding]; other site 412694001860 G-X-G motif; other site 412694001861 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 412694001862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694001863 active site 412694001864 phosphorylation site [posttranslational modification] 412694001865 intermolecular recognition site; other site 412694001866 dimerization interface [polypeptide binding]; other site 412694001867 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 412694001868 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 412694001869 Malic enzyme, N-terminal domain; Region: malic; pfam00390 412694001870 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 412694001871 putative NAD(P) binding site [chemical binding]; other site 412694001872 EamA-like transporter family; Region: EamA; pfam00892 412694001873 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 412694001874 EamA-like transporter family; Region: EamA; pfam00892 412694001875 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 412694001876 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412694001877 DNA-binding site [nucleotide binding]; DNA binding site 412694001878 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412694001879 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694001880 homodimer interface [polypeptide binding]; other site 412694001881 catalytic residue [active] 412694001882 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 412694001883 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694001884 Coenzyme A binding pocket [chemical binding]; other site 412694001885 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412694001886 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412694001887 dimerization interface [polypeptide binding]; other site 412694001888 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694001889 dimer interface [polypeptide binding]; other site 412694001890 phosphorylation site [posttranslational modification] 412694001891 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694001892 ATP binding site [chemical binding]; other site 412694001893 Mg2+ binding site [ion binding]; other site 412694001894 G-X-G motif; other site 412694001895 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412694001896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694001897 active site 412694001898 phosphorylation site [posttranslational modification] 412694001899 intermolecular recognition site; other site 412694001900 dimerization interface [polypeptide binding]; other site 412694001901 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412694001902 DNA binding site [nucleotide binding] 412694001903 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 412694001904 Arrestin_N terminal like; Region: LDB19; pfam13002 412694001905 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694001906 Coenzyme A binding pocket [chemical binding]; other site 412694001907 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 412694001908 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 412694001909 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 412694001910 catalytic loop [active] 412694001911 iron binding site [ion binding]; other site 412694001912 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 412694001913 4Fe-4S binding domain; Region: Fer4; pfam00037 412694001914 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 412694001915 [4Fe-4S] binding site [ion binding]; other site 412694001916 molybdopterin cofactor binding site; other site 412694001917 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 412694001918 molybdopterin cofactor binding site; other site 412694001919 Uncharacterized conserved protein [Function unknown]; Region: COG2427 412694001920 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 412694001921 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 412694001922 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 412694001923 putative active site [active] 412694001924 catalytic site [active] 412694001925 putative metal binding site [ion binding]; other site 412694001926 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 412694001927 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 412694001928 hexamer interface [polypeptide binding]; other site 412694001929 ligand binding site [chemical binding]; other site 412694001930 putative active site [active] 412694001931 NAD(P) binding site [chemical binding]; other site 412694001932 amino acid transporter; Region: 2A0306; TIGR00909 412694001933 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 412694001934 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412694001935 dimerization interface [polypeptide binding]; other site 412694001936 putative DNA binding site [nucleotide binding]; other site 412694001937 putative Zn2+ binding site [ion binding]; other site 412694001938 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 412694001939 metal-binding site [ion binding] 412694001940 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 412694001941 Heavy-metal-associated domain; Region: HMA; pfam00403 412694001942 metal-binding site [ion binding] 412694001943 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 412694001944 Soluble P-type ATPase [General function prediction only]; Region: COG4087 412694001945 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 412694001946 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 412694001947 active site 412694001948 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412694001949 non-specific DNA binding site [nucleotide binding]; other site 412694001950 salt bridge; other site 412694001951 sequence-specific DNA binding site [nucleotide binding]; other site 412694001952 Tetratricopeptide repeat; Region: TPR_12; pfam13424 412694001953 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412694001954 binding surface 412694001955 TPR motif; other site 412694001956 Tetratricopeptide repeat; Region: TPR_12; pfam13424 412694001957 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 412694001958 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 412694001959 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 412694001960 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 412694001961 active site 412694001962 Zn binding site [ion binding]; other site 412694001963 Uncharacterized conserved protein [Function unknown]; Region: COG0398 412694001964 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 412694001965 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 412694001966 VanW like protein; Region: VanW; pfam04294 412694001967 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 412694001968 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 412694001969 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 412694001970 Nucleoside recognition; Region: Gate; pfam07670 412694001971 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 412694001972 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 412694001973 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 412694001974 putative metal binding site [ion binding]; other site 412694001975 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 412694001976 Domain of unknown function DUF21; Region: DUF21; pfam01595 412694001977 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 412694001978 Transporter associated domain; Region: CorC_HlyC; smart01091 412694001979 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 412694001980 Aspartase; Region: Aspartase; cd01357 412694001981 active sites [active] 412694001982 tetramer interface [polypeptide binding]; other site 412694001983 L-lactate permease; Region: Lactate_perm; cl00701 412694001984 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 412694001985 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412694001986 dimerization interface [polypeptide binding]; other site 412694001987 putative Zn2+ binding site [ion binding]; other site 412694001988 putative DNA binding site [nucleotide binding]; other site 412694001989 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 412694001990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694001991 putative substrate translocation pore; other site 412694001992 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 412694001993 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 412694001994 siderophore binding site; other site 412694001995 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 412694001996 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 412694001997 ABC-ATPase subunit interface; other site 412694001998 dimer interface [polypeptide binding]; other site 412694001999 putative PBP binding regions; other site 412694002000 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 412694002001 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 412694002002 ABC-ATPase subunit interface; other site 412694002003 dimer interface [polypeptide binding]; other site 412694002004 putative PBP binding regions; other site 412694002005 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 412694002006 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 412694002007 Walker A/P-loop; other site 412694002008 ATP binding site [chemical binding]; other site 412694002009 Q-loop/lid; other site 412694002010 ABC transporter signature motif; other site 412694002011 Walker B; other site 412694002012 D-loop; other site 412694002013 H-loop/switch region; other site 412694002014 Methyltransferase domain; Region: Methyltransf_31; pfam13847 412694002015 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694002016 S-adenosylmethionine binding site [chemical binding]; other site 412694002017 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 412694002018 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 412694002019 substrate-cofactor binding pocket; other site 412694002020 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694002021 catalytic residue [active] 412694002022 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 412694002023 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 412694002024 NAD binding site [chemical binding]; other site 412694002025 homodimer interface [polypeptide binding]; other site 412694002026 active site 412694002027 putative substrate binding site [chemical binding]; other site 412694002028 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 412694002029 nudix motif; other site 412694002030 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 412694002031 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 412694002032 metal ion-dependent adhesion site (MIDAS); other site 412694002033 MoxR-like ATPases [General function prediction only]; Region: COG0714 412694002034 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412694002035 Walker A motif; other site 412694002036 ATP binding site [chemical binding]; other site 412694002037 Walker B motif; other site 412694002038 arginine finger; other site 412694002039 cardiolipin synthetase; Reviewed; Region: PRK12452 412694002040 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 412694002041 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 412694002042 putative active site [active] 412694002043 catalytic site [active] 412694002044 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 412694002045 putative active site [active] 412694002046 catalytic site [active] 412694002047 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 412694002048 PAS domain; Region: PAS_9; pfam13426 412694002049 putative active site [active] 412694002050 heme pocket [chemical binding]; other site 412694002051 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 412694002052 metal binding site [ion binding]; metal-binding site 412694002053 active site 412694002054 I-site; other site 412694002055 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 412694002056 Amino acid permease; Region: AA_permease_2; pfam13520 412694002057 Spore germination protein; Region: Spore_permease; cl17796 412694002058 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412694002059 DNA-binding site [nucleotide binding]; DNA binding site 412694002060 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 412694002061 UTRA domain; Region: UTRA; pfam07702 412694002062 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 412694002063 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 412694002064 active site turn [active] 412694002065 phosphorylation site [posttranslational modification] 412694002066 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 412694002067 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 412694002068 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 412694002069 Ca binding site [ion binding]; other site 412694002070 active site 412694002071 catalytic site [active] 412694002072 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 412694002073 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 412694002074 Spore germination protein; Region: Spore_permease; cl17796 412694002075 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 412694002076 GAF domain; Region: GAF_3; pfam13492 412694002077 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 412694002078 Histidine kinase; Region: HisKA_3; pfam07730 412694002079 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694002080 ATP binding site [chemical binding]; other site 412694002081 Mg2+ binding site [ion binding]; other site 412694002082 G-X-G motif; other site 412694002083 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 412694002084 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694002085 active site 412694002086 phosphorylation site [posttranslational modification] 412694002087 intermolecular recognition site; other site 412694002088 dimerization interface [polypeptide binding]; other site 412694002089 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 412694002090 DNA binding residues [nucleotide binding] 412694002091 dimerization interface [polypeptide binding]; other site 412694002092 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 412694002093 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 412694002094 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 412694002095 putative active site [active] 412694002096 catalytic triad [active] 412694002097 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 412694002098 PA/protease domain interface [polypeptide binding]; other site 412694002099 putative integrin binding motif; other site 412694002100 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 412694002101 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 412694002102 dockerin binding interface; other site 412694002103 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 412694002104 CAAX protease self-immunity; Region: Abi; pfam02517 412694002105 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 412694002106 active site 412694002107 ATP binding site [chemical binding]; other site 412694002108 substrate binding site [chemical binding]; other site 412694002109 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 412694002110 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 412694002111 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 412694002112 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 412694002113 Walker A/P-loop; other site 412694002114 ATP binding site [chemical binding]; other site 412694002115 Q-loop/lid; other site 412694002116 ABC transporter signature motif; other site 412694002117 Walker B; other site 412694002118 D-loop; other site 412694002119 H-loop/switch region; other site 412694002120 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 412694002121 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 412694002122 substrate binding pocket [chemical binding]; other site 412694002123 membrane-bound complex binding site; other site 412694002124 hinge residues; other site 412694002125 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 412694002126 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694002127 dimer interface [polypeptide binding]; other site 412694002128 conserved gate region; other site 412694002129 putative PBP binding loops; other site 412694002130 ABC-ATPase subunit interface; other site 412694002131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694002132 dimer interface [polypeptide binding]; other site 412694002133 conserved gate region; other site 412694002134 putative PBP binding loops; other site 412694002135 ABC-ATPase subunit interface; other site 412694002136 S-methylmethionine transporter; Provisional; Region: PRK11387 412694002137 OsmC-like protein; Region: OsmC; pfam02566 412694002138 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 412694002139 nucleotide binding site/active site [active] 412694002140 HIT family signature motif; other site 412694002141 catalytic residue [active] 412694002142 RNA polymerase sigma factor; Provisional; Region: PRK12542 412694002143 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412694002144 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 412694002145 DNA binding residues [nucleotide binding] 412694002146 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 412694002147 Predicted transcriptional regulator [Transcription]; Region: COG2378 412694002148 HTH domain; Region: HTH_11; pfam08279 412694002149 WYL domain; Region: WYL; pfam13280 412694002150 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 412694002151 RibD C-terminal domain; Region: RibD_C; cl17279 412694002152 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412694002153 dimerization interface [polypeptide binding]; other site 412694002154 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694002155 dimer interface [polypeptide binding]; other site 412694002156 phosphorylation site [posttranslational modification] 412694002157 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694002158 ATP binding site [chemical binding]; other site 412694002159 Mg2+ binding site [ion binding]; other site 412694002160 G-X-G motif; other site 412694002161 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412694002162 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694002163 active site 412694002164 phosphorylation site [posttranslational modification] 412694002165 intermolecular recognition site; other site 412694002166 dimerization interface [polypeptide binding]; other site 412694002167 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412694002168 DNA binding site [nucleotide binding] 412694002169 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 412694002170 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 412694002171 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 412694002172 Sulfate transporter family; Region: Sulfate_transp; pfam00916 412694002173 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 412694002174 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 412694002175 Ligand Binding Site [chemical binding]; other site 412694002176 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 412694002177 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 412694002178 peptide binding site [polypeptide binding]; other site 412694002179 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 412694002180 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694002181 dimer interface [polypeptide binding]; other site 412694002182 conserved gate region; other site 412694002183 putative PBP binding loops; other site 412694002184 ABC-ATPase subunit interface; other site 412694002185 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 412694002186 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694002187 putative PBP binding loops; other site 412694002188 ABC-ATPase subunit interface; other site 412694002189 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 412694002190 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 412694002191 Walker A/P-loop; other site 412694002192 ATP binding site [chemical binding]; other site 412694002193 Q-loop/lid; other site 412694002194 ABC transporter signature motif; other site 412694002195 Walker B; other site 412694002196 D-loop; other site 412694002197 H-loop/switch region; other site 412694002198 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 412694002199 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 412694002200 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 412694002201 Walker A/P-loop; other site 412694002202 ATP binding site [chemical binding]; other site 412694002203 Q-loop/lid; other site 412694002204 ABC transporter signature motif; other site 412694002205 Walker B; other site 412694002206 D-loop; other site 412694002207 H-loop/switch region; other site 412694002208 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 412694002209 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 412694002210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694002211 putative substrate translocation pore; other site 412694002212 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 412694002213 MarR family; Region: MarR; pfam01047 412694002214 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 412694002215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694002216 putative substrate translocation pore; other site 412694002217 Transcriptional regulators [Transcription]; Region: PurR; COG1609 412694002218 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 412694002219 DNA binding site [nucleotide binding] 412694002220 domain linker motif; other site 412694002221 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 412694002222 dimerization interface [polypeptide binding]; other site 412694002223 ligand binding site [chemical binding]; other site 412694002224 sodium binding site [ion binding]; other site 412694002225 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 412694002226 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 412694002227 substrate binding site [chemical binding]; other site 412694002228 dimer interface [polypeptide binding]; other site 412694002229 ATP binding site [chemical binding]; other site 412694002230 D-ribose pyranase; Provisional; Region: PRK11797 412694002231 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 412694002232 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 412694002233 Walker A/P-loop; other site 412694002234 ATP binding site [chemical binding]; other site 412694002235 Q-loop/lid; other site 412694002236 ABC transporter signature motif; other site 412694002237 Walker B; other site 412694002238 D-loop; other site 412694002239 H-loop/switch region; other site 412694002240 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 412694002241 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 412694002242 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 412694002243 TM-ABC transporter signature motif; other site 412694002244 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 412694002245 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 412694002246 ligand binding site [chemical binding]; other site 412694002247 dimerization interface [polypeptide binding]; other site 412694002248 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 412694002249 active site 412694002250 intersubunit interactions; other site 412694002251 catalytic residue [active] 412694002252 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 412694002253 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 412694002254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694002255 Major Facilitator Superfamily; Region: MFS_1; pfam07690 412694002256 putative substrate translocation pore; other site 412694002257 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 412694002258 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 412694002259 putative NAD(P) binding site [chemical binding]; other site 412694002260 catalytic Zn binding site [ion binding]; other site 412694002261 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 412694002262 Zn binding site [ion binding]; other site 412694002263 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 412694002264 putative catalytic site [active] 412694002265 metal binding site A [ion binding]; metal-binding site 412694002266 phosphate binding site [ion binding]; other site 412694002267 metal binding site C [ion binding]; metal-binding site 412694002268 metal binding site B [ion binding]; metal-binding site 412694002269 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 412694002270 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 412694002271 dimer interface [polypeptide binding]; other site 412694002272 active site 412694002273 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 412694002274 substrate binding site [chemical binding]; other site 412694002275 catalytic residue [active] 412694002276 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 412694002277 FAD binding domain; Region: FAD_binding_4; pfam01565 412694002278 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 412694002279 VanZ like family; Region: VanZ; pfam04892 412694002280 RDD family; Region: RDD; pfam06271 412694002281 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 412694002282 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 412694002283 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 412694002284 dimer interface [polypeptide binding]; other site 412694002285 putative CheW interface [polypeptide binding]; other site 412694002286 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 412694002287 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 412694002288 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 412694002289 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412694002290 non-specific DNA binding site [nucleotide binding]; other site 412694002291 salt bridge; other site 412694002292 sequence-specific DNA binding site [nucleotide binding]; other site 412694002293 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 412694002294 active site 412694002295 catalytic site [active] 412694002296 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 412694002297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694002298 putative substrate translocation pore; other site 412694002299 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 412694002300 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 412694002301 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 412694002302 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 412694002303 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 412694002304 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 412694002305 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 412694002306 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412694002307 non-specific DNA binding site [nucleotide binding]; other site 412694002308 salt bridge; other site 412694002309 sequence-specific DNA binding site [nucleotide binding]; other site 412694002310 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694002311 Coenzyme A binding pocket [chemical binding]; other site 412694002312 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 412694002313 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 412694002314 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 412694002315 TrkA-N domain; Region: TrkA_N; pfam02254 412694002316 TrkA-C domain; Region: TrkA_C; pfam02080 412694002317 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 412694002318 Subunit I/III interface [polypeptide binding]; other site 412694002319 Subunit III/IV interface [polypeptide binding]; other site 412694002320 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 412694002321 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 412694002322 D-pathway; other site 412694002323 Putative ubiquinol binding site [chemical binding]; other site 412694002324 Low-spin heme (heme b) binding site [chemical binding]; other site 412694002325 Putative water exit pathway; other site 412694002326 Binuclear center (heme o3/CuB) [ion binding]; other site 412694002327 K-pathway; other site 412694002328 Putative proton exit pathway; other site 412694002329 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 412694002330 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 412694002331 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 412694002332 putative active site [active] 412694002333 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 412694002334 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 412694002335 metal binding site [ion binding]; metal-binding site 412694002336 dimer interface [polypeptide binding]; other site 412694002337 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 412694002338 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 412694002339 Na binding site [ion binding]; other site 412694002340 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 412694002341 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 412694002342 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 412694002343 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 412694002344 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 412694002345 Nucleoside recognition; Region: Gate; pfam07670 412694002346 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 412694002347 Nucleoside recognition; Region: Gate; pfam07670 412694002348 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 412694002349 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 412694002350 G1 box; other site 412694002351 GTP/Mg2+ binding site [chemical binding]; other site 412694002352 Switch I region; other site 412694002353 G2 box; other site 412694002354 G3 box; other site 412694002355 Switch II region; other site 412694002356 G4 box; other site 412694002357 G5 box; other site 412694002358 FeoA domain; Region: FeoA; pfam04023 412694002359 phosphate binding protein; Region: ptsS_2; TIGR02136 412694002360 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 412694002361 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 412694002362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694002363 dimer interface [polypeptide binding]; other site 412694002364 conserved gate region; other site 412694002365 putative PBP binding loops; other site 412694002366 ABC-ATPase subunit interface; other site 412694002367 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 412694002368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694002369 dimer interface [polypeptide binding]; other site 412694002370 conserved gate region; other site 412694002371 putative PBP binding loops; other site 412694002372 ABC-ATPase subunit interface; other site 412694002373 AAA domain; Region: AAA_33; pfam13671 412694002374 AAA domain; Region: AAA_17; pfam13207 412694002375 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 412694002376 FOG: CBS domain [General function prediction only]; Region: COG0517 412694002377 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 412694002378 Domain of unknown function (DUF3960); Region: DUF3960; pfam13142 412694002379 Protein of unknown function (DUF3965); Region: DUF3965; pfam13112 412694002380 Bacterial SH3 domain; Region: SH3_3; pfam08239 412694002381 Bacterial SH3 domain; Region: SH3_3; pfam08239 412694002382 Bacterial SH3 domain; Region: SH3_3; pfam08239 412694002383 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 412694002384 Peptidase family M23; Region: Peptidase_M23; pfam01551 412694002385 Putative transcription activator [Transcription]; Region: TenA; COG0819 412694002386 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 412694002387 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 412694002388 Walker A/P-loop; other site 412694002389 ATP binding site [chemical binding]; other site 412694002390 Q-loop/lid; other site 412694002391 ABC transporter signature motif; other site 412694002392 Walker B; other site 412694002393 D-loop; other site 412694002394 H-loop/switch region; other site 412694002395 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 412694002396 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694002397 dimer interface [polypeptide binding]; other site 412694002398 conserved gate region; other site 412694002399 putative PBP binding loops; other site 412694002400 ABC-ATPase subunit interface; other site 412694002401 NMT1/THI5 like; Region: NMT1; pfam09084 412694002402 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 412694002403 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 412694002404 thiamine phosphate binding site [chemical binding]; other site 412694002405 active site 412694002406 pyrophosphate binding site [ion binding]; other site 412694002407 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 412694002408 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 412694002409 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 412694002410 thiS-thiF/thiG interaction site; other site 412694002411 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 412694002412 ThiS interaction site; other site 412694002413 putative active site [active] 412694002414 tetramer interface [polypeptide binding]; other site 412694002415 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 412694002416 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 412694002417 ATP binding site [chemical binding]; other site 412694002418 substrate interface [chemical binding]; other site 412694002419 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 412694002420 dimer interface [polypeptide binding]; other site 412694002421 substrate binding site [chemical binding]; other site 412694002422 ATP binding site [chemical binding]; other site 412694002423 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 412694002424 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 412694002425 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 412694002426 Soluble P-type ATPase [General function prediction only]; Region: COG4087 412694002427 potassium-transporting ATPase subunit C; Provisional; Region: PRK13997 412694002428 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 412694002429 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 412694002430 Ligand Binding Site [chemical binding]; other site 412694002431 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 412694002432 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694002433 putative substrate translocation pore; other site 412694002434 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 412694002435 MarR family; Region: MarR; pfam01047 412694002436 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 412694002437 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 412694002438 active site 412694002439 nucleophile elbow; other site 412694002440 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 412694002441 FtsX-like permease family; Region: FtsX; pfam02687 412694002442 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 412694002443 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 412694002444 FtsX-like permease family; Region: FtsX; pfam02687 412694002445 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 412694002446 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 412694002447 Walker A/P-loop; other site 412694002448 ATP binding site [chemical binding]; other site 412694002449 Q-loop/lid; other site 412694002450 ABC transporter signature motif; other site 412694002451 Walker B; other site 412694002452 D-loop; other site 412694002453 H-loop/switch region; other site 412694002454 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 412694002455 short chain dehydrogenase; Provisional; Region: PRK06701 412694002456 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 412694002457 NAD binding site [chemical binding]; other site 412694002458 metal binding site [ion binding]; metal-binding site 412694002459 active site 412694002460 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 412694002461 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 412694002462 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 412694002463 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 412694002464 putative substrate binding site [chemical binding]; other site 412694002465 putative ATP binding site [chemical binding]; other site 412694002466 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 412694002467 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 412694002468 substrate binding [chemical binding]; other site 412694002469 active site 412694002470 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 412694002471 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 412694002472 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 412694002473 active site turn [active] 412694002474 phosphorylation site [posttranslational modification] 412694002475 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 412694002476 Transcriptional regulators [Transcription]; Region: PurR; COG1609 412694002477 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 412694002478 DNA binding site [nucleotide binding] 412694002479 domain linker motif; other site 412694002480 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 412694002481 dimerization interface [polypeptide binding]; other site 412694002482 ligand binding site [chemical binding]; other site 412694002483 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 412694002484 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 412694002485 catalytic residues [active] 412694002486 YhdB-like protein; Region: YhdB; pfam14148 412694002487 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 412694002488 Spore germination protein; Region: Spore_permease; cl17796 412694002489 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 412694002490 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 412694002491 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 412694002492 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 412694002493 putative FMN binding site [chemical binding]; other site 412694002494 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 412694002495 SpoVR like protein; Region: SpoVR; pfam04293 412694002496 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 412694002497 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 412694002498 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 412694002499 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 412694002500 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 412694002501 active site residue [active] 412694002502 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 412694002503 putative homodimer interface [polypeptide binding]; other site 412694002504 putative homotetramer interface [polypeptide binding]; other site 412694002505 putative metal binding site [ion binding]; other site 412694002506 putative homodimer-homodimer interface [polypeptide binding]; other site 412694002507 putative allosteric switch controlling residues; other site 412694002508 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 412694002509 CPxP motif; other site 412694002510 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 412694002511 active site residue [active] 412694002512 Member of the Rhodanese Homology Domain superfamily. This CD includes predicted proteins with rhodanese-like domains found N-terminal of the metallo-beta-lactamase domain; Region: RHOD_Lact_B; cd01523 412694002513 active site residue [active] 412694002514 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 412694002515 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 412694002516 CPxP motif; other site 412694002517 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 412694002518 active site residue [active] 412694002519 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 412694002520 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 412694002521 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 412694002522 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 412694002523 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 412694002524 NADP binding site [chemical binding]; other site 412694002525 dimer interface [polypeptide binding]; other site 412694002526 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 412694002527 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 412694002528 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 412694002529 PhoU domain; Region: PhoU; pfam01895 412694002530 PhoU domain; Region: PhoU; pfam01895 412694002531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694002532 Major Facilitator Superfamily; Region: MFS_1; pfam07690 412694002533 putative substrate translocation pore; other site 412694002534 Uncharacterized conserved protein [Function unknown]; Region: COG3589 412694002535 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 412694002536 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 412694002537 HTH domain; Region: HTH_11; pfam08279 412694002538 Mga helix-turn-helix domain; Region: Mga; pfam05043 412694002539 PRD domain; Region: PRD; pfam00874 412694002540 PRD domain; Region: PRD; pfam00874 412694002541 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 412694002542 active site 412694002543 P-loop; other site 412694002544 phosphorylation site [posttranslational modification] 412694002545 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 412694002546 active site 412694002547 phosphorylation site [posttranslational modification] 412694002548 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 412694002549 active site 412694002550 methionine cluster; other site 412694002551 phosphorylation site [posttranslational modification] 412694002552 metal binding site [ion binding]; metal-binding site 412694002553 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 412694002554 active site 412694002555 P-loop; other site 412694002556 phosphorylation site [posttranslational modification] 412694002557 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 412694002558 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 412694002559 Uncharacterized conserved protein [Function unknown]; Region: COG3589 412694002560 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 412694002561 Bacterial SH3 domain; Region: SH3_3; pfam08239 412694002562 Bacterial SH3 domain; Region: SH3_3; pfam08239 412694002563 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 412694002564 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 412694002565 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 412694002566 FtsX-like permease family; Region: FtsX; pfam02687 412694002567 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 412694002568 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 412694002569 Walker A/P-loop; other site 412694002570 ATP binding site [chemical binding]; other site 412694002571 Q-loop/lid; other site 412694002572 ABC transporter signature motif; other site 412694002573 Walker B; other site 412694002574 D-loop; other site 412694002575 H-loop/switch region; other site 412694002576 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 412694002577 HlyD family secretion protein; Region: HlyD_3; pfam13437 412694002578 conserved hypothetical integral membrane protein TIGR02206; Region: intg_mem_TP0381 412694002579 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 412694002580 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 412694002581 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 412694002582 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694002583 dimer interface [polypeptide binding]; other site 412694002584 conserved gate region; other site 412694002585 ABC-ATPase subunit interface; other site 412694002586 FtsX-like permease family; Region: FtsX; pfam02687 412694002587 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 412694002588 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 412694002589 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 412694002590 dimanganese center [ion binding]; other site 412694002591 CotJB protein; Region: CotJB; pfam12652 412694002592 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 412694002593 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 412694002594 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 412694002595 active site 412694002596 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 412694002597 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 412694002598 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 412694002599 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 412694002600 putative DNA binding site [nucleotide binding]; other site 412694002601 putative homodimer interface [polypeptide binding]; other site 412694002602 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 412694002603 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 412694002604 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 412694002605 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 412694002606 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 412694002607 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 412694002608 active site 412694002609 metal binding site [ion binding]; metal-binding site 412694002610 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 412694002611 Interdomain contacts; other site 412694002612 Cytokine receptor motif; other site 412694002613 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 412694002614 amino acid transporter; Region: 2A0306; TIGR00909 412694002615 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 412694002616 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 412694002617 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 412694002618 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 412694002619 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 412694002620 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 412694002621 putative active site [active] 412694002622 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 412694002623 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 412694002624 putative active site [active] 412694002625 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 412694002626 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 412694002627 active site turn [active] 412694002628 phosphorylation site [posttranslational modification] 412694002629 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 412694002630 Probable transposase; Region: OrfB_IS605; pfam01385 412694002631 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 412694002632 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 412694002633 Uncharacterized conserved protein [Function unknown]; Region: COG3589 412694002634 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 412694002635 DoxX; Region: DoxX; pfam07681 412694002636 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 412694002637 hypothetical protein; Provisional; Region: PRK06770 412694002638 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 412694002639 EamA-like transporter family; Region: EamA; pfam00892 412694002640 EamA-like transporter family; Region: EamA; pfam00892 412694002641 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 412694002642 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 412694002643 AsnC family; Region: AsnC_trans_reg; pfam01037 412694002644 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694002645 Coenzyme A binding pocket [chemical binding]; other site 412694002646 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 412694002647 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 412694002648 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412694002649 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412694002650 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694002651 Major Facilitator Superfamily; Region: MFS_1; pfam07690 412694002652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694002653 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 412694002654 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 412694002655 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 412694002656 Major Facilitator Superfamily; Region: MFS_1; pfam07690 412694002657 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694002658 putative substrate translocation pore; other site 412694002659 intracellular protease, PfpI family; Region: PfpI; TIGR01382 412694002660 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 412694002661 proposed catalytic triad [active] 412694002662 conserved cys residue [active] 412694002663 hydroperoxidase II; Provisional; Region: katE; PRK11249 412694002664 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 412694002665 tetramer interface [polypeptide binding]; other site 412694002666 heme binding pocket [chemical binding]; other site 412694002667 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 412694002668 domain interactions; other site 412694002669 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 412694002670 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 412694002671 Spore germination protein; Region: Spore_permease; cl17796 412694002672 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 412694002673 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 412694002674 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 412694002675 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 412694002676 tetrameric interface [polypeptide binding]; other site 412694002677 activator binding site; other site 412694002678 NADP binding site [chemical binding]; other site 412694002679 substrate binding site [chemical binding]; other site 412694002680 catalytic residues [active] 412694002681 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 412694002682 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 412694002683 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412694002684 Walker A/P-loop; other site 412694002685 ATP binding site [chemical binding]; other site 412694002686 Q-loop/lid; other site 412694002687 ABC transporter signature motif; other site 412694002688 Walker B; other site 412694002689 D-loop; other site 412694002690 H-loop/switch region; other site 412694002691 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 412694002692 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 412694002693 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 412694002694 Walker A/P-loop; other site 412694002695 ATP binding site [chemical binding]; other site 412694002696 Q-loop/lid; other site 412694002697 ABC transporter signature motif; other site 412694002698 Walker B; other site 412694002699 D-loop; other site 412694002700 H-loop/switch region; other site 412694002701 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 412694002702 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 412694002703 substrate binding pocket [chemical binding]; other site 412694002704 membrane-bound complex binding site; other site 412694002705 hinge residues; other site 412694002706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694002707 dimer interface [polypeptide binding]; other site 412694002708 conserved gate region; other site 412694002709 putative PBP binding loops; other site 412694002710 ABC-ATPase subunit interface; other site 412694002711 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 412694002712 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 412694002713 Walker A/P-loop; other site 412694002714 ATP binding site [chemical binding]; other site 412694002715 Q-loop/lid; other site 412694002716 ABC transporter signature motif; other site 412694002717 Walker B; other site 412694002718 D-loop; other site 412694002719 H-loop/switch region; other site 412694002720 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 412694002721 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 412694002722 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 412694002723 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 412694002724 hypothetical protein; Provisional; Region: PRK13676 412694002725 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 412694002726 acetolactate synthase; Reviewed; Region: PRK08617 412694002727 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 412694002728 PYR/PP interface [polypeptide binding]; other site 412694002729 dimer interface [polypeptide binding]; other site 412694002730 TPP binding site [chemical binding]; other site 412694002731 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 412694002732 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 412694002733 TPP-binding site [chemical binding]; other site 412694002734 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 412694002735 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 412694002736 active site 412694002737 DNA binding site [nucleotide binding] 412694002738 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 412694002739 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 412694002740 active site 412694002741 motif I; other site 412694002742 motif II; other site 412694002743 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412694002744 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 412694002745 amidase catalytic site [active] 412694002746 Zn binding residues [ion binding]; other site 412694002747 substrate binding site [chemical binding]; other site 412694002748 S-layer homology domain; Region: SLH; pfam00395 412694002749 S-layer homology domain; Region: SLH; pfam00395 412694002750 S-layer homology domain; Region: SLH; pfam00395 412694002751 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 412694002752 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 412694002753 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 412694002754 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 412694002755 acyl-activating enzyme (AAE) consensus motif; other site 412694002756 acyl-activating enzyme (AAE) consensus motif; other site 412694002757 putative AMP binding site [chemical binding]; other site 412694002758 putative active site [active] 412694002759 putative CoA binding site [chemical binding]; other site 412694002760 high affinity sulphate transporter 1; Region: sulP; TIGR00815 412694002761 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 412694002762 Sulfate transporter family; Region: Sulfate_transp; pfam00916 412694002763 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 412694002764 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 412694002765 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 412694002766 ATP binding site [chemical binding]; other site 412694002767 putative Mg++ binding site [ion binding]; other site 412694002768 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 412694002769 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412694002770 nucleotide binding region [chemical binding]; other site 412694002771 ATP-binding site [chemical binding]; other site 412694002772 stage V sporulation protein B; Region: spore_V_B; TIGR02900 412694002773 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 412694002774 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 412694002775 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 412694002776 S-layer homology domain; Region: SLH; pfam00395 412694002777 S-layer homology domain; Region: SLH; pfam00395 412694002778 S-layer homology domain; Region: SLH; pfam00395 412694002779 S-layer homology domain; Region: SLH; pfam00395 412694002780 S-layer homology domain; Region: SLH; pfam00395 412694002781 S-layer homology domain; Region: SLH; pfam00395 412694002782 DHHW protein; Region: DHHW; pfam14286 412694002783 DHHW protein; Region: DHHW; pfam14286 412694002784 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 412694002785 enoyl-CoA hydratase; Provisional; Region: PRK07659 412694002786 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 412694002787 substrate binding site [chemical binding]; other site 412694002788 oxyanion hole (OAH) forming residues; other site 412694002789 trimer interface [polypeptide binding]; other site 412694002790 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 412694002791 metal binding site [ion binding]; metal-binding site 412694002792 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 412694002793 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 412694002794 putative oligomer interface [polypeptide binding]; other site 412694002795 putative active site [active] 412694002796 metal binding site [ion binding]; metal-binding site 412694002797 S-layer homology domain; Region: SLH; pfam00395 412694002798 S-layer homology domain; Region: SLH; pfam00395 412694002799 S-layer homology domain; Region: SLH; pfam00395 412694002800 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 412694002801 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 412694002802 active site 412694002803 metal binding site [ion binding]; metal-binding site 412694002804 Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041 412694002805 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694002806 S-adenosylmethionine binding site [chemical binding]; other site 412694002807 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 412694002808 proline racemase; Provisional; Region: PRK13969 412694002809 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 412694002810 ornithine cyclodeaminase; Validated; Region: PRK08618 412694002811 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 412694002812 NAD(P) binding site [chemical binding]; other site 412694002813 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 412694002814 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 412694002815 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 412694002816 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694002817 dimer interface [polypeptide binding]; other site 412694002818 conserved gate region; other site 412694002819 putative PBP binding loops; other site 412694002820 ABC-ATPase subunit interface; other site 412694002821 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 412694002822 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 412694002823 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694002824 dimer interface [polypeptide binding]; other site 412694002825 conserved gate region; other site 412694002826 putative PBP binding loops; other site 412694002827 ABC-ATPase subunit interface; other site 412694002828 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 412694002829 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 412694002830 Walker A/P-loop; other site 412694002831 ATP binding site [chemical binding]; other site 412694002832 Q-loop/lid; other site 412694002833 ABC transporter signature motif; other site 412694002834 Walker B; other site 412694002835 D-loop; other site 412694002836 H-loop/switch region; other site 412694002837 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 412694002838 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 412694002839 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 412694002840 Walker A/P-loop; other site 412694002841 ATP binding site [chemical binding]; other site 412694002842 Q-loop/lid; other site 412694002843 ABC transporter signature motif; other site 412694002844 Walker B; other site 412694002845 D-loop; other site 412694002846 H-loop/switch region; other site 412694002847 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 412694002848 Predicted transcriptional regulator [Transcription]; Region: COG2378 412694002849 WYL domain; Region: WYL; pfam13280 412694002850 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 412694002851 Dynamin family; Region: Dynamin_N; pfam00350 412694002852 G1 box; other site 412694002853 GTP/Mg2+ binding site [chemical binding]; other site 412694002854 G2 box; other site 412694002855 Switch I region; other site 412694002856 G3 box; other site 412694002857 Switch II region; other site 412694002858 G4 box; other site 412694002859 G5 box; other site 412694002860 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 412694002861 Dynamin family; Region: Dynamin_N; pfam00350 412694002862 G1 box; other site 412694002863 GTP/Mg2+ binding site [chemical binding]; other site 412694002864 G2 box; other site 412694002865 Switch I region; other site 412694002866 G3 box; other site 412694002867 Switch II region; other site 412694002868 G4 box; other site 412694002869 G5 box; other site 412694002870 Domain of unknown function DUF87; Region: DUF87; pfam01935 412694002871 AAA-like domain; Region: AAA_10; pfam12846 412694002872 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 412694002873 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 412694002874 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 412694002875 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694002876 putative substrate translocation pore; other site 412694002877 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 412694002878 PAS domain; Region: PAS; smart00091 412694002879 putative active site [active] 412694002880 heme pocket [chemical binding]; other site 412694002881 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694002882 ATP binding site [chemical binding]; other site 412694002883 Mg2+ binding site [ion binding]; other site 412694002884 G-X-G motif; other site 412694002885 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 412694002886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694002887 active site 412694002888 phosphorylation site [posttranslational modification] 412694002889 intermolecular recognition site; other site 412694002890 dimerization interface [polypeptide binding]; other site 412694002891 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 412694002892 Protein of unknown function (DUF3962); Region: DUF3962; pfam13111 412694002893 Domain of unknown function (DUF3893); Region: DUF3893; pfam13032 412694002894 Predicted transcriptional regulator [Transcription]; Region: COG2378 412694002895 WYL domain; Region: WYL; pfam13280 412694002896 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 412694002897 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 412694002898 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 412694002899 Protein of unknown function (DUF524); Region: DUF524; pfam04411 412694002900 T5orf172 domain; Region: T5orf172; cl17462 412694002901 DEAD-like helicases superfamily; Region: DEXDc; smart00487 412694002902 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 412694002903 ATP binding site [chemical binding]; other site 412694002904 putative Mg++ binding site [ion binding]; other site 412694002905 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 412694002906 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 412694002907 replicative DNA helicase; Provisional; Region: PRK06749 412694002908 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 412694002909 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 412694002910 Walker A motif; other site 412694002911 ATP binding site [chemical binding]; other site 412694002912 Walker B motif; other site 412694002913 DNA binding loops [nucleotide binding] 412694002914 Predicted transcriptional regulators [Transcription]; Region: COG1378 412694002915 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 412694002916 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 412694002917 C-terminal domain interface [polypeptide binding]; other site 412694002918 sugar binding site [chemical binding]; other site 412694002919 hypothetical protein; Provisional; Region: PRK10621 412694002920 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 412694002921 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412694002922 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412694002923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694002924 putative substrate translocation pore; other site 412694002925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694002926 Predicted permease; Region: DUF318; cl17795 412694002927 Predicted transcriptional regulators [Transcription]; Region: COG1695 412694002928 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 412694002929 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 412694002930 nucleophilic elbow; other site 412694002931 catalytic triad; other site 412694002932 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 412694002933 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 412694002934 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 412694002935 CGNR zinc finger; Region: zf-CGNR; pfam11706 412694002936 HPP family; Region: HPP; pfam04982 412694002937 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 412694002938 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 412694002939 putative NAD(P) binding site [chemical binding]; other site 412694002940 active site 412694002941 putative substrate binding site [chemical binding]; other site 412694002942 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 412694002943 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412694002944 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412694002945 YmzC-like protein; Region: YmzC; pfam14157 412694002946 Transcriptional regulators [Transcription]; Region: MarR; COG1846 412694002947 MarR family; Region: MarR_2; pfam12802 412694002948 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 412694002949 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 412694002950 VanZ like family; Region: VanZ; pfam04892 412694002951 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 412694002952 DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483 412694002953 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 412694002954 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 412694002955 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412694002956 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 412694002957 dihydroxyacetone kinase; Provisional; Region: PRK14479 412694002958 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 412694002959 DAK2 domain; Region: Dak2; pfam02734 412694002960 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 412694002961 Predicted transcriptional regulator [Transcription]; Region: COG1959 412694002962 Transcriptional regulator; Region: Rrf2; pfam02082 412694002963 DAK2 domain; Region: Dak2; pfam02734 412694002964 Tetratricopeptide repeat; Region: TPR_12; pfam13424 412694002965 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 412694002966 TPR motif; other site 412694002967 binding surface 412694002968 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 412694002969 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 412694002970 Zn2+ binding site [ion binding]; other site 412694002971 Mg2+ binding site [ion binding]; other site 412694002972 S-layer homology domain; Region: SLH; pfam00395 412694002973 S-layer homology domain; Region: SLH; pfam00395 412694002974 S-layer homology domain; Region: SLH; pfam00395 412694002975 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 412694002976 Predicted transcriptional regulators [Transcription]; Region: COG1695 412694002977 Transcriptional regulator PadR-like family; Region: PadR; cl17335 412694002978 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 412694002979 Heat induced stress protein YflT; Region: YflT; pfam11181 412694002980 CsbD-like; Region: CsbD; cl17424 412694002981 Predicted membrane protein [Function unknown]; Region: COG2261 412694002982 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 412694002983 anti sigma factor interaction site; other site 412694002984 regulatory phosphorylation site [posttranslational modification]; other site 412694002985 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 412694002986 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694002987 ATP binding site [chemical binding]; other site 412694002988 Mg2+ binding site [ion binding]; other site 412694002989 G-X-G motif; other site 412694002990 RNA polymerase sigma-B factor; Region: Sigma_B; TIGR02941 412694002991 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412694002992 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 412694002993 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 412694002994 DNA binding residues [nucleotide binding] 412694002995 Ferritin-like domain; Region: Ferritin; pfam00210 412694002996 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 412694002997 dinuclear metal binding motif [ion binding]; other site 412694002998 Response regulator receiver domain; Region: Response_reg; pfam00072 412694002999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694003000 active site 412694003001 phosphorylation site [posttranslational modification] 412694003002 intermolecular recognition site; other site 412694003003 dimerization interface [polypeptide binding]; other site 412694003004 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 412694003005 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 412694003006 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 412694003007 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 412694003008 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 412694003009 CHASE3 domain; Region: CHASE3; pfam05227 412694003010 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 412694003011 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 412694003012 GAF domain; Region: GAF; pfam01590 412694003013 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412694003014 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694003015 dimer interface [polypeptide binding]; other site 412694003016 phosphorylation site [posttranslational modification] 412694003017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694003018 ATP binding site [chemical binding]; other site 412694003019 Mg2+ binding site [ion binding]; other site 412694003020 G-X-G motif; other site 412694003021 Response regulator receiver domain; Region: Response_reg; pfam00072 412694003022 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694003023 active site 412694003024 phosphorylation site [posttranslational modification] 412694003025 intermolecular recognition site; other site 412694003026 dimerization interface [polypeptide binding]; other site 412694003027 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 412694003028 Protein of unknown function (DUF4028); Region: DUF4028; pfam13220 412694003029 hypothetical protein; Provisional; Region: PRK12856 412694003030 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 412694003031 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 412694003032 NADP binding site [chemical binding]; other site 412694003033 dimer interface [polypeptide binding]; other site 412694003034 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412694003035 Histidine kinase; Region: HisKA_3; pfam07730 412694003036 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694003037 ATP binding site [chemical binding]; other site 412694003038 Mg2+ binding site [ion binding]; other site 412694003039 G-X-G motif; other site 412694003040 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 412694003041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694003042 active site 412694003043 phosphorylation site [posttranslational modification] 412694003044 intermolecular recognition site; other site 412694003045 dimerization interface [polypeptide binding]; other site 412694003046 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 412694003047 DNA binding residues [nucleotide binding] 412694003048 dimerization interface [polypeptide binding]; other site 412694003049 YhzD-like protein; Region: YhzD; pfam14120 412694003050 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 412694003051 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 412694003052 active site 412694003053 metal binding site [ion binding]; metal-binding site 412694003054 DNA binding site [nucleotide binding] 412694003055 AAA domain; Region: AAA_27; pfam13514 412694003056 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412694003057 Q-loop/lid; other site 412694003058 ABC transporter signature motif; other site 412694003059 Walker B; other site 412694003060 D-loop; other site 412694003061 H-loop/switch region; other site 412694003062 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 412694003063 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 412694003064 generic binding surface I; other site 412694003065 generic binding surface II; other site 412694003066 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 412694003067 Zn2+ binding site [ion binding]; other site 412694003068 Mg2+ binding site [ion binding]; other site 412694003069 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 412694003070 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 412694003071 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 412694003072 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 412694003073 Zn binding site [ion binding]; other site 412694003074 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 412694003075 Zn binding site [ion binding]; other site 412694003076 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 412694003077 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 412694003078 Zn binding site [ion binding]; other site 412694003079 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 412694003080 Zn binding site [ion binding]; other site 412694003081 Tetratricopeptide repeat; Region: TPR_12; pfam13424 412694003082 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412694003083 TPR motif; other site 412694003084 binding surface 412694003085 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 412694003086 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 412694003087 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 412694003088 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 412694003089 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 412694003090 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 412694003091 amphipathic channel; other site 412694003092 Asn-Pro-Ala signature motifs; other site 412694003093 glycerol kinase; Provisional; Region: glpK; PRK00047 412694003094 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 412694003095 N- and C-terminal domain interface [polypeptide binding]; other site 412694003096 active site 412694003097 MgATP binding site [chemical binding]; other site 412694003098 catalytic site [active] 412694003099 metal binding site [ion binding]; metal-binding site 412694003100 glycerol binding site [chemical binding]; other site 412694003101 homotetramer interface [polypeptide binding]; other site 412694003102 homodimer interface [polypeptide binding]; other site 412694003103 FBP binding site [chemical binding]; other site 412694003104 protein IIAGlc interface [polypeptide binding]; other site 412694003105 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 412694003106 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 412694003107 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 412694003108 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412694003109 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 412694003110 DNA binding residues [nucleotide binding] 412694003111 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 412694003112 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 412694003113 MarR family; Region: MarR; pfam01047 412694003114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694003115 putative substrate translocation pore; other site 412694003116 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 412694003117 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694003118 putative substrate translocation pore; other site 412694003119 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 412694003120 Part of AAA domain; Region: AAA_19; pfam13245 412694003121 Family description; Region: UvrD_C_2; pfam13538 412694003122 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 412694003123 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 412694003124 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 412694003125 transcriptional regulator Hpr; Provisional; Region: PRK13777 412694003126 MarR family; Region: MarR; pfam01047 412694003127 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 412694003128 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 412694003129 HIT family signature motif; other site 412694003130 catalytic residue [active] 412694003131 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 412694003132 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 412694003133 Walker A/P-loop; other site 412694003134 ATP binding site [chemical binding]; other site 412694003135 Q-loop/lid; other site 412694003136 ABC transporter signature motif; other site 412694003137 Walker B; other site 412694003138 D-loop; other site 412694003139 H-loop/switch region; other site 412694003140 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 412694003141 EcsC protein family; Region: EcsC; pfam12787 412694003142 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412694003143 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412694003144 Predicted membrane protein [Function unknown]; Region: COG3428 412694003145 Bacterial PH domain; Region: DUF304; pfam03703 412694003146 Bacterial PH domain; Region: DUF304; pfam03703 412694003147 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 412694003148 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412694003149 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412694003150 Collagen binding domain; Region: Collagen_bind; pfam05737 412694003151 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 412694003152 Cna protein B-type domain; Region: Cna_B; pfam05738 412694003153 Cna protein B-type domain; Region: Cna_B; pfam05738 412694003154 Cna protein B-type domain; Region: Cna_B; pfam05738 412694003155 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 412694003156 Cna protein B-type domain; Region: Cna_B; pfam05738 412694003157 Cna protein B-type domain; Region: Cna_B; pfam05738 412694003158 Cna protein B-type domain; Region: Cna_B; pfam05738 412694003159 Cna protein B-type domain; Region: Cna_B; pfam05738 412694003160 Cna protein B-type domain; Region: Cna_B; pfam05738 412694003161 Cna protein B-type domain; Region: Cna_B; pfam05738 412694003162 Cna protein B-type domain; Region: Cna_B; pfam05738 412694003163 Cna protein B-type domain; Region: Cna_B; pfam05738 412694003164 Uncharacterized conserved protein [Function unknown]; Region: COG3402 412694003165 Predicted membrane protein [Function unknown]; Region: COG3428 412694003166 Bacterial PH domain; Region: DUF304; pfam03703 412694003167 Bacterial PH domain; Region: DUF304; pfam03703 412694003168 Bacterial PH domain; Region: DUF304; pfam03703 412694003169 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 412694003170 Transglycosylase; Region: Transgly; pfam00912 412694003171 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 412694003172 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 412694003173 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 412694003174 substrate binding site [chemical binding]; other site 412694003175 active site 412694003176 ferrochelatase; Provisional; Region: PRK12435 412694003177 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 412694003178 C-terminal domain interface [polypeptide binding]; other site 412694003179 active site 412694003180 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 412694003181 active site 412694003182 N-terminal domain interface [polypeptide binding]; other site 412694003183 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 412694003184 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 412694003185 Protein of unknown function (DUF4026); Region: DUF4026; pfam13218 412694003186 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 412694003187 Fn3 associated; Region: Fn3_assoc; pfam13287 412694003188 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 412694003189 generic binding surface II; other site 412694003190 generic binding surface I; other site 412694003191 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 412694003192 putative active site [active] 412694003193 putative catalytic site [active] 412694003194 putative Mg binding site IVb [ion binding]; other site 412694003195 putative phosphate binding site [ion binding]; other site 412694003196 putative DNA binding site [nucleotide binding]; other site 412694003197 putative Mg binding site IVa [ion binding]; other site 412694003198 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 412694003199 Penicillinase repressor; Region: Pencillinase_R; pfam03965 412694003200 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 412694003201 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 412694003202 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412694003203 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412694003204 Predicted membrane protein [Function unknown]; Region: COG1511 412694003205 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 412694003206 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 412694003207 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 412694003208 DinB superfamily; Region: DinB_2; pfam12867 412694003209 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 412694003210 Predicted transcriptional regulator [Transcription]; Region: COG2378 412694003211 HTH domain; Region: HTH_11; pfam08279 412694003212 WYL domain; Region: WYL; pfam13280 412694003213 Transcriptional regulators [Transcription]; Region: PurR; COG1609 412694003214 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 412694003215 DNA binding site [nucleotide binding] 412694003216 domain linker motif; other site 412694003217 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 412694003218 putative dimerization interface [polypeptide binding]; other site 412694003219 putative ligand binding site [chemical binding]; other site 412694003220 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 412694003221 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 412694003222 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 412694003223 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 412694003224 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 412694003225 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 412694003226 acyl-activating enzyme (AAE) consensus motif; other site 412694003227 putative AMP binding site [chemical binding]; other site 412694003228 putative active site [active] 412694003229 putative CoA binding site [chemical binding]; other site 412694003230 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 412694003231 heme-binding site [chemical binding]; other site 412694003232 S-layer homology domain; Region: SLH; pfam00395 412694003233 S-layer homology domain; Region: SLH; pfam00395 412694003234 S-layer homology domain; Region: SLH; pfam00395 412694003235 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 412694003236 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 412694003237 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 412694003238 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412694003239 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 412694003240 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 412694003241 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 412694003242 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 412694003243 putative active site [active] 412694003244 putative metal binding site [ion binding]; other site 412694003245 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 412694003246 Zn2+ binding site [ion binding]; other site 412694003247 Mg2+ binding site [ion binding]; other site 412694003248 Putative zinc-finger; Region: zf-HC2; pfam13490 412694003249 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 412694003250 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 412694003251 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412694003252 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 412694003253 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412694003254 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 412694003255 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412694003256 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694003257 dimer interface [polypeptide binding]; other site 412694003258 phosphorylation site [posttranslational modification] 412694003259 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694003260 ATP binding site [chemical binding]; other site 412694003261 Mg2+ binding site [ion binding]; other site 412694003262 G-X-G motif; other site 412694003263 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412694003264 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694003265 active site 412694003266 phosphorylation site [posttranslational modification] 412694003267 intermolecular recognition site; other site 412694003268 dimerization interface [polypeptide binding]; other site 412694003269 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412694003270 DNA binding site [nucleotide binding] 412694003271 CAAX protease self-immunity; Region: Abi; pfam02517 412694003272 Peptidase family M48; Region: Peptidase_M48; pfam01435 412694003273 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 412694003274 EamA-like transporter family; Region: EamA; pfam00892 412694003275 EamA-like transporter family; Region: EamA; pfam00892 412694003276 S-layer homology domain; Region: SLH; pfam00395 412694003277 S-layer homology domain; Region: SLH; pfam00395 412694003278 S-layer homology domain; Region: SLH; pfam00395 412694003279 S-layer homology domain; Region: SLH; pfam00395 412694003280 S-layer homology domain; Region: SLH; pfam00395 412694003281 S-layer homology domain; Region: SLH; pfam00395 412694003282 S-layer homology domain; Region: SLH; pfam00395 412694003283 S-layer homology domain; Region: SLH; pfam00395 412694003284 S-layer homology domain; Region: SLH; pfam00395 412694003285 malate synthase A; Region: malate_syn_A; TIGR01344 412694003286 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 412694003287 active site 412694003288 isocitrate lyase; Provisional; Region: PRK15063 412694003289 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 412694003290 tetramer interface [polypeptide binding]; other site 412694003291 active site 412694003292 Mg2+/Mn2+ binding site [ion binding]; other site 412694003293 Phosphotransferase enzyme family; Region: APH; pfam01636 412694003294 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 412694003295 active site 412694003296 substrate binding site [chemical binding]; other site 412694003297 ATP binding site [chemical binding]; other site 412694003298 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 412694003299 DNA-binding site [nucleotide binding]; DNA binding site 412694003300 RNA-binding motif; other site 412694003301 ComK protein; Region: ComK; pfam06338 412694003302 Uncharacterized conserved protein [Function unknown]; Region: COG0398 412694003303 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 412694003304 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 412694003305 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 412694003306 Catalytic site [active] 412694003307 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 412694003308 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 412694003309 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 412694003310 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 412694003311 Part of AAA domain; Region: AAA_19; pfam13245 412694003312 Family description; Region: UvrD_C_2; pfam13538 412694003313 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 412694003314 hypothetical protein; Provisional; Region: PRK07758 412694003315 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 412694003316 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 412694003317 Spore germination protein GerPC; Region: GerPC; pfam10737 412694003318 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 412694003319 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 412694003320 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 412694003321 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 412694003322 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 412694003323 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 412694003324 inhibitor-cofactor binding pocket; inhibition site 412694003325 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694003326 catalytic residue [active] 412694003327 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 412694003328 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 412694003329 active site 412694003330 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 412694003331 dimer interface [polypeptide binding]; other site 412694003332 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 412694003333 Ligand Binding Site [chemical binding]; other site 412694003334 Molecular Tunnel; other site 412694003335 ferrochelatase; Provisional; Region: PRK12435 412694003336 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 412694003337 C-terminal domain interface [polypeptide binding]; other site 412694003338 active site 412694003339 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 412694003340 active site 412694003341 N-terminal domain interface [polypeptide binding]; other site 412694003342 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 412694003343 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 412694003344 tetramer interface [polypeptide binding]; other site 412694003345 heme binding pocket [chemical binding]; other site 412694003346 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 412694003347 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 412694003348 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 412694003349 active site 412694003350 catalytic site [active] 412694003351 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412694003352 non-specific DNA binding site [nucleotide binding]; other site 412694003353 salt bridge; other site 412694003354 sequence-specific DNA binding site [nucleotide binding]; other site 412694003355 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 412694003356 binding surface 412694003357 TPR motif; other site 412694003358 Tetratricopeptide repeat; Region: TPR_12; pfam13424 412694003359 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 412694003360 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 412694003361 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 412694003362 S1 domain; Region: S1_2; pfam13509 412694003363 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 412694003364 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 412694003365 Uncharacterized conserved protein [Function unknown]; Region: COG1284 412694003366 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 412694003367 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 412694003368 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 412694003369 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 412694003370 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412694003371 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 412694003372 active site 412694003373 motif I; other site 412694003374 motif II; other site 412694003375 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 412694003376 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 412694003377 Clp amino terminal domain; Region: Clp_N; pfam02861 412694003378 Clp amino terminal domain; Region: Clp_N; pfam02861 412694003379 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412694003380 Walker A motif; other site 412694003381 ATP binding site [chemical binding]; other site 412694003382 Walker B motif; other site 412694003383 arginine finger; other site 412694003384 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412694003385 Walker A motif; other site 412694003386 ATP binding site [chemical binding]; other site 412694003387 Walker B motif; other site 412694003388 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 412694003389 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 412694003390 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 412694003391 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 412694003392 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412694003393 NAD(P) binding site [chemical binding]; other site 412694003394 active site 412694003395 ComZ; Region: ComZ; pfam10815 412694003396 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 412694003397 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 412694003398 dimer interface [polypeptide binding]; other site 412694003399 active site 412694003400 CoA binding pocket [chemical binding]; other site 412694003401 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 412694003402 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 412694003403 dimer interface [polypeptide binding]; other site 412694003404 active site 412694003405 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 412694003406 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 412694003407 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 412694003408 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 412694003409 active site 412694003410 HIGH motif; other site 412694003411 dimer interface [polypeptide binding]; other site 412694003412 KMSKS motif; other site 412694003413 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 412694003414 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 412694003415 peptide binding site [polypeptide binding]; other site 412694003416 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 412694003417 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694003418 dimer interface [polypeptide binding]; other site 412694003419 conserved gate region; other site 412694003420 putative PBP binding loops; other site 412694003421 ABC-ATPase subunit interface; other site 412694003422 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 412694003423 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 412694003424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694003425 dimer interface [polypeptide binding]; other site 412694003426 conserved gate region; other site 412694003427 putative PBP binding loops; other site 412694003428 ABC-ATPase subunit interface; other site 412694003429 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 412694003430 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 412694003431 Walker A/P-loop; other site 412694003432 ATP binding site [chemical binding]; other site 412694003433 Q-loop/lid; other site 412694003434 ABC transporter signature motif; other site 412694003435 Walker B; other site 412694003436 D-loop; other site 412694003437 H-loop/switch region; other site 412694003438 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 412694003439 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 412694003440 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 412694003441 Walker A/P-loop; other site 412694003442 ATP binding site [chemical binding]; other site 412694003443 Q-loop/lid; other site 412694003444 ABC transporter signature motif; other site 412694003445 Walker B; other site 412694003446 D-loop; other site 412694003447 H-loop/switch region; other site 412694003448 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 412694003449 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 412694003450 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 412694003451 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 412694003452 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 412694003453 peptide binding site [polypeptide binding]; other site 412694003454 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 412694003455 ArsC family; Region: ArsC; pfam03960 412694003456 putative catalytic residues [active] 412694003457 thiol/disulfide switch; other site 412694003458 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 412694003459 adaptor protein; Provisional; Region: PRK02315 412694003460 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 412694003461 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 412694003462 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 412694003463 putative active site [active] 412694003464 catalytic site [active] 412694003465 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 412694003466 putative active site [active] 412694003467 catalytic site [active] 412694003468 Competence protein CoiA-like family; Region: CoiA; cl11541 412694003469 oligoendopeptidase F; Region: pepF; TIGR00181 412694003470 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 412694003471 active site 412694003472 Zn binding site [ion binding]; other site 412694003473 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 412694003474 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 412694003475 catalytic residues [active] 412694003476 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 412694003477 apolar tunnel; other site 412694003478 heme binding site [chemical binding]; other site 412694003479 dimerization interface [polypeptide binding]; other site 412694003480 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 412694003481 putative active site [active] 412694003482 putative metal binding residues [ion binding]; other site 412694003483 signature motif; other site 412694003484 putative triphosphate binding site [ion binding]; other site 412694003485 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 412694003486 synthetase active site [active] 412694003487 NTP binding site [chemical binding]; other site 412694003488 metal binding site [ion binding]; metal-binding site 412694003489 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 412694003490 ATP-NAD kinase; Region: NAD_kinase; pfam01513 412694003491 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 412694003492 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 412694003493 active site 412694003494 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 412694003495 trimer interface [polypeptide binding]; other site 412694003496 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 412694003497 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 412694003498 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 412694003499 active site 412694003500 metal binding site [ion binding]; metal-binding site 412694003501 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 412694003502 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 412694003503 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 412694003504 active site 412694003505 Methyltransferase domain; Region: Methyltransf_23; pfam13489 412694003506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694003507 S-adenosylmethionine binding site [chemical binding]; other site 412694003508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 412694003509 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 412694003510 putative metal binding site; other site 412694003511 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412694003512 binding surface 412694003513 TPR motif; other site 412694003514 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 412694003515 binding surface 412694003516 TPR motif; other site 412694003517 Methyltransferase domain; Region: Methyltransf_23; pfam13489 412694003518 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694003519 S-adenosylmethionine binding site [chemical binding]; other site 412694003520 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 412694003521 catalytic residues [active] 412694003522 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 412694003523 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 412694003524 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 412694003525 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 412694003526 active site 412694003527 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 412694003528 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 412694003529 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 412694003530 NAD binding site [chemical binding]; other site 412694003531 substrate binding site [chemical binding]; other site 412694003532 homodimer interface [polypeptide binding]; other site 412694003533 active site 412694003534 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 412694003535 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 412694003536 NADP binding site [chemical binding]; other site 412694003537 active site 412694003538 putative substrate binding site [chemical binding]; other site 412694003539 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 412694003540 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 412694003541 NAD binding site [chemical binding]; other site 412694003542 homotetramer interface [polypeptide binding]; other site 412694003543 homodimer interface [polypeptide binding]; other site 412694003544 substrate binding site [chemical binding]; other site 412694003545 active site 412694003546 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 412694003547 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 412694003548 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 412694003549 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 412694003550 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 412694003551 Part of AAA domain; Region: AAA_19; pfam13245 412694003552 Family description; Region: UvrD_C_2; pfam13538 412694003553 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 412694003554 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694003555 Coenzyme A binding pocket [chemical binding]; other site 412694003556 hypothetical protein; Provisional; Region: PRK13679 412694003557 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 412694003558 Putative esterase; Region: Esterase; pfam00756 412694003559 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 412694003560 EamA-like transporter family; Region: EamA; pfam00892 412694003561 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 412694003562 EamA-like transporter family; Region: EamA; pfam00892 412694003563 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 412694003564 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 412694003565 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 412694003566 Na binding site [ion binding]; other site 412694003567 anthranilate synthase component I; Provisional; Region: PRK13570 412694003568 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 412694003569 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 412694003570 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 412694003571 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 412694003572 glutamine binding [chemical binding]; other site 412694003573 catalytic triad [active] 412694003574 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 412694003575 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 412694003576 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 412694003577 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 412694003578 active site 412694003579 ribulose/triose binding site [chemical binding]; other site 412694003580 phosphate binding site [ion binding]; other site 412694003581 substrate (anthranilate) binding pocket [chemical binding]; other site 412694003582 product (indole) binding pocket [chemical binding]; other site 412694003583 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 412694003584 active site 412694003585 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 412694003586 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 412694003587 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694003588 catalytic residue [active] 412694003589 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 412694003590 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 412694003591 substrate binding site [chemical binding]; other site 412694003592 active site 412694003593 catalytic residues [active] 412694003594 heterodimer interface [polypeptide binding]; other site 412694003595 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 412694003596 L-lactate permease; Region: Lactate_perm; cl00701 412694003597 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 412694003598 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 412694003599 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 412694003600 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 412694003601 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 412694003602 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 412694003603 Protein of unknown function (DUF3908); Region: DUF3908; pfam13048 412694003604 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 412694003605 NADPH bind site [chemical binding]; other site 412694003606 putative FMN binding site [chemical binding]; other site 412694003607 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 412694003608 putative FMN binding site [chemical binding]; other site 412694003609 NADPH bind site [chemical binding]; other site 412694003610 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 412694003611 YcaO-like family; Region: YcaO; pfam02624 412694003612 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 412694003613 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 412694003614 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 412694003615 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 412694003616 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 412694003617 E3 interaction surface; other site 412694003618 lipoyl attachment site [posttranslational modification]; other site 412694003619 e3 binding domain; Region: E3_binding; pfam02817 412694003620 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 412694003621 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 412694003622 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 412694003623 TPP-binding site [chemical binding]; other site 412694003624 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 412694003625 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412694003626 salt bridge; other site 412694003627 non-specific DNA binding site [nucleotide binding]; other site 412694003628 sequence-specific DNA binding site [nucleotide binding]; other site 412694003629 Predicted transcriptional regulators [Transcription]; Region: COG1695 412694003630 Transcriptional regulator PadR-like family; Region: PadR; cl17335 412694003631 Methyltransferase domain; Region: Methyltransf_23; pfam13489 412694003632 Methyltransferase domain; Region: Methyltransf_25; pfam13649 412694003633 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 412694003634 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 412694003635 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412694003636 catalytic residue [active] 412694003637 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 412694003638 classical (c) SDRs; Region: SDR_c; cd05233 412694003639 NAD(P) binding site [chemical binding]; other site 412694003640 active site 412694003641 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 412694003642 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412694003643 Walker A/P-loop; other site 412694003644 ATP binding site [chemical binding]; other site 412694003645 Q-loop/lid; other site 412694003646 ABC transporter signature motif; other site 412694003647 Walker B; other site 412694003648 D-loop; other site 412694003649 H-loop/switch region; other site 412694003650 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 412694003651 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 412694003652 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 412694003653 GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440 412694003654 GIY-YIG motif/motif A; other site 412694003655 putative active site [active] 412694003656 putative metal binding site [ion binding]; other site 412694003657 Protein of unknown function DUF91; Region: DUF91; cl00709 412694003658 Protein of unknown function (DUF1411); Region: DUF1411; pfam07199 412694003659 multiple promoter invertase; Provisional; Region: mpi; PRK13413 412694003660 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 412694003661 catalytic residues [active] 412694003662 catalytic nucleophile [active] 412694003663 Presynaptic Site I dimer interface [polypeptide binding]; other site 412694003664 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 412694003665 Synaptic Flat tetramer interface [polypeptide binding]; other site 412694003666 Synaptic Site I dimer interface [polypeptide binding]; other site 412694003667 DNA binding site [nucleotide binding] 412694003668 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412694003669 GIY-YIG domain of uncharacterized hypothetical protein found in phycodnavirus PBCV-1 DNA virus, T. thermophila Tlr element eoncoding protein Tlr8p, and similar proteins found in bacteria; Region: GIY-YIG_HE_Tlr8p_PBC-V_like; cd10443 412694003670 GIY-YIG motif/motif A; other site 412694003671 putative active site [active] 412694003672 putative metal binding site [ion binding]; other site 412694003673 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 412694003674 DNA-binding interface [nucleotide binding]; DNA binding site 412694003675 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 412694003676 DNA-binding interface [nucleotide binding]; DNA binding site 412694003677 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 412694003678 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 412694003679 active site 412694003680 Int/Topo IB signature motif; other site 412694003681 DNA binding site [nucleotide binding] 412694003682 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694003683 S-adenosylmethionine binding site [chemical binding]; other site 412694003684 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 412694003685 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 412694003686 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 412694003687 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 412694003688 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 412694003689 Catalytic site [active] 412694003690 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 412694003691 Domain of unknown function (DUF4047); Region: DUF4047; pfam13256 412694003692 Camelysin metallo-endopeptidase; Region: Peptidase_M73; pfam12389 412694003693 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 412694003694 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412694003695 non-specific DNA binding site [nucleotide binding]; other site 412694003696 salt bridge; other site 412694003697 sequence-specific DNA binding site [nucleotide binding]; other site 412694003698 Anti-repressor SinI; Region: SinI; pfam08671 412694003699 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 412694003700 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 412694003701 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 412694003702 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 412694003703 NAD(P) binding site [chemical binding]; other site 412694003704 catalytic residues [active] 412694003705 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 412694003706 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 412694003707 Walker A/P-loop; other site 412694003708 ATP binding site [chemical binding]; other site 412694003709 Q-loop/lid; other site 412694003710 ABC transporter signature motif; other site 412694003711 Walker B; other site 412694003712 D-loop; other site 412694003713 H-loop/switch region; other site 412694003714 TOBE domain; Region: TOBE_2; pfam08402 412694003715 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 412694003716 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694003717 dimer interface [polypeptide binding]; other site 412694003718 conserved gate region; other site 412694003719 putative PBP binding loops; other site 412694003720 ABC-ATPase subunit interface; other site 412694003721 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 412694003722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694003723 dimer interface [polypeptide binding]; other site 412694003724 conserved gate region; other site 412694003725 putative PBP binding loops; other site 412694003726 ABC-ATPase subunit interface; other site 412694003727 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 412694003728 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 412694003729 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 412694003730 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 412694003731 active site 412694003732 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 412694003733 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 412694003734 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 412694003735 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 412694003736 active site 412694003737 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 412694003738 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 412694003739 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 412694003740 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 412694003741 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 412694003742 Cysteine-rich domain; Region: CCG; pfam02754 412694003743 Cysteine-rich domain; Region: CCG; pfam02754 412694003744 FAD binding domain; Region: FAD_binding_4; pfam01565 412694003745 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 412694003746 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 412694003747 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 412694003748 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 412694003749 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 412694003750 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 412694003751 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412694003752 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694003753 active site 412694003754 phosphorylation site [posttranslational modification] 412694003755 intermolecular recognition site; other site 412694003756 dimerization interface [polypeptide binding]; other site 412694003757 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412694003758 DNA binding site [nucleotide binding] 412694003759 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 412694003760 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412694003761 dimerization interface [polypeptide binding]; other site 412694003762 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694003763 dimer interface [polypeptide binding]; other site 412694003764 phosphorylation site [posttranslational modification] 412694003765 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694003766 ATP binding site [chemical binding]; other site 412694003767 Mg2+ binding site [ion binding]; other site 412694003768 G-X-G motif; other site 412694003769 Transcriptional regulators [Transcription]; Region: FadR; COG2186 412694003770 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412694003771 DNA-binding site [nucleotide binding]; DNA binding site 412694003772 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 412694003773 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 412694003774 Cysteine-rich domain; Region: CCG; pfam02754 412694003775 Cysteine-rich domain; Region: CCG; pfam02754 412694003776 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 412694003777 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 412694003778 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 412694003779 Uncharacterized conserved protein [Function unknown]; Region: COG1556 412694003780 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 412694003781 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 412694003782 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 412694003783 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 412694003784 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 412694003785 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 412694003786 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 412694003787 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 412694003788 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 412694003789 dimer interaction site [polypeptide binding]; other site 412694003790 substrate-binding tunnel; other site 412694003791 active site 412694003792 catalytic site [active] 412694003793 substrate binding site [chemical binding]; other site 412694003794 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820 412694003795 poly-beta-hydroxybutyrate-responsive repressor; Region: repress_PhaQ; TIGR02719 412694003796 Predicted transcriptional regulators [Transcription]; Region: COG1695 412694003797 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 412694003798 acetoacetyl-CoA reductase; Provisional; Region: PRK12935 412694003799 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 412694003800 NAD(P) binding site [chemical binding]; other site 412694003801 homotetramer interface [polypeptide binding]; other site 412694003802 homodimer interface [polypeptide binding]; other site 412694003803 active site 412694003804 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 412694003805 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 412694003806 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 412694003807 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 412694003808 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 412694003809 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 412694003810 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 412694003811 Protein of unknown function (DUF3905); Region: DUF3905; pfam13045 412694003812 putative 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate-binding protein; Region: phnS2; TIGR03261 412694003813 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 412694003814 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 412694003815 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412694003816 Walker A/P-loop; other site 412694003817 ATP binding site [chemical binding]; other site 412694003818 Q-loop/lid; other site 412694003819 ABC transporter signature motif; other site 412694003820 Walker B; other site 412694003821 D-loop; other site 412694003822 H-loop/switch region; other site 412694003823 TOBE domain; Region: TOBE_2; pfam08402 412694003824 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 412694003825 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694003826 dimer interface [polypeptide binding]; other site 412694003827 conserved gate region; other site 412694003828 putative PBP binding loops; other site 412694003829 ABC-ATPase subunit interface; other site 412694003830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694003831 dimer interface [polypeptide binding]; other site 412694003832 conserved gate region; other site 412694003833 putative PBP binding loops; other site 412694003834 ABC-ATPase subunit interface; other site 412694003835 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 412694003836 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412694003837 motif II; other site 412694003838 2-aminoethylphosphonate--pyruvate transaminase; Region: transamin_PhnW; TIGR02326 412694003839 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412694003840 catalytic residue [active] 412694003841 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 412694003842 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 412694003843 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 412694003844 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 412694003845 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 412694003846 heme-binding site [chemical binding]; other site 412694003847 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 412694003848 Leucine rich repeat; Region: LRR_8; pfam13855 412694003849 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 412694003850 Leucine rich repeat; Region: LRR_8; pfam13855 412694003851 Leucine-rich repeats; other site 412694003852 Substrate binding site [chemical binding]; other site 412694003853 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 412694003854 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 412694003855 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 412694003856 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 412694003857 S-layer homology domain; Region: SLH; pfam00395 412694003858 S-layer homology domain; Region: SLH; pfam00395 412694003859 S-layer homology domain; Region: SLH; pfam00395 412694003860 hypothetical protein; Validated; Region: PRK06755 412694003861 intersubunit interface [polypeptide binding]; other site 412694003862 active site 412694003863 Zn2+ binding site [ion binding]; other site 412694003864 FOG: CBS domain [General function prediction only]; Region: COG0517 412694003865 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 412694003866 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 412694003867 NodB motif; other site 412694003868 putative active site [active] 412694003869 putative catalytic site [active] 412694003870 Zn binding site [ion binding]; other site 412694003871 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346 412694003872 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694003873 dimer interface [polypeptide binding]; other site 412694003874 phosphorylation site [posttranslational modification] 412694003875 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694003876 ATP binding site [chemical binding]; other site 412694003877 Mg2+ binding site [ion binding]; other site 412694003878 G-X-G motif; other site 412694003879 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 412694003880 MarR family; Region: MarR; pfam01047 412694003881 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 412694003882 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 412694003883 active site 412694003884 Zn binding site [ion binding]; other site 412694003885 DinB superfamily; Region: DinB_2; pfam12867 412694003886 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 412694003887 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694003888 dimer interface [polypeptide binding]; other site 412694003889 phosphorylation site [posttranslational modification] 412694003890 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694003891 ATP binding site [chemical binding]; other site 412694003892 Mg2+ binding site [ion binding]; other site 412694003893 G-X-G motif; other site 412694003894 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 412694003895 Ligand Binding Site [chemical binding]; other site 412694003896 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 412694003897 active site 412694003898 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 412694003899 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 412694003900 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 412694003901 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; pfam09953 412694003902 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 412694003903 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 412694003904 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694003905 Coenzyme A binding pocket [chemical binding]; other site 412694003906 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 412694003907 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 412694003908 Class I ribonucleotide reductase; Region: RNR_I; cd01679 412694003909 active site 412694003910 dimer interface [polypeptide binding]; other site 412694003911 catalytic residues [active] 412694003912 effector binding site; other site 412694003913 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 412694003914 active site 412694003915 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 412694003916 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 412694003917 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 412694003918 dimer interface [polypeptide binding]; other site 412694003919 putative radical transfer pathway; other site 412694003920 diiron center [ion binding]; other site 412694003921 tyrosyl radical; other site 412694003922 Predicted transcriptional regulators [Transcription]; Region: COG1725 412694003923 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412694003924 DNA-binding site [nucleotide binding]; DNA binding site 412694003925 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 412694003926 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 412694003927 Walker A/P-loop; other site 412694003928 ATP binding site [chemical binding]; other site 412694003929 Q-loop/lid; other site 412694003930 ABC transporter signature motif; other site 412694003931 Walker B; other site 412694003932 D-loop; other site 412694003933 H-loop/switch region; other site 412694003934 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 412694003935 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412694003936 Walker A/P-loop; other site 412694003937 ATP binding site [chemical binding]; other site 412694003938 Q-loop/lid; other site 412694003939 ABC transporter signature motif; other site 412694003940 Walker B; other site 412694003941 D-loop; other site 412694003942 H-loop/switch region; other site 412694003943 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 412694003944 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 412694003945 CAAX protease self-immunity; Region: Abi; pfam02517 412694003946 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 412694003947 Protein of unknown function (DUF3913); Region: DUF3913; pfam13052 412694003948 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 412694003949 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412694003950 putative DNA binding site [nucleotide binding]; other site 412694003951 putative Zn2+ binding site [ion binding]; other site 412694003952 AsnC family; Region: AsnC_trans_reg; pfam01037 412694003953 Uncharacterized conserved protein [Function unknown]; Region: COG2128 412694003954 Isochorismatase family; Region: Isochorismatase; pfam00857 412694003955 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 412694003956 catalytic triad [active] 412694003957 conserved cis-peptide bond; other site 412694003958 SseB protein; Region: SseB; cl06279 412694003959 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 412694003960 dimer interface [polypeptide binding]; other site 412694003961 catalytic triad [active] 412694003962 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 412694003963 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 412694003964 FMN binding site [chemical binding]; other site 412694003965 substrate binding site [chemical binding]; other site 412694003966 putative catalytic residue [active] 412694003967 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 412694003968 DltD N-terminal region; Region: DltD_N; pfam04915 412694003969 DltD central region; Region: DltD_M; pfam04918 412694003970 DltD C-terminal region; Region: DltD_C; pfam04914 412694003971 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 412694003972 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 412694003973 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 412694003974 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 412694003975 acyl-activating enzyme (AAE) consensus motif; other site 412694003976 AMP binding site [chemical binding]; other site 412694003977 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 412694003978 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 412694003979 metal binding site [ion binding]; metal-binding site 412694003980 dimer interface [polypeptide binding]; other site 412694003981 flavodoxin; Provisional; Region: PRK06756 412694003982 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 412694003983 Phosphotransferase enzyme family; Region: APH; pfam01636 412694003984 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 412694003985 active site 412694003986 substrate binding site [chemical binding]; other site 412694003987 ATP binding site [chemical binding]; other site 412694003988 multidrug efflux protein; Reviewed; Region: PRK01766 412694003989 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 412694003990 cation binding site [ion binding]; other site 412694003991 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 412694003992 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 412694003993 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 412694003994 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 412694003995 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 412694003996 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 412694003997 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 412694003998 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 412694003999 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 412694004000 hypothetical protein; Provisional; Region: PRK03094 412694004001 Protein of unknown function (DUF3911); Region: DUF3911; pfam13050 412694004002 flavin-containing monooxygenase FMO GS-OX; Region: PLN02172 412694004003 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 412694004004 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 412694004005 homodimer interface [polypeptide binding]; other site 412694004006 substrate-cofactor binding pocket; other site 412694004007 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694004008 catalytic residue [active] 412694004009 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 412694004010 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 412694004011 PYR/PP interface [polypeptide binding]; other site 412694004012 dimer interface [polypeptide binding]; other site 412694004013 TPP binding site [chemical binding]; other site 412694004014 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 412694004015 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 412694004016 TPP-binding site [chemical binding]; other site 412694004017 dimer interface [polypeptide binding]; other site 412694004018 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 412694004019 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 412694004020 putative valine binding site [chemical binding]; other site 412694004021 dimer interface [polypeptide binding]; other site 412694004022 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 412694004023 ketol-acid reductoisomerase; Provisional; Region: PRK05479 412694004024 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 412694004025 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 412694004026 2-isopropylmalate synthase; Validated; Region: PRK00915 412694004027 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 412694004028 active site 412694004029 catalytic residues [active] 412694004030 metal binding site [ion binding]; metal-binding site 412694004031 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 412694004032 tartrate dehydrogenase; Region: TTC; TIGR02089 412694004033 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 412694004034 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 412694004035 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 412694004036 substrate binding site [chemical binding]; other site 412694004037 ligand binding site [chemical binding]; other site 412694004038 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 412694004039 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 412694004040 substrate binding site [chemical binding]; other site 412694004041 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 412694004042 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 412694004043 dimer interface [polypeptide binding]; other site 412694004044 motif 1; other site 412694004045 active site 412694004046 motif 2; other site 412694004047 motif 3; other site 412694004048 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 412694004049 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 412694004050 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 412694004051 histidinol dehydrogenase; Region: hisD; TIGR00069 412694004052 NAD binding site [chemical binding]; other site 412694004053 dimerization interface [polypeptide binding]; other site 412694004054 product binding site; other site 412694004055 substrate binding site [chemical binding]; other site 412694004056 zinc binding site [ion binding]; other site 412694004057 catalytic residues [active] 412694004058 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 412694004059 putative active site pocket [active] 412694004060 4-fold oligomerization interface [polypeptide binding]; other site 412694004061 metal binding residues [ion binding]; metal-binding site 412694004062 3-fold/trimer interface [polypeptide binding]; other site 412694004063 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 412694004064 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 412694004065 putative active site [active] 412694004066 oxyanion strand; other site 412694004067 catalytic triad [active] 412694004068 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 412694004069 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 412694004070 catalytic residues [active] 412694004071 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 412694004072 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 412694004073 substrate binding site [chemical binding]; other site 412694004074 glutamase interaction surface [polypeptide binding]; other site 412694004075 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 412694004076 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 412694004077 metal binding site [ion binding]; metal-binding site 412694004078 histidinol-phosphatase; Validated; Region: PRK06740 412694004079 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 412694004080 dimer interface [polypeptide binding]; other site 412694004081 active site 412694004082 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 412694004083 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 412694004084 putative ligand binding site [chemical binding]; other site 412694004085 putative NAD binding site [chemical binding]; other site 412694004086 catalytic site [active] 412694004087 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 412694004088 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 412694004089 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 412694004090 Sulfatase; Region: Sulfatase; pfam00884 412694004091 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 412694004092 diaminopimelate decarboxylase; Region: lysA; TIGR01048 412694004093 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 412694004094 active site 412694004095 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 412694004096 substrate binding site [chemical binding]; other site 412694004097 catalytic residues [active] 412694004098 dimer interface [polypeptide binding]; other site 412694004099 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 412694004100 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 412694004101 Active Sites [active] 412694004102 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 412694004103 ATP-sulfurylase; Region: ATPS; cd00517 412694004104 active site 412694004105 HXXH motif; other site 412694004106 flexible loop; other site 412694004107 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 412694004108 ligand-binding site [chemical binding]; other site 412694004109 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 412694004110 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 412694004111 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 412694004112 Protein of unknown function (DUF3906); Region: DUF3906; pfam13046 412694004113 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 412694004114 diphthine synthase; Region: dph5; TIGR00522 412694004115 active site 412694004116 SAM binding site [chemical binding]; other site 412694004117 homodimer interface [polypeptide binding]; other site 412694004118 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 412694004119 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 412694004120 putative active site [active] 412694004121 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 412694004122 putative active site [active] 412694004123 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 412694004124 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 412694004125 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 412694004126 Na2 binding site [ion binding]; other site 412694004127 putative substrate binding site 1 [chemical binding]; other site 412694004128 Na binding site 1 [ion binding]; other site 412694004129 putative substrate binding site 2 [chemical binding]; other site 412694004130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 412694004131 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 412694004132 Peptidase family M23; Region: Peptidase_M23; pfam01551 412694004133 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 412694004134 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 412694004135 Protein of unknown function (DUF402); Region: DUF402; cl00979 412694004136 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 412694004137 Vpu protein; Region: Vpu; pfam00558 412694004138 PspA/IM30 family; Region: PspA_IM30; pfam04012 412694004139 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 412694004140 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 412694004141 Histidine kinase; Region: HisKA_3; pfam07730 412694004142 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694004143 ATP binding site [chemical binding]; other site 412694004144 Mg2+ binding site [ion binding]; other site 412694004145 G-X-G motif; other site 412694004146 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 412694004147 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694004148 active site 412694004149 phosphorylation site [posttranslational modification] 412694004150 intermolecular recognition site; other site 412694004151 dimerization interface [polypeptide binding]; other site 412694004152 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 412694004153 DNA binding residues [nucleotide binding] 412694004154 dimerization interface [polypeptide binding]; other site 412694004155 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 412694004156 E3 interaction surface; other site 412694004157 lipoyl attachment site [posttranslational modification]; other site 412694004158 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 412694004159 Methyltransferase domain; Region: Methyltransf_31; pfam13847 412694004160 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694004161 S-adenosylmethionine binding site [chemical binding]; other site 412694004162 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 412694004163 Peptidase family M50; Region: Peptidase_M50; pfam02163 412694004164 active site 412694004165 putative substrate binding region [chemical binding]; other site 412694004166 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 412694004167 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 412694004168 heme-binding site [chemical binding]; other site 412694004169 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 412694004170 FAD binding pocket [chemical binding]; other site 412694004171 FAD binding motif [chemical binding]; other site 412694004172 phosphate binding motif [ion binding]; other site 412694004173 beta-alpha-beta structure motif; other site 412694004174 NAD binding pocket [chemical binding]; other site 412694004175 Heme binding pocket [chemical binding]; other site 412694004176 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 412694004177 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 412694004178 ligand binding site [chemical binding]; other site 412694004179 flexible hinge region; other site 412694004180 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 412694004181 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 412694004182 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 412694004183 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 412694004184 Transglycosylase; Region: Transgly; pfam00912 412694004185 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 412694004186 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 412694004187 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 412694004188 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 412694004189 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 412694004190 putative active site [active] 412694004191 heme pocket [chemical binding]; other site 412694004192 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694004193 dimer interface [polypeptide binding]; other site 412694004194 phosphorylation site [posttranslational modification] 412694004195 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694004196 ATP binding site [chemical binding]; other site 412694004197 Mg2+ binding site [ion binding]; other site 412694004198 G-X-G motif; other site 412694004199 Protein of unknown function DUF72; Region: DUF72; pfam01904 412694004200 Protein of unknown function (DUF3924); Region: DUF3924; pfam13062 412694004201 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 412694004202 active site 412694004203 DNA binding site [nucleotide binding] 412694004204 Int/Topo IB signature motif; other site 412694004205 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412694004206 dimerization interface [polypeptide binding]; other site 412694004207 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694004208 dimer interface [polypeptide binding]; other site 412694004209 phosphorylation site [posttranslational modification] 412694004210 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694004211 ATP binding site [chemical binding]; other site 412694004212 Mg2+ binding site [ion binding]; other site 412694004213 G-X-G motif; other site 412694004214 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 412694004215 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 412694004216 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 412694004217 Predicted integral membrane protein [Function unknown]; Region: COG0392 412694004218 Uncharacterized conserved protein [Function unknown]; Region: COG2898 412694004219 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 412694004220 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 412694004221 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 412694004222 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 412694004223 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 412694004224 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 412694004225 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 412694004226 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 412694004227 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 412694004228 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 412694004229 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 412694004230 RNA binding surface [nucleotide binding]; other site 412694004231 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 412694004232 active site 412694004233 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 412694004234 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 412694004235 catalytic residues [active] 412694004236 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 412694004237 ResB-like family; Region: ResB; pfam05140 412694004238 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 412694004239 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 412694004240 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412694004241 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694004242 active site 412694004243 phosphorylation site [posttranslational modification] 412694004244 intermolecular recognition site; other site 412694004245 dimerization interface [polypeptide binding]; other site 412694004246 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412694004247 DNA binding site [nucleotide binding] 412694004248 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 412694004249 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412694004250 dimerization interface [polypeptide binding]; other site 412694004251 PAS domain; Region: PAS; smart00091 412694004252 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694004253 dimer interface [polypeptide binding]; other site 412694004254 phosphorylation site [posttranslational modification] 412694004255 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694004256 ATP binding site [chemical binding]; other site 412694004257 Mg2+ binding site [ion binding]; other site 412694004258 G-X-G motif; other site 412694004259 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 412694004260 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 412694004261 Peptidase family M23; Region: Peptidase_M23; pfam01551 412694004262 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 412694004263 Predicted membrane protein [Function unknown]; Region: COG3601 412694004264 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 412694004265 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 412694004266 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 412694004267 DEAD-like helicases superfamily; Region: DEXDc; smart00487 412694004268 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 412694004269 ATP binding site [chemical binding]; other site 412694004270 putative Mg++ binding site [ion binding]; other site 412694004271 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412694004272 nucleotide binding region [chemical binding]; other site 412694004273 ATP-binding site [chemical binding]; other site 412694004274 CAAX protease self-immunity; Region: Abi; pfam02517 412694004275 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 412694004276 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 412694004277 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 412694004278 putative active site [active] 412694004279 putative metal binding site [ion binding]; other site 412694004280 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 412694004281 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 412694004282 DNA binding residues [nucleotide binding] 412694004283 B12 binding domain; Region: B12-binding_2; pfam02607 412694004284 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 412694004285 adaptor protein; Provisional; Region: PRK02899 412694004286 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 412694004287 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 412694004288 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 412694004289 NAD(P) binding site [chemical binding]; other site 412694004290 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 412694004291 amidase catalytic site [active] 412694004292 Zn binding residues [ion binding]; other site 412694004293 substrate binding site [chemical binding]; other site 412694004294 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 412694004295 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 412694004296 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 412694004297 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 412694004298 active site 412694004299 homotetramer interface [polypeptide binding]; other site 412694004300 homodimer interface [polypeptide binding]; other site 412694004301 cytidylate kinase; Provisional; Region: cmk; PRK00023 412694004302 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 412694004303 CMP-binding site; other site 412694004304 The sites determining sugar specificity; other site 412694004305 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 412694004306 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 412694004307 RNA binding site [nucleotide binding]; other site 412694004308 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 412694004309 RNA binding site [nucleotide binding]; other site 412694004310 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 412694004311 RNA binding site [nucleotide binding]; other site 412694004312 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 412694004313 RNA binding site [nucleotide binding]; other site 412694004314 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 412694004315 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 412694004316 homotetramer interface [polypeptide binding]; other site 412694004317 FMN binding site [chemical binding]; other site 412694004318 homodimer contacts [polypeptide binding]; other site 412694004319 putative active site [active] 412694004320 putative substrate binding site [chemical binding]; other site 412694004321 YpzI-like protein; Region: YpzI; pfam14140 412694004322 YIEGIA protein; Region: YIEGIA; pfam14045 412694004323 GTP-binding protein Der; Reviewed; Region: PRK00093 412694004324 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 412694004325 G1 box; other site 412694004326 GTP/Mg2+ binding site [chemical binding]; other site 412694004327 Switch I region; other site 412694004328 G2 box; other site 412694004329 Switch II region; other site 412694004330 G3 box; other site 412694004331 G4 box; other site 412694004332 G5 box; other site 412694004333 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 412694004334 G1 box; other site 412694004335 GTP/Mg2+ binding site [chemical binding]; other site 412694004336 Switch I region; other site 412694004337 G2 box; other site 412694004338 G3 box; other site 412694004339 Switch II region; other site 412694004340 G4 box; other site 412694004341 G5 box; other site 412694004342 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 412694004343 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 412694004344 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 412694004345 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 412694004346 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 412694004347 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 412694004348 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 412694004349 IHF dimer interface [polypeptide binding]; other site 412694004350 IHF - DNA interface [nucleotide binding]; other site 412694004351 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 412694004352 homodecamer interface [polypeptide binding]; other site 412694004353 GTP cyclohydrolase I; Provisional; Region: PLN03044 412694004354 active site 412694004355 putative catalytic site residues [active] 412694004356 zinc binding site [ion binding]; other site 412694004357 GTP-CH-I/GFRP interaction surface; other site 412694004358 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 412694004359 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 412694004360 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694004361 S-adenosylmethionine binding site [chemical binding]; other site 412694004362 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 412694004363 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 412694004364 substrate binding pocket [chemical binding]; other site 412694004365 chain length determination region; other site 412694004366 substrate-Mg2+ binding site; other site 412694004367 catalytic residues [active] 412694004368 aspartate-rich region 1; other site 412694004369 active site lid residues [active] 412694004370 aspartate-rich region 2; other site 412694004371 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 412694004372 active site 412694004373 multimer interface [polypeptide binding]; other site 412694004374 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 412694004375 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 412694004376 Tetramer interface [polypeptide binding]; other site 412694004377 active site 412694004378 FMN-binding site [chemical binding]; other site 412694004379 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 412694004380 active site 412694004381 dimer interface [polypeptide binding]; other site 412694004382 metal binding site [ion binding]; metal-binding site 412694004383 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 412694004384 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412694004385 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694004386 homodimer interface [polypeptide binding]; other site 412694004387 catalytic residue [active] 412694004388 Tetratricopeptide repeat; Region: TPR_12; pfam13424 412694004389 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412694004390 binding surface 412694004391 TPR motif; other site 412694004392 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 412694004393 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412694004394 binding surface 412694004395 TPR motif; other site 412694004396 Tetratricopeptide repeat; Region: TPR_12; pfam13424 412694004397 TPR repeat; Region: TPR_11; pfam13414 412694004398 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412694004399 binding surface 412694004400 TPR motif; other site 412694004401 hypothetical protein; Provisional; Region: PRK03636 412694004402 UPF0302 domain; Region: UPF0302; pfam08864 412694004403 IDEAL domain; Region: IDEAL; pfam08858 412694004404 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 412694004405 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 412694004406 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 412694004407 iron-sulfur cluster [ion binding]; other site 412694004408 [2Fe-2S] cluster binding site [ion binding]; other site 412694004409 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 412694004410 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 412694004411 interchain domain interface [polypeptide binding]; other site 412694004412 intrachain domain interface; other site 412694004413 heme bH binding site [chemical binding]; other site 412694004414 Qi binding site; other site 412694004415 heme bL binding site [chemical binding]; other site 412694004416 Qo binding site; other site 412694004417 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 412694004418 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 412694004419 interchain domain interface [polypeptide binding]; other site 412694004420 intrachain domain interface; other site 412694004421 Qi binding site; other site 412694004422 Qo binding site; other site 412694004423 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 412694004424 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 412694004425 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 412694004426 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 412694004427 sporulation protein YpjB; Region: spore_ypjB; TIGR02878 412694004428 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 412694004429 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 412694004430 active site 412694004431 Fe-S cluster binding site [ion binding]; other site 412694004432 Uncharacterized conserved protein [Function unknown]; Region: COG1284 412694004433 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 412694004434 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 412694004435 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 412694004436 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 412694004437 homodimer interface [polypeptide binding]; other site 412694004438 metal binding site [ion binding]; metal-binding site 412694004439 dihydrodipicolinate reductase; Provisional; Region: PRK00048 412694004440 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 412694004441 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 412694004442 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 412694004443 active site 412694004444 dimer interfaces [polypeptide binding]; other site 412694004445 catalytic residues [active] 412694004446 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 412694004447 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 412694004448 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 412694004449 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 412694004450 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 412694004451 active site 412694004452 NTP binding site [chemical binding]; other site 412694004453 metal binding triad [ion binding]; metal-binding site 412694004454 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 412694004455 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 412694004456 Biotin operon repressor [Transcription]; Region: BirA; COG1654 412694004457 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 412694004458 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 412694004459 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 412694004460 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 412694004461 oligomerization interface [polypeptide binding]; other site 412694004462 active site 412694004463 metal binding site [ion binding]; metal-binding site 412694004464 pantoate--beta-alanine ligase; Region: panC; TIGR00018 412694004465 Pantoate-beta-alanine ligase; Region: PanC; cd00560 412694004466 active site 412694004467 ATP-binding site [chemical binding]; other site 412694004468 pantoate-binding site; other site 412694004469 HXXH motif; other site 412694004470 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 412694004471 tetramerization interface [polypeptide binding]; other site 412694004472 active site 412694004473 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 412694004474 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 412694004475 active site 412694004476 catalytic site [active] 412694004477 substrate binding site [chemical binding]; other site 412694004478 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 412694004479 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412694004480 nucleotide binding region [chemical binding]; other site 412694004481 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 412694004482 aspartate aminotransferase; Provisional; Region: PRK05764 412694004483 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412694004484 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694004485 homodimer interface [polypeptide binding]; other site 412694004486 catalytic residue [active] 412694004487 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 412694004488 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 412694004489 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 412694004490 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 412694004491 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 412694004492 minor groove reading motif; other site 412694004493 helix-hairpin-helix signature motif; other site 412694004494 substrate binding pocket [chemical binding]; other site 412694004495 active site 412694004496 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 412694004497 Transglycosylase; Region: Transgly; pfam00912 412694004498 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 412694004499 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 412694004500 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 412694004501 Interdomain contacts; other site 412694004502 Cytokine receptor motif; other site 412694004503 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 412694004504 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 412694004505 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 412694004506 YppF-like protein; Region: YppF; pfam14178 412694004507 YppG-like protein; Region: YppG; pfam14179 412694004508 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 412694004509 hypothetical protein; Provisional; Region: PRK13660 412694004510 cell division protein GpsB; Provisional; Region: PRK14127 412694004511 DivIVA domain; Region: DivI1A_domain; TIGR03544 412694004512 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 412694004513 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 412694004514 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 412694004515 Protein of unknown function (DUF3921); Region: DUF3921; pfam13060 412694004516 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 412694004517 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 412694004518 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 412694004519 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 412694004520 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 412694004521 active site 412694004522 Zn binding site [ion binding]; other site 412694004523 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 412694004524 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 412694004525 Phosphotransferase enzyme family; Region: APH; pfam01636 412694004526 putative active site [active] 412694004527 putative substrate binding site [chemical binding]; other site 412694004528 ATP binding site [chemical binding]; other site 412694004529 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 412694004530 active site 412694004531 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 412694004532 active site 412694004533 xanthine permease; Region: pbuX; TIGR03173 412694004534 Predicted membrane protein [Function unknown]; Region: COG2311 412694004535 Protein of unknown function (DUF418); Region: DUF418; cl12135 412694004536 Protein of unknown function (DUF418); Region: DUF418; pfam04235 412694004537 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 412694004538 Dynamin family; Region: Dynamin_N; pfam00350 412694004539 G1 box; other site 412694004540 GTP/Mg2+ binding site [chemical binding]; other site 412694004541 G2 box; other site 412694004542 Switch I region; other site 412694004543 G3 box; other site 412694004544 Switch II region; other site 412694004545 G4 box; other site 412694004546 G5 box; other site 412694004547 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 412694004548 Dynamin family; Region: Dynamin_N; pfam00350 412694004549 G1 box; other site 412694004550 GTP/Mg2+ binding site [chemical binding]; other site 412694004551 G2 box; other site 412694004552 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 412694004553 G3 box; other site 412694004554 Switch II region; other site 412694004555 GTP/Mg2+ binding site [chemical binding]; other site 412694004556 G4 box; other site 412694004557 G5 box; other site 412694004558 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694004559 Coenzyme A binding pocket [chemical binding]; other site 412694004560 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 412694004561 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 412694004562 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 412694004563 active site residue [active] 412694004564 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 412694004565 active site residue [active] 412694004566 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 412694004567 Predicted membrane protein [Function unknown]; Region: COG3766 412694004568 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 412694004569 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 412694004570 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 412694004571 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 412694004572 5'-3' exonuclease; Region: 53EXOc; smart00475 412694004573 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 412694004574 active site 412694004575 metal binding site 1 [ion binding]; metal-binding site 412694004576 putative 5' ssDNA interaction site; other site 412694004577 metal binding site 3; metal-binding site 412694004578 metal binding site 2 [ion binding]; metal-binding site 412694004579 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 412694004580 putative DNA binding site [nucleotide binding]; other site 412694004581 putative metal binding site [ion binding]; other site 412694004582 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694004583 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694004584 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694004585 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694004586 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694004587 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694004588 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694004589 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694004590 Domain of unknown function DUF11; Region: DUF11; cl17728 412694004591 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694004592 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694004593 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694004594 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694004595 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694004596 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694004597 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694004598 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694004599 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694004600 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694004601 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694004602 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694004603 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694004604 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694004605 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694004606 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694004607 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694004608 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694004609 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 412694004610 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694004611 Coenzyme A binding pocket [chemical binding]; other site 412694004612 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 412694004613 Isochorismatase family; Region: Isochorismatase; pfam00857 412694004614 catalytic triad [active] 412694004615 conserved cis-peptide bond; other site 412694004616 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 412694004617 EamA-like transporter family; Region: EamA; pfam00892 412694004618 EamA-like transporter family; Region: EamA; cl17759 412694004619 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 412694004620 RNA/DNA hybrid binding site [nucleotide binding]; other site 412694004621 active site 412694004622 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 412694004623 active site 412694004624 catalytic residues [active] 412694004625 QueT transporter; Region: QueT; pfam06177 412694004626 hypothetical protein; Validated; Region: PRK07708 412694004627 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 412694004628 RNA/DNA hybrid binding site [nucleotide binding]; other site 412694004629 active site 412694004630 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 412694004631 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 412694004632 DNA-binding site [nucleotide binding]; DNA binding site 412694004633 RNA-binding motif; other site 412694004634 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 412694004635 LysE type translocator; Region: LysE; pfam01810 412694004636 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 412694004637 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 412694004638 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 412694004639 Na binding site [ion binding]; other site 412694004640 aminotransferase; Validated; Region: PRK07678 412694004641 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 412694004642 inhibitor-cofactor binding pocket; inhibition site 412694004643 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694004644 catalytic residue [active] 412694004645 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 412694004646 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 412694004647 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 412694004648 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 412694004649 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 412694004650 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 412694004651 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 412694004652 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 412694004653 DNA binding residues [nucleotide binding] 412694004654 drug binding residues [chemical binding]; other site 412694004655 dimer interface [polypeptide binding]; other site 412694004656 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 412694004657 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 412694004658 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 412694004659 Predicted membrane protein [Function unknown]; Region: COG2323 412694004660 Uncharacterized conserved protein [Function unknown]; Region: COG1434 412694004661 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 412694004662 putative active site [active] 412694004663 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 412694004664 dimer interface [polypeptide binding]; other site 412694004665 FMN binding site [chemical binding]; other site 412694004666 NADPH bind site [chemical binding]; other site 412694004667 DJ-1 family protein; Region: not_thiJ; TIGR01383 412694004668 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 412694004669 conserved cys residue [active] 412694004670 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 412694004671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694004672 H+ Antiporter protein; Region: 2A0121; TIGR00900 412694004673 putative substrate translocation pore; other site 412694004674 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412694004675 dimerization interface [polypeptide binding]; other site 412694004676 putative DNA binding site [nucleotide binding]; other site 412694004677 putative Zn2+ binding site [ion binding]; other site 412694004678 H+ Antiporter protein; Region: 2A0121; TIGR00900 412694004679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694004680 putative substrate translocation pore; other site 412694004681 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 412694004682 active site 412694004683 metal binding site [ion binding]; metal-binding site 412694004684 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 412694004685 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 412694004686 bacterial Hfq-like; Region: Hfq; cd01716 412694004687 hexamer interface [polypeptide binding]; other site 412694004688 Sm1 motif; other site 412694004689 RNA binding site [nucleotide binding]; other site 412694004690 Sm2 motif; other site 412694004691 HD domain; Region: HD_3; pfam13023 412694004692 flagellar motor protein MotP; Reviewed; Region: PRK06743 412694004693 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 412694004694 flagellar motor protein MotS; Reviewed; Region: PRK06742 412694004695 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 412694004696 ligand binding site [chemical binding]; other site 412694004697 Response regulator receiver domain; Region: Response_reg; pfam00072 412694004698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694004699 active site 412694004700 phosphorylation site [posttranslational modification] 412694004701 intermolecular recognition site; other site 412694004702 dimerization interface [polypeptide binding]; other site 412694004703 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 412694004704 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 412694004705 putative binding surface; other site 412694004706 active site 412694004707 P2 response regulator binding domain; Region: P2; pfam07194 412694004708 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 412694004709 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694004710 ATP binding site [chemical binding]; other site 412694004711 Mg2+ binding site [ion binding]; other site 412694004712 G-X-G motif; other site 412694004713 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 412694004714 flagellar motor switch protein; Reviewed; Region: PRK06782 412694004715 CheC-like family; Region: CheC; pfam04509 412694004716 CheC-like family; Region: CheC; pfam04509 412694004717 CheC-like family; Region: CheC; pfam04509 412694004718 CheC-like family; Region: CheC; pfam04509 412694004719 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 412694004720 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 412694004721 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 412694004722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694004723 Protein of unknown function (DUF327); Region: DUF327; pfam03885 412694004724 Glutamate-cysteine ligase; Region: GshA; pfam08886 412694004725 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 412694004726 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 412694004727 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 412694004728 flagellar capping protein; Validated; Region: fliD; PRK06798 412694004729 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 412694004730 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 412694004731 Flagellar protein FliS; Region: FliS; cl00654 412694004732 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 412694004733 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 412694004734 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 412694004735 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 412694004736 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 412694004737 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 412694004738 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 412694004739 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 412694004740 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 412694004741 FliG C-terminal domain; Region: FliG_C; pfam01706 412694004742 flagellar assembly protein H; Validated; Region: fliH; PRK06800 412694004743 Flagellar assembly protein FliH; Region: FliH; pfam02108 412694004744 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 412694004745 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 412694004746 Walker A motif; other site 412694004747 ATP binding site [chemical binding]; other site 412694004748 Walker B motif; other site 412694004749 CRISPR-associated protein Cpf1, subtype PREFRAN; Region: cas_Cpf1; TIGR04330 412694004750 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 412694004751 flagellar basal body rod modification protein; Validated; Region: flgD; PRK06792 412694004752 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 412694004753 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 412694004754 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 412694004755 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 412694004756 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 412694004757 Response regulator receiver domain; Region: Response_reg; pfam00072 412694004758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694004759 active site 412694004760 phosphorylation site [posttranslational modification] 412694004761 intermolecular recognition site; other site 412694004762 dimerization interface [polypeptide binding]; other site 412694004763 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 412694004764 flagellin; Provisional; Region: PRK12807 412694004765 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 412694004766 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 412694004767 flagellin; Provisional; Region: PRK12808 412694004768 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 412694004769 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 412694004770 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 412694004771 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 412694004772 N-acetyl-D-glucosamine binding site [chemical binding]; other site 412694004773 catalytic residue [active] 412694004774 flagellar motor switch protein; Validated; Region: PRK06789 412694004775 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 412694004776 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 412694004777 flagellar motor switch protein; Validated; Region: PRK06788 412694004778 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 412694004779 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 412694004780 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 412694004781 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 412694004782 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 412694004783 FHIPEP family; Region: FHIPEP; pfam00771 412694004784 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK11889 412694004785 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 412694004786 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 412694004787 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 412694004788 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 412694004789 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 412694004790 Predicted transcriptional regulators [Transcription]; Region: COG1378 412694004791 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 412694004792 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 412694004793 C-terminal domain interface [polypeptide binding]; other site 412694004794 sugar binding site [chemical binding]; other site 412694004795 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 412694004796 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412694004797 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412694004798 Dienelactone hydrolase family; Region: DLH; pfam01738 412694004799 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 412694004800 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412694004801 non-specific DNA binding site [nucleotide binding]; other site 412694004802 salt bridge; other site 412694004803 sequence-specific DNA binding site [nucleotide binding]; other site 412694004804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694004805 H+ Antiporter protein; Region: 2A0121; TIGR00900 412694004806 putative substrate translocation pore; other site 412694004807 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 412694004808 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412694004809 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412694004810 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 412694004811 dimerization interface [polypeptide binding]; other site 412694004812 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 412694004813 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412694004814 Walker A/P-loop; other site 412694004815 ATP binding site [chemical binding]; other site 412694004816 Q-loop/lid; other site 412694004817 ABC transporter signature motif; other site 412694004818 Walker B; other site 412694004819 D-loop; other site 412694004820 H-loop/switch region; other site 412694004821 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 412694004822 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 412694004823 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 412694004824 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694004825 dimer interface [polypeptide binding]; other site 412694004826 conserved gate region; other site 412694004827 putative PBP binding loops; other site 412694004828 ABC-ATPase subunit interface; other site 412694004829 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694004830 dimer interface [polypeptide binding]; other site 412694004831 conserved gate region; other site 412694004832 putative PBP binding loops; other site 412694004833 ABC-ATPase subunit interface; other site 412694004834 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 412694004835 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 412694004836 Beta-Casp domain; Region: Beta-Casp; smart01027 412694004837 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 412694004838 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 412694004839 Cupin; Region: Cupin_1; smart00835 412694004840 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 412694004841 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 412694004842 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 412694004843 catalytic core [active] 412694004844 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 412694004845 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 412694004846 catalytic site [active] 412694004847 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 412694004848 MarR family; Region: MarR; pfam01047 412694004849 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 412694004850 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 412694004851 active site 412694004852 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 412694004853 dimer interface [polypeptide binding]; other site 412694004854 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 412694004855 Ligand Binding Site [chemical binding]; other site 412694004856 Molecular Tunnel; other site 412694004857 RNA polymerase factor sigma-70; Validated; Region: PRK06811 412694004858 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412694004859 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 412694004860 DNA binding residues [nucleotide binding] 412694004861 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 412694004862 VPS10 domain; Region: VPS10; smart00602 412694004863 VPS10 domain; Region: VPS10; smart00602 412694004864 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 412694004865 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412694004866 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 412694004867 DNA-binding site [nucleotide binding]; DNA binding site 412694004868 FCD domain; Region: FCD; pfam07729 412694004869 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 412694004870 EamA-like transporter family; Region: EamA; pfam00892 412694004871 EamA-like transporter family; Region: EamA; pfam00892 412694004872 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 412694004873 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 412694004874 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 412694004875 Predicted permeases [General function prediction only]; Region: COG0701 412694004876 TIGR03943 family protein; Region: TIGR03943 412694004877 Methyltransferase domain; Region: Methyltransf_24; pfam13578 412694004878 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 412694004879 fumarate hydratase; Reviewed; Region: fumC; PRK00485 412694004880 Class II fumarases; Region: Fumarase_classII; cd01362 412694004881 active site 412694004882 tetramer interface [polypeptide binding]; other site 412694004883 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 412694004884 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 412694004885 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 412694004886 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 412694004887 active site pocket [active] 412694004888 oxyanion hole [active] 412694004889 catalytic triad [active] 412694004890 active site nucleophile [active] 412694004891 Protein of unknown function (DUF3942); Region: DUF3942; pfam13078 412694004892 Penicillinase repressor; Region: Pencillinase_R; pfam03965 412694004893 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 412694004894 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 412694004895 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 412694004896 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 412694004897 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 412694004898 catalytic residues [active] 412694004899 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 412694004900 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412694004901 sequence-specific DNA binding site [nucleotide binding]; other site 412694004902 salt bridge; other site 412694004903 Cupin domain; Region: Cupin_2; pfam07883 412694004904 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 412694004905 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 412694004906 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 412694004907 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 412694004908 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412694004909 catalytic residue [active] 412694004910 Protein of unknown function (DUF445); Region: DUF445; pfam04286 412694004911 RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642 412694004912 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412694004913 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 412694004914 DNA binding residues [nucleotide binding] 412694004915 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 412694004916 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694004917 active site 412694004918 phosphorylation site [posttranslational modification] 412694004919 intermolecular recognition site; other site 412694004920 dimerization interface [polypeptide binding]; other site 412694004921 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 412694004922 DNA binding residues [nucleotide binding] 412694004923 dimerization interface [polypeptide binding]; other site 412694004924 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 412694004925 Histidine kinase; Region: HisKA_3; pfam07730 412694004926 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 412694004927 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412694004928 Walker A/P-loop; other site 412694004929 ATP binding site [chemical binding]; other site 412694004930 Q-loop/lid; other site 412694004931 ABC transporter signature motif; other site 412694004932 Walker B; other site 412694004933 D-loop; other site 412694004934 H-loop/switch region; other site 412694004935 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 412694004936 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 412694004937 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 412694004938 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 412694004939 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 412694004940 PLD-like domain; Region: PLDc_2; pfam13091 412694004941 putative active site [active] 412694004942 catalytic site [active] 412694004943 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 412694004944 PLD-like domain; Region: PLDc_2; pfam13091 412694004945 putative active site [active] 412694004946 catalytic site [active] 412694004947 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 412694004948 putative nucleotide binding site [chemical binding]; other site 412694004949 uridine monophosphate binding site [chemical binding]; other site 412694004950 homohexameric interface [polypeptide binding]; other site 412694004951 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 412694004952 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 412694004953 aspartate ammonia-lyase; Provisional; Region: PRK14515 412694004954 Aspartase; Region: Aspartase; cd01357 412694004955 active sites [active] 412694004956 tetramer interface [polypeptide binding]; other site 412694004957 malate dehydrogenase; Provisional; Region: PRK13529 412694004958 Malic enzyme, N-terminal domain; Region: malic; pfam00390 412694004959 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 412694004960 NAD(P) binding site [chemical binding]; other site 412694004961 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412694004962 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694004963 ATP binding site [chemical binding]; other site 412694004964 Mg2+ binding site [ion binding]; other site 412694004965 G-X-G motif; other site 412694004966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694004967 Response regulator receiver domain; Region: Response_reg; pfam00072 412694004968 active site 412694004969 phosphorylation site [posttranslational modification] 412694004970 intermolecular recognition site; other site 412694004971 dimerization interface [polypeptide binding]; other site 412694004972 YcbB domain; Region: YcbB; pfam08664 412694004973 SWIM zinc finger; Region: SWIM; pfam04434 412694004974 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 412694004975 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 412694004976 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 412694004977 ATP binding site [chemical binding]; other site 412694004978 putative Mg++ binding site [ion binding]; other site 412694004979 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412694004980 nucleotide binding region [chemical binding]; other site 412694004981 ATP-binding site [chemical binding]; other site 412694004982 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 412694004983 dimer interface [polypeptide binding]; other site 412694004984 active site 412694004985 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 412694004986 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412694004987 non-specific DNA binding site [nucleotide binding]; other site 412694004988 salt bridge; other site 412694004989 sequence-specific DNA binding site [nucleotide binding]; other site 412694004990 aspartate kinase; Reviewed; Region: PRK06635 412694004991 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 412694004992 putative nucleotide binding site [chemical binding]; other site 412694004993 putative catalytic residues [active] 412694004994 putative Mg ion binding site [ion binding]; other site 412694004995 putative aspartate binding site [chemical binding]; other site 412694004996 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 412694004997 putative allosteric regulatory site; other site 412694004998 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 412694004999 putative allosteric regulatory residue; other site 412694005000 DoxX-like family; Region: DoxX_3; pfam13781 412694005001 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 412694005002 YndJ-like protein; Region: YndJ; pfam14158 412694005003 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 412694005004 putative active site [active] 412694005005 nucleotide binding site [chemical binding]; other site 412694005006 nudix motif; other site 412694005007 putative metal binding site [ion binding]; other site 412694005008 S-layer homology domain; Region: SLH; pfam00395 412694005009 S-layer homology domain; Region: SLH; pfam00395 412694005010 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 412694005011 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 412694005012 active site 412694005013 metal binding site [ion binding]; metal-binding site 412694005014 S-layer homology domain; Region: SLH; pfam00395 412694005015 S-layer homology domain; Region: SLH; pfam00395 412694005016 S-layer homology domain; Region: SLH; pfam00395 412694005017 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 412694005018 Carbon starvation protein CstA; Region: CstA; pfam02554 412694005019 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 412694005020 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 412694005021 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 412694005022 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694005023 Major Facilitator Superfamily; Region: MFS_1; pfam07690 412694005024 putative substrate translocation pore; other site 412694005025 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 412694005026 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 412694005027 dimer interface [polypeptide binding]; other site 412694005028 active site 412694005029 CoA binding pocket [chemical binding]; other site 412694005030 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 412694005031 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 412694005032 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 412694005033 HflX GTPase family; Region: HflX; cd01878 412694005034 G1 box; other site 412694005035 GTP/Mg2+ binding site [chemical binding]; other site 412694005036 Switch I region; other site 412694005037 G2 box; other site 412694005038 G3 box; other site 412694005039 Switch II region; other site 412694005040 G4 box; other site 412694005041 G5 box; other site 412694005042 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 412694005043 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 412694005044 peptide binding site [polypeptide binding]; other site 412694005045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694005046 Major Facilitator Superfamily; Region: MFS_1; pfam07690 412694005047 putative substrate translocation pore; other site 412694005048 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 412694005049 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 412694005050 dimer interface [polypeptide binding]; other site 412694005051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694005052 catalytic residue [active] 412694005053 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694005054 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 412694005055 Coenzyme A binding pocket [chemical binding]; other site 412694005056 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 412694005057 stage V sporulation protein B; Region: spore_V_B; TIGR02900 412694005058 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 412694005059 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 412694005060 Na2 binding site [ion binding]; other site 412694005061 putative substrate binding site 1 [chemical binding]; other site 412694005062 Na binding site 1 [ion binding]; other site 412694005063 putative substrate binding site 2 [chemical binding]; other site 412694005064 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 412694005065 Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956 412694005066 NodB motif; other site 412694005067 putative active site [active] 412694005068 putative catalytic site [active] 412694005069 putative Zn binding site [ion binding]; other site 412694005070 Mor transcription activator family; Region: Mor; cl02360 412694005071 Predicted membrane protein [Function unknown]; Region: COG2323 412694005072 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 412694005073 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 412694005074 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 412694005075 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 412694005076 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 412694005077 methionine sulfoxide reductase A; Provisional; Region: PRK14054 412694005078 short chain dehydrogenase; Provisional; Region: PRK12747 412694005079 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 412694005080 NADP binding site [chemical binding]; other site 412694005081 homodimer interface [polypeptide binding]; other site 412694005082 active site 412694005083 substrate binding site [chemical binding]; other site 412694005084 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 412694005085 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 412694005086 homodimer interface [polypeptide binding]; other site 412694005087 substrate-cofactor binding pocket; other site 412694005088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694005089 catalytic residue [active] 412694005090 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06725 412694005091 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 412694005092 PYR/PP interface [polypeptide binding]; other site 412694005093 dimer interface [polypeptide binding]; other site 412694005094 TPP binding site [chemical binding]; other site 412694005095 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 412694005096 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 412694005097 TPP-binding site [chemical binding]; other site 412694005098 dimer interface [polypeptide binding]; other site 412694005099 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 412694005100 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 412694005101 putative valine binding site [chemical binding]; other site 412694005102 dimer interface [polypeptide binding]; other site 412694005103 ketol-acid reductoisomerase; Provisional; Region: PRK05479 412694005104 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 412694005105 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 412694005106 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 412694005107 threonine dehydratase; Validated; Region: PRK08639 412694005108 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 412694005109 tetramer interface [polypeptide binding]; other site 412694005110 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694005111 catalytic residue [active] 412694005112 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 412694005113 putative Ile/Val binding site [chemical binding]; other site 412694005114 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 412694005115 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 412694005116 putative active site [active] 412694005117 putative metal binding site [ion binding]; other site 412694005118 Protein of unknown function (DUF554); Region: DUF554; pfam04474 412694005119 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694005120 Coenzyme A binding pocket [chemical binding]; other site 412694005121 drug efflux system protein MdtG; Provisional; Region: PRK09874 412694005122 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694005123 putative substrate translocation pore; other site 412694005124 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 412694005125 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 412694005126 putative active site [active] 412694005127 metal binding site [ion binding]; metal-binding site 412694005128 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 412694005129 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 412694005130 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 412694005131 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 412694005132 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 412694005133 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 412694005134 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 412694005135 Beta-lactamase; Region: Beta-lactamase; pfam00144 412694005136 LytTr DNA-binding domain; Region: LytTR; pfam04397 412694005137 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 412694005138 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 412694005139 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 412694005140 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 412694005141 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 412694005142 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694005143 Coenzyme A binding pocket [chemical binding]; other site 412694005144 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 412694005145 5-methylthioadenosine/S-adenosylhomocysteine deaminase; Provisional; Region: PRK15493 412694005146 active site 412694005147 putative substrate binding pocket [chemical binding]; other site 412694005148 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 412694005149 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 412694005150 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 412694005151 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 412694005152 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 412694005153 peptide binding site [polypeptide binding]; other site 412694005154 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 412694005155 hypothetical protein; Provisional; Region: PRK06922 412694005156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694005157 S-adenosylmethionine binding site [chemical binding]; other site 412694005158 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 412694005159 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412694005160 FeS/SAM binding site; other site 412694005161 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 412694005162 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 412694005163 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694005164 Coenzyme A binding pocket [chemical binding]; other site 412694005165 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412694005166 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694005167 active site 412694005168 phosphorylation site [posttranslational modification] 412694005169 intermolecular recognition site; other site 412694005170 dimerization interface [polypeptide binding]; other site 412694005171 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412694005172 DNA binding site [nucleotide binding] 412694005173 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412694005174 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412694005175 dimerization interface [polypeptide binding]; other site 412694005176 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694005177 dimer interface [polypeptide binding]; other site 412694005178 phosphorylation site [posttranslational modification] 412694005179 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694005180 ATP binding site [chemical binding]; other site 412694005181 Mg2+ binding site [ion binding]; other site 412694005182 G-X-G motif; other site 412694005183 Peptidase family M23; Region: Peptidase_M23; pfam01551 412694005184 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 412694005185 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 412694005186 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 412694005187 manganese transport protein MntH; Reviewed; Region: PRK00701 412694005188 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 412694005189 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 412694005190 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 412694005191 active site residue [active] 412694005192 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 412694005193 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 412694005194 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 412694005195 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 412694005196 Amino acid permease; Region: AA_permease_2; pfam13520 412694005197 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 412694005198 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 412694005199 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 412694005200 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 412694005201 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 412694005202 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412694005203 Walker A/P-loop; other site 412694005204 ATP binding site [chemical binding]; other site 412694005205 Q-loop/lid; other site 412694005206 ABC transporter signature motif; other site 412694005207 Walker B; other site 412694005208 D-loop; other site 412694005209 H-loop/switch region; other site 412694005210 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 412694005211 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 412694005212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 412694005213 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 412694005214 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412694005215 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694005216 active site 412694005217 phosphorylation site [posttranslational modification] 412694005218 intermolecular recognition site; other site 412694005219 dimerization interface [polypeptide binding]; other site 412694005220 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412694005221 DNA binding site [nucleotide binding] 412694005222 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412694005223 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694005224 dimer interface [polypeptide binding]; other site 412694005225 phosphorylation site [posttranslational modification] 412694005226 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694005227 ATP binding site [chemical binding]; other site 412694005228 Mg2+ binding site [ion binding]; other site 412694005229 G-X-G motif; other site 412694005230 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 412694005231 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 412694005232 DNA binding residues [nucleotide binding] 412694005233 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 412694005234 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 412694005235 intersubunit interface [polypeptide binding]; other site 412694005236 active site 412694005237 catalytic residue [active] 412694005238 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 412694005239 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 412694005240 Nucleoside recognition; Region: Gate; pfam07670 412694005241 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 412694005242 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 412694005243 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 412694005244 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 412694005245 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 412694005246 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 412694005247 active site 412694005248 catalytic motif [active] 412694005249 Zn binding site [ion binding]; other site 412694005250 hypothetical protein; Provisional; Region: PRK01631 412694005251 Family description; Region: DsbD_2; pfam13386 412694005252 VPS10 domain; Region: VPS10; smart00602 412694005253 proline aminopeptidase P II; Provisional; Region: PRK10879 412694005254 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 412694005255 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 412694005256 active site 412694005257 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 412694005258 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 412694005259 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 412694005260 Multicopper oxidase; Region: Cu-oxidase; pfam00394 412694005261 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 412694005262 Bacterial SH3 domain; Region: SH3_3; pfam08239 412694005263 Bacterial SH3 domain; Region: SH3_3; pfam08239 412694005264 Bacterial SH3 domain; Region: SH3_3; pfam08239 412694005265 Bacterial SH3 domain; Region: SH3_3; pfam08239 412694005266 Bacterial SH3 domain; Region: SH3_3; pfam08239 412694005267 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 412694005268 Peptidase family M23; Region: Peptidase_M23; pfam01551 412694005269 DNA topoisomerase III; Provisional; Region: PRK07726 412694005270 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 412694005271 active site 412694005272 putative interdomain interaction site [polypeptide binding]; other site 412694005273 putative metal-binding site [ion binding]; other site 412694005274 putative nucleotide binding site [chemical binding]; other site 412694005275 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 412694005276 domain I; other site 412694005277 DNA binding groove [nucleotide binding] 412694005278 phosphate binding site [ion binding]; other site 412694005279 domain II; other site 412694005280 domain III; other site 412694005281 nucleotide binding site [chemical binding]; other site 412694005282 catalytic site [active] 412694005283 domain IV; other site 412694005284 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 412694005285 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 412694005286 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 412694005287 Sodium Bile acid symporter family; Region: SBF; cl17470 412694005288 azoreductase; Provisional; Region: PRK13555 412694005289 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 412694005290 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 412694005291 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 412694005292 dimer interface [polypeptide binding]; other site 412694005293 substrate binding site [chemical binding]; other site 412694005294 metal binding site [ion binding]; metal-binding site 412694005295 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 412694005296 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 412694005297 YtkA-like; Region: YtkA; pfam13115 412694005298 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 412694005299 EamA-like transporter family; Region: EamA; pfam00892 412694005300 EamA-like transporter family; Region: EamA; pfam00892 412694005301 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412694005302 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412694005303 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 412694005304 dimerization interface [polypeptide binding]; other site 412694005305 Predicted transcriptional regulator [Transcription]; Region: COG1959 412694005306 Transcriptional regulator; Region: Rrf2; pfam02082 412694005307 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 412694005308 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 412694005309 catalytic residues [active] 412694005310 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 412694005311 dimer interface [polypeptide binding]; other site 412694005312 FMN binding site [chemical binding]; other site 412694005313 amidase; Provisional; Region: PRK06707 412694005314 Amidase; Region: Amidase; cl11426 412694005315 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 412694005316 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 412694005317 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 412694005318 tetramer (dimer of dimers) interface [polypeptide binding]; other site 412694005319 NAD binding site [chemical binding]; other site 412694005320 dimer interface [polypeptide binding]; other site 412694005321 substrate binding site [chemical binding]; other site 412694005322 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 412694005323 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 412694005324 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 412694005325 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 412694005326 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 412694005327 S-layer homology domain; Region: SLH; pfam00395 412694005328 S-layer homology domain; Region: SLH; pfam00395 412694005329 S-layer homology domain; Region: SLH; pfam00395 412694005330 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412694005331 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412694005332 acyl-CoA synthetase; Validated; Region: PRK06839 412694005333 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 412694005334 acyl-activating enzyme (AAE) consensus motif; other site 412694005335 putative AMP binding site [chemical binding]; other site 412694005336 putative active site [active] 412694005337 putative CoA binding site [chemical binding]; other site 412694005338 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 412694005339 dimer interaction site [polypeptide binding]; other site 412694005340 substrate-binding tunnel; other site 412694005341 active site 412694005342 catalytic site [active] 412694005343 substrate binding site [chemical binding]; other site 412694005344 hypothetical protein; Validated; Region: PRK06840 412694005345 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 412694005346 active site 412694005347 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 412694005348 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 412694005349 putative ligand binding site [chemical binding]; other site 412694005350 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 412694005351 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 412694005352 Walker A/P-loop; other site 412694005353 ATP binding site [chemical binding]; other site 412694005354 Q-loop/lid; other site 412694005355 ABC transporter signature motif; other site 412694005356 Walker B; other site 412694005357 D-loop; other site 412694005358 H-loop/switch region; other site 412694005359 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 412694005360 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 412694005361 Walker A/P-loop; other site 412694005362 ATP binding site [chemical binding]; other site 412694005363 Q-loop/lid; other site 412694005364 ABC transporter signature motif; other site 412694005365 Walker B; other site 412694005366 D-loop; other site 412694005367 H-loop/switch region; other site 412694005368 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 412694005369 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 412694005370 TM-ABC transporter signature motif; other site 412694005371 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 412694005372 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 412694005373 TM-ABC transporter signature motif; other site 412694005374 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412694005375 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 412694005376 LysR substrate binding domain; Region: LysR_substrate; pfam03466 412694005377 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 412694005378 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 412694005379 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412694005380 putative Zn2+ binding site [ion binding]; other site 412694005381 putative DNA binding site [nucleotide binding]; other site 412694005382 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 412694005383 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 412694005384 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 412694005385 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 412694005386 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 412694005387 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 412694005388 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 412694005389 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 412694005390 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 412694005391 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 412694005392 Walker A/P-loop; other site 412694005393 ATP binding site [chemical binding]; other site 412694005394 Q-loop/lid; other site 412694005395 ABC transporter signature motif; other site 412694005396 Walker B; other site 412694005397 D-loop; other site 412694005398 H-loop/switch region; other site 412694005399 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 412694005400 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 412694005401 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 412694005402 Walker A/P-loop; other site 412694005403 ATP binding site [chemical binding]; other site 412694005404 Q-loop/lid; other site 412694005405 ABC transporter signature motif; other site 412694005406 Walker B; other site 412694005407 D-loop; other site 412694005408 H-loop/switch region; other site 412694005409 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 412694005410 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 412694005411 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 412694005412 dimer interface [polypeptide binding]; other site 412694005413 FMN binding site [chemical binding]; other site 412694005414 Bacterial SH3 domain; Region: SH3_3; pfam08239 412694005415 Bacterial SH3 domain; Region: SH3_3; pfam08239 412694005416 Bacterial SH3 domain; Region: SH3_3; pfam08239 412694005417 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 412694005418 NlpC/P60 family; Region: NLPC_P60; pfam00877 412694005419 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 412694005420 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 412694005421 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 412694005422 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412694005423 Walker A/P-loop; other site 412694005424 ATP binding site [chemical binding]; other site 412694005425 Q-loop/lid; other site 412694005426 ABC transporter signature motif; other site 412694005427 Walker B; other site 412694005428 D-loop; other site 412694005429 H-loop/switch region; other site 412694005430 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412694005431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694005432 active site 412694005433 phosphorylation site [posttranslational modification] 412694005434 intermolecular recognition site; other site 412694005435 dimerization interface [polypeptide binding]; other site 412694005436 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412694005437 DNA binding site [nucleotide binding] 412694005438 Protein of unknown function (DUF475); Region: DUF475; cl17481 412694005439 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412694005440 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412694005441 dimerization interface [polypeptide binding]; other site 412694005442 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694005443 dimer interface [polypeptide binding]; other site 412694005444 phosphorylation site [posttranslational modification] 412694005445 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694005446 ATP binding site [chemical binding]; other site 412694005447 Mg2+ binding site [ion binding]; other site 412694005448 G-X-G motif; other site 412694005449 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 412694005450 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 412694005451 classical (c) SDRs; Region: SDR_c; cd05233 412694005452 NAD(P) binding site [chemical binding]; other site 412694005453 active site 412694005454 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 412694005455 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694005456 S-adenosylmethionine binding site [chemical binding]; other site 412694005457 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 412694005458 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 412694005459 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 412694005460 NodB motif; other site 412694005461 active site 412694005462 catalytic site [active] 412694005463 metal binding site [ion binding]; metal-binding site 412694005464 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_33; cd04692 412694005465 nudix motif; other site 412694005466 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 412694005467 homoserine dehydrogenase; Provisional; Region: PRK06349 412694005468 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 412694005469 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 412694005470 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 412694005471 threonine synthase; Reviewed; Region: PRK06721 412694005472 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 412694005473 homodimer interface [polypeptide binding]; other site 412694005474 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694005475 catalytic residue [active] 412694005476 homoserine kinase; Provisional; Region: PRK01212 412694005477 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 412694005478 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 412694005479 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 412694005480 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 412694005481 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412694005482 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694005483 active site 412694005484 phosphorylation site [posttranslational modification] 412694005485 intermolecular recognition site; other site 412694005486 dimerization interface [polypeptide binding]; other site 412694005487 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412694005488 DNA binding site [nucleotide binding] 412694005489 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412694005490 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412694005491 dimerization interface [polypeptide binding]; other site 412694005492 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694005493 dimer interface [polypeptide binding]; other site 412694005494 phosphorylation site [posttranslational modification] 412694005495 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694005496 ATP binding site [chemical binding]; other site 412694005497 Mg2+ binding site [ion binding]; other site 412694005498 G-X-G motif; other site 412694005499 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 412694005500 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 412694005501 NodB motif; other site 412694005502 active site 412694005503 catalytic site [active] 412694005504 Zn binding site [ion binding]; other site 412694005505 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 412694005506 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 412694005507 MgtC family; Region: MgtC; pfam02308 412694005508 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 412694005509 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694005510 Coenzyme A binding pocket [chemical binding]; other site 412694005511 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 412694005512 IucA / IucC family; Region: IucA_IucC; pfam04183 412694005513 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 412694005514 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 412694005515 IucA / IucC family; Region: IucA_IucC; pfam04183 412694005516 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 412694005517 acyl-CoA synthetase; Validated; Region: PRK08308 412694005518 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 412694005519 acyl-activating enzyme (AAE) consensus motif; other site 412694005520 AMP binding site [chemical binding]; other site 412694005521 active site 412694005522 CoA binding site [chemical binding]; other site 412694005523 acyl carrier protein; Provisional; Region: PRK07639 412694005524 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 412694005525 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 412694005526 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694005527 Major Facilitator Superfamily; Region: MFS_1; pfam07690 412694005528 putative substrate translocation pore; other site 412694005529 Lysine efflux permease [General function prediction only]; Region: COG1279 412694005530 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 412694005531 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412694005532 DNA-binding site [nucleotide binding]; DNA binding site 412694005533 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412694005534 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694005535 homodimer interface [polypeptide binding]; other site 412694005536 catalytic residue [active] 412694005537 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 412694005538 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 412694005539 active site 412694005540 nucleophile elbow; other site 412694005541 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 412694005542 Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279 412694005543 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 412694005544 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 412694005545 nudix motif; other site 412694005546 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 412694005547 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 412694005548 homodimer interface [polypeptide binding]; other site 412694005549 NAD binding pocket [chemical binding]; other site 412694005550 ATP binding pocket [chemical binding]; other site 412694005551 Mg binding site [ion binding]; other site 412694005552 active-site loop [active] 412694005553 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 412694005554 FtsX-like permease family; Region: FtsX; pfam02687 412694005555 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 412694005556 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 412694005557 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 412694005558 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 412694005559 active site 412694005560 catalytic residues [active] 412694005561 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412694005562 dimerization interface [polypeptide binding]; other site 412694005563 putative DNA binding site [nucleotide binding]; other site 412694005564 putative Zn2+ binding site [ion binding]; other site 412694005565 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 412694005566 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 412694005567 active site 412694005568 catalytic tetrad [active] 412694005569 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 412694005570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694005571 putative substrate translocation pore; other site 412694005572 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 412694005573 Protein of unknown function (DUF664); Region: DUF664; pfam04978 412694005574 DinB superfamily; Region: DinB_2; pfam12867 412694005575 GTPase RsgA; Reviewed; Region: PRK01889 412694005576 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 412694005577 RNA binding site [nucleotide binding]; other site 412694005578 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 412694005579 GTPase/Zn-binding domain interface [polypeptide binding]; other site 412694005580 GTP/Mg2+ binding site [chemical binding]; other site 412694005581 G4 box; other site 412694005582 G5 box; other site 412694005583 G1 box; other site 412694005584 Switch I region; other site 412694005585 G2 box; other site 412694005586 G3 box; other site 412694005587 Switch II region; other site 412694005588 Tar ligand binding domain homologue; Region: TarH; pfam02203 412694005589 Cache domain; Region: Cache_1; pfam02743 412694005590 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 412694005591 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412694005592 dimerization interface [polypeptide binding]; other site 412694005593 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 412694005594 dimer interface [polypeptide binding]; other site 412694005595 putative CheW interface [polypeptide binding]; other site 412694005596 Protein of unknown function (DUF3979); Region: DUF3979; pfam13141 412694005597 Uncharacterized membrane protein [Function unknown]; Region: COG3949 412694005598 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 412694005599 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 412694005600 dimerization interface [polypeptide binding]; other site 412694005601 DPS ferroxidase diiron center [ion binding]; other site 412694005602 ion pore; other site 412694005603 Protein of unknown function (DUF3939); Region: DUF3939; pfam13075 412694005604 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 412694005605 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 412694005606 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 412694005607 Protein of unknown function (DUF3896); Region: DUF3896; pfam13035 412694005608 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 412694005609 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 412694005610 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 412694005611 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 412694005612 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 412694005613 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 412694005614 active site 412694005615 catalytic tetrad [active] 412694005616 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 412694005617 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 412694005618 P-loop, Walker A motif; other site 412694005619 Base recognition motif; other site 412694005620 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 412694005621 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 412694005622 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694005623 Coenzyme A binding pocket [chemical binding]; other site 412694005624 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 412694005625 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 412694005626 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 412694005627 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 412694005628 metal binding site [ion binding]; metal-binding site 412694005629 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 412694005630 NADH(P)-binding; Region: NAD_binding_10; pfam13460 412694005631 NAD binding site [chemical binding]; other site 412694005632 active site 412694005633 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 412694005634 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 412694005635 active site 412694005636 FMN binding site [chemical binding]; other site 412694005637 substrate binding site [chemical binding]; other site 412694005638 homotetramer interface [polypeptide binding]; other site 412694005639 catalytic residue [active] 412694005640 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 412694005641 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 412694005642 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 412694005643 DNA binding site [nucleotide binding] 412694005644 active site 412694005645 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 412694005646 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 412694005647 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 412694005648 peptide binding site [polypeptide binding]; other site 412694005649 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 412694005650 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 412694005651 active site 412694005652 metal binding site [ion binding]; metal-binding site 412694005653 short chain dehydrogenase; Provisional; Region: PRK08309 412694005654 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 412694005655 catalytic core [active] 412694005656 CotH protein; Region: CotH; pfam08757 412694005657 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 412694005658 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 412694005659 nudix motif; other site 412694005660 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 412694005661 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 412694005662 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 412694005663 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 412694005664 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 412694005665 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 412694005666 Cl binding site [ion binding]; other site 412694005667 oligomer interface [polypeptide binding]; other site 412694005668 Predicted permeases [General function prediction only]; Region: COG0701 412694005669 Predicted membrane protein [Function unknown]; Region: COG3689 412694005670 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 412694005671 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 412694005672 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 412694005673 putative active site [active] 412694005674 catalytic site [active] 412694005675 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 412694005676 putative active site [active] 412694005677 catalytic site [active] 412694005678 Coat F domain; Region: Coat_F; pfam07875 412694005679 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 412694005680 NADH(P)-binding; Region: NAD_binding_10; pfam13460 412694005681 NAD binding site [chemical binding]; other site 412694005682 substrate binding site [chemical binding]; other site 412694005683 putative active site [active] 412694005684 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 412694005685 Domain of unknown function DUF21; Region: DUF21; pfam01595 412694005686 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 412694005687 Transporter associated domain; Region: CorC_HlyC; smart01091 412694005688 FOG: CBS domain [General function prediction only]; Region: COG0517 412694005689 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 412694005690 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 412694005691 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 412694005692 dimer interface [polypeptide binding]; other site 412694005693 putative tRNA-binding site [nucleotide binding]; other site 412694005694 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 412694005695 DinB superfamily; Region: DinB_2; pfam12867 412694005696 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 412694005697 stage II sporulation protein P; Region: spore_II_P; TIGR02867 412694005698 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 412694005699 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694005700 Coenzyme A binding pocket [chemical binding]; other site 412694005701 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 412694005702 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 412694005703 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 412694005704 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belong to this superfamily requires a divalent cation, such as Mg2+ or Mn2+ for their activity and contain a highly...; Region: Nudix_Hydrolase_6; cd04663 412694005705 nudix motif; other site 412694005706 amidase; Provisional; Region: PRK06828 412694005707 Amidase; Region: Amidase; pfam01425 412694005708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694005709 putative substrate translocation pore; other site 412694005710 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 412694005711 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 412694005712 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 412694005713 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 412694005714 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 412694005715 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 412694005716 Transcriptional regulator [Transcription]; Region: IclR; COG1414 412694005717 Bacterial transcriptional regulator; Region: IclR; pfam01614 412694005718 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 412694005719 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 412694005720 active site 412694005721 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 412694005722 Amidohydrolase; Region: Amidohydro_2; pfam04909 412694005723 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 412694005724 homotrimer interaction site [polypeptide binding]; other site 412694005725 putative active site [active] 412694005726 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 412694005727 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 412694005728 NAD binding site [chemical binding]; other site 412694005729 catalytic residues [active] 412694005730 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 412694005731 acetaldehyde dehydrogenase; Validated; Region: PRK08300 412694005732 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 412694005733 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 412694005734 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 412694005735 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 412694005736 active site 412694005737 catalytic residues [active] 412694005738 metal binding site [ion binding]; metal-binding site 412694005739 DmpG-like communication domain; Region: DmpG_comm; pfam07836 412694005740 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 412694005741 4-oxalocrotonate tautomerase; Provisional; Region: PRK01964 412694005742 active site 1 [active] 412694005743 dimer interface [polypeptide binding]; other site 412694005744 hexamer interface [polypeptide binding]; other site 412694005745 active site 2 [active] 412694005746 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 412694005747 catalytic core [active] 412694005748 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412694005749 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 412694005750 active site 412694005751 motif I; other site 412694005752 motif II; other site 412694005753 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412694005754 DinB superfamily; Region: DinB_2; pfam12867 412694005755 DinB family; Region: DinB; cl17821 412694005756 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 412694005757 alanine racemase; Reviewed; Region: alr; PRK00053 412694005758 active site 412694005759 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 412694005760 dimer interface [polypeptide binding]; other site 412694005761 substrate binding site [chemical binding]; other site 412694005762 catalytic residues [active] 412694005763 Methyltransferase domain; Region: Methyltransf_31; pfam13847 412694005764 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694005765 S-adenosylmethionine binding site [chemical binding]; other site 412694005766 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694005767 Coenzyme A binding pocket [chemical binding]; other site 412694005768 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694005769 Coenzyme A binding pocket [chemical binding]; other site 412694005770 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 412694005771 glycosyltransferase, MGT family; Region: MGT; TIGR01426 412694005772 active site 412694005773 TDP-binding site; other site 412694005774 acceptor substrate-binding pocket; other site 412694005775 homodimer interface [polypeptide binding]; other site 412694005776 Uncharacterized conserved protein [Function unknown]; Region: COG1284 412694005777 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 412694005778 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 412694005779 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 412694005780 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412694005781 DNA-binding site [nucleotide binding]; DNA binding site 412694005782 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412694005783 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694005784 homodimer interface [polypeptide binding]; other site 412694005785 catalytic residue [active] 412694005786 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694005787 Coenzyme A binding pocket [chemical binding]; other site 412694005788 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 412694005789 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 412694005790 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694005791 Coenzyme A binding pocket [chemical binding]; other site 412694005792 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 412694005793 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 412694005794 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 412694005795 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694005796 Coenzyme A binding pocket [chemical binding]; other site 412694005797 Cupin domain; Region: Cupin_2; cl17218 412694005798 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 412694005799 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 412694005800 Methyltransferase domain; Region: Methyltransf_23; pfam13489 412694005801 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694005802 S-adenosylmethionine binding site [chemical binding]; other site 412694005803 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 412694005804 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 412694005805 Potassium binding sites [ion binding]; other site 412694005806 Cesium cation binding sites [ion binding]; other site 412694005807 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 412694005808 DEAD-like helicases superfamily; Region: DEXDc; smart00487 412694005809 ATP binding site [chemical binding]; other site 412694005810 putative Mg++ binding site [ion binding]; other site 412694005811 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412694005812 nucleotide binding region [chemical binding]; other site 412694005813 ATP-binding site [chemical binding]; other site 412694005814 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 412694005815 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 412694005816 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 412694005817 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 412694005818 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 412694005819 NADP binding site [chemical binding]; other site 412694005820 dimer interface [polypeptide binding]; other site 412694005821 RNA polymerase sigma factor; Provisional; Region: PRK12543 412694005822 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412694005823 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 412694005824 DNA binding residues [nucleotide binding] 412694005825 Domain of unknown function (DUF3600); Region: DUF3600; pfam12207 412694005826 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 412694005827 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 412694005828 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 412694005829 catalytic residues [active] 412694005830 dimer interface [polypeptide binding]; other site 412694005831 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 412694005832 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 412694005833 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 412694005834 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 412694005835 Protein of unknown function DUF58; Region: DUF58; pfam01882 412694005836 MoxR-like ATPases [General function prediction only]; Region: COG0714 412694005837 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412694005838 Walker A motif; other site 412694005839 ATP binding site [chemical binding]; other site 412694005840 Walker B motif; other site 412694005841 arginine finger; other site 412694005842 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 412694005843 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 412694005844 [4Fe-4S] binding site [ion binding]; other site 412694005845 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 412694005846 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 412694005847 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 412694005848 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 412694005849 molybdopterin cofactor binding site; other site 412694005850 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 412694005851 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 412694005852 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 412694005853 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 412694005854 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 412694005855 ligand binding site [chemical binding]; other site 412694005856 flexible hinge region; other site 412694005857 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 412694005858 putative switch regulator; other site 412694005859 non-specific DNA interactions [nucleotide binding]; other site 412694005860 DNA binding site [nucleotide binding] 412694005861 sequence specific DNA binding site [nucleotide binding]; other site 412694005862 putative cAMP binding site [chemical binding]; other site 412694005863 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 412694005864 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412694005865 FeS/SAM binding site; other site 412694005866 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 412694005867 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 412694005868 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 412694005869 ATP binding site [chemical binding]; other site 412694005870 substrate interface [chemical binding]; other site 412694005871 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 412694005872 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 412694005873 dimer interface [polypeptide binding]; other site 412694005874 putative functional site; other site 412694005875 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 412694005876 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 412694005877 MPT binding site; other site 412694005878 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 412694005879 MoaE homodimer interface [polypeptide binding]; other site 412694005880 MoaD interaction [polypeptide binding]; other site 412694005881 active site residues [active] 412694005882 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 412694005883 MoaE interaction surface [polypeptide binding]; other site 412694005884 MoeB interaction surface [polypeptide binding]; other site 412694005885 thiocarboxylated glycine; other site 412694005886 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 412694005887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694005888 putative substrate translocation pore; other site 412694005889 Predicted permeases [General function prediction only]; Region: COG0679 412694005890 precorrin-2 dehydrogenase; Validated; Region: PRK06719 412694005891 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 412694005892 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 412694005893 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 412694005894 putative active site [active] 412694005895 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 412694005896 putative active site [active] 412694005897 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 412694005898 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 412694005899 active site 412694005900 SAM binding site [chemical binding]; other site 412694005901 homodimer interface [polypeptide binding]; other site 412694005902 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 412694005903 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 412694005904 [2Fe-2S] cluster binding site [ion binding]; other site 412694005905 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 412694005906 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 412694005907 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 412694005908 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 412694005909 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 412694005910 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 412694005911 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 412694005912 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 412694005913 Hemerythrin-like domain; Region: Hr-like; cd12108 412694005914 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 412694005915 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 412694005916 PGAP1-like protein; Region: PGAP1; pfam07819 412694005917 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 412694005918 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 412694005919 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 412694005920 nucleophilic elbow; other site 412694005921 catalytic triad; other site 412694005922 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 412694005923 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 412694005924 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 412694005925 Zn2+ binding site [ion binding]; other site 412694005926 Mg2+ binding site [ion binding]; other site 412694005927 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 412694005928 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 412694005929 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 412694005930 ABC transporter; Region: ABC_tran_2; pfam12848 412694005931 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 412694005932 Bax inhibitor 1 like; Region: BaxI_1; cl17691 412694005933 Domain of unknown function (DUF4318); Region: DUF4318; pfam14201 412694005934 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412694005935 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412694005936 hypothetical protein; Provisional; Region: PRK06753 412694005937 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 412694005938 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 412694005939 Virulence factor; Region: Virulence_fact; pfam13769 412694005940 HEAT repeats; Region: HEAT_2; pfam13646 412694005941 HEAT repeats; Region: HEAT_2; pfam13646 412694005942 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 412694005943 Protein of unknown function, DUF393; Region: DUF393; pfam04134 412694005944 Disulphide isomerase; Region: Disulph_isomer; pfam06491 412694005945 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 412694005946 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 412694005947 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 412694005948 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 412694005949 active site 412694005950 HIGH motif; other site 412694005951 KMSK motif region; other site 412694005952 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 412694005953 tRNA binding surface [nucleotide binding]; other site 412694005954 anticodon binding site; other site 412694005955 Methyltransferase domain; Region: Methyltransf_32; pfam13679 412694005956 Methyltransferase domain; Region: Methyltransf_31; pfam13847 412694005957 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694005958 S-adenosylmethionine binding site [chemical binding]; other site 412694005959 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 412694005960 putative catalytic site [active] 412694005961 putative metal binding site [ion binding]; other site 412694005962 putative phosphate binding site [ion binding]; other site 412694005963 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412694005964 binding surface 412694005965 TPR motif; other site 412694005966 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 412694005967 putative active site [active] 412694005968 TPR repeat; Region: TPR_11; pfam13414 412694005969 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412694005970 binding surface 412694005971 TPR motif; other site 412694005972 Tetratricopeptide repeat; Region: TPR_16; pfam13432 412694005973 TPR repeat; Region: TPR_11; pfam13414 412694005974 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412694005975 binding surface 412694005976 TPR motif; other site 412694005977 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412694005978 TPR motif; other site 412694005979 TPR repeat; Region: TPR_11; pfam13414 412694005980 binding surface 412694005981 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412694005982 binding surface 412694005983 TPR motif; other site 412694005984 Tetratricopeptide repeat; Region: TPR_12; pfam13424 412694005985 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412694005986 binding surface 412694005987 TPR motif; other site 412694005988 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 412694005989 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 412694005990 HIGH motif; other site 412694005991 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 412694005992 active site 412694005993 KMSKS motif; other site 412694005994 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 412694005995 tRNA binding surface [nucleotide binding]; other site 412694005996 anticodon binding site; other site 412694005997 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 412694005998 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 412694005999 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 412694006000 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 412694006001 Zn binding site [ion binding]; other site 412694006002 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 412694006003 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 412694006004 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 412694006005 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 412694006006 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 412694006007 Dimer interface [polypeptide binding]; other site 412694006008 anticodon binding site; other site 412694006009 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 412694006010 homodimer interface [polypeptide binding]; other site 412694006011 motif 1; other site 412694006012 motif 2; other site 412694006013 active site 412694006014 motif 3; other site 412694006015 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 412694006016 metal ion-dependent adhesion site (MIDAS); other site 412694006017 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 412694006018 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 412694006019 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412694006020 Walker A motif; other site 412694006021 ATP binding site [chemical binding]; other site 412694006022 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 412694006023 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 412694006024 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 412694006025 active site 412694006026 ATP binding site [chemical binding]; other site 412694006027 substrate binding site [chemical binding]; other site 412694006028 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412694006029 binding surface 412694006030 TPR motif; other site 412694006031 TPR repeat; Region: TPR_11; pfam13414 412694006032 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412694006033 binding surface 412694006034 TPR motif; other site 412694006035 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412694006036 binding surface 412694006037 Tetratricopeptide repeat; Region: TPR_12; pfam13424 412694006038 TPR motif; other site 412694006039 104 kDa microneme/rhoptry antigen; Provisional; Region: PTZ00449 412694006040 SseB protein; Region: SseB; cl06279 412694006041 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 412694006042 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 412694006043 Domain of unknown function (DUF4274); Region: DUF4274; pfam14096 412694006044 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 412694006045 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 412694006046 catalytic residues [active] 412694006047 catalytic nucleophile [active] 412694006048 Recombinase; Region: Recombinase; pfam07508 412694006049 Transposase; Region: DEDD_Tnp_IS110; pfam01548 412694006050 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 412694006051 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 412694006052 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 412694006053 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 412694006054 Protein of unknown function, DUF600; Region: DUF600; pfam04634 412694006055 The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424 412694006056 Immunity protein Imm3; Region: Imm3; pfam14425 412694006057 Domain of unknown function (DUF4274); Region: DUF4274; pfam14096 412694006058 glycerate kinase; Region: TIGR00045 412694006059 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 412694006060 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 412694006061 transmembrane helices; other site 412694006062 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412694006063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694006064 active site 412694006065 phosphorylation site [posttranslational modification] 412694006066 intermolecular recognition site; other site 412694006067 dimerization interface [polypeptide binding]; other site 412694006068 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412694006069 DNA binding site [nucleotide binding] 412694006070 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412694006071 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412694006072 dimerization interface [polypeptide binding]; other site 412694006073 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694006074 dimer interface [polypeptide binding]; other site 412694006075 phosphorylation site [posttranslational modification] 412694006076 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694006077 ATP binding site [chemical binding]; other site 412694006078 Mg2+ binding site [ion binding]; other site 412694006079 G-X-G motif; other site 412694006080 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 412694006081 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 412694006082 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 412694006083 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 412694006084 Na2 binding site [ion binding]; other site 412694006085 putative substrate binding site 1 [chemical binding]; other site 412694006086 Na binding site 1 [ion binding]; other site 412694006087 putative substrate binding site 2 [chemical binding]; other site 412694006088 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 412694006089 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 412694006090 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 412694006091 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 412694006092 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412694006093 motif II; other site 412694006094 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 412694006095 fructuronate transporter; Provisional; Region: PRK10034; cl15264 412694006096 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 412694006097 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 412694006098 active site 412694006099 NAD binding site [chemical binding]; other site 412694006100 metal binding site [ion binding]; metal-binding site 412694006101 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 412694006102 aspartate racemase; Region: asp_race; TIGR00035 412694006103 Escherichia coli YaeB and related proteins; Region: UPF0066; cl00749 412694006104 homodimer interaction site [polypeptide binding]; other site 412694006105 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 412694006106 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694006107 Coenzyme A binding pocket [chemical binding]; other site 412694006108 hypothetical protein; Validated; Region: PRK06769 412694006109 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412694006110 active site 412694006111 motif I; other site 412694006112 motif II; other site 412694006113 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 412694006114 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694006115 Coenzyme A binding pocket [chemical binding]; other site 412694006116 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 412694006117 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 412694006118 Walker A/P-loop; other site 412694006119 ATP binding site [chemical binding]; other site 412694006120 Q-loop/lid; other site 412694006121 ABC transporter signature motif; other site 412694006122 Walker B; other site 412694006123 D-loop; other site 412694006124 H-loop/switch region; other site 412694006125 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 412694006126 YpjP-like protein; Region: YpjP; pfam14005 412694006127 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 412694006128 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412694006129 motif II; other site 412694006130 hypothetical protein; Provisional; Region: PRK06724 412694006131 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 412694006132 active site 412694006133 metal binding site [ion binding]; metal-binding site 412694006134 Phosphotransferase enzyme family; Region: APH; pfam01636 412694006135 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 412694006136 active site 412694006137 ATP binding site [chemical binding]; other site 412694006138 substrate binding site [chemical binding]; other site 412694006139 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 412694006140 Active site serine [active] 412694006141 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 412694006142 Beta-lactamase; Region: Beta-lactamase; pfam00144 412694006143 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 412694006144 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 412694006145 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 412694006146 thymidylate synthase; Region: thym_sym; TIGR03284 412694006147 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 412694006148 dimerization interface [polypeptide binding]; other site 412694006149 active site 412694006150 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 412694006151 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 412694006152 folate binding site [chemical binding]; other site 412694006153 NADP+ binding site [chemical binding]; other site 412694006154 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 412694006155 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 412694006156 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 412694006157 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 412694006158 azoreductase; Reviewed; Region: PRK00170 412694006159 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 412694006160 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 412694006161 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 412694006162 putative acyl-acceptor binding pocket; other site 412694006163 Haemolysin-III related; Region: HlyIII; cl03831 412694006164 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 412694006165 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 412694006166 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 412694006167 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 412694006168 EDD domain protein, DegV family; Region: DegV; TIGR00762 412694006169 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 412694006170 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 412694006171 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 412694006172 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 412694006173 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 412694006174 Cu(I) binding site [ion binding]; other site 412694006175 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 412694006176 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 412694006177 putative dimer interface [polypeptide binding]; other site 412694006178 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 412694006179 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 412694006180 active site 412694006181 dimer interface [polypeptide binding]; other site 412694006182 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 412694006183 Ligand Binding Site [chemical binding]; other site 412694006184 Molecular Tunnel; other site 412694006185 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 412694006186 PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_3; cd03393 412694006187 active site 412694006188 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 412694006189 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 412694006190 siderophore binding site; other site 412694006191 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 412694006192 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 412694006193 homodimer interface [polypeptide binding]; other site 412694006194 substrate-cofactor binding pocket; other site 412694006195 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694006196 catalytic residue [active] 412694006197 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 412694006198 FMN binding site [chemical binding]; other site 412694006199 dimer interface [polypeptide binding]; other site 412694006200 Isochorismatase family; Region: Isochorismatase; pfam00857 412694006201 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 412694006202 catalytic triad [active] 412694006203 conserved cis-peptide bond; other site 412694006204 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 412694006205 nudix motif; other site 412694006206 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 412694006207 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 412694006208 putative dimer interface [polypeptide binding]; other site 412694006209 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 412694006210 Mechanosensitive ion channel; Region: MS_channel; pfam00924 412694006211 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 412694006212 GAF domain; Region: GAF; pfam01590 412694006213 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 412694006214 Histidine kinase; Region: HisKA_3; pfam07730 412694006215 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694006216 ATP binding site [chemical binding]; other site 412694006217 Mg2+ binding site [ion binding]; other site 412694006218 G-X-G motif; other site 412694006219 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 412694006220 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694006221 active site 412694006222 phosphorylation site [posttranslational modification] 412694006223 intermolecular recognition site; other site 412694006224 dimerization interface [polypeptide binding]; other site 412694006225 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 412694006226 DNA binding residues [nucleotide binding] 412694006227 dimerization interface [polypeptide binding]; other site 412694006228 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 412694006229 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 412694006230 putative active site [active] 412694006231 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 412694006232 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 412694006233 NAD binding site [chemical binding]; other site 412694006234 substrate binding site [chemical binding]; other site 412694006235 catalytic Zn binding site [ion binding]; other site 412694006236 tetramer interface [polypeptide binding]; other site 412694006237 structural Zn binding site [ion binding]; other site 412694006238 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 412694006239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694006240 dimer interface [polypeptide binding]; other site 412694006241 conserved gate region; other site 412694006242 ABC-ATPase subunit interface; other site 412694006243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694006244 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 412694006245 dimer interface [polypeptide binding]; other site 412694006246 conserved gate region; other site 412694006247 putative PBP binding loops; other site 412694006248 ABC-ATPase subunit interface; other site 412694006249 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 412694006250 Beta-lactamase; Region: Beta-lactamase; pfam00144 412694006251 Erythromycin esterase; Region: Erythro_esteras; pfam05139 412694006252 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 412694006253 fructuronate transporter; Provisional; Region: PRK10034; cl15264 412694006254 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 412694006255 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 412694006256 active site 412694006257 Predicted flavoprotein [General function prediction only]; Region: COG0431 412694006258 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 412694006259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694006260 H+ Antiporter protein; Region: 2A0121; TIGR00900 412694006261 putative substrate translocation pore; other site 412694006262 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 412694006263 Uncharacterized conserved protein [Function unknown]; Region: COG1434 412694006264 putative active site [active] 412694006265 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 412694006266 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 412694006267 Walker A/P-loop; other site 412694006268 ATP binding site [chemical binding]; other site 412694006269 Q-loop/lid; other site 412694006270 ABC transporter signature motif; other site 412694006271 Walker B; other site 412694006272 D-loop; other site 412694006273 H-loop/switch region; other site 412694006274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694006275 dimer interface [polypeptide binding]; other site 412694006276 conserved gate region; other site 412694006277 ABC-ATPase subunit interface; other site 412694006278 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 412694006279 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 412694006280 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 412694006281 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 412694006282 Protein of unknown function (DUF524); Region: DUF524; pfam04411 412694006283 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 412694006284 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 412694006285 DNA binding residues [nucleotide binding] 412694006286 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 412694006287 Domain of unknown function DUF21; Region: DUF21; pfam01595 412694006288 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 412694006289 Transporter associated domain; Region: CorC_HlyC; smart01091 412694006290 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 412694006291 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 412694006292 NAD(P) binding site [chemical binding]; other site 412694006293 catalytic residues [active] 412694006294 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 412694006295 Histidine kinase N terminal; Region: HisK_N; pfam09385 412694006296 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412694006297 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694006298 dimer interface [polypeptide binding]; other site 412694006299 phosphorylation site [posttranslational modification] 412694006300 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694006301 ATP binding site [chemical binding]; other site 412694006302 Mg2+ binding site [ion binding]; other site 412694006303 G-X-G motif; other site 412694006304 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 412694006305 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 412694006306 hypothetical protein; Provisional; Region: PRK06917 412694006307 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 412694006308 inhibitor-cofactor binding pocket; inhibition site 412694006309 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694006310 catalytic residue [active] 412694006311 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 412694006312 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 412694006313 acetylornithine deacetylase; Validated; Region: PRK06915 412694006314 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 412694006315 metal binding site [ion binding]; metal-binding site 412694006316 dimer interface [polypeptide binding]; other site 412694006317 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 412694006318 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 412694006319 PAS fold; Region: PAS_4; pfam08448 412694006320 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 412694006321 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412694006322 Walker A motif; other site 412694006323 ATP binding site [chemical binding]; other site 412694006324 Walker B motif; other site 412694006325 arginine finger; other site 412694006326 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 412694006327 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 412694006328 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412694006329 FeS/SAM binding site; other site 412694006330 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 412694006331 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 412694006332 toxin interface [polypeptide binding]; other site 412694006333 Zn binding site [ion binding]; other site 412694006334 Protein of unknown function (DUF3930); Region: DUF3930; pfam13067 412694006335 Protein of unknown function (DUF3930); Region: DUF3930; pfam13067 412694006336 YozD-like protein; Region: YozD; pfam14162 412694006337 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 412694006338 Catalytic domain of Protein Kinases; Region: PKc; cd00180 412694006339 active site 412694006340 ATP binding site [chemical binding]; other site 412694006341 substrate binding site [chemical binding]; other site 412694006342 activation loop (A-loop); other site 412694006343 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 412694006344 SpoOM protein; Region: Spo0M; pfam07070 412694006345 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 412694006346 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 412694006347 active site 412694006348 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 412694006349 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 412694006350 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 412694006351 catalytic residues [active] 412694006352 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 412694006353 homotrimer interaction site [polypeptide binding]; other site 412694006354 putative active site [active] 412694006355 CHRD domain; Region: CHRD; pfam07452 412694006356 C1q domain; Region: C1q; cl17543 412694006357 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 412694006358 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 412694006359 YolD-like protein; Region: YolD; pfam08863 412694006360 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 412694006361 classical (c) SDRs; Region: SDR_c; cd05233 412694006362 NAD(P) binding site [chemical binding]; other site 412694006363 active site 412694006364 Transglycosylase; Region: Transgly; pfam00912 412694006365 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 412694006366 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 412694006367 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694006368 Major Facilitator Superfamily; Region: MFS_1; pfam07690 412694006369 putative substrate translocation pore; other site 412694006370 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 412694006371 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 412694006372 dimer interface [polypeptide binding]; other site 412694006373 Citrate synthase; Region: Citrate_synt; pfam00285 412694006374 active site 412694006375 coenzyme A binding site [chemical binding]; other site 412694006376 citrylCoA binding site [chemical binding]; other site 412694006377 oxalacetate/citrate binding site [chemical binding]; other site 412694006378 catalytic triad [active] 412694006379 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 412694006380 2-methylcitrate dehydratase; Region: prpD; TIGR02330 412694006381 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 412694006382 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 412694006383 tetramer interface [polypeptide binding]; other site 412694006384 active site 412694006385 Mg2+/Mn2+ binding site [ion binding]; other site 412694006386 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 412694006387 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 412694006388 active site 412694006389 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 412694006390 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 412694006391 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 412694006392 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 412694006393 tetrameric interface [polypeptide binding]; other site 412694006394 NAD binding site [chemical binding]; other site 412694006395 catalytic residues [active] 412694006396 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 412694006397 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 412694006398 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 412694006399 substrate binding site [chemical binding]; other site 412694006400 oxyanion hole (OAH) forming residues; other site 412694006401 trimer interface [polypeptide binding]; other site 412694006402 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 412694006403 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 412694006404 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 412694006405 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 412694006406 active site 412694006407 metal binding site [ion binding]; metal-binding site 412694006408 DNA binding site [nucleotide binding] 412694006409 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 412694006410 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 412694006411 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 412694006412 Walker A/P-loop; other site 412694006413 ATP binding site [chemical binding]; other site 412694006414 Q-loop/lid; other site 412694006415 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 412694006416 ABC transporter signature motif; other site 412694006417 Walker B; other site 412694006418 D-loop; other site 412694006419 H-loop/switch region; other site 412694006420 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412694006421 dimerization interface [polypeptide binding]; other site 412694006422 putative DNA binding site [nucleotide binding]; other site 412694006423 putative Zn2+ binding site [ion binding]; other site 412694006424 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 412694006425 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 412694006426 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694006427 putative substrate translocation pore; other site 412694006428 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 412694006429 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 412694006430 putative NAD(P) binding site [chemical binding]; other site 412694006431 active site 412694006432 isochorismate synthase DhbC; Validated; Region: PRK06923 412694006433 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 412694006434 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 412694006435 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 412694006436 acyl-activating enzyme (AAE) consensus motif; other site 412694006437 active site 412694006438 AMP binding site [chemical binding]; other site 412694006439 substrate binding site [chemical binding]; other site 412694006440 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 412694006441 hydrophobic substrate binding pocket; other site 412694006442 Isochorismatase family; Region: Isochorismatase; pfam00857 412694006443 active site 412694006444 conserved cis-peptide bond; other site 412694006445 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 412694006446 Condensation domain; Region: Condensation; pfam00668 412694006447 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 412694006448 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 412694006449 acyl-activating enzyme (AAE) consensus motif; other site 412694006450 AMP binding site [chemical binding]; other site 412694006451 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 412694006452 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 412694006453 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 412694006454 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 412694006455 acyl-activating enzyme (AAE) consensus motif; other site 412694006456 AMP binding site [chemical binding]; other site 412694006457 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 412694006458 MbtH-like protein; Region: MbtH; cl01279 412694006459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694006460 Major Facilitator Superfamily; Region: MFS_1; pfam07690 412694006461 putative substrate translocation pore; other site 412694006462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694006463 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 412694006464 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 412694006465 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 412694006466 IHF dimer interface [polypeptide binding]; other site 412694006467 IHF - DNA interface [nucleotide binding]; other site 412694006468 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 412694006469 DinB family; Region: DinB; cl17821 412694006470 DinB superfamily; Region: DinB_2; pfam12867 412694006471 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 412694006472 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 412694006473 active site 412694006474 catalytic triad [active] 412694006475 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 412694006476 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 412694006477 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 412694006478 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 412694006479 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 412694006480 RNA binding surface [nucleotide binding]; other site 412694006481 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 412694006482 probable active site [active] 412694006483 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 412694006484 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 412694006485 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 412694006486 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 412694006487 active site 412694006488 dimer interface [polypeptide binding]; other site 412694006489 motif 1; other site 412694006490 motif 2; other site 412694006491 motif 3; other site 412694006492 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 412694006493 anticodon binding site; other site 412694006494 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 412694006495 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 412694006496 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 412694006497 Walker A/P-loop; other site 412694006498 ATP binding site [chemical binding]; other site 412694006499 Q-loop/lid; other site 412694006500 ABC transporter signature motif; other site 412694006501 Walker B; other site 412694006502 D-loop; other site 412694006503 H-loop/switch region; other site 412694006504 FtsX-like permease family; Region: FtsX; pfam02687 412694006505 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 412694006506 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 412694006507 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 412694006508 H+ Antiporter protein; Region: 2A0121; TIGR00900 412694006509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694006510 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 412694006511 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 412694006512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694006513 dimer interface [polypeptide binding]; other site 412694006514 conserved gate region; other site 412694006515 ABC-ATPase subunit interface; other site 412694006516 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 412694006517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694006518 S-adenosylmethionine binding site [chemical binding]; other site 412694006519 Protein of unknown function (DUF2185); Region: DUF2185; pfam09951 412694006520 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 412694006521 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 412694006522 active site 412694006523 Protein of unknown function (DUF2441); Region: DUF2441; pfam10386 412694006524 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 412694006525 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412694006526 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412694006527 MMPL family; Region: MMPL; pfam03176 412694006528 MMPL family; Region: MMPL; pfam03176 412694006529 Protein of unknown function (DUF4021); Region: DUF4021; pfam13213 412694006530 Chloramphenicol acetyltransferase; Region: CAT; cl02008 412694006531 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 412694006532 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694006533 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 412694006534 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 412694006535 Coenzyme A binding pocket [chemical binding]; other site 412694006536 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 412694006537 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694006538 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 412694006539 Coenzyme A binding pocket [chemical binding]; other site 412694006540 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 412694006541 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 412694006542 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 412694006543 putative acetyltransferase YhhY; Provisional; Region: PRK10140 412694006544 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694006545 Coenzyme A binding pocket [chemical binding]; other site 412694006546 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 412694006547 EamA-like transporter family; Region: EamA; pfam00892 412694006548 EamA-like transporter family; Region: EamA; pfam00892 412694006549 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 412694006550 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412694006551 non-specific DNA binding site [nucleotide binding]; other site 412694006552 salt bridge; other site 412694006553 sequence-specific DNA binding site [nucleotide binding]; other site 412694006554 Cupin domain; Region: Cupin_2; pfam07883 412694006555 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 412694006556 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 412694006557 protoporphyrinogen oxidase; Provisional; Region: PRK12416 412694006558 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 412694006559 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694006560 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 412694006561 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 412694006562 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 412694006563 DNA-binding site [nucleotide binding]; DNA binding site 412694006564 RNA-binding motif; other site 412694006565 CAAX protease self-immunity; Region: Abi; pfam02517 412694006566 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 412694006567 AAA domain; Region: AAA_18; pfam13238 412694006568 active site 412694006569 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 412694006570 active site 412694006571 metal binding site [ion binding]; metal-binding site 412694006572 hypothetical protein; Provisional; Region: PRK06770 412694006573 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412694006574 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412694006575 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 412694006576 dimerization interface [polypeptide binding]; other site 412694006577 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06728 412694006578 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 412694006579 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 412694006580 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 412694006581 active site 412694006582 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 412694006583 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 412694006584 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412694006585 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 412694006586 dimerization interface [polypeptide binding]; other site 412694006587 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 412694006588 MOSC domain; Region: MOSC; pfam03473 412694006589 3-alpha domain; Region: 3-alpha; pfam03475 412694006590 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694006591 Coenzyme A binding pocket [chemical binding]; other site 412694006592 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 412694006593 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 412694006594 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 412694006595 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412694006596 Walker A/P-loop; other site 412694006597 ATP binding site [chemical binding]; other site 412694006598 Q-loop/lid; other site 412694006599 ABC transporter signature motif; other site 412694006600 Walker B; other site 412694006601 D-loop; other site 412694006602 H-loop/switch region; other site 412694006603 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 412694006604 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 412694006605 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 412694006606 Walker A/P-loop; other site 412694006607 ATP binding site [chemical binding]; other site 412694006608 Q-loop/lid; other site 412694006609 ABC transporter signature motif; other site 412694006610 Walker B; other site 412694006611 D-loop; other site 412694006612 H-loop/switch region; other site 412694006613 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 412694006614 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 412694006615 active site 412694006616 metal binding site [ion binding]; metal-binding site 412694006617 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 412694006618 LysE type translocator; Region: LysE; cl00565 412694006619 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 412694006620 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412694006621 non-specific DNA binding site [nucleotide binding]; other site 412694006622 salt bridge; other site 412694006623 sequence-specific DNA binding site [nucleotide binding]; other site 412694006624 Cupin domain; Region: Cupin_2; pfam07883 412694006625 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 412694006626 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 412694006627 BclB C-terminal domain; Region: exospore_TM; TIGR03721 412694006628 Cupin; Region: Cupin_1; smart00835 412694006629 HD domain; Region: HD_4; pfam13328 412694006630 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 412694006631 metal binding triad [ion binding]; metal-binding site 412694006632 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 412694006633 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 412694006634 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 412694006635 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 412694006636 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412694006637 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 412694006638 Methyltransferase domain; Region: Methyltransf_31; pfam13847 412694006639 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694006640 S-adenosylmethionine binding site [chemical binding]; other site 412694006641 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 412694006642 Domain of unknown function (DUF3974); Region: DUF3974; pfam13120 412694006643 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 412694006644 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 412694006645 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 412694006646 active site 412694006647 P-loop; other site 412694006648 phosphorylation site [posttranslational modification] 412694006649 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 412694006650 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 412694006651 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 412694006652 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 412694006653 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 412694006654 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 412694006655 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 412694006656 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 412694006657 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412694006658 catalytic residue [active] 412694006659 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 412694006660 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 412694006661 tetramer interface [polypeptide binding]; other site 412694006662 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694006663 catalytic residue [active] 412694006664 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 412694006665 Proteins of 100 residues with WXG; Region: WXG100; cl02005 412694006666 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 412694006667 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 412694006668 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 412694006669 ATP binding site [chemical binding]; other site 412694006670 Mg++ binding site [ion binding]; other site 412694006671 motif III; other site 412694006672 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412694006673 nucleotide binding region [chemical binding]; other site 412694006674 ATP-binding site [chemical binding]; other site 412694006675 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412694006676 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412694006677 Predicted membrane-associated trancriptional regulator [Transcription]; Region: COG2512 412694006678 Helix-turn-helix domain; Region: HTH_36; pfam13730 412694006679 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 412694006680 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 412694006681 Phage integrase family; Region: Phage_integrase; pfam00589 412694006682 active site 412694006683 DNA binding site [nucleotide binding] 412694006684 Int/Topo IB signature motif; other site 412694006685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694006686 H+ Antiporter protein; Region: 2A0121; TIGR00900 412694006687 putative substrate translocation pore; other site 412694006688 FtsX-like permease family; Region: FtsX; pfam02687 412694006689 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 412694006690 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 412694006691 Walker A/P-loop; other site 412694006692 ATP binding site [chemical binding]; other site 412694006693 Q-loop/lid; other site 412694006694 ABC transporter signature motif; other site 412694006695 Walker B; other site 412694006696 D-loop; other site 412694006697 H-loop/switch region; other site 412694006698 Methyltransferase domain; Region: Methyltransf_23; pfam13489 412694006699 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694006700 S-adenosylmethionine binding site [chemical binding]; other site 412694006701 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 412694006702 dimer interface [polypeptide binding]; other site 412694006703 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 412694006704 dimer interface [polypeptide binding]; other site 412694006705 TPP-binding site [chemical binding]; other site 412694006706 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 412694006707 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 412694006708 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 412694006709 Int/Topo IB signature motif; other site 412694006710 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 412694006711 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 412694006712 C1q domain; Region: C1q; cl17543 412694006713 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 412694006714 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 412694006715 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 412694006716 Cytochrome P450; Region: p450; cl12078 412694006717 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 412694006718 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 412694006719 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 412694006720 MarR family; Region: MarR_2; pfam12802 412694006721 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 412694006722 catalytic core [active] 412694006723 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 412694006724 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 412694006725 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 412694006726 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 412694006727 metal binding site [ion binding]; metal-binding site 412694006728 dimer interface [polypeptide binding]; other site 412694006729 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 412694006730 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 412694006731 trimer interface [polypeptide binding]; other site 412694006732 active site 412694006733 substrate binding site [chemical binding]; other site 412694006734 CoA binding site [chemical binding]; other site 412694006735 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 412694006736 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 412694006737 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 412694006738 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 412694006739 active site 412694006740 catalytic triad [active] 412694006741 oxyanion hole [active] 412694006742 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 412694006743 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 412694006744 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 412694006745 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 412694006746 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 412694006747 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412694006748 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 412694006749 DNA binding residues [nucleotide binding] 412694006750 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 412694006751 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 412694006752 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 412694006753 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 412694006754 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 412694006755 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 412694006756 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 412694006757 beta-lactamase TEM; Provisional; Region: PRK15442 412694006758 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 412694006759 Transcriptional regulators [Transcription]; Region: PurR; COG1609 412694006760 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 412694006761 DNA binding site [nucleotide binding] 412694006762 domain linker motif; other site 412694006763 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 412694006764 dimerization interface [polypeptide binding]; other site 412694006765 ligand binding site [chemical binding]; other site 412694006766 polyol permease family; Region: 2A0118; TIGR00897 412694006767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694006768 putative substrate translocation pore; other site 412694006769 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 412694006770 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 412694006771 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 412694006772 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 412694006773 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 412694006774 substrate binding site [chemical binding]; other site 412694006775 ATP binding site [chemical binding]; other site 412694006776 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 412694006777 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 412694006778 tetrameric interface [polypeptide binding]; other site 412694006779 NAD binding site [chemical binding]; other site 412694006780 catalytic residues [active] 412694006781 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 412694006782 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 412694006783 PYR/PP interface [polypeptide binding]; other site 412694006784 dimer interface [polypeptide binding]; other site 412694006785 TPP binding site [chemical binding]; other site 412694006786 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 412694006787 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 412694006788 TPP-binding site; other site 412694006789 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 412694006790 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 412694006791 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 412694006792 intersubunit interface [polypeptide binding]; other site 412694006793 active site 412694006794 zinc binding site [ion binding]; other site 412694006795 Na+ binding site [ion binding]; other site 412694006796 KduI/IolB family; Region: KduI; pfam04962 412694006797 DinB superfamily; Region: DinB_2; pfam12867 412694006798 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 412694006799 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 412694006800 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 412694006801 active site 412694006802 metal binding site [ion binding]; metal-binding site 412694006803 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 412694006804 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412694006805 TPR motif; other site 412694006806 binding surface 412694006807 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412694006808 non-specific DNA binding site [nucleotide binding]; other site 412694006809 salt bridge; other site 412694006810 sequence-specific DNA binding site [nucleotide binding]; other site 412694006811 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 412694006812 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 412694006813 S-layer homology domain; Region: SLH; pfam00395 412694006814 S-layer homology domain; Region: SLH; pfam00395 412694006815 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 412694006816 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 412694006817 active site 412694006818 metal binding site [ion binding]; metal-binding site 412694006819 beta-channel forming cytolysin; Region: hlyII; TIGR01002 412694006820 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412694006821 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412694006822 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 412694006823 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 412694006824 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 412694006825 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 412694006826 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 412694006827 metal binding site [ion binding]; metal-binding site 412694006828 active site 412694006829 I-site; other site 412694006830 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 412694006831 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 412694006832 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 412694006833 Tar ligand binding domain homologue; Region: TarH; pfam02203 412694006834 Cache domain; Region: Cache_1; pfam02743 412694006835 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412694006836 dimerization interface [polypeptide binding]; other site 412694006837 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 412694006838 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 412694006839 dimer interface [polypeptide binding]; other site 412694006840 putative CheW interface [polypeptide binding]; other site 412694006841 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 412694006842 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 412694006843 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 412694006844 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 412694006845 active site residue [active] 412694006846 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 412694006847 active site residue [active] 412694006848 Protein of unknown function (DUF523); Region: DUF523; pfam04463 412694006849 Uncharacterized conserved protein [Function unknown]; Region: COG3272 412694006850 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 412694006851 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 412694006852 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 412694006853 FAD binding site [chemical binding]; other site 412694006854 homotetramer interface [polypeptide binding]; other site 412694006855 substrate binding pocket [chemical binding]; other site 412694006856 catalytic base [active] 412694006857 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 412694006858 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 412694006859 ATP-grasp domain; Region: ATP-grasp_4; cl17255 412694006860 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 412694006861 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 412694006862 carboxyltransferase (CT) interaction site; other site 412694006863 biotinylation site [posttranslational modification]; other site 412694006864 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 412694006865 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 412694006866 active site 412694006867 catalytic residues [active] 412694006868 metal binding site [ion binding]; metal-binding site 412694006869 enoyl-CoA hydratase; Provisional; Region: PRK07657 412694006870 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 412694006871 substrate binding site [chemical binding]; other site 412694006872 oxyanion hole (OAH) forming residues; other site 412694006873 trimer interface [polypeptide binding]; other site 412694006874 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 412694006875 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 412694006876 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 412694006877 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 412694006878 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 412694006879 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 412694006880 acyl-activating enzyme (AAE) consensus motif; other site 412694006881 putative AMP binding site [chemical binding]; other site 412694006882 putative active site [active] 412694006883 putative CoA binding site [chemical binding]; other site 412694006884 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 412694006885 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694006886 Coenzyme A binding pocket [chemical binding]; other site 412694006887 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 412694006888 hypothetical protein; Provisional; Region: PRK08233 412694006889 active site 412694006890 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 412694006891 DinB family; Region: DinB; cl17821 412694006892 DinB superfamily; Region: DinB_2; pfam12867 412694006893 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 412694006894 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 412694006895 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412694006896 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694006897 dimer interface [polypeptide binding]; other site 412694006898 phosphorylation site [posttranslational modification] 412694006899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694006900 ATP binding site [chemical binding]; other site 412694006901 Mg2+ binding site [ion binding]; other site 412694006902 G-X-G motif; other site 412694006903 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412694006904 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694006905 active site 412694006906 phosphorylation site [posttranslational modification] 412694006907 intermolecular recognition site; other site 412694006908 dimerization interface [polypeptide binding]; other site 412694006909 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412694006910 DNA binding site [nucleotide binding] 412694006911 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 412694006912 Zn2+ binding site [ion binding]; other site 412694006913 Mg2+ binding site [ion binding]; other site 412694006914 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 412694006915 S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06714 412694006916 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 412694006917 NADH(P)-binding; Region: NAD_binding_10; pfam13460 412694006918 NAD binding site [chemical binding]; other site 412694006919 substrate binding site [chemical binding]; other site 412694006920 putative active site [active] 412694006921 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694006922 Coenzyme A binding pocket [chemical binding]; other site 412694006923 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694006924 Coenzyme A binding pocket [chemical binding]; other site 412694006925 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 412694006926 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 412694006927 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 412694006928 active site 412694006929 Zn binding site [ion binding]; other site 412694006930 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 412694006931 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 412694006932 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 412694006933 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 412694006934 putative hydrophobic ligand binding site [chemical binding]; other site 412694006935 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412694006936 AAA domain; Region: AAA_21; pfam13304 412694006937 Walker A/P-loop; other site 412694006938 ATP binding site [chemical binding]; other site 412694006939 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412694006940 ABC transporter signature motif; other site 412694006941 Walker B; other site 412694006942 D-loop; other site 412694006943 H-loop/switch region; other site 412694006944 ATP-binding cassette domain of the excision repair protein UvrA; Region: ABC_UvrA; cd03238 412694006945 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 412694006946 Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354 412694006947 Predicted transcriptional regulators [Transcription]; Region: COG1695 412694006948 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 412694006949 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 412694006950 Beta-lactamase; Region: Beta-lactamase; pfam00144 412694006951 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 412694006952 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 412694006953 DNA binding residues [nucleotide binding] 412694006954 drug binding residues [chemical binding]; other site 412694006955 dimer interface [polypeptide binding]; other site 412694006956 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 412694006957 H+ Antiporter protein; Region: 2A0121; TIGR00900 412694006958 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694006959 putative substrate translocation pore; other site 412694006960 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 412694006961 nudix motif; other site 412694006962 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 412694006963 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 412694006964 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 412694006965 Phosphotransferase enzyme family; Region: APH; pfam01636 412694006966 active site 412694006967 ATP binding site [chemical binding]; other site 412694006968 substrate binding site [chemical binding]; other site 412694006969 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 412694006970 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412694006971 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 412694006972 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 412694006973 active site 412694006974 Zn binding site [ion binding]; other site 412694006975 Protein of unknown function (DUF4030); Region: DUF4030; pfam13222 412694006976 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 412694006977 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412694006978 DNA-binding site [nucleotide binding]; DNA binding site 412694006979 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412694006980 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694006981 homodimer interface [polypeptide binding]; other site 412694006982 catalytic residue [active] 412694006983 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694006984 S-adenosylmethionine binding site [chemical binding]; other site 412694006985 Methyltransferase domain; Region: Methyltransf_23; pfam13489 412694006986 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694006987 S-adenosylmethionine binding site [chemical binding]; other site 412694006988 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 412694006989 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 412694006990 catalytic core domain of class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674 412694006991 active site 412694006992 HIGH motif; other site 412694006993 KMSKS motif; other site 412694006994 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 412694006995 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 412694006996 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412694006997 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694006998 active site 412694006999 phosphorylation site [posttranslational modification] 412694007000 intermolecular recognition site; other site 412694007001 dimerization interface [polypeptide binding]; other site 412694007002 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412694007003 DNA binding site [nucleotide binding] 412694007004 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412694007005 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 412694007006 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694007007 ATP binding site [chemical binding]; other site 412694007008 Mg2+ binding site [ion binding]; other site 412694007009 G-X-G motif; other site 412694007010 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 412694007011 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 412694007012 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 412694007013 ABC transporter; Region: ABC_tran_2; pfam12848 412694007014 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 412694007015 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 412694007016 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 412694007017 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 412694007018 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 412694007019 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 412694007020 Walker A/P-loop; other site 412694007021 ATP binding site [chemical binding]; other site 412694007022 Q-loop/lid; other site 412694007023 ABC transporter signature motif; other site 412694007024 Walker B; other site 412694007025 D-loop; other site 412694007026 H-loop/switch region; other site 412694007027 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 412694007028 FtsX-like permease family; Region: FtsX; pfam02687 412694007029 hypothetical protein; Provisional; Region: PRK06760 412694007030 Protein of unknown function (DUF3914); Region: DUF3914; pfam13053 412694007031 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 412694007032 homoserine dehydrogenase; Validated; Region: PRK06813 412694007033 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 412694007034 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 412694007035 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412694007036 DNA-binding site [nucleotide binding]; DNA binding site 412694007037 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412694007038 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694007039 homodimer interface [polypeptide binding]; other site 412694007040 catalytic residue [active] 412694007041 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 412694007042 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 412694007043 ATP-grasp domain; Region: ATP-grasp_4; cl17255 412694007044 Putative transcription activator [Transcription]; Region: TenA; COG0819 412694007045 Protein of unknown function (DUF3962); Region: DUF3962; pfam13111 412694007046 Domain of unknown function (DUF3893); Region: DUF3893; pfam13032 412694007047 Protein of unknown function (DUF3959); Region: DUF3959; pfam13105 412694007048 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 412694007049 Protein of unknown function; Region: DUF3658; pfam12395 412694007050 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 412694007051 Cytochrome P450; Region: p450; cl12078 412694007052 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694007053 H+ Antiporter protein; Region: 2A0121; TIGR00900 412694007054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694007055 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 412694007056 trimer interface [polypeptide binding]; other site 412694007057 active site 412694007058 substrate binding site [chemical binding]; other site 412694007059 CoA binding site [chemical binding]; other site 412694007060 Predicted transcriptional regulators [Transcription]; Region: COG1695 412694007061 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 412694007062 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 412694007063 Cytochrome P450; Region: p450; cl12078 412694007064 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 412694007065 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412694007066 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 412694007067 active site 412694007068 motif I; other site 412694007069 motif II; other site 412694007070 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412694007071 PAS domain S-box; Region: sensory_box; TIGR00229 412694007072 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 412694007073 putative active site [active] 412694007074 heme pocket [chemical binding]; other site 412694007075 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 412694007076 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694007077 dimer interface [polypeptide binding]; other site 412694007078 phosphorylation site [posttranslational modification] 412694007079 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694007080 ATP binding site [chemical binding]; other site 412694007081 Mg2+ binding site [ion binding]; other site 412694007082 G-X-G motif; other site 412694007083 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 412694007084 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 412694007085 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 412694007086 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 412694007087 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 412694007088 glycosyltransferase, MGT family; Region: MGT; TIGR01426 412694007089 active site 412694007090 TDP-binding site; other site 412694007091 acceptor substrate-binding pocket; other site 412694007092 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 412694007093 aspartate racemase; Region: asp_race; TIGR00035 412694007094 hypothetical protein; Provisional; Region: PRK13661 412694007095 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13644 412694007096 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 412694007097 Walker A/P-loop; other site 412694007098 ATP binding site [chemical binding]; other site 412694007099 Q-loop/lid; other site 412694007100 ABC transporter signature motif; other site 412694007101 Walker B; other site 412694007102 D-loop; other site 412694007103 H-loop/switch region; other site 412694007104 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 412694007105 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 412694007106 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 412694007107 Walker A/P-loop; other site 412694007108 ATP binding site [chemical binding]; other site 412694007109 Q-loop/lid; other site 412694007110 ABC transporter signature motif; other site 412694007111 Walker B; other site 412694007112 D-loop; other site 412694007113 H-loop/switch region; other site 412694007114 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 412694007115 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 412694007116 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412694007117 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694007118 dimer interface [polypeptide binding]; other site 412694007119 phosphorylation site [posttranslational modification] 412694007120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694007121 ATP binding site [chemical binding]; other site 412694007122 Mg2+ binding site [ion binding]; other site 412694007123 G-X-G motif; other site 412694007124 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 412694007125 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 412694007126 active site 412694007127 ATP binding site [chemical binding]; other site 412694007128 substrate binding site [chemical binding]; other site 412694007129 activation loop (A-loop); other site 412694007130 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 412694007131 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 412694007132 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 412694007133 NAD(P) binding site [chemical binding]; other site 412694007134 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 412694007135 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 412694007136 active site 412694007137 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 412694007138 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 412694007139 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 412694007140 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 412694007141 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 412694007142 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412694007143 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412694007144 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 412694007145 classical (c) SDRs; Region: SDR_c; cd05233 412694007146 short chain dehydrogenase; Provisional; Region: PRK07832 412694007147 NAD(P) binding site [chemical binding]; other site 412694007148 active site 412694007149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694007150 putative substrate translocation pore; other site 412694007151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 412694007152 Beta-lactamase; Region: Beta-lactamase; pfam00144 412694007153 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 412694007154 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694007155 Coenzyme A binding pocket [chemical binding]; other site 412694007156 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 412694007157 EDD domain protein, DegV family; Region: DegV; TIGR00762 412694007158 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 412694007159 Putative amidotransferase; Region: DUF4066; pfam13278 412694007160 conserved cys residue [active] 412694007161 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 412694007162 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 412694007163 catalytic residues [active] 412694007164 Predicted transcriptional regulator [Transcription]; Region: COG2378 412694007165 HTH domain; Region: HTH_11; pfam08279 412694007166 WYL domain; Region: WYL; pfam13280 412694007167 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 412694007168 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 412694007169 conserved cys residue [active] 412694007170 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694007171 Coenzyme A binding pocket [chemical binding]; other site 412694007172 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg1; cd04777 412694007173 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 412694007174 DNA binding residues [nucleotide binding] 412694007175 putative dimer interface [polypeptide binding]; other site 412694007176 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 412694007177 H+ Antiporter protein; Region: 2A0121; TIGR00900 412694007178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694007179 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694007180 Coenzyme A binding pocket [chemical binding]; other site 412694007181 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 412694007182 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 412694007183 active site 412694007184 catalytic site [active] 412694007185 metal binding site [ion binding]; metal-binding site 412694007186 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 412694007187 active site 412694007188 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 412694007189 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 412694007190 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412694007191 DNA-binding site [nucleotide binding]; DNA binding site 412694007192 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412694007193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694007194 homodimer interface [polypeptide binding]; other site 412694007195 catalytic residue [active] 412694007196 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 412694007197 EamA-like transporter family; Region: EamA; pfam00892 412694007198 EamA-like transporter family; Region: EamA; pfam00892 412694007199 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 412694007200 Coenzyme A binding pocket [chemical binding]; other site 412694007201 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 412694007202 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 412694007203 Beta-lactamase; Region: Beta-lactamase; pfam00144 412694007204 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 412694007205 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 412694007206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694007207 putative substrate translocation pore; other site 412694007208 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 412694007209 nudix motif; other site 412694007210 DNA polymerase III subunit beta; Validated; Region: PRK06673 412694007211 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 412694007212 putative DNA binding surface [nucleotide binding]; other site 412694007213 dimer interface [polypeptide binding]; other site 412694007214 beta-clamp/clamp loader binding surface; other site 412694007215 beta-clamp/translesion DNA polymerase binding surface; other site 412694007216 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 412694007217 putative active site [active] 412694007218 nucleotide binding site [chemical binding]; other site 412694007219 nudix motif; other site 412694007220 putative metal binding site [ion binding]; other site 412694007221 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 412694007222 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 412694007223 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 412694007224 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 412694007225 catalytic core [active] 412694007226 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 412694007227 homotrimer interaction site [polypeptide binding]; other site 412694007228 putative active site [active] 412694007229 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 412694007230 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 412694007231 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 412694007232 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 412694007233 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 412694007234 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 412694007235 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 412694007236 active site 412694007237 nucleophile elbow; other site 412694007238 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 412694007239 pentamer interface [polypeptide binding]; other site 412694007240 dodecaamer interface [polypeptide binding]; other site 412694007241 metal-dependent hydrolase; Provisional; Region: PRK13291 412694007242 DinB superfamily; Region: DinB_2; pfam12867 412694007243 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 412694007244 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 412694007245 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 412694007246 Bacitracin resistance protein BacA; Region: BacA; pfam02673 412694007247 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 412694007248 GIY-YIG motif/motif A; other site 412694007249 active site 412694007250 catalytic site [active] 412694007251 putative DNA binding site [nucleotide binding]; other site 412694007252 metal binding site [ion binding]; metal-binding site 412694007253 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 412694007254 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694007255 Coenzyme A binding pocket [chemical binding]; other site 412694007256 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 412694007257 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 412694007258 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 412694007259 active site 412694007260 ATP binding site [chemical binding]; other site 412694007261 substrate binding site [chemical binding]; other site 412694007262 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 412694007263 nudix motif; other site 412694007264 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 412694007265 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 412694007266 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 412694007267 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 412694007268 MepB protein; Region: MepB; pfam08877 412694007269 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 412694007270 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 412694007271 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412694007272 motif II; other site 412694007273 DinB superfamily; Region: DinB_2; pfam12867 412694007274 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 412694007275 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 412694007276 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 412694007277 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 412694007278 active site 412694007279 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 412694007280 carbohydrate binding site [chemical binding]; other site 412694007281 pullulanase, type I; Region: pulA_typeI; TIGR02104 412694007282 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 412694007283 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 412694007284 Ca binding site [ion binding]; other site 412694007285 active site 412694007286 catalytic site [active] 412694007287 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 412694007288 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 412694007289 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 412694007290 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 412694007291 active site 412694007292 Zn binding site [ion binding]; other site 412694007293 Putative zinc-finger; Region: zf-HC2; pfam13490 412694007294 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 412694007295 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 412694007296 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412694007297 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 412694007298 DNA binding residues [nucleotide binding] 412694007299 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 412694007300 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 412694007301 active site 412694007302 metal binding site [ion binding]; metal-binding site 412694007303 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 412694007304 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 412694007305 SecY translocase; Region: SecY; pfam00344 412694007306 hypothetical protein; Validated; Region: PRK06672 412694007307 DnaA N-terminal domain; Region: DnaA_N; pfam11638 412694007308 DnaA N-terminal domain; Region: DnaA_N; pfam11638 412694007309 DnaA N-terminal domain; Region: DnaA_N; pfam11638 412694007310 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 412694007311 EamA-like transporter family; Region: EamA; pfam00892 412694007312 EamA-like transporter family; Region: EamA; pfam00892 412694007313 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 412694007314 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412694007315 DNA-binding site [nucleotide binding]; DNA binding site 412694007316 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412694007317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694007318 homodimer interface [polypeptide binding]; other site 412694007319 catalytic residue [active] 412694007320 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 412694007321 TAP-like protein; Region: Abhydrolase_4; pfam08386 412694007322 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 412694007323 Mg binding site [ion binding]; other site 412694007324 nucleotide binding site [chemical binding]; other site 412694007325 putative protofilament interface [polypeptide binding]; other site 412694007326 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 412694007327 Predicted membrane protein [Function unknown]; Region: COG4129 412694007328 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 412694007329 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 412694007330 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 412694007331 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 412694007332 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 412694007333 germination protein YpeB; Region: spore_YpeB; TIGR02889 412694007334 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 412694007335 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 412694007336 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 412694007337 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 412694007338 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 412694007339 Beta-lactamase; Region: Beta-lactamase; pfam00144 412694007340 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 412694007341 arylformamidase; Region: trp_arylform; TIGR03035 412694007342 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 412694007343 kynureninase; Region: kynureninase; TIGR01814 412694007344 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412694007345 catalytic residue [active] 412694007346 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412694007347 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412694007348 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 412694007349 nudix motif; other site 412694007350 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 412694007351 hydrophobic ligand binding site; other site 412694007352 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 412694007353 GAF domain; Region: GAF; pfam01590 412694007354 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412694007355 Walker A motif; other site 412694007356 ATP binding site [chemical binding]; other site 412694007357 Walker B motif; other site 412694007358 arginine finger; other site 412694007359 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 412694007360 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 412694007361 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694007362 Coenzyme A binding pocket [chemical binding]; other site 412694007363 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 412694007364 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 412694007365 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 412694007366 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694007367 S-adenosylmethionine binding site [chemical binding]; other site 412694007368 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 412694007369 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 412694007370 Rrf2 family protein; Region: rrf2_super; TIGR00738 412694007371 Transcriptional regulator; Region: Rrf2; pfam02082 412694007372 Protein of unknown function (DUF4085); Region: DUF4085; pfam13315 412694007373 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 412694007374 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 412694007375 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 412694007376 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 412694007377 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 412694007378 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 412694007379 E3 interaction surface; other site 412694007380 lipoyl attachment site [posttranslational modification]; other site 412694007381 e3 binding domain; Region: E3_binding; pfam02817 412694007382 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 412694007383 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 412694007384 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 412694007385 alpha subunit interface [polypeptide binding]; other site 412694007386 TPP binding site [chemical binding]; other site 412694007387 heterodimer interface [polypeptide binding]; other site 412694007388 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 412694007389 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 412694007390 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 412694007391 tetramer interface [polypeptide binding]; other site 412694007392 TPP-binding site [chemical binding]; other site 412694007393 heterodimer interface [polypeptide binding]; other site 412694007394 phosphorylation loop region [posttranslational modification] 412694007395 DinB superfamily; Region: DinB_2; pfam12867 412694007396 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 412694007397 short chain dehydrogenase; Provisional; Region: PRK06914 412694007398 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 412694007399 NADP binding site [chemical binding]; other site 412694007400 active site 412694007401 steroid binding site; other site 412694007402 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 412694007403 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 412694007404 AAA domain; Region: AAA_18; pfam13238 412694007405 active site 412694007406 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 412694007407 nudix motif; other site 412694007408 Protein phosphatase 2C; Region: PP2C_2; pfam13672 412694007409 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 412694007410 nucleotide binding site/active site [active] 412694007411 HIT family signature motif; other site 412694007412 catalytic residue [active] 412694007413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694007414 dimer interface [polypeptide binding]; other site 412694007415 conserved gate region; other site 412694007416 putative PBP binding loops; other site 412694007417 ABC-ATPase subunit interface; other site 412694007418 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 412694007419 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 412694007420 Walker A/P-loop; other site 412694007421 ATP binding site [chemical binding]; other site 412694007422 Q-loop/lid; other site 412694007423 ABC transporter signature motif; other site 412694007424 Walker B; other site 412694007425 D-loop; other site 412694007426 H-loop/switch region; other site 412694007427 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 412694007428 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 412694007429 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 412694007430 Clp protease; Region: CLP_protease; pfam00574 412694007431 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 412694007432 oligomer interface [polypeptide binding]; other site 412694007433 active site residues [active] 412694007434 RNA polymerase factor sigma-70; Validated; Region: PRK06704 412694007435 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412694007436 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 412694007437 DNA binding residues [nucleotide binding] 412694007438 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 412694007439 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 412694007440 catalytic loop [active] 412694007441 iron binding site [ion binding]; other site 412694007442 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 412694007443 tetramer (dimer of dimers) interface [polypeptide binding]; other site 412694007444 active site 412694007445 dimer interface [polypeptide binding]; other site 412694007446 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694007447 Coenzyme A binding pocket [chemical binding]; other site 412694007448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 412694007449 Chitin binding domain; Region: Chitin_bind_3; pfam03067 412694007450 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 412694007451 Interdomain contacts; other site 412694007452 Cytokine receptor motif; other site 412694007453 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 412694007454 Interdomain contacts; other site 412694007455 Cytokine receptor motif; other site 412694007456 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 412694007457 topology modulation protein; Reviewed; Region: PRK08118 412694007458 AAA domain; Region: AAA_17; pfam13207 412694007459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694007460 S-adenosylmethionine binding site [chemical binding]; other site 412694007461 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 412694007462 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694007463 Coenzyme A binding pocket [chemical binding]; other site 412694007464 S-layer homology domain; Region: SLH; pfam00395 412694007465 S-layer homology domain; Region: SLH; pfam00395 412694007466 S-layer homology domain; Region: SLH; pfam00395 412694007467 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 412694007468 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 412694007469 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 412694007470 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 412694007471 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 412694007472 active site 412694007473 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 412694007474 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694007475 Coenzyme A binding pocket [chemical binding]; other site 412694007476 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 412694007477 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 412694007478 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694007479 Coenzyme A binding pocket [chemical binding]; other site 412694007480 Protein of unknown function (DUF952); Region: DUF952; pfam06108 412694007481 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 412694007482 Part of AAA domain; Region: AAA_19; pfam13245 412694007483 Family description; Region: UvrD_C_2; pfam13538 412694007484 CAAX protease self-immunity; Region: Abi; pfam02517 412694007485 Methyltransferase domain; Region: Methyltransf_23; pfam13489 412694007486 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694007487 S-adenosylmethionine binding site [chemical binding]; other site 412694007488 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 412694007489 putative active site pocket [active] 412694007490 dimerization interface [polypeptide binding]; other site 412694007491 putative catalytic residue [active] 412694007492 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 412694007493 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 412694007494 ATP binding site [chemical binding]; other site 412694007495 putative Mg++ binding site [ion binding]; other site 412694007496 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412694007497 nucleotide binding region [chemical binding]; other site 412694007498 ATP-binding site [chemical binding]; other site 412694007499 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 412694007500 HRDC domain; Region: HRDC; pfam00570 412694007501 Protein of unknown function (DUF4017); Region: DUF4017; pfam13209 412694007502 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 412694007503 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 412694007504 active site 412694007505 Zn binding site [ion binding]; other site 412694007506 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 412694007507 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 412694007508 DHHA2 domain; Region: DHHA2; pfam02833 412694007509 Chitin binding domain; Region: Chitin_bind_3; pfam03067 412694007510 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 412694007511 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694007512 Coenzyme A binding pocket [chemical binding]; other site 412694007513 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 412694007514 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 412694007515 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 412694007516 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 412694007517 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 412694007518 NAD(P) binding site [chemical binding]; other site 412694007519 catalytic residues [active] 412694007520 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 412694007521 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 412694007522 inhibitor site; inhibition site 412694007523 active site 412694007524 dimer interface [polypeptide binding]; other site 412694007525 catalytic residue [active] 412694007526 Proline racemase; Region: Pro_racemase; pfam05544 412694007527 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 412694007528 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 412694007529 Proline racemase; Region: Pro_racemase; pfam05544 412694007530 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 412694007531 hydroxyglutarate oxidase; Provisional; Region: PRK11728 412694007532 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 412694007533 PAS domain; Region: PAS_10; pfam13596 412694007534 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 412694007535 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412694007536 Walker A motif; other site 412694007537 ATP binding site [chemical binding]; other site 412694007538 Walker B motif; other site 412694007539 arginine finger; other site 412694007540 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 412694007541 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 412694007542 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 412694007543 catalytic loop [active] 412694007544 iron binding site [ion binding]; other site 412694007545 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 412694007546 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 412694007547 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 412694007548 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 412694007549 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 412694007550 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 412694007551 DinB superfamily; Region: DinB_2; pfam12867 412694007552 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 412694007553 DltD N-terminal region; Region: DltD_N; pfam04915 412694007554 DltD central region; Region: DltD_M; pfam04918 412694007555 DltD C-terminal region; Region: DltD_C; pfam04914 412694007556 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 412694007557 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 412694007558 Coenzyme A binding pocket [chemical binding]; other site 412694007559 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 412694007560 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 412694007561 peptide binding site [polypeptide binding]; other site 412694007562 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 412694007563 NlpC/P60 family; Region: NLPC_P60; pfam00877 412694007564 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 412694007565 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 412694007566 active site 412694007567 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 412694007568 Septum formation initiator; Region: DivIC; pfam04977 412694007569 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 412694007570 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 412694007571 active site 412694007572 catalytic motif [active] 412694007573 Zn binding site [ion binding]; other site 412694007574 Methyltransferase domain; Region: Methyltransf_23; pfam13489 412694007575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694007576 S-adenosylmethionine binding site [chemical binding]; other site 412694007577 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 412694007578 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 412694007579 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412694007580 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412694007581 dimerization interface [polypeptide binding]; other site 412694007582 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694007583 dimer interface [polypeptide binding]; other site 412694007584 phosphorylation site [posttranslational modification] 412694007585 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694007586 ATP binding site [chemical binding]; other site 412694007587 Mg2+ binding site [ion binding]; other site 412694007588 G-X-G motif; other site 412694007589 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412694007590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694007591 active site 412694007592 phosphorylation site [posttranslational modification] 412694007593 intermolecular recognition site; other site 412694007594 dimerization interface [polypeptide binding]; other site 412694007595 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412694007596 DNA binding site [nucleotide binding] 412694007597 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 412694007598 bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Validated; Region: PRK06698 412694007599 bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Provisional; Region: PRK14697 412694007600 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412694007601 motif II; other site 412694007602 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 412694007603 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 412694007604 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 412694007605 Zn binding site [ion binding]; other site 412694007606 Spore germination protein; Region: Spore_permease; cl17796 412694007607 putative transporter; Provisional; Region: PRK11021 412694007608 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 412694007609 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412694007610 putative DNA binding site [nucleotide binding]; other site 412694007611 putative Zn2+ binding site [ion binding]; other site 412694007612 AsnC family; Region: AsnC_trans_reg; pfam01037 412694007613 EDD domain protein, DegV family; Region: DegV; TIGR00762 412694007614 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 412694007615 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 412694007616 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 412694007617 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 412694007618 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694007619 Coenzyme A binding pocket [chemical binding]; other site 412694007620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694007621 Major Facilitator Superfamily; Region: MFS_1; pfam07690 412694007622 putative substrate translocation pore; other site 412694007623 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694007624 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 412694007625 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 412694007626 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 412694007627 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 412694007628 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 412694007629 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 412694007630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694007631 Major Facilitator Superfamily; Region: MFS_1; pfam07690 412694007632 putative substrate translocation pore; other site 412694007633 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 412694007634 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 412694007635 active site 412694007636 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 412694007637 Methyltransferase domain; Region: Methyltransf_31; pfam13847 412694007638 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694007639 S-adenosylmethionine binding site [chemical binding]; other site 412694007640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694007641 putative substrate translocation pore; other site 412694007642 Major Facilitator Superfamily; Region: MFS_1; pfam07690 412694007643 aspartate aminotransferase; Provisional; Region: PRK07681 412694007644 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412694007645 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694007646 homodimer interface [polypeptide binding]; other site 412694007647 catalytic residue [active] 412694007648 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 412694007649 pantothenate kinase; Provisional; Region: PRK13317 412694007650 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 412694007651 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 412694007652 Protein of unknown function (DUF4052); Region: DUF4052; pfam13261 412694007653 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 412694007654 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 412694007655 Walker A/P-loop; other site 412694007656 ATP binding site [chemical binding]; other site 412694007657 Q-loop/lid; other site 412694007658 ABC transporter signature motif; other site 412694007659 Walker B; other site 412694007660 D-loop; other site 412694007661 H-loop/switch region; other site 412694007662 Predicted transcriptional regulators [Transcription]; Region: COG1725 412694007663 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412694007664 DNA-binding site [nucleotide binding]; DNA binding site 412694007665 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 412694007666 Domain of unknown function DUF20; Region: UPF0118; pfam01594 412694007667 HNH endonuclease; Region: HNH_5; pfam14279 412694007668 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 412694007669 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 412694007670 active site 412694007671 dimer interface [polypeptide binding]; other site 412694007672 non-prolyl cis peptide bond; other site 412694007673 insertion regions; other site 412694007674 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 412694007675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 412694007676 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 412694007677 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 412694007678 substrate binding pocket [chemical binding]; other site 412694007679 membrane-bound complex binding site; other site 412694007680 hinge residues; other site 412694007681 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 412694007682 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 412694007683 Walker A/P-loop; other site 412694007684 ATP binding site [chemical binding]; other site 412694007685 Q-loop/lid; other site 412694007686 ABC transporter signature motif; other site 412694007687 Walker B; other site 412694007688 D-loop; other site 412694007689 H-loop/switch region; other site 412694007690 Protein of unknown function (DUF402); Region: DUF402; pfam04167 412694007691 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 412694007692 nudix motif; other site 412694007693 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 412694007694 binding surface 412694007695 TPR motif; other site 412694007696 hypothetical protein; Provisional; Region: PRK09620 412694007697 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 412694007698 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 412694007699 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 412694007700 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 412694007701 Coenzyme A binding pocket [chemical binding]; other site 412694007702 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 412694007703 DinB superfamily; Region: DinB_2; pfam12867 412694007704 Protein of unknown function (DUF664); Region: DUF664; pfam04978 412694007705 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 412694007706 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694007707 Coenzyme A binding pocket [chemical binding]; other site 412694007708 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 412694007709 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 412694007710 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 412694007711 active site 412694007712 NTP binding site [chemical binding]; other site 412694007713 metal binding triad [ion binding]; metal-binding site 412694007714 antibiotic binding site [chemical binding]; other site 412694007715 A new structural DNA glycosylase; Region: AlkD_like; cd06561 412694007716 active site 412694007717 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 412694007718 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 412694007719 NodB motif; other site 412694007720 active site 412694007721 catalytic site [active] 412694007722 Zn binding site [ion binding]; other site 412694007723 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 412694007724 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 412694007725 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 412694007726 Sulfatase; Region: Sulfatase; pfam00884 412694007727 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 412694007728 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 412694007729 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 412694007730 ABC transporter; Region: ABC_tran_2; pfam12848 412694007731 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 412694007732 hypothetical protein; Provisional; Region: PRK06761 412694007733 MMPL family; Region: MMPL; pfam03176 412694007734 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 412694007735 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 412694007736 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412694007737 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412694007738 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 412694007739 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694007740 Coenzyme A binding pocket [chemical binding]; other site 412694007741 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 412694007742 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 412694007743 hinge; other site 412694007744 active site 412694007745 prephenate dehydrogenase; Validated; Region: PRK06545 412694007746 prephenate dehydrogenase; Validated; Region: PRK08507 412694007747 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 412694007748 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 412694007749 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412694007750 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694007751 homodimer interface [polypeptide binding]; other site 412694007752 catalytic residue [active] 412694007753 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 412694007754 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 412694007755 Tetramer interface [polypeptide binding]; other site 412694007756 active site 412694007757 FMN-binding site [chemical binding]; other site 412694007758 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 412694007759 Chorismate mutase type II; Region: CM_2; cl00693 412694007760 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 412694007761 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 412694007762 Domain of unknown function (DUF4020); Region: DUF4020; pfam13212 412694007763 Isochorismatase family; Region: Isochorismatase; pfam00857 412694007764 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 412694007765 catalytic triad [active] 412694007766 conserved cis-peptide bond; other site 412694007767 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 412694007768 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694007769 Coenzyme A binding pocket [chemical binding]; other site 412694007770 hypothetical protein; Provisional; Region: PRK06762 412694007771 AAA domain; Region: AAA_33; pfam13671 412694007772 Bacterial SH3 domain; Region: SH3_3; pfam08239 412694007773 Bacterial SH3 domain; Region: SH3_3; pfam08239 412694007774 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 412694007775 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 412694007776 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694007777 Coenzyme A binding pocket [chemical binding]; other site 412694007778 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 412694007779 enoyl-CoA hydratase; Provisional; Region: PRK06688 412694007780 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 412694007781 substrate binding site [chemical binding]; other site 412694007782 oxyanion hole (OAH) forming residues; other site 412694007783 trimer interface [polypeptide binding]; other site 412694007784 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 412694007785 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 412694007786 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 412694007787 putative AMP binding site [chemical binding]; other site 412694007788 putative active site [active] 412694007789 acyl-activating enzyme (AAE) consensus motif; other site 412694007790 putative CoA binding site [chemical binding]; other site 412694007791 PAS domain; Region: PAS; smart00091 412694007792 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 412694007793 putative active site [active] 412694007794 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412694007795 Walker A motif; other site 412694007796 ATP binding site [chemical binding]; other site 412694007797 Walker B motif; other site 412694007798 arginine finger; other site 412694007799 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 412694007800 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 412694007801 malate:quinone oxidoreductase; Validated; Region: PRK05257 412694007802 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 412694007803 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 412694007804 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 412694007805 ligand binding site [chemical binding]; other site 412694007806 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 412694007807 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 412694007808 TM-ABC transporter signature motif; other site 412694007809 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 412694007810 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 412694007811 TM-ABC transporter signature motif; other site 412694007812 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 412694007813 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 412694007814 Walker A/P-loop; other site 412694007815 ATP binding site [chemical binding]; other site 412694007816 Q-loop/lid; other site 412694007817 ABC transporter signature motif; other site 412694007818 Walker B; other site 412694007819 D-loop; other site 412694007820 H-loop/switch region; other site 412694007821 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 412694007822 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 412694007823 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 412694007824 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 412694007825 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 412694007826 putative N- and C-terminal domain interface [polypeptide binding]; other site 412694007827 putative active site [active] 412694007828 putative MgATP binding site [chemical binding]; other site 412694007829 catalytic site [active] 412694007830 metal binding site [ion binding]; metal-binding site 412694007831 putative carbohydrate binding site [chemical binding]; other site 412694007832 Cupin domain; Region: Cupin_2; pfam07883 412694007833 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 412694007834 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 412694007835 putative active site; other site 412694007836 catalytic residue [active] 412694007837 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 412694007838 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 412694007839 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 412694007840 active site 412694007841 NTP binding site [chemical binding]; other site 412694007842 metal binding triad [ion binding]; metal-binding site 412694007843 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 412694007844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694007845 H+ Antiporter protein; Region: 2A0121; TIGR00900 412694007846 putative substrate translocation pore; other site 412694007847 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412694007848 putative DNA binding site [nucleotide binding]; other site 412694007849 putative Zn2+ binding site [ion binding]; other site 412694007850 DinB superfamily; Region: DinB_2; pfam12867 412694007851 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 412694007852 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 412694007853 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 412694007854 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 412694007855 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 412694007856 putative catalytic cysteine [active] 412694007857 gamma-glutamyl kinase; Provisional; Region: PRK05429 412694007858 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 412694007859 nucleotide binding site [chemical binding]; other site 412694007860 homotetrameric interface [polypeptide binding]; other site 412694007861 putative phosphate binding site [ion binding]; other site 412694007862 putative allosteric binding site; other site 412694007863 PUA domain; Region: PUA; pfam01472 412694007864 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK12491 412694007865 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 412694007866 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 412694007867 putative metal binding site [ion binding]; other site 412694007868 putative dimer interface [polypeptide binding]; other site 412694007869 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 412694007870 Transcriptional regulator [Transcription]; Region: IclR; COG1414 412694007871 Bacterial transcriptional regulator; Region: IclR; pfam01614 412694007872 S-methylmethionine transporter; Provisional; Region: PRK11387 412694007873 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 412694007874 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 412694007875 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 412694007876 putative di-iron ligands [ion binding]; other site 412694007877 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 412694007878 dimer interface [polypeptide binding]; other site 412694007879 Alkaline phosphatase homologues; Region: alkPPc; smart00098 412694007880 active site 412694007881 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 412694007882 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412694007883 salt bridge; other site 412694007884 non-specific DNA binding site [nucleotide binding]; other site 412694007885 sequence-specific DNA binding site [nucleotide binding]; other site 412694007886 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 412694007887 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 412694007888 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 412694007889 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 412694007890 LytTr DNA-binding domain; Region: LytTR; pfam04397 412694007891 uridine kinase; Provisional; Region: PRK07667 412694007892 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 412694007893 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 412694007894 Coenzyme A binding pocket [chemical binding]; other site 412694007895 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 412694007896 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 412694007897 active site 412694007898 metal binding site [ion binding]; metal-binding site 412694007899 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 412694007900 MoxR-like ATPases [General function prediction only]; Region: COG0714 412694007901 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412694007902 Walker A motif; other site 412694007903 ATP binding site [chemical binding]; other site 412694007904 Walker B motif; other site 412694007905 arginine finger; other site 412694007906 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 412694007907 Protein of unknown function DUF58; Region: DUF58; pfam01882 412694007908 Domain of unknown function (DUF4018); Region: DUF4018; pfam13210 412694007909 proline/glycine betaine transporter; Provisional; Region: PRK10642 412694007910 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694007911 putative substrate translocation pore; other site 412694007912 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 412694007913 active site 412694007914 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 412694007915 active site 412694007916 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 412694007917 Ligand binding site; other site 412694007918 Putative Catalytic site; other site 412694007919 DXD motif; other site 412694007920 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 412694007921 active site 412694007922 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 412694007923 Ligand binding site; other site 412694007924 Putative Catalytic site; other site 412694007925 DXD motif; other site 412694007926 acetylornithine aminotransferase; Provisional; Region: PRK02627 412694007927 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 412694007928 inhibitor-cofactor binding pocket; inhibition site 412694007929 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694007930 catalytic residue [active] 412694007931 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 412694007932 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 412694007933 tetramer interface [polypeptide binding]; other site 412694007934 heme binding pocket [chemical binding]; other site 412694007935 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 412694007936 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 412694007937 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 412694007938 active site 412694007939 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 412694007940 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 412694007941 Beta-lactamase; Region: Beta-lactamase; pfam00144 412694007942 Protein of unknown function (DUF3902); Region: DUF3902; pfam13042 412694007943 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 412694007944 Uncharacterized conserved protein [Function unknown]; Region: COG1359 412694007945 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 412694007946 dimer interface [polypeptide binding]; other site 412694007947 FMN binding site [chemical binding]; other site 412694007948 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 412694007949 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412694007950 putative DNA binding site [nucleotide binding]; other site 412694007951 putative Zn2+ binding site [ion binding]; other site 412694007952 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 412694007953 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 412694007954 G1 box; other site 412694007955 putative GEF interaction site [polypeptide binding]; other site 412694007956 GTP/Mg2+ binding site [chemical binding]; other site 412694007957 Switch I region; other site 412694007958 G2 box; other site 412694007959 G3 box; other site 412694007960 Switch II region; other site 412694007961 G4 box; other site 412694007962 G5 box; other site 412694007963 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 412694007964 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 412694007965 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 412694007966 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 412694007967 nudix motif; other site 412694007968 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 412694007969 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 412694007970 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 412694007971 Walker A/P-loop; other site 412694007972 ATP binding site [chemical binding]; other site 412694007973 Q-loop/lid; other site 412694007974 ABC transporter signature motif; other site 412694007975 Walker B; other site 412694007976 D-loop; other site 412694007977 H-loop/switch region; other site 412694007978 Predicted transcriptional regulators [Transcription]; Region: COG1725 412694007979 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412694007980 DNA-binding site [nucleotide binding]; DNA binding site 412694007981 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 412694007982 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 412694007983 putative NAD(P) binding site [chemical binding]; other site 412694007984 active site 412694007985 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 412694007986 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 412694007987 Walker A/P-loop; other site 412694007988 ATP binding site [chemical binding]; other site 412694007989 Q-loop/lid; other site 412694007990 ABC transporter signature motif; other site 412694007991 Walker B; other site 412694007992 D-loop; other site 412694007993 H-loop/switch region; other site 412694007994 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 412694007995 FtsX-like permease family; Region: FtsX; pfam02687 412694007996 FtsX-like permease family; Region: FtsX; pfam02687 412694007997 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 412694007998 Beta-lactamase; Region: Beta-lactamase; pfam00144 412694007999 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 412694008000 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412694008001 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 412694008002 Domain of unknown function (DUF3980); Region: DUF3980; pfam13140 412694008003 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 412694008004 nudix motif; other site 412694008005 EamA-like transporter family; Region: EamA; pfam00892 412694008006 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 412694008007 EamA-like transporter family; Region: EamA; pfam00892 412694008008 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 412694008009 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412694008010 DNA-binding site [nucleotide binding]; DNA binding site 412694008011 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412694008012 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694008013 homodimer interface [polypeptide binding]; other site 412694008014 catalytic residue [active] 412694008015 hypothetical protein; Validated; Region: PRK00124 412694008016 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 412694008017 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 412694008018 uridine kinase; Validated; Region: PRK06696 412694008019 AAA domain; Region: AAA_18; pfam13238 412694008020 active site 412694008021 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 412694008022 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 412694008023 active site 412694008024 metal binding site [ion binding]; metal-binding site 412694008025 Phosphotransferase enzyme family; Region: APH; pfam01636 412694008026 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 412694008027 active site 412694008028 substrate binding site [chemical binding]; other site 412694008029 ATP binding site [chemical binding]; other site 412694008030 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 412694008031 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 412694008032 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 412694008033 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 412694008034 Coenzyme A binding pocket [chemical binding]; other site 412694008035 lysine transporter; Provisional; Region: PRK10836 412694008036 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 412694008037 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 412694008038 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 412694008039 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 412694008040 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 412694008041 putative active site [active] 412694008042 nucleotide binding site [chemical binding]; other site 412694008043 nudix motif; other site 412694008044 putative metal binding site [ion binding]; other site 412694008045 Cephalosporin hydroxylase; Region: CmcI; pfam04989 412694008046 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 412694008047 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 412694008048 Catalytic site [active] 412694008049 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 412694008050 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 412694008051 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 412694008052 NAD-dependent deacetylase; Provisional; Region: PRK00481 412694008053 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 412694008054 NAD+ binding site [chemical binding]; other site 412694008055 substrate binding site [chemical binding]; other site 412694008056 Zn binding site [ion binding]; other site 412694008057 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 412694008058 putative substrate binding pocket [chemical binding]; other site 412694008059 AC domain interface; other site 412694008060 catalytic triad [active] 412694008061 AB domain interface; other site 412694008062 interchain disulfide; other site 412694008063 Predicted membrane protein [Function unknown]; Region: COG3817 412694008064 Protein of unknown function (DUF979); Region: DUF979; pfam06166 412694008065 Protein of unknown function (DUF969); Region: DUF969; pfam06149 412694008066 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 412694008067 putative active site [active] 412694008068 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 412694008069 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 412694008070 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 412694008071 Transcriptional regulator [Transcription]; Region: IclR; COG1414 412694008072 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 412694008073 Bacterial transcriptional regulator; Region: IclR; pfam01614 412694008074 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 412694008075 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 412694008076 Catalytic site [active] 412694008077 CutC family; Region: CutC; cl01218 412694008078 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 412694008079 stage II sporulation protein P; Region: spore_II_P; TIGR02867 412694008080 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412694008081 dimerization interface [polypeptide binding]; other site 412694008082 putative DNA binding site [nucleotide binding]; other site 412694008083 putative Zn2+ binding site [ion binding]; other site 412694008084 DinB superfamily; Region: DinB_2; pfam12867 412694008085 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 412694008086 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 412694008087 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 412694008088 Uncharacterized conserved protein [Function unknown]; Region: COG1434 412694008089 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 412694008090 putative active site [active] 412694008091 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 412694008092 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 412694008093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 412694008094 Nucleoside recognition; Region: Gate; pfam07670 412694008095 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 412694008096 Phosphotransferase enzyme family; Region: APH; pfam01636 412694008097 putative active site [active] 412694008098 putative substrate binding site [chemical binding]; other site 412694008099 ATP binding site [chemical binding]; other site 412694008100 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694008101 Coenzyme A binding pocket [chemical binding]; other site 412694008102 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 412694008103 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 412694008104 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 412694008105 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412694008106 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412694008107 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 412694008108 phosphoenolpyruvate synthase; Validated; Region: PRK06241 412694008109 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 412694008110 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 412694008111 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 412694008112 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 412694008113 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 412694008114 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 412694008115 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 412694008116 LysE type translocator; Region: LysE; pfam01810 412694008117 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 412694008118 Spore germination protein; Region: Spore_permease; cl17796 412694008119 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 412694008120 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 412694008121 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 412694008122 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 412694008123 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 412694008124 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 412694008125 NAD binding site [chemical binding]; other site 412694008126 catalytic Zn binding site [ion binding]; other site 412694008127 structural Zn binding site [ion binding]; other site 412694008128 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 412694008129 dimanganese center [ion binding]; other site 412694008130 aspartate ammonia-lyase; Provisional; Region: PRK14515 412694008131 Aspartase; Region: Aspartase; cd01357 412694008132 active sites [active] 412694008133 tetramer interface [polypeptide binding]; other site 412694008134 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 412694008135 active site 412694008136 homodimer interface [polypeptide binding]; other site 412694008137 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 412694008138 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412694008139 non-specific DNA binding site [nucleotide binding]; other site 412694008140 sequence-specific DNA binding site [nucleotide binding]; other site 412694008141 salt bridge; other site 412694008142 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 412694008143 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 412694008144 Spore germination protein; Region: Spore_permease; pfam03845 412694008145 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 412694008146 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 412694008147 PAS domain S-box; Region: sensory_box; TIGR00229 412694008148 PAS domain S-box; Region: sensory_box; TIGR00229 412694008149 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 412694008150 putative active site [active] 412694008151 heme pocket [chemical binding]; other site 412694008152 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 412694008153 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 412694008154 putative active site [active] 412694008155 heme pocket [chemical binding]; other site 412694008156 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694008157 dimer interface [polypeptide binding]; other site 412694008158 phosphorylation site [posttranslational modification] 412694008159 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694008160 ATP binding site [chemical binding]; other site 412694008161 Mg2+ binding site [ion binding]; other site 412694008162 G-X-G motif; other site 412694008163 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 412694008164 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 412694008165 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 412694008166 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 412694008167 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 412694008168 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412694008169 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412694008170 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 412694008171 GIY-YIG motif/motif A; other site 412694008172 active site 412694008173 catalytic site [active] 412694008174 putative DNA binding site [nucleotide binding]; other site 412694008175 metal binding site [ion binding]; metal-binding site 412694008176 amino acid transporter; Region: 2A0306; TIGR00909 412694008177 Spore germination protein; Region: Spore_permease; cl17796 412694008178 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 412694008179 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK12491 412694008180 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 412694008181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694008182 Response regulator receiver domain; Region: Response_reg; pfam00072 412694008183 active site 412694008184 phosphorylation site [posttranslational modification] 412694008185 intermolecular recognition site; other site 412694008186 dimerization interface [polypeptide binding]; other site 412694008187 YcbB domain; Region: YcbB; pfam08664 412694008188 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412694008189 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694008190 ATP binding site [chemical binding]; other site 412694008191 G-X-G motif; other site 412694008192 glutaminase; Reviewed; Region: PRK12357 412694008193 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 412694008194 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 412694008195 amino acid carrier protein; Region: agcS; TIGR00835 412694008196 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 412694008197 transmembrane helices; other site 412694008198 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 412694008199 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 412694008200 active site 412694008201 active site 412694008202 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 412694008203 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 412694008204 putative active site [active] 412694008205 putative metal binding site [ion binding]; other site 412694008206 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 412694008207 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 412694008208 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 412694008209 Cl binding site [ion binding]; other site 412694008210 oligomer interface [polypeptide binding]; other site 412694008211 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 412694008212 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 412694008213 Mg binding site [ion binding]; other site 412694008214 nucleotide binding site [chemical binding]; other site 412694008215 putative protofilament interface [polypeptide binding]; other site 412694008216 Heat induced stress protein YflT; Region: YflT; pfam11181 412694008217 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 412694008218 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 412694008219 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 412694008220 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 412694008221 DNA photolyase; Region: DNA_photolyase; pfam00875 412694008222 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 412694008223 zinc binding site [ion binding]; other site 412694008224 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 412694008225 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 412694008226 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 412694008227 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 412694008228 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 412694008229 Protein of unknown function DUF58; Region: DUF58; pfam01882 412694008230 MoxR-like ATPases [General function prediction only]; Region: COG0714 412694008231 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412694008232 Walker A motif; other site 412694008233 ATP binding site [chemical binding]; other site 412694008234 Walker B motif; other site 412694008235 arginine finger; other site 412694008236 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 412694008237 UbiA prenyltransferase family; Region: UbiA; pfam01040 412694008238 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 412694008239 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 412694008240 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 412694008241 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 412694008242 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 412694008243 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 412694008244 Walker A/P-loop; other site 412694008245 ATP binding site [chemical binding]; other site 412694008246 Q-loop/lid; other site 412694008247 ABC transporter signature motif; other site 412694008248 Walker B; other site 412694008249 D-loop; other site 412694008250 H-loop/switch region; other site 412694008251 FtsX-like permease family; Region: FtsX; pfam02687 412694008252 FtsX-like permease family; Region: FtsX; pfam02687 412694008253 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 412694008254 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694008255 ATP binding site [chemical binding]; other site 412694008256 Mg2+ binding site [ion binding]; other site 412694008257 G-X-G motif; other site 412694008258 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 412694008259 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694008260 active site 412694008261 phosphorylation site [posttranslational modification] 412694008262 intermolecular recognition site; other site 412694008263 dimerization interface [polypeptide binding]; other site 412694008264 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 412694008265 DNA binding residues [nucleotide binding] 412694008266 dimerization interface [polypeptide binding]; other site 412694008267 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 412694008268 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 412694008269 metal binding site [ion binding]; metal-binding site 412694008270 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 412694008271 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 412694008272 ABC-ATPase subunit interface; other site 412694008273 dimer interface [polypeptide binding]; other site 412694008274 putative PBP binding regions; other site 412694008275 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 412694008276 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 412694008277 DJ-1 family protein; Region: not_thiJ; TIGR01383 412694008278 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 412694008279 conserved cys residue [active] 412694008280 Phosphotransferase enzyme family; Region: APH; pfam01636 412694008281 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 412694008282 active site 412694008283 ATP binding site [chemical binding]; other site 412694008284 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 412694008285 active site 412694008286 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 412694008287 Low molecular weight phosphatase family; Region: LMWPc; cd00115 412694008288 active site 412694008289 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 412694008290 arsenical-resistance protein; Region: acr3; TIGR00832 412694008291 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 412694008292 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 412694008293 putative metal binding site [ion binding]; other site 412694008294 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 412694008295 DnaJ domain; Region: DnaJ; pfam00226 412694008296 HSP70 interaction site [polypeptide binding]; other site 412694008297 TPR repeat; Region: TPR_11; pfam13414 412694008298 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412694008299 binding surface 412694008300 TPR motif; other site 412694008301 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 412694008302 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 412694008303 nucleotide binding site [chemical binding]; other site 412694008304 putative NEF/HSP70 interaction site [polypeptide binding]; other site 412694008305 SBD interface [polypeptide binding]; other site 412694008306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694008307 Major Facilitator Superfamily; Region: MFS_1; pfam07690 412694008308 putative substrate translocation pore; other site 412694008309 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 412694008310 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 412694008311 metal binding site [ion binding]; metal-binding site 412694008312 AAA domain; Region: AAA_11; pfam13086 412694008313 Part of AAA domain; Region: AAA_19; pfam13245 412694008314 Erp protein C-terminus; Region: Erp_C; pfam06780 412694008315 AAA domain; Region: AAA_30; pfam13604 412694008316 AAA domain; Region: AAA_12; pfam13087 412694008317 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 412694008318 putative active site [active] 412694008319 catalytic site [active] 412694008320 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 412694008321 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 412694008322 active site 412694008323 metal binding site [ion binding]; metal-binding site 412694008324 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 412694008325 putative monooxygenase; Provisional; Region: PRK11118 412694008326 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 412694008327 Cytochrome P450; Region: p450; pfam00067 412694008328 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 412694008329 Flavodoxin; Region: Flavodoxin_1; pfam00258 412694008330 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 412694008331 FAD binding pocket [chemical binding]; other site 412694008332 FAD binding motif [chemical binding]; other site 412694008333 catalytic residues [active] 412694008334 NAD binding pocket [chemical binding]; other site 412694008335 phosphate binding motif [ion binding]; other site 412694008336 beta-alpha-beta structure motif; other site 412694008337 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 412694008338 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694008339 putative substrate translocation pore; other site 412694008340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694008341 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 412694008342 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412694008343 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694008344 active site 412694008345 phosphorylation site [posttranslational modification] 412694008346 intermolecular recognition site; other site 412694008347 dimerization interface [polypeptide binding]; other site 412694008348 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412694008349 DNA binding site [nucleotide binding] 412694008350 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412694008351 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412694008352 dimerization interface [polypeptide binding]; other site 412694008353 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694008354 dimer interface [polypeptide binding]; other site 412694008355 phosphorylation site [posttranslational modification] 412694008356 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694008357 ATP binding site [chemical binding]; other site 412694008358 G-X-G motif; other site 412694008359 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 412694008360 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 412694008361 D-cysteine desulfhydrase; Validated; Region: PRK03910 412694008362 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 412694008363 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412694008364 catalytic residue [active] 412694008365 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 412694008366 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 412694008367 active site 412694008368 metal binding site [ion binding]; metal-binding site 412694008369 Domain of unknown function (DUF4073); Region: DUF4073; pfam13285 412694008370 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 412694008371 Beta-lactamase; Region: Beta-lactamase; pfam00144 412694008372 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 412694008373 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 412694008374 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 412694008375 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 412694008376 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412694008377 NAD(P) binding site [chemical binding]; other site 412694008378 active site 412694008379 hypothetical protein; Provisional; Region: PRK06849 412694008380 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412694008381 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 412694008382 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 412694008383 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 412694008384 dimer interface [polypeptide binding]; other site 412694008385 active site 412694008386 CoA binding pocket [chemical binding]; other site 412694008387 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 412694008388 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 412694008389 CAAX protease self-immunity; Region: Abi; pfam02517 412694008390 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 412694008391 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 412694008392 DNA binding residues [nucleotide binding] 412694008393 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 412694008394 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 412694008395 AAA domain; Region: AAA_33; pfam13671 412694008396 AAA domain; Region: AAA_17; pfam13207 412694008397 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 412694008398 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 412694008399 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 412694008400 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 412694008401 Walker A/P-loop; other site 412694008402 ATP binding site [chemical binding]; other site 412694008403 Q-loop/lid; other site 412694008404 ABC transporter signature motif; other site 412694008405 Walker B; other site 412694008406 D-loop; other site 412694008407 H-loop/switch region; other site 412694008408 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 412694008409 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 412694008410 FtsX-like permease family; Region: FtsX; pfam02687 412694008411 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412694008412 dimerization interface [polypeptide binding]; other site 412694008413 putative DNA binding site [nucleotide binding]; other site 412694008414 Predicted transcriptional regulator [Transcription]; Region: COG2345 412694008415 putative Zn2+ binding site [ion binding]; other site 412694008416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694008417 H+ Antiporter protein; Region: 2A0121; TIGR00900 412694008418 putative substrate translocation pore; other site 412694008419 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 412694008420 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412694008421 dimerization interface [polypeptide binding]; other site 412694008422 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694008423 dimer interface [polypeptide binding]; other site 412694008424 phosphorylation site [posttranslational modification] 412694008425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694008426 ATP binding site [chemical binding]; other site 412694008427 Mg2+ binding site [ion binding]; other site 412694008428 G-X-G motif; other site 412694008429 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412694008430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694008431 active site 412694008432 phosphorylation site [posttranslational modification] 412694008433 intermolecular recognition site; other site 412694008434 dimerization interface [polypeptide binding]; other site 412694008435 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412694008436 DNA binding site [nucleotide binding] 412694008437 Predicted membrane protein [Function unknown]; Region: COG2364 412694008438 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 412694008439 Transcriptional regulators [Transcription]; Region: MarR; COG1846 412694008440 MarR family; Region: MarR; pfam01047 412694008441 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 412694008442 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694008443 Coenzyme A binding pocket [chemical binding]; other site 412694008444 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 412694008445 Uncharacterized conserved protein [Function unknown]; Region: COG1284 412694008446 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 412694008447 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 412694008448 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 412694008449 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 412694008450 putative dimer interface [polypeptide binding]; other site 412694008451 catalytic triad [active] 412694008452 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 412694008453 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 412694008454 active site residue [active] 412694008455 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 412694008456 active site residue [active] 412694008457 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 412694008458 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 412694008459 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 412694008460 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 412694008461 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 412694008462 active site 412694008463 Zn binding site [ion binding]; other site 412694008464 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial homologs of mammalian glycerophosphodiester phosphodiesterase GDE4; Region: GDPD_GDE4_like_1; cd08613 412694008465 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 412694008466 putative active site [active] 412694008467 catalytic site [active] 412694008468 putative metal binding site [ion binding]; other site 412694008469 VanZ like family; Region: VanZ; pfam04892 412694008470 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412694008471 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694008472 dimer interface [polypeptide binding]; other site 412694008473 phosphorylation site [posttranslational modification] 412694008474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694008475 ATP binding site [chemical binding]; other site 412694008476 Mg2+ binding site [ion binding]; other site 412694008477 G-X-G motif; other site 412694008478 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412694008479 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694008480 active site 412694008481 phosphorylation site [posttranslational modification] 412694008482 intermolecular recognition site; other site 412694008483 dimerization interface [polypeptide binding]; other site 412694008484 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412694008485 DNA binding site [nucleotide binding] 412694008486 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 412694008487 Beta-lactamase; Region: Beta-lactamase; pfam00144 412694008488 S-layer homology domain; Region: SLH; pfam00395 412694008489 S-layer homology domain; Region: SLH; pfam00395 412694008490 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 412694008491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694008492 putative substrate translocation pore; other site 412694008493 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 412694008494 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 412694008495 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 412694008496 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412694008497 motif I; other site 412694008498 active site 412694008499 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 412694008500 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 412694008501 inhibitor-cofactor binding pocket; inhibition site 412694008502 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694008503 catalytic residue [active] 412694008504 Transcriptional regulators [Transcription]; Region: PurR; COG1609 412694008505 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 412694008506 DNA binding site [nucleotide binding] 412694008507 domain linker motif; other site 412694008508 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 412694008509 putative dimerization interface [polypeptide binding]; other site 412694008510 putative ligand binding site [chemical binding]; other site 412694008511 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 412694008512 TPR motif; other site 412694008513 Tetratricopeptide repeat; Region: TPR_12; pfam13424 412694008514 binding surface 412694008515 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412694008516 TPR motif; other site 412694008517 binding surface 412694008518 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cd00257 412694008519 PKC phosphorylation site [posttranslational modification]; other site 412694008520 DNA polymerase IV; Reviewed; Region: PRK03103 412694008521 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 412694008522 active site 412694008523 DNA binding site [nucleotide binding] 412694008524 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 412694008525 Tar ligand binding domain homologue; Region: TarH; pfam02203 412694008526 Cache domain; Region: Cache_1; pfam02743 412694008527 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412694008528 dimerization interface [polypeptide binding]; other site 412694008529 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 412694008530 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 412694008531 dimer interface [polypeptide binding]; other site 412694008532 putative CheW interface [polypeptide binding]; other site 412694008533 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 412694008534 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 412694008535 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 412694008536 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 412694008537 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 412694008538 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 412694008539 Fic/DOC family; Region: Fic; cl00960 412694008540 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 412694008541 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 412694008542 inhibitor-cofactor binding pocket; inhibition site 412694008543 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694008544 catalytic residue [active] 412694008545 Acylphosphatase; Region: Acylphosphatase; pfam00708 412694008546 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 412694008547 HypF finger; Region: zf-HYPF; pfam07503 412694008548 HypF finger; Region: zf-HYPF; pfam07503 412694008549 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 412694008550 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 412694008551 dimerization interface [polypeptide binding]; other site 412694008552 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 412694008553 ATP binding site [chemical binding]; other site 412694008554 Isochorismatase family; Region: Isochorismatase; pfam00857 412694008555 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 412694008556 catalytic triad [active] 412694008557 conserved cis-peptide bond; other site 412694008558 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 412694008559 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412694008560 putative DNA binding site [nucleotide binding]; other site 412694008561 putative Zn2+ binding site [ion binding]; other site 412694008562 AsnC family; Region: AsnC_trans_reg; pfam01037 412694008563 putative transporter; Provisional; Region: PRK11021 412694008564 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 412694008565 Uncharacterized conserved protein [Function unknown]; Region: COG4198 412694008566 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 412694008567 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 412694008568 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 412694008569 putative ligand binding site [chemical binding]; other site 412694008570 putative NAD binding site [chemical binding]; other site 412694008571 putative catalytic site [active] 412694008572 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 412694008573 L-serine binding site [chemical binding]; other site 412694008574 ACT domain interface; other site 412694008575 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 412694008576 homodimer interface [polypeptide binding]; other site 412694008577 substrate-cofactor binding pocket; other site 412694008578 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694008579 catalytic residue [active] 412694008580 Cupin domain; Region: Cupin_2; cl17218 412694008581 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 412694008582 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412694008583 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 412694008584 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 412694008585 Proteins of 100 residues with WXG; Region: WXG100; cl02005 412694008586 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 412694008587 Penicillin amidase; Region: Penicil_amidase; pfam01804 412694008588 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 412694008589 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 412694008590 active site 412694008591 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 412694008592 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 412694008593 amidase catalytic site [active] 412694008594 Zn binding residues [ion binding]; other site 412694008595 substrate binding site [chemical binding]; other site 412694008596 Bacterial SH3 domain; Region: SH3_3; pfam08239 412694008597 S-layer homology domain; Region: SLH; pfam00395 412694008598 S-layer homology domain; Region: SLH; pfam00395 412694008599 S-layer homology domain; Region: SLH; pfam00395 412694008600 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 412694008601 A new structural DNA glycosylase; Region: AlkD_like; cd06561 412694008602 active site 412694008603 Protein of unknown function (DUF3895); Region: DUF3895; pfam13034 412694008604 S-layer homology domain; Region: SLH; pfam00395 412694008605 S-layer homology domain; Region: SLH; pfam00395 412694008606 S-layer homology domain; Region: SLH; pfam00395 412694008607 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 412694008608 putative metal binding site [ion binding]; other site 412694008609 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 412694008610 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 412694008611 NETI protein; Region: NETI; pfam14044 412694008612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694008613 Major Facilitator Superfamily; Region: MFS_1; pfam07690 412694008614 putative substrate translocation pore; other site 412694008615 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 412694008616 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 412694008617 TAP-like protein; Region: Abhydrolase_4; pfam08386 412694008618 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 412694008619 MarR family; Region: MarR_2; pfam12802 412694008620 Major Facilitator Superfamily; Region: MFS_1; pfam07690 412694008621 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694008622 putative substrate translocation pore; other site 412694008623 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 412694008624 Beta-lactamase; Region: Beta-lactamase; pfam00144 412694008625 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 412694008626 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 412694008627 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 412694008628 Walker A/P-loop; other site 412694008629 ATP binding site [chemical binding]; other site 412694008630 Q-loop/lid; other site 412694008631 ABC transporter signature motif; other site 412694008632 Walker B; other site 412694008633 D-loop; other site 412694008634 H-loop/switch region; other site 412694008635 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412694008636 putative DNA binding site [nucleotide binding]; other site 412694008637 putative Zn2+ binding site [ion binding]; other site 412694008638 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 412694008639 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412694008640 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412694008641 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 412694008642 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 412694008643 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 412694008644 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 412694008645 SWIM zinc finger; Region: SWIM; pfam04434 412694008646 YwiC-like protein; Region: YwiC; pfam14256 412694008647 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 412694008648 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 412694008649 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 412694008650 Walker A/P-loop; other site 412694008651 ATP binding site [chemical binding]; other site 412694008652 Q-loop/lid; other site 412694008653 ABC transporter signature motif; other site 412694008654 Walker B; other site 412694008655 D-loop; other site 412694008656 H-loop/switch region; other site 412694008657 Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226 412694008658 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 412694008659 Walker A/P-loop; other site 412694008660 ATP binding site [chemical binding]; other site 412694008661 Q-loop/lid; other site 412694008662 ABC transporter signature motif; other site 412694008663 Walker B; other site 412694008664 D-loop; other site 412694008665 H-loop/switch region; other site 412694008666 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 412694008667 Calreticulin family; Region: Calreticulin; pfam00262 412694008668 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 412694008669 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 412694008670 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 412694008671 Predicted membrane protein [Function unknown]; Region: COG1288 412694008672 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 412694008673 Endonuclease I; Region: Endonuclease_1; pfam04231 412694008674 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 412694008675 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 412694008676 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 412694008677 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 412694008678 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 412694008679 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 412694008680 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 412694008681 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412694008682 non-specific DNA binding site [nucleotide binding]; other site 412694008683 salt bridge; other site 412694008684 sequence-specific DNA binding site [nucleotide binding]; other site 412694008685 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 412694008686 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 412694008687 metal binding site [ion binding]; metal-binding site 412694008688 YodA lipocalin-like domain; Region: YodA; pfam09223 412694008689 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 412694008690 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412694008691 DNA-binding site [nucleotide binding]; DNA binding site 412694008692 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412694008693 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694008694 homodimer interface [polypeptide binding]; other site 412694008695 catalytic residue [active] 412694008696 Proline dehydrogenase; Region: Pro_dh; cl03282 412694008697 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 412694008698 putative deacylase active site [active] 412694008699 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 412694008700 Beta-lactamase; Region: Beta-lactamase; pfam00144 412694008701 Beta-lactamase; Region: Beta-lactamase; pfam00144 412694008702 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 412694008703 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 412694008704 Histidine kinase; Region: HisKA_3; pfam07730 412694008705 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694008706 ATP binding site [chemical binding]; other site 412694008707 Mg2+ binding site [ion binding]; other site 412694008708 G-X-G motif; other site 412694008709 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 412694008710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694008711 active site 412694008712 phosphorylation site [posttranslational modification] 412694008713 intermolecular recognition site; other site 412694008714 dimerization interface [polypeptide binding]; other site 412694008715 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 412694008716 DNA binding residues [nucleotide binding] 412694008717 dimerization interface [polypeptide binding]; other site 412694008718 histidyl-tRNA synthetase; Provisional; Region: PRK12420 412694008719 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 412694008720 dimer interface [polypeptide binding]; other site 412694008721 motif 1; other site 412694008722 active site 412694008723 motif 2; other site 412694008724 motif 3; other site 412694008725 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 412694008726 anticodon binding site; other site 412694008727 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 412694008728 dimer interface [polypeptide binding]; other site 412694008729 FMN binding site [chemical binding]; other site 412694008730 pyruvate kinase; Validated; Region: PRK06739 412694008731 active site 412694008732 domain interfaces; other site 412694008733 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 412694008734 classical (c) SDRs; Region: SDR_c; cd05233 412694008735 NAD(P) binding site [chemical binding]; other site 412694008736 active site 412694008737 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 412694008738 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 412694008739 Walker A/P-loop; other site 412694008740 ATP binding site [chemical binding]; other site 412694008741 Q-loop/lid; other site 412694008742 ABC transporter signature motif; other site 412694008743 Walker B; other site 412694008744 D-loop; other site 412694008745 H-loop/switch region; other site 412694008746 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412694008747 non-specific DNA binding site [nucleotide binding]; other site 412694008748 salt bridge; other site 412694008749 sequence-specific DNA binding site [nucleotide binding]; other site 412694008750 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 412694008751 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412694008752 motif II; other site 412694008753 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 412694008754 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 412694008755 Probable transposase; Region: OrfB_IS605; pfam01385 412694008756 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 412694008757 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 412694008758 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 412694008759 catalytic residues [active] 412694008760 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 412694008761 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 412694008762 DNA binding residues [nucleotide binding] 412694008763 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 412694008764 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 412694008765 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 412694008766 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 412694008767 Coenzyme A binding pocket [chemical binding]; other site 412694008768 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 412694008769 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 412694008770 nudix motif; other site 412694008771 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 412694008772 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 412694008773 putative metal binding site [ion binding]; other site 412694008774 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 412694008775 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 412694008776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694008777 putative substrate translocation pore; other site 412694008778 Major Facilitator Superfamily; Region: MFS_1; pfam07690 412694008779 maltose O-acetyltransferase; Provisional; Region: PRK10092 412694008780 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 412694008781 active site 412694008782 substrate binding site [chemical binding]; other site 412694008783 trimer interface [polypeptide binding]; other site 412694008784 CoA binding site [chemical binding]; other site 412694008785 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 412694008786 Domain of unknown function DUF20; Region: UPF0118; pfam01594 412694008787 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694008788 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 412694008789 Coenzyme A binding pocket [chemical binding]; other site 412694008790 Methyltransferase domain; Region: Methyltransf_31; pfam13847 412694008791 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694008792 S-adenosylmethionine binding site [chemical binding]; other site 412694008793 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 412694008794 CGNR zinc finger; Region: zf-CGNR; pfam11706 412694008795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694008796 Major Facilitator Superfamily; Region: MFS_1; pfam07690 412694008797 putative substrate translocation pore; other site 412694008798 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412694008799 binding surface 412694008800 TPR motif; other site 412694008801 TPR repeat; Region: TPR_11; pfam13414 412694008802 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412694008803 binding surface 412694008804 Tetratricopeptide repeat; Region: TPR_16; pfam13432 412694008805 TPR motif; other site 412694008806 hypothetical protein; Provisional; Region: PRK04164 412694008807 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 412694008808 ATP synthase I chain; Region: ATP_synt_I; cl09170 412694008809 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 412694008810 Domain of unknown function DUF21; Region: DUF21; pfam01595 412694008811 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 412694008812 Transporter associated domain; Region: CorC_HlyC; smart01091 412694008813 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 412694008814 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 412694008815 DNA binding residues [nucleotide binding] 412694008816 putative dimer interface [polypeptide binding]; other site 412694008817 EamA-like transporter family; Region: EamA; pfam00892 412694008818 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 412694008819 EamA-like transporter family; Region: EamA; pfam00892 412694008820 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 412694008821 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 412694008822 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 412694008823 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 412694008824 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 412694008825 N- and C-terminal domain interface [polypeptide binding]; other site 412694008826 active site 412694008827 catalytic site [active] 412694008828 metal binding site [ion binding]; metal-binding site 412694008829 carbohydrate binding site [chemical binding]; other site 412694008830 ATP binding site [chemical binding]; other site 412694008831 GntP family permease; Region: GntP_permease; pfam02447 412694008832 fructuronate transporter; Provisional; Region: PRK10034; cl15264 412694008833 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 412694008834 active site 412694008835 intersubunit interactions; other site 412694008836 catalytic residue [active] 412694008837 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 412694008838 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 412694008839 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 412694008840 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 412694008841 TPP-binding site [chemical binding]; other site 412694008842 dimer interface [polypeptide binding]; other site 412694008843 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 412694008844 PYR/PP interface [polypeptide binding]; other site 412694008845 dimer interface [polypeptide binding]; other site 412694008846 TPP binding site [chemical binding]; other site 412694008847 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 412694008848 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 412694008849 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 412694008850 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 412694008851 hypothetical protein; Provisional; Region: PRK02487 412694008852 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 412694008853 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 412694008854 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 412694008855 IDEAL domain; Region: IDEAL; pfam08858 412694008856 Transcriptional regulator; Region: Rrf2; pfam02082 412694008857 Rrf2 family protein; Region: rrf2_super; TIGR00738 412694008858 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 412694008859 ArsC family; Region: ArsC; pfam03960 412694008860 putative catalytic residues [active] 412694008861 thiol/disulfide switch; other site 412694008862 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 412694008863 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412694008864 DNA-binding site [nucleotide binding]; DNA binding site 412694008865 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 412694008866 putative oxidoreductase; Provisional; Region: PRK10206 412694008867 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 412694008868 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 412694008869 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 412694008870 putative hydrophobic ligand binding site [chemical binding]; other site 412694008871 protein interface [polypeptide binding]; other site 412694008872 gate; other site 412694008873 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 412694008874 catalytic triad [active] 412694008875 oxyanion hole [active] 412694008876 active site 412694008877 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 412694008878 Phosphotransferase enzyme family; Region: APH; pfam01636 412694008879 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 412694008880 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 412694008881 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 412694008882 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 412694008883 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694008884 Coenzyme A binding pocket [chemical binding]; other site 412694008885 C factor cell-cell signaling protein; Provisional; Region: PRK09009 412694008886 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412694008887 NAD(P) binding site [chemical binding]; other site 412694008888 active site 412694008889 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 412694008890 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 412694008891 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 412694008892 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 412694008893 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 412694008894 AMP-binding enzyme; Region: AMP-binding; pfam00501 412694008895 acyl-activating enzyme (AAE) consensus motif; other site 412694008896 AMP binding site [chemical binding]; other site 412694008897 active site 412694008898 CoA binding site [chemical binding]; other site 412694008899 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 412694008900 CrcB-like protein; Region: CRCB; cl09114 412694008901 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 412694008902 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 412694008903 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 412694008904 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 412694008905 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 412694008906 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412694008907 dimerization interface [polypeptide binding]; other site 412694008908 putative DNA binding site [nucleotide binding]; other site 412694008909 putative Zn2+ binding site [ion binding]; other site 412694008910 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 412694008911 active site 412694008912 Glyco_18 domain; Region: Glyco_18; smart00636 412694008913 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 412694008914 Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962 412694008915 NodB motif; other site 412694008916 putative active site [active] 412694008917 putative catalytic site [active] 412694008918 putative Zn binding site [ion binding]; other site 412694008919 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 412694008920 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 412694008921 DXD motif; other site 412694008922 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 412694008923 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 412694008924 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412694008925 CAAX protease self-immunity; Region: Abi; pfam02517 412694008926 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412694008927 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412694008928 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 412694008929 Predicted transcriptional regulator [Transcription]; Region: COG2378 412694008930 HTH domain; Region: HTH_11; pfam08279 412694008931 WYL domain; Region: WYL; pfam13280 412694008932 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 412694008933 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 412694008934 ABC-2 type transporter; Region: ABC2_membrane; cl17235 412694008935 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 412694008936 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412694008937 Walker A/P-loop; other site 412694008938 ATP binding site [chemical binding]; other site 412694008939 Q-loop/lid; other site 412694008940 ABC transporter signature motif; other site 412694008941 Walker B; other site 412694008942 D-loop; other site 412694008943 H-loop/switch region; other site 412694008944 hydroxylamine reductase; Provisional; Region: PRK12310 412694008945 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 412694008946 ACS interaction site; other site 412694008947 CODH interaction site; other site 412694008948 metal cluster binding site [ion binding]; other site 412694008949 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 412694008950 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 412694008951 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 412694008952 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 412694008953 active site 412694008954 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 412694008955 metal binding site [ion binding]; metal-binding site 412694008956 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 412694008957 hypothetical protein; Provisional; Region: PRK06771 412694008958 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 412694008959 Beta-lactamase; Region: Beta-lactamase; pfam00144 412694008960 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 412694008961 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 412694008962 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 412694008963 dimer interface [polypeptide binding]; other site 412694008964 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 412694008965 ligand binding site [chemical binding]; other site 412694008966 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 412694008967 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 412694008968 ligand binding site [chemical binding]; other site 412694008969 flexible hinge region; other site 412694008970 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 412694008971 Protein of unknown function, DUF606; Region: DUF606; pfam04657 412694008972 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 412694008973 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 412694008974 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 412694008975 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 412694008976 Predicted transcriptional regulators [Transcription]; Region: COG1695 412694008977 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 412694008978 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 412694008979 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 412694008980 putative NAD(P) binding site [chemical binding]; other site 412694008981 dimer interface [polypeptide binding]; other site 412694008982 putative transport protein YifK; Provisional; Region: PRK10746 412694008983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694008984 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 412694008985 putative substrate translocation pore; other site 412694008986 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412694008987 NAD(P) binding site [chemical binding]; other site 412694008988 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412694008989 active site 412694008990 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 412694008991 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 412694008992 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 412694008993 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 412694008994 transmembrane helices; other site 412694008995 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 412694008996 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694008997 Coenzyme A binding pocket [chemical binding]; other site 412694008998 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 412694008999 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 412694009000 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 412694009001 putative ligand binding residues [chemical binding]; other site 412694009002 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 412694009003 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 412694009004 ABC-ATPase subunit interface; other site 412694009005 dimer interface [polypeptide binding]; other site 412694009006 putative PBP binding regions; other site 412694009007 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 412694009008 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 412694009009 ABC-ATPase subunit interface; other site 412694009010 dimer interface [polypeptide binding]; other site 412694009011 putative PBP binding regions; other site 412694009012 Protein of unknown function (DUF817); Region: DUF817; pfam05675 412694009013 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 412694009014 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 412694009015 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 412694009016 DinB superfamily; Region: DinB_2; pfam12867 412694009017 DinB family; Region: DinB; cl17821 412694009018 DinB superfamily; Region: DinB_2; pfam12867 412694009019 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412694009020 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412694009021 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 412694009022 dimerization interface [polypeptide binding]; other site 412694009023 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 412694009024 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 412694009025 NADP binding site [chemical binding]; other site 412694009026 dimer interface [polypeptide binding]; other site 412694009027 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 412694009028 catalytic core [active] 412694009029 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694009030 Coenzyme A binding pocket [chemical binding]; other site 412694009031 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 412694009032 MutS domain III; Region: MutS_III; pfam05192 412694009033 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412694009034 Walker A/P-loop; other site 412694009035 ATP binding site [chemical binding]; other site 412694009036 Q-loop/lid; other site 412694009037 ABC transporter signature motif; other site 412694009038 Walker B; other site 412694009039 D-loop; other site 412694009040 H-loop/switch region; other site 412694009041 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 412694009042 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 412694009043 active site 412694009044 Na/Ca binding site [ion binding]; other site 412694009045 catalytic site [active] 412694009046 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 412694009047 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 412694009048 oligoendopeptidase F; Region: pepF; TIGR00181 412694009049 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 412694009050 active site 412694009051 Zn binding site [ion binding]; other site 412694009052 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 412694009053 Beta-lactamase; Region: Beta-lactamase; pfam00144 412694009054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694009055 putative substrate translocation pore; other site 412694009056 Major Facilitator Superfamily; Region: MFS_1; pfam07690 412694009057 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412694009058 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412694009059 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 412694009060 putative dimerization interface [polypeptide binding]; other site 412694009061 Protein of unknown function (DUF3916); Region: DUF3916; pfam13079 412694009062 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 412694009063 putative active site [active] 412694009064 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 412694009065 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 412694009066 active site 412694009067 catalytic site [active] 412694009068 metal binding site [ion binding]; metal-binding site 412694009069 FAD binding domain; Region: FAD_binding_3; pfam01494 412694009070 hypothetical protein; Provisional; Region: PRK07236 412694009071 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412694009072 dimerization interface [polypeptide binding]; other site 412694009073 putative DNA binding site [nucleotide binding]; other site 412694009074 putative Zn2+ binding site [ion binding]; other site 412694009075 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 412694009076 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 412694009077 putative NAD(P) binding site [chemical binding]; other site 412694009078 Uncharacterized conserved protein [Function unknown]; Region: COG0397 412694009079 hypothetical protein; Validated; Region: PRK00029 412694009080 Tetratricopeptide repeat; Region: TPR_12; pfam13424 412694009081 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412694009082 TPR motif; other site 412694009083 binding surface 412694009084 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 412694009085 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 412694009086 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 412694009087 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 412694009088 Sodium Bile acid symporter family; Region: SBF; cl17470 412694009089 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 412694009090 FAD binding domain; Region: FAD_binding_4; pfam01565 412694009091 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 412694009092 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 412694009093 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 412694009094 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 412694009095 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 412694009096 trimer interface [polypeptide binding]; other site 412694009097 active site 412694009098 substrate binding site [chemical binding]; other site 412694009099 CoA binding site [chemical binding]; other site 412694009100 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 412694009101 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 412694009102 inhibitor-cofactor binding pocket; inhibition site 412694009103 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694009104 catalytic residue [active] 412694009105 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 412694009106 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 412694009107 active site 412694009108 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 412694009109 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 412694009110 active site 412694009111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694009112 Methyltransferase domain; Region: Methyltransf_23; pfam13489 412694009113 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 412694009114 enoyl-CoA hydratase; Provisional; Region: PRK06688 412694009115 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 412694009116 substrate binding site [chemical binding]; other site 412694009117 oxyanion hole (OAH) forming residues; other site 412694009118 trimer interface [polypeptide binding]; other site 412694009119 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 412694009120 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 412694009121 FOG: PKD repeat [General function prediction only]; Region: COG3291 412694009122 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 412694009123 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 412694009124 MgtC family; Region: MgtC; pfam02308 412694009125 Predicted acetyltransferase [General function prediction only]; Region: COG3981 412694009126 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 412694009127 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 412694009128 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 412694009129 putative metal binding site [ion binding]; other site 412694009130 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 412694009131 active site 412694009132 metal binding site [ion binding]; metal-binding site 412694009133 VanW like protein; Region: VanW; pfam04294 412694009134 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 412694009135 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 412694009136 exonuclease; Provisional; Region: PRK06722 412694009137 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 412694009138 active site 412694009139 catalytic site [active] 412694009140 substrate binding site [chemical binding]; other site 412694009141 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 412694009142 DNA-binding site [nucleotide binding]; DNA binding site 412694009143 RNA-binding motif; other site 412694009144 flavodoxin; Provisional; Region: PRK06703 412694009145 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 412694009146 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 412694009147 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 412694009148 trimer interface [polypeptide binding]; other site 412694009149 active site 412694009150 substrate binding site [chemical binding]; other site 412694009151 CoA binding site [chemical binding]; other site 412694009152 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694009153 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694009154 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694009155 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694009156 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694009157 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694009158 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694009159 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694009160 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694009161 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694009162 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694009163 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694009164 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694009165 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694009166 short chain dehydrogenase; Provisional; Region: PRK06924 412694009167 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 412694009168 NADP binding site [chemical binding]; other site 412694009169 homodimer interface [polypeptide binding]; other site 412694009170 active site 412694009171 Predicted acetyltransferase [General function prediction only]; Region: COG3393 412694009172 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 412694009173 argininosuccinate lyase; Provisional; Region: PRK06705 412694009174 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 412694009175 active sites [active] 412694009176 tetramer interface [polypeptide binding]; other site 412694009177 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 412694009178 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 412694009179 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 412694009180 active site 412694009181 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 412694009182 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 412694009183 Na binding site [ion binding]; other site 412694009184 Protein of unknown function (DUF997); Region: DUF997; pfam06196 412694009185 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 412694009186 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 412694009187 NAD(P) binding site [chemical binding]; other site 412694009188 catalytic residues [active] 412694009189 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 412694009190 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 412694009191 NAD(P) binding site [chemical binding]; other site 412694009192 homotetramer interface [polypeptide binding]; other site 412694009193 homodimer interface [polypeptide binding]; other site 412694009194 active site 412694009195 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 412694009196 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 412694009197 Divergent PAP2 family; Region: DUF212; pfam02681 412694009198 Predicted permeases [General function prediction only]; Region: RarD; COG2962 412694009199 antiporter inner membrane protein; Provisional; Region: PRK11670 412694009200 Domain of unknown function DUF59; Region: DUF59; pfam01883 412694009201 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 412694009202 Walker A motif; other site 412694009203 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 412694009204 MoaE homodimer interface [polypeptide binding]; other site 412694009205 MoaD interaction [polypeptide binding]; other site 412694009206 active site residues [active] 412694009207 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 412694009208 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 412694009209 dimer interface [polypeptide binding]; other site 412694009210 putative functional site; other site 412694009211 putative MPT binding site; other site 412694009212 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 412694009213 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 412694009214 ATP binding site [chemical binding]; other site 412694009215 substrate interface [chemical binding]; other site 412694009216 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 412694009217 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 412694009218 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412694009219 FeS/SAM binding site; other site 412694009220 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 412694009221 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 412694009222 Uncharacterized conserved protein [Function unknown]; Region: COG5609 412694009223 Uncharacterized conserved protein [Function unknown]; Region: COG2427 412694009224 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 412694009225 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 412694009226 catalytic loop [active] 412694009227 iron binding site [ion binding]; other site 412694009228 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 412694009229 4Fe-4S binding domain; Region: Fer4; pfam00037 412694009230 4Fe-4S binding domain; Region: Fer4; pfam00037 412694009231 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 412694009232 [4Fe-4S] binding site [ion binding]; other site 412694009233 molybdopterin cofactor binding site; other site 412694009234 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 412694009235 molybdopterin cofactor binding site; other site 412694009236 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 412694009237 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 412694009238 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 412694009239 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 412694009240 Tubulin like; Region: Tubulin_2; pfam13809 412694009241 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 412694009242 metal ion-dependent adhesion site (MIDAS); other site 412694009243 amidophosphoribosyltransferase; Provisional; Region: PRK09246 412694009244 Methyltransferase domain; Region: Methyltransf_31; pfam13847 412694009245 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694009246 S-adenosylmethionine binding site [chemical binding]; other site 412694009247 O-methyltransferase; Region: Methyltransf_2; pfam00891 412694009248 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 412694009249 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 412694009250 peptide binding site [polypeptide binding]; other site 412694009251 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 412694009252 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 412694009253 peptide binding site [polypeptide binding]; other site 412694009254 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 412694009255 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 412694009256 peptide binding site [polypeptide binding]; other site 412694009257 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 412694009258 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 412694009259 Transcriptional regulator [Transcription]; Region: LytR; COG1316 412694009260 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 412694009261 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412694009262 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 412694009263 DNA binding residues [nucleotide binding] 412694009264 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 412694009265 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 412694009266 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 412694009267 Walker A/P-loop; other site 412694009268 ATP binding site [chemical binding]; other site 412694009269 Q-loop/lid; other site 412694009270 ABC transporter signature motif; other site 412694009271 Walker B; other site 412694009272 D-loop; other site 412694009273 H-loop/switch region; other site 412694009274 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412694009275 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412694009276 putative oxidoreductase; Provisional; Region: PRK11579 412694009277 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 412694009278 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 412694009279 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 412694009280 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 412694009281 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 412694009282 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 412694009283 CAP-like domain; other site 412694009284 active site 412694009285 primary dimer interface [polypeptide binding]; other site 412694009286 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 412694009287 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 412694009288 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 412694009289 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 412694009290 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 412694009291 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694009292 ATP binding site [chemical binding]; other site 412694009293 Mg2+ binding site [ion binding]; other site 412694009294 G-X-G motif; other site 412694009295 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 412694009296 anchoring element; other site 412694009297 dimer interface [polypeptide binding]; other site 412694009298 ATP binding site [chemical binding]; other site 412694009299 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 412694009300 active site 412694009301 putative metal-binding site [ion binding]; other site 412694009302 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 412694009303 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 412694009304 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 412694009305 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 412694009306 protein binding site [polypeptide binding]; other site 412694009307 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412694009308 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694009309 active site 412694009310 phosphorylation site [posttranslational modification] 412694009311 intermolecular recognition site; other site 412694009312 dimerization interface [polypeptide binding]; other site 412694009313 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412694009314 DNA binding site [nucleotide binding] 412694009315 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 412694009316 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412694009317 FeS/SAM binding site; other site 412694009318 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 412694009319 Class III ribonucleotide reductase; Region: RNR_III; cd01675 412694009320 effector binding site; other site 412694009321 active site 412694009322 Zn binding site [ion binding]; other site 412694009323 glycine loop; other site 412694009324 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 412694009325 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 412694009326 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 412694009327 active site 412694009328 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 412694009329 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 412694009330 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 412694009331 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 412694009332 active site 412694009333 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 412694009334 DNA polymerase III subunit epsilon; Validated; Region: PRK06807 412694009335 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 412694009336 active site 412694009337 catalytic site [active] 412694009338 substrate binding site [chemical binding]; other site 412694009339 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 412694009340 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 412694009341 catalytic residues [active] 412694009342 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 412694009343 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 412694009344 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412694009345 Walker A/P-loop; other site 412694009346 ATP binding site [chemical binding]; other site 412694009347 Q-loop/lid; other site 412694009348 ABC transporter signature motif; other site 412694009349 Walker B; other site 412694009350 D-loop; other site 412694009351 H-loop/switch region; other site 412694009352 aconitate hydratase; Validated; Region: PRK09277 412694009353 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 412694009354 substrate binding site [chemical binding]; other site 412694009355 ligand binding site [chemical binding]; other site 412694009356 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 412694009357 substrate binding site [chemical binding]; other site 412694009358 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 412694009359 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 412694009360 NodB motif; other site 412694009361 active site 412694009362 catalytic site [active] 412694009363 metal binding site [ion binding]; metal-binding site 412694009364 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 412694009365 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 412694009366 putative dimer interface [polypeptide binding]; other site 412694009367 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 412694009368 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 412694009369 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 412694009370 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 412694009371 nudix motif; other site 412694009372 SAP domain; Region: SAP; pfam02037 412694009373 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 412694009374 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 412694009375 dimer interface [polypeptide binding]; other site 412694009376 active site 412694009377 acyl-CoA synthetase; Validated; Region: PRK07638 412694009378 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 412694009379 acyl-activating enzyme (AAE) consensus motif; other site 412694009380 AMP binding site [chemical binding]; other site 412694009381 active site 412694009382 CoA binding site [chemical binding]; other site 412694009383 BioY family; Region: BioY; pfam02632 412694009384 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 412694009385 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 412694009386 dimer interface [polypeptide binding]; other site 412694009387 acyl-activating enzyme (AAE) consensus motif; other site 412694009388 putative active site [active] 412694009389 AMP binding site [chemical binding]; other site 412694009390 putative CoA binding site [chemical binding]; other site 412694009391 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 412694009392 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412694009393 H-loop/switch region; other site 412694009394 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694009395 Coenzyme A binding pocket [chemical binding]; other site 412694009396 S-layer homology domain; Region: SLH; pfam00395 412694009397 S-layer homology domain; Region: SLH; pfam00395 412694009398 S-layer homology domain; Region: SLH; pfam00395 412694009399 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 412694009400 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 412694009401 amidase catalytic site [active] 412694009402 Zn binding residues [ion binding]; other site 412694009403 substrate binding site [chemical binding]; other site 412694009404 active site 412694009405 Protein phosphatase 2C; Region: PP2C_2; pfam13672 412694009406 Uncharacterized conserved protein [Function unknown]; Region: COG1284 412694009407 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 412694009408 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 412694009409 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 412694009410 dimer interface [polypeptide binding]; other site 412694009411 putative metal binding site [ion binding]; other site 412694009412 PAS domain S-box; Region: sensory_box; TIGR00229 412694009413 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 412694009414 putative active site [active] 412694009415 heme pocket [chemical binding]; other site 412694009416 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 412694009417 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 412694009418 putative active site [active] 412694009419 heme pocket [chemical binding]; other site 412694009420 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694009421 dimer interface [polypeptide binding]; other site 412694009422 phosphorylation site [posttranslational modification] 412694009423 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694009424 ATP binding site [chemical binding]; other site 412694009425 Mg2+ binding site [ion binding]; other site 412694009426 G-X-G motif; other site 412694009427 Predicted esterase [General function prediction only]; Region: COG0400 412694009428 putative hydrolase; Provisional; Region: PRK11460 412694009429 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 412694009430 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 412694009431 Zn binding site [ion binding]; other site 412694009432 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 412694009433 Zn binding site [ion binding]; other site 412694009434 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 412694009435 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 412694009436 Na binding site [ion binding]; other site 412694009437 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 412694009438 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 412694009439 active site 412694009440 FMN binding site [chemical binding]; other site 412694009441 substrate binding site [chemical binding]; other site 412694009442 3Fe-4S cluster binding site [ion binding]; other site 412694009443 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 412694009444 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 412694009445 FMN binding site [chemical binding]; other site 412694009446 active site 412694009447 substrate binding site [chemical binding]; other site 412694009448 catalytic residue [active] 412694009449 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 412694009450 agmatinase; Region: agmatinase; TIGR01230 412694009451 Agmatinase-like family; Region: Agmatinase-like; cd09990 412694009452 active site 412694009453 oligomer interface [polypeptide binding]; other site 412694009454 Mn binding site [ion binding]; other site 412694009455 imidazolonepropionase; Validated; Region: PRK09356 412694009456 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 412694009457 active site 412694009458 urocanate hydratase; Provisional; Region: PRK05414 412694009459 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 412694009460 active sites [active] 412694009461 tetramer interface [polypeptide binding]; other site 412694009462 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 412694009463 hexamer interface [polypeptide binding]; other site 412694009464 RNA binding site [nucleotide binding]; other site 412694009465 Histidine-zinc binding site [chemical binding]; other site 412694009466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694009467 S-adenosylmethionine binding site [chemical binding]; other site 412694009468 DJ-1 family protein; Region: not_thiJ; TIGR01383 412694009469 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 412694009470 conserved cys residue [active] 412694009471 AAA domain; Region: AAA_28; pfam13521 412694009472 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 412694009473 active site 412694009474 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 412694009475 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694009476 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694009477 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694009478 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694009479 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694009480 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694009481 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694009482 Domain of unknown function DUF11; Region: DUF11; cl17728 412694009483 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694009484 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694009485 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694009486 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694009487 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694009488 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694009489 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694009490 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694009491 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694009492 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694009493 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694009494 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 412694009495 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 412694009496 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 412694009497 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 412694009498 EamA-like transporter family; Region: EamA; pfam00892 412694009499 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 412694009500 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 412694009501 metal binding site [ion binding]; metal-binding site 412694009502 dimer interface [polypeptide binding]; other site 412694009503 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 412694009504 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 412694009505 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 412694009506 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412694009507 Walker A/P-loop; other site 412694009508 ATP binding site [chemical binding]; other site 412694009509 Q-loop/lid; other site 412694009510 ABC transporter signature motif; other site 412694009511 Walker B; other site 412694009512 D-loop; other site 412694009513 H-loop/switch region; other site 412694009514 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 412694009515 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412694009516 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 412694009517 putative dimerization interface [polypeptide binding]; other site 412694009518 putative substrate binding pocket [chemical binding]; other site 412694009519 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 412694009520 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 412694009521 nudix motif; other site 412694009522 Domain of unknown function (DUF3903); Region: DUF3903; pfam13043 412694009523 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 412694009524 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 412694009525 amidase catalytic site [active] 412694009526 Zn binding residues [ion binding]; other site 412694009527 substrate binding site [chemical binding]; other site 412694009528 S-layer homology domain; Region: SLH; pfam00395 412694009529 S-layer homology domain; Region: SLH; pfam00395 412694009530 S-layer homology domain; Region: SLH; pfam00395 412694009531 Nuclease-related domain; Region: NERD; pfam08378 412694009532 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 412694009533 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 412694009534 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 412694009535 Walker A/P-loop; other site 412694009536 ATP binding site [chemical binding]; other site 412694009537 Q-loop/lid; other site 412694009538 ABC transporter signature motif; other site 412694009539 Walker B; other site 412694009540 D-loop; other site 412694009541 H-loop/switch region; other site 412694009542 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 412694009543 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 412694009544 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412694009545 Walker A/P-loop; other site 412694009546 ATP binding site [chemical binding]; other site 412694009547 Q-loop/lid; other site 412694009548 ABC transporter signature motif; other site 412694009549 Walker B; other site 412694009550 D-loop; other site 412694009551 H-loop/switch region; other site 412694009552 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 412694009553 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 412694009554 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 412694009555 TPP-binding site [chemical binding]; other site 412694009556 dimer interface [polypeptide binding]; other site 412694009557 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 412694009558 PYR/PP interface [polypeptide binding]; other site 412694009559 dimer interface [polypeptide binding]; other site 412694009560 TPP binding site [chemical binding]; other site 412694009561 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 412694009562 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 412694009563 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694009564 dimer interface [polypeptide binding]; other site 412694009565 conserved gate region; other site 412694009566 ABC-ATPase subunit interface; other site 412694009567 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 412694009568 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694009569 dimer interface [polypeptide binding]; other site 412694009570 conserved gate region; other site 412694009571 ABC-ATPase subunit interface; other site 412694009572 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 412694009573 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 412694009574 Walker A/P-loop; other site 412694009575 ATP binding site [chemical binding]; other site 412694009576 Q-loop/lid; other site 412694009577 ABC transporter signature motif; other site 412694009578 Walker B; other site 412694009579 D-loop; other site 412694009580 H-loop/switch region; other site 412694009581 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 412694009582 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 412694009583 membrane-bound complex binding site; other site 412694009584 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 412694009585 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 412694009586 active site 412694009587 metal binding site [ion binding]; metal-binding site 412694009588 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 412694009589 hypothetical protein; Provisional; Region: PRK01546 412694009590 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 412694009591 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 412694009592 catalytic residues [active] 412694009593 catalytic nucleophile [active] 412694009594 LexA repressor; Validated; Region: PRK00215 412694009595 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412694009596 putative DNA binding site [nucleotide binding]; other site 412694009597 putative Zn2+ binding site [ion binding]; other site 412694009598 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 412694009599 Catalytic site [active] 412694009600 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 412694009601 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 412694009602 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 412694009603 glutamine synthetase, type I; Region: GlnA; TIGR00653 412694009604 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 412694009605 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 412694009606 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 412694009607 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 412694009608 DNA binding residues [nucleotide binding] 412694009609 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 412694009610 Aluminium resistance protein; Region: Alum_res; pfam06838 412694009611 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 412694009612 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 412694009613 HflX GTPase family; Region: HflX; cd01878 412694009614 G1 box; other site 412694009615 GTP/Mg2+ binding site [chemical binding]; other site 412694009616 Switch I region; other site 412694009617 G2 box; other site 412694009618 G3 box; other site 412694009619 Switch II region; other site 412694009620 G4 box; other site 412694009621 G5 box; other site 412694009622 Predicted membrane protein [Function unknown]; Region: COG2860 412694009623 UPF0126 domain; Region: UPF0126; pfam03458 412694009624 UPF0126 domain; Region: UPF0126; pfam03458 412694009625 stage V sporulation protein K; Region: spore_V_K; TIGR02881 412694009626 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412694009627 Walker A motif; other site 412694009628 ATP binding site [chemical binding]; other site 412694009629 Walker B motif; other site 412694009630 arginine finger; other site 412694009631 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 412694009632 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 412694009633 active site 412694009634 catalytic residues [active] 412694009635 DNA binding site [nucleotide binding] 412694009636 Int/Topo IB signature motif; other site 412694009637 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 412694009638 bacterial Hfq-like; Region: Hfq; cd01716 412694009639 hexamer interface [polypeptide binding]; other site 412694009640 Sm1 motif; other site 412694009641 RNA binding site [nucleotide binding]; other site 412694009642 Sm2 motif; other site 412694009643 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 412694009644 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 412694009645 Bacterial SH3 domain; Region: SH3_3; pfam08239 412694009646 Bacterial SH3 domain; Region: SH3_3; pfam08239 412694009647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 412694009648 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 412694009649 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 412694009650 active site 412694009651 phosphorylation site [posttranslational modification] 412694009652 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 412694009653 active site 412694009654 P-loop; other site 412694009655 phosphorylation site [posttranslational modification] 412694009656 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 412694009657 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 412694009658 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 412694009659 putative substrate binding site [chemical binding]; other site 412694009660 putative ATP binding site [chemical binding]; other site 412694009661 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 412694009662 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 412694009663 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 412694009664 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 412694009665 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 412694009666 dimer interface [polypeptide binding]; other site 412694009667 active site 412694009668 metal binding site [ion binding]; metal-binding site 412694009669 Predicted membrane protein [Function unknown]; Region: COG2322 412694009670 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 412694009671 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 412694009672 Glyco_18 domain; Region: Glyco_18; smart00636 412694009673 putative active site [active] 412694009674 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 412694009675 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 412694009676 putative active site [active] 412694009677 putative metal binding site [ion binding]; other site 412694009678 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 412694009679 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 412694009680 IHF dimer interface [polypeptide binding]; other site 412694009681 IHF - DNA interface [nucleotide binding]; other site 412694009682 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 412694009683 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 412694009684 metal-binding site [ion binding] 412694009685 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 412694009686 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 412694009687 metal-binding site [ion binding] 412694009688 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 412694009689 Soluble P-type ATPase [General function prediction only]; Region: COG4087 412694009690 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 412694009691 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 412694009692 metal-binding site [ion binding] 412694009693 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 412694009694 putative homodimer interface [polypeptide binding]; other site 412694009695 putative homotetramer interface [polypeptide binding]; other site 412694009696 putative allosteric switch controlling residues; other site 412694009697 putative metal binding site [ion binding]; other site 412694009698 putative homodimer-homodimer interface [polypeptide binding]; other site 412694009699 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 412694009700 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 412694009701 DNA binding residues [nucleotide binding] 412694009702 dimerization interface [polypeptide binding]; other site 412694009703 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 412694009704 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 412694009705 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 412694009706 Walker A/P-loop; other site 412694009707 ATP binding site [chemical binding]; other site 412694009708 Q-loop/lid; other site 412694009709 ABC transporter signature motif; other site 412694009710 Walker B; other site 412694009711 D-loop; other site 412694009712 H-loop/switch region; other site 412694009713 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 412694009714 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 412694009715 ABC-ATPase subunit interface; other site 412694009716 dimer interface [polypeptide binding]; other site 412694009717 putative PBP binding regions; other site 412694009718 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 412694009719 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 412694009720 ABC-ATPase subunit interface; other site 412694009721 dimer interface [polypeptide binding]; other site 412694009722 putative PBP binding regions; other site 412694009723 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 412694009724 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 412694009725 putative ligand binding residues [chemical binding]; other site 412694009726 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 412694009727 active site 412694009728 putative catalytic site [active] 412694009729 DNA binding site [nucleotide binding] 412694009730 putative phosphate binding site [ion binding]; other site 412694009731 metal binding site A [ion binding]; metal-binding site 412694009732 AP binding site [nucleotide binding]; other site 412694009733 metal binding site B [ion binding]; metal-binding site 412694009734 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 412694009735 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 412694009736 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412694009737 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412694009738 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 412694009739 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 412694009740 DNA binding site [nucleotide binding] 412694009741 active site 412694009742 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 412694009743 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 412694009744 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 412694009745 minor groove reading motif; other site 412694009746 helix-hairpin-helix signature motif; other site 412694009747 substrate binding pocket [chemical binding]; other site 412694009748 active site 412694009749 peptidase T; Region: peptidase-T; TIGR01882 412694009750 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 412694009751 metal binding site [ion binding]; metal-binding site 412694009752 dimer interface [polypeptide binding]; other site 412694009753 Predicted membrane protein [Function unknown]; Region: COG2364 412694009754 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 412694009755 hypothetical protein; Provisional; Region: PRK06764 412694009756 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 412694009757 catalytic core [active] 412694009758 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 412694009759 PAS domain S-box; Region: sensory_box; TIGR00229 412694009760 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 412694009761 putative active site [active] 412694009762 heme pocket [chemical binding]; other site 412694009763 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 412694009764 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 412694009765 metal binding site [ion binding]; metal-binding site 412694009766 active site 412694009767 I-site; other site 412694009768 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 412694009769 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 412694009770 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 412694009771 active site 412694009772 homodimer interface [polypeptide binding]; other site 412694009773 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412694009774 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 412694009775 NAD(P) binding site [chemical binding]; other site 412694009776 active site 412694009777 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 412694009778 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 412694009779 NAD(P) binding site [chemical binding]; other site 412694009780 homodimer interface [polypeptide binding]; other site 412694009781 substrate binding site [chemical binding]; other site 412694009782 active site 412694009783 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 412694009784 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 412694009785 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412694009786 active site 412694009787 motif I; other site 412694009788 motif II; other site 412694009789 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 412694009790 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 412694009791 ligand binding site [chemical binding]; other site 412694009792 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 412694009793 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 412694009794 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 412694009795 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412694009796 DNA-binding site [nucleotide binding]; DNA binding site 412694009797 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412694009798 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694009799 homodimer interface [polypeptide binding]; other site 412694009800 catalytic residue [active] 412694009801 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 412694009802 active site 412694009803 catalytic site [active] 412694009804 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 412694009805 putative active site [active] 412694009806 putative catalytic triad [active] 412694009807 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 412694009808 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 412694009809 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 412694009810 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 412694009811 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 412694009812 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 412694009813 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 412694009814 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 412694009815 Sulfatase; Region: Sulfatase; pfam00884 412694009816 Tetratricopeptide repeat; Region: TPR_16; pfam13432 412694009817 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412694009818 binding surface 412694009819 TPR motif; other site 412694009820 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 412694009821 G1 box; other site 412694009822 GTP/Mg2+ binding site [chemical binding]; other site 412694009823 Switch I region; other site 412694009824 G3 box; other site 412694009825 Switch II region; other site 412694009826 G4 box; other site 412694009827 G5 box; other site 412694009828 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 412694009829 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 412694009830 active site 412694009831 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 412694009832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694009833 ATP binding site [chemical binding]; other site 412694009834 Mg2+ binding site [ion binding]; other site 412694009835 G-X-G motif; other site 412694009836 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 412694009837 ATP binding site [chemical binding]; other site 412694009838 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 412694009839 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 412694009840 MutS domain I; Region: MutS_I; pfam01624 412694009841 MutS domain II; Region: MutS_II; pfam05188 412694009842 MutS domain III; Region: MutS_III; pfam05192 412694009843 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 412694009844 Walker A/P-loop; other site 412694009845 ATP binding site [chemical binding]; other site 412694009846 Q-loop/lid; other site 412694009847 ABC transporter signature motif; other site 412694009848 Walker B; other site 412694009849 D-loop; other site 412694009850 H-loop/switch region; other site 412694009851 Outer spore coat protein E (CotE); Region: CotE; pfam10628 412694009852 Predicted membrane protein [Function unknown]; Region: COG4550 412694009853 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 412694009854 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 412694009855 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412694009856 FeS/SAM binding site; other site 412694009857 TRAM domain; Region: TRAM; pfam01938 412694009858 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 412694009859 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 412694009860 TPP-binding site [chemical binding]; other site 412694009861 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 412694009862 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 412694009863 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 412694009864 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 412694009865 dimer interface [polypeptide binding]; other site 412694009866 PYR/PP interface [polypeptide binding]; other site 412694009867 TPP binding site [chemical binding]; other site 412694009868 substrate binding site [chemical binding]; other site 412694009869 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 412694009870 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 412694009871 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 412694009872 active site 412694009873 dimer interface [polypeptide binding]; other site 412694009874 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 412694009875 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 412694009876 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 412694009877 putative active site [active] 412694009878 metal binding site [ion binding]; metal-binding site 412694009879 homodimer binding site [polypeptide binding]; other site 412694009880 phosphodiesterase; Provisional; Region: PRK12704 412694009881 Uncharacterized conserved protein [Function unknown]; Region: COG3334 412694009882 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 412694009883 Zn2+ binding site [ion binding]; other site 412694009884 Mg2+ binding site [ion binding]; other site 412694009885 recombinase A; Provisional; Region: recA; PRK09354 412694009886 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 412694009887 hexamer interface [polypeptide binding]; other site 412694009888 Walker A motif; other site 412694009889 ATP binding site [chemical binding]; other site 412694009890 Walker B motif; other site 412694009891 competence damage-inducible protein A; Provisional; Region: PRK00549 412694009892 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 412694009893 putative MPT binding site; other site 412694009894 Competence-damaged protein; Region: CinA; pfam02464 412694009895 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 412694009896 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 412694009897 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412694009898 non-specific DNA binding site [nucleotide binding]; other site 412694009899 salt bridge; other site 412694009900 sequence-specific DNA binding site [nucleotide binding]; other site 412694009901 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 412694009902 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 412694009903 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 412694009904 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 412694009905 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 412694009906 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412694009907 NAD(P) binding site [chemical binding]; other site 412694009908 active site 412694009909 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 412694009910 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 412694009911 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 412694009912 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 412694009913 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 412694009914 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 412694009915 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 412694009916 TM-ABC transporter signature motif; other site 412694009917 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 412694009918 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 412694009919 TM-ABC transporter signature motif; other site 412694009920 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 412694009921 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 412694009922 Walker A/P-loop; other site 412694009923 ATP binding site [chemical binding]; other site 412694009924 Q-loop/lid; other site 412694009925 ABC transporter signature motif; other site 412694009926 Walker B; other site 412694009927 D-loop; other site 412694009928 H-loop/switch region; other site 412694009929 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 412694009930 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 412694009931 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 412694009932 ligand binding site [chemical binding]; other site 412694009933 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 412694009934 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412694009935 DNA-binding site [nucleotide binding]; DNA binding site 412694009936 UTRA domain; Region: UTRA; pfam07702 412694009937 Tetraspanin family; Region: Tetraspannin; pfam00335 412694009938 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 412694009939 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 412694009940 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 412694009941 YlzJ-like protein; Region: YlzJ; pfam14035 412694009942 Clp protease; Region: CLP_protease; pfam00574 412694009943 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 412694009944 active site 412694009945 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 412694009946 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 412694009947 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 412694009948 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 412694009949 dihydrodipicolinate synthase; Region: dapA; TIGR00674 412694009950 dimer interface [polypeptide binding]; other site 412694009951 active site 412694009952 catalytic residue [active] 412694009953 aspartate kinase I; Reviewed; Region: PRK08210 412694009954 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 412694009955 nucleotide binding site [chemical binding]; other site 412694009956 substrate binding site [chemical binding]; other site 412694009957 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 412694009958 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 412694009959 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 412694009960 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 412694009961 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 412694009962 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 412694009963 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 412694009964 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 412694009965 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 412694009966 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 412694009967 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 412694009968 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 412694009969 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 412694009970 NodB motif; other site 412694009971 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 412694009972 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 412694009973 RNase E interface [polypeptide binding]; other site 412694009974 trimer interface [polypeptide binding]; other site 412694009975 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 412694009976 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 412694009977 RNase E interface [polypeptide binding]; other site 412694009978 trimer interface [polypeptide binding]; other site 412694009979 active site 412694009980 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 412694009981 putative nucleic acid binding region [nucleotide binding]; other site 412694009982 G-X-X-G motif; other site 412694009983 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 412694009984 RNA binding site [nucleotide binding]; other site 412694009985 domain interface; other site 412694009986 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 412694009987 16S/18S rRNA binding site [nucleotide binding]; other site 412694009988 S13e-L30e interaction site [polypeptide binding]; other site 412694009989 25S rRNA binding site [nucleotide binding]; other site 412694009990 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 412694009991 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 412694009992 active site 412694009993 Riboflavin kinase; Region: Flavokinase; smart00904 412694009994 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 412694009995 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 412694009996 RNA binding site [nucleotide binding]; other site 412694009997 active site 412694009998 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 412694009999 Protein of unknown function (DUF503); Region: DUF503; pfam04456 412694010000 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 412694010001 translation initiation factor IF-2; Region: IF-2; TIGR00487 412694010002 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 412694010003 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 412694010004 G1 box; other site 412694010005 putative GEF interaction site [polypeptide binding]; other site 412694010006 GTP/Mg2+ binding site [chemical binding]; other site 412694010007 Switch I region; other site 412694010008 G2 box; other site 412694010009 G3 box; other site 412694010010 Switch II region; other site 412694010011 G4 box; other site 412694010012 G5 box; other site 412694010013 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 412694010014 Translation-initiation factor 2; Region: IF-2; pfam11987 412694010015 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 412694010016 hypothetical protein; Provisional; Region: PRK07714 412694010017 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 412694010018 putative RNA binding cleft [nucleotide binding]; other site 412694010019 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 412694010020 NusA N-terminal domain; Region: NusA_N; pfam08529 412694010021 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 412694010022 RNA binding site [nucleotide binding]; other site 412694010023 homodimer interface [polypeptide binding]; other site 412694010024 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 412694010025 G-X-X-G motif; other site 412694010026 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 412694010027 G-X-X-G motif; other site 412694010028 ribosome maturation protein RimP; Reviewed; Region: PRK00092 412694010029 Sm and related proteins; Region: Sm_like; cl00259 412694010030 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 412694010031 putative oligomer interface [polypeptide binding]; other site 412694010032 putative RNA binding site [nucleotide binding]; other site 412694010033 DNA polymerase III PolC; Validated; Region: polC; PRK00448 412694010034 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 412694010035 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 412694010036 putative active site [active] 412694010037 putative NTP binding site [chemical binding]; other site 412694010038 putative nucleic acid binding site [nucleotide binding]; other site 412694010039 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 412694010040 active site 412694010041 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 412694010042 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 412694010043 generic binding surface II; other site 412694010044 generic binding surface I; other site 412694010045 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 412694010046 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 412694010047 active site 412694010048 exonuclease, DNA polymerase III, epsilon subunit family; Region: dnaq; TIGR00573 412694010049 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 412694010050 active site 412694010051 catalytic site [active] 412694010052 substrate binding site [chemical binding]; other site 412694010053 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 412694010054 prolyl-tRNA synthetase; Provisional; Region: PRK09194 412694010055 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 412694010056 dimer interface [polypeptide binding]; other site 412694010057 motif 1; other site 412694010058 active site 412694010059 motif 2; other site 412694010060 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 412694010061 putative deacylase active site [active] 412694010062 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 412694010063 active site 412694010064 motif 3; other site 412694010065 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 412694010066 anticodon binding site; other site 412694010067 RIP metalloprotease RseP; Region: TIGR00054 412694010068 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 412694010069 active site 412694010070 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 412694010071 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 412694010072 protein binding site [polypeptide binding]; other site 412694010073 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 412694010074 putative substrate binding region [chemical binding]; other site 412694010075 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 412694010076 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 412694010077 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 412694010078 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 412694010079 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 412694010080 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 412694010081 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 412694010082 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 412694010083 catalytic residue [active] 412694010084 putative FPP diphosphate binding site; other site 412694010085 putative FPP binding hydrophobic cleft; other site 412694010086 dimer interface [polypeptide binding]; other site 412694010087 putative IPP diphosphate binding site; other site 412694010088 ribosome recycling factor; Reviewed; Region: frr; PRK00083 412694010089 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 412694010090 hinge region; other site 412694010091 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 412694010092 putative nucleotide binding site [chemical binding]; other site 412694010093 uridine monophosphate binding site [chemical binding]; other site 412694010094 homohexameric interface [polypeptide binding]; other site 412694010095 elongation factor Ts; Provisional; Region: tsf; PRK09377 412694010096 UBA/TS-N domain; Region: UBA; pfam00627 412694010097 Elongation factor TS; Region: EF_TS; pfam00889 412694010098 Elongation factor TS; Region: EF_TS; pfam00889 412694010099 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 412694010100 rRNA interaction site [nucleotide binding]; other site 412694010101 S8 interaction site; other site 412694010102 putative laminin-1 binding site; other site 412694010103 transcriptional repressor CodY; Validated; Region: PRK04158 412694010104 CodY GAF-like domain; Region: CodY; pfam06018 412694010105 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 412694010106 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 412694010107 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412694010108 Walker A motif; other site 412694010109 ATP binding site [chemical binding]; other site 412694010110 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 412694010111 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 412694010112 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 412694010113 active site 412694010114 HslU subunit interaction site [polypeptide binding]; other site 412694010115 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 412694010116 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 412694010117 active site 412694010118 Int/Topo IB signature motif; other site 412694010119 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 412694010120 Glucose inhibited division protein A; Region: GIDA; pfam01134 412694010121 DNA topoisomerase I; Validated; Region: PRK05582 412694010122 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 412694010123 active site 412694010124 interdomain interaction site; other site 412694010125 putative metal-binding site [ion binding]; other site 412694010126 nucleotide binding site [chemical binding]; other site 412694010127 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 412694010128 domain I; other site 412694010129 DNA binding groove [nucleotide binding] 412694010130 phosphate binding site [ion binding]; other site 412694010131 domain II; other site 412694010132 domain III; other site 412694010133 nucleotide binding site [chemical binding]; other site 412694010134 catalytic site [active] 412694010135 domain IV; other site 412694010136 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 412694010137 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 412694010138 DNA protecting protein DprA; Region: dprA; TIGR00732 412694010139 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 412694010140 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 412694010141 CoA binding domain; Region: CoA_binding; smart00881 412694010142 CoA-ligase; Region: Ligase_CoA; pfam00549 412694010143 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 412694010144 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 412694010145 CoA-ligase; Region: Ligase_CoA; pfam00549 412694010146 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 412694010147 RNA/DNA hybrid binding site [nucleotide binding]; other site 412694010148 active site 412694010149 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 412694010150 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 412694010151 GTP/Mg2+ binding site [chemical binding]; other site 412694010152 G4 box; other site 412694010153 G5 box; other site 412694010154 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 412694010155 G1 box; other site 412694010156 G1 box; other site 412694010157 GTP/Mg2+ binding site [chemical binding]; other site 412694010158 Switch I region; other site 412694010159 G2 box; other site 412694010160 G2 box; other site 412694010161 G3 box; other site 412694010162 G3 box; other site 412694010163 Switch II region; other site 412694010164 Switch II region; other site 412694010165 G4 box; other site 412694010166 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 412694010167 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 412694010168 Catalytic site [active] 412694010169 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 412694010170 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 412694010171 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 412694010172 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 412694010173 RimM N-terminal domain; Region: RimM; pfam01782 412694010174 PRC-barrel domain; Region: PRC; pfam05239 412694010175 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 412694010176 KH domain; Region: KH_4; pfam13083 412694010177 G-X-X-G motif; other site 412694010178 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 412694010179 signal recognition particle protein; Provisional; Region: PRK10867 412694010180 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 412694010181 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 412694010182 P loop; other site 412694010183 GTP binding site [chemical binding]; other site 412694010184 Signal peptide binding domain; Region: SRP_SPB; pfam02978 412694010185 putative DNA-binding protein; Validated; Region: PRK00118 412694010186 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 412694010187 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 412694010188 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 412694010189 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 412694010190 P loop; other site 412694010191 GTP binding site [chemical binding]; other site 412694010192 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 412694010193 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 412694010194 Walker A/P-loop; other site 412694010195 ATP binding site [chemical binding]; other site 412694010196 Q-loop/lid; other site 412694010197 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 412694010198 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 412694010199 ABC transporter signature motif; other site 412694010200 Walker B; other site 412694010201 D-loop; other site 412694010202 H-loop/switch region; other site 412694010203 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 412694010204 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 412694010205 dimerization interface [polypeptide binding]; other site 412694010206 active site 412694010207 metal binding site [ion binding]; metal-binding site 412694010208 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 412694010209 dsRNA binding site [nucleotide binding]; other site 412694010210 acyl carrier protein; Provisional; Region: acpP; PRK00982 412694010211 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 412694010212 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 412694010213 NAD(P) binding site [chemical binding]; other site 412694010214 homotetramer interface [polypeptide binding]; other site 412694010215 homodimer interface [polypeptide binding]; other site 412694010216 active site 412694010217 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 412694010218 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 412694010219 putative phosphate acyltransferase; Provisional; Region: PRK05331 412694010220 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 412694010221 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 412694010222 active site 2 [active] 412694010223 active site 1 [active] 412694010224 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 412694010225 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 412694010226 generic binding surface II; other site 412694010227 ssDNA binding site; other site 412694010228 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 412694010229 ATP binding site [chemical binding]; other site 412694010230 putative Mg++ binding site [ion binding]; other site 412694010231 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412694010232 nucleotide binding region [chemical binding]; other site 412694010233 ATP-binding site [chemical binding]; other site 412694010234 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 412694010235 DAK2 domain; Region: Dak2; pfam02734 412694010236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 412694010237 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 412694010238 Thiamine pyrophosphokinase; Region: TPK; cd07995 412694010239 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 412694010240 active site 412694010241 dimerization interface [polypeptide binding]; other site 412694010242 thiamine binding site [chemical binding]; other site 412694010243 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 412694010244 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 412694010245 substrate binding site [chemical binding]; other site 412694010246 hexamer interface [polypeptide binding]; other site 412694010247 metal binding site [ion binding]; metal-binding site 412694010248 GTPase RsgA; Reviewed; Region: PRK00098 412694010249 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 412694010250 RNA binding site [nucleotide binding]; other site 412694010251 homodimer interface [polypeptide binding]; other site 412694010252 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 412694010253 GTPase/Zn-binding domain interface [polypeptide binding]; other site 412694010254 GTP/Mg2+ binding site [chemical binding]; other site 412694010255 G4 box; other site 412694010256 G5 box; other site 412694010257 G1 box; other site 412694010258 Switch I region; other site 412694010259 G2 box; other site 412694010260 G3 box; other site 412694010261 Switch II region; other site 412694010262 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 412694010263 Catalytic domain of Protein Kinases; Region: PKc; cd00180 412694010264 active site 412694010265 ATP binding site [chemical binding]; other site 412694010266 substrate binding site [chemical binding]; other site 412694010267 activation loop (A-loop); other site 412694010268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 412694010269 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 412694010270 PASTA domain; Region: PASTA; pfam03793 412694010271 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 412694010272 Protein phosphatase 2C; Region: PP2C; pfam00481 412694010273 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 412694010274 active site 412694010275 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 412694010276 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412694010277 FeS/SAM binding site; other site 412694010278 16S rRNA methyltransferase B; Provisional; Region: PRK14902 412694010279 NusB family; Region: NusB; pfam01029 412694010280 putative RNA binding site [nucleotide binding]; other site 412694010281 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694010282 S-adenosylmethionine binding site [chemical binding]; other site 412694010283 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 412694010284 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 412694010285 putative active site [active] 412694010286 substrate binding site [chemical binding]; other site 412694010287 putative cosubstrate binding site; other site 412694010288 catalytic site [active] 412694010289 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 412694010290 substrate binding site [chemical binding]; other site 412694010291 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 412694010292 active site 412694010293 catalytic residues [active] 412694010294 metal binding site [ion binding]; metal-binding site 412694010295 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 412694010296 primosomal protein N' Region: priA; TIGR00595 412694010297 ATP binding site [chemical binding]; other site 412694010298 putative Mg++ binding site [ion binding]; other site 412694010299 helicase superfamily c-terminal domain; Region: HELICc; smart00490 412694010300 nucleotide binding region [chemical binding]; other site 412694010301 ATP-binding site [chemical binding]; other site 412694010302 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 412694010303 Flavoprotein; Region: Flavoprotein; pfam02441 412694010304 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 412694010305 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 412694010306 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 412694010307 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 412694010308 catalytic site [active] 412694010309 G-X2-G-X-G-K; other site 412694010310 hypothetical protein; Provisional; Region: PRK04323 412694010311 hypothetical protein; Provisional; Region: PRK11820 412694010312 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 412694010313 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 412694010314 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 412694010315 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 412694010316 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 412694010317 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 412694010318 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412694010319 motif II; other site 412694010320 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 412694010321 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 412694010322 Domain of unknown function (DUF814); Region: DUF814; pfam05670 412694010323 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 412694010324 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 412694010325 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 412694010326 active site 412694010327 Protein of unknown function (DUF664); Region: DUF664; pfam04978 412694010328 DinB superfamily; Region: DinB_2; pfam12867 412694010329 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 412694010330 Transposase; Region: HTH_Tnp_1; pfam01527 412694010331 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 412694010332 HTH-like domain; Region: HTH_21; pfam13276 412694010333 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412694010334 Integrase core domain; Region: rve; pfam00665 412694010335 Integrase core domain; Region: rve_2; pfam13333 412694010336 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 412694010337 active site 412694010338 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 412694010339 active site 412694010340 dimer interface [polypeptide binding]; other site 412694010341 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 412694010342 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 412694010343 heterodimer interface [polypeptide binding]; other site 412694010344 active site 412694010345 FMN binding site [chemical binding]; other site 412694010346 homodimer interface [polypeptide binding]; other site 412694010347 substrate binding site [chemical binding]; other site 412694010348 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 412694010349 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 412694010350 FAD binding pocket [chemical binding]; other site 412694010351 FAD binding motif [chemical binding]; other site 412694010352 phosphate binding motif [ion binding]; other site 412694010353 beta-alpha-beta structure motif; other site 412694010354 NAD binding pocket [chemical binding]; other site 412694010355 Iron coordination center [ion binding]; other site 412694010356 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 412694010357 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 412694010358 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 412694010359 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 412694010360 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 412694010361 ATP-grasp domain; Region: ATP-grasp_4; cl17255 412694010362 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 412694010363 IMP binding site; other site 412694010364 dimer interface [polypeptide binding]; other site 412694010365 interdomain contacts; other site 412694010366 partial ornithine binding site; other site 412694010367 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 412694010368 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 412694010369 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 412694010370 catalytic site [active] 412694010371 subunit interface [polypeptide binding]; other site 412694010372 dihydroorotase; Validated; Region: pyrC; PRK09357 412694010373 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 412694010374 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 412694010375 active site 412694010376 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 412694010377 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 412694010378 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 412694010379 uracil transporter; Provisional; Region: PRK10720 412694010380 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 412694010381 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 412694010382 active site 412694010383 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 412694010384 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 412694010385 RNA binding surface [nucleotide binding]; other site 412694010386 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 412694010387 active site 412694010388 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 412694010389 lipoprotein signal peptidase; Provisional; Region: PRK14787 412694010390 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 412694010391 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 412694010392 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 412694010393 active site 412694010394 HIGH motif; other site 412694010395 nucleotide binding site [chemical binding]; other site 412694010396 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 412694010397 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 412694010398 active site 412694010399 KMSKS motif; other site 412694010400 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 412694010401 tRNA binding surface [nucleotide binding]; other site 412694010402 anticodon binding site; other site 412694010403 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 412694010404 DivIVA protein; Region: DivIVA; pfam05103 412694010405 DivIVA domain; Region: DivI1A_domain; TIGR03544 412694010406 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 412694010407 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 412694010408 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 412694010409 RNA binding surface [nucleotide binding]; other site 412694010410 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 412694010411 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 412694010412 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 412694010413 catalytic residue [active] 412694010414 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 412694010415 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 412694010416 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 412694010417 sporulation sigma factor SigG; Reviewed; Region: PRK08215 412694010418 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412694010419 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 412694010420 DNA binding residues [nucleotide binding] 412694010421 sporulation sigma factor SigE; Reviewed; Region: PRK08301 412694010422 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412694010423 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 412694010424 DNA binding residues [nucleotide binding] 412694010425 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 412694010426 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 412694010427 cell division protein FtsZ; Validated; Region: PRK09330 412694010428 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 412694010429 nucleotide binding site [chemical binding]; other site 412694010430 SulA interaction site; other site 412694010431 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 412694010432 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 412694010433 nucleotide binding site [chemical binding]; other site 412694010434 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 412694010435 Cell division protein FtsA; Region: FtsA; pfam14450 412694010436 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 412694010437 Cell division protein FtsQ; Region: FtsQ; pfam03799 412694010438 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 412694010439 FAD binding domain; Region: FAD_binding_4; pfam01565 412694010440 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 412694010441 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 412694010442 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 412694010443 active site 412694010444 homodimer interface [polypeptide binding]; other site 412694010445 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 412694010446 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 412694010447 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 412694010448 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 412694010449 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 412694010450 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 412694010451 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 412694010452 Mg++ binding site [ion binding]; other site 412694010453 putative catalytic motif [active] 412694010454 putative substrate binding site [chemical binding]; other site 412694010455 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 412694010456 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 412694010457 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 412694010458 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 412694010459 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 412694010460 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 412694010461 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 412694010462 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 412694010463 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 412694010464 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 412694010465 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 412694010466 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 412694010467 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 412694010468 Cell division protein FtsL; Region: FtsL; cl11433 412694010469 MraW methylase family; Region: Methyltransf_5; pfam01795 412694010470 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 412694010471 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 412694010472 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 412694010473 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 412694010474 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 412694010475 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 412694010476 hypothetical protein; Provisional; Region: PRK13688 412694010477 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694010478 Coenzyme A binding pocket [chemical binding]; other site 412694010479 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 412694010480 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 412694010481 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 412694010482 hypothetical protein; Provisional; Region: PRK13670 412694010483 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 412694010484 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 412694010485 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 412694010486 protein binding site [polypeptide binding]; other site 412694010487 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 412694010488 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 412694010489 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 412694010490 active site 412694010491 nucleophile elbow; other site 412694010492 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 412694010493 Nucleoside recognition; Region: Gate; pfam07670 412694010494 Nucleoside recognition; Region: Gate; pfam07670 412694010495 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 412694010496 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 412694010497 active site 412694010498 (T/H)XGH motif; other site 412694010499 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 412694010500 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694010501 S-adenosylmethionine binding site [chemical binding]; other site 412694010502 Protein of unknown function (DUF964); Region: DUF964; pfam06133 412694010503 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 412694010504 catalytic core [active] 412694010505 YlbE-like protein; Region: YlbE; pfam14003 412694010506 Putative coat protein; Region: YlbD_coat; pfam14071 412694010507 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 412694010508 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 412694010509 YugN-like family; Region: YugN; pfam08868 412694010510 formamidase; Provisional; Region: amiF; PRK13287 412694010511 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 412694010512 multimer interface [polypeptide binding]; other site 412694010513 active site 412694010514 catalytic triad [active] 412694010515 dimer interface [polypeptide binding]; other site 412694010516 cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737 412694010517 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 412694010518 Subunit I/III interface [polypeptide binding]; other site 412694010519 Subunit III/IV interface [polypeptide binding]; other site 412694010520 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 412694010521 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 412694010522 D-pathway; other site 412694010523 Putative ubiquinol binding site [chemical binding]; other site 412694010524 Low-spin heme (heme b) binding site [chemical binding]; other site 412694010525 Putative water exit pathway; other site 412694010526 Binuclear center (heme o3/CuB) [ion binding]; other site 412694010527 K-pathway; other site 412694010528 Putative proton exit pathway; other site 412694010529 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 412694010530 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 412694010531 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 412694010532 Cytochrome c; Region: Cytochrom_C; pfam00034 412694010533 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 412694010534 UbiA prenyltransferase family; Region: UbiA; pfam01040 412694010535 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 412694010536 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 412694010537 pyruvate carboxylase; Reviewed; Region: PRK12999 412694010538 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 412694010539 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 412694010540 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 412694010541 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 412694010542 active site 412694010543 catalytic residues [active] 412694010544 metal binding site [ion binding]; metal-binding site 412694010545 homodimer binding site [polypeptide binding]; other site 412694010546 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 412694010547 carboxyltransferase (CT) interaction site; other site 412694010548 biotinylation site [posttranslational modification]; other site 412694010549 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 412694010550 hypothetical protein; Provisional; Region: PRK13666 412694010551 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 412694010552 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 412694010553 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 412694010554 putative active site [active] 412694010555 PhoH-like protein; Region: PhoH; pfam02562 412694010556 hypothetical protein; Provisional; Region: PRK06733 412694010557 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 412694010558 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 412694010559 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 412694010560 G1 box; other site 412694010561 putative GEF interaction site [polypeptide binding]; other site 412694010562 GTP/Mg2+ binding site [chemical binding]; other site 412694010563 Switch I region; other site 412694010564 G2 box; other site 412694010565 G3 box; other site 412694010566 Switch II region; other site 412694010567 G4 box; other site 412694010568 G5 box; other site 412694010569 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 412694010570 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 412694010571 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 412694010572 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 412694010573 active site 412694010574 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 412694010575 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 412694010576 hypothetical protein; Provisional; Region: PRK04387 412694010577 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 412694010578 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 412694010579 homodimer interface [polypeptide binding]; other site 412694010580 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694010581 catalytic residue [active] 412694010582 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 412694010583 transglutaminase; Provisional; Region: tgl; PRK03187 412694010584 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 412694010585 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 412694010586 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 412694010587 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 412694010588 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 412694010589 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 412694010590 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 412694010591 E3 interaction surface; other site 412694010592 lipoyl attachment site [posttranslational modification]; other site 412694010593 e3 binding domain; Region: E3_binding; pfam02817 412694010594 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 412694010595 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 412694010596 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 412694010597 alpha subunit interface [polypeptide binding]; other site 412694010598 TPP binding site [chemical binding]; other site 412694010599 heterodimer interface [polypeptide binding]; other site 412694010600 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 412694010601 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 412694010602 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 412694010603 TPP-binding site [chemical binding]; other site 412694010604 heterodimer interface [polypeptide binding]; other site 412694010605 tetramer interface [polypeptide binding]; other site 412694010606 phosphorylation loop region [posttranslational modification] 412694010607 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 412694010608 active site 412694010609 catalytic residues [active] 412694010610 metal binding site [ion binding]; metal-binding site 412694010611 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412694010612 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 412694010613 active site 412694010614 motif I; other site 412694010615 motif II; other site 412694010616 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412694010617 hypothetical protein; Provisional; Region: PRK13667 412694010618 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 412694010619 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 412694010620 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 412694010621 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 412694010622 TrkA-N domain; Region: TrkA_N; pfam02254 412694010623 TrkA-C domain; Region: TrkA_C; pfam02080 412694010624 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 412694010625 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 412694010626 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 412694010627 metal binding site [ion binding]; metal-binding site 412694010628 putative dimer interface [polypeptide binding]; other site 412694010629 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 412694010630 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 412694010631 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 412694010632 trimer interface [polypeptide binding]; other site 412694010633 active site 412694010634 substrate binding site [chemical binding]; other site 412694010635 CoA binding site [chemical binding]; other site 412694010636 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412694010637 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412694010638 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 412694010639 dimerization interface [polypeptide binding]; other site 412694010640 FOG: CBS domain [General function prediction only]; Region: COG0517 412694010641 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 412694010642 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 412694010643 Protein of unknown function (DUF458); Region: DUF458; pfam04308 412694010644 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 412694010645 catalytic residues [active] 412694010646 Protein of unknown function (DUF3993); Region: DUF3993; pfam13158 412694010647 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 412694010648 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 412694010649 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 412694010650 short chain dehydrogenase; Provisional; Region: PRK07677 412694010651 NAD(P) binding site [chemical binding]; other site 412694010652 substrate binding site [chemical binding]; other site 412694010653 homotetramer interface [polypeptide binding]; other site 412694010654 active site 412694010655 homodimer interface [polypeptide binding]; other site 412694010656 phosphodiesterase YaeI; Provisional; Region: PRK11340 412694010657 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 412694010658 putative active site [active] 412694010659 putative metal binding site [ion binding]; other site 412694010660 polyphosphate kinase; Provisional; Region: PRK05443 412694010661 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 412694010662 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 412694010663 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 412694010664 putative domain interface [polypeptide binding]; other site 412694010665 putative active site [active] 412694010666 catalytic site [active] 412694010667 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 412694010668 putative domain interface [polypeptide binding]; other site 412694010669 putative active site [active] 412694010670 catalytic site [active] 412694010671 exopolyphosphatase; Region: exo_poly_only; TIGR03706 412694010672 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 412694010673 YkyB-like protein; Region: YkyB; pfam14177 412694010674 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 412694010675 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 412694010676 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 412694010677 I-site; other site 412694010678 active site 412694010679 metal binding site [ion binding]; metal-binding site 412694010680 Phage lysis protein, holin; Region: Phage_holin; cl04675 412694010681 Major Facilitator Superfamily; Region: MFS_1; pfam07690 412694010682 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694010683 putative substrate translocation pore; other site 412694010684 Predicted transcriptional regulators [Transcription]; Region: COG1695 412694010685 Transcriptional regulator PadR-like family; Region: PadR; cl17335 412694010686 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 412694010687 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 412694010688 THF binding site; other site 412694010689 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 412694010690 substrate binding site [chemical binding]; other site 412694010691 THF binding site; other site 412694010692 zinc-binding site [ion binding]; other site 412694010693 Competence protein J (ComJ); Region: ComJ; pfam11033 412694010694 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 412694010695 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 412694010696 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412694010697 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694010698 dimer interface [polypeptide binding]; other site 412694010699 phosphorylation site [posttranslational modification] 412694010700 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694010701 ATP binding site [chemical binding]; other site 412694010702 Mg2+ binding site [ion binding]; other site 412694010703 G-X-G motif; other site 412694010704 aminotransferase A; Validated; Region: PRK07683 412694010705 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412694010706 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694010707 homodimer interface [polypeptide binding]; other site 412694010708 catalytic residue [active] 412694010709 Transcriptional regulators [Transcription]; Region: PurR; COG1609 412694010710 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 412694010711 DNA binding site [nucleotide binding] 412694010712 domain linker motif; other site 412694010713 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 412694010714 putative dimerization interface [polypeptide binding]; other site 412694010715 putative ligand binding site [chemical binding]; other site 412694010716 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 412694010717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694010718 dimer interface [polypeptide binding]; other site 412694010719 conserved gate region; other site 412694010720 putative PBP binding loops; other site 412694010721 ABC-ATPase subunit interface; other site 412694010722 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 412694010723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694010724 dimer interface [polypeptide binding]; other site 412694010725 conserved gate region; other site 412694010726 putative PBP binding loops; other site 412694010727 ABC-ATPase subunit interface; other site 412694010728 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 412694010729 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 412694010730 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 412694010731 homodimer interface [polypeptide binding]; other site 412694010732 maltodextrin glucosidase; Provisional; Region: PRK10785 412694010733 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 412694010734 active site 412694010735 homodimer interface [polypeptide binding]; other site 412694010736 catalytic site [active] 412694010737 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 412694010738 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 412694010739 Ca binding site [ion binding]; other site 412694010740 active site 412694010741 catalytic site [active] 412694010742 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 412694010743 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 412694010744 Walker A/P-loop; other site 412694010745 ATP binding site [chemical binding]; other site 412694010746 Q-loop/lid; other site 412694010747 ABC transporter signature motif; other site 412694010748 Walker B; other site 412694010749 D-loop; other site 412694010750 H-loop/switch region; other site 412694010751 TOBE domain; Region: TOBE_2; pfam08402 412694010752 hypothetical protein; Provisional; Region: PRK06720 412694010753 NAD(P) binding site [chemical binding]; other site 412694010754 Protein of unknown function (DUF3997); Region: DUF3997; pfam13162 412694010755 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 412694010756 Predicted ATPase [General function prediction only]; Region: COG3910 412694010757 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412694010758 Walker A/P-loop; other site 412694010759 ATP binding site [chemical binding]; other site 412694010760 Q-loop/lid; other site 412694010761 ABC transporter signature motif; other site 412694010762 Walker B; other site 412694010763 D-loop; other site 412694010764 H-loop/switch region; other site 412694010765 putative acyltransferase; Provisional; Region: PRK05790 412694010766 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 412694010767 dimer interface [polypeptide binding]; other site 412694010768 active site 412694010769 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 412694010770 nudix motif; other site 412694010771 Protein of unknown function (DUF3928); Region: DUF3928; pfam13065 412694010772 hypothetical protein; Validated; Region: PRK07668 412694010773 hypothetical protein; Validated; Region: PRK07668 412694010774 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 412694010775 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412694010776 NAD(P) binding site [chemical binding]; other site 412694010777 active site 412694010778 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 412694010779 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 412694010780 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 412694010781 Phosphotransferase enzyme family; Region: APH; pfam01636 412694010782 Predicted amidohydrolase [General function prediction only]; Region: COG0388 412694010783 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 412694010784 putative active site [active] 412694010785 catalytic triad [active] 412694010786 putative dimer interface [polypeptide binding]; other site 412694010787 transaminase; Reviewed; Region: PRK08068 412694010788 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412694010789 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694010790 homodimer interface [polypeptide binding]; other site 412694010791 catalytic residue [active] 412694010792 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: salvage_mtnW; TIGR03332 412694010793 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 412694010794 dimer interface [polypeptide binding]; other site 412694010795 active site 412694010796 catalytic residue [active] 412694010797 metal binding site [ion binding]; metal-binding site 412694010798 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase; Reviewed; Region: mtnX; PRK09552 412694010799 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 412694010800 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 412694010801 intersubunit interface [polypeptide binding]; other site 412694010802 active site 412694010803 Zn2+ binding site [ion binding]; other site 412694010804 ARD/ARD' family; Region: ARD; pfam03079 412694010805 Cupin domain; Region: Cupin_2; pfam07883 412694010806 Protein of unknown function (DUF3909); Region: DUF3909; pfam13077 412694010807 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 412694010808 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 412694010809 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 412694010810 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 412694010811 metal binding site [ion binding]; metal-binding site 412694010812 active site 412694010813 I-site; other site 412694010814 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 412694010815 dimer interface [polypeptide binding]; other site 412694010816 FMN binding site [chemical binding]; other site 412694010817 Protein of unknown function (DUF3915); Region: DUF3915; pfam13054 412694010818 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 412694010819 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 412694010820 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 412694010821 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 412694010822 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 412694010823 dimerization domain swap beta strand [polypeptide binding]; other site 412694010824 regulatory protein interface [polypeptide binding]; other site 412694010825 active site 412694010826 regulatory phosphorylation site [posttranslational modification]; other site 412694010827 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 412694010828 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 412694010829 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 412694010830 active site turn [active] 412694010831 phosphorylation site [posttranslational modification] 412694010832 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 412694010833 HPr interaction site; other site 412694010834 glycerol kinase (GK) interaction site [polypeptide binding]; other site 412694010835 active site 412694010836 phosphorylation site [posttranslational modification] 412694010837 transcriptional antiterminator BglG; Provisional; Region: PRK09772 412694010838 CAT RNA binding domain; Region: CAT_RBD; smart01061 412694010839 PRD domain; Region: PRD; pfam00874 412694010840 PRD domain; Region: PRD; pfam00874 412694010841 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 412694010842 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412694010843 active site 412694010844 motif I; other site 412694010845 motif II; other site 412694010846 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412694010847 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 412694010848 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412694010849 DNA-binding site [nucleotide binding]; DNA binding site 412694010850 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 412694010851 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 412694010852 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 412694010853 active site 412694010854 trimer interface [polypeptide binding]; other site 412694010855 allosteric site; other site 412694010856 active site lid [active] 412694010857 hexamer (dimer of trimers) interface [polypeptide binding]; other site 412694010858 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 412694010859 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 412694010860 active site 412694010861 dimer interface [polypeptide binding]; other site 412694010862 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 412694010863 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 412694010864 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 412694010865 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 412694010866 Domain of unknown function (DUF309); Region: DUF309; pfam03745 412694010867 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694010868 Coenzyme A binding pocket [chemical binding]; other site 412694010869 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 412694010870 active site 412694010871 Predicted secreted protein [Function unknown]; Region: COG4086 412694010872 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 412694010873 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 412694010874 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 412694010875 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 412694010876 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 412694010877 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 412694010878 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 412694010879 stage V sporulation protein AD; Validated; Region: PRK08304 412694010880 stage V sporulation protein AD; Provisional; Region: PRK12404 412694010881 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 412694010882 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 412694010883 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 412694010884 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 412694010885 Na2 binding site [ion binding]; other site 412694010886 putative substrate binding site 1 [chemical binding]; other site 412694010887 Na binding site 1 [ion binding]; other site 412694010888 putative substrate binding site 2 [chemical binding]; other site 412694010889 sporulation sigma factor SigF; Validated; Region: PRK05572 412694010890 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412694010891 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 412694010892 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 412694010893 DNA binding residues [nucleotide binding] 412694010894 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 412694010895 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694010896 ATP binding site [chemical binding]; other site 412694010897 Mg2+ binding site [ion binding]; other site 412694010898 G-X-G motif; other site 412694010899 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 412694010900 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 412694010901 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 412694010902 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 412694010903 Predicted transcriptional regulators [Transcription]; Region: COG1725 412694010904 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412694010905 DNA-binding site [nucleotide binding]; DNA binding site 412694010906 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 412694010907 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 412694010908 Walker A/P-loop; other site 412694010909 ATP binding site [chemical binding]; other site 412694010910 Q-loop/lid; other site 412694010911 ABC transporter signature motif; other site 412694010912 Walker B; other site 412694010913 D-loop; other site 412694010914 H-loop/switch region; other site 412694010915 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 412694010916 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 412694010917 MarR family; Region: MarR; pfam01047 412694010918 MarR family; Region: MarR_2; cl17246 412694010919 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 412694010920 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 412694010921 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 412694010922 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 412694010923 oligomer interface [polypeptide binding]; other site 412694010924 metal binding site [ion binding]; metal-binding site 412694010925 metal binding site [ion binding]; metal-binding site 412694010926 putative Cl binding site [ion binding]; other site 412694010927 aspartate ring; other site 412694010928 basic sphincter; other site 412694010929 hydrophobic gate; other site 412694010930 periplasmic entrance; other site 412694010931 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 412694010932 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 412694010933 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 412694010934 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 412694010935 purine nucleoside phosphorylase; Provisional; Region: PRK08202 412694010936 phosphopentomutase; Provisional; Region: PRK05362 412694010937 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 412694010938 YtkA-like; Region: YtkA; pfam13115 412694010939 YtkA-like; Region: YtkA; pfam13115 412694010940 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 412694010941 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 412694010942 active site 412694010943 Int/Topo IB signature motif; other site 412694010944 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 412694010945 ferric uptake regulator; Provisional; Region: fur; PRK09462 412694010946 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 412694010947 metal binding site 2 [ion binding]; metal-binding site 412694010948 putative DNA binding helix; other site 412694010949 metal binding site 1 [ion binding]; metal-binding site 412694010950 dimer interface [polypeptide binding]; other site 412694010951 structural Zn2+ binding site [ion binding]; other site 412694010952 stage II sporulation protein M; Region: spo_II_M; TIGR02831 412694010953 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 412694010954 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 412694010955 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 412694010956 dimer interface [polypeptide binding]; other site 412694010957 ADP-ribose binding site [chemical binding]; other site 412694010958 active site 412694010959 nudix motif; other site 412694010960 metal binding site [ion binding]; metal-binding site 412694010961 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 412694010962 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 412694010963 active site 412694010964 catalytic tetrad [active] 412694010965 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 412694010966 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 412694010967 active site 412694010968 catalytic tetrad [active] 412694010969 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 412694010970 Protein of unknown function (DUF3886); Region: DUF3886; pfam13025 412694010971 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 412694010972 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 412694010973 putative active site [active] 412694010974 putative metal binding site [ion binding]; other site 412694010975 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 412694010976 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 412694010977 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 412694010978 Predicted permease [General function prediction only]; Region: COG2056 412694010979 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 412694010980 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 412694010981 Transcriptional regulators [Transcription]; Region: PurR; COG1609 412694010982 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 412694010983 DNA binding site [nucleotide binding] 412694010984 domain linker motif; other site 412694010985 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 412694010986 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 412694010987 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 412694010988 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 412694010989 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 412694010990 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 412694010991 catalytic motif [active] 412694010992 Zn binding site [ion binding]; other site 412694010993 RibD C-terminal domain; Region: RibD_C; cl17279 412694010994 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 412694010995 Lumazine binding domain; Region: Lum_binding; pfam00677 412694010996 Lumazine binding domain; Region: Lum_binding; pfam00677 412694010997 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 412694010998 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 412694010999 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 412694011000 dimerization interface [polypeptide binding]; other site 412694011001 active site 412694011002 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 412694011003 homopentamer interface [polypeptide binding]; other site 412694011004 active site 412694011005 biotin synthase; Validated; Region: PRK06256 412694011006 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412694011007 FeS/SAM binding site; other site 412694011008 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 412694011009 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 412694011010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694011011 S-adenosylmethionine binding site [chemical binding]; other site 412694011012 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 412694011013 TAP-like protein; Region: Abhydrolase_4; pfam08386 412694011014 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 412694011015 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 412694011016 substrate-cofactor binding pocket; other site 412694011017 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694011018 catalytic residue [active] 412694011019 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 412694011020 AAA domain; Region: AAA_26; pfam13500 412694011021 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 412694011022 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 412694011023 inhibitor-cofactor binding pocket; inhibition site 412694011024 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694011025 catalytic residue [active] 412694011026 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 412694011027 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09418 412694011028 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 412694011029 active site 412694011030 metal binding site [ion binding]; metal-binding site 412694011031 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 412694011032 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 412694011033 active site 412694011034 catalytic triad [active] 412694011035 oxyanion hole [active] 412694011036 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412694011037 dimerization interface [polypeptide binding]; other site 412694011038 putative DNA binding site [nucleotide binding]; other site 412694011039 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 412694011040 putative Zn2+ binding site [ion binding]; other site 412694011041 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 412694011042 ornithine carbamoyltransferase; Provisional; Region: PRK00779 412694011043 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 412694011044 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 412694011045 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 412694011046 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 412694011047 inhibitor-cofactor binding pocket; inhibition site 412694011048 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694011049 catalytic residue [active] 412694011050 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 412694011051 nucleotide binding site [chemical binding]; other site 412694011052 N-acetyl-L-glutamate binding site [chemical binding]; other site 412694011053 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 412694011054 heterotetramer interface [polypeptide binding]; other site 412694011055 active site pocket [active] 412694011056 cleavage site 412694011057 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 412694011058 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 412694011059 YqzH-like protein; Region: YqzH; pfam14164 412694011060 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 412694011061 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412694011062 NAD(P) binding site [chemical binding]; other site 412694011063 active site 412694011064 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 412694011065 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07679 412694011066 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 412694011067 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 412694011068 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 412694011069 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 412694011070 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 412694011071 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 412694011072 putative L-serine binding site [chemical binding]; other site 412694011073 ribonuclease Z; Region: RNase_Z; TIGR02651 412694011074 Protein of unknown function (DUF3932); Region: DUF3932; pfam13068 412694011075 DNA polymerase IV; Validated; Region: PRK01810 412694011076 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 412694011077 active site 412694011078 DNA binding site [nucleotide binding] 412694011079 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 412694011080 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 412694011081 peptidase T-like protein; Region: PepT-like; TIGR01883 412694011082 metal binding site [ion binding]; metal-binding site 412694011083 putative dimer interface [polypeptide binding]; other site 412694011084 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 412694011085 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 412694011086 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 412694011087 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 412694011088 Predicted membrane protein [Function unknown]; Region: COG4129 412694011089 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 412694011090 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 412694011091 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 412694011092 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 412694011093 Walker A/P-loop; other site 412694011094 ATP binding site [chemical binding]; other site 412694011095 Q-loop/lid; other site 412694011096 ABC transporter signature motif; other site 412694011097 Walker B; other site 412694011098 D-loop; other site 412694011099 H-loop/switch region; other site 412694011100 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 412694011101 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694011102 dimer interface [polypeptide binding]; other site 412694011103 conserved gate region; other site 412694011104 putative PBP binding loops; other site 412694011105 ABC-ATPase subunit interface; other site 412694011106 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 412694011107 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 412694011108 substrate binding pocket [chemical binding]; other site 412694011109 membrane-bound complex binding site; other site 412694011110 hinge residues; other site 412694011111 Disulphide isomerase; Region: Disulph_isomer; pfam06491 412694011112 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 412694011113 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 412694011114 nudix motif; other site 412694011115 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 412694011116 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 412694011117 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 412694011118 E3 interaction surface; other site 412694011119 lipoyl attachment site [posttranslational modification]; other site 412694011120 e3 binding domain; Region: E3_binding; pfam02817 412694011121 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 412694011122 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 412694011123 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 412694011124 alpha subunit interface [polypeptide binding]; other site 412694011125 TPP binding site [chemical binding]; other site 412694011126 heterodimer interface [polypeptide binding]; other site 412694011127 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 412694011128 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 412694011129 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 412694011130 tetramer interface [polypeptide binding]; other site 412694011131 TPP-binding site [chemical binding]; other site 412694011132 heterodimer interface [polypeptide binding]; other site 412694011133 phosphorylation loop region [posttranslational modification] 412694011134 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 412694011135 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 412694011136 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 412694011137 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 412694011138 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 412694011139 nucleotide binding site [chemical binding]; other site 412694011140 Acetokinase family; Region: Acetate_kinase; cl17229 412694011141 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 412694011142 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 412694011143 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 412694011144 NAD binding site [chemical binding]; other site 412694011145 Phe binding site; other site 412694011146 phosphate butyryltransferase; Validated; Region: PRK07742 412694011147 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 412694011148 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 412694011149 putative active site [active] 412694011150 heme pocket [chemical binding]; other site 412694011151 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 412694011152 putative active site [active] 412694011153 heme pocket [chemical binding]; other site 412694011154 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412694011155 Walker A motif; other site 412694011156 ATP binding site [chemical binding]; other site 412694011157 Walker B motif; other site 412694011158 arginine finger; other site 412694011159 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 412694011160 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 412694011161 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 412694011162 active site 412694011163 catalytic site [active] 412694011164 metal binding site [ion binding]; metal-binding site 412694011165 dimer interface [polypeptide binding]; other site 412694011166 conserved hypothetical integral membrane protein; Region: TIGR03766 412694011167 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 412694011168 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694011169 active site 412694011170 phosphorylation site [posttranslational modification] 412694011171 intermolecular recognition site; other site 412694011172 dimerization interface [polypeptide binding]; other site 412694011173 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 412694011174 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 412694011175 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 412694011176 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 412694011177 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 412694011178 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 412694011179 Walker A/P-loop; other site 412694011180 ATP binding site [chemical binding]; other site 412694011181 Q-loop/lid; other site 412694011182 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 412694011183 ABC transporter signature motif; other site 412694011184 Walker B; other site 412694011185 D-loop; other site 412694011186 H-loop/switch region; other site 412694011187 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 412694011188 arginine repressor; Provisional; Region: PRK04280 412694011189 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 412694011190 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 412694011191 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 412694011192 RNA binding surface [nucleotide binding]; other site 412694011193 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 412694011194 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 412694011195 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 412694011196 TPP-binding site; other site 412694011197 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 412694011198 PYR/PP interface [polypeptide binding]; other site 412694011199 dimer interface [polypeptide binding]; other site 412694011200 TPP binding site [chemical binding]; other site 412694011201 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 412694011202 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 412694011203 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 412694011204 substrate binding pocket [chemical binding]; other site 412694011205 chain length determination region; other site 412694011206 substrate-Mg2+ binding site; other site 412694011207 catalytic residues [active] 412694011208 aspartate-rich region 1; other site 412694011209 active site lid residues [active] 412694011210 aspartate-rich region 2; other site 412694011211 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 412694011212 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 412694011213 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 412694011214 generic binding surface II; other site 412694011215 generic binding surface I; other site 412694011216 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 412694011217 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 412694011218 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 412694011219 homodimer interface [polypeptide binding]; other site 412694011220 NADP binding site [chemical binding]; other site 412694011221 substrate binding site [chemical binding]; other site 412694011222 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 412694011223 putative RNA binding site [nucleotide binding]; other site 412694011224 Asp23 family; Region: Asp23; pfam03780 412694011225 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 412694011226 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 412694011227 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 412694011228 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 412694011229 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 412694011230 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 412694011231 carboxyltransferase (CT) interaction site; other site 412694011232 biotinylation site [posttranslational modification]; other site 412694011233 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 412694011234 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 412694011235 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 412694011236 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 412694011237 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 412694011238 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 412694011239 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 412694011240 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 412694011241 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412694011242 Walker A motif; other site 412694011243 ATP binding site [chemical binding]; other site 412694011244 Walker B motif; other site 412694011245 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 412694011246 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 412694011247 elongation factor P; Validated; Region: PRK00529 412694011248 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 412694011249 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 412694011250 RNA binding site [nucleotide binding]; other site 412694011251 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 412694011252 RNA binding site [nucleotide binding]; other site 412694011253 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 412694011254 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 412694011255 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 412694011256 active site 412694011257 Dehydroquinase class II; Region: DHquinase_II; pfam01220 412694011258 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 412694011259 trimer interface [polypeptide binding]; other site 412694011260 active site 412694011261 dimer interface [polypeptide binding]; other site 412694011262 Conserved membrane protein YqhR; Region: YqhR; pfam11085 412694011263 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 412694011264 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 412694011265 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 412694011266 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412694011267 motif II; other site 412694011268 manganese transport transcriptional regulator; Provisional; Region: PRK03902 412694011269 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 412694011270 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 412694011271 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 412694011272 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412694011273 FeS/SAM binding site; other site 412694011274 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 412694011275 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 412694011276 active site residue [active] 412694011277 Transcriptional regulators [Transcription]; Region: PurR; COG1609 412694011278 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 412694011279 DNA binding site [nucleotide binding] 412694011280 domain linker motif; other site 412694011281 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 412694011282 putative dimerization interface [polypeptide binding]; other site 412694011283 putative ligand binding site [chemical binding]; other site 412694011284 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412694011285 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412694011286 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 412694011287 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 412694011288 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 412694011289 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 412694011290 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 412694011291 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 412694011292 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 412694011293 Walker A/P-loop; other site 412694011294 ATP binding site [chemical binding]; other site 412694011295 Q-loop/lid; other site 412694011296 ABC transporter signature motif; other site 412694011297 Walker B; other site 412694011298 D-loop; other site 412694011299 H-loop/switch region; other site 412694011300 Predicted transcriptional regulators [Transcription]; Region: COG1725 412694011301 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412694011302 DNA-binding site [nucleotide binding]; DNA binding site 412694011303 Protein of unknown function (DUF3929); Region: DUF3929; pfam13066 412694011304 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 412694011305 tetramer interface [polypeptide binding]; other site 412694011306 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694011307 catalytic residue [active] 412694011308 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 412694011309 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 412694011310 tetramer interface [polypeptide binding]; other site 412694011311 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694011312 catalytic residue [active] 412694011313 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 412694011314 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 412694011315 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 412694011316 DEAD-like helicases superfamily; Region: DEXDc; smart00487 412694011317 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 412694011318 ATP binding site [chemical binding]; other site 412694011319 putative Mg++ binding site [ion binding]; other site 412694011320 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412694011321 nucleotide binding region [chemical binding]; other site 412694011322 ATP-binding site [chemical binding]; other site 412694011323 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 412694011324 YqzE-like protein; Region: YqzE; pfam14038 412694011325 shikimate kinase; Reviewed; Region: aroK; PRK00131 412694011326 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 412694011327 ADP binding site [chemical binding]; other site 412694011328 magnesium binding site [ion binding]; other site 412694011329 putative shikimate binding site; other site 412694011330 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 412694011331 ComG operon protein 7; Region: ComGG; pfam14173 412694011332 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 412694011333 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 412694011334 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 412694011335 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 412694011336 Type II/IV secretion system protein; Region: T2SE; pfam00437 412694011337 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 412694011338 Walker A motif; other site 412694011339 ATP binding site [chemical binding]; other site 412694011340 Walker B motif; other site 412694011341 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412694011342 putative DNA binding site [nucleotide binding]; other site 412694011343 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 412694011344 putative Zn2+ binding site [ion binding]; other site 412694011345 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 412694011346 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 412694011347 Protein of unknown function (DUF3912); Region: DUF3912; pfam13051 412694011348 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 412694011349 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 412694011350 Protein of unknown function (DUF3966); Region: DUF3966; pfam13110 412694011351 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 412694011352 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 412694011353 active site 412694011354 homodimer interface [polypeptide binding]; other site 412694011355 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 412694011356 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 412694011357 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 412694011358 substrate binding pocket [chemical binding]; other site 412694011359 dimer interface [polypeptide binding]; other site 412694011360 inhibitor binding site; inhibition site 412694011361 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 412694011362 B12 binding site [chemical binding]; other site 412694011363 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 412694011364 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 412694011365 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 412694011366 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 412694011367 FAD binding site [chemical binding]; other site 412694011368 cystathionine gamma-synthase; Reviewed; Region: PRK08247 412694011369 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 412694011370 homodimer interface [polypeptide binding]; other site 412694011371 substrate-cofactor binding pocket; other site 412694011372 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694011373 catalytic residue [active] 412694011374 cystathionine beta-lyase; Provisional; Region: PRK08064 412694011375 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 412694011376 homodimer interface [polypeptide binding]; other site 412694011377 substrate-cofactor binding pocket; other site 412694011378 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694011379 catalytic residue [active] 412694011380 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412694011381 dimerization interface [polypeptide binding]; other site 412694011382 putative DNA binding site [nucleotide binding]; other site 412694011383 putative Zn2+ binding site [ion binding]; other site 412694011384 Uncharacterized conserved protein [Function unknown]; Region: COG1565 412694011385 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 412694011386 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 412694011387 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 412694011388 nucleotide binding site [chemical binding]; other site 412694011389 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 412694011390 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 412694011391 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 412694011392 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 412694011393 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 412694011394 active site 412694011395 Substrate binding site; other site 412694011396 Mg++ binding site; other site 412694011397 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 412694011398 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 412694011399 active site 412694011400 metal binding site [ion binding]; metal-binding site 412694011401 substrate binding site [chemical binding]; other site 412694011402 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 412694011403 PhoU domain; Region: PhoU; pfam01895 412694011404 PhoU domain; Region: PhoU; pfam01895 412694011405 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 412694011406 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 412694011407 Walker A/P-loop; other site 412694011408 ATP binding site [chemical binding]; other site 412694011409 Q-loop/lid; other site 412694011410 ABC transporter signature motif; other site 412694011411 Walker B; other site 412694011412 D-loop; other site 412694011413 H-loop/switch region; other site 412694011414 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 412694011415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694011416 dimer interface [polypeptide binding]; other site 412694011417 conserved gate region; other site 412694011418 putative PBP binding loops; other site 412694011419 ABC-ATPase subunit interface; other site 412694011420 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 412694011421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694011422 dimer interface [polypeptide binding]; other site 412694011423 conserved gate region; other site 412694011424 putative PBP binding loops; other site 412694011425 ABC-ATPase subunit interface; other site 412694011426 PBP superfamily domain; Region: PBP_like_2; cl17296 412694011427 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 412694011428 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 412694011429 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 412694011430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694011431 putative substrate translocation pore; other site 412694011432 Major Facilitator Superfamily; Region: MFS_1; pfam07690 412694011433 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 412694011434 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 412694011435 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 412694011436 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 412694011437 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 412694011438 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 412694011439 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 412694011440 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 412694011441 metal binding site 2 [ion binding]; metal-binding site 412694011442 putative DNA binding helix; other site 412694011443 metal binding site 1 [ion binding]; metal-binding site 412694011444 dimer interface [polypeptide binding]; other site 412694011445 structural Zn2+ binding site [ion binding]; other site 412694011446 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 412694011447 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 412694011448 ABC-ATPase subunit interface; other site 412694011449 dimer interface [polypeptide binding]; other site 412694011450 putative PBP binding regions; other site 412694011451 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 412694011452 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 412694011453 Uncharacterized conserved protein [Function unknown]; Region: COG1284 412694011454 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 412694011455 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 412694011456 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 412694011457 endonuclease IV; Provisional; Region: PRK01060 412694011458 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 412694011459 AP (apurinic/apyrimidinic) site pocket; other site 412694011460 DNA interaction; other site 412694011461 Metal-binding active site; metal-binding site 412694011462 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 412694011463 DEAD-like helicases superfamily; Region: DEXDc; smart00487 412694011464 ATP binding site [chemical binding]; other site 412694011465 Mg++ binding site [ion binding]; other site 412694011466 motif III; other site 412694011467 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412694011468 nucleotide binding region [chemical binding]; other site 412694011469 ATP-binding site [chemical binding]; other site 412694011470 YqfQ-like protein; Region: YqfQ; pfam14181 412694011471 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 412694011472 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 412694011473 Uncharacterized conserved protein [Function unknown]; Region: COG0327 412694011474 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 412694011475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 412694011476 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 412694011477 Uncharacterized conserved protein [Function unknown]; Region: COG0327 412694011478 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 412694011479 Family of unknown function (DUF633); Region: DUF633; pfam04816 412694011480 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 412694011481 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 412694011482 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 412694011483 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 412694011484 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 412694011485 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412694011486 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 412694011487 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 412694011488 DNA binding residues [nucleotide binding] 412694011489 DNA primase; Validated; Region: dnaG; PRK05667 412694011490 CHC2 zinc finger; Region: zf-CHC2; pfam01807 412694011491 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 412694011492 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 412694011493 active site 412694011494 metal binding site [ion binding]; metal-binding site 412694011495 interdomain interaction site; other site 412694011496 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 412694011497 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 412694011498 PEP synthetase regulatory protein; Provisional; Region: PRK05339 412694011499 HTH domain; Region: HTH_11; pfam08279 412694011500 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 412694011501 FOG: CBS domain [General function prediction only]; Region: COG0517 412694011502 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 412694011503 Recombination protein O N terminal; Region: RecO_N; pfam11967 412694011504 Recombination protein O C terminal; Region: RecO_C; pfam02565 412694011505 GTPase Era; Reviewed; Region: era; PRK00089 412694011506 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 412694011507 G1 box; other site 412694011508 GTP/Mg2+ binding site [chemical binding]; other site 412694011509 Switch I region; other site 412694011510 G2 box; other site 412694011511 Switch II region; other site 412694011512 G3 box; other site 412694011513 G4 box; other site 412694011514 G5 box; other site 412694011515 KH domain; Region: KH_2; pfam07650 412694011516 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 412694011517 active site 412694011518 catalytic motif [active] 412694011519 Zn binding site [ion binding]; other site 412694011520 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 412694011521 metal-binding heat shock protein; Provisional; Region: PRK00016 412694011522 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 412694011523 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 412694011524 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 412694011525 Zn2+ binding site [ion binding]; other site 412694011526 Mg2+ binding site [ion binding]; other site 412694011527 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 412694011528 PhoH-like protein; Region: PhoH; pfam02562 412694011529 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 412694011530 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 412694011531 Yqey-like protein; Region: YqeY; pfam09424 412694011532 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 412694011533 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 412694011534 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 412694011535 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412694011536 FeS/SAM binding site; other site 412694011537 TRAM domain; Region: TRAM; cl01282 412694011538 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 412694011539 RNA methyltransferase, RsmE family; Region: TIGR00046 412694011540 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 412694011541 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694011542 S-adenosylmethionine binding site [chemical binding]; other site 412694011543 chaperone protein DnaJ; Provisional; Region: PRK14280 412694011544 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 412694011545 HSP70 interaction site [polypeptide binding]; other site 412694011546 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 412694011547 substrate binding site [polypeptide binding]; other site 412694011548 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 412694011549 Zn binding sites [ion binding]; other site 412694011550 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 412694011551 dimer interface [polypeptide binding]; other site 412694011552 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 412694011553 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 412694011554 nucleotide binding site [chemical binding]; other site 412694011555 NEF interaction site [polypeptide binding]; other site 412694011556 SBD interface [polypeptide binding]; other site 412694011557 GrpE; Region: GrpE; pfam01025 412694011558 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 412694011559 dimer interface [polypeptide binding]; other site 412694011560 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 412694011561 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 412694011562 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 412694011563 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 412694011564 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412694011565 FeS/SAM binding site; other site 412694011566 HemN C-terminal domain; Region: HemN_C; pfam06969 412694011567 GTP-binding protein LepA; Provisional; Region: PRK05433 412694011568 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 412694011569 G1 box; other site 412694011570 putative GEF interaction site [polypeptide binding]; other site 412694011571 GTP/Mg2+ binding site [chemical binding]; other site 412694011572 Switch I region; other site 412694011573 G2 box; other site 412694011574 G3 box; other site 412694011575 Switch II region; other site 412694011576 G4 box; other site 412694011577 G5 box; other site 412694011578 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 412694011579 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 412694011580 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 412694011581 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 412694011582 germination protease; Provisional; Region: PRK02858 412694011583 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 412694011584 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 412694011585 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 412694011586 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 412694011587 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 412694011588 Competence protein; Region: Competence; pfam03772 412694011589 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 412694011590 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 412694011591 catalytic motif [active] 412694011592 Zn binding site [ion binding]; other site 412694011593 SLBB domain; Region: SLBB; pfam10531 412694011594 comEA protein; Region: comE; TIGR01259 412694011595 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 412694011596 late competence protein ComER; Validated; Region: PRK07680 412694011597 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 412694011598 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 412694011599 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694011600 S-adenosylmethionine binding site [chemical binding]; other site 412694011601 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 412694011602 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 412694011603 Zn2+ binding site [ion binding]; other site 412694011604 Mg2+ binding site [ion binding]; other site 412694011605 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 412694011606 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 412694011607 active site 412694011608 (T/H)XGH motif; other site 412694011609 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 412694011610 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 412694011611 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 412694011612 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 412694011613 shikimate binding site; other site 412694011614 NAD(P) binding site [chemical binding]; other site 412694011615 GTPase YqeH; Provisional; Region: PRK13796 412694011616 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 412694011617 GTP/Mg2+ binding site [chemical binding]; other site 412694011618 G4 box; other site 412694011619 G5 box; other site 412694011620 G1 box; other site 412694011621 Switch I region; other site 412694011622 G2 box; other site 412694011623 G3 box; other site 412694011624 Switch II region; other site 412694011625 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 412694011626 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412694011627 active site 412694011628 motif I; other site 412694011629 motif II; other site 412694011630 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 412694011631 sporulation sigma factor SigK; Reviewed; Region: PRK05803 412694011632 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412694011633 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 412694011634 DNA binding residues [nucleotide binding] 412694011635 HTH-like domain; Region: HTH_21; pfam13276 412694011636 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 412694011637 Integrase core domain; Region: rve; pfam00665 412694011638 Integrase core domain; Region: rve_2; pfam13333 412694011639 Transposase; Region: HTH_Tnp_1; pfam01527 412694011640 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 412694011641 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 412694011642 dimer interface [polypeptide binding]; other site 412694011643 FMN binding site [chemical binding]; other site 412694011644 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 412694011645 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 412694011646 synthetase active site [active] 412694011647 NTP binding site [chemical binding]; other site 412694011648 metal binding site [ion binding]; metal-binding site 412694011649 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 412694011650 dimer interface [polypeptide binding]; other site 412694011651 Alkaline phosphatase homologues; Region: alkPPc; smart00098 412694011652 active site 412694011653 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694011654 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 412694011655 Coenzyme A binding pocket [chemical binding]; other site 412694011656 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 412694011657 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 412694011658 CHAT domain; Region: CHAT; cl17868 412694011659 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 412694011660 catalytic core [active] 412694011661 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 412694011662 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 412694011663 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 412694011664 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 412694011665 putative active site [active] 412694011666 catalytic triad [active] 412694011667 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 412694011668 putative integrin binding motif; other site 412694011669 PA/protease domain interface [polypeptide binding]; other site 412694011670 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 412694011671 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 412694011672 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 412694011673 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 412694011674 cofactor binding site; other site 412694011675 metal binding site [ion binding]; metal-binding site 412694011676 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 412694011677 aromatic arch; other site 412694011678 DCoH dimer interaction site [polypeptide binding]; other site 412694011679 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 412694011680 DCoH tetramer interaction site [polypeptide binding]; other site 412694011681 substrate binding site [chemical binding]; other site 412694011682 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 412694011683 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 412694011684 putative metal binding site [ion binding]; other site 412694011685 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 412694011686 active site 412694011687 metal binding site [ion binding]; metal-binding site 412694011688 Predicted membrane protein [Function unknown]; Region: COG2259 412694011689 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 412694011690 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412694011691 non-specific DNA binding site [nucleotide binding]; other site 412694011692 salt bridge; other site 412694011693 sequence-specific DNA binding site [nucleotide binding]; other site 412694011694 Cupin domain; Region: Cupin_2; pfam07883 412694011695 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 412694011696 active site 2 [active] 412694011697 active site 1 [active] 412694011698 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694011699 Coenzyme A binding pocket [chemical binding]; other site 412694011700 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 412694011701 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 412694011702 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 412694011703 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 412694011704 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 412694011705 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 412694011706 Walker A/P-loop; other site 412694011707 ATP binding site [chemical binding]; other site 412694011708 Q-loop/lid; other site 412694011709 ABC transporter signature motif; other site 412694011710 Walker B; other site 412694011711 D-loop; other site 412694011712 H-loop/switch region; other site 412694011713 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 412694011714 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 412694011715 ABC-ATPase subunit interface; other site 412694011716 dimer interface [polypeptide binding]; other site 412694011717 putative PBP binding regions; other site 412694011718 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 412694011719 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 412694011720 intersubunit interface [polypeptide binding]; other site 412694011721 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 412694011722 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 412694011723 putative catalytic cysteine [active] 412694011724 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 412694011725 putative active site [active] 412694011726 metal binding site [ion binding]; metal-binding site 412694011727 cystathionine beta-lyase; Provisional; Region: PRK07671 412694011728 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 412694011729 homodimer interface [polypeptide binding]; other site 412694011730 substrate-cofactor binding pocket; other site 412694011731 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694011732 catalytic residue [active] 412694011733 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 412694011734 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 412694011735 dimer interface [polypeptide binding]; other site 412694011736 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694011737 catalytic residue [active] 412694011738 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 412694011739 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 412694011740 Methyltransferase domain; Region: Methyltransf_23; pfam13489 412694011741 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694011742 S-adenosylmethionine binding site [chemical binding]; other site 412694011743 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 412694011744 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 412694011745 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 412694011746 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 412694011747 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 412694011748 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 412694011749 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 412694011750 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 412694011751 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 412694011752 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 412694011753 ATP-binding site [chemical binding]; other site 412694011754 Sugar specificity; other site 412694011755 Pyrimidine base specificity; other site 412694011756 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 412694011757 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 412694011758 Peptidase family U32; Region: Peptidase_U32; pfam01136 412694011759 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 412694011760 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 412694011761 Peptidase family U32; Region: Peptidase_U32; pfam01136 412694011762 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 412694011763 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694011764 S-adenosylmethionine binding site [chemical binding]; other site 412694011765 YceG-like family; Region: YceG; pfam02618 412694011766 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 412694011767 dimerization interface [polypeptide binding]; other site 412694011768 hypothetical protein; Provisional; Region: PRK13678 412694011769 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 412694011770 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 412694011771 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 412694011772 motif 1; other site 412694011773 active site 412694011774 motif 2; other site 412694011775 motif 3; other site 412694011776 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 412694011777 DHHA1 domain; Region: DHHA1; pfam02272 412694011778 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 412694011779 Domain of unknown function DUF20; Region: UPF0118; pfam01594 412694011780 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 412694011781 AAA domain; Region: AAA_30; pfam13604 412694011782 Family description; Region: UvrD_C_2; pfam13538 412694011783 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412694011784 TPR motif; other site 412694011785 TPR repeat; Region: TPR_11; pfam13414 412694011786 binding surface 412694011787 TPR repeat; Region: TPR_11; pfam13414 412694011788 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412694011789 binding surface 412694011790 TPR motif; other site 412694011791 TPR repeat; Region: TPR_11; pfam13414 412694011792 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 412694011793 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 412694011794 Ligand Binding Site [chemical binding]; other site 412694011795 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 412694011796 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 412694011797 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412694011798 catalytic residue [active] 412694011799 Predicted transcriptional regulator [Transcription]; Region: COG1959 412694011800 Transcriptional regulator; Region: Rrf2; pfam02082 412694011801 recombination factor protein RarA; Reviewed; Region: PRK13342 412694011802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412694011803 Walker A motif; other site 412694011804 ATP binding site [chemical binding]; other site 412694011805 Walker B motif; other site 412694011806 arginine finger; other site 412694011807 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 412694011808 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 412694011809 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 412694011810 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 412694011811 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 412694011812 putative ATP binding site [chemical binding]; other site 412694011813 putative substrate interface [chemical binding]; other site 412694011814 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 412694011815 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 412694011816 dimer interface [polypeptide binding]; other site 412694011817 anticodon binding site; other site 412694011818 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 412694011819 homodimer interface [polypeptide binding]; other site 412694011820 motif 1; other site 412694011821 active site 412694011822 motif 2; other site 412694011823 GAD domain; Region: GAD; pfam02938 412694011824 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 412694011825 motif 3; other site 412694011826 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 412694011827 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 412694011828 dimer interface [polypeptide binding]; other site 412694011829 motif 1; other site 412694011830 active site 412694011831 motif 2; other site 412694011832 motif 3; other site 412694011833 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 412694011834 anticodon binding site; other site 412694011835 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 412694011836 putative active site [active] 412694011837 dimerization interface [polypeptide binding]; other site 412694011838 putative tRNAtyr binding site [nucleotide binding]; other site 412694011839 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 412694011840 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 412694011841 Zn2+ binding site [ion binding]; other site 412694011842 Mg2+ binding site [ion binding]; other site 412694011843 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 412694011844 synthetase active site [active] 412694011845 NTP binding site [chemical binding]; other site 412694011846 metal binding site [ion binding]; metal-binding site 412694011847 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 412694011848 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 412694011849 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 412694011850 active site 412694011851 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 412694011852 DHH family; Region: DHH; pfam01368 412694011853 DHHA1 domain; Region: DHHA1; pfam02272 412694011854 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 412694011855 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 412694011856 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 412694011857 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 412694011858 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 412694011859 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 412694011860 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 412694011861 Protein export membrane protein; Region: SecD_SecF; pfam02355 412694011862 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 412694011863 stage V sporulation protein B; Region: spore_V_B; TIGR02900 412694011864 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 412694011865 Predicted membrane protein [Function unknown]; Region: COG2323 412694011866 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 412694011867 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 412694011868 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 412694011869 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 412694011870 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 412694011871 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 412694011872 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412694011873 Walker A motif; other site 412694011874 ATP binding site [chemical binding]; other site 412694011875 Walker B motif; other site 412694011876 arginine finger; other site 412694011877 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 412694011878 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 412694011879 RuvA N terminal domain; Region: RuvA_N; pfam01330 412694011880 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 412694011881 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 412694011882 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 412694011883 putative ligand binding residues [chemical binding]; other site 412694011884 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 412694011885 BofC C-terminal domain; Region: BofC_C; pfam08955 412694011886 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 412694011887 EamA-like transporter family; Region: EamA; pfam00892 412694011888 EamA-like transporter family; Region: EamA; pfam00892 412694011889 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412694011890 dimerization interface [polypeptide binding]; other site 412694011891 putative DNA binding site [nucleotide binding]; other site 412694011892 putative Zn2+ binding site [ion binding]; other site 412694011893 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 412694011894 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 412694011895 quinolinate synthetase; Provisional; Region: PRK09375 412694011896 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 412694011897 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 412694011898 dimerization interface [polypeptide binding]; other site 412694011899 active site 412694011900 L-aspartate oxidase; Provisional; Region: PRK08071 412694011901 L-aspartate oxidase; Provisional; Region: PRK06175 412694011902 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 412694011903 cysteine desulfurase; Provisional; Region: PRK02948 412694011904 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 412694011905 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412694011906 catalytic residue [active] 412694011907 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 412694011908 HTH domain; Region: HTH_11; pfam08279 412694011909 3H domain; Region: 3H; pfam02829 412694011910 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 412694011911 MOSC domain; Region: MOSC; pfam03473 412694011912 3-alpha domain; Region: 3-alpha; pfam03475 412694011913 prephenate dehydratase; Provisional; Region: PRK11898 412694011914 Prephenate dehydratase; Region: PDT; pfam00800 412694011915 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 412694011916 putative L-Phe binding site [chemical binding]; other site 412694011917 FtsX-like permease family; Region: FtsX; pfam02687 412694011918 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 412694011919 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 412694011920 FtsX-like permease family; Region: FtsX; pfam02687 412694011921 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 412694011922 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 412694011923 Walker A/P-loop; other site 412694011924 ATP binding site [chemical binding]; other site 412694011925 Q-loop/lid; other site 412694011926 ABC transporter signature motif; other site 412694011927 Walker B; other site 412694011928 D-loop; other site 412694011929 H-loop/switch region; other site 412694011930 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412694011931 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 412694011932 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694011933 ATP binding site [chemical binding]; other site 412694011934 Mg2+ binding site [ion binding]; other site 412694011935 G-X-G motif; other site 412694011936 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412694011937 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694011938 active site 412694011939 phosphorylation site [posttranslational modification] 412694011940 intermolecular recognition site; other site 412694011941 dimerization interface [polypeptide binding]; other site 412694011942 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412694011943 DNA binding site [nucleotide binding] 412694011944 GTPase CgtA; Reviewed; Region: obgE; PRK12297 412694011945 GTP1/OBG; Region: GTP1_OBG; pfam01018 412694011946 Obg GTPase; Region: Obg; cd01898 412694011947 G1 box; other site 412694011948 GTP/Mg2+ binding site [chemical binding]; other site 412694011949 Switch I region; other site 412694011950 G2 box; other site 412694011951 G3 box; other site 412694011952 Switch II region; other site 412694011953 G4 box; other site 412694011954 G5 box; other site 412694011955 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 412694011956 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 412694011957 hypothetical protein; Provisional; Region: PRK14553 412694011958 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 412694011959 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 412694011960 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 412694011961 homodimer interface [polypeptide binding]; other site 412694011962 oligonucleotide binding site [chemical binding]; other site 412694011963 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 412694011964 Peptidase family M50; Region: Peptidase_M50; pfam02163 412694011965 active site 412694011966 putative substrate binding region [chemical binding]; other site 412694011967 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 412694011968 Peptidase family M23; Region: Peptidase_M23; pfam01551 412694011969 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 412694011970 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 412694011971 Switch I; other site 412694011972 Switch II; other site 412694011973 septum formation inhibitor; Reviewed; Region: minC; PRK00513 412694011974 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 412694011975 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 412694011976 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 412694011977 rod shape-determining protein MreC; Region: MreC; pfam04085 412694011978 rod shape-determining protein MreB; Provisional; Region: PRK13927 412694011979 MreB and similar proteins; Region: MreB_like; cd10225 412694011980 nucleotide binding site [chemical binding]; other site 412694011981 Mg binding site [ion binding]; other site 412694011982 putative protofilament interaction site [polypeptide binding]; other site 412694011983 RodZ interaction site [polypeptide binding]; other site 412694011984 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 412694011985 active site 412694011986 Int/Topo IB signature motif; other site 412694011987 DNA binding site [nucleotide binding] 412694011988 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 412694011989 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 412694011990 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 412694011991 HlyD family secretion protein; Region: HlyD_3; pfam13437 412694011992 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 412694011993 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 412694011994 putative active site [active] 412694011995 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 412694011996 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412694011997 Walker A/P-loop; other site 412694011998 ATP binding site [chemical binding]; other site 412694011999 Q-loop/lid; other site 412694012000 ABC transporter signature motif; other site 412694012001 Walker B; other site 412694012002 D-loop; other site 412694012003 H-loop/switch region; other site 412694012004 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694012005 hypothetical protein; Reviewed; Region: PRK00024 412694012006 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 412694012007 MPN+ (JAMM) motif; other site 412694012008 Zinc-binding site [ion binding]; other site 412694012009 Maf-like protein; Region: Maf; pfam02545 412694012010 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 412694012011 active site 412694012012 dimer interface [polypeptide binding]; other site 412694012013 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 412694012014 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 412694012015 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 412694012016 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 412694012017 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 412694012018 active site 412694012019 HIGH motif; other site 412694012020 nucleotide binding site [chemical binding]; other site 412694012021 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 412694012022 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 412694012023 active site 412694012024 KMSKS motif; other site 412694012025 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 412694012026 tRNA binding surface [nucleotide binding]; other site 412694012027 anticodon binding site; other site 412694012028 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 412694012029 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 412694012030 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 412694012031 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 412694012032 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 412694012033 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 412694012034 inhibitor-cofactor binding pocket; inhibition site 412694012035 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694012036 catalytic residue [active] 412694012037 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 412694012038 dimer interface [polypeptide binding]; other site 412694012039 active site 412694012040 Schiff base residues; other site 412694012041 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 412694012042 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 412694012043 active site 412694012044 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 412694012045 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 412694012046 domain interfaces; other site 412694012047 active site 412694012048 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 412694012049 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 412694012050 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 412694012051 tRNA; other site 412694012052 putative tRNA binding site [nucleotide binding]; other site 412694012053 putative NADP binding site [chemical binding]; other site 412694012054 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 412694012055 Transcriptional regulators [Transcription]; Region: MarR; COG1846 412694012056 MarR family; Region: MarR; pfam01047 412694012057 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 412694012058 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 412694012059 G1 box; other site 412694012060 GTP/Mg2+ binding site [chemical binding]; other site 412694012061 Switch I region; other site 412694012062 G2 box; other site 412694012063 G3 box; other site 412694012064 Switch II region; other site 412694012065 G4 box; other site 412694012066 G5 box; other site 412694012067 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 412694012068 Found in ATP-dependent protease La (LON); Region: LON; smart00464 412694012069 Found in ATP-dependent protease La (LON); Region: LON; smart00464 412694012070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412694012071 Walker A motif; other site 412694012072 ATP binding site [chemical binding]; other site 412694012073 Walker B motif; other site 412694012074 arginine finger; other site 412694012075 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 412694012076 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 412694012077 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412694012078 Walker A motif; other site 412694012079 ATP binding site [chemical binding]; other site 412694012080 Walker B motif; other site 412694012081 arginine finger; other site 412694012082 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 412694012083 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 412694012084 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 412694012085 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412694012086 Walker A motif; other site 412694012087 ATP binding site [chemical binding]; other site 412694012088 Walker B motif; other site 412694012089 arginine finger; other site 412694012090 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 412694012091 trigger factor; Provisional; Region: tig; PRK01490 412694012092 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 412694012093 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 412694012094 Protein of unknown function (DUF3257); Region: DUF3257; pfam11645 412694012095 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 412694012096 pentamer interface [polypeptide binding]; other site 412694012097 dodecaamer interface [polypeptide binding]; other site 412694012098 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 412694012099 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 412694012100 active site 412694012101 metal binding site [ion binding]; metal-binding site 412694012102 homotetramer interface [polypeptide binding]; other site 412694012103 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 412694012104 active site 412694012105 dimerization interface [polypeptide binding]; other site 412694012106 ribonuclease PH; Reviewed; Region: rph; PRK00173 412694012107 Ribonuclease PH; Region: RNase_PH_bact; cd11362 412694012108 hexamer interface [polypeptide binding]; other site 412694012109 active site 412694012110 Sporulation and spore germination; Region: Germane; pfam10646 412694012111 Spore germination protein [General function prediction only]; Region: COG5401 412694012112 Sporulation and spore germination; Region: Germane; pfam10646 412694012113 glutamate racemase; Provisional; Region: PRK00865 412694012114 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 412694012115 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 412694012116 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 412694012117 potential catalytic triad [active] 412694012118 conserved cys residue [active] 412694012119 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412694012120 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412694012121 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 412694012122 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 412694012123 potential catalytic triad [active] 412694012124 conserved cys residue [active] 412694012125 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 412694012126 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 412694012127 DNA binding residues [nucleotide binding] 412694012128 dimerization interface [polypeptide binding]; other site 412694012129 putative uracil/xanthine transporter; Provisional; Region: PRK11412 412694012130 putative deaminase; Validated; Region: PRK06846 412694012131 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 412694012132 active site 412694012133 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 412694012134 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412694012135 non-specific DNA binding site [nucleotide binding]; other site 412694012136 salt bridge; other site 412694012137 sequence-specific DNA binding site [nucleotide binding]; other site 412694012138 Cupin domain; Region: Cupin_2; pfam07883 412694012139 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 412694012140 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 412694012141 amphipathic channel; other site 412694012142 Asn-Pro-Ala signature motifs; other site 412694012143 Predicted transcriptional regulator [Transcription]; Region: COG1959 412694012144 Transcriptional regulator; Region: Rrf2; pfam02082 412694012145 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 412694012146 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 412694012147 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412694012148 Walker A/P-loop; other site 412694012149 ATP binding site [chemical binding]; other site 412694012150 Q-loop/lid; other site 412694012151 ABC transporter signature motif; other site 412694012152 Walker B; other site 412694012153 D-loop; other site 412694012154 H-loop/switch region; other site 412694012155 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 412694012156 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412694012157 active site 412694012158 motif I; other site 412694012159 motif II; other site 412694012160 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 412694012161 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 412694012162 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 412694012163 ligand binding site [chemical binding]; other site 412694012164 flagellar motor protein MotA; Validated; Region: PRK08124 412694012165 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 412694012166 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 412694012167 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 412694012168 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 412694012169 active site 412694012170 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 412694012171 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 412694012172 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 412694012173 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 412694012174 L-aspartate oxidase; Provisional; Region: PRK06175 412694012175 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 412694012176 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 412694012177 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 412694012178 putative Iron-sulfur protein interface [polypeptide binding]; other site 412694012179 proximal heme binding site [chemical binding]; other site 412694012180 distal heme binding site [chemical binding]; other site 412694012181 putative dimer interface [polypeptide binding]; other site 412694012182 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 412694012183 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 412694012184 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 412694012185 GIY-YIG motif/motif A; other site 412694012186 active site 412694012187 catalytic site [active] 412694012188 putative DNA binding site [nucleotide binding]; other site 412694012189 metal binding site [ion binding]; metal-binding site 412694012190 UvrB/uvrC motif; Region: UVR; pfam02151 412694012191 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 412694012192 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 412694012193 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 412694012194 catalytic residues [active] 412694012195 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 412694012196 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 412694012197 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 412694012198 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 412694012199 Ligand binding site [chemical binding]; other site 412694012200 Electron transfer flavoprotein domain; Region: ETF; pfam01012 412694012201 enoyl-CoA hydratase; Provisional; Region: PRK07658 412694012202 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 412694012203 substrate binding site [chemical binding]; other site 412694012204 oxyanion hole (OAH) forming residues; other site 412694012205 trimer interface [polypeptide binding]; other site 412694012206 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 412694012207 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412694012208 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412694012209 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 412694012210 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 412694012211 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 412694012212 acyl-activating enzyme (AAE) consensus motif; other site 412694012213 putative AMP binding site [chemical binding]; other site 412694012214 putative active site [active] 412694012215 putative CoA binding site [chemical binding]; other site 412694012216 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 412694012217 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 412694012218 siderophore binding site; other site 412694012219 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 412694012220 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 412694012221 ABC-ATPase subunit interface; other site 412694012222 dimer interface [polypeptide binding]; other site 412694012223 putative PBP binding regions; other site 412694012224 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 412694012225 ABC-ATPase subunit interface; other site 412694012226 dimer interface [polypeptide binding]; other site 412694012227 putative PBP binding regions; other site 412694012228 DinB family; Region: DinB; pfam05163 412694012229 DinB superfamily; Region: DinB_2; pfam12867 412694012230 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 412694012231 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 412694012232 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 412694012233 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 412694012234 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 412694012235 Walker A/P-loop; other site 412694012236 ATP binding site [chemical binding]; other site 412694012237 Q-loop/lid; other site 412694012238 ABC transporter signature motif; other site 412694012239 Walker B; other site 412694012240 D-loop; other site 412694012241 H-loop/switch region; other site 412694012242 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412694012243 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694012244 dimer interface [polypeptide binding]; other site 412694012245 phosphorylation site [posttranslational modification] 412694012246 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694012247 ATP binding site [chemical binding]; other site 412694012248 Mg2+ binding site [ion binding]; other site 412694012249 G-X-G motif; other site 412694012250 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412694012251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694012252 active site 412694012253 phosphorylation site [posttranslational modification] 412694012254 intermolecular recognition site; other site 412694012255 dimerization interface [polypeptide binding]; other site 412694012256 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412694012257 DNA binding site [nucleotide binding] 412694012258 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 412694012259 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 412694012260 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 412694012261 putative RNA binding site [nucleotide binding]; other site 412694012262 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 412694012263 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 412694012264 Neurotransmitter-gated ion-channel transmembrane region; Region: Neur_chan_memb; pfam02932 412694012265 TrkA-N domain; Region: TrkA_N; pfam02254 412694012266 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13314 412694012267 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 412694012268 active site 412694012269 catalytic site [active] 412694012270 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 412694012271 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 412694012272 Walker A/P-loop; other site 412694012273 ATP binding site [chemical binding]; other site 412694012274 Q-loop/lid; other site 412694012275 ABC transporter signature motif; other site 412694012276 Walker B; other site 412694012277 D-loop; other site 412694012278 H-loop/switch region; other site 412694012279 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 412694012280 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 412694012281 ABC-ATPase subunit interface; other site 412694012282 dimer interface [polypeptide binding]; other site 412694012283 putative PBP binding regions; other site 412694012284 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 412694012285 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 412694012286 intersubunit interface [polypeptide binding]; other site 412694012287 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 412694012288 heme-binding site [chemical binding]; other site 412694012289 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 412694012290 heme-binding site [chemical binding]; other site 412694012291 Repeat of unknown function (DUF1388); Region: DUF1388; pfam07142 412694012292 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 412694012293 heme-binding site [chemical binding]; other site 412694012294 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 412694012295 heme-binding site [chemical binding]; other site 412694012296 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 412694012297 heme-binding site [chemical binding]; other site 412694012298 heme uptake protein IsdC; Region: IsdC; TIGR03656 412694012299 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 412694012300 heme-binding site [chemical binding]; other site 412694012301 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 412694012302 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 412694012303 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 412694012304 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 412694012305 RNA binding surface [nucleotide binding]; other site 412694012306 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 412694012307 probable active site [active] 412694012308 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 412694012309 MutS domain III; Region: MutS_III; pfam05192 412694012310 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 412694012311 Walker A/P-loop; other site 412694012312 ATP binding site [chemical binding]; other site 412694012313 Q-loop/lid; other site 412694012314 ABC transporter signature motif; other site 412694012315 Walker B; other site 412694012316 D-loop; other site 412694012317 H-loop/switch region; other site 412694012318 Smr domain; Region: Smr; pfam01713 412694012319 hypothetical protein; Provisional; Region: PRK08609 412694012320 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 412694012321 active site 412694012322 primer binding site [nucleotide binding]; other site 412694012323 NTP binding site [chemical binding]; other site 412694012324 metal binding triad [ion binding]; metal-binding site 412694012325 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 412694012326 active site 412694012327 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 412694012328 Colicin V production protein; Region: Colicin_V; pfam02674 412694012329 cell division protein ZapA; Provisional; Region: PRK14126 412694012330 ribonuclease HIII; Provisional; Region: PRK00996 412694012331 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 412694012332 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 412694012333 RNA/DNA hybrid binding site [nucleotide binding]; other site 412694012334 active site 412694012335 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 412694012336 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 412694012337 putative dimer interface [polypeptide binding]; other site 412694012338 putative anticodon binding site; other site 412694012339 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 412694012340 homodimer interface [polypeptide binding]; other site 412694012341 motif 1; other site 412694012342 motif 2; other site 412694012343 active site 412694012344 motif 3; other site 412694012345 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 412694012346 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 412694012347 putative tRNA-binding site [nucleotide binding]; other site 412694012348 B3/4 domain; Region: B3_4; pfam03483 412694012349 tRNA synthetase B5 domain; Region: B5; smart00874 412694012350 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 412694012351 dimer interface [polypeptide binding]; other site 412694012352 motif 1; other site 412694012353 motif 3; other site 412694012354 motif 2; other site 412694012355 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 412694012356 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 412694012357 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 412694012358 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 412694012359 dimer interface [polypeptide binding]; other site 412694012360 motif 1; other site 412694012361 active site 412694012362 motif 2; other site 412694012363 motif 3; other site 412694012364 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 412694012365 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 412694012366 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 412694012367 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 412694012368 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 412694012369 Zn2+ binding site [ion binding]; other site 412694012370 Mg2+ binding site [ion binding]; other site 412694012371 CAAX protease self-immunity; Region: Abi; pfam02517 412694012372 CAAX protease self-immunity; Region: Abi; pfam02517 412694012373 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 412694012374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694012375 putative substrate translocation pore; other site 412694012376 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694012377 HlyD family secretion protein; Region: HlyD_3; pfam13437 412694012378 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412694012379 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412694012380 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 412694012381 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 412694012382 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 412694012383 oligomer interface [polypeptide binding]; other site 412694012384 active site 412694012385 metal binding site [ion binding]; metal-binding site 412694012386 dUTPase; Region: dUTPase_2; pfam08761 412694012387 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 412694012388 active site 412694012389 homodimer interface [polypeptide binding]; other site 412694012390 metal binding site [ion binding]; metal-binding site 412694012391 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 412694012392 23S rRNA binding site [nucleotide binding]; other site 412694012393 L21 binding site [polypeptide binding]; other site 412694012394 L13 binding site [polypeptide binding]; other site 412694012395 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 412694012396 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 412694012397 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 412694012398 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 412694012399 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 412694012400 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 412694012401 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 412694012402 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 412694012403 active site 412694012404 dimer interface [polypeptide binding]; other site 412694012405 motif 1; other site 412694012406 motif 2; other site 412694012407 motif 3; other site 412694012408 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 412694012409 anticodon binding site; other site 412694012410 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 412694012411 primosomal protein DnaI; Reviewed; Region: PRK08939 412694012412 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 412694012413 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412694012414 Walker A motif; other site 412694012415 ATP binding site [chemical binding]; other site 412694012416 Walker B motif; other site 412694012417 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 412694012418 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 412694012419 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 412694012420 ATP cone domain; Region: ATP-cone; pfam03477 412694012421 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 412694012422 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 412694012423 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 412694012424 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 412694012425 dephospho-CoA kinase; Region: TIGR00152 412694012426 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 412694012427 CoA-binding site [chemical binding]; other site 412694012428 ATP-binding [chemical binding]; other site 412694012429 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 412694012430 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 412694012431 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 412694012432 DNA binding site [nucleotide binding] 412694012433 catalytic residue [active] 412694012434 H2TH interface [polypeptide binding]; other site 412694012435 putative catalytic residues [active] 412694012436 turnover-facilitating residue; other site 412694012437 intercalation triad [nucleotide binding]; other site 412694012438 8OG recognition residue [nucleotide binding]; other site 412694012439 putative reading head residues; other site 412694012440 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 412694012441 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 412694012442 DNA polymerase I; Provisional; Region: PRK05755 412694012443 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 412694012444 active site 412694012445 metal binding site 1 [ion binding]; metal-binding site 412694012446 putative 5' ssDNA interaction site; other site 412694012447 metal binding site 3; metal-binding site 412694012448 metal binding site 2 [ion binding]; metal-binding site 412694012449 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 412694012450 putative DNA binding site [nucleotide binding]; other site 412694012451 putative metal binding site [ion binding]; other site 412694012452 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 412694012453 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 412694012454 active site 412694012455 DNA binding site [nucleotide binding] 412694012456 catalytic site [active] 412694012457 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412694012458 dimerization interface [polypeptide binding]; other site 412694012459 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 412694012460 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 412694012461 putative active site [active] 412694012462 heme pocket [chemical binding]; other site 412694012463 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694012464 dimer interface [polypeptide binding]; other site 412694012465 phosphorylation site [posttranslational modification] 412694012466 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694012467 ATP binding site [chemical binding]; other site 412694012468 Mg2+ binding site [ion binding]; other site 412694012469 G-X-G motif; other site 412694012470 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412694012471 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694012472 active site 412694012473 phosphorylation site [posttranslational modification] 412694012474 intermolecular recognition site; other site 412694012475 dimerization interface [polypeptide binding]; other site 412694012476 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412694012477 DNA binding site [nucleotide binding] 412694012478 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 412694012479 active site 2 [active] 412694012480 active site 1 [active] 412694012481 malate dehydrogenase; Reviewed; Region: PRK06223 412694012482 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 412694012483 NAD(P) binding site [chemical binding]; other site 412694012484 dimer interface [polypeptide binding]; other site 412694012485 tetramer (dimer of dimers) interface [polypeptide binding]; other site 412694012486 substrate binding site [chemical binding]; other site 412694012487 isocitrate dehydrogenase; Reviewed; Region: PRK07006 412694012488 isocitrate dehydrogenase; Validated; Region: PRK07362 412694012489 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 412694012490 dimer interface [polypeptide binding]; other site 412694012491 Citrate synthase; Region: Citrate_synt; pfam00285 412694012492 active site 412694012493 citrylCoA binding site [chemical binding]; other site 412694012494 oxalacetate/citrate binding site [chemical binding]; other site 412694012495 coenzyme A binding site [chemical binding]; other site 412694012496 catalytic triad [active] 412694012497 Protein of unknown function (DUF441); Region: DUF441; pfam04284 412694012498 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 412694012499 Domain of unknown function DUF20; Region: UPF0118; pfam01594 412694012500 pyruvate kinase; Provisional; Region: PRK06354 412694012501 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 412694012502 domain interfaces; other site 412694012503 active site 412694012504 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 412694012505 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 412694012506 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 412694012507 active site 412694012508 ADP/pyrophosphate binding site [chemical binding]; other site 412694012509 dimerization interface [polypeptide binding]; other site 412694012510 allosteric effector site; other site 412694012511 fructose-1,6-bisphosphate binding site; other site 412694012512 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 412694012513 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 412694012514 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 412694012515 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 412694012516 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 412694012517 Transcriptional regulators [Transcription]; Region: FadR; COG2186 412694012518 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412694012519 DNA-binding site [nucleotide binding]; DNA binding site 412694012520 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 412694012521 Malic enzyme, N-terminal domain; Region: malic; pfam00390 412694012522 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 412694012523 putative NAD(P) binding site [chemical binding]; other site 412694012524 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 412694012525 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 412694012526 active site 412694012527 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 412694012528 generic binding surface II; other site 412694012529 generic binding surface I; other site 412694012530 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 412694012531 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 412694012532 DHH family; Region: DHH; pfam01368 412694012533 DHHA1 domain; Region: DHHA1; pfam02272 412694012534 Phosphotransferase enzyme family; Region: APH; pfam01636 412694012535 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 412694012536 active site 412694012537 ATP binding site [chemical binding]; other site 412694012538 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 412694012539 substrate binding site [chemical binding]; other site 412694012540 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 412694012541 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412694012542 DNA-binding site [nucleotide binding]; DNA binding site 412694012543 DRTGG domain; Region: DRTGG; pfam07085 412694012544 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 412694012545 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 412694012546 active site 2 [active] 412694012547 active site 1 [active] 412694012548 metal-dependent hydrolase; Provisional; Region: PRK00685 412694012549 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 412694012550 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 412694012551 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 412694012552 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 412694012553 active site 412694012554 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 412694012555 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 412694012556 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 412694012557 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 412694012558 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 412694012559 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 412694012560 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412694012561 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 412694012562 DNA binding residues [nucleotide binding] 412694012563 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 412694012564 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694012565 Coenzyme A binding pocket [chemical binding]; other site 412694012566 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 412694012567 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 412694012568 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412694012569 non-specific DNA binding site [nucleotide binding]; other site 412694012570 salt bridge; other site 412694012571 sequence-specific DNA binding site [nucleotide binding]; other site 412694012572 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 412694012573 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 412694012574 hexamer interface [polypeptide binding]; other site 412694012575 ligand binding site [chemical binding]; other site 412694012576 putative active site [active] 412694012577 NAD(P) binding site [chemical binding]; other site 412694012578 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 412694012579 classical (c) SDRs; Region: SDR_c; cd05233 412694012580 NAD(P) binding site [chemical binding]; other site 412694012581 active site 412694012582 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 412694012583 Ligand Binding Site [chemical binding]; other site 412694012584 argininosuccinate lyase; Provisional; Region: PRK00855 412694012585 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 412694012586 active sites [active] 412694012587 tetramer interface [polypeptide binding]; other site 412694012588 argininosuccinate synthase; Provisional; Region: PRK13820 412694012589 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 412694012590 ANP binding site [chemical binding]; other site 412694012591 Substrate Binding Site II [chemical binding]; other site 412694012592 Substrate Binding Site I [chemical binding]; other site 412694012593 Uncharacterized conserved protein [Function unknown]; Region: COG1284 412694012594 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 412694012595 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 412694012596 EcsC protein family; Region: EcsC; pfam12787 412694012597 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 412694012598 nudix motif; other site 412694012599 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 412694012600 propionate/acetate kinase; Provisional; Region: PRK12379 412694012601 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 412694012602 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694012603 S-adenosylmethionine binding site [chemical binding]; other site 412694012604 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 412694012605 dimer interface [polypeptide binding]; other site 412694012606 catalytic triad [active] 412694012607 peroxidatic and resolving cysteines [active] 412694012608 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 412694012609 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 412694012610 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 412694012611 ATP-NAD kinase; Region: NAD_kinase; pfam01513 412694012612 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 412694012613 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 412694012614 active site 412694012615 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 412694012616 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 412694012617 dimer interface [polypeptide binding]; other site 412694012618 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 412694012619 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 412694012620 active site 412694012621 acyl-activating enzyme (AAE) consensus motif; other site 412694012622 putative CoA binding site [chemical binding]; other site 412694012623 AMP binding site [chemical binding]; other site 412694012624 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 412694012625 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 412694012626 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 412694012627 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 412694012628 Ligand Binding Site [chemical binding]; other site 412694012629 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 412694012630 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 412694012631 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412694012632 catalytic residue [active] 412694012633 septation ring formation regulator EzrA; Provisional; Region: PRK04778 412694012634 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412694012635 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412694012636 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 412694012637 dimerization interface [polypeptide binding]; other site 412694012638 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 412694012639 EamA-like transporter family; Region: EamA; pfam00892 412694012640 EamA-like transporter family; Region: EamA; pfam00892 412694012641 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412694012642 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412694012643 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 412694012644 GAF domain; Region: GAF_2; pfam13185 412694012645 methionine gamma-lyase; Provisional; Region: PRK06767 412694012646 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 412694012647 homodimer interface [polypeptide binding]; other site 412694012648 substrate-cofactor binding pocket; other site 412694012649 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694012650 catalytic residue [active] 412694012651 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 412694012652 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 412694012653 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 412694012654 RNA binding surface [nucleotide binding]; other site 412694012655 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 412694012656 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 412694012657 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 412694012658 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 412694012659 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 412694012660 active site 412694012661 HIGH motif; other site 412694012662 dimer interface [polypeptide binding]; other site 412694012663 KMSKS motif; other site 412694012664 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 412694012665 RNA binding surface [nucleotide binding]; other site 412694012666 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 412694012667 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412694012668 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 412694012669 DNA binding residues [nucleotide binding] 412694012670 acetyl-CoA synthetase; Provisional; Region: PRK04319 412694012671 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 412694012672 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 412694012673 active site 412694012674 acyl-activating enzyme (AAE) consensus motif; other site 412694012675 putative CoA binding site [chemical binding]; other site 412694012676 AMP binding site [chemical binding]; other site 412694012677 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 412694012678 Coenzyme A binding pocket [chemical binding]; other site 412694012679 FOG: CBS domain [General function prediction only]; Region: COG0517 412694012680 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 412694012681 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 412694012682 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 412694012683 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 412694012684 active site 412694012685 Zn binding site [ion binding]; other site 412694012686 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 412694012687 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412694012688 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694012689 active site 412694012690 phosphorylation site [posttranslational modification] 412694012691 intermolecular recognition site; other site 412694012692 dimerization interface [polypeptide binding]; other site 412694012693 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412694012694 DNA binding site [nucleotide binding] 412694012695 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412694012696 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412694012697 dimerization interface [polypeptide binding]; other site 412694012698 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694012699 dimer interface [polypeptide binding]; other site 412694012700 phosphorylation site [posttranslational modification] 412694012701 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694012702 ATP binding site [chemical binding]; other site 412694012703 Mg2+ binding site [ion binding]; other site 412694012704 G-X-G motif; other site 412694012705 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 412694012706 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 412694012707 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 412694012708 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 412694012709 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 412694012710 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 412694012711 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 412694012712 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 412694012713 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 412694012714 catabolite control protein A; Region: ccpA; TIGR01481 412694012715 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 412694012716 DNA binding site [nucleotide binding] 412694012717 domain linker motif; other site 412694012718 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 412694012719 dimerization interface [polypeptide binding]; other site 412694012720 effector binding site; other site 412694012721 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 412694012722 putative dimer interface [polypeptide binding]; other site 412694012723 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 412694012724 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 412694012725 putative dimer interface [polypeptide binding]; other site 412694012726 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 412694012727 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 412694012728 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 412694012729 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 412694012730 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 412694012731 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 412694012732 Coenzyme A binding pocket [chemical binding]; other site 412694012733 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 412694012734 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 412694012735 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 412694012736 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 412694012737 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 412694012738 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 412694012739 active site 412694012740 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 412694012741 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 412694012742 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 412694012743 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 412694012744 putative tRNA-binding site [nucleotide binding]; other site 412694012745 hypothetical protein; Provisional; Region: PRK13668 412694012746 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 412694012747 catalytic residues [active] 412694012748 NTPase; Reviewed; Region: PRK03114 412694012749 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 412694012750 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 412694012751 oligomer interface [polypeptide binding]; other site 412694012752 active site 412694012753 metal binding site [ion binding]; metal-binding site 412694012754 Predicted small secreted protein [Function unknown]; Region: COG5584 412694012755 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 412694012756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694012757 S-adenosylmethionine binding site [chemical binding]; other site 412694012758 YtzH-like protein; Region: YtzH; pfam14165 412694012759 Phosphotransferase enzyme family; Region: APH; pfam01636 412694012760 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 412694012761 active site 412694012762 substrate binding site [chemical binding]; other site 412694012763 ATP binding site [chemical binding]; other site 412694012764 pullulanase, type I; Region: pulA_typeI; TIGR02104 412694012765 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 412694012766 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 412694012767 Ca binding site [ion binding]; other site 412694012768 active site 412694012769 catalytic site [active] 412694012770 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 412694012771 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 412694012772 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 412694012773 dipeptidase PepV; Reviewed; Region: PRK07318 412694012774 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 412694012775 active site 412694012776 metal binding site [ion binding]; metal-binding site 412694012777 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 412694012778 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 412694012779 RNA binding surface [nucleotide binding]; other site 412694012780 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 412694012781 active site 412694012782 uracil binding [chemical binding]; other site 412694012783 stage V sporulation protein B; Region: spore_V_B; TIGR02900 412694012784 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 412694012785 HI0933-like protein; Region: HI0933_like; pfam03486 412694012786 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 412694012787 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 412694012788 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694012789 putative substrate translocation pore; other site 412694012790 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412694012791 dimerization interface [polypeptide binding]; other site 412694012792 putative DNA binding site [nucleotide binding]; other site 412694012793 putative Zn2+ binding site [ion binding]; other site 412694012794 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 412694012795 putative hydrophobic ligand binding site [chemical binding]; other site 412694012796 Domain of unknown function (DUF3973); Region: DUF3973; pfam13119 412694012797 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 412694012798 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 412694012799 glucose-1-dehydrogenase; Provisional; Region: PRK08936 412694012800 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 412694012801 NAD binding site [chemical binding]; other site 412694012802 homodimer interface [polypeptide binding]; other site 412694012803 active site 412694012804 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 412694012805 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 412694012806 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 412694012807 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 412694012808 MoaE interaction surface [polypeptide binding]; other site 412694012809 MoeB interaction surface [polypeptide binding]; other site 412694012810 thiocarboxylated glycine; other site 412694012811 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 412694012812 MoaE homodimer interface [polypeptide binding]; other site 412694012813 MoaD interaction [polypeptide binding]; other site 412694012814 active site residues [active] 412694012815 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 412694012816 Walker A motif; other site 412694012817 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 412694012818 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 412694012819 dimer interface [polypeptide binding]; other site 412694012820 putative functional site; other site 412694012821 putative MPT binding site; other site 412694012822 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 412694012823 trimer interface [polypeptide binding]; other site 412694012824 dimer interface [polypeptide binding]; other site 412694012825 putative active site [active] 412694012826 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 412694012827 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 412694012828 ATP binding site [chemical binding]; other site 412694012829 substrate interface [chemical binding]; other site 412694012830 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 412694012831 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412694012832 FeS/SAM binding site; other site 412694012833 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 412694012834 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 412694012835 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 412694012836 active site residue [active] 412694012837 homoserine O-acetyltransferase; Provisional; Region: PRK06765 412694012838 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 412694012839 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 412694012840 Spore germination protein; Region: Spore_permease; pfam03845 412694012841 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 412694012842 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 412694012843 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 412694012844 putative nucleotide binding site [chemical binding]; other site 412694012845 putative metal binding site [ion binding]; other site 412694012846 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 412694012847 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 412694012848 HIGH motif; other site 412694012849 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 412694012850 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 412694012851 active site 412694012852 KMSKS motif; other site 412694012853 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 412694012854 tRNA binding surface [nucleotide binding]; other site 412694012855 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694012856 Major Facilitator Superfamily; Region: MFS_1; pfam07690 412694012857 putative substrate translocation pore; other site 412694012858 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 412694012859 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 412694012860 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 412694012861 TrkA-C domain; Region: TrkA_C; pfam02080 412694012862 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 412694012863 Int/Topo IB signature motif; other site 412694012864 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 412694012865 FtsX-like permease family; Region: FtsX; pfam02687 412694012866 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 412694012867 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 412694012868 Walker A/P-loop; other site 412694012869 ATP binding site [chemical binding]; other site 412694012870 Q-loop/lid; other site 412694012871 ABC transporter signature motif; other site 412694012872 Walker B; other site 412694012873 D-loop; other site 412694012874 H-loop/switch region; other site 412694012875 Protein of unknown function (DUF418); Region: DUF418; cl12135 412694012876 Protein of unknown function (DUF418); Region: DUF418; pfam04235 412694012877 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 412694012878 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 412694012879 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412694012880 FeS/SAM binding site; other site 412694012881 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694012882 S-adenosylmethionine binding site [chemical binding]; other site 412694012883 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 412694012884 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 412694012885 Walker A/P-loop; other site 412694012886 ATP binding site [chemical binding]; other site 412694012887 Q-loop/lid; other site 412694012888 ABC transporter signature motif; other site 412694012889 Walker B; other site 412694012890 D-loop; other site 412694012891 H-loop/switch region; other site 412694012892 aspartate racemase; Region: asp_race; TIGR00035 412694012893 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 412694012894 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 412694012895 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 412694012896 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 412694012897 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 412694012898 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 412694012899 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 412694012900 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 412694012901 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 412694012902 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 412694012903 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 412694012904 trimer interface [polypeptide binding]; other site 412694012905 putative metal binding site [ion binding]; other site 412694012906 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 412694012907 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 412694012908 active site 412694012909 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 412694012910 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 412694012911 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 412694012912 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 412694012913 GTP binding site; other site 412694012914 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 412694012915 MPT binding site; other site 412694012916 trimer interface [polypeptide binding]; other site 412694012917 S-adenosylmethionine synthetase; Validated; Region: PRK05250 412694012918 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 412694012919 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 412694012920 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 412694012921 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 412694012922 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 412694012923 active site 412694012924 substrate-binding site [chemical binding]; other site 412694012925 metal-binding site [ion binding] 412694012926 ATP binding site [chemical binding]; other site 412694012927 EamA-like transporter family; Region: EamA; pfam00892 412694012928 EamA-like transporter family; Region: EamA; pfam00892 412694012929 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 412694012930 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 412694012931 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412694012932 motif II; other site 412694012933 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 412694012934 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 412694012935 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 412694012936 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 412694012937 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412694012938 motif II; other site 412694012939 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694012940 ATP binding site [chemical binding]; other site 412694012941 Mg2+ binding site [ion binding]; other site 412694012942 G-X-G motif; other site 412694012943 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412694012944 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694012945 dimer interface [polypeptide binding]; other site 412694012946 phosphorylation site [posttranslational modification] 412694012947 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694012948 ATP binding site [chemical binding]; other site 412694012949 Mg2+ binding site [ion binding]; other site 412694012950 G-X-G motif; other site 412694012951 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 412694012952 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 412694012953 Secretory lipase; Region: LIP; pfam03583 412694012954 Sulfatase; Region: Sulfatase; pfam00884 412694012955 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 412694012956 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 412694012957 NMT1-like family; Region: NMT1_2; pfam13379 412694012958 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 412694012959 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 412694012960 Walker A/P-loop; other site 412694012961 ATP binding site [chemical binding]; other site 412694012962 Q-loop/lid; other site 412694012963 ABC transporter signature motif; other site 412694012964 Walker B; other site 412694012965 D-loop; other site 412694012966 H-loop/switch region; other site 412694012967 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 412694012968 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694012969 dimer interface [polypeptide binding]; other site 412694012970 conserved gate region; other site 412694012971 putative PBP binding loops; other site 412694012972 ABC-ATPase subunit interface; other site 412694012973 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 412694012974 active site 412694012975 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 412694012976 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412694012977 motif II; other site 412694012978 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 412694012979 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 412694012980 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 412694012981 nudix motif; other site 412694012982 S-ribosylhomocysteinase; Provisional; Region: PRK02260 412694012983 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 412694012984 active site clefts [active] 412694012985 zinc binding site [ion binding]; other site 412694012986 dimer interface [polypeptide binding]; other site 412694012987 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 412694012988 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 412694012989 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 412694012990 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 412694012991 S-layer homology domain; Region: SLH; pfam00395 412694012992 S-layer homology domain; Region: SLH; pfam00395 412694012993 S-layer homology domain; Region: SLH; pfam00395 412694012994 Excalibur calcium-binding domain; Region: Excalibur; smart00894 412694012995 Uncharacterized conserved protein [Function unknown]; Region: COG1434 412694012996 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 412694012997 putative active site [active] 412694012998 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 412694012999 Uncharacterized conserved protein [Function unknown]; Region: COG1284 412694013000 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 412694013001 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 412694013002 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 412694013003 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 412694013004 Predicted membrane protein [Function unknown]; Region: COG3766 412694013005 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 412694013006 hypothetical protein; Provisional; Region: PRK12473 412694013007 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 412694013008 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 412694013009 active site 412694013010 catalytic residues [active] 412694013011 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 412694013012 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 412694013013 G1 box; other site 412694013014 GTP/Mg2+ binding site [chemical binding]; other site 412694013015 Switch I region; other site 412694013016 G2 box; other site 412694013017 G3 box; other site 412694013018 Switch II region; other site 412694013019 G4 box; other site 412694013020 G5 box; other site 412694013021 Nucleoside recognition; Region: Gate; pfam07670 412694013022 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 412694013023 Nucleoside recognition; Region: Gate; pfam07670 412694013024 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 412694013025 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412694013026 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412694013027 dimerization interface [polypeptide binding]; other site 412694013028 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694013029 dimer interface [polypeptide binding]; other site 412694013030 phosphorylation site [posttranslational modification] 412694013031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694013032 ATP binding site [chemical binding]; other site 412694013033 Mg2+ binding site [ion binding]; other site 412694013034 G-X-G motif; other site 412694013035 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412694013036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694013037 active site 412694013038 phosphorylation site [posttranslational modification] 412694013039 intermolecular recognition site; other site 412694013040 dimerization interface [polypeptide binding]; other site 412694013041 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412694013042 DNA binding site [nucleotide binding] 412694013043 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 412694013044 active site 412694013045 catalytic site [active] 412694013046 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 412694013047 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 412694013048 active site 412694013049 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 412694013050 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 412694013051 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 412694013052 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 412694013053 Probable transposase; Region: OrfB_IS605; pfam01385 412694013054 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 412694013055 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 412694013056 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 412694013057 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 412694013058 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 412694013059 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694013060 S-adenosylmethionine binding site [chemical binding]; other site 412694013061 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 412694013062 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412694013063 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412694013064 YolD-like protein; Region: YolD; pfam08863 412694013065 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 412694013066 FtsX-like permease family; Region: FtsX; pfam02687 412694013067 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 412694013068 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 412694013069 Walker A/P-loop; other site 412694013070 ATP binding site [chemical binding]; other site 412694013071 Q-loop/lid; other site 412694013072 ABC transporter signature motif; other site 412694013073 Walker B; other site 412694013074 D-loop; other site 412694013075 H-loop/switch region; other site 412694013076 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 412694013077 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 412694013078 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 412694013079 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412694013080 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694013081 active site 412694013082 phosphorylation site [posttranslational modification] 412694013083 intermolecular recognition site; other site 412694013084 dimerization interface [polypeptide binding]; other site 412694013085 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412694013086 DNA binding site [nucleotide binding] 412694013087 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412694013088 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 412694013089 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694013090 ATP binding site [chemical binding]; other site 412694013091 Mg2+ binding site [ion binding]; other site 412694013092 G-X-G motif; other site 412694013093 FtsX-like permease family; Region: FtsX; pfam02687 412694013094 FtsX-like permease family; Region: FtsX; pfam02687 412694013095 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 412694013096 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 412694013097 Walker A/P-loop; other site 412694013098 ATP binding site [chemical binding]; other site 412694013099 Q-loop/lid; other site 412694013100 ABC transporter signature motif; other site 412694013101 Walker B; other site 412694013102 D-loop; other site 412694013103 H-loop/switch region; other site 412694013104 FtsX-like permease family; Region: FtsX; pfam02687 412694013105 GntP family permease; Region: GntP_permease; pfam02447 412694013106 fructuronate transporter; Provisional; Region: PRK10034; cl15264 412694013107 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 412694013108 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 412694013109 DNA-binding site [nucleotide binding]; DNA binding site 412694013110 UTRA domain; Region: UTRA; pfam07702 412694013111 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 412694013112 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 412694013113 substrate binding site [chemical binding]; other site 412694013114 ATP binding site [chemical binding]; other site 412694013115 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 412694013116 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 412694013117 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412694013118 catalytic residue [active] 412694013119 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 412694013120 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 412694013121 active site 412694013122 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 412694013123 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412694013124 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412694013125 dimerization interface [polypeptide binding]; other site 412694013126 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694013127 dimer interface [polypeptide binding]; other site 412694013128 phosphorylation site [posttranslational modification] 412694013129 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694013130 ATP binding site [chemical binding]; other site 412694013131 Mg2+ binding site [ion binding]; other site 412694013132 G-X-G motif; other site 412694013133 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412694013134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694013135 active site 412694013136 phosphorylation site [posttranslational modification] 412694013137 intermolecular recognition site; other site 412694013138 dimerization interface [polypeptide binding]; other site 412694013139 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412694013140 DNA binding site [nucleotide binding] 412694013141 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 412694013142 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 412694013143 active site 412694013144 octamer interface [polypeptide binding]; other site 412694013145 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 412694013146 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 412694013147 acyl-activating enzyme (AAE) consensus motif; other site 412694013148 putative AMP binding site [chemical binding]; other site 412694013149 putative active site [active] 412694013150 putative CoA binding site [chemical binding]; other site 412694013151 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 412694013152 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 412694013153 substrate binding site [chemical binding]; other site 412694013154 oxyanion hole (OAH) forming residues; other site 412694013155 trimer interface [polypeptide binding]; other site 412694013156 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 412694013157 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 412694013158 nucleophilic elbow; other site 412694013159 catalytic triad; other site 412694013160 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 412694013161 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 412694013162 dimer interface [polypeptide binding]; other site 412694013163 tetramer interface [polypeptide binding]; other site 412694013164 PYR/PP interface [polypeptide binding]; other site 412694013165 TPP binding site [chemical binding]; other site 412694013166 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 412694013167 TPP-binding site; other site 412694013168 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 412694013169 chorismate binding enzyme; Region: Chorismate_bind; cl10555 412694013170 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 412694013171 UbiA prenyltransferase family; Region: UbiA; pfam01040 412694013172 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 412694013173 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 412694013174 DNA-binding site [nucleotide binding]; DNA binding site 412694013175 RNA-binding motif; other site 412694013176 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 412694013177 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 412694013178 active site flap/lid [active] 412694013179 nucleophilic elbow; other site 412694013180 catalytic triad [active] 412694013181 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 412694013182 homodimer interface [polypeptide binding]; other site 412694013183 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 412694013184 active site pocket [active] 412694013185 glycogen synthase; Provisional; Region: glgA; PRK00654 412694013186 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 412694013187 ADP-binding pocket [chemical binding]; other site 412694013188 homodimer interface [polypeptide binding]; other site 412694013189 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 412694013190 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 412694013191 ligand binding site; other site 412694013192 oligomer interface; other site 412694013193 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 412694013194 dimer interface [polypeptide binding]; other site 412694013195 N-terminal domain interface [polypeptide binding]; other site 412694013196 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 412694013197 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 412694013198 ligand binding site; other site 412694013199 oligomer interface; other site 412694013200 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 412694013201 dimer interface [polypeptide binding]; other site 412694013202 N-terminal domain interface [polypeptide binding]; other site 412694013203 sulfate 1 binding site; other site 412694013204 glycogen branching enzyme; Provisional; Region: PRK12313 412694013205 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 412694013206 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 412694013207 active site 412694013208 catalytic site [active] 412694013209 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 412694013210 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 412694013211 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 412694013212 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 412694013213 putative active site [active] 412694013214 catalytic triad [active] 412694013215 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 412694013216 PA/protease domain interface [polypeptide binding]; other site 412694013217 putative integrin binding motif; other site 412694013218 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 412694013219 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 412694013220 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 412694013221 dockerin binding interface; other site 412694013222 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 412694013223 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 412694013224 tetramer (dimer of dimers) interface [polypeptide binding]; other site 412694013225 NAD binding site [chemical binding]; other site 412694013226 dimer interface [polypeptide binding]; other site 412694013227 substrate binding site [chemical binding]; other site 412694013228 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 412694013229 MgtC family; Region: MgtC; pfam02308 412694013230 Ion channel; Region: Ion_trans_2; pfam07885 412694013231 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 412694013232 TrkA-N domain; Region: TrkA_N; pfam02254 412694013233 YugN-like family; Region: YugN; pfam08868 412694013234 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 412694013235 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 412694013236 active site 412694013237 dimer interface [polypeptide binding]; other site 412694013238 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 412694013239 dimer interface [polypeptide binding]; other site 412694013240 active site 412694013241 general stress protein 13; Validated; Region: PRK08059 412694013242 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 412694013243 RNA binding site [nucleotide binding]; other site 412694013244 hypothetical protein; Validated; Region: PRK07682 412694013245 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412694013246 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694013247 homodimer interface [polypeptide binding]; other site 412694013248 catalytic residue [active] 412694013249 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 412694013250 AsnC family; Region: AsnC_trans_reg; pfam01037 412694013251 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 412694013252 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 412694013253 dimerization interface [polypeptide binding]; other site 412694013254 ligand binding site [chemical binding]; other site 412694013255 NADP binding site [chemical binding]; other site 412694013256 catalytic site [active] 412694013257 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 412694013258 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 412694013259 nucleophilic elbow; other site 412694013260 catalytic triad; other site 412694013261 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 412694013262 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 412694013263 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412694013264 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694013265 homodimer interface [polypeptide binding]; other site 412694013266 catalytic residue [active] 412694013267 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 412694013268 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 412694013269 E-class dimer interface [polypeptide binding]; other site 412694013270 P-class dimer interface [polypeptide binding]; other site 412694013271 active site 412694013272 Cu2+ binding site [ion binding]; other site 412694013273 Zn2+ binding site [ion binding]; other site 412694013274 Kinase associated protein B; Region: KapB; pfam08810 412694013275 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 412694013276 active site 412694013277 catalytic site [active] 412694013278 substrate binding site [chemical binding]; other site 412694013279 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 412694013280 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 412694013281 transmembrane helices; other site 412694013282 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 412694013283 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 412694013284 active site 412694013285 glycyl-tRNA synthetase; Provisional; Region: PRK04173 412694013286 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 412694013287 motif 1; other site 412694013288 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 412694013289 active site 412694013290 motif 2; other site 412694013291 motif 3; other site 412694013292 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 412694013293 anticodon binding site; other site 412694013294 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 412694013295 CoenzymeA binding site [chemical binding]; other site 412694013296 subunit interaction site [polypeptide binding]; other site 412694013297 PHB binding site; other site 412694013298 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 412694013299 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 412694013300 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 412694013301 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 412694013302 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 412694013303 active site 412694013304 tetramer interface; other site 412694013305 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 412694013306 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 412694013307 active site 412694013308 substrate binding site [chemical binding]; other site 412694013309 metal binding site [ion binding]; metal-binding site 412694013310 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 412694013311 Uncharacterized conserved protein [Function unknown]; Region: COG1624 412694013312 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 412694013313 multifunctional aminopeptidase A; Provisional; Region: PRK00913 412694013314 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 412694013315 interface (dimer of trimers) [polypeptide binding]; other site 412694013316 Substrate-binding/catalytic site; other site 412694013317 Zn-binding sites [ion binding]; other site 412694013318 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 412694013319 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 412694013320 nudix motif; other site 412694013321 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 412694013322 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 412694013323 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 412694013324 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 412694013325 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 412694013326 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 412694013327 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 412694013328 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 412694013329 Domain of unknown function DUF11; Region: DUF11; pfam01345 412694013330 Domain of unknown function DUF11; Region: DUF11; pfam01345 412694013331 Domain of unknown function DUF11; Region: DUF11; pfam01345 412694013332 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 412694013333 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 412694013334 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 412694013335 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 412694013336 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 412694013337 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 412694013338 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 412694013339 conserved repeat domain; Region: B_ant_repeat; TIGR01451 412694013340 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 412694013341 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 412694013342 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 412694013343 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 412694013344 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 412694013345 H+ Antiporter protein; Region: 2A0121; TIGR00900 412694013346 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694013347 putative substrate translocation pore; other site 412694013348 Helix-turn-helix domain; Region: HTH_36; pfam13730 412694013349 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 412694013350 Protein of unknown function (DUF523); Region: DUF523; pfam04463 412694013351 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 412694013352 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 412694013353 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 412694013354 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 412694013355 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 412694013356 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 412694013357 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 412694013358 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 412694013359 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412694013360 Walker A/P-loop; other site 412694013361 ATP binding site [chemical binding]; other site 412694013362 Q-loop/lid; other site 412694013363 ABC transporter signature motif; other site 412694013364 Walker B; other site 412694013365 D-loop; other site 412694013366 H-loop/switch region; other site 412694013367 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 412694013368 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 412694013369 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 412694013370 PhnA protein; Region: PhnA; pfam03831 412694013371 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 412694013372 CAAX protease self-immunity; Region: Abi; pfam02517 412694013373 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 412694013374 active site 412694013375 NTP binding site [chemical binding]; other site 412694013376 metal binding triad [ion binding]; metal-binding site 412694013377 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 412694013378 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 412694013379 NifU-like domain; Region: NifU; pfam01106 412694013380 spore coat protein YutH; Region: spore_yutH; TIGR02905 412694013381 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 412694013382 tetramer interfaces [polypeptide binding]; other site 412694013383 binuclear metal-binding site [ion binding]; other site 412694013384 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 412694013385 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 412694013386 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 412694013387 FtsX-like permease family; Region: FtsX; pfam02687 412694013388 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 412694013389 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 412694013390 FtsX-like permease family; Region: FtsX; pfam02687 412694013391 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 412694013392 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 412694013393 Walker A/P-loop; other site 412694013394 ATP binding site [chemical binding]; other site 412694013395 Q-loop/lid; other site 412694013396 ABC transporter signature motif; other site 412694013397 Walker B; other site 412694013398 D-loop; other site 412694013399 H-loop/switch region; other site 412694013400 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 412694013401 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 412694013402 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 412694013403 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412694013404 active site 412694013405 motif I; other site 412694013406 motif II; other site 412694013407 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412694013408 Predicted transcriptional regulator [Transcription]; Region: COG2345 412694013409 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412694013410 putative Zn2+ binding site [ion binding]; other site 412694013411 putative DNA binding site [nucleotide binding]; other site 412694013412 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 412694013413 Uncharacterized conserved protein [Function unknown]; Region: COG2445 412694013414 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 412694013415 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 412694013416 putative active site [active] 412694013417 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 412694013418 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 412694013419 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 412694013420 RNA binding surface [nucleotide binding]; other site 412694013421 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 412694013422 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 412694013423 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 412694013424 DNA binding residues [nucleotide binding] 412694013425 dimer interface [polypeptide binding]; other site 412694013426 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 412694013427 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 412694013428 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 412694013429 catalytic core [active] 412694013430 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 412694013431 putative deacylase active site [active] 412694013432 lipoyl synthase; Provisional; Region: PRK05481 412694013433 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412694013434 FeS/SAM binding site; other site 412694013435 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 412694013436 Peptidase family M23; Region: Peptidase_M23; pfam01551 412694013437 sporulation protein YunB; Region: spo_yunB; TIGR02832 412694013438 Uncharacterized conserved protein [Function unknown]; Region: COG3377 412694013439 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 412694013440 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 412694013441 active site 412694013442 metal binding site [ion binding]; metal-binding site 412694013443 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 412694013444 Predicted transcriptional regulators [Transcription]; Region: COG1695 412694013445 Transcriptional regulator PadR-like family; Region: PadR; cl17335 412694013446 VanZ like family; Region: VanZ; pfam04892 412694013447 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 412694013448 FeS assembly protein SufB; Region: sufB; TIGR01980 412694013449 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 412694013450 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 412694013451 trimerization site [polypeptide binding]; other site 412694013452 active site 412694013453 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 412694013454 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 412694013455 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412694013456 catalytic residue [active] 412694013457 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 412694013458 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 412694013459 FeS assembly protein SufD; Region: sufD; TIGR01981 412694013460 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 412694013461 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 412694013462 Walker A/P-loop; other site 412694013463 ATP binding site [chemical binding]; other site 412694013464 Q-loop/lid; other site 412694013465 ABC transporter signature motif; other site 412694013466 Walker B; other site 412694013467 D-loop; other site 412694013468 H-loop/switch region; other site 412694013469 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 412694013470 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 412694013471 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 412694013472 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 412694013473 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412694013474 ABC-ATPase subunit interface; other site 412694013475 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 412694013476 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 412694013477 Walker A/P-loop; other site 412694013478 ATP binding site [chemical binding]; other site 412694013479 Q-loop/lid; other site 412694013480 ABC transporter signature motif; other site 412694013481 Walker B; other site 412694013482 D-loop; other site 412694013483 H-loop/switch region; other site 412694013484 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 412694013485 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 412694013486 catalytic residues [active] 412694013487 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 412694013488 putative active site [active] 412694013489 putative metal binding site [ion binding]; other site 412694013490 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 412694013491 lipoyl attachment site [posttranslational modification]; other site 412694013492 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 412694013493 ArsC family; Region: ArsC; pfam03960 412694013494 putative ArsC-like catalytic residues; other site 412694013495 putative TRX-like catalytic residues [active] 412694013496 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 412694013497 active site 412694013498 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 412694013499 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 412694013500 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 412694013501 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 412694013502 tetramer (dimer of dimers) interface [polypeptide binding]; other site 412694013503 NAD binding site [chemical binding]; other site 412694013504 dimer interface [polypeptide binding]; other site 412694013505 substrate binding site [chemical binding]; other site 412694013506 Coat F domain; Region: Coat_F; pfam07875 412694013507 CAAX protease self-immunity; Region: Abi; pfam02517 412694013508 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412694013509 salt bridge; other site 412694013510 non-specific DNA binding site [nucleotide binding]; other site 412694013511 sequence-specific DNA binding site [nucleotide binding]; other site 412694013512 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412694013513 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412694013514 WHG domain; Region: WHG; pfam13305 412694013515 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 412694013516 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 412694013517 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 412694013518 Walker A/P-loop; other site 412694013519 ATP binding site [chemical binding]; other site 412694013520 Q-loop/lid; other site 412694013521 ABC transporter signature motif; other site 412694013522 Walker B; other site 412694013523 D-loop; other site 412694013524 H-loop/switch region; other site 412694013525 Integral membrane protein DUF95; Region: DUF95; cl00572 412694013526 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 412694013527 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 412694013528 active site 412694013529 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 412694013530 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 412694013531 dimer interface [polypeptide binding]; other site 412694013532 active site 412694013533 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 412694013534 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 412694013535 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 412694013536 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 412694013537 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 412694013538 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 412694013539 substrate binding site [chemical binding]; other site 412694013540 oxyanion hole (OAH) forming residues; other site 412694013541 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 412694013542 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 412694013543 Proline dehydrogenase; Region: Pro_dh; cl03282 412694013544 Domain of unknown function DUF77; Region: DUF77; pfam01910 412694013545 Cache domain; Region: Cache_1; pfam02743 412694013546 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412694013547 dimerization interface [polypeptide binding]; other site 412694013548 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 412694013549 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 412694013550 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 412694013551 dimer interface [polypeptide binding]; other site 412694013552 putative CheW interface [polypeptide binding]; other site 412694013553 Predicted transcriptional regulators [Transcription]; Region: COG1378 412694013554 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 412694013555 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 412694013556 C-terminal domain interface [polypeptide binding]; other site 412694013557 sugar binding site [chemical binding]; other site 412694013558 TQXA domain; Region: TQXA_dom; TIGR03934 412694013559 Cna protein B-type domain; Region: Cna_B; pfam05738 412694013560 Cna protein B-type domain; Region: Cna_B; pfam05738 412694013561 Cna protein B-type domain; Region: Cna_B; pfam05738 412694013562 Cna protein B-type domain; Region: Cna_B; pfam05738 412694013563 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 412694013564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694013565 putative substrate translocation pore; other site 412694013566 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 412694013567 Spore germination protein; Region: Spore_permease; cl17796 412694013568 MAEBL; Provisional; Region: PTZ00121 412694013569 OxaA-like protein precursor; Validated; Region: PRK01622 412694013570 Uncharacterized conserved protein [Function unknown]; Region: COG1284 412694013571 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 412694013572 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 412694013573 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 412694013574 active site 412694013575 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 412694013576 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412694013577 non-specific DNA binding site [nucleotide binding]; other site 412694013578 salt bridge; other site 412694013579 sequence-specific DNA binding site [nucleotide binding]; other site 412694013580 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 412694013581 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 412694013582 Protein of unknown function (DUF3978); Region: DUF3978; pfam13123 412694013583 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 412694013584 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 412694013585 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412694013586 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694013587 active site 412694013588 phosphorylation site [posttranslational modification] 412694013589 intermolecular recognition site; other site 412694013590 dimerization interface [polypeptide binding]; other site 412694013591 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412694013592 DNA binding site [nucleotide binding] 412694013593 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 412694013594 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694013595 dimer interface [polypeptide binding]; other site 412694013596 phosphorylation site [posttranslational modification] 412694013597 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694013598 ATP binding site [chemical binding]; other site 412694013599 Mg2+ binding site [ion binding]; other site 412694013600 G-X-G motif; other site 412694013601 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 412694013602 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 412694013603 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 412694013604 active site 412694013605 HIGH motif; other site 412694013606 KMSKS motif; other site 412694013607 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 412694013608 tRNA binding surface [nucleotide binding]; other site 412694013609 anticodon binding site; other site 412694013610 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 412694013611 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694013612 S-adenosylmethionine binding site [chemical binding]; other site 412694013613 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412694013614 dimerization interface [polypeptide binding]; other site 412694013615 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 412694013616 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 412694013617 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 412694013618 dimer interface [polypeptide binding]; other site 412694013619 putative CheW interface [polypeptide binding]; other site 412694013620 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412694013621 dimerization interface [polypeptide binding]; other site 412694013622 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 412694013623 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 412694013624 dimer interface [polypeptide binding]; other site 412694013625 putative CheW interface [polypeptide binding]; other site 412694013626 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 412694013627 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 412694013628 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 412694013629 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 412694013630 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 412694013631 active site 412694013632 Zn binding site [ion binding]; other site 412694013633 Pirin-related protein [General function prediction only]; Region: COG1741 412694013634 Pirin; Region: Pirin; pfam02678 412694013635 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 412694013636 MarR family; Region: MarR_2; pfam12802 412694013637 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 412694013638 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 412694013639 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 412694013640 TrkA-C domain; Region: TrkA_C; pfam02080 412694013641 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 412694013642 amino acid carrier protein; Region: agcS; TIGR00835 412694013643 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 412694013644 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 412694013645 dimerization interface [polypeptide binding]; other site 412694013646 DPS ferroxidase diiron center [ion binding]; other site 412694013647 ion pore; other site 412694013648 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 412694013649 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 412694013650 metal binding site [ion binding]; metal-binding site 412694013651 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 412694013652 Ferritin-like domain; Region: Ferritin; pfam00210 412694013653 ferroxidase diiron center [ion binding]; other site 412694013654 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 412694013655 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 412694013656 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 412694013657 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 412694013658 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 412694013659 Nucleoside recognition; Region: Gate; pfam07670 412694013660 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 412694013661 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 412694013662 amino acid carrier protein; Region: agcS; TIGR00835 412694013663 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 412694013664 amino acid carrier protein; Region: agcS; TIGR00835 412694013665 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 412694013666 NADH(P)-binding; Region: NAD_binding_10; pfam13460 412694013667 NAD binding site [chemical binding]; other site 412694013668 substrate binding site [chemical binding]; other site 412694013669 putative active site [active] 412694013670 Peptidase M60-like family; Region: M60-like; pfam13402 412694013671 TQXA domain; Region: TQXA_dom; TIGR03934 412694013672 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 412694013673 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 412694013674 active site 412694013675 catalytic tetrad [active] 412694013676 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 412694013677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694013678 putative substrate translocation pore; other site 412694013679 Predicted transcriptional regulators [Transcription]; Region: COG1733 412694013680 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412694013681 dimerization interface [polypeptide binding]; other site 412694013682 putative DNA binding site [nucleotide binding]; other site 412694013683 putative Zn2+ binding site [ion binding]; other site 412694013684 Uncharacterized conserved protein [Function unknown]; Region: COG2427 412694013685 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 412694013686 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 412694013687 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 412694013688 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 412694013689 active site 412694013690 HIGH motif; other site 412694013691 dimer interface [polypeptide binding]; other site 412694013692 KMSKS motif; other site 412694013693 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 412694013694 RNA binding surface [nucleotide binding]; other site 412694013695 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK12436 412694013696 FAD binding domain; Region: FAD_binding_4; pfam01565 412694013697 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 412694013698 SET domain; Region: SET; pfam00856 412694013699 Domain of unknown function (DUF4077); Region: DUF4077; pfam13295 412694013700 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 412694013701 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 412694013702 dimer interface [polypeptide binding]; other site 412694013703 putative CheW interface [polypeptide binding]; other site 412694013704 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 412694013705 putative catalytic site [active] 412694013706 putative metal binding site [ion binding]; other site 412694013707 putative phosphate binding site [ion binding]; other site 412694013708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694013709 H+ Antiporter protein; Region: 2A0121; TIGR00900 412694013710 putative substrate translocation pore; other site 412694013711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694013712 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 412694013713 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 412694013714 Domain of unknown function DUF87; Region: DUF87; pfam01935 412694013715 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 412694013716 ABC transporter; Region: ABC_tran_2; pfam12848 412694013717 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 412694013718 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 412694013719 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412694013720 Coenzyme A binding pocket [chemical binding]; other site 412694013721 Nuclease-related domain; Region: NERD; pfam08378 412694013722 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 412694013723 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 412694013724 Walker A/P-loop; other site 412694013725 ATP binding site [chemical binding]; other site 412694013726 Q-loop/lid; other site 412694013727 ABC transporter signature motif; other site 412694013728 Walker B; other site 412694013729 D-loop; other site 412694013730 H-loop/switch region; other site 412694013731 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 412694013732 ABC-ATPase subunit interface; other site 412694013733 dimer interface [polypeptide binding]; other site 412694013734 putative PBP binding regions; other site 412694013735 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 412694013736 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 412694013737 ABC-ATPase subunit interface; other site 412694013738 dimer interface [polypeptide binding]; other site 412694013739 putative PBP binding regions; other site 412694013740 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 412694013741 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 412694013742 putative ligand binding residues [chemical binding]; other site 412694013743 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412694013744 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694013745 active site 412694013746 phosphorylation site [posttranslational modification] 412694013747 intermolecular recognition site; other site 412694013748 dimerization interface [polypeptide binding]; other site 412694013749 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412694013750 DNA binding site [nucleotide binding] 412694013751 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 412694013752 SmpB-tmRNA interface; other site 412694013753 ribonuclease R; Region: RNase_R; TIGR02063 412694013754 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 412694013755 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 412694013756 RNB domain; Region: RNB; pfam00773 412694013757 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 412694013758 RNA binding site [nucleotide binding]; other site 412694013759 Esterase/lipase [General function prediction only]; Region: COG1647 412694013760 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 412694013761 holin-like protein; Validated; Region: PRK01658 412694013762 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 412694013763 active site 412694013764 enolase; Provisional; Region: eno; PRK00077 412694013765 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 412694013766 dimer interface [polypeptide binding]; other site 412694013767 metal binding site [ion binding]; metal-binding site 412694013768 substrate binding pocket [chemical binding]; other site 412694013769 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 412694013770 phosphoglyceromutase; Provisional; Region: PRK05434 412694013771 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 412694013772 triosephosphate isomerase; Provisional; Region: PRK14565 412694013773 substrate binding site [chemical binding]; other site 412694013774 dimer interface [polypeptide binding]; other site 412694013775 catalytic triad [active] 412694013776 Phosphoglycerate kinase; Region: PGK; pfam00162 412694013777 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 412694013778 substrate binding site [chemical binding]; other site 412694013779 hinge regions; other site 412694013780 ADP binding site [chemical binding]; other site 412694013781 catalytic site [active] 412694013782 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 412694013783 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 412694013784 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 412694013785 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 412694013786 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 412694013787 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 412694013788 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 412694013789 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 412694013790 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 412694013791 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 412694013792 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 412694013793 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 412694013794 stage V sporulation protein AD; Provisional; Region: PRK12404 412694013795 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 412694013796 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 412694013797 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 412694013798 Predicted membrane protein [Function unknown]; Region: COG2323 412694013799 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 412694013800 Clp protease; Region: CLP_protease; pfam00574 412694013801 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 412694013802 oligomer interface [polypeptide binding]; other site 412694013803 active site residues [active] 412694013804 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 412694013805 dimerization domain swap beta strand [polypeptide binding]; other site 412694013806 regulatory protein interface [polypeptide binding]; other site 412694013807 active site 412694013808 regulatory phosphorylation site [posttranslational modification]; other site 412694013809 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 412694013810 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 412694013811 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 412694013812 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 412694013813 phosphate binding site [ion binding]; other site 412694013814 putative substrate binding pocket [chemical binding]; other site 412694013815 dimer interface [polypeptide binding]; other site 412694013816 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 412694013817 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 412694013818 putative active site [active] 412694013819 nucleotide binding site [chemical binding]; other site 412694013820 nudix motif; other site 412694013821 putative metal binding site [ion binding]; other site 412694013822 Domain of unknown function (DUF368); Region: DUF368; pfam04018 412694013823 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 412694013824 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 412694013825 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 412694013826 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412694013827 binding surface 412694013828 TPR motif; other site 412694013829 Tetratricopeptide repeat; Region: TPR_12; pfam13424 412694013830 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412694013831 binding surface 412694013832 Tetratricopeptide repeat; Region: TPR_16; pfam13432 412694013833 TPR motif; other site 412694013834 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 412694013835 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 412694013836 trimer interface [polypeptide binding]; other site 412694013837 active site 412694013838 substrate binding site [chemical binding]; other site 412694013839 CoA binding site [chemical binding]; other site 412694013840 pyrophosphatase PpaX; Provisional; Region: PRK13288 412694013841 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412694013842 active site 412694013843 motif I; other site 412694013844 motif II; other site 412694013845 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 412694013846 HPr kinase/phosphorylase; Provisional; Region: PRK05428 412694013847 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 412694013848 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 412694013849 Hpr binding site; other site 412694013850 active site 412694013851 homohexamer subunit interaction site [polypeptide binding]; other site 412694013852 Predicted membrane protein [Function unknown]; Region: COG1950 412694013853 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 412694013854 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 412694013855 HlyD family secretion protein; Region: HlyD_3; pfam13437 412694013856 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 412694013857 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 412694013858 putative active site [active] 412694013859 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 412694013860 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412694013861 Walker A/P-loop; other site 412694013862 ATP binding site [chemical binding]; other site 412694013863 Q-loop/lid; other site 412694013864 ABC transporter signature motif; other site 412694013865 Walker B; other site 412694013866 D-loop; other site 412694013867 H-loop/switch region; other site 412694013868 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 412694013869 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 412694013870 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 412694013871 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 412694013872 excinuclease ABC subunit B; Provisional; Region: PRK05298 412694013873 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 412694013874 ATP binding site [chemical binding]; other site 412694013875 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412694013876 nucleotide binding region [chemical binding]; other site 412694013877 ATP-binding site [chemical binding]; other site 412694013878 Ultra-violet resistance protein B; Region: UvrB; pfam12344 412694013879 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 412694013880 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 412694013881 DNA binding residues [nucleotide binding] 412694013882 dimer interface [polypeptide binding]; other site 412694013883 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 412694013884 Predicted membrane protein [Function unknown]; Region: COG2855 412694013885 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412694013886 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412694013887 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 412694013888 putative dimerization interface [polypeptide binding]; other site 412694013889 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 412694013890 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 412694013891 DNA binding residues [nucleotide binding] 412694013892 putative dimer interface [polypeptide binding]; other site 412694013893 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 412694013894 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 412694013895 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 412694013896 hypothetical protein; Provisional; Region: PRK12855 412694013897 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 412694013898 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 412694013899 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 412694013900 Walker A/P-loop; other site 412694013901 ATP binding site [chemical binding]; other site 412694013902 Q-loop/lid; other site 412694013903 ABC transporter signature motif; other site 412694013904 Walker B; other site 412694013905 D-loop; other site 412694013906 H-loop/switch region; other site 412694013907 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 412694013908 protein binding site [polypeptide binding]; other site 412694013909 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 412694013910 C-terminal peptidase (prc); Region: prc; TIGR00225 412694013911 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 412694013912 protein binding site [polypeptide binding]; other site 412694013913 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 412694013914 Catalytic dyad [active] 412694013915 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 412694013916 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 412694013917 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 412694013918 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 412694013919 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412694013920 Walker A/P-loop; other site 412694013921 ATP binding site [chemical binding]; other site 412694013922 Q-loop/lid; other site 412694013923 ABC transporter signature motif; other site 412694013924 Walker B; other site 412694013925 D-loop; other site 412694013926 H-loop/switch region; other site 412694013927 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 412694013928 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 412694013929 peptide chain release factor 2; Provisional; Region: PRK06746 412694013930 This domain is found in peptide chain release factors; Region: PCRF; smart00937 412694013931 RF-1 domain; Region: RF-1; pfam00472 412694013932 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 412694013933 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 412694013934 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 412694013935 nucleotide binding region [chemical binding]; other site 412694013936 ATP-binding site [chemical binding]; other site 412694013937 SEC-C motif; Region: SEC-C; pfam02810 412694013938 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 412694013939 30S subunit binding site; other site 412694013940 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 412694013941 DNA-binding site [nucleotide binding]; DNA binding site 412694013942 RNA-binding motif; other site 412694013943 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 412694013944 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 412694013945 active site 412694013946 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 412694013947 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 412694013948 ATP binding site [chemical binding]; other site 412694013949 putative Mg++ binding site [ion binding]; other site 412694013950 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412694013951 nucleotide binding region [chemical binding]; other site 412694013952 ATP-binding site [chemical binding]; other site 412694013953 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 412694013954 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 412694013955 NlpC/P60 family; Region: NLPC_P60; pfam00877 412694013956 EDD domain protein, DegV family; Region: DegV; TIGR00762 412694013957 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 412694013958 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 412694013959 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 412694013960 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 412694013961 Transcriptional regulator [Transcription]; Region: LytR; COG1316 412694013962 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 412694013963 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 412694013964 active site 412694013965 homodimer interface [polypeptide binding]; other site 412694013966 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 412694013967 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 412694013968 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 412694013969 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 412694013970 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 412694013971 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 412694013972 Mg++ binding site [ion binding]; other site 412694013973 putative catalytic motif [active] 412694013974 substrate binding site [chemical binding]; other site 412694013975 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 412694013976 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 412694013977 NodB motif; other site 412694013978 active site 412694013979 catalytic site [active] 412694013980 Zn binding site [ion binding]; other site 412694013981 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412694013982 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 412694013983 Walker A motif; other site 412694013984 ATP binding site [chemical binding]; other site 412694013985 Walker B motif; other site 412694013986 arginine finger; other site 412694013987 Transcriptional antiterminator [Transcription]; Region: COG3933 412694013988 PRD domain; Region: PRD; pfam00874 412694013989 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 412694013990 active pocket/dimerization site; other site 412694013991 active site 412694013992 phosphorylation site [posttranslational modification] 412694013993 PRD domain; Region: PRD; pfam00874 412694013994 A domain in the BMP inhibitor chordin and in microbial proteins; Region: CHRD; smart00754 412694013995 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 412694013996 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 412694013997 Chromate transporter; Region: Chromate_transp; pfam02417 412694013998 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 412694013999 putative active site [active] 412694014000 YdjC motif; other site 412694014001 Mg binding site [ion binding]; other site 412694014002 putative homodimer interface [polypeptide binding]; other site 412694014003 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 412694014004 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 412694014005 NAD binding site [chemical binding]; other site 412694014006 sugar binding site [chemical binding]; other site 412694014007 divalent metal binding site [ion binding]; other site 412694014008 tetramer (dimer of dimers) interface [polypeptide binding]; other site 412694014009 dimer interface [polypeptide binding]; other site 412694014010 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 412694014011 active site 412694014012 methionine cluster; other site 412694014013 phosphorylation site [posttranslational modification] 412694014014 metal binding site [ion binding]; metal-binding site 412694014015 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 412694014016 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 412694014017 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 412694014018 active site 412694014019 P-loop; other site 412694014020 phosphorylation site [posttranslational modification] 412694014021 spermidine synthase; Provisional; Region: PRK03612 412694014022 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694014023 S-adenosylmethionine binding site [chemical binding]; other site 412694014024 S-adenosylmethionine decarboxylase proenzyme; Validated; Region: PRK01706 412694014025 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 412694014026 LytTr DNA-binding domain; Region: LytTR; smart00850 412694014027 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 412694014028 methionine cluster; other site 412694014029 active site 412694014030 phosphorylation site [posttranslational modification] 412694014031 metal binding site [ion binding]; metal-binding site 412694014032 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 412694014033 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 412694014034 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 412694014035 active site 412694014036 P-loop; other site 412694014037 phosphorylation site [posttranslational modification] 412694014038 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 412694014039 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 412694014040 Acyltransferase family; Region: Acyl_transf_3; pfam01757 412694014041 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 412694014042 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 412694014043 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 412694014044 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 412694014045 active site 412694014046 catalytic site [active] 412694014047 Cna protein B-type domain; Region: Cna_B; pfam05738 412694014048 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 412694014049 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 412694014050 Domain of unknown function DUF11; Region: DUF11; pfam01345 412694014051 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 412694014052 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 412694014053 Domain of unknown function DUF11; Region: DUF11; cl17728 412694014054 Cna protein B-type domain; Region: Cna_B; pfam05738 412694014055 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 412694014056 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 412694014057 Predicted membrane protein [Function unknown]; Region: COG1511 412694014058 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 412694014059 Transcriptional regulator [Transcription]; Region: LysR; COG0583 412694014060 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 412694014061 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 412694014062 putative dimerization interface [polypeptide binding]; other site 412694014063 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 412694014064 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 412694014065 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 412694014066 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 412694014067 transmembrane helices; other site 412694014068 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 412694014069 ThiC-associated domain; Region: ThiC-associated; pfam13667 412694014070 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 412694014071 L-lactate permease; Region: Lactate_perm; cl00701 412694014072 glycolate transporter; Provisional; Region: PRK09695 412694014073 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 412694014074 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 412694014075 Probable transposase; Region: OrfB_IS605; pfam01385 412694014076 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 412694014077 Uncharacterized conserved protein [Function unknown]; Region: COG3339 412694014078 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 412694014079 Sulfatase; Region: Sulfatase; pfam00884 412694014080 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 412694014081 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 412694014082 homodimer interface [polypeptide binding]; other site 412694014083 substrate-cofactor binding pocket; other site 412694014084 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694014085 catalytic residue [active] 412694014086 Bacterial SH3 domain; Region: SH3_3; pfam08239 412694014087 Bacterial SH3 domain; Region: SH3_3; pfam08239 412694014088 Bacterial SH3 domain; Region: SH3_3; pfam08239 412694014089 Bacterial SH3 domain; Region: SH3_3; pfam08239 412694014090 Bacterial SH3 domain; Region: SH3_3; pfam08239 412694014091 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 412694014092 NlpC/P60 family; Region: NLPC_P60; pfam00877 412694014093 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 412694014094 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 412694014095 Nucleoside recognition; Region: Gate; pfam07670 412694014096 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 412694014097 Uncharacterized conserved protein (DUF2215); Region: DUF2215; pfam10225 412694014098 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 412694014099 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 412694014100 DXD motif; other site 412694014101 BCCT family transporter; Region: BCCT; pfam02028 412694014102 Bacterial SH3 domain; Region: SH3_3; pfam08239 412694014103 Bacterial SH3 domain; Region: SH3_3; pfam08239 412694014104 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 412694014105 Protein of unknown function (DUF3910); Region: DUF3910; pfam13049 412694014106 Predicted membrane protein [Function unknown]; Region: COG4640 412694014107 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 412694014108 Double zinc ribbon; Region: DZR; pfam12773 412694014109 Double zinc ribbon; Region: DZR; pfam12773 412694014110 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 412694014111 SNF2 Helicase protein; Region: DUF3670; pfam12419 412694014112 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 412694014113 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 412694014114 ATP binding site [chemical binding]; other site 412694014115 putative Mg++ binding site [ion binding]; other site 412694014116 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 412694014117 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412694014118 nucleotide binding region [chemical binding]; other site 412694014119 ATP-binding site [chemical binding]; other site 412694014120 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 412694014121 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 412694014122 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 412694014123 ComK protein; Region: ComK; pfam06338 412694014124 Yip1 domain; Region: Yip1; cl17815 412694014125 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 412694014126 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 412694014127 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 412694014128 FtsX-like permease family; Region: FtsX; pfam02687 412694014129 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 412694014130 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 412694014131 Walker A/P-loop; other site 412694014132 ATP binding site [chemical binding]; other site 412694014133 Q-loop/lid; other site 412694014134 ABC transporter signature motif; other site 412694014135 Walker B; other site 412694014136 D-loop; other site 412694014137 H-loop/switch region; other site 412694014138 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 412694014139 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 412694014140 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 412694014141 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412694014142 non-specific DNA binding site [nucleotide binding]; other site 412694014143 salt bridge; other site 412694014144 sequence-specific DNA binding site [nucleotide binding]; other site 412694014145 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 412694014146 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694014147 putative substrate translocation pore; other site 412694014148 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 412694014149 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 412694014150 Protein of unknown function (DUF3919); Region: DUF3919; pfam13057 412694014151 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 412694014152 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412694014153 dimerization interface [polypeptide binding]; other site 412694014154 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694014155 dimer interface [polypeptide binding]; other site 412694014156 phosphorylation site [posttranslational modification] 412694014157 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694014158 ATP binding site [chemical binding]; other site 412694014159 Mg2+ binding site [ion binding]; other site 412694014160 G-X-G motif; other site 412694014161 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412694014162 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694014163 active site 412694014164 phosphorylation site [posttranslational modification] 412694014165 intermolecular recognition site; other site 412694014166 dimerization interface [polypeptide binding]; other site 412694014167 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412694014168 DNA binding site [nucleotide binding] 412694014169 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 412694014170 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 412694014171 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 412694014172 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 412694014173 active site 412694014174 P-loop; other site 412694014175 phosphorylation site [posttranslational modification] 412694014176 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 412694014177 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 412694014178 active site 412694014179 phosphorylation site [posttranslational modification] 412694014180 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 412694014181 HTH domain; Region: HTH_11; pfam08279 412694014182 HTH domain; Region: HTH_11; pfam08279 412694014183 PRD domain; Region: PRD; pfam00874 412694014184 PRD domain; Region: PRD; pfam00874 412694014185 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 412694014186 active site 412694014187 P-loop; other site 412694014188 phosphorylation site [posttranslational modification] 412694014189 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 412694014190 active site 412694014191 phosphorylation site [posttranslational modification] 412694014192 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 412694014193 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 412694014194 NAD binding site [chemical binding]; other site 412694014195 homodimer interface [polypeptide binding]; other site 412694014196 active site 412694014197 substrate binding site [chemical binding]; other site 412694014198 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 412694014199 catalytic triad [active] 412694014200 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 412694014201 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 412694014202 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 412694014203 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 412694014204 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 412694014205 active site 412694014206 Cupin domain; Region: Cupin_2; cl17218 412694014207 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 412694014208 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 412694014209 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 412694014210 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 412694014211 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 412694014212 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 412694014213 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 412694014214 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 412694014215 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 412694014216 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 412694014217 colanic acid exporter; Provisional; Region: PRK10459 412694014218 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 412694014219 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 412694014220 Bacterial sugar transferase; Region: Bac_transf; pfam02397 412694014221 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 412694014222 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 412694014223 active site 412694014224 tetramer interface; other site 412694014225 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 412694014226 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 412694014227 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 412694014228 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 412694014229 Chain length determinant protein; Region: Wzz; cl15801 412694014230 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 412694014231 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 412694014232 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 412694014233 rod shape-determining protein Mbl; Provisional; Region: PRK13928 412694014234 MreB and similar proteins; Region: MreB_like; cd10225 412694014235 nucleotide binding site [chemical binding]; other site 412694014236 Mg binding site [ion binding]; other site 412694014237 putative protofilament interaction site [polypeptide binding]; other site 412694014238 RodZ interaction site [polypeptide binding]; other site 412694014239 Stage III sporulation protein D; Region: SpoIIID; pfam12116 412694014240 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 412694014241 Peptidase family M23; Region: Peptidase_M23; pfam01551 412694014242 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 412694014243 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 412694014244 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 412694014245 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 412694014246 Walker A/P-loop; other site 412694014247 ATP binding site [chemical binding]; other site 412694014248 Q-loop/lid; other site 412694014249 ABC transporter signature motif; other site 412694014250 Walker B; other site 412694014251 D-loop; other site 412694014252 H-loop/switch region; other site 412694014253 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 412694014254 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412694014255 Walker A/P-loop; other site 412694014256 ATP binding site [chemical binding]; other site 412694014257 Q-loop/lid; other site 412694014258 ABC transporter signature motif; other site 412694014259 Walker B; other site 412694014260 D-loop; other site 412694014261 H-loop/switch region; other site 412694014262 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 412694014263 LytTr DNA-binding domain; Region: LytTR; pfam04397 412694014264 Stage II sporulation protein; Region: SpoIID; pfam08486 412694014265 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 412694014266 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 412694014267 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 412694014268 hinge; other site 412694014269 active site 412694014270 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 412694014271 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 412694014272 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 412694014273 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 412694014274 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 412694014275 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 412694014276 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 412694014277 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 412694014278 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 412694014279 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 412694014280 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 412694014281 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 412694014282 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 412694014283 NADH dehydrogenase subunit D; Provisional; Region: PRK12322 412694014284 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 412694014285 NADH dehydrogenase subunit C; Validated; Region: PRK07735 412694014286 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 412694014287 NADH dehydrogenase subunit B; Validated; Region: PRK06411 412694014288 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 412694014289 PAS domain; Region: PAS_9; pfam13426 412694014290 putative active site [active] 412694014291 heme pocket [chemical binding]; other site 412694014292 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 412694014293 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 412694014294 metal binding site [ion binding]; metal-binding site 412694014295 active site 412694014296 I-site; other site 412694014297 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 412694014298 Protein of unknown function (DUF975); Region: DUF975; cl10504 412694014299 Protein of unknown function (DUF975); Region: DUF975; cl10504 412694014300 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 412694014301 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 412694014302 gamma subunit interface [polypeptide binding]; other site 412694014303 epsilon subunit interface [polypeptide binding]; other site 412694014304 LBP interface [polypeptide binding]; other site 412694014305 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 412694014306 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 412694014307 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 412694014308 alpha subunit interaction interface [polypeptide binding]; other site 412694014309 Walker A motif; other site 412694014310 ATP binding site [chemical binding]; other site 412694014311 Walker B motif; other site 412694014312 inhibitor binding site; inhibition site 412694014313 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 412694014314 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 412694014315 core domain interface [polypeptide binding]; other site 412694014316 delta subunit interface [polypeptide binding]; other site 412694014317 epsilon subunit interface [polypeptide binding]; other site 412694014318 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 412694014319 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 412694014320 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 412694014321 beta subunit interaction interface [polypeptide binding]; other site 412694014322 Walker A motif; other site 412694014323 ATP binding site [chemical binding]; other site 412694014324 Walker B motif; other site 412694014325 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 412694014326 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 412694014327 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 412694014328 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 412694014329 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 412694014330 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 412694014331 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 412694014332 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 412694014333 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 412694014334 active site 412694014335 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 412694014336 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 412694014337 dimer interface [polypeptide binding]; other site 412694014338 active site 412694014339 glycine-pyridoxal phosphate binding site [chemical binding]; other site 412694014340 folate binding site [chemical binding]; other site 412694014341 hypothetical protein; Provisional; Region: PRK13690 412694014342 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 412694014343 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 412694014344 Low molecular weight phosphatase family; Region: LMWPc; cd00115 412694014345 active site 412694014346 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 412694014347 HPr interaction site; other site 412694014348 glycerol kinase (GK) interaction site [polypeptide binding]; other site 412694014349 active site 412694014350 phosphorylation site [posttranslational modification] 412694014351 Predicted membrane protein [Function unknown]; Region: COG2259 412694014352 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 412694014353 Predicted membrane protein [Function unknown]; Region: COG1971 412694014354 Domain of unknown function DUF; Region: DUF204; pfam02659 412694014355 Domain of unknown function DUF; Region: DUF204; pfam02659 412694014356 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 412694014357 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 412694014358 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 412694014359 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 412694014360 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 412694014361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694014362 S-adenosylmethionine binding site [chemical binding]; other site 412694014363 peptide chain release factor 1; Validated; Region: prfA; PRK00591 412694014364 This domain is found in peptide chain release factors; Region: PCRF; smart00937 412694014365 RF-1 domain; Region: RF-1; pfam00472 412694014366 thymidine kinase; Provisional; Region: PRK04296 412694014367 transcription termination factor Rho; Provisional; Region: rho; PRK09376 412694014368 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 412694014369 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 412694014370 RNA binding site [nucleotide binding]; other site 412694014371 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 412694014372 multimer interface [polypeptide binding]; other site 412694014373 Walker A motif; other site 412694014374 ATP binding site [chemical binding]; other site 412694014375 Walker B motif; other site 412694014376 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 412694014377 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 412694014378 putative active site [active] 412694014379 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 412694014380 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 412694014381 hinge; other site 412694014382 active site 412694014383 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 412694014384 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 412694014385 intersubunit interface [polypeptide binding]; other site 412694014386 active site 412694014387 zinc binding site [ion binding]; other site 412694014388 Na+ binding site [ion binding]; other site 412694014389 Response regulator receiver domain; Region: Response_reg; pfam00072 412694014390 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694014391 active site 412694014392 phosphorylation site [posttranslational modification] 412694014393 intermolecular recognition site; other site 412694014394 dimerization interface [polypeptide binding]; other site 412694014395 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 412694014396 CTP synthetase; Validated; Region: pyrG; PRK05380 412694014397 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 412694014398 Catalytic site [active] 412694014399 active site 412694014400 UTP binding site [chemical binding]; other site 412694014401 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 412694014402 active site 412694014403 putative oxyanion hole; other site 412694014404 catalytic triad [active] 412694014405 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 412694014406 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412694014407 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412694014408 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 412694014409 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 412694014410 FAD binding site [chemical binding]; other site 412694014411 homotetramer interface [polypeptide binding]; other site 412694014412 substrate binding pocket [chemical binding]; other site 412694014413 catalytic base [active] 412694014414 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 412694014415 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 412694014416 FAD binding site [chemical binding]; other site 412694014417 homotetramer interface [polypeptide binding]; other site 412694014418 substrate binding pocket [chemical binding]; other site 412694014419 catalytic base [active] 412694014420 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 412694014421 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 412694014422 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 412694014423 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 412694014424 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 412694014425 dimer interface [polypeptide binding]; other site 412694014426 active site 412694014427 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 412694014428 4Fe-4S binding domain; Region: Fer4; cl02805 412694014429 Cysteine-rich domain; Region: CCG; pfam02754 412694014430 Cysteine-rich domain; Region: CCG; pfam02754 412694014431 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 412694014432 PLD-like domain; Region: PLDc_2; pfam13091 412694014433 putative active site [active] 412694014434 catalytic site [active] 412694014435 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 412694014436 PLD-like domain; Region: PLDc_2; pfam13091 412694014437 putative active site [active] 412694014438 catalytic site [active] 412694014439 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 412694014440 Domain of unknown function (DUF4084); Region: DUF4084; pfam13321 412694014441 PAS domain S-box; Region: sensory_box; TIGR00229 412694014442 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 412694014443 putative active site [active] 412694014444 heme pocket [chemical binding]; other site 412694014445 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 412694014446 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 412694014447 metal binding site [ion binding]; metal-binding site 412694014448 active site 412694014449 I-site; other site 412694014450 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 412694014451 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 412694014452 non-specific DNA binding site [nucleotide binding]; other site 412694014453 salt bridge; other site 412694014454 sequence-specific DNA binding site [nucleotide binding]; other site 412694014455 Tetratricopeptide repeat; Region: TPR_12; pfam13424 412694014456 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 412694014457 TPR motif; other site 412694014458 binding surface 412694014459 TPR repeat; Region: TPR_11; pfam13414 412694014460 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 412694014461 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 412694014462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694014463 active site 412694014464 phosphorylation site [posttranslational modification] 412694014465 intermolecular recognition site; other site 412694014466 dimerization interface [polypeptide binding]; other site 412694014467 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 412694014468 DNA binding residues [nucleotide binding] 412694014469 dimerization interface [polypeptide binding]; other site 412694014470 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 412694014471 Histidine kinase; Region: HisKA_3; pfam07730 412694014472 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694014473 ATP binding site [chemical binding]; other site 412694014474 Mg2+ binding site [ion binding]; other site 412694014475 G-X-G motif; other site 412694014476 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 412694014477 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 412694014478 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 412694014479 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 412694014480 Walker A/P-loop; other site 412694014481 ATP binding site [chemical binding]; other site 412694014482 Q-loop/lid; other site 412694014483 ABC transporter signature motif; other site 412694014484 Walker B; other site 412694014485 D-loop; other site 412694014486 H-loop/switch region; other site 412694014487 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 412694014488 active site 412694014489 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 412694014490 Collagen binding domain; Region: Collagen_bind; pfam05737 412694014491 Collagen binding domain; Region: Collagen_bind; pfam05737 412694014492 Collagen binding domain; Region: Collagen_bind; pfam05737 412694014493 Collagen binding domain; Region: Collagen_bind; pfam05737 412694014494 Cna protein B-type domain; Region: Cna_B; pfam05738 412694014495 Cna protein B-type domain; Region: Cna_B; pfam05738 412694014496 Cna protein B-type domain; Region: Cna_B; pfam05738 412694014497 Cna protein B-type domain; Region: Cna_B; pfam05738 412694014498 Cna protein B-type domain; Region: Cna_B; pfam05738 412694014499 Cna protein B-type domain; Region: Cna_B; pfam05738 412694014500 Cna protein B-type domain; Region: Cna_B; pfam05738 412694014501 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 412694014502 Cna protein B-type domain; Region: Cna_B; pfam05738 412694014503 Cna protein B-type domain; Region: Cna_B; pfam05738 412694014504 Cna protein B-type domain; Region: Cna_B; pfam05738 412694014505 Cna protein B-type domain; Region: Cna_B; pfam05738 412694014506 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 412694014507 Cna protein B-type domain; Region: Cna_B; pfam05738 412694014508 Cna protein B-type domain; Region: Cna_B; pfam05738 412694014509 Cna protein B-type domain; Region: Cna_B; pfam05738 412694014510 Cna protein B-type domain; Region: Cna_B; pfam05738 412694014511 Cna protein B-type domain; Region: Cna_B; pfam05738 412694014512 Cna protein B-type domain; Region: Cna_B; pfam05738 412694014513 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 412694014514 Cna protein B-type domain; Region: Cna_B; pfam05738 412694014515 Cna protein B-type domain; Region: Cna_B; pfam05738 412694014516 Cna protein B-type domain; Region: Cna_B; pfam05738 412694014517 Cna protein B-type domain; Region: Cna_B; pfam05738 412694014518 Cna protein B-type domain; Region: Cna_B; pfam05738 412694014519 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 412694014520 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 412694014521 PA/protease or protease-like domain interface [polypeptide binding]; other site 412694014522 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 412694014523 Peptidase family M28; Region: Peptidase_M28; pfam04389 412694014524 metal binding site [ion binding]; metal-binding site 412694014525 RNA polymerase sigma factor; Provisional; Region: PRK12522 412694014526 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412694014527 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 412694014528 DNA binding residues [nucleotide binding] 412694014529 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 412694014530 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 412694014531 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 412694014532 active site 412694014533 HIGH motif; other site 412694014534 KMSK motif region; other site 412694014535 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 412694014536 tRNA binding surface [nucleotide binding]; other site 412694014537 anticodon binding site; other site 412694014538 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 412694014539 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 412694014540 putative dimer interface [polypeptide binding]; other site 412694014541 catalytic triad [active] 412694014542 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 412694014543 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 412694014544 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 412694014545 agmatinase; Region: agmatinase; TIGR01230 412694014546 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 412694014547 putative active site [active] 412694014548 Mn binding site [ion binding]; other site 412694014549 spermidine synthase; Provisional; Region: PRK00811 412694014550 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694014551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694014552 Major Facilitator Superfamily; Region: MFS_1; pfam07690 412694014553 putative substrate translocation pore; other site 412694014554 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 412694014555 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 412694014556 DNA binding residues [nucleotide binding] 412694014557 putative dimer interface [polypeptide binding]; other site 412694014558 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 412694014559 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 412694014560 active site 412694014561 catalytic site [active] 412694014562 metal binding site [ion binding]; metal-binding site 412694014563 dimer interface [polypeptide binding]; other site 412694014564 Transglycosylase; Region: Transgly; pfam00912 412694014565 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 412694014566 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 412694014567 YwhD family; Region: YwhD; pfam08741 412694014568 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 412694014569 Peptidase family M50; Region: Peptidase_M50; pfam02163 412694014570 active site 412694014571 putative substrate binding region [chemical binding]; other site 412694014572 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 412694014573 active site 1 [active] 412694014574 dimer interface [polypeptide binding]; other site 412694014575 hexamer interface [polypeptide binding]; other site 412694014576 active site 2 [active] 412694014577 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 412694014578 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 412694014579 Zn2+ binding site [ion binding]; other site 412694014580 Mg2+ binding site [ion binding]; other site 412694014581 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 412694014582 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 412694014583 intersubunit interface [polypeptide binding]; other site 412694014584 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 412694014585 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 412694014586 Walker A/P-loop; other site 412694014587 ATP binding site [chemical binding]; other site 412694014588 Q-loop/lid; other site 412694014589 ABC transporter signature motif; other site 412694014590 Walker B; other site 412694014591 D-loop; other site 412694014592 H-loop/switch region; other site 412694014593 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 412694014594 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 412694014595 ABC-ATPase subunit interface; other site 412694014596 dimer interface [polypeptide binding]; other site 412694014597 putative PBP binding regions; other site 412694014598 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 412694014599 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 412694014600 ABC-ATPase subunit interface; other site 412694014601 dimer interface [polypeptide binding]; other site 412694014602 putative PBP binding regions; other site 412694014603 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 412694014604 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 412694014605 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 412694014606 hypothetical protein; Provisional; Region: PRK12473 412694014607 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 412694014608 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 412694014609 putative heme peroxidase; Provisional; Region: PRK12276 412694014610 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 412694014611 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 412694014612 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 412694014613 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 412694014614 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 412694014615 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 412694014616 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 412694014617 Ion channel; Region: Ion_trans_2; pfam07885 412694014618 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 412694014619 TrkA-N domain; Region: TrkA_N; pfam02254 412694014620 TrkA-C domain; Region: TrkA_C; pfam02080 412694014621 putative uracil/xanthine transporter; Provisional; Region: PRK11412 412694014622 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 412694014623 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412694014624 motif II; other site 412694014625 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412694014626 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 412694014627 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 412694014628 ligand binding site [chemical binding]; other site 412694014629 active site 412694014630 UGI interface [polypeptide binding]; other site 412694014631 catalytic site [active] 412694014632 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 412694014633 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 412694014634 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 412694014635 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 412694014636 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 412694014637 Walker A/P-loop; other site 412694014638 ATP binding site [chemical binding]; other site 412694014639 Q-loop/lid; other site 412694014640 ABC transporter signature motif; other site 412694014641 Walker B; other site 412694014642 D-loop; other site 412694014643 H-loop/switch region; other site 412694014644 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 412694014645 active site 412694014646 catalytic triad [active] 412694014647 oxyanion hole [active] 412694014648 Transcriptional regulators [Transcription]; Region: PurR; COG1609 412694014649 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 412694014650 DNA binding site [nucleotide binding] 412694014651 domain linker motif; other site 412694014652 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 412694014653 putative dimerization interface [polypeptide binding]; other site 412694014654 putative ligand binding site [chemical binding]; other site 412694014655 Predicted membrane protein [Function unknown]; Region: COG2364 412694014656 homoserine dehydrogenase; Provisional; Region: PRK06349 412694014657 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 412694014658 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 412694014659 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 412694014660 homoserine O-succinyltransferase; Provisional; Region: PRK05368 412694014661 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 412694014662 proposed active site lysine [active] 412694014663 conserved cys residue [active] 412694014664 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06702 412694014665 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 412694014666 homodimer interface [polypeptide binding]; other site 412694014667 substrate-cofactor binding pocket; other site 412694014668 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412694014669 catalytic residue [active] 412694014670 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 412694014671 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412694014672 active site 412694014673 motif I; other site 412694014674 motif II; other site 412694014675 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 412694014676 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 412694014677 ligand binding site [chemical binding]; other site 412694014678 flexible hinge region; other site 412694014679 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 412694014680 azoreductase; Provisional; Region: PRK13556 412694014681 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 412694014682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694014683 active site 412694014684 phosphorylation site [posttranslational modification] 412694014685 intermolecular recognition site; other site 412694014686 dimerization interface [polypeptide binding]; other site 412694014687 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 412694014688 DNA binding residues [nucleotide binding] 412694014689 dimerization interface [polypeptide binding]; other site 412694014690 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 412694014691 GAF domain; Region: GAF; pfam01590 412694014692 GAF domain; Region: GAF_3; pfam13492 412694014693 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 412694014694 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 412694014695 Histidine kinase; Region: HisKA_3; pfam07730 412694014696 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 412694014697 ATP binding site [chemical binding]; other site 412694014698 Mg2+ binding site [ion binding]; other site 412694014699 G-X-G motif; other site 412694014700 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 412694014701 dimer interface [polypeptide binding]; other site 412694014702 substrate binding site [chemical binding]; other site 412694014703 ATP binding site [chemical binding]; other site 412694014704 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 412694014705 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 412694014706 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 412694014707 metal binding site [ion binding]; metal-binding site 412694014708 active site 412694014709 I-site; other site 412694014710 Protein of unknown function (DUF466); Region: DUF466; pfam04328 412694014711 carbon starvation protein A; Provisional; Region: PRK15015 412694014712 Carbon starvation protein CstA; Region: CstA; pfam02554 412694014713 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 412694014714 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 412694014715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694014716 active site 412694014717 phosphorylation site [posttranslational modification] 412694014718 intermolecular recognition site; other site 412694014719 dimerization interface [polypeptide binding]; other site 412694014720 LytTr DNA-binding domain; Region: LytTR; pfam04397 412694014721 benzoate transport; Region: 2A0115; TIGR00895 412694014722 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694014723 putative substrate translocation pore; other site 412694014724 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 412694014725 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 412694014726 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 412694014727 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 412694014728 Predicted membrane protein [Function unknown]; Region: COG2860 412694014729 UPF0126 domain; Region: UPF0126; pfam03458 412694014730 UPF0126 domain; Region: UPF0126; pfam03458 412694014731 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 412694014732 heme-binding site [chemical binding]; other site 412694014733 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 412694014734 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 412694014735 dimer interface [polypeptide binding]; other site 412694014736 putative CheW interface [polypeptide binding]; other site 412694014737 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 412694014738 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 412694014739 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 412694014740 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 412694014741 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 412694014742 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 412694014743 active site 412694014744 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 412694014745 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 412694014746 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 412694014747 ABC transporter; Region: ABC_tran_2; pfam12848 412694014748 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 412694014749 conserved hypothetical integral membrane protein; Region: TIGR03766 412694014750 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 412694014751 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 412694014752 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 412694014753 Ligand binding site; other site 412694014754 Putative Catalytic site; other site 412694014755 DXD motif; other site 412694014756 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 412694014757 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 412694014758 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 412694014759 Protein export membrane protein; Region: SecD_SecF; cl14618 412694014760 methionine sulfoxide reductase A; Provisional; Region: PRK14054 412694014761 methionine sulfoxide reductase B; Provisional; Region: PRK00222 412694014762 SelR domain; Region: SelR; pfam01641 412694014763 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 412694014764 antiholin-like protein LrgB; Provisional; Region: PRK04288 412694014765 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 412694014766 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 412694014767 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694014768 active site 412694014769 phosphorylation site [posttranslational modification] 412694014770 intermolecular recognition site; other site 412694014771 dimerization interface [polypeptide binding]; other site 412694014772 LytTr DNA-binding domain; Region: LytTR; pfam04397 412694014773 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 412694014774 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 412694014775 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 412694014776 Histidine kinase; Region: His_kinase; pfam06580 412694014777 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694014778 ATP binding site [chemical binding]; other site 412694014779 Mg2+ binding site [ion binding]; other site 412694014780 G-X-G motif; other site 412694014781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412694014782 benzoate transport; Region: 2A0115; TIGR00895 412694014783 putative substrate translocation pore; other site 412694014784 BCCT family transporter; Region: BCCT; pfam02028 412694014785 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 412694014786 active site 412694014787 dimer interface [polypeptide binding]; other site 412694014788 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 412694014789 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 412694014790 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 412694014791 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 412694014792 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412694014793 NAD(P) binding site [chemical binding]; other site 412694014794 active site 412694014795 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 412694014796 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 412694014797 UDP-glucose 4-epimerase; Region: PLN02240 412694014798 NAD binding site [chemical binding]; other site 412694014799 homodimer interface [polypeptide binding]; other site 412694014800 active site 412694014801 substrate binding site [chemical binding]; other site 412694014802 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 412694014803 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 412694014804 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 412694014805 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 412694014806 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 412694014807 ATP binding site [chemical binding]; other site 412694014808 Mg++ binding site [ion binding]; other site 412694014809 motif III; other site 412694014810 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412694014811 nucleotide binding region [chemical binding]; other site 412694014812 ATP-binding site [chemical binding]; other site 412694014813 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 412694014814 RNA binding site [nucleotide binding]; other site 412694014815 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 412694014816 Acyltransferase family; Region: Acyl_transf_3; pfam01757 412694014817 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 412694014818 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 412694014819 active site 412694014820 oligoendopeptidase F; Region: pepF; TIGR00181 412694014821 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 412694014822 active site 412694014823 Zn binding site [ion binding]; other site 412694014824 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412694014825 FeS/SAM binding site; other site 412694014826 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 412694014827 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 412694014828 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 412694014829 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 412694014830 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 412694014831 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 412694014832 protein binding site [polypeptide binding]; other site 412694014833 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 412694014834 YycH protein; Region: YycI; pfam09648 412694014835 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 412694014836 YycH protein; Region: YycH; pfam07435 412694014837 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 412694014838 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 412694014839 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412694014840 dimerization interface [polypeptide binding]; other site 412694014841 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 412694014842 putative active site [active] 412694014843 heme pocket [chemical binding]; other site 412694014844 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412694014845 dimer interface [polypeptide binding]; other site 412694014846 phosphorylation site [posttranslational modification] 412694014847 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412694014848 ATP binding site [chemical binding]; other site 412694014849 Mg2+ binding site [ion binding]; other site 412694014850 G-X-G motif; other site 412694014851 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 412694014852 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412694014853 active site 412694014854 phosphorylation site [posttranslational modification] 412694014855 intermolecular recognition site; other site 412694014856 dimerization interface [polypeptide binding]; other site 412694014857 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 412694014858 DNA binding site [nucleotide binding] 412694014859 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 412694014860 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 412694014861 GDP-binding site [chemical binding]; other site 412694014862 ACT binding site; other site 412694014863 IMP binding site; other site 412694014864 replicative DNA helicase; Provisional; Region: PRK05748 412694014865 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 412694014866 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 412694014867 Walker A motif; other site 412694014868 ATP binding site [chemical binding]; other site 412694014869 Walker B motif; other site 412694014870 DNA binding loops [nucleotide binding] 412694014871 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 412694014872 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 412694014873 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 412694014874 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 412694014875 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 412694014876 DHH family; Region: DHH; pfam01368 412694014877 DHHA1 domain; Region: DHHA1; pfam02272 412694014878 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 412694014879 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 412694014880 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 412694014881 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 412694014882 dimer interface [polypeptide binding]; other site 412694014883 ssDNA binding site [nucleotide binding]; other site 412694014884 tetramer (dimer of dimers) interface [polypeptide binding]; other site 412694014885 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 412694014886 GTP-binding protein YchF; Reviewed; Region: PRK09601 412694014887 YchF GTPase; Region: YchF; cd01900 412694014888 G1 box; other site 412694014889 GTP/Mg2+ binding site [chemical binding]; other site 412694014890 Switch I region; other site 412694014891 G2 box; other site 412694014892 Switch II region; other site 412694014893 G3 box; other site 412694014894 G4 box; other site 412694014895 G5 box; other site 412694014896 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 412694014897 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 412694014898 Mechanosensitive ion channel; Region: MS_channel; pfam00924 412694014899 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 412694014900 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 412694014901 ParB-like nuclease domain; Region: ParB; smart00470 412694014902 KorB domain; Region: KorB; pfam08535 412694014903 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 412694014904 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 412694014905 P-loop; other site 412694014906 Magnesium ion binding site [ion binding]; other site 412694014907 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 412694014908 Magnesium ion binding site [ion binding]; other site 412694014909 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 412694014910 ParB-like nuclease domain; Region: ParBc; pfam02195 412694014911 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 412694014912 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412694014913 S-adenosylmethionine binding site [chemical binding]; other site 412694014914 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 412694014915 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 412694014916 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 412694014917 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 412694014918 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 412694014919 trmE is a tRNA modification GTPase; Region: trmE; cd04164 412694014920 G1 box; other site 412694014921 GTP/Mg2+ binding site [chemical binding]; other site 412694014922 Switch I region; other site 412694014923 G2 box; other site 412694014924 Switch II region; other site 412694014925 G3 box; other site 412694014926 G4 box; other site 412694014927 G5 box; other site 412694014928 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 412694014929 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 412694014930 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 412694014931 G-X-X-G motif; other site 412694014932 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 412694014933 RxxxH motif; other site 412694014934 OxaA-like protein precursor; Validated; Region: PRK02944 412694014935 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 412694014936 ribonuclease P; Reviewed; Region: rnpA; PRK00499