-- dump date 20140618_204944 -- class Genbank::misc_feature -- table misc_feature_note -- id note 944547000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 944547000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 944547000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 944547000004 Walker A motif; other site 944547000005 ATP binding site [chemical binding]; other site 944547000006 Walker B motif; other site 944547000007 arginine finger; other site 944547000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 944547000009 DnaA box-binding interface [nucleotide binding]; other site 944547000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 944547000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 944547000012 putative DNA binding surface [nucleotide binding]; other site 944547000013 dimer interface [polypeptide binding]; other site 944547000014 beta-clamp/clamp loader binding surface; other site 944547000015 beta-clamp/translesion DNA polymerase binding surface; other site 944547000016 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 944547000017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547000018 Mg2+ binding site [ion binding]; other site 944547000019 G-X-G motif; other site 944547000020 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 944547000021 anchoring element; other site 944547000022 dimer interface [polypeptide binding]; other site 944547000023 ATP binding site [chemical binding]; other site 944547000024 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 944547000025 active site 944547000026 putative metal-binding site [ion binding]; other site 944547000027 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 944547000028 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 944547000029 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 944547000030 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 944547000031 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 944547000032 Predicted membrane protein [Function unknown]; Region: COG1238 944547000033 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 944547000034 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 944547000035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 944547000036 Walker A motif; other site 944547000037 ATP binding site [chemical binding]; other site 944547000038 Walker B motif; other site 944547000039 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 944547000040 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 944547000041 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 944547000042 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 944547000043 Walker A motif; other site 944547000044 ATP binding site [chemical binding]; other site 944547000045 Walker B motif; other site 944547000046 arginine finger; other site 944547000047 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 944547000048 NifT/FixU protein; Region: NifT; cl02351 944547000049 L-aspartate oxidase; Provisional; Region: PRK06175 944547000050 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 944547000051 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 944547000052 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 944547000053 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 944547000054 active site 944547000055 catalytic tetrad [active] 944547000056 TOBE domain; Region: TOBE; cl01440 944547000057 TOBE domain; Region: TOBE; cl01440 944547000058 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 944547000059 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 944547000060 active site 944547000061 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 944547000062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 944547000063 dimer interface [polypeptide binding]; other site 944547000064 conserved gate region; other site 944547000065 putative PBP binding loops; other site 944547000066 ABC-ATPase subunit interface; other site 944547000067 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 944547000068 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 944547000069 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 944547000070 Moco binding site; other site 944547000071 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944547000072 S-adenosylmethionine binding site [chemical binding]; other site 944547000073 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 944547000074 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 944547000075 Walker A/P-loop; other site 944547000076 ATP binding site [chemical binding]; other site 944547000077 Q-loop/lid; other site 944547000078 ABC transporter signature motif; other site 944547000079 Walker B; other site 944547000080 D-loop; other site 944547000081 H-loop/switch region; other site 944547000082 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 944547000083 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 944547000084 ABC-ATPase subunit interface; other site 944547000085 dimer interface [polypeptide binding]; other site 944547000086 putative PBP binding regions; other site 944547000087 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 944547000088 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 944547000089 putative metal binding site [ion binding]; other site 944547000090 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 944547000091 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 944547000092 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 944547000093 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 944547000094 Walker A/P-loop; other site 944547000095 ATP binding site [chemical binding]; other site 944547000096 Q-loop/lid; other site 944547000097 ABC transporter signature motif; other site 944547000098 Walker B; other site 944547000099 D-loop; other site 944547000100 H-loop/switch region; other site 944547000101 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 944547000102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 944547000103 dimer interface [polypeptide binding]; other site 944547000104 conserved gate region; other site 944547000105 putative PBP binding loops; other site 944547000106 ABC-ATPase subunit interface; other site 944547000107 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 944547000108 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 944547000109 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 944547000110 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 944547000111 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 944547000112 molybdenum-pterin binding domain; Region: Mop; TIGR00638 944547000113 molybdenum-pterin binding domain; Region: Mop; TIGR00638 944547000114 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 944547000115 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 944547000116 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 944547000117 MoFe protein beta/alpha subunit interactions; other site 944547000118 Beta subunit P cluster binding residues; other site 944547000119 MoFe protein beta subunit/Fe protein contacts; other site 944547000120 MoFe protein dimer/ dimer interactions; other site 944547000121 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 944547000122 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 944547000123 MoFe protein alpha/beta subunit interactions; other site 944547000124 Alpha subunit P cluster binding residues; other site 944547000125 FeMoco binding residues [chemical binding]; other site 944547000126 MoFe protein alpha subunit/Fe protein contacts; other site 944547000127 MoFe protein dimer/ dimer interactions; other site 944547000128 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 944547000129 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 944547000130 Nucleotide-binding sites [chemical binding]; other site 944547000131 Walker A motif; other site 944547000132 Switch I region of nucleotide binding site; other site 944547000133 Fe4S4 binding sites [ion binding]; other site 944547000134 Switch II region of nucleotide binding site; other site 944547000135 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 944547000136 Predicted membrane protein [Function unknown]; Region: COG3174 944547000137 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 944547000138 PAS domain S-box; Region: sensory_box; TIGR00229 944547000139 PAS domain S-box; Region: sensory_box; TIGR00229 944547000140 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547000141 putative active site [active] 944547000142 heme pocket [chemical binding]; other site 944547000143 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547000144 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547000145 dimer interface [polypeptide binding]; other site 944547000146 phosphorylation site [posttranslational modification] 944547000147 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547000148 ATP binding site [chemical binding]; other site 944547000149 Mg2+ binding site [ion binding]; other site 944547000150 G-X-G motif; other site 944547000151 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 944547000152 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 944547000153 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 944547000154 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 944547000155 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 944547000156 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 944547000157 catalytic loop [active] 944547000158 iron binding site [ion binding]; other site 944547000159 NifZ domain; Region: NifZ; pfam04319 944547000160 Nitrogen fixation protein NifW; Region: NifW; cl03935 944547000161 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 944547000162 Protein of unknown function, DUF269; Region: DUF269; cl03973 944547000163 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 944547000164 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 944547000165 NADPH bind site [chemical binding]; other site 944547000166 putative FMN binding site [chemical binding]; other site 944547000167 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 944547000168 putative FMN binding site [chemical binding]; other site 944547000169 NADPH bind site [chemical binding]; other site 944547000170 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 944547000171 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 944547000172 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 944547000173 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 944547000174 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 944547000175 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 944547000176 ethanolamine permease; Region: 2A0305; TIGR00908 944547000177 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 944547000178 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 944547000179 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 944547000180 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 944547000181 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 944547000182 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 944547000183 Predicted transcriptional regulators [Transcription]; Region: COG1733 944547000184 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 944547000185 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 944547000186 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 944547000187 TPR motif; other site 944547000188 binding surface 944547000189 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 944547000190 NifU-like domain; Region: NifU; cl00484 944547000191 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 944547000192 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 944547000193 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 944547000194 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 944547000195 Transcriptional regulator [Transcription]; Region: LysR; COG0583 944547000196 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 944547000197 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 944547000198 dimerization interface [polypeptide binding]; other site 944547000199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 944547000200 Major Facilitator Superfamily; Region: MFS_1; pfam07690 944547000201 putative substrate translocation pore; other site 944547000202 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 944547000203 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 944547000204 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 944547000205 FeS/SAM binding site; other site 944547000206 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 944547000207 Putative addiction module component; Region: Unstab_antitox; pfam09720 944547000208 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 944547000209 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 944547000210 active site 944547000211 catalytic residues [active] 944547000212 metal binding site [ion binding]; metal-binding site 944547000213 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 944547000214 Leucine rich repeat; Region: LRR_8; pfam13855 944547000215 Leucine rich repeat; Region: LRR_8; pfam13855 944547000216 NifQ; Region: NifQ; pfam04891 944547000217 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944547000218 dimer interface [polypeptide binding]; other site 944547000219 putative CheW interface [polypeptide binding]; other site 944547000220 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547000221 PAS fold; Region: PAS_3; pfam08447 944547000222 putative active site [active] 944547000223 heme pocket [chemical binding]; other site 944547000224 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 944547000225 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 944547000226 active site 944547000227 adenylosuccinate lyase; Provisional; Region: PRK08470 944547000228 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 944547000229 tetramer interface [polypeptide binding]; other site 944547000230 active site 944547000231 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 944547000232 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08447 944547000233 ATP cone domain; Region: ATP-cone; pfam03477 944547000234 Class I ribonucleotide reductase; Region: RNR_I; cd01679 944547000235 active site 944547000236 dimer interface [polypeptide binding]; other site 944547000237 catalytic residues [active] 944547000238 effector binding site; other site 944547000239 R2 peptide binding site; other site 944547000240 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 944547000241 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 944547000242 dimer interface [polypeptide binding]; other site 944547000243 putative radical transfer pathway; other site 944547000244 diiron center [ion binding]; other site 944547000245 tyrosyl radical; other site 944547000246 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 944547000247 active site 944547000248 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 944547000249 dimer interface [polypeptide binding]; other site 944547000250 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 944547000251 metal binding site [ion binding]; metal-binding site 944547000252 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 944547000253 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 944547000254 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 944547000255 putative active site [active] 944547000256 putative metal binding residues [ion binding]; other site 944547000257 signature motif; other site 944547000258 putative dimer interface [polypeptide binding]; other site 944547000259 putative phosphate binding site [ion binding]; other site 944547000260 hydroxylamine reductase; Provisional; Region: PRK12310 944547000261 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 944547000262 ACS interaction site; other site 944547000263 CODH interaction site; other site 944547000264 metal cluster binding site [ion binding]; other site 944547000265 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 944547000266 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 944547000267 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 944547000268 ligand binding site [chemical binding]; other site 944547000269 Uncharacterized conserved protein [Function unknown]; Region: COG3743 944547000270 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 944547000271 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 944547000272 NADP binding site [chemical binding]; other site 944547000273 dimer interface [polypeptide binding]; other site 944547000274 Predicted transcriptional regulators [Transcription]; Region: COG1733 944547000275 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 944547000276 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 944547000277 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 944547000278 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 944547000279 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 944547000280 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 944547000281 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 944547000282 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 944547000283 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 944547000284 GatB domain; Region: GatB_Yqey; smart00845 944547000285 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 944547000286 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 944547000287 FAD binding domain; Region: FAD_binding_4; pfam01565 944547000288 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 944547000289 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 944547000290 DctM-like transporters; Region: DctM; pfam06808 944547000291 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 944547000292 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 944547000293 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 944547000294 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 944547000295 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 944547000296 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 944547000297 dimer interaction site [polypeptide binding]; other site 944547000298 substrate-binding tunnel; other site 944547000299 active site 944547000300 catalytic site [active] 944547000301 substrate binding site [chemical binding]; other site 944547000302 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 944547000303 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 944547000304 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 944547000305 FAD binding site [chemical binding]; other site 944547000306 homotetramer interface [polypeptide binding]; other site 944547000307 substrate binding pocket [chemical binding]; other site 944547000308 catalytic base [active] 944547000309 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 944547000310 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 944547000311 4Fe-4S binding domain; Region: Fer4; cl02805 944547000312 Cysteine-rich domain; Region: CCG; pfam02754 944547000313 Cysteine-rich domain; Region: CCG; pfam02754 944547000314 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 944547000315 Ligand binding site [chemical binding]; other site 944547000316 Electron transfer flavoprotein domain; Region: ETF; pfam01012 944547000317 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 944547000318 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 944547000319 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 944547000320 thiopurine S-methyltransferase, Se/Te detoxification family; Region: TMPT_Se_Te; TIGR03840 944547000321 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 944547000322 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 944547000323 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 944547000324 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 944547000325 CoenzymeA binding site [chemical binding]; other site 944547000326 subunit interaction site [polypeptide binding]; other site 944547000327 PHB binding site; other site 944547000328 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 944547000329 active site 944547000330 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 944547000331 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 944547000332 putative acyltransferase; Provisional; Region: PRK05790 944547000333 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 944547000334 dimer interface [polypeptide binding]; other site 944547000335 active site 944547000336 PAS fold; Region: PAS_4; pfam08448 944547000337 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547000338 putative active site [active] 944547000339 heme pocket [chemical binding]; other site 944547000340 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547000341 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547000342 ATP binding site [chemical binding]; other site 944547000343 G-X-G motif; other site 944547000344 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547000345 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547000346 active site 944547000347 phosphorylation site [posttranslational modification] 944547000348 intermolecular recognition site; other site 944547000349 dimerization interface [polypeptide binding]; other site 944547000350 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 944547000351 DNA binding site [nucleotide binding] 944547000352 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547000353 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547000354 active site 944547000355 phosphorylation site [posttranslational modification] 944547000356 intermolecular recognition site; other site 944547000357 dimerization interface [polypeptide binding]; other site 944547000358 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 944547000359 DNA binding site [nucleotide binding] 944547000360 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 944547000361 PAS fold; Region: PAS_4; pfam08448 944547000362 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547000363 putative active site [active] 944547000364 heme pocket [chemical binding]; other site 944547000365 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547000366 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 944547000367 ATP binding site [chemical binding]; other site 944547000368 G-X-G motif; other site 944547000369 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 944547000370 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 944547000371 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 944547000372 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 944547000373 Cysteine-rich domain; Region: CCG; pfam02754 944547000374 Cysteine-rich domain; Region: CCG; pfam02754 944547000375 Methyltransferase domain; Region: Methyltransf_25; pfam13649 944547000376 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 944547000377 catalytic motif [active] 944547000378 Zn binding site [ion binding]; other site 944547000379 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 944547000380 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 944547000381 carboxyltransferase (CT) interaction site; other site 944547000382 biotinylation site [posttranslational modification]; other site 944547000383 biotin carboxylase; Validated; Region: PRK08462 944547000384 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 944547000385 ATP-grasp domain; Region: ATP-grasp_4; cl17255 944547000386 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 944547000387 helicase 45; Provisional; Region: PTZ00424 944547000388 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 944547000389 ATP binding site [chemical binding]; other site 944547000390 Mg++ binding site [ion binding]; other site 944547000391 motif III; other site 944547000392 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 944547000393 nucleotide binding region [chemical binding]; other site 944547000394 ATP-binding site [chemical binding]; other site 944547000395 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 944547000396 Domain of unknown function (DUF947); Region: DUF947; pfam06102 944547000397 Membrane transport protein; Region: Mem_trans; cl09117 944547000398 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 944547000399 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 944547000400 active site 944547000401 dimer interface [polypeptide binding]; other site 944547000402 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 944547000403 Ligand Binding Site [chemical binding]; other site 944547000404 Molecular Tunnel; other site 944547000405 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 944547000406 FMN binding site [chemical binding]; other site 944547000407 dimer interface [polypeptide binding]; other site 944547000408 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 944547000409 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 944547000410 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 944547000411 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 944547000412 catalytic loop [active] 944547000413 iron binding site [ion binding]; other site 944547000414 L-aspartate oxidase; Provisional; Region: PRK06175 944547000415 succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812 944547000416 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 944547000417 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 944547000418 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 944547000419 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 944547000420 putative active site [active] 944547000421 PhoH-like protein; Region: PhoH; pfam02562 944547000422 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 944547000423 recombination factor protein RarA; Reviewed; Region: PRK13342 944547000424 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 944547000425 Walker A motif; other site 944547000426 ATP binding site [chemical binding]; other site 944547000427 Walker B motif; other site 944547000428 arginine finger; other site 944547000429 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 944547000430 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 944547000431 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 944547000432 RNA binding surface [nucleotide binding]; other site 944547000433 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 944547000434 active site 944547000435 KpsF/GutQ family protein; Region: kpsF; TIGR00393 944547000436 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 944547000437 putative active site [active] 944547000438 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 944547000439 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 944547000440 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 944547000441 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 944547000442 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 944547000443 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 944547000444 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 944547000445 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 944547000446 substrate binding site [chemical binding]; other site 944547000447 glutamase interaction surface [polypeptide binding]; other site 944547000448 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 944547000449 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 944547000450 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14462 944547000451 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 944547000452 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 944547000453 active site 944547000454 HIGH motif; other site 944547000455 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 944547000456 active site 944547000457 KMSKS motif; other site 944547000458 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 944547000459 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547000460 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547000461 active site 944547000462 phosphorylation site [posttranslational modification] 944547000463 intermolecular recognition site; other site 944547000464 dimerization interface [polypeptide binding]; other site 944547000465 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 944547000466 DNA binding site [nucleotide binding] 944547000467 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547000468 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547000469 dimer interface [polypeptide binding]; other site 944547000470 phosphorylation site [posttranslational modification] 944547000471 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547000472 ATP binding site [chemical binding]; other site 944547000473 Mg2+ binding site [ion binding]; other site 944547000474 G-X-G motif; other site 944547000475 YtkA-like; Region: YtkA; pfam13115 944547000476 Outer membrane efflux protein; Region: OEP; pfam02321 944547000477 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 944547000478 HlyD family secretion protein; Region: HlyD_3; pfam13437 944547000479 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 944547000480 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 944547000481 Uncharacterized conserved protein [Function unknown]; Region: COG2353 944547000482 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 944547000483 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_5; cd13145 944547000484 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 944547000485 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 944547000486 DNA binding residues [nucleotide binding] 944547000487 Isochorismatase family; Region: Isochorismatase; pfam00857 944547000488 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 944547000489 catalytic triad [active] 944547000490 conserved cis-peptide bond; other site 944547000491 homoserine dehydrogenase; Provisional; Region: PRK06349 944547000492 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 944547000493 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 944547000494 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 944547000495 aspartate aminotransferase; Provisional; Region: PRK08636 944547000496 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 944547000497 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944547000498 homodimer interface [polypeptide binding]; other site 944547000499 catalytic residue [active] 944547000500 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 944547000501 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 944547000502 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 944547000503 Predicted methyltransferases [General function prediction only]; Region: COG0313 944547000504 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 944547000505 putative SAM binding site [chemical binding]; other site 944547000506 putative homodimer interface [polypeptide binding]; other site 944547000507 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 944547000508 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 944547000509 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 944547000510 prenyltransferase; Reviewed; Region: ubiA; PRK12874 944547000511 UbiA prenyltransferase family; Region: UbiA; pfam01040 944547000512 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 944547000513 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 944547000514 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 944547000515 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 944547000516 Walker A motif; other site 944547000517 ATP binding site [chemical binding]; other site 944547000518 Walker B motif; other site 944547000519 Bacterial SH3 domain; Region: SH3_3; cl17532 944547000520 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 944547000521 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 944547000522 ATP-grasp domain; Region: ATP-grasp; pfam02222 944547000523 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 944547000524 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 944547000525 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 944547000526 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 944547000527 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 944547000528 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 944547000529 CoA-binding site [chemical binding]; other site 944547000530 ATP-binding [chemical binding]; other site 944547000531 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 944547000532 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 944547000533 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 944547000534 dimerization interface [polypeptide binding]; other site 944547000535 putative ATP binding site [chemical binding]; other site 944547000536 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 944547000537 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 944547000538 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 944547000539 Pirin-related protein [General function prediction only]; Region: COG1741 944547000540 Pirin; Region: Pirin; pfam02678 944547000541 Predicted flavoprotein [General function prediction only]; Region: COG0431 944547000542 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 944547000543 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 944547000544 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 944547000545 putative active site [active] 944547000546 metal binding site [ion binding]; metal-binding site 944547000547 Uncharacterized conserved protein [Function unknown]; Region: COG2353 944547000548 MarR family; Region: MarR_2; cl17246 944547000549 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 944547000550 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 944547000551 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 944547000552 catalytic residue [active] 944547000553 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12293 944547000554 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 944547000555 motif 1; other site 944547000556 dimer interface [polypeptide binding]; other site 944547000557 active site 944547000558 motif 2; other site 944547000559 motif 3; other site 944547000560 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 944547000561 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 944547000562 GDP-binding site [chemical binding]; other site 944547000563 ACT binding site; other site 944547000564 IMP binding site; other site 944547000565 Protein of unknown function (DUF507); Region: DUF507; pfam04368 944547000566 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 944547000567 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 944547000568 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 944547000569 catalytic site [active] 944547000570 subunit interface [polypeptide binding]; other site 944547000571 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 944547000572 tetramer interfaces [polypeptide binding]; other site 944547000573 binuclear metal-binding site [ion binding]; other site 944547000574 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547000575 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547000576 active site 944547000577 dimerization interface [polypeptide binding]; other site 944547000578 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 944547000579 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 944547000580 substrate binding site; other site 944547000581 dimer interface; other site 944547000582 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 944547000583 homotrimer interaction site [polypeptide binding]; other site 944547000584 zinc binding site [ion binding]; other site 944547000585 CDP-binding sites; other site 944547000586 HDOD domain; Region: HDOD; pfam08668 944547000587 ThiC family; Region: ThiC; pfam01964 944547000588 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 944547000589 Domain of unknown function DUF59; Region: DUF59; cl00941 944547000590 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 944547000591 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 944547000592 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 944547000593 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 944547000594 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 944547000595 metal binding site [ion binding]; metal-binding site 944547000596 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 944547000597 SPFH domain / Band 7 family; Region: Band_7; pfam01145 944547000598 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 944547000599 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 944547000600 homodimer interface [polypeptide binding]; other site 944547000601 substrate-cofactor binding pocket; other site 944547000602 catalytic residue [active] 944547000603 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 944547000604 dimerization interface [polypeptide binding]; other site 944547000605 active site 944547000606 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944547000607 S-adenosylmethionine binding site [chemical binding]; other site 944547000608 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 944547000609 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 944547000610 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 944547000611 substrate binding pocket [chemical binding]; other site 944547000612 dimer interface [polypeptide binding]; other site 944547000613 inhibitor binding site; inhibition site 944547000614 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 944547000615 B12 binding site [chemical binding]; other site 944547000616 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 944547000617 Predicted membrane protein [Function unknown]; Region: COG2259 944547000618 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 944547000619 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 944547000620 dimer interface [polypeptide binding]; other site 944547000621 active site 944547000622 metal binding site [ion binding]; metal-binding site 944547000623 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 944547000624 NMT1/THI5 like; Region: NMT1; pfam09084 944547000625 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 944547000626 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 944547000627 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 944547000628 substrate binding pocket [chemical binding]; other site 944547000629 membrane-bound complex binding site; other site 944547000630 hinge residues; other site 944547000631 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547000632 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547000633 dimer interface [polypeptide binding]; other site 944547000634 phosphorylation site [posttranslational modification] 944547000635 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547000636 ATP binding site [chemical binding]; other site 944547000637 Mg2+ binding site [ion binding]; other site 944547000638 G-X-G motif; other site 944547000639 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 944547000640 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 944547000641 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 944547000642 S-ribosylhomocysteinase; Provisional; Region: PRK02260 944547000643 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 944547000644 AAA ATPase domain; Region: AAA_15; pfam13175 944547000645 Walker A/P-loop; other site 944547000646 ATP binding site [chemical binding]; other site 944547000647 Protein of unknown function (DUF1439); Region: DUF1439; cl06345 944547000648 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 944547000649 Permease; Region: Permease; pfam02405 944547000650 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 944547000651 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 944547000652 Walker A/P-loop; other site 944547000653 ATP binding site [chemical binding]; other site 944547000654 Q-loop/lid; other site 944547000655 ABC transporter signature motif; other site 944547000656 Walker B; other site 944547000657 D-loop; other site 944547000658 H-loop/switch region; other site 944547000659 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 944547000660 mce related protein; Region: MCE; pfam02470 944547000661 Protein of unknown function (DUF330); Region: DUF330; cl01135 944547000662 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 944547000663 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 944547000664 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 944547000665 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 944547000666 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 944547000667 TPP-binding site [chemical binding]; other site 944547000668 putative dimer interface [polypeptide binding]; other site 944547000669 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 944547000670 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 944547000671 dimer interface [polypeptide binding]; other site 944547000672 PYR/PP interface [polypeptide binding]; other site 944547000673 TPP binding site [chemical binding]; other site 944547000674 substrate binding site [chemical binding]; other site 944547000675 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 944547000676 pyruvate flavodoxin oxidoreductase subunit delta; Reviewed; Region: porD; PRK09625 944547000677 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 944547000678 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 944547000679 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 944547000680 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 944547000681 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 944547000682 motif II; other site 944547000683 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 944547000684 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 944547000685 peptide binding site [polypeptide binding]; other site 944547000686 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 944547000687 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 944547000688 23S rRNA interface [nucleotide binding]; other site 944547000689 L3 interface [polypeptide binding]; other site 944547000690 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547000691 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547000692 dimer interface [polypeptide binding]; other site 944547000693 phosphorylation site [posttranslational modification] 944547000694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547000695 ATP binding site [chemical binding]; other site 944547000696 Mg2+ binding site [ion binding]; other site 944547000697 G-X-G motif; other site 944547000698 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547000699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547000700 active site 944547000701 phosphorylation site [posttranslational modification] 944547000702 intermolecular recognition site; other site 944547000703 dimerization interface [polypeptide binding]; other site 944547000704 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 944547000705 DNA binding site [nucleotide binding] 944547000706 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 944547000707 PhoU domain; Region: PhoU; pfam01895 944547000708 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 944547000709 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 944547000710 Walker A/P-loop; other site 944547000711 ATP binding site [chemical binding]; other site 944547000712 Q-loop/lid; other site 944547000713 ABC transporter signature motif; other site 944547000714 Walker B; other site 944547000715 D-loop; other site 944547000716 H-loop/switch region; other site 944547000717 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 944547000718 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 944547000719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 944547000720 dimer interface [polypeptide binding]; other site 944547000721 conserved gate region; other site 944547000722 putative PBP binding loops; other site 944547000723 ABC-ATPase subunit interface; other site 944547000724 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 944547000725 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 944547000726 dimer interface [polypeptide binding]; other site 944547000727 conserved gate region; other site 944547000728 putative PBP binding loops; other site 944547000729 ABC-ATPase subunit interface; other site 944547000730 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 944547000731 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 944547000732 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547000733 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547000734 metal binding site [ion binding]; metal-binding site 944547000735 active site 944547000736 I-site; other site 944547000737 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 944547000738 peptide chain release factor 1; Validated; Region: prfA; PRK00591 944547000739 This domain is found in peptide chain release factors; Region: PCRF; smart00937 944547000740 RF-1 domain; Region: RF-1; pfam00472 944547000741 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 944547000742 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14324 944547000743 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 944547000744 active site 944547000745 substrate binding site [chemical binding]; other site 944547000746 metal binding site [ion binding]; metal-binding site 944547000747 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 944547000748 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 944547000749 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 944547000750 substrate binding site [chemical binding]; other site 944547000751 ligand binding site [chemical binding]; other site 944547000752 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 944547000753 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 944547000754 GTP binding site; other site 944547000755 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 944547000756 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 944547000757 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 944547000758 23S rRNA binding site [nucleotide binding]; other site 944547000759 L21 binding site [polypeptide binding]; other site 944547000760 L13 binding site [polypeptide binding]; other site 944547000761 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 944547000762 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 944547000763 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 944547000764 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 944547000765 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 944547000766 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 944547000767 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 944547000768 active site 944547000769 dimer interface [polypeptide binding]; other site 944547000770 motif 1; other site 944547000771 motif 2; other site 944547000772 motif 3; other site 944547000773 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 944547000774 anticodon binding site; other site 944547000775 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 944547000776 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 944547000777 Domain of unknown function (DUF814); Region: DUF814; pfam05670 944547000778 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 944547000779 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 944547000780 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 944547000781 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 944547000782 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 944547000783 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 944547000784 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 944547000785 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 944547000786 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 944547000787 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 944547000788 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 944547000789 tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723 944547000790 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 944547000791 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 944547000792 putative rRNA binding site [nucleotide binding]; other site 944547000793 Uncharacterized conserved protein [Function unknown]; Region: COG0062 944547000794 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 944547000795 putative substrate binding site [chemical binding]; other site 944547000796 putative ATP binding site [chemical binding]; other site 944547000797 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 944547000798 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 944547000799 ThiS interaction site; other site 944547000800 putative active site [active] 944547000801 tetramer interface [polypeptide binding]; other site 944547000802 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 944547000803 AzlC protein; Region: AzlC; cl00570 944547000804 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 944547000805 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 944547000806 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 944547000807 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 944547000808 Helix-turn-helix domain; Region: HTH_38; pfam13936 944547000809 Homeodomain-like domain; Region: HTH_32; pfam13565 944547000810 Integrase core domain; Region: rve; pfam00665 944547000811 Integrase core domain; Region: rve_3; cl15866 944547000812 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 944547000813 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 944547000814 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 944547000815 active site 944547000816 catalytic residues [active] 944547000817 metal binding site [ion binding]; metal-binding site 944547000818 homodimer binding site [polypeptide binding]; other site 944547000819 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 944547000820 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 944547000821 carboxyltransferase (CT) interaction site; other site 944547000822 biotinylation site [posttranslational modification]; other site 944547000823 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277 944547000824 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 944547000825 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 944547000826 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 944547000827 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 944547000828 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 944547000829 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 944547000830 Leucyl/phenylalanyl-tRNA protein transferase; Region: Leu_Phe_trans; cl17317 944547000831 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 944547000832 PLD-like domain; Region: PLDc_2; pfam13091 944547000833 putative homodimer interface [polypeptide binding]; other site 944547000834 putative active site [active] 944547000835 catalytic site [active] 944547000836 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 944547000837 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 944547000838 ATP binding site [chemical binding]; other site 944547000839 putative Mg++ binding site [ion binding]; other site 944547000840 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 944547000841 nucleotide binding region [chemical binding]; other site 944547000842 ATP-binding site [chemical binding]; other site 944547000843 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 944547000844 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 944547000845 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 944547000846 substrate binding pocket [chemical binding]; other site 944547000847 membrane-bound complex binding site; other site 944547000848 hinge residues; other site 944547000849 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 944547000850 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 944547000851 substrate binding pocket [chemical binding]; other site 944547000852 membrane-bound complex binding site; other site 944547000853 hinge residues; other site 944547000854 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547000855 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547000856 dimer interface [polypeptide binding]; other site 944547000857 phosphorylation site [posttranslational modification] 944547000858 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547000859 ATP binding site [chemical binding]; other site 944547000860 Mg2+ binding site [ion binding]; other site 944547000861 G-X-G motif; other site 944547000862 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547000863 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547000864 active site 944547000865 phosphorylation site [posttranslational modification] 944547000866 intermolecular recognition site; other site 944547000867 dimerization interface [polypeptide binding]; other site 944547000868 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 944547000869 DNA binding site [nucleotide binding] 944547000870 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 944547000871 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 944547000872 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 944547000873 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 944547000874 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 944547000875 Walker A/P-loop; other site 944547000876 ATP binding site [chemical binding]; other site 944547000877 Q-loop/lid; other site 944547000878 ABC transporter signature motif; other site 944547000879 Walker B; other site 944547000880 D-loop; other site 944547000881 H-loop/switch region; other site 944547000882 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 944547000883 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 944547000884 E3 interaction surface; other site 944547000885 lipoyl attachment site [posttranslational modification]; other site 944547000886 HlyD family secretion protein; Region: HlyD_3; pfam13437 944547000887 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 944547000888 metal ion-dependent adhesion site (MIDAS); other site 944547000889 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547000890 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 944547000891 dimer interface [polypeptide binding]; other site 944547000892 phosphorylation site [posttranslational modification] 944547000893 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547000894 ATP binding site [chemical binding]; other site 944547000895 Mg2+ binding site [ion binding]; other site 944547000896 G-X-G motif; other site 944547000897 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 944547000898 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 944547000899 TPP-binding site [chemical binding]; other site 944547000900 dimer interface [polypeptide binding]; other site 944547000901 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 944547000902 PYR/PP interface [polypeptide binding]; other site 944547000903 dimer interface [polypeptide binding]; other site 944547000904 TPP binding site [chemical binding]; other site 944547000905 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 944547000906 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 944547000907 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; Region: 2-Hacid_dh_C; pfam02826 944547000908 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 944547000909 LrgA family; Region: LrgA; pfam03788 944547000910 LrgB-like family; Region: LrgB; pfam04172 944547000911 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 944547000912 dimerization interface [polypeptide binding]; other site 944547000913 putative DNA binding site [nucleotide binding]; other site 944547000914 putative Zn2+ binding site [ion binding]; other site 944547000915 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 944547000916 putative active site pocket [active] 944547000917 dimerization interface [polypeptide binding]; other site 944547000918 putative catalytic residue [active] 944547000919 arsenical pump membrane protein; Provisional; Region: PRK15445 944547000920 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 944547000921 transmembrane helices; other site 944547000922 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 944547000923 Low molecular weight phosphatase family; Region: LMWPc; cd00115 944547000924 active site 944547000925 Predicted permeases [General function prediction only]; Region: COG0701 944547000926 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 944547000927 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 944547000928 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 944547000929 Sulfate transporter family; Region: Sulfate_transp; pfam00916 944547000930 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 944547000931 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 944547000932 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 944547000933 DNA binding residues [nucleotide binding] 944547000934 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 944547000935 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 944547000936 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 944547000937 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 944547000938 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 944547000939 putative acyl-acceptor binding pocket; other site 944547000940 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 944547000941 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 944547000942 putative substrate translocation pore; other site 944547000943 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 944547000944 putative acyl-acceptor binding pocket; other site 944547000945 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 944547000946 acyl-activating enzyme (AAE) consensus motif; other site 944547000947 AMP binding site [chemical binding]; other site 944547000948 active site 944547000949 CoA binding site [chemical binding]; other site 944547000950 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 944547000951 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 944547000952 metal binding triad; other site 944547000953 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 944547000954 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 944547000955 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 944547000956 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 944547000957 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 944547000958 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547000959 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547000960 dimer interface [polypeptide binding]; other site 944547000961 phosphorylation site [posttranslational modification] 944547000962 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547000963 ATP binding site [chemical binding]; other site 944547000964 Mg2+ binding site [ion binding]; other site 944547000965 G-X-G motif; other site 944547000966 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 944547000967 Protein of unknown function (DUF815); Region: DUF815; pfam05673 944547000968 Walker A motif; other site 944547000969 ATP binding site [chemical binding]; other site 944547000970 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 944547000971 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 944547000972 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 944547000973 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 944547000974 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 944547000975 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 944547000976 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 944547000977 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 944547000978 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 944547000979 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 944547000980 Nitrogen regulatory protein P-II; Region: P-II; smart00938 944547000981 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 944547000982 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 944547000983 Nitrogen regulatory protein P-II; Region: P-II; smart00938 944547000984 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 944547000985 active site 944547000986 substrate binding pocket [chemical binding]; other site 944547000987 dimer interface [polypeptide binding]; other site 944547000988 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 944547000989 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 944547000990 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 944547000991 Flagellar P-ring protein; Region: FlgI; pfam02119 944547000992 Bacterial export proteins, family 3; Region: Bac_export_3; pfam01313 944547000993 Uncharacterized conserved protein [Function unknown]; Region: COG3334 944547000994 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 944547000995 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 944547000996 Flagellar L-ring protein; Region: FlgH; pfam02107 944547000997 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 944547000998 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 944547000999 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 944547001000 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 944547001001 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 944547001002 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 944547001003 Flagellar protein FliS; Region: FliS; cl00654 944547001004 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 944547001005 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 944547001006 Ligand Binding Site [chemical binding]; other site 944547001007 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 944547001008 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 944547001009 pantoate--beta-alanine ligase; Region: panC; TIGR00018 944547001010 Pantoate-beta-alanine ligase; Region: PanC; cd00560 944547001011 active site 944547001012 ATP-binding site [chemical binding]; other site 944547001013 pantoate-binding site; other site 944547001014 HXXH motif; other site 944547001015 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 944547001016 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 944547001017 dimer interface [polypeptide binding]; other site 944547001018 conserved gate region; other site 944547001019 putative PBP binding loops; other site 944547001020 ABC-ATPase subunit interface; other site 944547001021 CHAD domain; Region: CHAD; pfam05235 944547001022 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 944547001023 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 944547001024 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 944547001025 FAD binding site [chemical binding]; other site 944547001026 phosphoserine phosphatase SerB; Region: serB; TIGR00338 944547001027 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 944547001028 motif II; other site 944547001029 Class I aldolases; Region: Aldolase_Class_I; cl17187 944547001030 transaldolase; Provisional; Region: PRK03903 944547001031 catalytic residue [active] 944547001032 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 944547001033 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502 944547001034 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 944547001035 ArsC family; Region: ArsC; pfam03960 944547001036 catalytic residue [active] 944547001037 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 944547001038 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 944547001039 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 944547001040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3400 944547001041 TrkA-C domain; Region: TrkA_C; pfam02080 944547001042 hypothetical protein; Provisional; Region: PRK05839 944547001043 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 944547001044 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944547001045 homodimer interface [polypeptide binding]; other site 944547001046 catalytic residue [active] 944547001047 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 944547001048 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 944547001049 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 944547001050 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 944547001051 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 944547001052 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 944547001053 DNA protecting protein DprA; Region: dprA; TIGR00732 944547001054 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 944547001055 NodB motif; other site 944547001056 putative active site [active] 944547001057 putative catalytic site [active] 944547001058 Zn binding site [ion binding]; other site 944547001059 ketol-acid reductoisomerase; Provisional; Region: PRK05479 944547001060 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 944547001061 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 944547001062 RNB domain; Region: RNB; pfam00773 944547001063 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 944547001064 FliW protein; Region: FliW; cl00740 944547001065 DNA polymerase III subunit delta; Validated; Region: PRK08487 944547001066 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 944547001067 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 944547001068 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 944547001069 dimer interface [polypeptide binding]; other site 944547001070 ssDNA binding site [nucleotide binding]; other site 944547001071 tetramer (dimer of dimers) interface [polypeptide binding]; other site 944547001072 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 944547001073 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 944547001074 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 944547001075 active site 944547001076 HIGH motif; other site 944547001077 nucleotide binding site [chemical binding]; other site 944547001078 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 944547001079 KMSKS motif; other site 944547001080 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 944547001081 transcription elongation factor NusA; Provisional; Region: nusA; PRK12328 944547001082 NusA N-terminal domain; Region: NusA_N; pfam08529 944547001083 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 944547001084 RNA binding site [nucleotide binding]; other site 944547001085 homodimer interface [polypeptide binding]; other site 944547001086 NusA-like KH domain; Region: KH_5; pfam13184 944547001087 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 944547001088 G-X-X-G motif; other site 944547001089 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14339 944547001090 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 944547001091 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 944547001092 FeS/SAM binding site; other site 944547001093 TRAM domain; Region: TRAM; pfam01938 944547001094 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 944547001095 putative acyl-acceptor binding pocket; other site 944547001096 hypothetical protein; Provisional; Region: PRK08444 944547001097 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 944547001098 FeS/SAM binding site; other site 944547001099 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 944547001100 active site clefts [active] 944547001101 zinc binding site [ion binding]; other site 944547001102 dimer interface [polypeptide binding]; other site 944547001103 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 944547001104 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 944547001105 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 944547001106 catalytic residue [active] 944547001107 hypothetical protein; Reviewed; Region: PRK12497 944547001108 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 944547001109 thiS-thiF/thiG interaction site; other site 944547001110 Uncharacterized conserved protein [Function unknown]; Region: COG1565 944547001111 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 944547001112 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 944547001113 ligand binding site [chemical binding]; other site 944547001114 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 944547001115 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 944547001116 domain interfaces; other site 944547001117 active site 944547001118 Outer membrane efflux protein; Region: OEP; pfam02321 944547001119 Outer membrane efflux protein; Region: OEP; pfam02321 944547001120 acetylornithine aminotransferase; Provisional; Region: PRK02627 944547001121 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 944547001122 inhibitor-cofactor binding pocket; inhibition site 944547001123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944547001124 catalytic residue [active] 944547001125 Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934 944547001126 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 944547001127 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 944547001128 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 944547001129 chorismate binding enzyme; Region: Chorismate_bind; cl10555 944547001130 hypothetical protein; Provisional; Region: PRK07101 944547001131 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 944547001132 substrate-cofactor binding pocket; other site 944547001133 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944547001134 catalytic residue [active] 944547001135 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 944547001136 AzlC protein; Region: AzlC; cl00570 944547001137 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 944547001138 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 944547001139 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 944547001140 dimer interface [polypeptide binding]; other site 944547001141 active site 944547001142 CoA binding pocket [chemical binding]; other site 944547001143 putative phosphate acyltransferase; Provisional; Region: PRK05331 944547001144 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 944547001145 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 944547001146 active site 944547001147 multimer interface [polypeptide binding]; other site 944547001148 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 944547001149 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 944547001150 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 944547001151 dimer interface [polypeptide binding]; other site 944547001152 decamer (pentamer of dimers) interface [polypeptide binding]; other site 944547001153 catalytic triad [active] 944547001154 peroxidatic and resolving cysteines [active] 944547001155 transcription termination factor Rho; Provisional; Region: rho; PRK09376 944547001156 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 944547001157 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 944547001158 RNA binding site [nucleotide binding]; other site 944547001159 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 944547001160 multimer interface [polypeptide binding]; other site 944547001161 Walker A motif; other site 944547001162 ATP binding site [chemical binding]; other site 944547001163 Walker B motif; other site 944547001164 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 944547001165 putative active site [active] 944547001166 glutamate dehydrogenase; Provisional; Region: PRK09414 944547001167 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 944547001168 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 944547001169 NAD(P) binding site [chemical binding]; other site 944547001170 glutamate racemase; Provisional; Region: PRK00865 944547001171 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 944547001172 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 944547001173 Walker A motif; other site 944547001174 ATP binding site [chemical binding]; other site 944547001175 Walker B motif; other site 944547001176 arginine finger; other site 944547001177 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 944547001178 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 944547001179 catalytic residues [active] 944547001180 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 944547001181 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 944547001182 domain interfaces; other site 944547001183 active site 944547001184 Isochorismatase family; Region: Isochorismatase; pfam00857 944547001185 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 944547001186 catalytic triad [active] 944547001187 dimer interface [polypeptide binding]; other site 944547001188 conserved cis-peptide bond; other site 944547001189 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547001190 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547001191 metal binding site [ion binding]; metal-binding site 944547001192 active site 944547001193 I-site; other site 944547001194 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 944547001195 aconitate hydratase; Validated; Region: PRK09277 944547001196 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 944547001197 substrate binding site [chemical binding]; other site 944547001198 ligand binding site [chemical binding]; other site 944547001199 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 944547001200 substrate binding site [chemical binding]; other site 944547001201 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 944547001202 Citrate synthase; Region: Citrate_synt; pfam00285 944547001203 oxalacetate binding site [chemical binding]; other site 944547001204 citrylCoA binding site [chemical binding]; other site 944547001205 coenzyme A binding site [chemical binding]; other site 944547001206 catalytic triad [active] 944547001207 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 944547001208 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 944547001209 tetramer interface [polypeptide binding]; other site 944547001210 active site 944547001211 Mg2+/Mn2+ binding site [ion binding]; other site 944547001212 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 944547001213 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 944547001214 putative ligand binding site [chemical binding]; other site 944547001215 putative NAD binding site [chemical binding]; other site 944547001216 catalytic site [active] 944547001217 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 944547001218 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 944547001219 ligand binding site [chemical binding]; other site 944547001220 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 944547001221 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 944547001222 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 944547001223 Ca2+ binding site [ion binding]; other site 944547001224 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 944547001225 Ca2+ binding site [ion binding]; other site 944547001226 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 944547001227 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 944547001228 ATP binding site [chemical binding]; other site 944547001229 putative Mg++ binding site [ion binding]; other site 944547001230 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 944547001231 nucleotide binding region [chemical binding]; other site 944547001232 ATP-binding site [chemical binding]; other site 944547001233 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 944547001234 HRDC domain; Region: HRDC; pfam00570 944547001235 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 944547001236 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 944547001237 dimerization interface [polypeptide binding]; other site 944547001238 putative DNA binding site [nucleotide binding]; other site 944547001239 putative Zn2+ binding site [ion binding]; other site 944547001240 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 944547001241 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 944547001242 metal-binding site [ion binding] 944547001243 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 944547001244 Soluble P-type ATPase [General function prediction only]; Region: COG4087 944547001245 HPP family; Region: HPP; pfam04982 944547001246 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 944547001247 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 944547001248 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 944547001249 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 944547001250 GTP/Mg2+ binding site [chemical binding]; other site 944547001251 G5 box; other site 944547001252 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 944547001253 Dynamin family; Region: Dynamin_N; pfam00350 944547001254 G1 box; other site 944547001255 G1 box; other site 944547001256 GTP/Mg2+ binding site [chemical binding]; other site 944547001257 Switch I region; other site 944547001258 G2 box; other site 944547001259 G2 box; other site 944547001260 Switch I region; other site 944547001261 G3 box; other site 944547001262 Switch II region; other site 944547001263 G4 box; other site 944547001264 G5 box; other site 944547001265 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 944547001266 Dynamin family; Region: Dynamin_N; pfam00350 944547001267 G1 box; other site 944547001268 GTP/Mg2+ binding site [chemical binding]; other site 944547001269 G2 box; other site 944547001270 Switch I region; other site 944547001271 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 944547001272 G3 box; other site 944547001273 Switch II region; other site 944547001274 GTP/Mg2+ binding site [chemical binding]; other site 944547001275 G4 box; other site 944547001276 G5 box; other site 944547001277 fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552 944547001278 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 944547001279 fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626 944547001280 L-aspartate oxidase; Provisional; Region: PRK06175 944547001281 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 944547001282 fumarate reductase cytochrome b-556 subunit; Provisional; Region: PRK13553 944547001283 Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581 944547001284 Iron-sulfur protein interface; other site 944547001285 proximal heme binding site [chemical binding]; other site 944547001286 distal heme binding site [chemical binding]; other site 944547001287 dimer interface [polypeptide binding]; other site 944547001288 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 944547001289 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 944547001290 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 944547001291 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 944547001292 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 944547001293 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 944547001294 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 944547001295 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 944547001296 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 944547001297 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 944547001298 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 944547001299 4Fe-4S binding domain; Region: Fer4; pfam00037 944547001300 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 944547001301 NADH dehydrogenase; Region: NADHdh; cl00469 944547001302 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 944547001303 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 944547001304 catalytic loop [active] 944547001305 iron binding site [ion binding]; other site 944547001306 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 944547001307 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 944547001308 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 944547001309 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 944547001310 Citrate synthase; Region: Citrate_synt; pfam00285 944547001311 oxalacetate binding site [chemical binding]; other site 944547001312 citrylCoA binding site [chemical binding]; other site 944547001313 coenzyme A binding site [chemical binding]; other site 944547001314 catalytic triad [active] 944547001315 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 944547001316 SLBB domain; Region: SLBB; pfam10531 944547001317 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 944547001318 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 944547001319 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 944547001320 putative dimer interface [polypeptide binding]; other site 944547001321 [2Fe-2S] cluster binding site [ion binding]; other site 944547001322 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 944547001323 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 944547001324 NADH dehydrogenase subunit D; Validated; Region: PRK06075 944547001325 NADH dehydrogenase subunit B; Validated; Region: PRK06411 944547001326 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 944547001327 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 944547001328 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 944547001329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944547001330 homodimer interface [polypeptide binding]; other site 944547001331 catalytic residue [active] 944547001332 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 944547001333 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 944547001334 Uncharacterized conserved protein [Function unknown]; Region: COG2966 944547001335 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 944547001336 pantothenate kinase; Reviewed; Region: PRK13333 944547001337 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 944547001338 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 944547001339 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944547001340 Methyltransferase domain; Region: Methyltransf_23; pfam13489 944547001341 S-adenosylmethionine binding site [chemical binding]; other site 944547001342 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 944547001343 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 944547001344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547001345 active site 944547001346 phosphorylation site [posttranslational modification] 944547001347 intermolecular recognition site; other site 944547001348 dimerization interface [polypeptide binding]; other site 944547001349 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 944547001350 Zn2+ binding site [ion binding]; other site 944547001351 Mg2+ binding site [ion binding]; other site 944547001352 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547001353 dimer interface [polypeptide binding]; other site 944547001354 phosphorylation site [posttranslational modification] 944547001355 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547001356 ATP binding site [chemical binding]; other site 944547001357 Mg2+ binding site [ion binding]; other site 944547001358 G-X-G motif; other site 944547001359 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 944547001360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547001361 active site 944547001362 phosphorylation site [posttranslational modification] 944547001363 intermolecular recognition site; other site 944547001364 dimerization interface [polypeptide binding]; other site 944547001365 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547001366 PAS domain; Region: PAS_9; pfam13426 944547001367 putative active site [active] 944547001368 heme pocket [chemical binding]; other site 944547001369 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 944547001370 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 944547001371 FOG: CBS domain [General function prediction only]; Region: COG0517 944547001372 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 944547001373 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547001374 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547001375 metal binding site [ion binding]; metal-binding site 944547001376 active site 944547001377 I-site; other site 944547001378 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 944547001379 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 944547001380 active site 944547001381 HIGH motif; other site 944547001382 dimer interface [polypeptide binding]; other site 944547001383 KMSKS motif; other site 944547001384 muropeptide transporter; Validated; Region: ampG; cl17669 944547001385 Methyltransferase domain; Region: Methyltransf_31; pfam13847 944547001386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944547001387 S-adenosylmethionine binding site [chemical binding]; other site 944547001388 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 944547001389 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 944547001390 N-terminal plug; other site 944547001391 ligand-binding site [chemical binding]; other site 944547001392 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 944547001393 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 944547001394 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 944547001395 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 944547001396 putative metal binding site [ion binding]; other site 944547001397 putative homodimer interface [polypeptide binding]; other site 944547001398 putative homotetramer interface [polypeptide binding]; other site 944547001399 putative homodimer-homodimer interface [polypeptide binding]; other site 944547001400 putative allosteric switch controlling residues; other site 944547001401 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 944547001402 seryl-tRNA synthetase; Provisional; Region: PRK05431 944547001403 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 944547001404 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 944547001405 dimer interface [polypeptide binding]; other site 944547001406 active site 944547001407 motif 1; other site 944547001408 motif 2; other site 944547001409 motif 3; other site 944547001410 PhoD-like phosphatase; Region: PhoD; pfam09423 944547001411 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 944547001412 putative active site [active] 944547001413 putative metal binding site [ion binding]; other site 944547001414 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 944547001415 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547001416 PAS fold; Region: PAS_3; pfam08447 944547001417 putative active site [active] 944547001418 heme pocket [chemical binding]; other site 944547001419 NapD protein; Region: NapD; pfam03927 944547001420 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 944547001421 structural tetrad; other site 944547001422 FOG: WD40 repeat [General function prediction only]; Region: COG2319 944547001423 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 944547001424 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 944547001425 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 944547001426 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153 944547001427 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 944547001428 4Fe-4S binding domain; Region: Fer4_5; pfam12801 944547001429 4Fe-4S binding domain; Region: Fer4_5; pfam12801 944547001430 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 944547001431 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 944547001432 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 944547001433 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 944547001434 molybdopterin cofactor binding site; other site 944547001435 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 944547001436 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 944547001437 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 944547001438 molybdopterin cofactor binding site; other site 944547001439 PAS fold; Region: PAS_4; pfam08448 944547001440 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547001441 putative active site [active] 944547001442 heme pocket [chemical binding]; other site 944547001443 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547001444 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547001445 metal binding site [ion binding]; metal-binding site 944547001446 active site 944547001447 I-site; other site 944547001448 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 944547001449 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 944547001450 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 944547001451 active site 944547001452 SAM binding site [chemical binding]; other site 944547001453 homodimer interface [polypeptide binding]; other site 944547001454 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 944547001455 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 944547001456 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 944547001457 ligand binding site [chemical binding]; other site 944547001458 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 944547001459 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 944547001460 hypothetical protein; Provisional; Region: PRK07394 944547001461 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 944547001462 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 944547001463 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 944547001464 FeS/SAM binding site; other site 944547001465 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 944547001466 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 944547001467 16S/18S rRNA binding site [nucleotide binding]; other site 944547001468 S13e-L30e interaction site [polypeptide binding]; other site 944547001469 25S rRNA binding site [nucleotide binding]; other site 944547001470 Rrf2 family protein; Region: rrf2_super; TIGR00738 944547001471 Transcriptional regulator; Region: Rrf2; pfam02082 944547001472 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 944547001473 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 944547001474 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547001475 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547001476 dimer interface [polypeptide binding]; other site 944547001477 phosphorylation site [posttranslational modification] 944547001478 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547001479 ATP binding site [chemical binding]; other site 944547001480 Mg2+ binding site [ion binding]; other site 944547001481 G-X-G motif; other site 944547001482 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547001483 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547001484 active site 944547001485 phosphorylation site [posttranslational modification] 944547001486 intermolecular recognition site; other site 944547001487 dimerization interface [polypeptide binding]; other site 944547001488 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 944547001489 DNA binding site [nucleotide binding] 944547001490 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 944547001491 SurA N-terminal domain; Region: SurA_N_3; cl07813 944547001492 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 944547001493 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 944547001494 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 944547001495 active site 944547001496 intersubunit interface [polypeptide binding]; other site 944547001497 zinc binding site [ion binding]; other site 944547001498 Na+ binding site [ion binding]; other site 944547001499 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547001500 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547001501 active site 944547001502 phosphorylation site [posttranslational modification] 944547001503 intermolecular recognition site; other site 944547001504 dimerization interface [polypeptide binding]; other site 944547001505 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 944547001506 DNA binding site [nucleotide binding] 944547001507 Uncharacterized conserved protein [Function unknown]; Region: COG3287 944547001508 FIST N domain; Region: FIST; pfam08495 944547001509 FIST C domain; Region: FIST_C; pfam10442 944547001510 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547001511 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547001512 dimer interface [polypeptide binding]; other site 944547001513 phosphorylation site [posttranslational modification] 944547001514 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547001515 ATP binding site [chemical binding]; other site 944547001516 Mg2+ binding site [ion binding]; other site 944547001517 G-X-G motif; other site 944547001518 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 944547001519 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 944547001520 NAD(P) binding site [chemical binding]; other site 944547001521 catalytic residues [active] 944547001522 Protein of unknown function (DUF779); Region: DUF779; cl01432 944547001523 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 944547001524 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 944547001525 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 944547001526 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 944547001527 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 944547001528 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 944547001529 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 944547001530 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547001531 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547001532 dimer interface [polypeptide binding]; other site 944547001533 phosphorylation site [posttranslational modification] 944547001534 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547001535 ATP binding site [chemical binding]; other site 944547001536 Mg2+ binding site [ion binding]; other site 944547001537 G-X-G motif; other site 944547001538 FOG: CBS domain [General function prediction only]; Region: COG0517 944547001539 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 944547001540 FOG: CBS domain [General function prediction only]; Region: COG0517 944547001541 FOG: CBS domain [General function prediction only]; Region: COG0517 944547001542 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 944547001543 PAS domain; Region: PAS_9; pfam13426 944547001544 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547001545 putative active site [active] 944547001546 heme pocket [chemical binding]; other site 944547001547 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547001548 PAS domain; Region: PAS_9; pfam13426 944547001549 putative active site [active] 944547001550 heme pocket [chemical binding]; other site 944547001551 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547001552 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547001553 metal binding site [ion binding]; metal-binding site 944547001554 active site 944547001555 I-site; other site 944547001556 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 944547001557 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 944547001558 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 944547001559 ADP binding site [chemical binding]; other site 944547001560 magnesium binding site [ion binding]; other site 944547001561 putative shikimate binding site; other site 944547001562 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 944547001563 histidinol dehydrogenase; Region: hisD; TIGR00069 944547001564 NAD binding site [chemical binding]; other site 944547001565 dimerization interface [polypeptide binding]; other site 944547001566 product binding site; other site 944547001567 substrate binding site [chemical binding]; other site 944547001568 zinc binding site [ion binding]; other site 944547001569 catalytic residues [active] 944547001570 Domain of unknown function (DUF2018); Region: DUF2018; pfam09442 944547001571 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 944547001572 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 944547001573 substrate binding pocket [chemical binding]; other site 944547001574 chain length determination region; other site 944547001575 substrate-Mg2+ binding site; other site 944547001576 catalytic residues [active] 944547001577 aspartate-rich region 1; other site 944547001578 active site lid residues [active] 944547001579 aspartate-rich region 2; other site 944547001580 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 944547001581 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 944547001582 tRNA; other site 944547001583 putative tRNA binding site [nucleotide binding]; other site 944547001584 putative NADP binding site [chemical binding]; other site 944547001585 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 944547001586 prolyl-tRNA synthetase; Provisional; Region: PRK09194 944547001587 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 944547001588 motif 1; other site 944547001589 dimer interface [polypeptide binding]; other site 944547001590 active site 944547001591 motif 2; other site 944547001592 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 944547001593 putative deacylase active site [active] 944547001594 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 944547001595 active site 944547001596 motif 3; other site 944547001597 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 944547001598 anticodon binding site; other site 944547001599 Conserved TM helix; Region: TM_helix; pfam05552 944547001600 Mechanosensitive ion channel; Region: MS_channel; pfam00924 944547001601 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 944547001602 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 944547001603 active site 944547001604 NTP binding site [chemical binding]; other site 944547001605 metal binding triad [ion binding]; metal-binding site 944547001606 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 944547001607 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 944547001608 Zn2+ binding site [ion binding]; other site 944547001609 Mg2+ binding site [ion binding]; other site 944547001610 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 944547001611 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 944547001612 apolipoprotein N-acyltransferase; Reviewed; Region: PRK12291 944547001613 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 944547001614 active site 944547001615 catalytic triad [active] 944547001616 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 944547001617 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 944547001618 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 944547001619 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 944547001620 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 944547001621 Protein export membrane protein; Region: SecD_SecF; pfam02355 944547001622 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 944547001623 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 944547001624 HIGH motif; other site 944547001625 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 944547001626 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 944547001627 active site 944547001628 KMSKS motif; other site 944547001629 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 944547001630 tRNA binding surface [nucleotide binding]; other site 944547001631 Lipopolysaccharide-assembly; Region: LptE; pfam04390 944547001632 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 944547001633 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 944547001634 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 944547001635 DEAD-like helicases superfamily; Region: DEXDc; smart00487 944547001636 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 944547001637 ATP binding site [chemical binding]; other site 944547001638 putative Mg++ binding site [ion binding]; other site 944547001639 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 944547001640 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 944547001641 nucleotide binding region [chemical binding]; other site 944547001642 ATP-binding site [chemical binding]; other site 944547001643 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 944547001644 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 944547001645 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 944547001646 TrkA-N domain; Region: TrkA_N; pfam02254 944547001647 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 944547001648 active site residue [active] 944547001649 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 944547001650 putative acyl-acceptor binding pocket; other site 944547001651 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 944547001652 High-affinity nickel-transport protein; Region: NicO; cl00964 944547001653 Protein of unknown function (DUF1007); Region: DUF1007; cl01487 944547001654 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 944547001655 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 944547001656 SdiA-regulated; Region: SdiA-regulated; cd09971 944547001657 putative active site [active] 944547001658 Protein of unknown function (DUF445); Region: DUF445; pfam04286 944547001659 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 944547001660 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 944547001661 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 944547001662 ATP binding site [chemical binding]; other site 944547001663 putative Mg++ binding site [ion binding]; other site 944547001664 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 944547001665 nucleotide binding region [chemical binding]; other site 944547001666 ATP-binding site [chemical binding]; other site 944547001667 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 944547001668 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 944547001669 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 944547001670 Coenzyme A binding pocket [chemical binding]; other site 944547001671 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 944547001672 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 944547001673 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 944547001674 putative catalytic site [active] 944547001675 putative metal binding site [ion binding]; other site 944547001676 putative phosphate binding site [ion binding]; other site 944547001677 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 944547001678 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547001679 PAS domain; Region: PAS_9; pfam13426 944547001680 putative active site [active] 944547001681 heme pocket [chemical binding]; other site 944547001682 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547001683 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547001684 metal binding site [ion binding]; metal-binding site 944547001685 active site 944547001686 I-site; other site 944547001687 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 944547001688 dimer interface [polypeptide binding]; other site 944547001689 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 944547001690 Helix-turn-helix domain; Region: HTH_38; pfam13936 944547001691 Homeodomain-like domain; Region: HTH_32; pfam13565 944547001692 Integrase core domain; Region: rve; pfam00665 944547001693 Integrase core domain; Region: rve_3; cl15866 944547001694 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547001695 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547001696 active site 944547001697 phosphorylation site [posttranslational modification] 944547001698 intermolecular recognition site; other site 944547001699 dimerization interface [polypeptide binding]; other site 944547001700 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 944547001701 DNA binding site [nucleotide binding] 944547001702 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 944547001703 dimer interface [polypeptide binding]; other site 944547001704 phosphorylation site [posttranslational modification] 944547001705 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547001706 ATP binding site [chemical binding]; other site 944547001707 Mg2+ binding site [ion binding]; other site 944547001708 G-X-G motif; other site 944547001709 flavoprotein, HI0933 family; Region: TIGR00275 944547001710 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944547001711 dimer interface [polypeptide binding]; other site 944547001712 putative CheW interface [polypeptide binding]; other site 944547001713 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 944547001714 Response regulator receiver domain; Region: Response_reg; pfam00072 944547001715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547001716 active site 944547001717 phosphorylation site [posttranslational modification] 944547001718 intermolecular recognition site; other site 944547001719 dimerization interface [polypeptide binding]; other site 944547001720 PAS domain; Region: PAS_9; pfam13426 944547001721 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547001722 putative active site [active] 944547001723 heme pocket [chemical binding]; other site 944547001724 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547001725 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 944547001726 putative active site [active] 944547001727 heme pocket [chemical binding]; other site 944547001728 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547001729 putative active site [active] 944547001730 heme pocket [chemical binding]; other site 944547001731 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547001732 dimer interface [polypeptide binding]; other site 944547001733 phosphorylation site [posttranslational modification] 944547001734 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547001735 ATP binding site [chemical binding]; other site 944547001736 Mg2+ binding site [ion binding]; other site 944547001737 G-X-G motif; other site 944547001738 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 944547001739 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 944547001740 putative active site [active] 944547001741 metal binding site [ion binding]; metal-binding site 944547001742 homodimer binding site [polypeptide binding]; other site 944547001743 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 944547001744 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 944547001745 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944547001746 S-adenosylmethionine binding site [chemical binding]; other site 944547001747 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 944547001748 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 944547001749 generic binding surface II; other site 944547001750 generic binding surface I; other site 944547001751 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 944547001752 Response regulator receiver domain; Region: Response_reg; pfam00072 944547001753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547001754 active site 944547001755 phosphorylation site [posttranslational modification] 944547001756 intermolecular recognition site; other site 944547001757 dimerization interface [polypeptide binding]; other site 944547001758 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547001759 PAS domain; Region: PAS_9; pfam13426 944547001760 putative active site [active] 944547001761 heme pocket [chemical binding]; other site 944547001762 Methanol-cobalamin methyltransferase B subunit; Region: MtaB; pfam12176 944547001763 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 944547001764 active site 944547001765 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 944547001766 [2Fe-2S] cluster binding site [ion binding]; other site 944547001767 dimer interface [polypeptide binding]; other site 944547001768 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 944547001769 tetramerization interface [polypeptide binding]; other site 944547001770 active site 944547001771 hypothetical protein; Provisional; Region: PRK03762 944547001772 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 944547001773 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 944547001774 substrate binding pocket [chemical binding]; other site 944547001775 chain length determination region; other site 944547001776 substrate-Mg2+ binding site; other site 944547001777 catalytic residues [active] 944547001778 aspartate-rich region 1; other site 944547001779 active site lid residues [active] 944547001780 aspartate-rich region 2; other site 944547001781 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 944547001782 oligomerisation interface [polypeptide binding]; other site 944547001783 mobile loop; other site 944547001784 roof hairpin; other site 944547001785 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 944547001786 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 944547001787 ring oligomerisation interface [polypeptide binding]; other site 944547001788 ATP/Mg binding site [chemical binding]; other site 944547001789 stacking interactions; other site 944547001790 hinge regions; other site 944547001791 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 944547001792 Zn2+ binding site [ion binding]; other site 944547001793 Mg2+ binding site [ion binding]; other site 944547001794 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 944547001795 Zn2+ binding site [ion binding]; other site 944547001796 Mg2+ binding site [ion binding]; other site 944547001797 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 944547001798 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547001799 dimer interface [polypeptide binding]; other site 944547001800 phosphorylation site [posttranslational modification] 944547001801 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547001802 ATP binding site [chemical binding]; other site 944547001803 G-X-G motif; other site 944547001804 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547001805 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547001806 active site 944547001807 phosphorylation site [posttranslational modification] 944547001808 intermolecular recognition site; other site 944547001809 dimerization interface [polypeptide binding]; other site 944547001810 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 944547001811 DNA binding site [nucleotide binding] 944547001812 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 944547001813 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 944547001814 putative active site [active] 944547001815 putative metal binding site [ion binding]; other site 944547001816 YceI-like domain; Region: YceI; pfam04264 944547001817 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 944547001818 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 944547001819 Walker A/P-loop; other site 944547001820 ATP binding site [chemical binding]; other site 944547001821 Q-loop/lid; other site 944547001822 ABC transporter signature motif; other site 944547001823 Walker B; other site 944547001824 D-loop; other site 944547001825 H-loop/switch region; other site 944547001826 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 944547001827 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 944547001828 FtsX-like permease family; Region: FtsX; pfam02687 944547001829 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 944547001830 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 944547001831 active site 944547001832 dimerization interface [polypeptide binding]; other site 944547001833 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 944547001834 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 944547001835 glutaminase active site [active] 944547001836 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 944547001837 dimer interface [polypeptide binding]; other site 944547001838 active site 944547001839 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 944547001840 dimer interface [polypeptide binding]; other site 944547001841 active site 944547001842 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 944547001843 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 944547001844 S-adenosylmethionine synthetase; Validated; Region: PRK05250 944547001845 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 944547001846 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 944547001847 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 944547001848 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 944547001849 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 944547001850 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 944547001851 thiamine phosphate binding site [chemical binding]; other site 944547001852 active site 944547001853 pyrophosphate binding site [ion binding]; other site 944547001854 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 944547001855 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 944547001856 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 944547001857 FMN binding site [chemical binding]; other site 944547001858 active site 944547001859 catalytic residues [active] 944547001860 substrate binding site [chemical binding]; other site 944547001861 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 944547001862 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944547001863 S-adenosylmethionine binding site [chemical binding]; other site 944547001864 FtsH Extracellular; Region: FtsH_ext; pfam06480 944547001865 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 944547001866 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 944547001867 Walker A motif; other site 944547001868 ATP binding site [chemical binding]; other site 944547001869 Walker B motif; other site 944547001870 arginine finger; other site 944547001871 Peptidase family M41; Region: Peptidase_M41; pfam01434 944547001872 Response regulator receiver domain; Region: Response_reg; pfam00072 944547001873 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547001874 active site 944547001875 phosphorylation site [posttranslational modification] 944547001876 intermolecular recognition site; other site 944547001877 dimerization interface [polypeptide binding]; other site 944547001878 PAS domain; Region: PAS_9; pfam13426 944547001879 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547001880 PAS domain; Region: PAS_9; pfam13426 944547001881 putative active site [active] 944547001882 heme pocket [chemical binding]; other site 944547001883 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 944547001884 Zn2+ binding site [ion binding]; other site 944547001885 Mg2+ binding site [ion binding]; other site 944547001886 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 944547001887 dimerization interface [polypeptide binding]; other site 944547001888 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547001889 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547001890 dimer interface [polypeptide binding]; other site 944547001891 phosphorylation site [posttranslational modification] 944547001892 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547001893 ATP binding site [chemical binding]; other site 944547001894 Mg2+ binding site [ion binding]; other site 944547001895 G-X-G motif; other site 944547001896 2-isopropylmalate synthase; Validated; Region: PRK00915 944547001897 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 944547001898 active site 944547001899 catalytic residues [active] 944547001900 metal binding site [ion binding]; metal-binding site 944547001901 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 944547001902 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 944547001903 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 944547001904 Nitrogen regulatory protein P-II; Region: P-II; smart00938 944547001905 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 944547001906 catalytic residues [active] 944547001907 Haem-binding domain; Region: Haem_bd; pfam14376 944547001908 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 944547001909 MutS domain I; Region: MutS_I; pfam01624 944547001910 MutS domain III; Region: MutS_III; pfam05192 944547001911 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 944547001912 Walker A/P-loop; other site 944547001913 ATP binding site [chemical binding]; other site 944547001914 Q-loop/lid; other site 944547001915 ABC transporter signature motif; other site 944547001916 Walker B; other site 944547001917 D-loop; other site 944547001918 H-loop/switch region; other site 944547001919 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 944547001920 active site 944547001921 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 944547001922 Cytochrome c; Region: Cytochrom_C; cl11414 944547001923 quinohemoprotein amine dehydrogenase, alpha subunit; Region: QH_alpha; TIGR03908 944547001924 Cytochrome c; Region: Cytochrom_C; pfam00034 944547001925 Quinohemoprotein amine dehydrogenase A, alpha subunit, haem binding; Region: Dehyd-heme_bind; pfam09098 944547001926 Bacterial Ig-like domain (DUF1927); Region: DUF1927; pfam09099 944547001927 Domain of unknown function (DUF1928); Region: DUF1928; pfam09100 944547001928 quinohemoprotein amine dehydrogenase maturation protein; Region: quino_hemo_SAM; TIGR03906 944547001929 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 944547001930 FeS/SAM binding site; other site 944547001931 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 944547001932 Quinohemoprotein amine dehydrogenase, gamma subunit; Region: QH-AmDH_gamma; pfam08992 944547001933 quinohemoprotein amine dehydrogenase, beta subunit; Region: QH_beta; TIGR03907 944547001934 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 944547001935 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 944547001936 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 944547001937 Walker A/P-loop; other site 944547001938 ATP binding site [chemical binding]; other site 944547001939 Q-loop/lid; other site 944547001940 ABC transporter signature motif; other site 944547001941 Walker B; other site 944547001942 D-loop; other site 944547001943 H-loop/switch region; other site 944547001944 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 944547001945 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 944547001946 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 944547001947 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 944547001948 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547001949 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547001950 metal binding site [ion binding]; metal-binding site 944547001951 active site 944547001952 I-site; other site 944547001953 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 944547001954 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 944547001955 catalytic residues [active] 944547001956 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 944547001957 TIGR01777 family protein; Region: yfcH 944547001958 putative NAD(P) binding site [chemical binding]; other site 944547001959 putative active site [active] 944547001960 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 944547001961 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 944547001962 putative active site [active] 944547001963 oxyanion strand; other site 944547001964 catalytic triad [active] 944547001965 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 944547001966 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 944547001967 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 944547001968 active site 944547001969 GTP-binding protein LepA; Provisional; Region: PRK05433 944547001970 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 944547001971 G1 box; other site 944547001972 putative GEF interaction site [polypeptide binding]; other site 944547001973 GTP/Mg2+ binding site [chemical binding]; other site 944547001974 Switch I region; other site 944547001975 G2 box; other site 944547001976 G3 box; other site 944547001977 Switch II region; other site 944547001978 G4 box; other site 944547001979 G5 box; other site 944547001980 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 944547001981 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 944547001982 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 944547001983 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 944547001984 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 944547001985 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 944547001986 ligand binding site [chemical binding]; other site 944547001987 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 944547001988 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 944547001989 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 944547001990 ligand binding site [chemical binding]; other site 944547001991 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 944547001992 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 944547001993 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 944547001994 active site 944547001995 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 944547001996 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 944547001997 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 944547001998 Ligand Binding Site [chemical binding]; other site 944547001999 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 944547002000 catalytic center binding site [active] 944547002001 ATP binding site [chemical binding]; other site 944547002002 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 944547002003 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 944547002004 active site 944547002005 Dehydroquinase class II; Region: DHquinase_II; pfam01220 944547002006 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 944547002007 trimer interface [polypeptide binding]; other site 944547002008 active site 944547002009 dimer interface [polypeptide binding]; other site 944547002010 chlorohydrolase; Provisional; Region: PRK08418 944547002011 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 944547002012 active site 944547002013 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 944547002014 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 944547002015 tandem repeat interface [polypeptide binding]; other site 944547002016 oligomer interface [polypeptide binding]; other site 944547002017 active site residues [active] 944547002018 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 944547002019 propionate/acetate kinase; Provisional; Region: PRK12379 944547002020 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 944547002021 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 944547002022 propionate/acetate kinase; Provisional; Region: PRK12379 944547002023 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 944547002024 propionate/acetate kinase; Provisional; Region: PRK12379 944547002025 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 944547002026 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 944547002027 active site 944547002028 catalytic site [active] 944547002029 substrate binding site [chemical binding]; other site 944547002030 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 944547002031 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 944547002032 ligand binding site [chemical binding]; other site 944547002033 flexible hinge region; other site 944547002034 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 944547002035 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 944547002036 metal binding triad; other site 944547002037 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 944547002038 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 944547002039 Na binding site [ion binding]; other site 944547002040 Protein of unknown function, DUF485; Region: DUF485; pfam04341 944547002041 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 944547002042 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 944547002043 Na binding site [ion binding]; other site 944547002044 Protein of unknown function, DUF485; Region: DUF485; pfam04341 944547002045 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 944547002046 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 944547002047 active site 944547002048 catalytic site [active] 944547002049 substrate binding site [chemical binding]; other site 944547002050 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 944547002051 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 944547002052 ligand binding site [chemical binding]; other site 944547002053 flexible hinge region; other site 944547002054 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 944547002055 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 944547002056 metal binding triad; other site 944547002057 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 944547002058 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 944547002059 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 944547002060 Na binding site [ion binding]; other site 944547002061 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 944547002062 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547002063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547002064 active site 944547002065 phosphorylation site [posttranslational modification] 944547002066 intermolecular recognition site; other site 944547002067 dimerization interface [polypeptide binding]; other site 944547002068 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 944547002069 DNA binding site [nucleotide binding] 944547002070 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 944547002071 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547002072 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547002073 dimer interface [polypeptide binding]; other site 944547002074 phosphorylation site [posttranslational modification] 944547002075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547002076 ATP binding site [chemical binding]; other site 944547002077 Mg2+ binding site [ion binding]; other site 944547002078 G-X-G motif; other site 944547002079 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 944547002080 Predicted dehydrogenase [General function prediction only]; Region: COG0579 944547002081 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 944547002082 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 944547002083 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 944547002084 active site 944547002085 HIGH motif; other site 944547002086 nucleotide binding site [chemical binding]; other site 944547002087 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 944547002088 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 944547002089 active site 944547002090 KMSKS motif; other site 944547002091 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 944547002092 tRNA binding surface [nucleotide binding]; other site 944547002093 anticodon binding site; other site 944547002094 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 944547002095 NifU-like domain; Region: NifU; cl00484 944547002096 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 944547002097 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 944547002098 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 944547002099 PAS fold; Region: PAS_4; pfam08448 944547002100 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547002101 dimer interface [polypeptide binding]; other site 944547002102 phosphorylation site [posttranslational modification] 944547002103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547002104 ATP binding site [chemical binding]; other site 944547002105 G-X-G motif; other site 944547002106 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 944547002107 metal ion-dependent adhesion site (MIDAS); other site 944547002108 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 944547002109 Protein of unknown function DUF58; Region: DUF58; pfam01882 944547002110 MoxR-like ATPases [General function prediction only]; Region: COG0714 944547002111 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 944547002112 Walker A motif; other site 944547002113 ATP binding site [chemical binding]; other site 944547002114 Walker B motif; other site 944547002115 arginine finger; other site 944547002116 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 944547002117 rRNA interaction site [nucleotide binding]; other site 944547002118 S8 interaction site; other site 944547002119 putative laminin-1 binding site; other site 944547002120 elongation factor Ts; Provisional; Region: tsf; PRK09377 944547002121 UBA/TS-N domain; Region: UBA; pfam00627 944547002122 Elongation factor TS; Region: EF_TS; pfam00889 944547002123 Elongation factor TS; Region: EF_TS; pfam00889 944547002124 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 944547002125 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 944547002126 Walker A/P-loop; other site 944547002127 ATP binding site [chemical binding]; other site 944547002128 Q-loop/lid; other site 944547002129 ABC transporter signature motif; other site 944547002130 Walker B; other site 944547002131 D-loop; other site 944547002132 H-loop/switch region; other site 944547002133 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 944547002134 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 944547002135 catalytic site [active] 944547002136 G-X2-G-X-G-K; other site 944547002137 Response regulator receiver domain; Region: Response_reg; pfam00072 944547002138 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547002139 active site 944547002140 phosphorylation site [posttranslational modification] 944547002141 intermolecular recognition site; other site 944547002142 dimerization interface [polypeptide binding]; other site 944547002143 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547002144 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547002145 metal binding site [ion binding]; metal-binding site 944547002146 active site 944547002147 I-site; other site 944547002148 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 944547002149 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 944547002150 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 944547002151 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 944547002152 metal-binding site [ion binding] 944547002153 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 944547002154 Soluble P-type ATPase [General function prediction only]; Region: COG4087 944547002155 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 944547002156 Cytochrome c; Region: Cytochrom_C; cl11414 944547002157 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 944547002158 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 944547002159 Walker A/P-loop; other site 944547002160 ATP binding site [chemical binding]; other site 944547002161 Q-loop/lid; other site 944547002162 ABC transporter signature motif; other site 944547002163 Walker B; other site 944547002164 D-loop; other site 944547002165 H-loop/switch region; other site 944547002166 ferrochelatase; Reviewed; Region: hemH; PRK00035 944547002167 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 944547002168 C-terminal domain interface [polypeptide binding]; other site 944547002169 active site 944547002170 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 944547002171 active site 944547002172 N-terminal domain interface [polypeptide binding]; other site 944547002173 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 944547002174 AMMECR1; Region: AMMECR1; pfam01871 944547002175 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 944547002176 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 944547002177 FeS/SAM binding site; other site 944547002178 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 944547002179 putative ligand binding pocket/active site [active] 944547002180 putative metal binding site [ion binding]; other site 944547002181 Uncharacterized conserved protein [Function unknown]; Region: COG1434 944547002182 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 944547002183 putative active site [active] 944547002184 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 944547002185 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 944547002186 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 944547002187 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 944547002188 dimer interface [polypeptide binding]; other site 944547002189 putative PBP binding regions; other site 944547002190 ABC-ATPase subunit interface; other site 944547002191 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 944547002192 Helix-turn-helix domain; Region: HTH_18; pfam12833 944547002193 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 944547002194 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 944547002195 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 944547002196 MOSC domain; Region: MOSC; pfam03473 944547002197 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 944547002198 S1 domain; Region: S1_2; pfam13509 944547002199 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 944547002200 dimer interface [polypeptide binding]; other site 944547002201 catalytic triad [active] 944547002202 peroxidatic and resolving cysteines [active] 944547002203 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 944547002204 Sel1-like repeats; Region: SEL1; smart00671 944547002205 Sel1-like repeats; Region: SEL1; smart00671 944547002206 Sel1-like repeats; Region: SEL1; smart00671 944547002207 Sel1-like repeats; Region: SEL1; smart00671 944547002208 Sel1-like repeats; Region: SEL1; smart00671 944547002209 NnrS protein; Region: NnrS; cl01258 944547002210 TMAO/DMSO reductase; Reviewed; Region: PRK05363 944547002211 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 944547002212 Moco binding site; other site 944547002213 metal coordination site [ion binding]; other site 944547002214 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 944547002215 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 944547002216 Part of AAA domain; Region: AAA_19; pfam13245 944547002217 Family description; Region: UvrD_C_2; pfam13538 944547002218 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 944547002219 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 944547002220 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 944547002221 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 944547002222 Moco binding site; other site 944547002223 metal coordination site [ion binding]; other site 944547002224 Cytochrome c; Region: Cytochrom_C; pfam00034 944547002225 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 944547002226 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 944547002227 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 944547002228 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 944547002229 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 944547002230 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 944547002231 Cytochrome c [Energy production and conversion]; Region: COG3258 944547002232 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 944547002233 active site 944547002234 metal binding site [ion binding]; metal-binding site 944547002235 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 944547002236 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 944547002237 Cytochrome c; Region: Cytochrom_C; cl11414 944547002238 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 944547002239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 944547002240 DsrE/DsrF-like family; Region: DrsE; cl00672 944547002241 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 944547002242 Transcriptional regulator [Transcription]; Region: IclR; COG1414 944547002243 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 944547002244 Bacterial transcriptional regulator; Region: IclR; pfam01614 944547002245 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 944547002246 intracellular protease, PfpI family; Region: PfpI; TIGR01382 944547002247 conserved cys residue [active] 944547002248 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 944547002249 HD domain; Region: HD_5; pfam13487 944547002250 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 944547002251 active site residue [active] 944547002252 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 944547002253 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 944547002254 active site 944547002255 HIGH motif; other site 944547002256 nucleotide binding site [chemical binding]; other site 944547002257 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 944547002258 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 944547002259 active site 944547002260 KMSKS motif; other site 944547002261 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 944547002262 tRNA binding surface [nucleotide binding]; other site 944547002263 anticodon binding site; other site 944547002264 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 944547002265 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 944547002266 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 944547002267 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 944547002268 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 944547002269 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 944547002270 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 944547002271 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 944547002272 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547002273 metal binding site [ion binding]; metal-binding site 944547002274 active site 944547002275 I-site; other site 944547002276 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 944547002277 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 944547002278 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 944547002279 Major Facilitator Superfamily; Region: MFS_1; pfam07690 944547002280 putative substrate translocation pore; other site 944547002281 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 944547002282 active site 944547002283 dimerization interface [polypeptide binding]; other site 944547002284 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 944547002285 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 944547002286 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 944547002287 Histidine kinase; Region: HisKA_2; pfam07568 944547002288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547002289 ATP binding site [chemical binding]; other site 944547002290 Mg2+ binding site [ion binding]; other site 944547002291 G-X-G motif; other site 944547002292 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547002293 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547002294 active site 944547002295 phosphorylation site [posttranslational modification] 944547002296 intermolecular recognition site; other site 944547002297 dimerization interface [polypeptide binding]; other site 944547002298 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 944547002299 DNA binding site [nucleotide binding] 944547002300 haemagglutination activity domain; Region: Haemagg_act; smart00912 944547002301 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 944547002302 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 944547002303 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 944547002304 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 944547002305 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 944547002306 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 944547002307 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 944547002308 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 944547002309 Walker A motif; other site 944547002310 ATP binding site [chemical binding]; other site 944547002311 Walker B motif; other site 944547002312 arginine finger; other site 944547002313 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 944547002314 Rhomboid family; Region: Rhomboid; pfam01694 944547002315 Transcription elongation factor Spt4; Region: Spt4; cl12033 944547002316 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 944547002317 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 944547002318 Low molecular weight phosphatase family; Region: LMWPc; cd00115 944547002319 active site 944547002320 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547002321 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 944547002322 putative active site [active] 944547002323 heme pocket [chemical binding]; other site 944547002324 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547002325 putative active site [active] 944547002326 heme pocket [chemical binding]; other site 944547002327 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 944547002328 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944547002329 dimer interface [polypeptide binding]; other site 944547002330 putative CheW interface [polypeptide binding]; other site 944547002331 Uncharacterized conserved protein [Function unknown]; Region: COG0397 944547002332 hypothetical protein; Validated; Region: PRK00029 944547002333 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 944547002334 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 944547002335 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 944547002336 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 944547002337 HlyD family secretion protein; Region: HlyD_3; pfam13437 944547002338 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 944547002339 Protein export membrane protein; Region: SecD_SecF; cl14618 944547002340 Outer membrane efflux protein; Region: OEP; pfam02321 944547002341 Outer membrane efflux protein; Region: OEP; pfam02321 944547002342 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 944547002343 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 944547002344 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944547002345 dimer interface [polypeptide binding]; other site 944547002346 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 944547002347 putative CheW interface [polypeptide binding]; other site 944547002348 GAF domain; Region: GAF; pfam01590 944547002349 GAF domain; Region: GAF_2; pfam13185 944547002350 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547002351 PAS domain; Region: PAS_9; pfam13426 944547002352 putative active site [active] 944547002353 heme pocket [chemical binding]; other site 944547002354 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547002355 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547002356 metal binding site [ion binding]; metal-binding site 944547002357 active site 944547002358 I-site; other site 944547002359 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 944547002360 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 944547002361 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 944547002362 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 944547002363 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 944547002364 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 944547002365 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 944547002366 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 944547002367 HDOD domain; Region: HDOD; pfam08668 944547002368 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 944547002369 non-specific DNA binding site [nucleotide binding]; other site 944547002370 salt bridge; other site 944547002371 sequence-specific DNA binding site [nucleotide binding]; other site 944547002372 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 944547002373 Fe-S metabolism associated domain; Region: SufE; cl00951 944547002374 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 944547002375 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 944547002376 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 944547002377 catalytic residue [active] 944547002378 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 944547002379 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 944547002380 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 944547002381 FeS assembly ATPase SufC; Region: sufC; TIGR01978 944547002382 Walker A/P-loop; other site 944547002383 ATP binding site [chemical binding]; other site 944547002384 Q-loop/lid; other site 944547002385 ABC transporter signature motif; other site 944547002386 Walker B; other site 944547002387 D-loop; other site 944547002388 H-loop/switch region; other site 944547002389 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 944547002390 putative ABC transporter; Region: ycf24; CHL00085 944547002391 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547002392 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547002393 dimer interface [polypeptide binding]; other site 944547002394 phosphorylation site [posttranslational modification] 944547002395 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547002396 ATP binding site [chemical binding]; other site 944547002397 Mg2+ binding site [ion binding]; other site 944547002398 G-X-G motif; other site 944547002399 Cache domain; Region: Cache_1; pfam02743 944547002400 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547002401 PAS domain; Region: PAS_9; pfam13426 944547002402 putative active site [active] 944547002403 heme pocket [chemical binding]; other site 944547002404 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 944547002405 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 944547002406 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 944547002407 catalytic residue [active] 944547002408 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 944547002409 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 944547002410 trimerization site [polypeptide binding]; other site 944547002411 active site 944547002412 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 944547002413 NifU-like domain; Region: NifU; cl00484 944547002414 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 944547002415 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 944547002416 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 944547002417 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 944547002418 AAA domain; Region: AAA_11; pfam13086 944547002419 Part of AAA domain; Region: AAA_19; pfam13245 944547002420 AAA domain; Region: AAA_12; pfam13087 944547002421 FOG: CBS domain [General function prediction only]; Region: COG0517 944547002422 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 944547002423 hypothetical protein; Provisional; Region: PRK10621 944547002424 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 944547002425 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547002426 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547002427 metal binding site [ion binding]; metal-binding site 944547002428 active site 944547002429 I-site; other site 944547002430 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 944547002431 argininosuccinate lyase; Provisional; Region: PRK00855 944547002432 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 944547002433 active sites [active] 944547002434 tetramer interface [polypeptide binding]; other site 944547002435 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 944547002436 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 944547002437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547002438 active site 944547002439 phosphorylation site [posttranslational modification] 944547002440 intermolecular recognition site; other site 944547002441 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 944547002442 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 944547002443 putative ATP binding site [chemical binding]; other site 944547002444 putative substrate interface [chemical binding]; other site 944547002445 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 944547002446 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 944547002447 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 944547002448 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 944547002449 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 944547002450 putative active site [active] 944547002451 putative metal binding site [ion binding]; other site 944547002452 excinuclease ABC subunit B; Provisional; Region: PRK05298 944547002453 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 944547002454 ATP binding site [chemical binding]; other site 944547002455 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 944547002456 nucleotide binding region [chemical binding]; other site 944547002457 ATP-binding site [chemical binding]; other site 944547002458 Ultra-violet resistance protein B; Region: UvrB; pfam12344 944547002459 UvrB/uvrC motif; Region: UVR; pfam02151 944547002460 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 944547002461 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 944547002462 minor groove reading motif; other site 944547002463 helix-hairpin-helix signature motif; other site 944547002464 substrate binding pocket [chemical binding]; other site 944547002465 active site 944547002466 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 944547002467 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 944547002468 N-terminal plug; other site 944547002469 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 944547002470 ligand-binding site [chemical binding]; other site 944547002471 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 944547002472 HD domain; Region: HD_3; pfam13023 944547002473 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 944547002474 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 944547002475 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 944547002476 Coenzyme A binding pocket [chemical binding]; other site 944547002477 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 944547002478 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 944547002479 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 944547002480 Catalytic site [active] 944547002481 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 944547002482 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14191 944547002483 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 944547002484 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 944547002485 homodimer interface [polypeptide binding]; other site 944547002486 NADP binding site [chemical binding]; other site 944547002487 substrate binding site [chemical binding]; other site 944547002488 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 944547002489 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 944547002490 5S rRNA interface [nucleotide binding]; other site 944547002491 CTC domain interface [polypeptide binding]; other site 944547002492 L16 interface [polypeptide binding]; other site 944547002493 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 944547002494 putative active site [active] 944547002495 catalytic residue [active] 944547002496 Predicted permeases [General function prediction only]; Region: COG0795 944547002497 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 944547002498 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 944547002499 nudix motif; other site 944547002500 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 944547002501 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 944547002502 active site 944547002503 metal binding site [ion binding]; metal-binding site 944547002504 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 944547002505 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 944547002506 FMN binding site [chemical binding]; other site 944547002507 substrate binding site [chemical binding]; other site 944547002508 putative catalytic residue [active] 944547002509 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 944547002510 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 944547002511 active site 944547002512 HIGH motif; other site 944547002513 dimer interface [polypeptide binding]; other site 944547002514 KMSKS motif; other site 944547002515 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 944547002516 RNA binding surface [nucleotide binding]; other site 944547002517 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 944547002518 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 944547002519 Zn2+ binding site [ion binding]; other site 944547002520 Mg2+ binding site [ion binding]; other site 944547002521 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 944547002522 synthetase active site [active] 944547002523 NTP binding site [chemical binding]; other site 944547002524 metal binding site [ion binding]; metal-binding site 944547002525 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 944547002526 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 944547002527 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 944547002528 putative nucleotide binding site [chemical binding]; other site 944547002529 uridine monophosphate binding site [chemical binding]; other site 944547002530 homohexameric interface [polypeptide binding]; other site 944547002531 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 944547002532 AAA domain; Region: AAA_14; pfam13173 944547002533 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 944547002534 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK03946 944547002535 pyridoxine 5'-phosphate synthase; Provisional; Region: PRK05265 944547002536 active site 944547002537 hydrophilic channel; other site 944547002538 dimerization interface [polypeptide binding]; other site 944547002539 catalytic residues [active] 944547002540 active site lid [active] 944547002541 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 944547002542 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 944547002543 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 944547002544 Sporulation related domain; Region: SPOR; pfam05036 944547002545 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 944547002546 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 944547002547 dimer interface [polypeptide binding]; other site 944547002548 active site 944547002549 glycine-pyridoxal phosphate binding site [chemical binding]; other site 944547002550 folate binding site [chemical binding]; other site 944547002551 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 944547002552 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 944547002553 dimer interface [polypeptide binding]; other site 944547002554 putative anticodon binding site; other site 944547002555 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 944547002556 motif 1; other site 944547002557 active site 944547002558 motif 2; other site 944547002559 motif 3; other site 944547002560 Colicin V production protein; Region: Colicin_V; pfam02674 944547002561 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547002562 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547002563 dimer interface [polypeptide binding]; other site 944547002564 phosphorylation site [posttranslational modification] 944547002565 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547002566 ATP binding site [chemical binding]; other site 944547002567 Mg2+ binding site [ion binding]; other site 944547002568 G-X-G motif; other site 944547002569 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 944547002570 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 944547002571 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 944547002572 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 944547002573 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547002574 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547002575 metal binding site [ion binding]; metal-binding site 944547002576 active site 944547002577 I-site; other site 944547002578 replicative DNA helicase; Provisional; Region: PRK08506 944547002579 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 944547002580 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 944547002581 Walker A motif; other site 944547002582 ATP binding site [chemical binding]; other site 944547002583 Walker B motif; other site 944547002584 DNA binding loops [nucleotide binding] 944547002585 Chain length determinant protein; Region: Wzz; pfam02706 944547002586 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 944547002587 UDP-glucose 4-epimerase; Region: PLN02240 944547002588 NAD binding site [chemical binding]; other site 944547002589 homodimer interface [polypeptide binding]; other site 944547002590 active site 944547002591 substrate binding site [chemical binding]; other site 944547002592 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 944547002593 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 944547002594 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 944547002595 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 944547002596 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 944547002597 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 944547002598 NAD(P) binding site [chemical binding]; other site 944547002599 homodimer interface [polypeptide binding]; other site 944547002600 substrate binding site [chemical binding]; other site 944547002601 active site 944547002602 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 944547002603 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 944547002604 inhibitor-cofactor binding pocket; inhibition site 944547002605 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944547002606 catalytic residue [active] 944547002607 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 944547002608 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 944547002609 putative trimer interface [polypeptide binding]; other site 944547002610 putative CoA binding site [chemical binding]; other site 944547002611 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 944547002612 NeuB family; Region: NeuB; pfam03102 944547002613 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 944547002614 NeuB binding interface [polypeptide binding]; other site 944547002615 putative substrate binding site [chemical binding]; other site 944547002616 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 944547002617 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 944547002618 active site 944547002619 homodimer interface [polypeptide binding]; other site 944547002620 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 944547002621 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 944547002622 substrate binding site [chemical binding]; other site 944547002623 glutamase interaction surface [polypeptide binding]; other site 944547002624 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 944547002625 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 944547002626 putative active site [active] 944547002627 oxyanion strand; other site 944547002628 catalytic triad [active] 944547002629 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 944547002630 Ligand Binding Site [chemical binding]; other site 944547002631 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 944547002632 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 944547002633 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 944547002634 Substrate binding site; other site 944547002635 metal-binding site 944547002636 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 944547002637 ligand binding site; other site 944547002638 tetramer interface; other site 944547002639 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 944547002640 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 944547002641 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 944547002642 trimer interface [polypeptide binding]; other site 944547002643 active site 944547002644 substrate binding site [chemical binding]; other site 944547002645 CoA binding site [chemical binding]; other site 944547002646 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 944547002647 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 944547002648 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 944547002649 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 944547002650 active site 944547002651 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 944547002652 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 944547002653 Mg++ binding site [ion binding]; other site 944547002654 putative catalytic motif [active] 944547002655 putative substrate binding site [chemical binding]; other site 944547002656 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 944547002657 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 944547002658 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 944547002659 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 944547002660 NAD(P) binding site [chemical binding]; other site 944547002661 homodimer interface [polypeptide binding]; other site 944547002662 substrate binding site [chemical binding]; other site 944547002663 active site 944547002664 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 944547002665 DNA ligase; Provisional; Region: PRK09125 944547002666 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 944547002667 DNA binding site [nucleotide binding] 944547002668 active site 944547002669 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 944547002670 DNA binding site [nucleotide binding] 944547002671 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 944547002672 active site 944547002673 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 944547002674 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 944547002675 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944547002676 catalytic residue [active] 944547002677 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 944547002678 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 944547002679 multifunctional aminopeptidase A; Provisional; Region: PRK00913 944547002680 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 944547002681 interface (dimer of trimers) [polypeptide binding]; other site 944547002682 Substrate-binding/catalytic site; other site 944547002683 Zn-binding sites [ion binding]; other site 944547002684 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 944547002685 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 944547002686 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 944547002687 Outer membrane efflux protein; Region: OEP; pfam02321 944547002688 Outer membrane efflux protein; Region: OEP; pfam02321 944547002689 HlyD family secretion protein; Region: HlyD_2; pfam12700 944547002690 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 944547002691 HlyD family secretion protein; Region: HlyD_3; pfam13437 944547002692 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 944547002693 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 944547002694 Walker A/P-loop; other site 944547002695 ATP binding site [chemical binding]; other site 944547002696 Q-loop/lid; other site 944547002697 ABC transporter signature motif; other site 944547002698 Walker B; other site 944547002699 D-loop; other site 944547002700 H-loop/switch region; other site 944547002701 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 944547002702 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 944547002703 FtsX-like permease family; Region: FtsX; pfam02687 944547002704 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 944547002705 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 944547002706 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 944547002707 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 944547002708 Soluble P-type ATPase [General function prediction only]; Region: COG4087 944547002709 YtxH-like protein; Region: YtxH; pfam12732 944547002710 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB2; cd01048 944547002711 diiron binding motif [ion binding]; other site 944547002712 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 944547002713 metal binding site 2 [ion binding]; metal-binding site 944547002714 putative DNA binding helix; other site 944547002715 metal binding site 1 [ion binding]; metal-binding site 944547002716 dimer interface [polypeptide binding]; other site 944547002717 structural Zn2+ binding site [ion binding]; other site 944547002718 fumarate hydratase; Reviewed; Region: fumC; PRK00485 944547002719 Class II fumarases; Region: Fumarase_classII; cd01362 944547002720 active site 944547002721 tetramer interface [polypeptide binding]; other site 944547002722 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 944547002723 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547002724 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547002725 dimer interface [polypeptide binding]; other site 944547002726 phosphorylation site [posttranslational modification] 944547002727 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547002728 ATP binding site [chemical binding]; other site 944547002729 Mg2+ binding site [ion binding]; other site 944547002730 G-X-G motif; other site 944547002731 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547002732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547002733 active site 944547002734 phosphorylation site [posttranslational modification] 944547002735 intermolecular recognition site; other site 944547002736 dimerization interface [polypeptide binding]; other site 944547002737 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 944547002738 DNA binding site [nucleotide binding] 944547002739 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 944547002740 HlyD family secretion protein; Region: HlyD_3; pfam13437 944547002741 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 944547002742 Protein export membrane protein; Region: SecD_SecF; cl14618 944547002743 Protein export membrane protein; Region: SecD_SecF; cl14618 944547002744 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 944547002745 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 944547002746 N-terminal plug; other site 944547002747 ligand-binding site [chemical binding]; other site 944547002748 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 944547002749 Hemin uptake protein hemP; Region: hemP; pfam10636 944547002750 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 944547002751 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 944547002752 G1 box; other site 944547002753 GTP/Mg2+ binding site [chemical binding]; other site 944547002754 Switch I region; other site 944547002755 G2 box; other site 944547002756 G3 box; other site 944547002757 Switch II region; other site 944547002758 G4 box; other site 944547002759 G5 box; other site 944547002760 Nucleoside recognition; Region: Gate; pfam07670 944547002761 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 944547002762 Nucleoside recognition; Region: Gate; pfam07670 944547002763 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 944547002764 enterobactin receptor protein; Provisional; Region: PRK13483 944547002765 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 944547002766 N-terminal plug; other site 944547002767 ligand-binding site [chemical binding]; other site 944547002768 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 944547002769 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 944547002770 Histidine kinase; Region: HisKA_2; pfam07568 944547002771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 944547002772 ATP binding site [chemical binding]; other site 944547002773 Mg2+ binding site [ion binding]; other site 944547002774 G-X-G motif; other site 944547002775 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547002776 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547002777 active site 944547002778 phosphorylation site [posttranslational modification] 944547002779 intermolecular recognition site; other site 944547002780 dimerization interface [polypeptide binding]; other site 944547002781 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 944547002782 DNA binding site [nucleotide binding] 944547002783 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 944547002784 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 944547002785 N-terminal plug; other site 944547002786 ligand-binding site [chemical binding]; other site 944547002787 ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266 944547002788 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 944547002789 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 944547002790 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 944547002791 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 944547002792 Integrase core domain; Region: rve; pfam00665 944547002793 Integrase core domain; Region: rve_3; pfam13683 944547002794 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 944547002795 Transposase; Region: HTH_Tnp_1; pfam01527 944547002796 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 944547002797 Transposase; Region: HTH_Tnp_1; pfam01527 944547002798 Integrase core domain; Region: rve; pfam00665 944547002799 Integrase core domain; Region: rve_3; pfam13683 944547002800 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547002801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547002802 active site 944547002803 phosphorylation site [posttranslational modification] 944547002804 intermolecular recognition site; other site 944547002805 dimerization interface [polypeptide binding]; other site 944547002806 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 944547002807 DNA binding site [nucleotide binding] 944547002808 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 944547002809 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 944547002810 substrate binding pocket [chemical binding]; other site 944547002811 membrane-bound complex binding site; other site 944547002812 hinge residues; other site 944547002813 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547002814 haemagglutination activity domain; Region: Haemagg_act; pfam05860 944547002815 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 944547002816 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 944547002817 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 944547002818 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 944547002819 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 944547002820 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 944547002821 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 944547002822 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 944547002823 ATP binding site [chemical binding]; other site 944547002824 putative Mg++ binding site [ion binding]; other site 944547002825 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 944547002826 nucleotide binding region [chemical binding]; other site 944547002827 ATP-binding site [chemical binding]; other site 944547002828 AAA domain; Region: AAA_22; pfam13401 944547002829 Part of AAA domain; Region: AAA_19; pfam13245 944547002830 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 944547002831 Family description; Region: UvrD_C_2; pfam13538 944547002832 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 944547002833 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 944547002834 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 944547002835 DNA polymerase III PolC; Validated; Region: polC; PRK00448 944547002836 phosphodiesterase; Provisional; Region: PRK12704 944547002837 AAA domain; Region: AAA_11; pfam13086 944547002838 Part of AAA domain; Region: AAA_19; pfam13245 944547002839 AAA domain; Region: AAA_30; pfam13604 944547002840 AAA domain; Region: AAA_12; pfam13087 944547002841 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 944547002842 AAA domain; Region: AAA_13; pfam13166 944547002843 WYL domain; Region: WYL; cl14852 944547002844 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 944547002845 AAA domain; Region: AAA_23; pfam13476 944547002846 Walker A/P-loop; other site 944547002847 ATP binding site [chemical binding]; other site 944547002848 Q-loop/lid; other site 944547002849 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 944547002850 ABC transporter signature motif; other site 944547002851 Walker B; other site 944547002852 D-loop; other site 944547002853 H-loop/switch region; other site 944547002854 exonuclease subunit SbcD; Provisional; Region: PRK10966 944547002855 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 944547002856 active site 944547002857 metal binding site [ion binding]; metal-binding site 944547002858 DNA binding site [nucleotide binding] 944547002859 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 944547002860 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 944547002861 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 944547002862 catalytic residues [active] 944547002863 catalytic nucleophile [active] 944547002864 Presynaptic Site I dimer interface [polypeptide binding]; other site 944547002865 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 944547002866 Synaptic Flat tetramer interface [polypeptide binding]; other site 944547002867 Synaptic Site I dimer interface [polypeptide binding]; other site 944547002868 DNA binding site [nucleotide binding] 944547002869 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 944547002870 DNA-binding interface [nucleotide binding]; DNA binding site 944547002871 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 944547002872 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 944547002873 ATP binding site [chemical binding]; other site 944547002874 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 944547002875 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 944547002876 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 944547002877 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 944547002878 non-specific DNA binding site [nucleotide binding]; other site 944547002879 salt bridge; other site 944547002880 sequence-specific DNA binding site [nucleotide binding]; other site 944547002881 Domain of unknown function (DUF955); Region: DUF955; cl01076 944547002882 PIN domain; Region: PIN; pfam01850 944547002883 non-specific DNA binding site [nucleotide binding]; other site 944547002884 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 944547002885 salt bridge; other site 944547002886 sequence-specific DNA binding site [nucleotide binding]; other site 944547002887 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 944547002888 non-specific DNA binding site [nucleotide binding]; other site 944547002889 salt bridge; other site 944547002890 sequence-specific DNA binding site [nucleotide binding]; other site 944547002891 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 944547002892 AAA domain; Region: AAA_14; pfam13173 944547002893 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 944547002894 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 944547002895 active site 944547002896 catalytic residues [active] 944547002897 DNA binding site [nucleotide binding] 944547002898 Int/Topo IB signature motif; other site 944547002899 GTP-binding protein YchF; Reviewed; Region: PRK09601 944547002900 YchF GTPase; Region: YchF; cd01900 944547002901 G1 box; other site 944547002902 GTP/Mg2+ binding site [chemical binding]; other site 944547002903 Switch I region; other site 944547002904 G2 box; other site 944547002905 Switch II region; other site 944547002906 G3 box; other site 944547002907 G4 box; other site 944547002908 G5 box; other site 944547002909 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 944547002910 HDOD domain; Region: HDOD; pfam08668 944547002911 putative recombination protein RecO; Provisional; Region: PRK13908 944547002912 phosphoenolpyruvate synthase; Validated; Region: PRK06241 944547002913 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 944547002914 NosL; Region: NosL; cl01769 944547002915 NosL; Region: NosL; cl01769 944547002916 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 944547002917 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 944547002918 active site 944547002919 catalytic residues [active] 944547002920 DNA binding site [nucleotide binding] 944547002921 Int/Topo IB signature motif; other site 944547002922 AAA domain; Region: AAA_23; pfam13476 944547002923 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 944547002924 AAA domain; Region: AAA_30; pfam13604 944547002925 AAA domain; Region: AAA_12; pfam13087 944547002926 Catalytic domain of Protein Kinases; Region: PKc; cd00180 944547002927 active site 944547002928 ATP binding site [chemical binding]; other site 944547002929 substrate binding site [chemical binding]; other site 944547002930 activation loop (A-loop); other site 944547002931 Catalytic domain of Protein Kinases; Region: PKc; cd00180 944547002932 active site 944547002933 ATP binding site [chemical binding]; other site 944547002934 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 944547002935 substrate binding site [chemical binding]; other site 944547002936 activation loop (A-loop); other site 944547002937 Domain of unknown function (DUF1887); Region: DUF1887; pfam09002 944547002938 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 944547002939 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 944547002940 active site 944547002941 metal binding site [ion binding]; metal-binding site 944547002942 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 944547002943 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 944547002944 probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684 944547002945 Nuclease-related domain; Region: NERD; pfam08378 944547002946 Short C-terminal domain; Region: SHOCT; pfam09851 944547002947 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 944547002948 Predicted transcriptional regulator [Transcription]; Region: COG3355 944547002949 Helix-turn-helix domain; Region: HTH_17; cl17695 944547002950 Superoxide reductase-like (SORL) domain, class II; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_classII; cd03172 944547002951 non-heme iron binding site [ion binding]; other site 944547002952 tetramer interface [polypeptide binding]; other site 944547002953 thiamine monophosphate kinase; Provisional; Region: PRK05731 944547002954 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 944547002955 ATP binding site [chemical binding]; other site 944547002956 dimerization interface [polypeptide binding]; other site 944547002957 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 944547002958 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 944547002959 Permutation of conserved domain; other site 944547002960 active site 944547002961 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 944547002962 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 944547002963 N-terminal plug; other site 944547002964 ligand-binding site [chemical binding]; other site 944547002965 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 944547002966 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 944547002967 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944547002968 dimer interface [polypeptide binding]; other site 944547002969 putative CheW interface [polypeptide binding]; other site 944547002970 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 944547002971 RuvA N terminal domain; Region: RuvA_N; pfam01330 944547002972 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 944547002973 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 944547002974 ATP-grasp domain; Region: ATP-grasp_4; cl17255 944547002975 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 944547002976 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 944547002977 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 944547002978 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 944547002979 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 944547002980 nucleotide binding site/active site [active] 944547002981 HIT family signature motif; other site 944547002982 catalytic residue [active] 944547002983 Predicted transcriptional regulators [Transcription]; Region: COG1733 944547002984 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 944547002985 dimerization interface [polypeptide binding]; other site 944547002986 putative DNA binding site [nucleotide binding]; other site 944547002987 putative Zn2+ binding site [ion binding]; other site 944547002988 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 944547002989 dimer interface [polypeptide binding]; other site 944547002990 FMN binding site [chemical binding]; other site 944547002991 NADPH bind site [chemical binding]; other site 944547002992 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 944547002993 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 944547002994 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 944547002995 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 944547002996 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 944547002997 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 944547002998 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 944547002999 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 944547003000 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 944547003001 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 944547003002 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 944547003003 putative translocon binding site; other site 944547003004 protein-rRNA interface [nucleotide binding]; other site 944547003005 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 944547003006 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 944547003007 G-X-X-G motif; other site 944547003008 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 944547003009 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 944547003010 23S rRNA interface [nucleotide binding]; other site 944547003011 5S rRNA interface [nucleotide binding]; other site 944547003012 putative antibiotic binding site [chemical binding]; other site 944547003013 L25 interface [polypeptide binding]; other site 944547003014 L27 interface [polypeptide binding]; other site 944547003015 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 944547003016 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 944547003017 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 944547003018 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 944547003019 RNA binding site [nucleotide binding]; other site 944547003020 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 944547003021 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 944547003022 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 944547003023 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 944547003024 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 944547003025 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 944547003026 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 944547003027 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 944547003028 5S rRNA interface [nucleotide binding]; other site 944547003029 L27 interface [polypeptide binding]; other site 944547003030 23S rRNA interface [nucleotide binding]; other site 944547003031 L5 interface [polypeptide binding]; other site 944547003032 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 944547003033 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 944547003034 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 944547003035 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 944547003036 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 944547003037 SecY translocase; Region: SecY; pfam00344 944547003038 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 944547003039 active site 944547003040 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 944547003041 rRNA binding site [nucleotide binding]; other site 944547003042 predicted 30S ribosome binding site; other site 944547003043 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 944547003044 Fe-S cluster binding site [ion binding]; other site 944547003045 active site 944547003046 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 944547003047 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 944547003048 dimer interface [polypeptide binding]; other site 944547003049 anticodon binding site; other site 944547003050 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 944547003051 homodimer interface [polypeptide binding]; other site 944547003052 motif 1; other site 944547003053 active site 944547003054 motif 2; other site 944547003055 GAD domain; Region: GAD; pfam02938 944547003056 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 944547003057 active site 944547003058 motif 3; other site 944547003059 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 944547003060 intersubunit interface [polypeptide binding]; other site 944547003061 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 944547003062 uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904 944547003063 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 944547003064 adenylate kinase; Reviewed; Region: adk; PRK00279 944547003065 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 944547003066 AMP-binding site [chemical binding]; other site 944547003067 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 944547003068 adenylate kinase; Reviewed; Region: adk; PRK00279 944547003069 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 944547003070 AMP-binding site [chemical binding]; other site 944547003071 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 944547003072 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 944547003073 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 944547003074 MPT binding site; other site 944547003075 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 944547003076 Sel1-like repeats; Region: SEL1; smart00671 944547003077 Sel1-like repeats; Region: SEL1; smart00671 944547003078 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 944547003079 alanine racemase; Reviewed; Region: alr; PRK00053 944547003080 active site 944547003081 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 944547003082 dimer interface [polypeptide binding]; other site 944547003083 substrate binding site [chemical binding]; other site 944547003084 catalytic residues [active] 944547003085 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 944547003086 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 944547003087 GIY-YIG motif/motif A; other site 944547003088 active site 944547003089 catalytic site [active] 944547003090 putative DNA binding site [nucleotide binding]; other site 944547003091 metal binding site [ion binding]; metal-binding site 944547003092 UvrB/uvrC motif; Region: UVR; pfam02151 944547003093 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 944547003094 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 944547003095 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 944547003096 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547003097 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547003098 metal binding site [ion binding]; metal-binding site 944547003099 active site 944547003100 I-site; other site 944547003101 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 944547003102 active site 944547003103 substrate binding site [chemical binding]; other site 944547003104 ATP binding site [chemical binding]; other site 944547003105 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 944547003106 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 944547003107 catalytic residues [active] 944547003108 dimer interface [polypeptide binding]; other site 944547003109 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 944547003110 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944547003111 dimer interface [polypeptide binding]; other site 944547003112 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 944547003113 putative CheW interface [polypeptide binding]; other site 944547003114 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 944547003115 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944547003116 dimer interface [polypeptide binding]; other site 944547003117 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 944547003118 putative CheW interface [polypeptide binding]; other site 944547003119 Cache domain; Region: Cache_1; pfam02743 944547003120 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944547003121 dimer interface [polypeptide binding]; other site 944547003122 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 944547003123 putative CheW interface [polypeptide binding]; other site 944547003124 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 944547003125 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 944547003126 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 944547003127 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944547003128 dimer interface [polypeptide binding]; other site 944547003129 putative CheW interface [polypeptide binding]; other site 944547003130 SapC; Region: SapC; pfam07277 944547003131 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547003132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547003133 active site 944547003134 phosphorylation site [posttranslational modification] 944547003135 intermolecular recognition site; other site 944547003136 dimerization interface [polypeptide binding]; other site 944547003137 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 944547003138 Response regulator receiver domain; Region: Response_reg; pfam00072 944547003139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547003140 active site 944547003141 phosphorylation site [posttranslational modification] 944547003142 intermolecular recognition site; other site 944547003143 dimerization interface [polypeptide binding]; other site 944547003144 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547003145 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547003146 ATP binding site [chemical binding]; other site 944547003147 Mg2+ binding site [ion binding]; other site 944547003148 G-X-G motif; other site 944547003149 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547003150 HAMP domain; Region: HAMP; pfam00672 944547003151 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547003152 dimer interface [polypeptide binding]; other site 944547003153 phosphorylation site [posttranslational modification] 944547003154 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547003155 ATP binding site [chemical binding]; other site 944547003156 Mg2+ binding site [ion binding]; other site 944547003157 G-X-G motif; other site 944547003158 Response regulator receiver domain; Region: Response_reg; pfam00072 944547003159 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547003160 active site 944547003161 phosphorylation site [posttranslational modification] 944547003162 intermolecular recognition site; other site 944547003163 dimerization interface [polypeptide binding]; other site 944547003164 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 944547003165 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 944547003166 nudix motif; other site 944547003167 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 944547003168 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 944547003169 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 944547003170 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 944547003171 DctM-like transporters; Region: DctM; pfam06808 944547003172 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 944547003173 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 944547003174 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 944547003175 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; pfam04115 944547003176 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 944547003177 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 944547003178 putative ligand binding site [chemical binding]; other site 944547003179 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 944547003180 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 944547003181 TM-ABC transporter signature motif; other site 944547003182 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 944547003183 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 944547003184 TM-ABC transporter signature motif; other site 944547003185 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 944547003186 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 944547003187 Walker A/P-loop; other site 944547003188 ATP binding site [chemical binding]; other site 944547003189 Q-loop/lid; other site 944547003190 ABC transporter signature motif; other site 944547003191 Walker B; other site 944547003192 D-loop; other site 944547003193 H-loop/switch region; other site 944547003194 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 944547003195 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 944547003196 Walker A/P-loop; other site 944547003197 ATP binding site [chemical binding]; other site 944547003198 Q-loop/lid; other site 944547003199 ABC transporter signature motif; other site 944547003200 Walker B; other site 944547003201 D-loop; other site 944547003202 H-loop/switch region; other site 944547003203 UreD urease accessory protein; Region: UreD; cl00530 944547003204 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 944547003205 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 944547003206 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 944547003207 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 944547003208 TM-ABC transporter signature motif; other site 944547003209 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 944547003210 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 944547003211 TM-ABC transporter signature motif; other site 944547003212 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 944547003213 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 944547003214 Walker A/P-loop; other site 944547003215 ATP binding site [chemical binding]; other site 944547003216 Q-loop/lid; other site 944547003217 ABC transporter signature motif; other site 944547003218 Walker B; other site 944547003219 D-loop; other site 944547003220 H-loop/switch region; other site 944547003221 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 944547003222 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 944547003223 Walker A/P-loop; other site 944547003224 ATP binding site [chemical binding]; other site 944547003225 Q-loop/lid; other site 944547003226 ABC transporter signature motif; other site 944547003227 Walker B; other site 944547003228 D-loop; other site 944547003229 H-loop/switch region; other site 944547003230 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 944547003231 Transcriptional regulators [Transcription]; Region: GntR; COG1802 944547003232 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 944547003233 DNA-binding site [nucleotide binding]; DNA binding site 944547003234 FCD domain; Region: FCD; pfam07729 944547003235 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 944547003236 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 944547003237 active site 944547003238 catalytic site [active] 944547003239 tetramer interface [polypeptide binding]; other site 944547003240 allantoicase; Provisional; Region: PRK13257 944547003241 Allantoicase repeat; Region: Allantoicase; pfam03561 944547003242 Allantoicase repeat; Region: Allantoicase; pfam03561 944547003243 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; pfam04115 944547003244 malate synthase G; Provisional; Region: PRK02999 944547003245 active site 944547003246 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 944547003247 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 944547003248 alpha-gamma subunit interface [polypeptide binding]; other site 944547003249 beta-gamma subunit interface [polypeptide binding]; other site 944547003250 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 944547003251 gamma-beta subunit interface [polypeptide binding]; other site 944547003252 alpha-beta subunit interface [polypeptide binding]; other site 944547003253 urease subunit alpha; Reviewed; Region: ureC; PRK13207 944547003254 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 944547003255 subunit interactions [polypeptide binding]; other site 944547003256 active site 944547003257 flap region; other site 944547003258 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cl03727 944547003259 dimer interface [polypeptide binding]; other site 944547003260 catalytic residues [active] 944547003261 UreF; Region: UreF; pfam01730 944547003262 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 944547003263 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 944547003264 G1 box; other site 944547003265 GTP/Mg2+ binding site [chemical binding]; other site 944547003266 G2 box; other site 944547003267 Switch I region; other site 944547003268 G3 box; other site 944547003269 Switch II region; other site 944547003270 G4 box; other site 944547003271 G5 box; other site 944547003272 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 944547003273 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 944547003274 Bacterial transcriptional repressor; Region: TetR; pfam13972 944547003275 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 944547003276 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 944547003277 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 944547003278 HlyD family secretion protein; Region: HlyD_3; pfam13437 944547003279 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 944547003280 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 944547003281 MarR family; Region: MarR_2; pfam12802 944547003282 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 944547003283 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547003284 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547003285 metal binding site [ion binding]; metal-binding site 944547003286 active site 944547003287 I-site; other site 944547003288 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 944547003289 putative catalytic site [active] 944547003290 putative metal binding site [ion binding]; other site 944547003291 putative phosphate binding site [ion binding]; other site 944547003292 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 944547003293 putative substrate translocation pore; other site 944547003294 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 944547003295 Coenzyme A binding pocket [chemical binding]; other site 944547003296 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 944547003297 Predicted permeases [General function prediction only]; Region: COG0679 944547003298 Domain of unknown function (DUF386); Region: DUF386; cl01047 944547003299 glucose-6-phosphate isomerase; Provisional; Region: PRK03868 944547003300 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 944547003301 active site 944547003302 dimer interface [polypeptide binding]; other site 944547003303 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 944547003304 dimer interface [polypeptide binding]; other site 944547003305 active site 944547003306 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 944547003307 active site 944547003308 tetramer interface; other site 944547003309 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 944547003310 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 944547003311 active site 944547003312 substrate binding site [chemical binding]; other site 944547003313 metal binding site [ion binding]; metal-binding site 944547003314 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 944547003315 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 944547003316 active site 944547003317 Protein of unknown function (DUF423); Region: DUF423; pfam04241 944547003318 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 944547003319 NAD(P) binding site [chemical binding]; other site 944547003320 active site 944547003321 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 944547003322 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 944547003323 active site 944547003324 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 944547003325 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 944547003326 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 944547003327 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547003328 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547003329 active site 944547003330 phosphorylation site [posttranslational modification] 944547003331 intermolecular recognition site; other site 944547003332 dimerization interface [polypeptide binding]; other site 944547003333 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 944547003334 DNA binding site [nucleotide binding] 944547003335 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547003336 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547003337 dimer interface [polypeptide binding]; other site 944547003338 phosphorylation site [posttranslational modification] 944547003339 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547003340 ATP binding site [chemical binding]; other site 944547003341 Mg2+ binding site [ion binding]; other site 944547003342 G-X-G motif; other site 944547003343 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 944547003344 dimer interface [polypeptide binding]; other site 944547003345 ADP-ribose binding site [chemical binding]; other site 944547003346 active site 944547003347 nudix motif; other site 944547003348 metal binding site [ion binding]; metal-binding site 944547003349 Phospholipase A1; Region: PLA1; pfam02253 944547003350 dimerization interface [polypeptide binding]; other site 944547003351 substrate binding site [chemical binding]; other site 944547003352 active site 944547003353 calcium binding site [ion binding]; other site 944547003354 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 944547003355 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 944547003356 substrate binding site [chemical binding]; other site 944547003357 hexamer interface [polypeptide binding]; other site 944547003358 metal binding site [ion binding]; metal-binding site 944547003359 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 944547003360 active site 944547003361 DNA polymerase III subunit epsilon; Provisional; Region: PRK08517 944547003362 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 944547003363 active site 944547003364 catalytic site [active] 944547003365 substrate binding site [chemical binding]; other site 944547003366 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 944547003367 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 944547003368 Zn2+ binding site [ion binding]; other site 944547003369 Mg2+ binding site [ion binding]; other site 944547003370 2-oxoglutarate-acceptor oxidoreductase subunit OorC; Reviewed; Region: oorC; PRK08441 944547003371 2-oxoglutarate-acceptor oxidoreductase subunit OorB; Reviewed; Region: oorB; PRK09628 944547003372 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 944547003373 TPP-binding site [chemical binding]; other site 944547003374 2-oxoglutarate-acceptor oxidoreductase subunit OorA; Reviewed; Region: oorA; PRK09627 944547003375 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 944547003376 dimer interface [polypeptide binding]; other site 944547003377 PYR/PP interface [polypeptide binding]; other site 944547003378 TPP binding site [chemical binding]; other site 944547003379 substrate binding site [chemical binding]; other site 944547003380 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 944547003381 2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed; Region: oorD; PRK09626 944547003382 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 944547003383 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 944547003384 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 944547003385 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 944547003386 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 944547003387 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 944547003388 active site 944547003389 ribulose/triose binding site [chemical binding]; other site 944547003390 phosphate binding site [ion binding]; other site 944547003391 substrate (anthranilate) binding pocket [chemical binding]; other site 944547003392 product (indole) binding pocket [chemical binding]; other site 944547003393 Transcriptional regulator [Transcription]; Region: LysR; COG0583 944547003394 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 944547003395 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 944547003396 dimerization interface [polypeptide binding]; other site 944547003397 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 944547003398 active site 1 [active] 944547003399 dimer interface [polypeptide binding]; other site 944547003400 hexamer interface [polypeptide binding]; other site 944547003401 active site 2 [active] 944547003402 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547003403 PAS fold; Region: PAS_3; pfam08447 944547003404 putative active site [active] 944547003405 heme pocket [chemical binding]; other site 944547003406 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 944547003407 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944547003408 dimer interface [polypeptide binding]; other site 944547003409 putative CheW interface [polypeptide binding]; other site 944547003410 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 944547003411 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 944547003412 catalytic residue [active] 944547003413 RIP metalloprotease RseP; Region: TIGR00054 944547003414 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 944547003415 active site 944547003416 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 944547003417 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 944547003418 putative substrate binding region [chemical binding]; other site 944547003419 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 944547003420 7-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK08416 944547003421 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 944547003422 NAD(P) binding site [chemical binding]; other site 944547003423 active site 944547003424 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 944547003425 dihydrodipicolinate synthase; Region: dapA; TIGR00674 944547003426 dimer interface [polypeptide binding]; other site 944547003427 active site 944547003428 catalytic residue [active] 944547003429 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 944547003430 heme-binding site [chemical binding]; other site 944547003431 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 944547003432 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 944547003433 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 944547003434 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 944547003435 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 944547003436 quinone interaction residues [chemical binding]; other site 944547003437 active site 944547003438 catalytic residues [active] 944547003439 FMN binding site [chemical binding]; other site 944547003440 substrate binding site [chemical binding]; other site 944547003441 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 944547003442 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 944547003443 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 944547003444 Walker A/P-loop; other site 944547003445 ATP binding site [chemical binding]; other site 944547003446 Q-loop/lid; other site 944547003447 ABC transporter signature motif; other site 944547003448 Walker B; other site 944547003449 D-loop; other site 944547003450 H-loop/switch region; other site 944547003451 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 944547003452 MviN-like protein; Region: MVIN; pfam03023 944547003453 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 944547003454 putative catalytic site [active] 944547003455 putative metal binding site [ion binding]; other site 944547003456 putative phosphate binding site [ion binding]; other site 944547003457 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cl00018 944547003458 non-heme iron binding site [ion binding]; other site 944547003459 dimer interface [polypeptide binding]; other site 944547003460 Rubrerythrin [Energy production and conversion]; Region: COG1592 944547003461 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 944547003462 binuclear metal center [ion binding]; other site 944547003463 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 944547003464 iron binding site [ion binding]; other site 944547003465 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 944547003466 metal binding site 2 [ion binding]; metal-binding site 944547003467 putative DNA binding helix; other site 944547003468 metal binding site 1 [ion binding]; metal-binding site 944547003469 dimer interface [polypeptide binding]; other site 944547003470 structural Zn2+ binding site [ion binding]; other site 944547003471 metal-binding heat shock protein; Provisional; Region: PRK00016 944547003472 DNA repair protein RadA; Provisional; Region: PRK11823 944547003473 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 944547003474 Walker A motif/ATP binding site; other site 944547003475 ATP binding site [chemical binding]; other site 944547003476 Walker B motif; other site 944547003477 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 944547003478 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 944547003479 RNA/DNA hybrid binding site [nucleotide binding]; other site 944547003480 active site 944547003481 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; cl01409 944547003482 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 944547003483 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 944547003484 Autotransporter beta-domain; Region: Autotransporter; pfam03797 944547003485 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 944547003486 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 944547003487 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 944547003488 nucleophilic elbow; other site 944547003489 catalytic triad; other site 944547003490 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 944547003491 PAS domain S-box; Region: sensory_box; TIGR00229 944547003492 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547003493 putative active site [active] 944547003494 heme pocket [chemical binding]; other site 944547003495 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547003496 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547003497 metal binding site [ion binding]; metal-binding site 944547003498 active site 944547003499 I-site; other site 944547003500 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 944547003501 Gram-negative bacterial tonB protein; Region: TonB; cl10048 944547003502 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 944547003503 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 944547003504 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 944547003505 P loop; other site 944547003506 GTP binding site [chemical binding]; other site 944547003507 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 944547003508 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 944547003509 catalytic residues [active] 944547003510 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 944547003511 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 944547003512 phosphodiesterase; Provisional; Region: PRK12704 944547003513 Gamma subunit of transcription initiation factor IIA, N-terminal helical domain; Region: TFIIA_gamma_N; cl03508 944547003514 TFIIA subunit interface [polypeptide binding]; other site 944547003515 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 944547003516 Zn2+ binding site [ion binding]; other site 944547003517 Mg2+ binding site [ion binding]; other site 944547003518 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 944547003519 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 944547003520 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 944547003521 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 944547003522 dimer interface [polypeptide binding]; other site 944547003523 conserved gate region; other site 944547003524 putative PBP binding loops; other site 944547003525 ABC-ATPase subunit interface; other site 944547003526 short chain dehydrogenase; Provisional; Region: PRK05993 944547003527 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 944547003528 NADP binding site [chemical binding]; other site 944547003529 active site 944547003530 steroid binding site; other site 944547003531 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 944547003532 Cytochrome c [Energy production and conversion]; Region: COG3258 944547003533 Cytochrome c; Region: Cytochrom_C; pfam00034 944547003534 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547003535 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547003536 active site 944547003537 phosphorylation site [posttranslational modification] 944547003538 intermolecular recognition site; other site 944547003539 dimerization interface [polypeptide binding]; other site 944547003540 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 944547003541 DNA binding site [nucleotide binding] 944547003542 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547003543 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547003544 dimer interface [polypeptide binding]; other site 944547003545 phosphorylation site [posttranslational modification] 944547003546 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547003547 ATP binding site [chemical binding]; other site 944547003548 Mg2+ binding site [ion binding]; other site 944547003549 G-X-G motif; other site 944547003550 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547003551 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547003552 metal binding site [ion binding]; metal-binding site 944547003553 active site 944547003554 I-site; other site 944547003555 Yqey-like protein; Region: YqeY; pfam09424 944547003556 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 944547003557 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 944547003558 Walker A/P-loop; other site 944547003559 ATP binding site [chemical binding]; other site 944547003560 Q-loop/lid; other site 944547003561 ABC transporter signature motif; other site 944547003562 Walker B; other site 944547003563 D-loop; other site 944547003564 H-loop/switch region; other site 944547003565 ABC transporter; Region: ABC_tran_2; pfam12848 944547003566 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 944547003567 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 944547003568 Cation efflux family; Region: Cation_efflux; cl00316 944547003569 aspartate aminotransferase; Provisional; Region: PRK05764 944547003570 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 944547003571 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944547003572 homodimer interface [polypeptide binding]; other site 944547003573 catalytic residue [active] 944547003574 Protein of unknown function DUF45; Region: DUF45; pfam01863 944547003575 Protein of unknown function (DUF721); Region: DUF721; cl02324 944547003576 L-aspartate oxidase; Provisional; Region: PRK06175 944547003577 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 944547003578 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 944547003579 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 944547003580 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 944547003581 GMP synthase; Reviewed; Region: guaA; PRK00074 944547003582 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 944547003583 AMP/PPi binding site [chemical binding]; other site 944547003584 candidate oxyanion hole; other site 944547003585 catalytic triad [active] 944547003586 potential glutamine specificity residues [chemical binding]; other site 944547003587 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 944547003588 ATP Binding subdomain [chemical binding]; other site 944547003589 Ligand Binding sites [chemical binding]; other site 944547003590 Dimerization subdomain; other site 944547003591 hypothetical protein; Validated; Region: PRK00029 944547003592 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 944547003593 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 944547003594 Walker A/P-loop; other site 944547003595 ATP binding site [chemical binding]; other site 944547003596 Q-loop/lid; other site 944547003597 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 944547003598 ABC transporter signature motif; other site 944547003599 Walker B; other site 944547003600 D-loop; other site 944547003601 H-loop/switch region; other site 944547003602 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 944547003603 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 944547003604 Walker A/P-loop; other site 944547003605 ATP binding site [chemical binding]; other site 944547003606 Q-loop/lid; other site 944547003607 ABC transporter signature motif; other site 944547003608 Walker B; other site 944547003609 D-loop; other site 944547003610 H-loop/switch region; other site 944547003611 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 944547003612 MarR family; Region: MarR_2; pfam12802 944547003613 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 944547003614 homotrimer interaction site [polypeptide binding]; other site 944547003615 putative active site [active] 944547003616 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944547003617 S-adenosylmethionine binding site [chemical binding]; other site 944547003618 DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141 944547003619 catalytic site [active] 944547003620 putative active site [active] 944547003621 putative substrate binding site [chemical binding]; other site 944547003622 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 944547003623 EamA-like transporter family; Region: EamA; pfam00892 944547003624 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 944547003625 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 944547003626 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596 944547003627 active site 944547003628 Zn binding site [ion binding]; other site 944547003629 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 944547003630 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 944547003631 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 944547003632 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 944547003633 putative acyl-acceptor binding pocket; other site 944547003634 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 944547003635 amino acid transporter; Region: 2A0306; TIGR00909 944547003636 Hemerythrin; Region: Hemerythrin; cd12107 944547003637 Fe binding site [ion binding]; other site 944547003638 Acyltransferase family; Region: Acyl_transf_3; pfam01757 944547003639 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 944547003640 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 944547003641 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 944547003642 active site 944547003643 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 944547003644 Walker A motif; other site 944547003645 ATP binding site [chemical binding]; other site 944547003646 Walker B motif; other site 944547003647 arginine finger; other site 944547003648 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 944547003649 transcription elongation factor GreA; Region: greA; TIGR01462 944547003650 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 944547003651 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 944547003652 S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672 944547003653 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944547003654 S-adenosylmethionine binding site [chemical binding]; other site 944547003655 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 944547003656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 944547003657 putative substrate translocation pore; other site 944547003658 Transcriptional regulators [Transcription]; Region: FadR; COG2186 944547003659 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 944547003660 DNA-binding site [nucleotide binding]; DNA binding site 944547003661 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 944547003662 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 944547003663 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 944547003664 putative substrate translocation pore; other site 944547003665 Family of unknown function (DUF490); Region: DUF490; pfam04357 944547003666 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 944547003667 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 944547003668 Surface antigen; Region: Bac_surface_Ag; pfam01103 944547003669 short chain dehydrogenase; Provisional; Region: PRK06924 944547003670 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 944547003671 NAD(P) binding site [chemical binding]; other site 944547003672 active site 944547003673 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 944547003674 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 944547003675 catalytic triad [active] 944547003676 ORF6N domain; Region: ORF6N; pfam10543 944547003677 HD domain; Region: HD; pfam01966 944547003678 Zn2+ binding site [ion binding]; other site 944547003679 Mg2+ binding site [ion binding]; other site 944547003680 Putative gypsy type transposon; Region: Transposase_28; pfam04195 944547003681 Domain of unknown function DUF21; Region: DUF21; pfam01595 944547003682 FOG: CBS domain [General function prediction only]; Region: COG0517 944547003683 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 944547003684 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 944547003685 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 944547003686 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 944547003687 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 944547003688 DTW domain; Region: DTW; cl01221 944547003689 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 944547003690 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 944547003691 Domain of unknown function DUF87; Region: DUF87; pfam01935 944547003692 Zonular occludens toxin (Zot); Region: Zot; cl17485 944547003693 Domain of unknown function DUF21; Region: DUF21; pfam01595 944547003694 FOG: CBS domain [General function prediction only]; Region: COG0517 944547003695 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 944547003696 Domain of unknown function (DUF309); Region: DUF309; cl00667 944547003697 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 944547003698 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 944547003699 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 944547003700 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 944547003701 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 944547003702 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 944547003703 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 944547003704 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 944547003705 HPP family; Region: HPP; pfam04982 944547003706 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 944547003707 ATP-grasp domain; Region: ATP-grasp_4; cl17255 944547003708 helicase 45; Provisional; Region: PTZ00424 944547003709 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 944547003710 ATP binding site [chemical binding]; other site 944547003711 Mg++ binding site [ion binding]; other site 944547003712 motif III; other site 944547003713 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 944547003714 nucleotide binding region [chemical binding]; other site 944547003715 ATP-binding site [chemical binding]; other site 944547003716 PAS domain; Region: PAS_8; pfam13188 944547003717 PAS domain; Region: PAS_9; pfam13426 944547003718 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547003719 putative active site [active] 944547003720 heme pocket [chemical binding]; other site 944547003721 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547003722 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547003723 metal binding site [ion binding]; metal-binding site 944547003724 active site 944547003725 I-site; other site 944547003726 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 944547003727 PAS fold; Region: PAS; pfam00989 944547003728 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547003729 putative active site [active] 944547003730 heme pocket [chemical binding]; other site 944547003731 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 944547003732 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944547003733 dimer interface [polypeptide binding]; other site 944547003734 putative CheW interface [polypeptide binding]; other site 944547003735 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 944547003736 non-specific DNA binding site [nucleotide binding]; other site 944547003737 salt bridge; other site 944547003738 sequence-specific DNA binding site [nucleotide binding]; other site 944547003739 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 944547003740 serine O-acetyltransferase; Region: cysE; TIGR01172 944547003741 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 944547003742 trimer interface [polypeptide binding]; other site 944547003743 active site 944547003744 substrate binding site [chemical binding]; other site 944547003745 CoA binding site [chemical binding]; other site 944547003746 arginine decarboxylase; Provisional; Region: PRK05354 944547003747 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 944547003748 dimer interface [polypeptide binding]; other site 944547003749 active site 944547003750 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 944547003751 catalytic residues [active] 944547003752 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 944547003753 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 944547003754 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 944547003755 dimer interface [polypeptide binding]; other site 944547003756 motif 1; other site 944547003757 active site 944547003758 motif 2; other site 944547003759 motif 3; other site 944547003760 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 944547003761 anticodon binding site; other site 944547003762 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 944547003763 thymidylate kinase; Validated; Region: tmk; PRK00698 944547003764 TMP-binding site; other site 944547003765 ATP-binding site [chemical binding]; other site 944547003766 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 944547003767 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 944547003768 active site 944547003769 (T/H)XGH motif; other site 944547003770 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 944547003771 Flavoprotein; Region: Flavoprotein; pfam02441 944547003772 multiple promoter invertase; Provisional; Region: mpi; PRK13413 944547003773 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 944547003774 catalytic residues [active] 944547003775 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 944547003776 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 944547003777 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 944547003778 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 944547003779 active site 944547003780 HslU subunit interaction site [polypeptide binding]; other site 944547003781 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 944547003782 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 944547003783 Walker A motif; other site 944547003784 ATP binding site [chemical binding]; other site 944547003785 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 944547003786 Walker B motif; other site 944547003787 arginine finger; other site 944547003788 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 944547003789 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 944547003790 active site 944547003791 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 944547003792 N-acetyl-D-glucosamine binding site [chemical binding]; other site 944547003793 catalytic residue [active] 944547003794 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 944547003795 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 944547003796 Sporulation related domain; Region: SPOR; pfam05036 944547003797 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 944547003798 putative active site pocket [active] 944547003799 4-fold oligomerization interface [polypeptide binding]; other site 944547003800 metal binding residues [ion binding]; metal-binding site 944547003801 3-fold/trimer interface [polypeptide binding]; other site 944547003802 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 944547003803 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 944547003804 active site 944547003805 motif I; other site 944547003806 motif II; other site 944547003807 OstA-like protein; Region: OstA; pfam03968 944547003808 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 944547003809 G1 box; other site 944547003810 GTP/Mg2+ binding site [chemical binding]; other site 944547003811 Switch I region; other site 944547003812 G2 box; other site 944547003813 G3 box; other site 944547003814 Switch II region; other site 944547003815 G4 box; other site 944547003816 G5 box; other site 944547003817 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 944547003818 Coenzyme A binding pocket [chemical binding]; other site 944547003819 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 944547003820 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 944547003821 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 944547003822 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 944547003823 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 944547003824 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 944547003825 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 944547003826 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 944547003827 DNA-binding site [nucleotide binding]; DNA binding site 944547003828 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 944547003829 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944547003830 homodimer interface [polypeptide binding]; other site 944547003831 catalytic residue [active] 944547003832 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 944547003833 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 944547003834 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 944547003835 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 944547003836 HlyD family secretion protein; Region: HlyD_3; pfam13437 944547003837 Outer membrane efflux protein; Region: OEP; pfam02321 944547003838 Outer membrane efflux protein; Region: OEP; pfam02321 944547003839 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 944547003840 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 944547003841 active site residue [active] 944547003842 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 944547003843 active site residue [active] 944547003844 HAMP domain; Region: HAMP; pfam00672 944547003845 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547003846 PAS domain; Region: PAS_9; pfam13426 944547003847 putative active site [active] 944547003848 heme pocket [chemical binding]; other site 944547003849 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547003850 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547003851 ATP binding site [chemical binding]; other site 944547003852 Mg2+ binding site [ion binding]; other site 944547003853 G-X-G motif; other site 944547003854 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 944547003855 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 944547003856 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 944547003857 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 944547003858 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 944547003859 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 944547003860 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 944547003861 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 944547003862 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 944547003863 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 944547003864 ArsC family; Region: ArsC; pfam03960 944547003865 catalytic residues [active] 944547003866 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 944547003867 AAA domain; Region: AAA_30; pfam13604 944547003868 Family description; Region: UvrD_C_2; pfam13538 944547003869 SurA N-terminal domain; Region: SurA_N_3; cl07813 944547003870 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 944547003871 cell division protein FtsA; Region: ftsA; TIGR01174 944547003872 Cell division protein FtsA; Region: FtsA; smart00842 944547003873 Cell division protein FtsA; Region: FtsA; pfam14450 944547003874 cell division protein FtsZ; Validated; Region: PRK09330 944547003875 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 944547003876 nucleotide binding site [chemical binding]; other site 944547003877 SulA interaction site; other site 944547003878 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 944547003879 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 944547003880 Putative phosphatase (DUF442); Region: DUF442; cl17385 944547003881 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 944547003882 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 944547003883 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 944547003884 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 944547003885 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 944547003886 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 944547003887 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 944547003888 Putative catalytic NodB homology domain of uncharacterized BH0857 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH0857_like; cd10955 944547003889 NodB motif; other site 944547003890 putative active site [active] 944547003891 putative catalytic site [active] 944547003892 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 944547003893 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 944547003894 ATP binding site [chemical binding]; other site 944547003895 substrate interface [chemical binding]; other site 944547003896 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 944547003897 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 944547003898 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 944547003899 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 944547003900 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 944547003901 ATP-grasp domain; Region: ATP-grasp_4; cl17255 944547003902 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 944547003903 IMP binding site; other site 944547003904 dimer interface [polypeptide binding]; other site 944547003905 partial ornithine binding site; other site 944547003906 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 944547003907 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 944547003908 TraE protein; Region: TraE; cl05060 944547003909 TraK protein; Region: TraK; pfam06586 944547003910 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 944547003911 type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746 944547003912 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 944547003913 conjugative transfer signal peptidase TraF; Region: TraF_Ti; TIGR02771 944547003914 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 944547003915 Conjugative relaxosome accessory transposon protein; Region: TraH; cl05580 944547003916 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 944547003917 A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603 944547003918 ligand binding surface [chemical binding]; other site 944547003919 conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355 944547003920 RES domain; Region: RES; pfam08808 944547003921 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; cl09883 944547003922 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 944547003923 TraU protein; Region: TraU; pfam06834 944547003924 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 944547003925 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 944547003926 F plasmid transfer operon protein; Region: TraF; pfam13728 944547003927 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 944547003928 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 944547003929 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 944547003930 Walker A motif; other site 944547003931 ATP binding site [chemical binding]; other site 944547003932 Walker B motif; other site 944547003933 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 944547003934 nickel responsive regulator; Provisional; Region: PRK02967 944547003935 Helix-turn-helix domain; Region: HTH_17; cl17695 944547003936 DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864 944547003937 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 944547003938 active site 944547003939 substrate binding site [chemical binding]; other site 944547003940 Mg2+ binding site [ion binding]; other site 944547003941 nicotinate-nucleotide diphosphorylase (carboxylating); Region: PLN02716 944547003942 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 944547003943 non-specific DNA binding site [nucleotide binding]; other site 944547003944 salt bridge; other site 944547003945 sequence-specific DNA binding site [nucleotide binding]; other site 944547003946 Protein of unknown function (DUF3732); Region: DUF3732; pfam12532 944547003947 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509 944547003948 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 944547003949 His-Xaa-Ser system protein HsxD; Region: chp_LLNDYxLRE; TIGR03976 944547003950 His-Xaa-Ser system radical SAM maturase HxsB; Region: rSAM_paired_1; TIGR03978 944547003951 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 944547003952 FeS/SAM binding site; other site 944547003953 His-Xaa-Ser system radical SAM maturase HxsC; Region: rSAM_pair_HxsC; TIGR03977 944547003954 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 944547003955 FeS/SAM binding site; other site 944547003956 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 944547003957 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 944547003958 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 944547003959 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 944547003960 active site 944547003961 catalytic residues [active] 944547003962 DNA binding site [nucleotide binding] 944547003963 Int/Topo IB signature motif; other site 944547003964 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 944547003965 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 944547003966 flagellar motor protein MotB; Reviewed; Region: motB; PRK08457 944547003967 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 944547003968 ligand binding site [chemical binding]; other site 944547003969 hypothetical protein; Provisional; Region: PRK14013 944547003970 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 944547003971 Citrate transporter; Region: CitMHS; pfam03600 944547003972 Ion transport protein; Region: Ion_trans; pfam00520 944547003973 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 944547003974 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 944547003975 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 944547003976 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 944547003977 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 944547003978 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 944547003979 Walker A/P-loop; other site 944547003980 ATP binding site [chemical binding]; other site 944547003981 Q-loop/lid; other site 944547003982 ABC transporter signature motif; other site 944547003983 Walker B; other site 944547003984 D-loop; other site 944547003985 H-loop/switch region; other site 944547003986 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 944547003987 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 944547003988 Walker A/P-loop; other site 944547003989 ATP binding site [chemical binding]; other site 944547003990 Q-loop/lid; other site 944547003991 ABC transporter signature motif; other site 944547003992 Walker B; other site 944547003993 D-loop; other site 944547003994 H-loop/switch region; other site 944547003995 HlyD family secretion protein; Region: HlyD; pfam00529 944547003996 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 944547003997 HlyD family secretion protein; Region: HlyD_3; pfam13437 944547003998 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 944547003999 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 944547004000 DNA binding residues [nucleotide binding] 944547004001 putative dimer interface [polypeptide binding]; other site 944547004002 chaperone protein DnaJ; Provisional; Region: PRK14299 944547004003 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 944547004004 HSP70 interaction site [polypeptide binding]; other site 944547004005 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 944547004006 substrate binding site [polypeptide binding]; other site 944547004007 dimer interface [polypeptide binding]; other site 944547004008 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 944547004009 PAS domain; Region: PAS_9; pfam13426 944547004010 putative active site [active] 944547004011 heme pocket [chemical binding]; other site 944547004012 PAS domain; Region: PAS_8; pfam13188 944547004013 PAS domain; Region: PAS_9; pfam13426 944547004014 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547004015 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 944547004016 dimer interface [polypeptide binding]; other site 944547004017 phosphorylation site [posttranslational modification] 944547004018 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547004019 ATP binding site [chemical binding]; other site 944547004020 Mg2+ binding site [ion binding]; other site 944547004021 G-X-G motif; other site 944547004022 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 944547004023 Response regulator receiver domain; Region: Response_reg; pfam00072 944547004024 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547004025 active site 944547004026 phosphorylation site [posttranslational modification] 944547004027 intermolecular recognition site; other site 944547004028 dimerization interface [polypeptide binding]; other site 944547004029 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 944547004030 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 944547004031 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 944547004032 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 944547004033 integrase; Provisional; Region: PRK09692 944547004034 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 944547004035 active site 944547004036 Int/Topo IB signature motif; other site 944547004037 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 944547004038 IHF dimer interface [polypeptide binding]; other site 944547004039 IHF - DNA interface [nucleotide binding]; other site 944547004040 hypothetical protein; Provisional; Region: PRK05834 944547004041 MraW methylase family; Region: Methyltransf_5; cl17771 944547004042 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 944547004043 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 944547004044 Protein export membrane protein; Region: SecD_SecF; cl14618 944547004045 NLPC_P60 stabilising domain, N term; Region: N_NLPC_P60; pfam12912 944547004046 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 944547004047 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 944547004048 NlpC/P60 family; Region: NLPC_P60; cl17555 944547004049 flagellar hook-associated protein FlgK; Provisional; Region: flgK; PRK12715 944547004050 Cytochrome c; Region: Cytochrom_C; cl11414 944547004051 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 944547004052 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 944547004053 acyl-activating enzyme (AAE) consensus motif; other site 944547004054 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 944547004055 acyl-activating enzyme (AAE) consensus motif; other site 944547004056 active site 944547004057 AMP binding site [chemical binding]; other site 944547004058 CoA binding site [chemical binding]; other site 944547004059 MutL protein; Region: MutL; pfam13941 944547004060 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cd00245 944547004061 substrate binding site [chemical binding]; other site 944547004062 B12 cofactor binding site [chemical binding]; other site 944547004063 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 944547004064 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 944547004065 methylaspartate mutase subunit S; Provisional; Region: PRK02261 944547004066 B12 binding site [chemical binding]; other site 944547004067 malate dehydrogenase; Reviewed; Region: PRK06223 944547004068 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 944547004069 NAD(P) binding site [chemical binding]; other site 944547004070 dimer interface [polypeptide binding]; other site 944547004071 tetramer (dimer of dimers) interface [polypeptide binding]; other site 944547004072 substrate binding site [chemical binding]; other site 944547004073 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 944547004074 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 944547004075 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 944547004076 dimerization interface [polypeptide binding]; other site 944547004077 Protein of unknown function; Region: DUF3971; pfam13116 944547004078 AsmA-like C-terminal region; Region: AsmA_1; pfam13109 944547004079 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 944547004080 FtsX-like permease family; Region: FtsX; pfam02687 944547004081 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 944547004082 DEAD/DEAH box helicase; Region: DEAD; pfam00270 944547004083 ATP binding site [chemical binding]; other site 944547004084 putative Mg++ binding site [ion binding]; other site 944547004085 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 944547004086 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 944547004087 nucleotide binding region [chemical binding]; other site 944547004088 ATP-binding site [chemical binding]; other site 944547004089 SEC-C motif; Region: SEC-C; pfam02810 944547004090 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 944547004091 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 944547004092 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 944547004093 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 944547004094 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 944547004095 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 944547004096 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 944547004097 active site 944547004098 NAD binding site [chemical binding]; other site 944547004099 metal binding site [ion binding]; metal-binding site 944547004100 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 944547004101 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 944547004102 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547004103 PAS fold; Region: PAS_3; pfam08447 944547004104 putative active site [active] 944547004105 heme pocket [chemical binding]; other site 944547004106 PAS domain; Region: PAS_9; pfam13426 944547004107 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 944547004108 putative active site [active] 944547004109 heme pocket [chemical binding]; other site 944547004110 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 944547004111 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547004112 putative active site [active] 944547004113 heme pocket [chemical binding]; other site 944547004114 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547004115 dimer interface [polypeptide binding]; other site 944547004116 phosphorylation site [posttranslational modification] 944547004117 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547004118 ATP binding site [chemical binding]; other site 944547004119 Mg2+ binding site [ion binding]; other site 944547004120 G-X-G motif; other site 944547004121 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 944547004122 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 944547004123 active site 944547004124 SAM binding site [chemical binding]; other site 944547004125 homodimer interface [polypeptide binding]; other site 944547004126 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 944547004127 [2Fe-2S] cluster binding site [ion binding]; other site 944547004128 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 944547004129 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 944547004130 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 944547004131 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 944547004132 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 944547004133 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 944547004134 [4Fe-4S] binding site [ion binding]; other site 944547004135 molybdopterin cofactor binding site; other site 944547004136 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 944547004137 molybdopterin cofactor binding site; other site 944547004138 Response regulator receiver domain; Region: Response_reg; pfam00072 944547004139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547004140 active site 944547004141 phosphorylation site [posttranslational modification] 944547004142 intermolecular recognition site; other site 944547004143 dimerization interface [polypeptide binding]; other site 944547004144 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547004145 PAS domain; Region: PAS_9; pfam13426 944547004146 putative active site [active] 944547004147 heme pocket [chemical binding]; other site 944547004148 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 944547004149 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 944547004150 active site 944547004151 Catalytic domain of Protein Kinases; Region: PKc; cd00180 944547004152 active site 944547004153 ATP binding site [chemical binding]; other site 944547004154 substrate binding site [chemical binding]; other site 944547004155 activation loop (A-loop); other site 944547004156 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 944547004157 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 944547004158 putative substrate translocation pore; other site 944547004159 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 944547004160 hypothetical protein; Provisional; Region: PRK04081 944547004161 NMT1/THI5 like; Region: NMT1; pfam09084 944547004162 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 944547004163 PAS fold; Region: PAS_4; pfam08448 944547004164 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547004165 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547004166 metal binding site [ion binding]; metal-binding site 944547004167 active site 944547004168 I-site; other site 944547004169 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 944547004170 potential frameshift: common BLAST hit: gi|157737409|ref|YP_001490092.1| two-component sensor histidine kinase 944547004171 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 944547004172 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 944547004173 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 944547004174 Histidine kinase; Region: HisKA_2; pfam07568 944547004175 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547004176 ATP binding site [chemical binding]; other site 944547004177 Mg2+ binding site [ion binding]; other site 944547004178 G-X-G motif; other site 944547004179 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547004180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547004181 active site 944547004182 phosphorylation site [posttranslational modification] 944547004183 intermolecular recognition site; other site 944547004184 dimerization interface [polypeptide binding]; other site 944547004185 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 944547004186 DNA binding site [nucleotide binding] 944547004187 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547004188 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547004189 active site 944547004190 phosphorylation site [posttranslational modification] 944547004191 intermolecular recognition site; other site 944547004192 dimerization interface [polypeptide binding]; other site 944547004193 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 944547004194 DNA binding site [nucleotide binding] 944547004195 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 944547004196 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 944547004197 active site 944547004198 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 944547004199 active site 2 [active] 944547004200 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 944547004201 active site 944547004202 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 944547004203 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 944547004204 catalytic nucleophile [active] 944547004205 Protein of unknown function (DUF1826); Region: DUF1826; pfam08856 944547004206 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 944547004207 Restriction endonuclease EcoRI; Region: EcoRI; pfam02963 944547004208 Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651 944547004209 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 944547004210 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 944547004211 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 944547004212 shikimate binding site; other site 944547004213 NAD(P) binding site [chemical binding]; other site 944547004214 Methyltransferase domain; Region: Methyltransf_31; pfam13847 944547004215 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944547004216 S-adenosylmethionine binding site [chemical binding]; other site 944547004217 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 944547004218 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 944547004219 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 944547004220 Malic enzyme, N-terminal domain; Region: malic; pfam00390 944547004221 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 944547004222 putative NAD(P) binding site [chemical binding]; other site 944547004223 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 944547004224 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 944547004225 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 944547004226 putative active site [active] 944547004227 putative substrate binding site [chemical binding]; other site 944547004228 putative cosubstrate binding site; other site 944547004229 catalytic site [active] 944547004230 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 944547004231 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 944547004232 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 944547004233 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547004234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547004235 active site 944547004236 phosphorylation site [posttranslational modification] 944547004237 intermolecular recognition site; other site 944547004238 dimerization interface [polypeptide binding]; other site 944547004239 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 944547004240 DNA binding site [nucleotide binding] 944547004241 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547004242 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547004243 phosphorylation site [posttranslational modification] 944547004244 dimer interface [polypeptide binding]; other site 944547004245 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547004246 ATP binding site [chemical binding]; other site 944547004247 Mg2+ binding site [ion binding]; other site 944547004248 G-X-G motif; other site 944547004249 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 944547004250 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 944547004251 Uncharacterized conserved protein [Function unknown]; Region: COG1433 944547004252 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 944547004253 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 944547004254 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 944547004255 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 944547004256 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 944547004257 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 944547004258 peroxiredoxin; Region: AhpC; TIGR03137 944547004259 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 944547004260 dimer interface [polypeptide binding]; other site 944547004261 decamer (pentamer of dimers) interface [polypeptide binding]; other site 944547004262 catalytic triad [active] 944547004263 peroxidatic and resolving cysteines [active] 944547004264 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 944547004265 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 944547004266 N-terminal plug; other site 944547004267 ligand-binding site [chemical binding]; other site 944547004268 4Fe-4S binding domain; Region: Fer4_5; pfam12801 944547004269 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 944547004270 tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805 944547004271 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 944547004272 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 944547004273 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 944547004274 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 944547004275 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 944547004276 active site 944547004277 metal binding site [ion binding]; metal-binding site 944547004278 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 944547004279 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 944547004280 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 944547004281 Walker A/P-loop; other site 944547004282 ATP binding site [chemical binding]; other site 944547004283 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 944547004284 ABC transporter signature motif; other site 944547004285 Walker B; other site 944547004286 D-loop; other site 944547004287 H-loop/switch region; other site 944547004288 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 944547004289 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 944547004290 active site 944547004291 NTP binding site [chemical binding]; other site 944547004292 metal binding triad [ion binding]; metal-binding site 944547004293 antibiotic binding site [chemical binding]; other site 944547004294 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 944547004295 Catalytic site [active] 944547004296 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 944547004297 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 944547004298 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944547004299 S-adenosylmethionine binding site [chemical binding]; other site 944547004300 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 944547004301 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 944547004302 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 944547004303 active site 944547004304 uracil binding [chemical binding]; other site 944547004305 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 944547004306 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 944547004307 motif II; other site 944547004308 Family description; Region: DsbD_2; pfam13386 944547004309 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 944547004310 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 944547004311 N-terminal plug; other site 944547004312 ligand-binding site [chemical binding]; other site 944547004313 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 944547004314 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 944547004315 intersubunit interface [polypeptide binding]; other site 944547004316 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 944547004317 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 944547004318 Walker A/P-loop; other site 944547004319 ATP binding site [chemical binding]; other site 944547004320 Q-loop/lid; other site 944547004321 ABC transporter signature motif; other site 944547004322 Walker B; other site 944547004323 D-loop; other site 944547004324 H-loop/switch region; other site 944547004325 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 944547004326 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 944547004327 ABC-ATPase subunit interface; other site 944547004328 dimer interface [polypeptide binding]; other site 944547004329 putative PBP binding regions; other site 944547004330 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 944547004331 catalytic core [active] 944547004332 Protein of unknown function, DUF479; Region: DUF479; cl01203 944547004333 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 944547004334 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323 944547004335 gating phenylalanine in ion channel; other site 944547004336 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 944547004337 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 944547004338 active site 944547004339 catalytic tetrad [active] 944547004340 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 944547004341 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944547004342 dimer interface [polypeptide binding]; other site 944547004343 putative CheW interface [polypeptide binding]; other site 944547004344 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 944547004345 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 944547004346 active site 944547004347 nuclease NucT; Provisional; Region: PRK13912 944547004348 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 944547004349 putative active site [active] 944547004350 catalytic site [active] 944547004351 Peptidase family M48; Region: Peptidase_M48; pfam01435 944547004352 RmuC family; Region: RmuC; pfam02646 944547004353 Predicted permeases [General function prediction only]; Region: COG0701 944547004354 Predicted metalloprotease [General function prediction only]; Region: COG2321 944547004355 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 944547004356 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 944547004357 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 944547004358 dimer interface [polypeptide binding]; other site 944547004359 putative functional site; other site 944547004360 putative MPT binding site; other site 944547004361 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 944547004362 Coenzyme A binding pocket [chemical binding]; other site 944547004363 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 944547004364 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 944547004365 Ligand Binding Site [chemical binding]; other site 944547004366 Uncharacterized conserved protein [Function unknown]; Region: COG1683 944547004367 thioredoxin 2; Provisional; Region: PRK10996 944547004368 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 944547004369 catalytic residues [active] 944547004370 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 944547004371 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 944547004372 Helix-turn-helix domain; Region: HTH_38; pfam13936 944547004373 Homeodomain-like domain; Region: HTH_32; pfam13565 944547004374 Integrase core domain; Region: rve; pfam00665 944547004375 Integrase core domain; Region: rve_3; cl15866 944547004376 SprA-related family; Region: SprA-related; pfam12118 944547004377 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547004378 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547004379 metal binding site [ion binding]; metal-binding site 944547004380 active site 944547004381 I-site; other site 944547004382 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 944547004383 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 944547004384 exopolyphosphatase; Region: exo_poly_only; TIGR03706 944547004385 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 944547004386 nucleotide binding site [chemical binding]; other site 944547004387 flagellin B; Provisional; Region: PRK13588 944547004388 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK08527 944547004389 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 944547004390 PYR/PP interface [polypeptide binding]; other site 944547004391 dimer interface [polypeptide binding]; other site 944547004392 TPP binding site [chemical binding]; other site 944547004393 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 944547004394 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 944547004395 TPP-binding site [chemical binding]; other site 944547004396 dimer interface [polypeptide binding]; other site 944547004397 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 944547004398 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 944547004399 putative valine binding site [chemical binding]; other site 944547004400 dimer interface [polypeptide binding]; other site 944547004401 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 944547004402 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 944547004403 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 944547004404 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 944547004405 trimer interface [polypeptide binding]; other site 944547004406 active site 944547004407 UDP-GlcNAc binding site [chemical binding]; other site 944547004408 lipid binding site [chemical binding]; lipid-binding site 944547004409 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 944547004410 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 944547004411 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 944547004412 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547004413 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547004414 active site 944547004415 phosphorylation site [posttranslational modification] 944547004416 intermolecular recognition site; other site 944547004417 dimerization interface [polypeptide binding]; other site 944547004418 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 944547004419 DNA binding site [nucleotide binding] 944547004420 dimerization interface [polypeptide binding]; other site 944547004421 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 944547004422 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547004423 ATP binding site [chemical binding]; other site 944547004424 Mg2+ binding site [ion binding]; other site 944547004425 G-X-G motif; other site 944547004426 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 944547004427 flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506 944547004428 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 944547004429 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 944547004430 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 944547004431 Flagellar hook-associated protein [Cell motility and secretion]; Region: FlgK; COG1256 944547004432 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 944547004433 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 944547004434 flagellar capping protein; Reviewed; Region: fliD; PRK08032 944547004435 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 944547004436 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 944547004437 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 944547004438 30S subunit binding site; other site 944547004439 GTP-binding protein Der; Reviewed; Region: PRK00093 944547004440 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 944547004441 G1 box; other site 944547004442 GTP/Mg2+ binding site [chemical binding]; other site 944547004443 Switch I region; other site 944547004444 G2 box; other site 944547004445 Switch II region; other site 944547004446 G3 box; other site 944547004447 G4 box; other site 944547004448 G5 box; other site 944547004449 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 944547004450 G1 box; other site 944547004451 GTP/Mg2+ binding site [chemical binding]; other site 944547004452 Switch I region; other site 944547004453 G2 box; other site 944547004454 G3 box; other site 944547004455 Switch II region; other site 944547004456 G4 box; other site 944547004457 G5 box; other site 944547004458 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 944547004459 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 944547004460 Sulfate transporter family; Region: Sulfate_transp; pfam00916 944547004461 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 944547004462 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 944547004463 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 944547004464 active site 944547004465 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 944547004466 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 944547004467 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 944547004468 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 944547004469 RDD family; Region: RDD; pfam06271 944547004470 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 944547004471 Organic solvent tolerance protein; Region: OstA_C; pfam04453 944547004472 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 944547004473 active site 944547004474 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 944547004475 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 944547004476 oligomer interface [polypeptide binding]; other site 944547004477 RNA binding site [nucleotide binding]; other site 944547004478 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 944547004479 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 944547004480 oligomer interface [polypeptide binding]; other site 944547004481 RNA binding site [nucleotide binding]; other site 944547004482 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 944547004483 putative nucleic acid binding region [nucleotide binding]; other site 944547004484 G-X-X-G motif; other site 944547004485 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 944547004486 RNA binding site [nucleotide binding]; other site 944547004487 domain interface; other site 944547004488 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 944547004489 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547004490 active site 944547004491 phosphorylation site [posttranslational modification] 944547004492 intermolecular recognition site; other site 944547004493 dimerization interface [polypeptide binding]; other site 944547004494 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 944547004495 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 944547004496 putative binding surface; other site 944547004497 active site 944547004498 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 944547004499 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547004500 ATP binding site [chemical binding]; other site 944547004501 Mg2+ binding site [ion binding]; other site 944547004502 G-X-G motif; other site 944547004503 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 944547004504 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 944547004505 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 944547004506 CheD chemotactic sensory transduction; Region: CheD; cl00810 944547004507 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 944547004508 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547004509 active site 944547004510 phosphorylation site [posttranslational modification] 944547004511 intermolecular recognition site; other site 944547004512 dimerization interface [polypeptide binding]; other site 944547004513 CheB methylesterase; Region: CheB_methylest; pfam01339 944547004514 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 944547004515 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 944547004516 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 944547004517 active site 944547004518 DNA binding site [nucleotide binding] 944547004519 Int/Topo IB signature motif; other site 944547004520 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 944547004521 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 944547004522 putative active site [active] 944547004523 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 944547004524 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 944547004525 active site 944547004526 Zn binding site [ion binding]; other site 944547004527 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 944547004528 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944547004529 S-adenosylmethionine binding site [chemical binding]; other site 944547004530 coproporphyrinogen III oxidase; Provisional; Region: PRK08446 944547004531 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 944547004532 putative active site [active] 944547004533 Ap4A binding site [chemical binding]; other site 944547004534 nudix motif; other site 944547004535 putative metal binding site [ion binding]; other site 944547004536 aspartate kinase; Reviewed; Region: PRK06635 944547004537 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 944547004538 putative nucleotide binding site [chemical binding]; other site 944547004539 putative catalytic residues [active] 944547004540 putative Mg ion binding site [ion binding]; other site 944547004541 putative aspartate binding site [chemical binding]; other site 944547004542 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 944547004543 putative allosteric regulatory site; other site 944547004544 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 944547004545 DNA replication regulator; Region: HobA; pfam12163 944547004546 DNA polymerase III subunit delta'; Validated; Region: PRK08485 944547004547 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 944547004548 dihydropteroate synthase; Region: DHPS; TIGR01496 944547004549 substrate binding pocket [chemical binding]; other site 944547004550 dimer interface [polypeptide binding]; other site 944547004551 inhibitor binding site; inhibition site 944547004552 prephenate dehydrogenase; Validated; Region: PRK08507 944547004553 Prephenate dehydrogenase; Region: PDH; pfam02153 944547004554 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 944547004555 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 944547004556 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 944547004557 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 944547004558 Surface antigen; Region: Bac_surface_Ag; pfam01103 944547004559 hypothetical protein; Provisional; Region: PRK08445 944547004560 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 944547004561 FeS/SAM binding site; other site 944547004562 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 944547004563 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 944547004564 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 944547004565 glutamylglutaminyl-tRNA synthetase; Provisional; Region: PRK12410 944547004566 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 944547004567 active site 944547004568 HIGH motif; other site 944547004569 nucleotide binding site [chemical binding]; other site 944547004570 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 944547004571 active site 944547004572 KMSKS motif; other site 944547004573 YGGT family; Region: YGGT; pfam02325 944547004574 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 944547004575 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 944547004576 N-acetyl-D-glucosamine binding site [chemical binding]; other site 944547004577 catalytic residue [active] 944547004578 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 944547004579 Walker A motif; other site 944547004580 fructose-1,6-bisphosphatase; Provisional; Region: PRK09293 944547004581 active site 944547004582 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 944547004583 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 944547004584 active site 944547004585 HIGH motif; other site 944547004586 KMSKS motif; other site 944547004587 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 944547004588 anticodon binding site; other site 944547004589 tRNA binding surface [nucleotide binding]; other site 944547004590 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 944547004591 dimer interface [polypeptide binding]; other site 944547004592 putative tRNA-binding site [nucleotide binding]; other site 944547004593 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 944547004594 ribosomal biogenesis protein; Validated; Region: PRK00933 944547004595 Predicted transcriptional regulator [Transcription]; Region: COG2932 944547004596 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 944547004597 Catalytic site [active] 944547004598 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277 944547004599 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 944547004600 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 944547004601 active site 944547004602 catalytic residues [active] 944547004603 metal binding site [ion binding]; metal-binding site 944547004604 homodimer binding site [polypeptide binding]; other site 944547004605 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 944547004606 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 944547004607 carboxyltransferase (CT) interaction site; other site 944547004608 biotinylation site [posttranslational modification]; other site 944547004609 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 944547004610 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 944547004611 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 944547004612 active site 944547004613 substrate-binding site [chemical binding]; other site 944547004614 metal-binding site [ion binding] 944547004615 ATP binding site [chemical binding]; other site 944547004616 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09314 944547004617 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 944547004618 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 944547004619 Gram-negative bacterial tonB protein; Region: TonB; cl10048 944547004620 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 944547004621 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 944547004622 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 944547004623 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 944547004624 Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069 944547004625 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 944547004626 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 944547004627 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 944547004628 dimerization interface [polypeptide binding]; other site 944547004629 active site 944547004630 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 944547004631 dimer interface [polypeptide binding]; other site 944547004632 active site 944547004633 Schiff base residues; other site 944547004634 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547004635 PAS domain; Region: PAS_9; pfam13426 944547004636 putative active site [active] 944547004637 heme pocket [chemical binding]; other site 944547004638 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 944547004639 dimer interface [polypeptide binding]; other site 944547004640 phosphorylation site [posttranslational modification] 944547004641 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547004642 ATP binding site [chemical binding]; other site 944547004643 Mg2+ binding site [ion binding]; other site 944547004644 G-X-G motif; other site 944547004645 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547004646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547004647 active site 944547004648 phosphorylation site [posttranslational modification] 944547004649 intermolecular recognition site; other site 944547004650 dimerization interface [polypeptide binding]; other site 944547004651 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 944547004652 DNA binding site [nucleotide binding] 944547004653 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 944547004654 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 944547004655 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 944547004656 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 944547004657 ATP cone domain; Region: ATP-cone; pfam03477 944547004658 Class III ribonucleotide reductase; Region: RNR_III; cd01675 944547004659 effector binding site; other site 944547004660 active site 944547004661 Zn binding site [ion binding]; other site 944547004662 ornithine carbamoyltransferase; Provisional; Region: PRK00779 944547004663 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 944547004664 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 944547004665 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 944547004666 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 944547004667 FeS/SAM binding site; other site 944547004668 HemN C-terminal domain; Region: HemN_C; pfam06969 944547004669 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 944547004670 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 944547004671 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 944547004672 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 944547004673 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 944547004674 inhibitor-cofactor binding pocket; inhibition site 944547004675 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944547004676 catalytic residue [active] 944547004677 NAD synthetase; Provisional; Region: PRK13980 944547004678 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 944547004679 homodimer interface [polypeptide binding]; other site 944547004680 NAD binding pocket [chemical binding]; other site 944547004681 ATP binding pocket [chemical binding]; other site 944547004682 Mg binding site [ion binding]; other site 944547004683 active-site loop [active] 944547004684 hypothetical protein; Provisional; Region: PRK04351 944547004685 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 944547004686 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 944547004687 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 944547004688 putative metal binding site [ion binding]; other site 944547004689 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 944547004690 HSP70 interaction site [polypeptide binding]; other site 944547004691 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 944547004692 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 944547004693 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 944547004694 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 944547004695 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 944547004696 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 944547004697 active site 944547004698 catalytic site [active] 944547004699 substrate binding site [chemical binding]; other site 944547004700 Competence protein; Region: Competence; pfam03772 944547004701 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 944547004702 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 944547004703 Methyltransferase domain; Region: Methyltransf_31; pfam13847 944547004704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944547004705 S-adenosylmethionine binding site [chemical binding]; other site 944547004706 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 944547004707 putative active site pocket [active] 944547004708 dimerization interface [polypeptide binding]; other site 944547004709 putative catalytic residue [active] 944547004710 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 944547004711 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 944547004712 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 944547004713 Cysteine-rich domain; Region: CCG; pfam02754 944547004714 Cysteine-rich domain; Region: CCG; pfam02754 944547004715 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 944547004716 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547004717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547004718 active site 944547004719 phosphorylation site [posttranslational modification] 944547004720 intermolecular recognition site; other site 944547004721 dimerization interface [polypeptide binding]; other site 944547004722 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 944547004723 DNA polymerase I; Provisional; Region: PRK05755 944547004724 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 944547004725 active site 944547004726 metal binding site 1 [ion binding]; metal-binding site 944547004727 putative 5' ssDNA interaction site; other site 944547004728 metal binding site 3; metal-binding site 944547004729 metal binding site 2 [ion binding]; metal-binding site 944547004730 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 944547004731 putative DNA binding site [nucleotide binding]; other site 944547004732 putative metal binding site [ion binding]; other site 944547004733 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 944547004734 active site 944547004735 catalytic site [active] 944547004736 substrate binding site [chemical binding]; other site 944547004737 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 944547004738 active site 944547004739 DNA binding site [nucleotide binding] 944547004740 catalytic site [active] 944547004741 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 944547004742 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 944547004743 Ligand binding site; other site 944547004744 oligomer interface; other site 944547004745 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547004746 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547004747 metal binding site [ion binding]; metal-binding site 944547004748 active site 944547004749 I-site; other site 944547004750 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 944547004751 Response regulator receiver domain; Region: Response_reg; pfam00072 944547004752 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547004753 active site 944547004754 phosphorylation site [posttranslational modification] 944547004755 intermolecular recognition site; other site 944547004756 dimerization interface [polypeptide binding]; other site 944547004757 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547004758 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547004759 metal binding site [ion binding]; metal-binding site 944547004760 active site 944547004761 I-site; other site 944547004762 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 944547004763 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 944547004764 Walker A/P-loop; other site 944547004765 ATP binding site [chemical binding]; other site 944547004766 Q-loop/lid; other site 944547004767 ABC transporter signature motif; other site 944547004768 Walker B; other site 944547004769 D-loop; other site 944547004770 H-loop/switch region; other site 944547004771 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 944547004772 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 944547004773 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 944547004774 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 944547004775 RNA binding surface [nucleotide binding]; other site 944547004776 argininosuccinate synthase; Provisional; Region: PRK13820 944547004777 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 944547004778 ANP binding site [chemical binding]; other site 944547004779 Substrate Binding Site II [chemical binding]; other site 944547004780 Substrate Binding Site I [chemical binding]; other site 944547004781 glutamate carboxypeptidase; Reviewed; Region: PRK06133 944547004782 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 944547004783 metal binding site [ion binding]; metal-binding site 944547004784 dimer interface [polypeptide binding]; other site 944547004785 ATP-grasp domain; Region: ATP-grasp_4; cl17255 944547004786 ATP-grasp domain; Region: ATP-grasp_4; cl17255 944547004787 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 944547004788 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 944547004789 active site 944547004790 Zn binding site [ion binding]; other site 944547004791 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 944547004792 Interdomain contacts; other site 944547004793 Cytokine receptor motif; other site 944547004794 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 944547004795 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 944547004796 trimer interface [polypeptide binding]; other site 944547004797 putative metal binding site [ion binding]; other site 944547004798 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 944547004799 TrkA-N domain; Region: TrkA_N; pfam02254 944547004800 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 944547004801 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 944547004802 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547004803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547004804 active site 944547004805 phosphorylation site [posttranslational modification] 944547004806 intermolecular recognition site; other site 944547004807 dimerization interface [polypeptide binding]; other site 944547004808 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 944547004809 DNA binding site [nucleotide binding] 944547004810 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 944547004811 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547004812 dimer interface [polypeptide binding]; other site 944547004813 phosphorylation site [posttranslational modification] 944547004814 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547004815 ATP binding site [chemical binding]; other site 944547004816 Mg2+ binding site [ion binding]; other site 944547004817 G-X-G motif; other site 944547004818 dUTPase; Region: dUTPase_2; pfam08761 944547004819 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 944547004820 active site 944547004821 homodimer interface [polypeptide binding]; other site 944547004822 metal binding site [ion binding]; metal-binding site 944547004823 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547004824 PAS domain; Region: PAS_9; pfam13426 944547004825 putative active site [active] 944547004826 heme pocket [chemical binding]; other site 944547004827 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547004828 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547004829 dimer interface [polypeptide binding]; other site 944547004830 phosphorylation site [posttranslational modification] 944547004831 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547004832 ATP binding site [chemical binding]; other site 944547004833 Mg2+ binding site [ion binding]; other site 944547004834 G-X-G motif; other site 944547004835 recombination protein RecR; Reviewed; Region: recR; PRK00076 944547004836 RecR protein; Region: RecR; pfam02132 944547004837 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 944547004838 putative active site [active] 944547004839 putative metal-binding site [ion binding]; other site 944547004840 tetramer interface [polypeptide binding]; other site 944547004841 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 944547004842 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 944547004843 chaperone protein DnaJ; Provisional; Region: PRK10767 944547004844 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 944547004845 HSP70 interaction site [polypeptide binding]; other site 944547004846 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 944547004847 substrate binding site [polypeptide binding]; other site 944547004848 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 944547004849 Zn binding sites [ion binding]; other site 944547004850 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 944547004851 dimer interface [polypeptide binding]; other site 944547004852 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 944547004853 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 944547004854 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944547004855 catalytic residue [active] 944547004856 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 944547004857 dinuclear metal binding motif [ion binding]; other site 944547004858 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 944547004859 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547004860 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547004861 metal binding site [ion binding]; metal-binding site 944547004862 active site 944547004863 I-site; other site 944547004864 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547004865 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547004866 metal binding site [ion binding]; metal-binding site 944547004867 active site 944547004868 I-site; other site 944547004869 Methyltransferase domain; Region: Methyltransf_23; pfam13489 944547004870 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944547004871 S-adenosylmethionine binding site [chemical binding]; other site 944547004872 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 944547004873 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 944547004874 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547004875 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547004876 active site 944547004877 phosphorylation site [posttranslational modification] 944547004878 intermolecular recognition site; other site 944547004879 dimerization interface [polypeptide binding]; other site 944547004880 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 944547004881 DNA binding site [nucleotide binding] 944547004882 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 944547004883 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 944547004884 substrate binding pocket [chemical binding]; other site 944547004885 membrane-bound complex binding site; other site 944547004886 hinge residues; other site 944547004887 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 944547004888 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 944547004889 substrate binding pocket [chemical binding]; other site 944547004890 membrane-bound complex binding site; other site 944547004891 hinge residues; other site 944547004892 PAS domain S-box; Region: sensory_box; TIGR00229 944547004893 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547004894 putative active site [active] 944547004895 heme pocket [chemical binding]; other site 944547004896 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547004897 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547004898 dimer interface [polypeptide binding]; other site 944547004899 phosphorylation site [posttranslational modification] 944547004900 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547004901 ATP binding site [chemical binding]; other site 944547004902 Mg2+ binding site [ion binding]; other site 944547004903 G-X-G motif; other site 944547004904 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 944547004905 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 944547004906 metal binding site [ion binding]; metal-binding site 944547004907 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944547004908 dimer interface [polypeptide binding]; other site 944547004909 putative CheW interface [polypeptide binding]; other site 944547004910 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 944547004911 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 944547004912 nucleotide binding pocket [chemical binding]; other site 944547004913 K-X-D-G motif; other site 944547004914 catalytic site [active] 944547004915 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 944547004916 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 944547004917 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 944547004918 Dimer interface [polypeptide binding]; other site 944547004919 BRCT sequence motif; other site 944547004920 Cache domain; Region: Cache_1; pfam02743 944547004921 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547004922 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547004923 dimer interface [polypeptide binding]; other site 944547004924 phosphorylation site [posttranslational modification] 944547004925 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547004926 ATP binding site [chemical binding]; other site 944547004927 Mg2+ binding site [ion binding]; other site 944547004928 G-X-G motif; other site 944547004929 Response regulator receiver domain; Region: Response_reg; pfam00072 944547004930 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547004931 active site 944547004932 phosphorylation site [posttranslational modification] 944547004933 intermolecular recognition site; other site 944547004934 dimerization interface [polypeptide binding]; other site 944547004935 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 944547004936 dimer interface [polypeptide binding]; other site 944547004937 phosphorylation site [posttranslational modification] 944547004938 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547004939 ATP binding site [chemical binding]; other site 944547004940 Mg2+ binding site [ion binding]; other site 944547004941 G-X-G motif; other site 944547004942 Response regulator receiver domain; Region: Response_reg; pfam00072 944547004943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547004944 active site 944547004945 phosphorylation site [posttranslational modification] 944547004946 intermolecular recognition site; other site 944547004947 dimerization interface [polypeptide binding]; other site 944547004948 PAS domain; Region: PAS_9; pfam13426 944547004949 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547004950 putative active site [active] 944547004951 heme pocket [chemical binding]; other site 944547004952 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547004953 PAS domain; Region: PAS_9; pfam13426 944547004954 putative active site [active] 944547004955 heme pocket [chemical binding]; other site 944547004956 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 944547004957 Zn2+ binding site [ion binding]; other site 944547004958 Mg2+ binding site [ion binding]; other site 944547004959 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 944547004960 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 944547004961 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 944547004962 Walker A/P-loop; other site 944547004963 ATP binding site [chemical binding]; other site 944547004964 Q-loop/lid; other site 944547004965 ABC transporter signature motif; other site 944547004966 Walker B; other site 944547004967 D-loop; other site 944547004968 H-loop/switch region; other site 944547004969 ABC transporter; Region: ABC_tran_2; pfam12848 944547004970 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 944547004971 E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387 944547004972 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 944547004973 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 944547004974 dimer interface [polypeptide binding]; other site 944547004975 active site 944547004976 metal binding site [ion binding]; metal-binding site 944547004977 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 944547004978 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 944547004979 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 944547004980 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 944547004981 NMT1/THI5 like; Region: NMT1; pfam09084 944547004982 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 944547004983 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 944547004984 substrate binding pocket [chemical binding]; other site 944547004985 membrane-bound complex binding site; other site 944547004986 hinge residues; other site 944547004987 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 944547004988 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 944547004989 substrate binding pocket [chemical binding]; other site 944547004990 membrane-bound complex binding site; other site 944547004991 hinge residues; other site 944547004992 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547004993 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547004994 metal binding site [ion binding]; metal-binding site 944547004995 active site 944547004996 I-site; other site 944547004997 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547004998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547004999 active site 944547005000 phosphorylation site [posttranslational modification] 944547005001 intermolecular recognition site; other site 944547005002 dimerization interface [polypeptide binding]; other site 944547005003 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 944547005004 DNA binding site [nucleotide binding] 944547005005 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 944547005006 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 944547005007 ATP binding site [chemical binding]; other site 944547005008 Mg2+ binding site [ion binding]; other site 944547005009 G-X-G motif; other site 944547005010 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 944547005011 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 944547005012 PAS domain S-box; Region: sensory_box; TIGR00229 944547005013 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547005014 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547005015 dimer interface [polypeptide binding]; other site 944547005016 phosphorylation site [posttranslational modification] 944547005017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547005018 ATP binding site [chemical binding]; other site 944547005019 G-X-G motif; other site 944547005020 Bacterial virulence factor haemolysin; Region: SMP_2; cl11479 944547005021 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 944547005022 dimerization interface [polypeptide binding]; other site 944547005023 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547005024 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547005025 ATP binding site [chemical binding]; other site 944547005026 Mg2+ binding site [ion binding]; other site 944547005027 G-X-G motif; other site 944547005028 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 944547005029 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 944547005030 DNA binding site [nucleotide binding] 944547005031 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 944547005032 FMN binding site [chemical binding]; other site 944547005033 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 944547005034 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 944547005035 EamA-like transporter family; Region: EamA; pfam00892 944547005036 EamA-like transporter family; Region: EamA; pfam00892 944547005037 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 944547005038 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 944547005039 active site 944547005040 FMN binding site [chemical binding]; other site 944547005041 substrate binding site [chemical binding]; other site 944547005042 homotetramer interface [polypeptide binding]; other site 944547005043 catalytic residue [active] 944547005044 Uncharacterized conserved protein [Function unknown]; Region: COG1359 944547005045 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 944547005046 Predicted transcriptional regulators [Transcription]; Region: COG1733 944547005047 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 944547005048 dimerization interface [polypeptide binding]; other site 944547005049 putative DNA binding site [nucleotide binding]; other site 944547005050 putative Zn2+ binding site [ion binding]; other site 944547005051 Membrane transport protein; Region: Mem_trans; cl09117 944547005052 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 944547005053 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 944547005054 dimerization domain [polypeptide binding]; other site 944547005055 dimer interface [polypeptide binding]; other site 944547005056 catalytic residues [active] 944547005057 Predicted membrane protein [Function unknown]; Region: COG2855 944547005058 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 944547005059 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 944547005060 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 944547005061 dimerization interface [polypeptide binding]; other site 944547005062 Sensory domain found in PocR; Region: PocR; pfam10114 944547005063 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 944547005064 PAS domain S-box; Region: sensory_box; TIGR00229 944547005065 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547005066 putative active site [active] 944547005067 heme pocket [chemical binding]; other site 944547005068 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 944547005069 GAF domain; Region: GAF; pfam01590 944547005070 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547005071 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547005072 metal binding site [ion binding]; metal-binding site 944547005073 active site 944547005074 I-site; other site 944547005075 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 944547005076 substrate binding site [chemical binding]; other site 944547005077 Helix-turn-helix domain; Region: HTH_18; pfam12833 944547005078 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 944547005079 NMT1/THI5 like; Region: NMT1; pfam09084 944547005080 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 944547005081 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 944547005082 substrate binding pocket [chemical binding]; other site 944547005083 membrane-bound complex binding site; other site 944547005084 hinge residues; other site 944547005085 PAS domain; Region: PAS_9; pfam13426 944547005086 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547005087 putative active site [active] 944547005088 heme pocket [chemical binding]; other site 944547005089 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547005090 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547005091 metal binding site [ion binding]; metal-binding site 944547005092 active site 944547005093 I-site; other site 944547005094 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 944547005095 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 944547005096 active site 944547005097 catalytic tetrad [active] 944547005098 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 944547005099 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 944547005100 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 944547005101 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 944547005102 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 944547005103 ligand binding site [chemical binding]; other site 944547005104 flexible hinge region; other site 944547005105 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547005106 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 944547005107 dimer interface [polypeptide binding]; other site 944547005108 phosphorylation site [posttranslational modification] 944547005109 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547005110 ATP binding site [chemical binding]; other site 944547005111 Mg2+ binding site [ion binding]; other site 944547005112 G-X-G motif; other site 944547005113 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 944547005114 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 944547005115 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 944547005116 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 944547005117 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 944547005118 PhnA protein; Region: PhnA; pfam03831 944547005119 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 944547005120 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 944547005121 tetramer interface [polypeptide binding]; other site 944547005122 catalytic Zn binding site [ion binding]; other site 944547005123 NADP binding site [chemical binding]; other site 944547005124 lipoyl synthase; Provisional; Region: PRK05481 944547005125 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 944547005126 FeS/SAM binding site; other site 944547005127 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 944547005128 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 944547005129 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 944547005130 dimer interface [polypeptide binding]; other site 944547005131 TPP-binding site [chemical binding]; other site 944547005132 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 944547005133 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 944547005134 E3 interaction surface; other site 944547005135 lipoyl attachment site [posttranslational modification]; other site 944547005136 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 944547005137 E3 interaction surface; other site 944547005138 lipoyl attachment site [posttranslational modification]; other site 944547005139 e3 binding domain; Region: E3_binding; pfam02817 944547005140 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 944547005141 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 944547005142 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 944547005143 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 944547005144 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 944547005145 potential frameshift: common BLAST hit: gi|157737386|ref|YP_001490069.1| ABC transporter, ATP-binding protein 944547005146 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 944547005147 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 944547005148 Walker B; other site 944547005149 D-loop; other site 944547005150 H-loop/switch region; other site 944547005151 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 944547005152 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547005153 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547005154 metal binding site [ion binding]; metal-binding site 944547005155 active site 944547005156 I-site; other site 944547005157 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 944547005158 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 944547005159 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 944547005160 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 944547005161 dimer interface [polypeptide binding]; other site 944547005162 ligand binding site [chemical binding]; other site 944547005163 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 944547005164 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 944547005165 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 944547005166 Coenzyme A binding pocket [chemical binding]; other site 944547005167 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 944547005168 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 944547005169 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 944547005170 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 944547005171 Coenzyme A binding pocket [chemical binding]; other site 944547005172 Chorismate mutase type II; Region: CM_2; smart00830 944547005173 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 944547005174 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 944547005175 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 944547005176 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 944547005177 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 944547005178 Walker A/P-loop; other site 944547005179 ATP binding site [chemical binding]; other site 944547005180 Q-loop/lid; other site 944547005181 ABC transporter signature motif; other site 944547005182 Walker B; other site 944547005183 D-loop; other site 944547005184 H-loop/switch region; other site 944547005185 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547005186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547005187 active site 944547005188 phosphorylation site [posttranslational modification] 944547005189 intermolecular recognition site; other site 944547005190 dimerization interface [polypeptide binding]; other site 944547005191 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 944547005192 DNA binding site [nucleotide binding] 944547005193 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 944547005194 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 944547005195 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547005196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547005197 ATP binding site [chemical binding]; other site 944547005198 G-X-G motif; other site 944547005199 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 944547005200 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 944547005201 metal binding site [ion binding]; metal-binding site 944547005202 dimer interface [polypeptide binding]; other site 944547005203 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 944547005204 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 944547005205 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231 944547005206 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 944547005207 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 944547005208 Walker A/P-loop; other site 944547005209 ATP binding site [chemical binding]; other site 944547005210 Q-loop/lid; other site 944547005211 ABC transporter signature motif; other site 944547005212 Walker B; other site 944547005213 D-loop; other site 944547005214 H-loop/switch region; other site 944547005215 Smr domain; Region: Smr; pfam01713 944547005216 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 944547005217 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 944547005218 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 944547005219 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 944547005220 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 944547005221 MPT binding site; other site 944547005222 trimer interface [polypeptide binding]; other site 944547005223 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 944547005224 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 944547005225 Walker B motif; other site 944547005226 arginine finger; other site 944547005227 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 944547005228 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 944547005229 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 944547005230 Mechanosensitive ion channel; Region: MS_channel; pfam00924 944547005231 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 944547005232 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 944547005233 active site 944547005234 dimer interface [polypeptide binding]; other site 944547005235 metal binding site [ion binding]; metal-binding site 944547005236 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547005237 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547005238 metal binding site [ion binding]; metal-binding site 944547005239 active site 944547005240 I-site; other site 944547005241 EAL domain; Region: EAL; pfam00563 944547005242 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 944547005243 Calx-beta domain; Region: Calx-beta; cl02522 944547005244 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 944547005245 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 944547005246 DNA binding residues [nucleotide binding] 944547005247 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 944547005248 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 944547005249 HlyD family secretion protein; Region: HlyD_3; pfam13437 944547005250 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 944547005251 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 944547005252 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 944547005253 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 944547005254 Walker A/P-loop; other site 944547005255 ATP binding site [chemical binding]; other site 944547005256 Q-loop/lid; other site 944547005257 ABC transporter signature motif; other site 944547005258 Walker B; other site 944547005259 D-loop; other site 944547005260 H-loop/switch region; other site 944547005261 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 944547005262 ligand binding site [chemical binding]; other site 944547005263 OmpA family; Region: OmpA; pfam00691 944547005264 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 944547005265 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 944547005266 ligand binding site [chemical binding]; other site 944547005267 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547005268 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547005269 active site 944547005270 phosphorylation site [posttranslational modification] 944547005271 intermolecular recognition site; other site 944547005272 dimerization interface [polypeptide binding]; other site 944547005273 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 944547005274 DNA binding site [nucleotide binding] 944547005275 NMT1/THI5 like; Region: NMT1; pfam09084 944547005276 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 944547005277 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 944547005278 substrate binding pocket [chemical binding]; other site 944547005279 membrane-bound complex binding site; other site 944547005280 hinge residues; other site 944547005281 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547005282 PAS domain; Region: PAS_9; pfam13426 944547005283 putative active site [active] 944547005284 heme pocket [chemical binding]; other site 944547005285 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547005286 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547005287 ATP binding site [chemical binding]; other site 944547005288 Mg2+ binding site [ion binding]; other site 944547005289 G-X-G motif; other site 944547005290 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 944547005291 putative Mg++ binding site [ion binding]; other site 944547005292 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 944547005293 nucleotide binding region [chemical binding]; other site 944547005294 ATP-binding site [chemical binding]; other site 944547005295 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 944547005296 non-specific DNA binding site [nucleotide binding]; other site 944547005297 salt bridge; other site 944547005298 sequence-specific DNA binding site [nucleotide binding]; other site 944547005299 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547005300 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547005301 metal binding site [ion binding]; metal-binding site 944547005302 active site 944547005303 I-site; other site 944547005304 ferrochelatase; Reviewed; Region: hemH; PRK00035 944547005305 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 944547005306 C-terminal domain interface [polypeptide binding]; other site 944547005307 active site 944547005308 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 944547005309 active site 944547005310 N-terminal domain interface [polypeptide binding]; other site 944547005311 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 944547005312 hydrophobic ligand binding site; other site 944547005313 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 944547005314 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547005315 active site 944547005316 phosphorylation site [posttranslational modification] 944547005317 intermolecular recognition site; other site 944547005318 dimerization interface [polypeptide binding]; other site 944547005319 LytTr DNA-binding domain; Region: LytTR; smart00850 944547005320 Histidine kinase; Region: His_kinase; pfam06580 944547005321 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 944547005322 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 944547005323 carotene isomerase; Region: carot_isom; TIGR02730 944547005324 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 944547005325 DNA photolyase; Region: DNA_photolyase; pfam00875 944547005326 Protein of unknown function (DUF523); Region: DUF523; pfam04463 944547005327 Uncharacterized conserved protein [Function unknown]; Region: COG3272 944547005328 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 944547005329 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 944547005330 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 944547005331 active site 944547005332 catalytic site [active] 944547005333 substrate binding site [chemical binding]; other site 944547005334 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 944547005335 flagellin; Provisional; Region: PRK12802 944547005336 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 944547005337 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 944547005338 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 944547005339 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547005340 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547005341 dimer interface [polypeptide binding]; other site 944547005342 phosphorylation site [posttranslational modification] 944547005343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547005344 ATP binding site [chemical binding]; other site 944547005345 Mg2+ binding site [ion binding]; other site 944547005346 G-X-G motif; other site 944547005347 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547005348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547005349 active site 944547005350 phosphorylation site [posttranslational modification] 944547005351 intermolecular recognition site; other site 944547005352 dimerization interface [polypeptide binding]; other site 944547005353 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 944547005354 DNA binding site [nucleotide binding] 944547005355 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 944547005356 DNA binding site [nucleotide binding] 944547005357 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 944547005358 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 944547005359 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 944547005360 Walker A/P-loop; other site 944547005361 ATP binding site [chemical binding]; other site 944547005362 Q-loop/lid; other site 944547005363 ABC transporter signature motif; other site 944547005364 Walker B; other site 944547005365 D-loop; other site 944547005366 H-loop/switch region; other site 944547005367 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 944547005368 Domain of unknown function DUF20; Region: UPF0118; pfam01594 944547005369 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 944547005370 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 944547005371 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 944547005372 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 944547005373 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 944547005374 catalytic residues [active] 944547005375 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 944547005376 L-lactate permease; Region: Lactate_perm; cl00701 944547005377 PAS domain S-box; Region: sensory_box; TIGR00229 944547005378 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547005379 putative active site [active] 944547005380 heme pocket [chemical binding]; other site 944547005381 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547005382 PAS domain; Region: PAS_9; pfam13426 944547005383 putative active site [active] 944547005384 heme pocket [chemical binding]; other site 944547005385 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547005386 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547005387 dimer interface [polypeptide binding]; other site 944547005388 phosphorylation site [posttranslational modification] 944547005389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547005390 ATP binding site [chemical binding]; other site 944547005391 Mg2+ binding site [ion binding]; other site 944547005392 G-X-G motif; other site 944547005393 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 944547005394 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 944547005395 substrate binding pocket [chemical binding]; other site 944547005396 membrane-bound complex binding site; other site 944547005397 hinge residues; other site 944547005398 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 944547005399 HSP70 interaction site [polypeptide binding]; other site 944547005400 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 944547005401 Peptidase family M50; Region: Peptidase_M50; pfam02163 944547005402 active site 944547005403 putative substrate binding region [chemical binding]; other site 944547005404 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 944547005405 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 944547005406 HlyD family secretion protein; Region: HlyD_3; pfam13437 944547005407 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 944547005408 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 944547005409 HlyD family secretion protein; Region: HlyD_3; pfam13437 944547005410 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 944547005411 VCBS repeat; Region: VCBS_repeat; TIGR01965 944547005412 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 944547005413 Cadherin repeat-like domain; Region: CA_like; cl15786 944547005414 Cadherin repeat-like domain; Region: CA_like; cl15786 944547005415 Ca2+ binding site [ion binding]; other site 944547005416 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 944547005417 Cadherin repeat-like domain; Region: CA_like; cl15786 944547005418 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 944547005419 VCBS repeat; Region: VCBS_repeat; TIGR01965 944547005420 VCBS repeat; Region: VCBS_repeat; TIGR01965 944547005421 VCBS repeat; Region: VCBS_repeat; TIGR01965 944547005422 VCBS repeat; Region: VCBS_repeat; TIGR01965 944547005423 VCBS repeat; Region: VCBS_repeat; TIGR01965 944547005424 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 944547005425 HlyD family secretion protein; Region: HlyD_3; pfam13437 944547005426 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 944547005427 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547005428 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547005429 active site 944547005430 phosphorylation site [posttranslational modification] 944547005431 intermolecular recognition site; other site 944547005432 dimerization interface [polypeptide binding]; other site 944547005433 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 944547005434 DNA binding site [nucleotide binding] 944547005435 NMT1/THI5 like; Region: NMT1; pfam09084 944547005436 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 944547005437 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 944547005438 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 944547005439 substrate binding pocket [chemical binding]; other site 944547005440 membrane-bound complex binding site; other site 944547005441 hinge residues; other site 944547005442 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 944547005443 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 944547005444 substrate binding pocket [chemical binding]; other site 944547005445 membrane-bound complex binding site; other site 944547005446 hinge residues; other site 944547005447 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547005448 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 944547005449 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 944547005450 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 944547005451 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 944547005452 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 944547005453 active site 944547005454 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 944547005455 indole-3-acetamide amidohydrolase; Region: PLN02722 944547005456 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 944547005457 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 944547005458 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 944547005459 alphaNTD homodimer interface [polypeptide binding]; other site 944547005460 alphaNTD - beta interaction site [polypeptide binding]; other site 944547005461 alphaNTD - beta' interaction site [polypeptide binding]; other site 944547005462 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 944547005463 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 944547005464 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 944547005465 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 944547005466 RNA binding surface [nucleotide binding]; other site 944547005467 30S ribosomal protein S11; Validated; Region: PRK05309 944547005468 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 944547005469 30S ribosomal protein S13; Region: bact_S13; TIGR03631 944547005470 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 944547005471 HIT family signature motif; other site 944547005472 catalytic residue [active] 944547005473 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 944547005474 tartrate dehydrogenase; Region: TTC; TIGR02089 944547005475 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 944547005476 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 944547005477 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 944547005478 substrate binding site [chemical binding]; other site 944547005479 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 944547005480 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 944547005481 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 944547005482 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 944547005483 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 944547005484 DNA binding residues [nucleotide binding] 944547005485 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 944547005486 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 944547005487 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 944547005488 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 944547005489 inhibitor-cofactor binding pocket; inhibition site 944547005490 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944547005491 catalytic residue [active] 944547005492 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 944547005493 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 944547005494 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 944547005495 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 944547005496 RNA binding surface [nucleotide binding]; other site 944547005497 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 944547005498 active site 944547005499 Fibronectin type 3 domain; Region: FN3; smart00060 944547005500 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 944547005501 Interdomain contacts; other site 944547005502 Cytokine receptor motif; other site 944547005503 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 944547005504 Interdomain contacts; other site 944547005505 Cytokine receptor motif; other site 944547005506 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 944547005507 Interdomain contacts; other site 944547005508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944547005509 S-adenosylmethionine binding site [chemical binding]; other site 944547005510 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 944547005511 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 944547005512 Walker A/P-loop; other site 944547005513 ATP binding site [chemical binding]; other site 944547005514 Q-loop/lid; other site 944547005515 ABC transporter signature motif; other site 944547005516 Walker B; other site 944547005517 D-loop; other site 944547005518 H-loop/switch region; other site 944547005519 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 944547005520 Peptidase family M23; Region: Peptidase_M23; pfam01551 944547005521 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 944547005522 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 944547005523 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 944547005524 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 944547005525 ABC transporter; Region: ABC_tran_2; pfam12848 944547005526 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 944547005527 Tetrahydrodipicolinate N-succinyltransferase [Amino acid transport and metabolism]; Region: DapD; COG2171 944547005528 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 944547005529 putative trimer interface [polypeptide binding]; other site 944547005530 putative CoA binding site [chemical binding]; other site 944547005531 primosome assembly protein PriA; Validated; Region: PRK05580 944547005532 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 944547005533 ATP binding site [chemical binding]; other site 944547005534 putative Mg++ binding site [ion binding]; other site 944547005535 helicase superfamily c-terminal domain; Region: HELICc; smart00490 944547005536 ATP-binding site [chemical binding]; other site 944547005537 tellurium resistance terB-like protein; Region: terB_like; cl11965 944547005538 metal binding site [ion binding]; metal-binding site 944547005539 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547005540 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547005541 metal binding site [ion binding]; metal-binding site 944547005542 active site 944547005543 I-site; other site 944547005544 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 944547005545 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 944547005546 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 944547005547 dimerization interface [polypeptide binding]; other site 944547005548 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 944547005549 ATP binding site [chemical binding]; other site 944547005550 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 944547005551 homodimer interface [polypeptide binding]; other site 944547005552 chemical substrate binding site [chemical binding]; other site 944547005553 oligomer interface [polypeptide binding]; other site 944547005554 metal binding site [ion binding]; metal-binding site 944547005555 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 944547005556 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 944547005557 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypC; COG0298 944547005558 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 944547005559 G1 box; other site 944547005560 GTP/Mg2+ binding site [chemical binding]; other site 944547005561 G2 box; other site 944547005562 Switch I region; other site 944547005563 G3 box; other site 944547005564 Switch II region; other site 944547005565 G4 box; other site 944547005566 G5 box; other site 944547005567 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 944547005568 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 944547005569 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944547005570 dimer interface [polypeptide binding]; other site 944547005571 putative CheW interface [polypeptide binding]; other site 944547005572 Uncharacterized conserved protein [Function unknown]; Region: COG1284 944547005573 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 944547005574 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 944547005575 flavoprotein, HI0933 family; Region: TIGR00275 944547005576 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 944547005577 allophanate hydrolase; Provisional; Region: PRK08186 944547005578 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 944547005579 Amidase; Region: Amidase; cl11426 944547005580 urea carboxylase; Region: urea_carbox; TIGR02712 944547005581 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 944547005582 ATP-grasp domain; Region: ATP-grasp_4; cl17255 944547005583 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 944547005584 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 944547005585 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 944547005586 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 944547005587 carboxyltransferase (CT) interaction site; other site 944547005588 biotinylation site [posttranslational modification]; other site 944547005589 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 944547005590 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 944547005591 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 944547005592 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 944547005593 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 944547005594 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 944547005595 Walker A/P-loop; other site 944547005596 ATP binding site [chemical binding]; other site 944547005597 Q-loop/lid; other site 944547005598 ABC transporter signature motif; other site 944547005599 Walker B; other site 944547005600 D-loop; other site 944547005601 H-loop/switch region; other site 944547005602 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 944547005603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 944547005604 dimer interface [polypeptide binding]; other site 944547005605 conserved gate region; other site 944547005606 putative PBP binding loops; other site 944547005607 ABC-ATPase subunit interface; other site 944547005608 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 944547005609 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 944547005610 Protein of unknown function (DUF808); Region: DUF808; cl01002 944547005611 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 944547005612 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 944547005613 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 944547005614 FeS/SAM binding site; other site 944547005615 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 944547005616 integral membrane protein; Region: integ_memb_HG; TIGR03954 944547005617 Protein of unknown function (DUF3465); Region: DUF3465; pfam11948 944547005618 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 944547005619 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 944547005620 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 944547005621 Ligand Binding Site [chemical binding]; other site 944547005622 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 944547005623 active site residue [active] 944547005624 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 944547005625 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 944547005626 TrkA-C domain; Region: TrkA_C; pfam02080 944547005627 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 944547005628 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 944547005629 FOG: CBS domain [General function prediction only]; Region: COG0517 944547005630 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 944547005631 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 944547005632 Ligand Binding Site [chemical binding]; other site 944547005633 Protein of unknown function (DUF3010); Region: DUF3010; pfam11215 944547005634 Acylphosphatase; Region: Acylphosphatase; pfam00708 944547005635 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 944547005636 HypF finger; Region: zf-HYPF; pfam07503 944547005637 HypF finger; Region: zf-HYPF; pfam07503 944547005638 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 944547005639 DNA topoisomerase VI subunit B; Provisional; Region: PRK14867 944547005640 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 944547005641 non-specific DNA binding site [nucleotide binding]; other site 944547005642 salt bridge; other site 944547005643 sequence-specific DNA binding site [nucleotide binding]; other site 944547005644 Predicted transcriptional regulator [Transcription]; Region: COG2932 944547005645 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 944547005646 Catalytic site [active] 944547005647 Integrase core domain; Region: rve; pfam00665 944547005648 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 944547005649 AAA domain; Region: AAA_22; pfam13401 944547005650 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 944547005651 Walker A motif; other site 944547005652 ATP binding site [chemical binding]; other site 944547005653 Walker B motif; other site 944547005654 Protein of unknown function (DUF3164); Region: DUF3164; pfam11363 944547005655 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 944547005656 active site 944547005657 metal binding site [ion binding]; metal-binding site 944547005658 AAA domain; Region: AAA_25; pfam13481 944547005659 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 944547005660 Walker A motif; other site 944547005661 ATP binding site [chemical binding]; other site 944547005662 Walker B motif; other site 944547005663 Protein of unknown function (DUF1018); Region: DUF1018; cl01815 944547005664 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 944547005665 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 944547005666 Protein of unknown function (DUF935); Region: DUF935; pfam06074 944547005667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 944547005668 Protein of unknown function (DUF1804); Region: DUF1804; pfam08822 944547005669 Protein of unknown function (DUF1320); Region: DUF1320; cl01818 944547005670 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 944547005671 Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123 944547005672 Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123 944547005673 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 944547005674 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 944547005675 Baseplate J-like protein; Region: Baseplate_J; cl01294 944547005676 Baseplate J-like protein; Region: Baseplate_J; cl01294 944547005677 Baseplate J-like protein; Region: Baseplate_J; pfam04865 944547005678 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684 944547005679 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 944547005680 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 944547005681 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 944547005682 Phage tail tube protein FII; Region: Phage_tube; cl01390 944547005683 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 944547005684 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 944547005685 Phage P2 GpU; Region: Phage_P2_GpU; cl01391 944547005686 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 944547005687 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 944547005688 Predicted transcriptional regulator [Transcription]; Region: COG2932 944547005689 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 944547005690 Catalytic site [active] 944547005691 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 944547005692 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 944547005693 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 944547005694 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 944547005695 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 944547005696 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 944547005697 CRISPR-associated protein Cas5, subtype I-B/TNEAP; Region: cas_Cas5t; TIGR01895 944547005698 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 944547005699 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 944547005700 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 944547005701 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909 944547005702 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 944547005703 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 944547005704 diiron binding motif [ion binding]; other site 944547005705 CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431 944547005706 Secretin and TonB N terminus short domain; Region: STN; smart00965 944547005707 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 944547005708 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 944547005709 N-terminal plug; other site 944547005710 ligand-binding site [chemical binding]; other site 944547005711 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 944547005712 FecR protein; Region: FecR; pfam04773 944547005713 RNA polymerase sigma factor; Reviewed; Region: PRK12527 944547005714 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 944547005715 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 944547005716 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 944547005717 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 944547005718 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 944547005719 putative substrate-binding site; other site 944547005720 nickel binding site [ion binding]; other site 944547005721 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 944547005722 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 944547005723 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 944547005724 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 944547005725 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 944547005726 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 944547005727 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 944547005728 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 944547005729 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 944547005730 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 944547005731 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 944547005732 substrate binding site [chemical binding]; other site 944547005733 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 944547005734 substrate binding site [chemical binding]; other site 944547005735 ligand binding site [chemical binding]; other site 944547005736 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 944547005737 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547005738 PAS fold; Region: PAS; pfam00989 944547005739 putative active site [active] 944547005740 heme pocket [chemical binding]; other site 944547005741 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 944547005742 active site 944547005743 catalytic residues [active] 944547005744 metal binding site [ion binding]; metal-binding site 944547005745 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 944547005746 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 944547005747 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 944547005748 acyl-activating enzyme (AAE) consensus motif; other site 944547005749 putative AMP binding site [chemical binding]; other site 944547005750 putative active site [active] 944547005751 putative CoA binding site [chemical binding]; other site 944547005752 acetyl-CoA acetyltransferase; Provisional; Region: PRK08170 944547005753 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 944547005754 dimer interface [polypeptide binding]; other site 944547005755 active site 944547005756 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 944547005757 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 944547005758 substrate binding site [chemical binding]; other site 944547005759 oxyanion hole (OAH) forming residues; other site 944547005760 trimer interface [polypeptide binding]; other site 944547005761 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 944547005762 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 944547005763 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 944547005764 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 944547005765 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 944547005766 active site 944547005767 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 944547005768 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 944547005769 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 944547005770 putative acyl-acceptor binding pocket; other site 944547005771 Esterase/lipase [General function prediction only]; Region: COG1647 944547005772 PAS domain; Region: PAS_9; pfam13426 944547005773 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 944547005774 putative active site [active] 944547005775 heme pocket [chemical binding]; other site 944547005776 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547005777 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547005778 metal binding site [ion binding]; metal-binding site 944547005779 active site 944547005780 I-site; other site 944547005781 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 944547005782 Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154 944547005783 Rab subfamily motif 1 (RabSF1); other site 944547005784 G1 box; other site 944547005785 GTP/Mg2+ binding site [chemical binding]; other site 944547005786 Rab subfamily motif 2 (RabSF2); other site 944547005787 Switch I region; other site 944547005788 G2 box; other site 944547005789 effector interaction site; other site 944547005790 GDI interaction site; other site 944547005791 Rab family motif 1 (RabF1); other site 944547005792 GEF interaction site [polypeptide binding]; other site 944547005793 Rab family motif 2 (RabF2); other site 944547005794 G3 box; other site 944547005795 Switch II region; other site 944547005796 Rab family motif 3 (RabF3); other site 944547005797 Rab family motif 4 (RabF4); other site 944547005798 Rab family motif 5 (RabF5); other site 944547005799 Rab subfamily motif 3 (RabSF3); other site 944547005800 G4 box; other site 944547005801 G5 box; other site 944547005802 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 944547005803 ligand binding site [chemical binding]; other site 944547005804 hypothetical protein; Provisional; Region: PRK12378 944547005805 VacJ like lipoprotein; Region: VacJ; cl01073 944547005806 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 944547005807 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 944547005808 Protein export membrane protein; Region: SecD_SecF; cl14618 944547005809 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 944547005810 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 944547005811 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 944547005812 motif II; other site 944547005813 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 944547005814 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 944547005815 catalytic residues [active] 944547005816 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 944547005817 catalytic residues [active] 944547005818 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 944547005819 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944547005820 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 944547005821 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 944547005822 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 944547005823 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 944547005824 active site 944547005825 BCCT family transporter; Region: BCCT; pfam02028 944547005826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 944547005827 putative substrate translocation pore; other site 944547005828 Uncharacterized ACR, YagE family COG1723; Region: DUF155; pfam02582 944547005829 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 944547005830 substrate binding site [chemical binding]; other site 944547005831 helicase-primase primase subunit; Provisional; Region: PHA03119 944547005832 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 944547005833 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 944547005834 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 944547005835 TrkA-N domain; Region: TrkA_N; pfam02254 944547005836 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 944547005837 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 944547005838 dimer interface [polypeptide binding]; other site 944547005839 active site 944547005840 glycine-pyridoxal phosphate binding site [chemical binding]; other site 944547005841 folate binding site [chemical binding]; other site 944547005842 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 944547005843 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 944547005844 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 944547005845 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 944547005846 DNA binding site [nucleotide binding] 944547005847 active site 944547005848 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 944547005849 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 944547005850 binding surface 944547005851 TPR motif; other site 944547005852 Tetratricopeptide repeat; Region: TPR_16; pfam13432 944547005853 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 944547005854 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 944547005855 binding surface 944547005856 TPR motif; other site 944547005857 Tetratricopeptide repeat; Region: TPR_16; pfam13432 944547005858 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 944547005859 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 944547005860 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 944547005861 dimer interface [polypeptide binding]; other site 944547005862 active site 944547005863 glycine-pyridoxal phosphate binding site [chemical binding]; other site 944547005864 folate binding site [chemical binding]; other site 944547005865 acetylornithine aminotransferase; Provisional; Region: PRK02627 944547005866 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 944547005867 inhibitor-cofactor binding pocket; inhibition site 944547005868 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944547005869 catalytic residue [active] 944547005870 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 944547005871 MOSC domain; Region: MOSC; pfam03473 944547005872 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 944547005873 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 944547005874 ligand binding site [chemical binding]; other site 944547005875 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 944547005876 active site 944547005877 catalytic residues [active] 944547005878 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 944547005879 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 944547005880 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 944547005881 ATP binding site [chemical binding]; other site 944547005882 Mg++ binding site [ion binding]; other site 944547005883 motif III; other site 944547005884 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 944547005885 nucleotide binding region [chemical binding]; other site 944547005886 ATP-binding site [chemical binding]; other site 944547005887 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 944547005888 ABC transporter signature motif; other site 944547005889 Walker B; other site 944547005890 D-loop; other site 944547005891 H-loop/switch region; other site 944547005892 HipA N-terminal domain; Region: Couple_hipA; pfam13657 944547005893 HipA-like N-terminal domain; Region: HipA_N; pfam07805 944547005894 HipA-like C-terminal domain; Region: HipA_C; pfam07804 944547005895 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 944547005896 non-specific DNA binding site [nucleotide binding]; other site 944547005897 salt bridge; other site 944547005898 sequence-specific DNA binding site [nucleotide binding]; other site 944547005899 uncharacterized domain; Region: TIGR00702 944547005900 YcaO-like family; Region: YcaO; pfam02624 944547005901 Domain of unknown function DUF302; Region: DUF302; cl01364 944547005902 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 944547005903 Nitrate and nitrite sensing; Region: NIT; pfam08376 944547005904 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944547005905 dimer interface [polypeptide binding]; other site 944547005906 putative CheW interface [polypeptide binding]; other site 944547005907 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 944547005908 RNA/DNA hybrid binding site [nucleotide binding]; other site 944547005909 active site 944547005910 4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944 944547005911 active site 944547005912 catalytic residues [active] 944547005913 metal binding site [ion binding]; metal-binding site 944547005914 putative monooxygenase; Provisional; Region: PRK11118 944547005915 Protein of unknown function, DUF417; Region: DUF417; cl01162 944547005916 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 944547005917 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 944547005918 active site 944547005919 DNA binding site [nucleotide binding] 944547005920 Cytochrome c; Region: Cytochrom_C; cl11414 944547005921 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 944547005922 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 944547005923 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 944547005924 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 944547005925 Part of AAA domain; Region: AAA_19; pfam13245 944547005926 Family description; Region: UvrD_C_2; pfam13538 944547005927 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 944547005928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547005929 active site 944547005930 phosphorylation site [posttranslational modification] 944547005931 intermolecular recognition site; other site 944547005932 dimerization interface [polypeptide binding]; other site 944547005933 PAS domain; Region: PAS_9; pfam13426 944547005934 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547005935 putative active site [active] 944547005936 heme pocket [chemical binding]; other site 944547005937 Response regulator receiver domain; Region: Response_reg; pfam00072 944547005938 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547005939 active site 944547005940 phosphorylation site [posttranslational modification] 944547005941 intermolecular recognition site; other site 944547005942 dimerization interface [polypeptide binding]; other site 944547005943 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 944547005944 dimer interface [polypeptide binding]; other site 944547005945 phosphorylation site [posttranslational modification] 944547005946 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547005947 ATP binding site [chemical binding]; other site 944547005948 Mg2+ binding site [ion binding]; other site 944547005949 G-X-G motif; other site 944547005950 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547005951 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 944547005952 phosphorylation site [posttranslational modification] 944547005953 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547005954 ATP binding site [chemical binding]; other site 944547005955 Mg2+ binding site [ion binding]; other site 944547005956 G-X-G motif; other site 944547005957 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 944547005958 active site 944547005959 DNA binding site [nucleotide binding] 944547005960 Int/Topo IB signature motif; other site 944547005961 Firmicute plasmid replication protein (RepL); Region: RepL; pfam05732 944547005962 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 944547005963 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 944547005964 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547005965 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547005966 dimer interface [polypeptide binding]; other site 944547005967 phosphorylation site [posttranslational modification] 944547005968 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547005969 ATP binding site [chemical binding]; other site 944547005970 Mg2+ binding site [ion binding]; other site 944547005971 G-X-G motif; other site 944547005972 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 944547005973 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 944547005974 PAS domain; Region: PAS_9; pfam13426 944547005975 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547005976 putative active site [active] 944547005977 heme pocket [chemical binding]; other site 944547005978 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547005979 metal binding site [ion binding]; metal-binding site 944547005980 active site 944547005981 I-site; other site 944547005982 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 944547005983 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 944547005984 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 944547005985 putative active site [active] 944547005986 PhoH-like protein; Region: PhoH; cl17668 944547005987 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 944547005988 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 944547005989 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 944547005990 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 944547005991 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 944547005992 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 944547005993 Nitrate and nitrite sensing; Region: NIT; pfam08376 944547005994 GAF domain; Region: GAF_2; pfam13185 944547005995 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547005996 PAS domain; Region: PAS_9; pfam13426 944547005997 putative active site [active] 944547005998 heme pocket [chemical binding]; other site 944547005999 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547006000 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547006001 metal binding site [ion binding]; metal-binding site 944547006002 active site 944547006003 I-site; other site 944547006004 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 944547006005 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 944547006006 ATP binding site [chemical binding]; other site 944547006007 Mg++ binding site [ion binding]; other site 944547006008 motif III; other site 944547006009 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 944547006010 nucleotide binding region [chemical binding]; other site 944547006011 ATP-binding site [chemical binding]; other site 944547006012 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 944547006013 putative RNA binding site [nucleotide binding]; other site 944547006014 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 944547006015 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 944547006016 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 944547006017 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 944547006018 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 944547006019 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 944547006020 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 944547006021 putative active site [active] 944547006022 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 944547006023 DctM-like transporters; Region: DctM; pfam06808 944547006024 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 944547006025 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 944547006026 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 944547006027 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547006028 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547006029 active site 944547006030 phosphorylation site [posttranslational modification] 944547006031 intermolecular recognition site; other site 944547006032 dimerization interface [polypeptide binding]; other site 944547006033 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 944547006034 DNA binding site [nucleotide binding] 944547006035 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 944547006036 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547006037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547006038 ATP binding site [chemical binding]; other site 944547006039 Mg2+ binding site [ion binding]; other site 944547006040 G-X-G motif; other site 944547006041 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 944547006042 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 944547006043 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 944547006044 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 944547006045 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 944547006046 Walker A/P-loop; other site 944547006047 ATP binding site [chemical binding]; other site 944547006048 Q-loop/lid; other site 944547006049 ABC transporter signature motif; other site 944547006050 Walker B; other site 944547006051 D-loop; other site 944547006052 H-loop/switch region; other site 944547006053 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 944547006054 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 944547006055 Walker A/P-loop; other site 944547006056 ATP binding site [chemical binding]; other site 944547006057 Q-loop/lid; other site 944547006058 ABC transporter signature motif; other site 944547006059 Walker B; other site 944547006060 D-loop; other site 944547006061 H-loop/switch region; other site 944547006062 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 944547006063 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 944547006064 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 944547006065 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 944547006066 HlyD family secretion protein; Region: HlyD_3; pfam13437 944547006067 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 944547006068 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 944547006069 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 944547006070 Domain of unknown function (DUF947); Region: DUF947; pfam06102 944547006071 heat shock protein 90; Provisional; Region: PRK05218 944547006072 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547006073 ATP binding site [chemical binding]; other site 944547006074 Mg2+ binding site [ion binding]; other site 944547006075 G-X-G motif; other site 944547006076 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 944547006077 amphipathic channel; other site 944547006078 Asn-Pro-Ala signature motifs; other site 944547006079 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 944547006080 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 944547006081 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 944547006082 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 944547006083 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 944547006084 tetramer interface [polypeptide binding]; other site 944547006085 heme binding pocket [chemical binding]; other site 944547006086 NADPH binding site [chemical binding]; other site 944547006087 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 944547006088 mce related protein; Region: MCE; pfam02470 944547006089 mce related protein; Region: MCE; pfam02470 944547006090 mce related protein; Region: MCE; pfam02470 944547006091 mce related protein; Region: MCE; pfam02470 944547006092 mce related protein; Region: MCE; pfam02470 944547006093 Paraquat-inducible protein A; Region: PqiA; pfam04403 944547006094 Paraquat-inducible protein A; Region: PqiA; pfam04403 944547006095 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 944547006096 heme-binding site [chemical binding]; other site 944547006097 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547006098 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547006099 metal binding site [ion binding]; metal-binding site 944547006100 active site 944547006101 I-site; other site 944547006102 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 944547006103 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 944547006104 NADPH bind site [chemical binding]; other site 944547006105 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 944547006106 putative FMN binding site [chemical binding]; other site 944547006107 NADPH bind site [chemical binding]; other site 944547006108 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 944547006109 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 944547006110 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 944547006111 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 944547006112 putative deacylase active site [active] 944547006113 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 944547006114 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 944547006115 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944547006116 S-adenosylmethionine binding site [chemical binding]; other site 944547006117 Secretin and TonB N terminus short domain; Region: STN; pfam07660 944547006118 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 944547006119 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 944547006120 N-terminal plug; other site 944547006121 ligand-binding site [chemical binding]; other site 944547006122 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 944547006123 FecR protein; Region: FecR; pfam04773 944547006124 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 944547006125 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 944547006126 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 944547006127 DNA binding residues [nucleotide binding] 944547006128 agmatinase; Region: agmatinase; TIGR01230 944547006129 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 944547006130 putative active site [active] 944547006131 Mn binding site [ion binding]; other site 944547006132 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 944547006133 isopropylmalate/citramalate/homocitrate synthases; Region: LEU1_arch; TIGR02090 944547006134 active site 944547006135 catalytic residues [active] 944547006136 metal binding site [ion binding]; metal-binding site 944547006137 Helix-turn-helix domain; Region: HTH_18; pfam12833 944547006138 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 944547006139 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 944547006140 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 944547006141 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 944547006142 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 944547006143 DHHA2 domain; Region: DHHA2; pfam02833 944547006144 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 944547006145 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 944547006146 active site 944547006147 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 944547006148 Aspartase; Region: Aspartase; cd01357 944547006149 active sites [active] 944547006150 tetramer interface [polypeptide binding]; other site 944547006151 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547006152 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547006153 active site 944547006154 phosphorylation site [posttranslational modification] 944547006155 intermolecular recognition site; other site 944547006156 dimerization interface [polypeptide binding]; other site 944547006157 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 944547006158 DNA binding site [nucleotide binding] 944547006159 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547006160 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547006161 ATP binding site [chemical binding]; other site 944547006162 Mg2+ binding site [ion binding]; other site 944547006163 G-X-G motif; other site 944547006164 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 944547006165 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 944547006166 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 944547006167 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 944547006168 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 944547006169 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 944547006170 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 944547006171 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 944547006172 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 944547006173 TPR motif; other site 944547006174 binding surface 944547006175 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 944547006176 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 944547006177 ligand binding site [chemical binding]; other site 944547006178 Ferritin-like domain; Region: Ferritin; pfam00210 944547006179 DPS-like protein, ferritin-like diiron-binding domain; Region: DPSL; cd01052 944547006180 diiron binding motif [ion binding]; other site 944547006181 translocation protein TolB; Provisional; Region: tolB; PRK04043 944547006182 TonB C terminal; Region: TonB_2; pfam13103 944547006183 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 944547006184 TolR protein; Region: tolR; TIGR02801 944547006185 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 944547006186 ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216 944547006187 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 944547006188 gamma subunit interface [polypeptide binding]; other site 944547006189 epsilon subunit interface [polypeptide binding]; other site 944547006190 LBP interface [polypeptide binding]; other site 944547006191 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 944547006192 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 944547006193 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 944547006194 alpha subunit interaction interface [polypeptide binding]; other site 944547006195 Walker A motif; other site 944547006196 ATP binding site [chemical binding]; other site 944547006197 Walker B motif; other site 944547006198 inhibitor binding site; inhibition site 944547006199 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 944547006200 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 944547006201 core domain interface [polypeptide binding]; other site 944547006202 delta subunit interface [polypeptide binding]; other site 944547006203 epsilon subunit interface [polypeptide binding]; other site 944547006204 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 944547006205 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 944547006206 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 944547006207 beta subunit interaction interface [polypeptide binding]; other site 944547006208 Walker A motif; other site 944547006209 ATP binding site [chemical binding]; other site 944547006210 Walker B motif; other site 944547006211 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 944547006212 F0F1 ATP synthase subunit delta; Validated; Region: PRK08474 944547006213 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 944547006214 F0F1 ATP synthase subunit B; Validated; Region: PRK08475 944547006215 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 944547006216 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 944547006217 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 944547006218 ParB-like nuclease domain; Region: ParB; smart00470 944547006219 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 944547006220 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 944547006221 P-loop; other site 944547006222 Magnesium ion binding site [ion binding]; other site 944547006223 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 944547006224 Magnesium ion binding site [ion binding]; other site 944547006225 biotin--protein ligase; Provisional; Region: PRK08477 944547006226 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 944547006227 Membrane transport protein; Region: Mem_trans; cl09117 944547006228 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 944547006229 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 944547006230 putative active site [active] 944547006231 substrate binding site [chemical binding]; other site 944547006232 putative cosubstrate binding site; other site 944547006233 catalytic site [active] 944547006234 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 944547006235 substrate binding site [chemical binding]; other site 944547006236 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 944547006237 nucleotide binding site [chemical binding]; other site 944547006238 homotetrameric interface [polypeptide binding]; other site 944547006239 putative phosphate binding site [ion binding]; other site 944547006240 putative allosteric binding site; other site 944547006241 GTPase CgtA; Reviewed; Region: obgE; PRK12299 944547006242 GTP1/OBG; Region: GTP1_OBG; pfam01018 944547006243 Obg GTPase; Region: Obg; cd01898 944547006244 G1 box; other site 944547006245 GTP/Mg2+ binding site [chemical binding]; other site 944547006246 Switch I region; other site 944547006247 G2 box; other site 944547006248 G3 box; other site 944547006249 Switch II region; other site 944547006250 G4 box; other site 944547006251 G5 box; other site 944547006252 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 944547006253 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 944547006254 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 944547006255 homotrimer interaction site [polypeptide binding]; other site 944547006256 putative active site [active] 944547006257 DNA primase, catalytic core; Region: dnaG; TIGR01391 944547006258 CHC2 zinc finger; Region: zf-CHC2; pfam01807 944547006259 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 944547006260 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 944547006261 active site 944547006262 metal binding site [ion binding]; metal-binding site 944547006263 interdomain interaction site; other site 944547006264 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 944547006265 binding surface 944547006266 TPR motif; other site 944547006267 ribonuclease III; Reviewed; Region: rnc; PRK00102 944547006268 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 944547006269 dimerization interface [polypeptide binding]; other site 944547006270 active site 944547006271 metal binding site [ion binding]; metal-binding site 944547006272 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 944547006273 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 944547006274 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 944547006275 Tetramer interface [polypeptide binding]; other site 944547006276 active site 944547006277 FMN-binding site [chemical binding]; other site 944547006278 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 944547006279 M48 family peptidase; Provisional; Region: PRK03001 944547006280 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 944547006281 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 944547006282 catalytic core [active] 944547006283 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 944547006284 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 944547006285 trmE is a tRNA modification GTPase; Region: trmE; cd04164 944547006286 G1 box; other site 944547006287 GTP/Mg2+ binding site [chemical binding]; other site 944547006288 Switch I region; other site 944547006289 G2 box; other site 944547006290 Switch II region; other site 944547006291 G3 box; other site 944547006292 G4 box; other site 944547006293 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 944547006294 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 944547006295 membrane protein insertase; Provisional; Region: PRK01318 944547006296 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 944547006297 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 944547006298 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 944547006299 Clp amino terminal domain; Region: Clp_N; pfam02861 944547006300 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 944547006301 Walker A motif; other site 944547006302 ATP binding site [chemical binding]; other site 944547006303 Walker B motif; other site 944547006304 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 944547006305 Walker A motif; other site 944547006306 ATP binding site [chemical binding]; other site 944547006307 Walker B motif; other site 944547006308 arginine finger; other site 944547006309 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 944547006310 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 944547006311 PAS domain; Region: PAS; smart00091 944547006312 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547006313 dimer interface [polypeptide binding]; other site 944547006314 phosphorylation site [posttranslational modification] 944547006315 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547006316 ATP binding site [chemical binding]; other site 944547006317 Mg2+ binding site [ion binding]; other site 944547006318 G-X-G motif; other site 944547006319 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 944547006320 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 944547006321 ligand binding site [chemical binding]; other site 944547006322 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 944547006323 RNA/DNA hybrid binding site [nucleotide binding]; other site 944547006324 active site 944547006325 Domain of unknown function DUF77; Region: DUF77; pfam01910 944547006326 methionine sulfoxide reductase A; Provisional; Region: PRK14054 944547006327 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 944547006328 heme-binding site [chemical binding]; other site 944547006329 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 944547006330 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 944547006331 putative metal binding site [ion binding]; other site 944547006332 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 944547006333 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 944547006334 ABC-ATPase subunit interface; other site 944547006335 dimer interface [polypeptide binding]; other site 944547006336 putative PBP binding regions; other site 944547006337 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 944547006338 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 944547006339 Walker A/P-loop; other site 944547006340 ATP binding site [chemical binding]; other site 944547006341 Q-loop/lid; other site 944547006342 ABC transporter signature motif; other site 944547006343 Walker B; other site 944547006344 D-loop; other site 944547006345 H-loop/switch region; other site 944547006346 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 944547006347 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 944547006348 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 944547006349 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 944547006350 intersubunit interface [polypeptide binding]; other site 944547006351 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 944547006352 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 944547006353 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 944547006354 N-terminal plug; other site 944547006355 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 944547006356 ligand-binding site [chemical binding]; other site 944547006357 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 944547006358 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 944547006359 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 944547006360 intersubunit interface [polypeptide binding]; other site 944547006361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944547006362 Methyltransferase domain; Region: Methyltransf_31; pfam13847 944547006363 S-adenosylmethionine binding site [chemical binding]; other site 944547006364 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 944547006365 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 944547006366 tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805 944547006367 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 944547006368 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 944547006369 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 944547006370 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 944547006371 DNA-binding site [nucleotide binding]; DNA binding site 944547006372 RNA-binding motif; other site 944547006373 methionine sulfoxide reductase B; Provisional; Region: PRK05508 944547006374 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 944547006375 Response regulator receiver domain; Region: Response_reg; pfam00072 944547006376 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547006377 active site 944547006378 phosphorylation site [posttranslational modification] 944547006379 intermolecular recognition site; other site 944547006380 dimerization interface [polypeptide binding]; other site 944547006381 Response regulator receiver domain; Region: Response_reg; pfam00072 944547006382 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547006383 active site 944547006384 phosphorylation site [posttranslational modification] 944547006385 intermolecular recognition site; other site 944547006386 dimerization interface [polypeptide binding]; other site 944547006387 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 944547006388 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 944547006389 substrate binding pocket [chemical binding]; other site 944547006390 membrane-bound complex binding site; other site 944547006391 hinge residues; other site 944547006392 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 944547006393 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 944547006394 substrate binding pocket [chemical binding]; other site 944547006395 membrane-bound complex binding site; other site 944547006396 hinge residues; other site 944547006397 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547006398 dimer interface [polypeptide binding]; other site 944547006399 phosphorylation site [posttranslational modification] 944547006400 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547006401 ATP binding site [chemical binding]; other site 944547006402 Mg2+ binding site [ion binding]; other site 944547006403 G-X-G motif; other site 944547006404 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 944547006405 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547006406 active site 944547006407 phosphorylation site [posttranslational modification] 944547006408 intermolecular recognition site; other site 944547006409 dimerization interface [polypeptide binding]; other site 944547006410 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 944547006411 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 944547006412 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 944547006413 DsrE/DsrF-like family; Region: DrsE; cl00672 944547006414 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 944547006415 putative active site [active] 944547006416 putative CoA binding site [chemical binding]; other site 944547006417 nudix motif; other site 944547006418 metal binding site [ion binding]; metal-binding site 944547006419 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 944547006420 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 944547006421 inhibitor-cofactor binding pocket; inhibition site 944547006422 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944547006423 catalytic residue [active] 944547006424 NMT1/THI5 like; Region: NMT1; pfam09084 944547006425 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 944547006426 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 944547006427 substrate binding pocket [chemical binding]; other site 944547006428 membrane-bound complex binding site; other site 944547006429 hinge residues; other site 944547006430 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547006431 dimer interface [polypeptide binding]; other site 944547006432 phosphorylation site [posttranslational modification] 944547006433 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547006434 ATP binding site [chemical binding]; other site 944547006435 Mg2+ binding site [ion binding]; other site 944547006436 G-X-G motif; other site 944547006437 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 944547006438 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 944547006439 purine monophosphate binding site [chemical binding]; other site 944547006440 dimer interface [polypeptide binding]; other site 944547006441 putative catalytic residues [active] 944547006442 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 944547006443 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 944547006444 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547006445 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547006446 metal binding site [ion binding]; metal-binding site 944547006447 active site 944547006448 I-site; other site 944547006449 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 944547006450 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 944547006451 dimerization interface [polypeptide binding]; other site 944547006452 ATP binding site [chemical binding]; other site 944547006453 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 944547006454 dimerization interface [polypeptide binding]; other site 944547006455 ATP binding site [chemical binding]; other site 944547006456 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 944547006457 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 944547006458 Peptidase family M23; Region: Peptidase_M23; pfam01551 944547006459 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 944547006460 DNA binding residues [nucleotide binding] 944547006461 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 944547006462 Coenzyme A binding pocket [chemical binding]; other site 944547006463 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 944547006464 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 944547006465 inhibitor-cofactor binding pocket; inhibition site 944547006466 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944547006467 catalytic residue [active] 944547006468 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 944547006469 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 944547006470 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 944547006471 GTP cyclohydrolase I; Provisional; Region: PLN03044 944547006472 homodecamer interface [polypeptide binding]; other site 944547006473 active site 944547006474 putative catalytic site residues [active] 944547006475 zinc binding site [ion binding]; other site 944547006476 GTP-CH-I/GFRP interaction surface; other site 944547006477 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 944547006478 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 944547006479 oligomer interface [polypeptide binding]; other site 944547006480 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 944547006481 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 944547006482 Type II/IV secretion system protein; Region: T2SE; pfam00437 944547006483 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 944547006484 Walker A motif; other site 944547006485 ATP binding site [chemical binding]; other site 944547006486 Walker B motif; other site 944547006487 GTPase Era; Reviewed; Region: era; PRK00089 944547006488 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 944547006489 G1 box; other site 944547006490 GTP/Mg2+ binding site [chemical binding]; other site 944547006491 Switch I region; other site 944547006492 G2 box; other site 944547006493 Switch II region; other site 944547006494 G3 box; other site 944547006495 G4 box; other site 944547006496 G5 box; other site 944547006497 KH domain; Region: KH_2; pfam07650 944547006498 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 944547006499 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 944547006500 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 944547006501 Walker A motif; other site 944547006502 ATP binding site [chemical binding]; other site 944547006503 Walker B motif; other site 944547006504 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 944547006505 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 944547006506 active site 944547006507 catalytic residues [active] 944547006508 metal binding site [ion binding]; metal-binding site 944547006509 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 944547006510 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 944547006511 oligomer interface [polypeptide binding]; other site 944547006512 active site residues [active] 944547006513 trigger factor; Provisional; Region: tig; PRK01490 944547006514 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 944547006515 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 944547006516 Aerotolerance regulator N-terminal; Region: BatA; cl06567 944547006517 von Willebrand factor type A domain; Region: VWA_2; pfam13519 944547006518 metal ion-dependent adhesion site (MIDAS); other site 944547006519 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 944547006520 binding surface 944547006521 TPR motif; other site 944547006522 Tetratricopeptide repeat; Region: TPR_16; pfam13432 944547006523 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 944547006524 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 944547006525 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 944547006526 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 944547006527 dimer interface [polypeptide binding]; other site 944547006528 active site 944547006529 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 944547006530 catalytic residues [active] 944547006531 substrate binding site [chemical binding]; other site 944547006532 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 944547006533 Rubredoxin; Region: Rubredoxin; pfam00301 944547006534 iron binding site [ion binding]; other site 944547006535 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 944547006536 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 944547006537 NAD(P) binding pocket [chemical binding]; other site 944547006538 integrase; Provisional; Region: PRK09692 944547006539 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 944547006540 active site 944547006541 Int/Topo IB signature motif; other site 944547006542 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 944547006543 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 944547006544 Protein of unknown function (DUF499); Region: DUF499; pfam04465 944547006545 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 944547006546 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 944547006547 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 944547006548 Catalytic domain of Protein Kinases; Region: PKc; cd00180 944547006549 active site 944547006550 ATP binding site [chemical binding]; other site 944547006551 substrate binding site [chemical binding]; other site 944547006552 activation loop (A-loop); other site 944547006553 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 944547006554 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 944547006555 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 944547006556 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 944547006557 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 944547006558 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 944547006559 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 944547006560 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 944547006561 phosphopeptide binding site; other site 944547006562 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 944547006563 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 944547006564 Walker A motif; other site 944547006565 ATP binding site [chemical binding]; other site 944547006566 Walker B motif; other site 944547006567 arginine finger; other site 944547006568 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 944547006569 Walker A motif; other site 944547006570 ATP binding site [chemical binding]; other site 944547006571 Walker B motif; other site 944547006572 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 944547006573 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 944547006574 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 944547006575 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 944547006576 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 944547006577 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 944547006578 Protein of unknown function (DUF877); Region: DUF877; pfam05943 944547006579 Protein of unknown function (DUF770); Region: DUF770; cl01402 944547006580 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 944547006581 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 944547006582 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 944547006583 Peptidase family M23; Region: Peptidase_M23; pfam01551 944547006584 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 944547006585 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 944547006586 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 944547006587 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 944547006588 Predicted chitinase [General function prediction only]; Region: COG3179 944547006589 catalytic residue [active] 944547006590 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 944547006591 TPR repeat; Region: TPR_11; pfam13414 944547006592 binding surface 944547006593 TPR motif; other site 944547006594 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 944547006595 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 944547006596 Walker A/P-loop; other site 944547006597 ATP binding site [chemical binding]; other site 944547006598 Q-loop/lid; other site 944547006599 ABC transporter signature motif; other site 944547006600 Walker B; other site 944547006601 D-loop; other site 944547006602 H-loop/switch region; other site 944547006603 TOBE domain; Region: TOBE_2; pfam08402 944547006604 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 944547006605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 944547006606 dimer interface [polypeptide binding]; other site 944547006607 conserved gate region; other site 944547006608 putative PBP binding loops; other site 944547006609 ABC-ATPase subunit interface; other site 944547006610 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 944547006611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 944547006612 dimer interface [polypeptide binding]; other site 944547006613 conserved gate region; other site 944547006614 putative PBP binding loops; other site 944547006615 ABC-ATPase subunit interface; other site 944547006616 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 944547006617 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 944547006618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 944547006619 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 944547006620 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 944547006621 homodimer interface [polypeptide binding]; other site 944547006622 substrate-cofactor binding pocket; other site 944547006623 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944547006624 catalytic residue [active] 944547006625 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 944547006626 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 944547006627 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 944547006628 catalytic residue [active] 944547006629 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547006630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547006631 active site 944547006632 phosphorylation site [posttranslational modification] 944547006633 intermolecular recognition site; other site 944547006634 dimerization interface [polypeptide binding]; other site 944547006635 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 944547006636 DNA binding site [nucleotide binding] 944547006637 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944547006638 dimer interface [polypeptide binding]; other site 944547006639 putative CheW interface [polypeptide binding]; other site 944547006640 PAS domain S-box; Region: sensory_box; TIGR00229 944547006641 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547006642 putative active site [active] 944547006643 heme pocket [chemical binding]; other site 944547006644 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547006645 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547006646 metal binding site [ion binding]; metal-binding site 944547006647 active site 944547006648 I-site; other site 944547006649 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 944547006650 NMT1/THI5 like; Region: NMT1; pfam09084 944547006651 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 944547006652 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 944547006653 substrate binding pocket [chemical binding]; other site 944547006654 membrane-bound complex binding site; other site 944547006655 hinge residues; other site 944547006656 PAS domain; Region: PAS_9; pfam13426 944547006657 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547006658 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547006659 ATP binding site [chemical binding]; other site 944547006660 Mg2+ binding site [ion binding]; other site 944547006661 G-X-G motif; other site 944547006662 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 944547006663 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944547006664 dimer interface [polypeptide binding]; other site 944547006665 putative CheW interface [polypeptide binding]; other site 944547006666 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547006667 PAS fold; Region: PAS_3; pfam08447 944547006668 putative active site [active] 944547006669 heme pocket [chemical binding]; other site 944547006670 Membrane transport protein; Region: Mem_trans; cl09117 944547006671 Transcriptional regulator [Transcription]; Region: LysR; COG0583 944547006672 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 944547006673 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 944547006674 dimerization interface [polypeptide binding]; other site 944547006675 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 944547006676 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 944547006677 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 944547006678 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 944547006679 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 944547006680 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 944547006681 Cytochrome c; Region: Cytochrom_C; cl11414 944547006682 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 944547006683 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547006684 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 944547006685 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 944547006686 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 944547006687 Coenzyme A binding pocket [chemical binding]; other site 944547006688 Protein of unknown function (DUF1007); Region: DUF1007; cl01487 944547006689 High-affinity nickel-transport protein; Region: NicO; cl00964 944547006690 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018 944547006691 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 944547006692 putative metal binding residues [ion binding]; other site 944547006693 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 944547006694 metal binding site 2 [ion binding]; metal-binding site 944547006695 putative DNA binding helix; other site 944547006696 metal binding site 1 [ion binding]; metal-binding site 944547006697 dimer interface [polypeptide binding]; other site 944547006698 structural Zn2+ binding site [ion binding]; other site 944547006699 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 944547006700 short chain dehydrogenase; Provisional; Region: PRK12746 944547006701 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 944547006702 NAD(P) binding site [chemical binding]; other site 944547006703 active site 944547006704 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 944547006705 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 944547006706 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 944547006707 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 944547006708 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 944547006709 active site 944547006710 substrate binding pocket [chemical binding]; other site 944547006711 dimer interface [polypeptide binding]; other site 944547006712 SnoaL-like domain; Region: SnoaL_3; pfam13474 944547006713 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 944547006714 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 944547006715 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 944547006716 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 944547006717 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 944547006718 HlyD family secretion protein; Region: HlyD_3; pfam13437 944547006719 Outer membrane efflux protein; Region: OEP; pfam02321 944547006720 Outer membrane efflux protein; Region: OEP; pfam02321 944547006721 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 944547006722 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944547006723 dimer interface [polypeptide binding]; other site 944547006724 putative CheW interface [polypeptide binding]; other site 944547006725 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 944547006726 classical (c) SDRs; Region: SDR_c; cd05233 944547006727 NAD(P) binding site [chemical binding]; other site 944547006728 active site 944547006729 potential frameshift: common BLAST hit: gi|296272585|ref|YP_003655216.1| integral membrane sensor signal transduction histidine kinase 944547006730 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 944547006731 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547006732 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547006733 dimer interface [polypeptide binding]; other site 944547006734 phosphorylation site [posttranslational modification] 944547006735 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547006736 ATP binding site [chemical binding]; other site 944547006737 Mg2+ binding site [ion binding]; other site 944547006738 G-X-G motif; other site 944547006739 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 944547006740 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 944547006741 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 944547006742 Imelysin; Region: Peptidase_M75; pfam09375 944547006743 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 944547006744 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 944547006745 Imelysin; Region: Peptidase_M75; cl09159 944547006746 F0F1 ATP synthase subunit C; Validated; Region: PRK08482 944547006747 Mechanosensitive ion channel; Region: MS_channel; pfam00924 944547006748 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 944547006749 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 944547006750 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 944547006751 putative catalytic cysteine [active] 944547006752 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 944547006753 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 944547006754 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 944547006755 4Fe-4S binding domain; Region: Fer4_5; pfam12801 944547006756 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 944547006757 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 944547006758 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547006759 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 944547006760 dimer interface [polypeptide binding]; other site 944547006761 phosphorylation site [posttranslational modification] 944547006762 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547006763 ATP binding site [chemical binding]; other site 944547006764 Mg2+ binding site [ion binding]; other site 944547006765 G-X-G motif; other site 944547006766 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547006767 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547006768 active site 944547006769 phosphorylation site [posttranslational modification] 944547006770 intermolecular recognition site; other site 944547006771 dimerization interface [polypeptide binding]; other site 944547006772 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 944547006773 DNA binding site [nucleotide binding] 944547006774 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 944547006775 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 944547006776 DNA binding site [nucleotide binding] 944547006777 active site 944547006778 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 944547006779 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 944547006780 active site 944547006781 substrate binding site [chemical binding]; other site 944547006782 metal binding site [ion binding]; metal-binding site 944547006783 Predicted amidohydrolase [General function prediction only]; Region: COG0388 944547006784 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 944547006785 active site 944547006786 catalytic triad [active] 944547006787 dimer interface [polypeptide binding]; other site 944547006788 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 944547006789 flavodoxin FldA; Validated; Region: PRK09267 944547006790 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 944547006791 metal binding site 2 [ion binding]; metal-binding site 944547006792 putative DNA binding helix; other site 944547006793 metal binding site 1 [ion binding]; metal-binding site 944547006794 dimer interface [polypeptide binding]; other site 944547006795 structural Zn2+ binding site [ion binding]; other site 944547006796 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 944547006797 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 944547006798 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 944547006799 G1 box; other site 944547006800 GTP/Mg2+ binding site [chemical binding]; other site 944547006801 Switch I region; other site 944547006802 G2 box; other site 944547006803 G3 box; other site 944547006804 Switch II region; other site 944547006805 G4 box; other site 944547006806 G5 box; other site 944547006807 Nucleoside recognition; Region: Gate; pfam07670 944547006808 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 944547006809 Nucleoside recognition; Region: Gate; pfam07670 944547006810 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 944547006811 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 944547006812 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 944547006813 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 944547006814 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 944547006815 substrate binding site [chemical binding]; other site 944547006816 active site 944547006817 catalytic residues [active] 944547006818 heterodimer interface [polypeptide binding]; other site 944547006819 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 944547006820 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 944547006821 Cl- selectivity filter; other site 944547006822 Cl- binding residues [ion binding]; other site 944547006823 pore gating glutamate residue; other site 944547006824 dimer interface [polypeptide binding]; other site 944547006825 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 944547006826 active site 944547006827 oligomerization interface [polypeptide binding]; other site 944547006828 metal binding site [ion binding]; metal-binding site 944547006829 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 944547006830 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 944547006831 Walker A motif; other site 944547006832 ATP binding site [chemical binding]; other site 944547006833 Walker B motif; other site 944547006834 arginine finger; other site 944547006835 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 944547006836 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 944547006837 Domain of unknown function DUF20; Region: UPF0118; pfam01594 944547006838 Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; pfam02943 944547006839 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 944547006840 active site residue [active] 944547006841 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 944547006842 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 944547006843 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 944547006844 FeS/SAM binding site; other site 944547006845 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 944547006846 substrate binding site [chemical binding]; other site 944547006847 active site 944547006848 Uncharacterized protein family, UPF0114; Region: UPF0114; pfam03350 944547006849 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 944547006850 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 944547006851 DNA gyrase subunit A; Validated; Region: PRK05560 944547006852 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 944547006853 CAP-like domain; other site 944547006854 active site 944547006855 primary dimer interface [polypeptide binding]; other site 944547006856 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 944547006857 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 944547006858 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 944547006859 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 944547006860 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 944547006861 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 944547006862 Protein of unknown function (DUF465); Region: DUF465; cl01070 944547006863 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 944547006864 heterotetramer interface [polypeptide binding]; other site 944547006865 active site pocket [active] 944547006866 cleavage site 944547006867 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 944547006868 TrkA-N domain; Region: TrkA_N; pfam02254 944547006869 TrkA-C domain; Region: TrkA_C; pfam02080 944547006870 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 944547006871 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 944547006872 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 944547006873 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 944547006874 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 944547006875 putative ADP-binding pocket [chemical binding]; other site 944547006876 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 944547006877 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 944547006878 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 944547006879 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 944547006880 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 944547006881 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 944547006882 putative active site [active] 944547006883 putative metal binding site [ion binding]; other site 944547006884 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 944547006885 This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819 944547006886 putative ADP-binding pocket [chemical binding]; other site 944547006887 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 944547006888 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 944547006889 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 944547006890 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 944547006891 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 944547006892 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 944547006893 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 944547006894 putative acyl-acceptor binding pocket; other site 944547006895 exopolyphosphatase; Region: exo_poly_only; TIGR03706 944547006896 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 944547006897 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 944547006898 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 944547006899 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 944547006900 active site 944547006901 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 944547006902 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 944547006903 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 944547006904 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 944547006905 active site 944547006906 dimer interface [polypeptide binding]; other site 944547006907 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 944547006908 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 944547006909 active site 944547006910 FMN binding site [chemical binding]; other site 944547006911 substrate binding site [chemical binding]; other site 944547006912 3Fe-4S cluster binding site [ion binding]; other site 944547006913 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 944547006914 domain_subunit interface; other site 944547006915 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 944547006916 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 944547006917 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 944547006918 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 944547006919 DctM-like transporters; Region: DctM; pfam06808 944547006920 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 944547006921 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 944547006922 active site 944547006923 catalytic site [active] 944547006924 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 944547006925 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547006926 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547006927 ATP binding site [chemical binding]; other site 944547006928 Mg2+ binding site [ion binding]; other site 944547006929 G-X-G motif; other site 944547006930 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547006931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547006932 active site 944547006933 phosphorylation site [posttranslational modification] 944547006934 intermolecular recognition site; other site 944547006935 dimerization interface [polypeptide binding]; other site 944547006936 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 944547006937 DNA binding site [nucleotide binding] 944547006938 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 944547006939 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 944547006940 Radical SAM superfamily; Region: Radical_SAM; pfam04055 944547006941 FeS/SAM binding site; other site 944547006942 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 944547006943 NMT1/THI5 like; Region: NMT1; pfam09084 944547006944 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 944547006945 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 944547006946 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 944547006947 substrate binding pocket [chemical binding]; other site 944547006948 membrane-bound complex binding site; other site 944547006949 hinge residues; other site 944547006950 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 944547006951 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 944547006952 substrate binding pocket [chemical binding]; other site 944547006953 membrane-bound complex binding site; other site 944547006954 hinge residues; other site 944547006955 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547006956 dimer interface [polypeptide binding]; other site 944547006957 phosphorylation site [posttranslational modification] 944547006958 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547006959 ATP binding site [chemical binding]; other site 944547006960 Mg2+ binding site [ion binding]; other site 944547006961 G-X-G motif; other site 944547006962 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 944547006963 active site 944547006964 dimer interface [polypeptide binding]; other site 944547006965 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 944547006966 putative RNA binding site [nucleotide binding]; other site 944547006967 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 944547006968 homopentamer interface [polypeptide binding]; other site 944547006969 active site 944547006970 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547006971 PAS domain; Region: PAS_9; pfam13426 944547006972 putative active site [active] 944547006973 heme pocket [chemical binding]; other site 944547006974 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547006975 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547006976 metal binding site [ion binding]; metal-binding site 944547006977 active site 944547006978 I-site; other site 944547006979 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 944547006980 Ion channel; Region: Ion_trans_2; pfam07885 944547006981 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 944547006982 TrkA-N domain; Region: TrkA_N; pfam02254 944547006983 TrkA-N domain; Region: TrkA_N; pfam02254 944547006984 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 944547006985 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 944547006986 active site 944547006987 FMN binding site [chemical binding]; other site 944547006988 substrate binding site [chemical binding]; other site 944547006989 3Fe-4S cluster binding site [ion binding]; other site 944547006990 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 944547006991 EamA-like transporter family; Region: EamA; cl17759 944547006992 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 944547006993 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 944547006994 hinge; other site 944547006995 active site 944547006996 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 944547006997 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 944547006998 Walker A motif; other site 944547006999 ATP binding site [chemical binding]; other site 944547007000 Walker B motif; other site 944547007001 type II secretion system protein D; Region: type_II_gspD; TIGR02517 944547007002 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 944547007003 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 944547007004 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 944547007005 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 944547007006 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 944547007007 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 944547007008 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 944547007009 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 944547007010 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 944547007011 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 944547007012 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 944547007013 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 944547007014 Ca2+ binding site [ion binding]; other site 944547007015 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 944547007016 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 944547007017 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 944547007018 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 944547007019 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 944547007020 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 944547007021 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 944547007022 Ca2+ binding site [ion binding]; other site 944547007023 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 944547007024 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 944547007025 Uncharacterized conserved protein [Function unknown]; Region: COG1739 944547007026 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 944547007027 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 944547007028 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 944547007029 RNA binding surface [nucleotide binding]; other site 944547007030 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944547007031 S-adenosylmethionine binding site [chemical binding]; other site 944547007032 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 944547007033 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 944547007034 active site 944547007035 nucleotide binding site [chemical binding]; other site 944547007036 HIGH motif; other site 944547007037 KMSKS motif; other site 944547007038 Riboflavin kinase; Region: Flavokinase; smart00904 944547007039 Methyltransferase domain; Region: Methyltransf_23; pfam13489 944547007040 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944547007041 S-adenosylmethionine binding site [chemical binding]; other site 944547007042 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 944547007043 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 944547007044 catalytic triad [active] 944547007045 FAD binding domain; Region: FAD_binding_4; pfam01565 944547007046 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 944547007047 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 944547007048 Catalytic domain of Protein Kinases; Region: PKc; cd00180 944547007049 active site 944547007050 ATP binding site [chemical binding]; other site 944547007051 substrate binding site [chemical binding]; other site 944547007052 activation loop (A-loop); other site 944547007053 Predicted ATPase [General function prediction only]; Region: COG3899 944547007054 AAA ATPase domain; Region: AAA_16; pfam13191 944547007055 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 944547007056 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 944547007057 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547007058 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547007059 metal binding site [ion binding]; metal-binding site 944547007060 active site 944547007061 I-site; other site 944547007062 Cytochrome c; Region: Cytochrom_C; cl11414 944547007063 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 944547007064 Clp amino terminal domain; Region: Clp_N; pfam02861 944547007065 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 944547007066 Walker A motif; other site 944547007067 ATP binding site [chemical binding]; other site 944547007068 Walker B motif; other site 944547007069 arginine finger; other site 944547007070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 944547007071 Walker A motif; other site 944547007072 ATP binding site [chemical binding]; other site 944547007073 Walker B motif; other site 944547007074 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 944547007075 Uncharacterized conserved protein [Function unknown]; Region: COG2127 944547007076 AAA domain; Region: AAA_26; pfam13500 944547007077 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 944547007078 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 944547007079 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 944547007080 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 944547007081 acyl-activating enzyme (AAE) consensus motif; other site 944547007082 AMP binding site [chemical binding]; other site 944547007083 active site 944547007084 CoA binding site [chemical binding]; other site 944547007085 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 944547007086 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 944547007087 putative active site [active] 944547007088 putative catalytic site [active] 944547007089 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 944547007090 putative active site [active] 944547007091 putative catalytic site [active] 944547007092 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 944547007093 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 944547007094 Fumarase C-terminus; Region: Fumerase_C; pfam05683 944547007095 Nitrate and nitrite sensing; Region: NIT; pfam08376 944547007096 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 944547007097 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944547007098 dimer interface [polypeptide binding]; other site 944547007099 putative CheW interface [polypeptide binding]; other site 944547007100 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 944547007101 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 944547007102 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 944547007103 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 944547007104 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 944547007105 H+ Antiporter protein; Region: 2A0121; TIGR00900 944547007106 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 944547007107 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 944547007108 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 944547007109 molybdopterin cofactor binding site; other site 944547007110 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 944547007111 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 944547007112 Oxygen tolerance; Region: BatD; pfam13584 944547007113 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 944547007114 FHIPEP family; Region: FHIPEP; pfam00771 944547007115 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 944547007116 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 944547007117 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08472 944547007118 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 944547007119 Walker A motif/ATP binding site; other site 944547007120 Walker B motif; other site 944547007121 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 944547007122 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 944547007123 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 944547007124 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 944547007125 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 944547007126 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 944547007127 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 944547007128 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 944547007129 AAA domain; Region: AAA_31; pfam13614 944547007130 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 944547007131 Flagellar GTP-binding protein [Cell motility and secretion]; Region: FlhF; COG1419 944547007132 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 944547007133 Rod binding protein; Region: Rod-binding; cl01626 944547007134 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 944547007135 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 944547007136 ligand binding site [chemical binding]; other site 944547007137 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 944547007138 flagellar motor switch protein FliY; Validated; Region: PRK08432 944547007139 flagellar motor switch protein FliN; Region: fliN; TIGR02480 944547007140 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 944547007141 binding surface 944547007142 TPR motif; other site 944547007143 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 944547007144 flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506 944547007145 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 944547007146 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 944547007147 flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506 944547007148 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 944547007149 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 944547007150 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 944547007151 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 944547007152 Flagellar assembly protein FliH; Region: FliH; pfam02108 944547007153 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 944547007154 FliG C-terminal domain; Region: FliG_C; pfam01706 944547007155 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 944547007156 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 944547007157 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 944547007158 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 944547007159 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 944547007160 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 944547007161 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 944547007162 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 944547007163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547007164 active site 944547007165 phosphorylation site [posttranslational modification] 944547007166 intermolecular recognition site; other site 944547007167 dimerization interface [polypeptide binding]; other site 944547007168 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 944547007169 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 944547007170 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 944547007171 RimM protein, required for 16S rRNA processing [Translation, ribosomal structure and biogenesis]; Region: RimM; COG0806 944547007172 RimM N-terminal domain; Region: RimM; pfam01782 944547007173 KH domain; Region: KH_4; pfam13083 944547007174 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 944547007175 G-X-X-G motif; other site 944547007176 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 944547007177 signal recognition particle protein; Provisional; Region: PRK10867 944547007178 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 944547007179 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 944547007180 P loop; other site 944547007181 GTP binding site [chemical binding]; other site 944547007182 Signal peptide binding domain; Region: SRP_SPB; pfam02978 944547007183 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 944547007184 active site 944547007185 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 944547007186 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 944547007187 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 944547007188 Putative zinc ribbon domain; Region: DUF164; pfam02591 944547007189 Uncharacterized conserved protein [Function unknown]; Region: COG0327 944547007190 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 944547007191 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 944547007192 dimer interface [polypeptide binding]; other site 944547007193 motif 1; other site 944547007194 active site 944547007195 motif 2; other site 944547007196 motif 3; other site 944547007197 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 944547007198 catalytic residues [active] 944547007199 AIR carboxylase; Region: AIRC; smart01001 944547007200 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 944547007201 Peptidase family U32; Region: Peptidase_U32; pfam01136 944547007202 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 944547007203 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 944547007204 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 944547007205 dimerization interface [polypeptide binding]; other site 944547007206 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 944547007207 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944547007208 dimer interface [polypeptide binding]; other site 944547007209 putative CheW interface [polypeptide binding]; other site 944547007210 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 944547007211 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 944547007212 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 944547007213 Walker A/P-loop; other site 944547007214 ATP binding site [chemical binding]; other site 944547007215 Q-loop/lid; other site 944547007216 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 944547007217 ABC transporter signature motif; other site 944547007218 Walker B; other site 944547007219 D-loop; other site 944547007220 H-loop/switch region; other site 944547007221 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 944547007222 ATP-NAD kinase; Region: NAD_kinase; pfam01513 944547007223 elongation factor G; Reviewed; Region: PRK00007 944547007224 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 944547007225 G1 box; other site 944547007226 putative GEF interaction site [polypeptide binding]; other site 944547007227 GTP/Mg2+ binding site [chemical binding]; other site 944547007228 Switch I region; other site 944547007229 G2 box; other site 944547007230 G3 box; other site 944547007231 Switch II region; other site 944547007232 G4 box; other site 944547007233 G5 box; other site 944547007234 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 944547007235 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 944547007236 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 944547007237 30S ribosomal protein S7; Validated; Region: PRK05302 944547007238 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 944547007239 S17 interaction site [polypeptide binding]; other site 944547007240 S8 interaction site; other site 944547007241 16S rRNA interaction site [nucleotide binding]; other site 944547007242 streptomycin interaction site [chemical binding]; other site 944547007243 23S rRNA interaction site [nucleotide binding]; other site 944547007244 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 944547007245 MFS transport protein AraJ; Provisional; Region: PRK10091 944547007246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 944547007247 putative substrate translocation pore; other site 944547007248 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 944547007249 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 944547007250 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944547007251 dimer interface [polypeptide binding]; other site 944547007252 putative CheW interface [polypeptide binding]; other site 944547007253 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 944547007254 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 944547007255 Walker A/P-loop; other site 944547007256 ATP binding site [chemical binding]; other site 944547007257 ABC transporter; Region: ABC_tran; pfam00005 944547007258 Q-loop/lid; other site 944547007259 ABC transporter signature motif; other site 944547007260 Walker B; other site 944547007261 D-loop; other site 944547007262 Cobalt transport protein; Region: CbiQ; cl00463 944547007263 cobalt transport protein CbiM; Validated; Region: PRK06265 944547007264 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 944547007265 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 944547007266 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 944547007267 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 944547007268 HlyD family secretion protein; Region: HlyD_3; pfam13437 944547007269 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 944547007270 VCBS repeat; Region: VCBS_repeat; TIGR01965 944547007271 VCBS repeat; Region: VCBS_repeat; TIGR01965 944547007272 Cadherin repeat-like domain; Region: CA_like; cl15786 944547007273 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 944547007274 Ca2+ binding site [ion binding]; other site 944547007275 VCBS repeat; Region: VCBS_repeat; TIGR01965 944547007276 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 944547007277 Cadherin repeat-like domain; Region: CA_like; cl15786 944547007278 Ca2+ binding site [ion binding]; other site 944547007279 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 944547007280 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 944547007281 AAA domain; Region: AAA_17; cl17253 944547007282 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 944547007283 Prephenate dehydratase; Region: PDT; pfam00800 944547007284 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 944547007285 putative L-Phe binding site [chemical binding]; other site 944547007286 outer membrane porin, OprD family; Region: OprD; pfam03573 944547007287 Predicted permeases [General function prediction only]; Region: COG0679 944547007288 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 944547007289 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 944547007290 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 944547007291 active site 1 [active] 944547007292 dimer interface [polypeptide binding]; other site 944547007293 hexamer interface [polypeptide binding]; other site 944547007294 active site 2 [active] 944547007295 4-oxalocrotonate decarboxylase; Region: catechol_dmpH; TIGR03218 944547007296 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 944547007297 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 944547007298 active site 944547007299 catalytic residues [active] 944547007300 metal binding site [ion binding]; metal-binding site 944547007301 DmpG-like communication domain; Region: DmpG_comm; pfam07836 944547007302 acetaldehyde dehydrogenase; Validated; Region: PRK08300 944547007303 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 944547007304 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 944547007305 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 944547007306 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 944547007307 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 944547007308 NAD binding site [chemical binding]; other site 944547007309 catalytic residues [active] 944547007310 Domain of unknown function (DUF336); Region: DUF336; pfam03928 944547007311 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 944547007312 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 944547007313 active site 944547007314 metal binding site [ion binding]; metal-binding site 944547007315 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 944547007316 active site 944547007317 metal binding site [ion binding]; metal-binding site 944547007318 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 944547007319 catalytic loop [active] 944547007320 iron binding site [ion binding]; other site 944547007321 malate dehydrogenase; Reviewed; Region: PRK06223 944547007322 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 944547007323 dimer interface [polypeptide binding]; other site 944547007324 NAD(P) binding site [chemical binding]; other site 944547007325 tetramer (dimer of dimers) interface [polypeptide binding]; other site 944547007326 substrate binding site [chemical binding]; other site 944547007327 PAS domain S-box; Region: sensory_box; TIGR00229 944547007328 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547007329 putative active site [active] 944547007330 heme pocket [chemical binding]; other site 944547007331 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 944547007332 Histidine kinase; Region: HisKA_2; pfam07568 944547007333 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 944547007334 ATP binding site [chemical binding]; other site 944547007335 Mg2+ binding site [ion binding]; other site 944547007336 G-X-G motif; other site 944547007337 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547007338 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547007339 active site 944547007340 phosphorylation site [posttranslational modification] 944547007341 intermolecular recognition site; other site 944547007342 dimerization interface [polypeptide binding]; other site 944547007343 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 944547007344 DNA binding site [nucleotide binding] 944547007345 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 944547007346 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 944547007347 ligand binding site [chemical binding]; other site 944547007348 flexible hinge region; other site 944547007349 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 944547007350 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 944547007351 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 944547007352 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 944547007353 catalytic loop [active] 944547007354 iron binding site [ion binding]; other site 944547007355 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 944547007356 FAD binding pocket [chemical binding]; other site 944547007357 conserved FAD binding motif [chemical binding]; other site 944547007358 phosphate binding motif [ion binding]; other site 944547007359 beta-alpha-beta structure motif; other site 944547007360 NAD binding pocket [chemical binding]; other site 944547007361 Phenol hydroxylase conserved region; Region: Phenol_monoox; pfam04663 944547007362 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 944547007363 dinuclear metal binding motif [ion binding]; other site 944547007364 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 944547007365 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 944547007366 dinuclear metal binding motif [ion binding]; other site 944547007367 Phenol hydroxylase subunit; Region: Phenol_hyd_sub; pfam06099 944547007368 PAS domain; Region: PAS_9; pfam13426 944547007369 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 944547007370 Histidine kinase; Region: HisKA_2; pfam07568 944547007371 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 944547007372 ATP binding site [chemical binding]; other site 944547007373 Mg2+ binding site [ion binding]; other site 944547007374 G-X-G motif; other site 944547007375 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547007376 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547007377 active site 944547007378 phosphorylation site [posttranslational modification] 944547007379 intermolecular recognition site; other site 944547007380 dimerization interface [polypeptide binding]; other site 944547007381 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 944547007382 DNA binding site [nucleotide binding] 944547007383 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 944547007384 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944547007385 dimer interface [polypeptide binding]; other site 944547007386 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 944547007387 putative CheW interface [polypeptide binding]; other site 944547007388 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 944547007389 classical (c) SDRs; Region: SDR_c; cd05233 944547007390 NAD(P) binding site [chemical binding]; other site 944547007391 active site 944547007392 tartrate dehydrogenase; Region: TTC; TIGR02089 944547007393 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 944547007394 YCII-related domain; Region: YCII; cl00999 944547007395 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 944547007396 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 944547007397 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 944547007398 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 944547007399 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 944547007400 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 944547007401 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 944547007402 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 944547007403 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 944547007404 DNA binding site [nucleotide binding] 944547007405 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 944547007406 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 944547007407 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 944547007408 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 944547007409 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 944547007410 RPB3 interaction site [polypeptide binding]; other site 944547007411 RPB1 interaction site [polypeptide binding]; other site 944547007412 RPB11 interaction site [polypeptide binding]; other site 944547007413 RPB10 interaction site [polypeptide binding]; other site 944547007414 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 944547007415 L11 interface [polypeptide binding]; other site 944547007416 putative EF-Tu interaction site [polypeptide binding]; other site 944547007417 putative EF-G interaction site [polypeptide binding]; other site 944547007418 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 944547007419 23S rRNA interface [nucleotide binding]; other site 944547007420 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 944547007421 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 944547007422 mRNA/rRNA interface [nucleotide binding]; other site 944547007423 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 944547007424 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 944547007425 23S rRNA interface [nucleotide binding]; other site 944547007426 L7/L12 interface [polypeptide binding]; other site 944547007427 putative thiostrepton binding site; other site 944547007428 L25 interface [polypeptide binding]; other site 944547007429 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 944547007430 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 944547007431 putative homodimer interface [polypeptide binding]; other site 944547007432 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 944547007433 heterodimer interface [polypeptide binding]; other site 944547007434 homodimer interface [polypeptide binding]; other site 944547007435 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 944547007436 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 944547007437 elongation factor Tu; Reviewed; Region: PRK00049 944547007438 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 944547007439 G1 box; other site 944547007440 GEF interaction site [polypeptide binding]; other site 944547007441 GTP/Mg2+ binding site [chemical binding]; other site 944547007442 Switch I region; other site 944547007443 G2 box; other site 944547007444 G3 box; other site 944547007445 Switch II region; other site 944547007446 G4 box; other site 944547007447 G5 box; other site 944547007448 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 944547007449 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 944547007450 Antibiotic Binding Site [chemical binding]; other site 944547007451 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03815 944547007452 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 944547007453 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 944547007454 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 944547007455 Mg++ binding site [ion binding]; other site 944547007456 putative catalytic motif [active] 944547007457 putative substrate binding site [chemical binding]; other site 944547007458 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 944547007459 phosphoglyceromutase; Provisional; Region: PRK05434 944547007460 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 944547007461 Q-loop/lid; other site 944547007462 ABC transporter signature motif; other site 944547007463 Walker B; other site 944547007464 D-loop; other site 944547007465 H-loop/switch region; other site 944547007466 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 944547007467 Transglycosylase; Region: Transgly; pfam00912 944547007468 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 944547007469 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 944547007470 glutamine synthetase, type I; Region: GlnA; TIGR00653 944547007471 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 944547007472 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 944547007473 histidinol-phosphatase; Provisional; Region: PRK07328 944547007474 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 944547007475 active site 944547007476 dimer interface [polypeptide binding]; other site 944547007477 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 944547007478 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547007479 active site 944547007480 phosphorylation site [posttranslational modification] 944547007481 intermolecular recognition site; other site 944547007482 dimerization interface [polypeptide binding]; other site 944547007483 Response regulator receiver domain; Region: Response_reg; pfam00072 944547007484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547007485 active site 944547007486 phosphorylation site [posttranslational modification] 944547007487 intermolecular recognition site; other site 944547007488 dimerization interface [polypeptide binding]; other site 944547007489 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547007490 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547007491 metal binding site [ion binding]; metal-binding site 944547007492 active site 944547007493 I-site; other site 944547007494 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 944547007495 MoaE homodimer interface [polypeptide binding]; other site 944547007496 MoaD interaction [polypeptide binding]; other site 944547007497 active site residues [active] 944547007498 ThiS family; Region: ThiS; pfam02597 944547007499 charged pocket; other site 944547007500 hydrophobic patch; other site 944547007501 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 944547007502 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 944547007503 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 944547007504 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 944547007505 homodimer interface [polypeptide binding]; other site 944547007506 active site 944547007507 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 944547007508 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 944547007509 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 944547007510 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 944547007511 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 944547007512 active site 944547007513 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 944547007514 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 944547007515 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 944547007516 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 944547007517 glutamine binding [chemical binding]; other site 944547007518 catalytic triad [active] 944547007519 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 944547007520 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 944547007521 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 944547007522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 944547007523 dimer interface [polypeptide binding]; other site 944547007524 conserved gate region; other site 944547007525 putative PBP binding loops; other site 944547007526 ABC-ATPase subunit interface; other site 944547007527 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 944547007528 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 944547007529 Walker A/P-loop; other site 944547007530 ATP binding site [chemical binding]; other site 944547007531 Q-loop/lid; other site 944547007532 ABC transporter signature motif; other site 944547007533 Walker B; other site 944547007534 D-loop; other site 944547007535 H-loop/switch region; other site 944547007536 TOBE domain; Region: TOBE_2; pfam08402 944547007537 NMT1/THI5 like; Region: NMT1; pfam09084 944547007538 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 944547007539 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 944547007540 substrate binding pocket [chemical binding]; other site 944547007541 membrane-bound complex binding site; other site 944547007542 hinge residues; other site 944547007543 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547007544 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547007545 metal binding site [ion binding]; metal-binding site 944547007546 active site 944547007547 I-site; other site 944547007548 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 944547007549 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 944547007550 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 944547007551 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 944547007552 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cd03873 944547007553 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cd03873 944547007554 metal binding site [ion binding]; metal-binding site 944547007555 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 944547007556 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 944547007557 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 944547007558 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 944547007559 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 944547007560 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 944547007561 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 944547007562 RNA binding site [nucleotide binding]; other site 944547007563 TIR domain; Region: TIR_2; cl17458 944547007564 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 944547007565 homotrimer interaction site [polypeptide binding]; other site 944547007566 putative active site [active] 944547007567 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 944547007568 nudix motif; other site 944547007569 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 944547007570 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 944547007571 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 944547007572 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 944547007573 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 944547007574 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944547007575 homodimer interface [polypeptide binding]; other site 944547007576 catalytic residue [active] 944547007577 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 944547007578 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 944547007579 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 944547007580 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 944547007581 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 944547007582 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 944547007583 THF binding site; other site 944547007584 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 944547007585 substrate binding site [chemical binding]; other site 944547007586 THF binding site; other site 944547007587 zinc-binding site [ion binding]; other site 944547007588 threonine dehydratase; Provisional; Region: PRK08526 944547007589 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 944547007590 tetramer interface [polypeptide binding]; other site 944547007591 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944547007592 catalytic residue [active] 944547007593 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 944547007594 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 944547007595 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 944547007596 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 944547007597 thiamine phosphate binding site [chemical binding]; other site 944547007598 active site 944547007599 pyrophosphate binding site [ion binding]; other site 944547007600 putative recombination protein RecB; Provisional; Region: PRK13909 944547007601 Part of AAA domain; Region: AAA_19; pfam13245 944547007602 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 944547007603 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 944547007604 feedback inhibition sensing region; other site 944547007605 homohexameric interface [polypeptide binding]; other site 944547007606 nucleotide binding site [chemical binding]; other site 944547007607 N-acetyl-L-glutamate binding site [chemical binding]; other site 944547007608 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 944547007609 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 944547007610 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944547007611 catalytic residue [active] 944547007612 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 944547007613 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 944547007614 iron-sulfur cluster [ion binding]; other site 944547007615 [2Fe-2S] cluster binding site [ion binding]; other site 944547007616 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 944547007617 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 944547007618 intrachain domain interface; other site 944547007619 interchain domain interface [polypeptide binding]; other site 944547007620 heme bH binding site [chemical binding]; other site 944547007621 Qi binding site; other site 944547007622 heme bL binding site [chemical binding]; other site 944547007623 Qo binding site; other site 944547007624 interchain domain interface [polypeptide binding]; other site 944547007625 intrachain domain interface; other site 944547007626 Qi binding site; other site 944547007627 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 944547007628 Qo binding site; other site 944547007629 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 944547007630 Cytochrome c; Region: Cytochrom_C; pfam00034 944547007631 RNA methyltransferase, RsmE family; Region: TIGR00046 944547007632 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 944547007633 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 944547007634 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 944547007635 dimer interface [polypeptide binding]; other site 944547007636 putative functional site; other site 944547007637 putative MPT binding site; other site 944547007638 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 944547007639 Ligand Binding Site [chemical binding]; other site 944547007640 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 944547007641 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 944547007642 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 944547007643 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 944547007644 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 944547007645 NAD(P) binding site [chemical binding]; other site 944547007646 active site 944547007647 acyl carrier protein; Provisional; Region: acpP; PRK00982 944547007648 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK08439 944547007649 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 944547007650 dimer interface [polypeptide binding]; other site 944547007651 active site 944547007652 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 944547007653 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 944547007654 nucleotide binding site/active site [active] 944547007655 HIT family signature motif; other site 944547007656 catalytic residue [active] 944547007657 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 944547007658 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 944547007659 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 944547007660 dimer interface [polypeptide binding]; other site 944547007661 motif 1; other site 944547007662 active site 944547007663 motif 2; other site 944547007664 motif 3; other site 944547007665 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 944547007666 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 944547007667 putative tRNA-binding site [nucleotide binding]; other site 944547007668 tRNA synthetase B5 domain; Region: B5; smart00874 944547007669 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 944547007670 dimer interface [polypeptide binding]; other site 944547007671 motif 1; other site 944547007672 motif 3; other site 944547007673 motif 2; other site 944547007674 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 944547007675 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 944547007676 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 944547007677 hinge; other site 944547007678 active site 944547007679 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 944547007680 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 944547007681 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 944547007682 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 944547007683 RNA binding site [nucleotide binding]; other site 944547007684 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 944547007685 RNA binding site [nucleotide binding]; other site 944547007686 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 944547007687 RNA binding site [nucleotide binding]; other site 944547007688 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 944547007689 RNA binding site [nucleotide binding]; other site 944547007690 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 944547007691 RNA binding site [nucleotide binding]; other site 944547007692 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 944547007693 RNA binding site [nucleotide binding]; other site 944547007694 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 944547007695 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 944547007696 ligand binding site [chemical binding]; other site 944547007697 NAD binding site [chemical binding]; other site 944547007698 dimerization interface [polypeptide binding]; other site 944547007699 catalytic site [active] 944547007700 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 944547007701 putative L-serine binding site [chemical binding]; other site 944547007702 elongation factor P; Validated; Region: PRK00529 944547007703 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 944547007704 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 944547007705 RNA binding site [nucleotide binding]; other site 944547007706 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 944547007707 RNA binding site [nucleotide binding]; other site 944547007708 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 944547007709 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 944547007710 catalytic motif [active] 944547007711 Zn binding site [ion binding]; other site 944547007712 RibD C-terminal domain; Region: RibD_C; cl17279 944547007713 ribosome maturation protein RimP; Reviewed; Region: PRK00092 944547007714 Sm and related proteins; Region: Sm_like; cl00259 944547007715 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 944547007716 putative oligomer interface [polypeptide binding]; other site 944547007717 putative RNA binding site [nucleotide binding]; other site 944547007718 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 944547007719 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 944547007720 translation initiation factor IF-2; Region: IF-2; TIGR00487 944547007721 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 944547007722 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 944547007723 G1 box; other site 944547007724 putative GEF interaction site [polypeptide binding]; other site 944547007725 GTP/Mg2+ binding site [chemical binding]; other site 944547007726 Switch I region; other site 944547007727 G2 box; other site 944547007728 G3 box; other site 944547007729 Switch II region; other site 944547007730 G4 box; other site 944547007731 G5 box; other site 944547007732 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 944547007733 Translation-initiation factor 2; Region: IF-2; pfam11987 944547007734 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 944547007735 homoserine kinase; Provisional; Region: PRK01212 944547007736 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 944547007737 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 944547007738 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 944547007739 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 944547007740 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 944547007741 Peptidase family M23; Region: Peptidase_M23; pfam01551 944547007742 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 944547007743 DHH family; Region: DHH; pfam01368 944547007744 DHHA1 domain; Region: DHHA1; pfam02272 944547007745 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05848 944547007746 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 944547007747 dimerization interface [polypeptide binding]; other site 944547007748 active site 944547007749 quinolinate synthetase; Provisional; Region: PRK09375 944547007750 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 944547007751 Dihydroneopterin aldolase; Region: FolB; pfam02152 944547007752 active site 944547007753 Campylobacter major outer membrane protein; Region: Campylo_MOMP; pfam05538 944547007754 outer membrane porin, OprD family; Region: OprD; pfam03573 944547007755 Cytochrome c; Region: Cytochrom_C; pfam00034 944547007756 peptide chain release factor 2; Validated; Region: prfB; PRK00578 944547007757 This domain is found in peptide chain release factors; Region: PCRF; smart00937 944547007758 RF-1 domain; Region: RF-1; pfam00472 944547007759 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 944547007760 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 944547007761 HlyD family secretion protein; Region: HlyD_3; pfam13437 944547007762 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 944547007763 Fusaric acid resistance protein family; Region: FUSC; pfam04632 944547007764 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 944547007765 Outer membrane efflux protein; Region: OEP; pfam02321 944547007766 Outer membrane efflux protein; Region: OEP; pfam02321 944547007767 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 944547007768 MarR family; Region: MarR_2; pfam12802 944547007769 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 944547007770 FixH; Region: FixH; pfam05751 944547007771 Family of unknown function (DUF4006); Region: DUF4006; pfam13179 944547007772 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 944547007773 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 944547007774 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 944547007775 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 944547007776 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 944547007777 cbb3-type cytochrome c oxidase subunit I; Provisional; Region: PRK14488 944547007778 Low-spin heme binding site [chemical binding]; other site 944547007779 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 944547007780 D-pathway; other site 944547007781 Putative water exit pathway; other site 944547007782 Binuclear center (active site) [active] 944547007783 K-pathway; other site 944547007784 Putative proton exit pathway; other site 944547007785 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 944547007786 SmpB-tmRNA interface; other site 944547007787 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK04181 944547007788 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 944547007789 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK04099 944547007790 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 944547007791 RNA binding site [nucleotide binding]; other site 944547007792 active site 944547007793 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 944547007794 Part of AAA domain; Region: AAA_19; pfam13245 944547007795 Family description; Region: UvrD_C_2; pfam13538 944547007796 Transcriptional regulator [Transcription]; Region: LysR; COG0583 944547007797 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 944547007798 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 944547007799 dimerization interface [polypeptide binding]; other site 944547007800 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 944547007801 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 944547007802 amidophosphoribosyltransferase; Provisional; Region: PRK08525 944547007803 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 944547007804 active site 944547007805 tetramer interface [polypeptide binding]; other site 944547007806 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 944547007807 active site 944547007808 dihydrodipicolinate reductase; Provisional; Region: PRK00048 944547007809 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 944547007810 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 944547007811 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 944547007812 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 944547007813 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 944547007814 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 944547007815 catalytic residues [active] 944547007816 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 944547007817 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 944547007818 motif 1; other site 944547007819 active site 944547007820 motif 2; other site 944547007821 motif 3; other site 944547007822 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 944547007823 DHHA1 domain; Region: DHHA1; pfam02272 944547007824 Predicted integral membrane protein [Function unknown]; Region: COG5615 944547007825 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 944547007826 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 944547007827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 944547007828 Major Facilitator Superfamily; Region: MFS_1; pfam07690 944547007829 putative substrate translocation pore; other site 944547007830 NlpC/P60 family; Region: NLPC_P60; pfam00877 944547007831 NlpC/P60 family; Region: NLPC_P60; pfam00877 944547007832 Membrane transport protein; Region: Mem_trans; cl09117 944547007833 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 944547007834 EamA-like transporter family; Region: EamA; pfam00892 944547007835 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 944547007836 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 944547007837 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 944547007838 Maf-like protein; Reviewed; Region: PRK04056 944547007839 Maf-like protein; Region: Maf; pfam02545 944547007840 putative active site [active] 944547007841 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 944547007842 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 944547007843 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 944547007844 TPP-binding site; other site 944547007845 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 944547007846 PYR/PP interface [polypeptide binding]; other site 944547007847 dimer interface [polypeptide binding]; other site 944547007848 TPP binding site [chemical binding]; other site 944547007849 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 944547007850 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 944547007851 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 944547007852 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944547007853 homodimer interface [polypeptide binding]; other site 944547007854 catalytic residue [active] 944547007855 Chorismate mutase type II; Region: CM_2; cl00693 944547007856 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 944547007857 Prephenate dehydratase; Region: PDT; pfam00800 944547007858 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 944547007859 putative L-Phe binding site [chemical binding]; other site 944547007860 diaminopimelate decarboxylase; Region: lysA; TIGR01048 944547007861 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 944547007862 active site 944547007863 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 944547007864 substrate binding site [chemical binding]; other site 944547007865 catalytic residues [active] 944547007866 dimer interface [polypeptide binding]; other site 944547007867 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08415 944547007868 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 944547007869 NAD binding site [chemical binding]; other site 944547007870 homotetramer interface [polypeptide binding]; other site 944547007871 homodimer interface [polypeptide binding]; other site 944547007872 substrate binding site [chemical binding]; other site 944547007873 active site 944547007874 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 944547007875 triosephosphate isomerase; Provisional; Region: PRK14565 944547007876 substrate binding site [chemical binding]; other site 944547007877 dimer interface [polypeptide binding]; other site 944547007878 catalytic triad [active] 944547007879 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 944547007880 Phosphoglycerate kinase; Region: PGK; pfam00162 944547007881 substrate binding site [chemical binding]; other site 944547007882 hinge regions; other site 944547007883 ADP binding site [chemical binding]; other site 944547007884 catalytic site [active] 944547007885 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 944547007886 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 944547007887 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 944547007888 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 944547007889 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 944547007890 active site 944547007891 (T/H)XGH motif; other site 944547007892 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 944547007893 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 944547007894 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 944547007895 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 944547007896 active site 944547007897 HIGH motif; other site 944547007898 KMSK motif region; other site 944547007899 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 944547007900 tRNA binding surface [nucleotide binding]; other site 944547007901 anticodon binding site; other site 944547007902 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 944547007903 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 944547007904 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 944547007905 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 944547007906 putative acyl-acceptor binding pocket; other site 944547007907 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 944547007908 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 944547007909 putative active site [active] 944547007910 catalytic triad [active] 944547007911 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 944547007912 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231 944547007913 ATP binding site [chemical binding]; other site 944547007914 active site 944547007915 substrate binding site [chemical binding]; other site 944547007916 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 944547007917 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 944547007918 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 944547007919 protein binding site [polypeptide binding]; other site 944547007920 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 944547007921 Catalytic dyad [active] 944547007922 PQQ-like domain; Region: PQQ_2; pfam13360 944547007923 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 944547007924 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 944547007925 active site 944547007926 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 944547007927 FtsX-like permease family; Region: FtsX; pfam02687 944547007928 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 944547007929 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 944547007930 Walker A/P-loop; other site 944547007931 ATP binding site [chemical binding]; other site 944547007932 Q-loop/lid; other site 944547007933 ABC transporter signature motif; other site 944547007934 Walker B; other site 944547007935 D-loop; other site 944547007936 H-loop/switch region; other site 944547007937 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547007938 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547007939 dimer interface [polypeptide binding]; other site 944547007940 phosphorylation site [posttranslational modification] 944547007941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547007942 ATP binding site [chemical binding]; other site 944547007943 Mg2+ binding site [ion binding]; other site 944547007944 G-X-G motif; other site 944547007945 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 944547007946 nucleotidyl binding site; other site 944547007947 metal binding site [ion binding]; metal-binding site 944547007948 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 944547007949 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 944547007950 Helix-turn-helix domain; Region: HTH_38; pfam13936 944547007951 Homeodomain-like domain; Region: HTH_32; pfam13565 944547007952 Integrase core domain; Region: rve; pfam00665 944547007953 Integrase core domain; Region: rve_3; cl15866 944547007954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547007955 active site 944547007956 phosphorylation site [posttranslational modification] 944547007957 intermolecular recognition site; other site 944547007958 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 944547007959 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 944547007960 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 944547007961 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 944547007962 protein binding site [polypeptide binding]; other site 944547007963 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 944547007964 protein binding site [polypeptide binding]; other site 944547007965 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547007966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547007967 active site 944547007968 phosphorylation site [posttranslational modification] 944547007969 intermolecular recognition site; other site 944547007970 dimerization interface [polypeptide binding]; other site 944547007971 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 944547007972 DNA binding site [nucleotide binding] 944547007973 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547007974 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 944547007975 dimerization interface [polypeptide binding]; other site 944547007976 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547007977 dimer interface [polypeptide binding]; other site 944547007978 phosphorylation site [posttranslational modification] 944547007979 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547007980 ATP binding site [chemical binding]; other site 944547007981 Mg2+ binding site [ion binding]; other site 944547007982 G-X-G motif; other site 944547007983 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 944547007984 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 944547007985 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 944547007986 putative NAD(P) binding site [chemical binding]; other site 944547007987 putative active site [active] 944547007988 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 944547007989 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 944547007990 non-specific DNA binding site [nucleotide binding]; other site 944547007991 salt bridge; other site 944547007992 sequence-specific DNA binding site [nucleotide binding]; other site 944547007993 cobyric acid synthase; Provisional; Region: PRK00784 944547007994 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 944547007995 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 944547007996 catalytic triad [active] 944547007997 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547007998 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 944547007999 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547008000 ATP binding site [chemical binding]; other site 944547008001 Mg2+ binding site [ion binding]; other site 944547008002 G-X-G motif; other site 944547008003 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 944547008004 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 944547008005 NAD(P) binding site [chemical binding]; other site 944547008006 active site 944547008007 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 944547008008 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 944547008009 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 944547008010 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944547008011 homodimer interface [polypeptide binding]; other site 944547008012 catalytic residue [active] 944547008013 Cobalamin-5-phosphate synthase [Coenzyme metabolism]; Region: CobS; COG0368 944547008014 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363 944547008015 MarC family integral membrane protein; Region: MarC; pfam01914 944547008016 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828 944547008017 active site 944547008018 catalytic triad [active] 944547008019 oxyanion hole [active] 944547008020 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 944547008021 putative dimer interface [polypeptide binding]; other site 944547008022 active site pocket [active] 944547008023 putative cataytic base [active] 944547008024 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 944547008025 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 944547008026 transmembrane helices; other site 944547008027 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 944547008028 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 944547008029 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 944547008030 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 944547008031 TraX protein; Region: TraX; cl05434 944547008032 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 944547008033 DsbD alpha interface [polypeptide binding]; other site 944547008034 catalytic residues [active] 944547008035 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 944547008036 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 944547008037 catalytic residues [active] 944547008038 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 944547008039 active site residue [active] 944547008040 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 944547008041 ATP-grasp domain; Region: ATP-grasp_4; cl17255 944547008042 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 944547008043 Cache domain; Region: Cache_1; pfam02743 944547008044 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547008045 metal binding site [ion binding]; metal-binding site 944547008046 active site 944547008047 I-site; other site 944547008048 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 944547008049 phosphatidylserine decarboxylase; Provisional; Region: PRK03934 944547008050 MltA specific insert domain; Region: MltA; smart00925 944547008051 3D domain; Region: 3D; pfam06725 944547008052 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 944547008053 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 944547008054 nucleotide binding site [chemical binding]; other site 944547008055 NEF interaction site [polypeptide binding]; other site 944547008056 SBD interface [polypeptide binding]; other site 944547008057 GrpE; Region: GrpE; pfam01025 944547008058 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 944547008059 dimer interface [polypeptide binding]; other site 944547008060 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 944547008061 heat-inducible transcription repressor; Provisional; Region: PRK03911 944547008062 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 944547008063 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 944547008064 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 944547008065 DctM-like transporters; Region: DctM; pfam06808 944547008066 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547008067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547008068 active site 944547008069 phosphorylation site [posttranslational modification] 944547008070 intermolecular recognition site; other site 944547008071 dimerization interface [polypeptide binding]; other site 944547008072 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 944547008073 DNA binding site [nucleotide binding] 944547008074 PAS domain S-box; Region: sensory_box; TIGR00229 944547008075 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547008076 putative active site [active] 944547008077 heme pocket [chemical binding]; other site 944547008078 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547008079 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547008080 dimer interface [polypeptide binding]; other site 944547008081 phosphorylation site [posttranslational modification] 944547008082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547008083 ATP binding site [chemical binding]; other site 944547008084 G-X-G motif; other site 944547008085 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 944547008086 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 944547008087 dimerization interface 3.5A [polypeptide binding]; other site 944547008088 active site 944547008089 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 944547008090 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 944547008091 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 944547008092 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 944547008093 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 944547008094 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 944547008095 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 944547008096 catalytic residue [active] 944547008097 putative FPP diphosphate binding site; other site 944547008098 putative FPP binding hydrophobic cleft; other site 944547008099 dimer interface [polypeptide binding]; other site 944547008100 putative IPP diphosphate binding site; other site 944547008101 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 944547008102 Flavoprotein; Region: Flavoprotein; pfam02441 944547008103 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 944547008104 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14359 944547008105 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 944547008106 Substrate binding site; other site 944547008107 Mg++ binding site; other site 944547008108 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 944547008109 active site 944547008110 substrate binding site [chemical binding]; other site 944547008111 CoA binding site [chemical binding]; other site 944547008112 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 944547008113 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 944547008114 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 944547008115 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 944547008116 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 944547008117 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 944547008118 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 944547008119 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 944547008120 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 944547008121 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 944547008122 nucleotide binding region [chemical binding]; other site 944547008123 ATP-binding site [chemical binding]; other site 944547008124 Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513 944547008125 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 944547008126 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944547008127 S-adenosylmethionine binding site [chemical binding]; other site 944547008128 flagellin; Provisional; Region: PRK12802 944547008129 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 944547008130 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 944547008131 flagellin; Provisional; Region: PRK12802 944547008132 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 944547008133 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 944547008134 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 944547008135 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 944547008136 ligand binding site; other site 944547008137 tetramer interface; other site 944547008138 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 944547008139 active site 944547008140 motif I; other site 944547008141 motif II; other site 944547008142 Methyltransferase domain; Region: Methyltransf_23; pfam13489 944547008143 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944547008144 S-adenosylmethionine binding site [chemical binding]; other site 944547008145 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 944547008146 NeuB family; Region: NeuB; pfam03102 944547008147 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 944547008148 FOG: CBS domain [General function prediction only]; Region: COG0517 944547008149 Cupin domain; Region: Cupin_2; cl17218 944547008150 recombinase A; Provisional; Region: recA; PRK09354 944547008151 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 944547008152 hexamer interface [polypeptide binding]; other site 944547008153 Walker A motif; other site 944547008154 ATP binding site [chemical binding]; other site 944547008155 Walker B motif; other site 944547008156 enolase; Provisional; Region: eno; PRK00077 944547008157 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 944547008158 dimer interface [polypeptide binding]; other site 944547008159 metal binding site [ion binding]; metal-binding site 944547008160 substrate binding pocket [chemical binding]; other site 944547008161 proteasome-activating nucleotidase; Provisional; Region: PRK03992 944547008162 AMIN domain; Region: AMIN; pfam11741 944547008163 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 944547008164 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 944547008165 biotin synthase; Provisional; Region: PRK08508 944547008166 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 944547008167 FeS/SAM binding site; other site 944547008168 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 944547008169 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 944547008170 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 944547008171 active site 944547008172 metal binding site [ion binding]; metal-binding site 944547008173 homotetramer interface [polypeptide binding]; other site 944547008174 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 944547008175 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 944547008176 active site 944547008177 metal binding site [ion binding]; metal-binding site 944547008178 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 944547008179 domain I; other site 944547008180 DNA binding groove [nucleotide binding] 944547008181 phosphate binding site [ion binding]; other site 944547008182 domain II; other site 944547008183 domain III; other site 944547008184 nucleotide binding site [chemical binding]; other site 944547008185 catalytic site [active] 944547008186 domain IV; other site 944547008187 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 944547008188 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13904 944547008189 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 944547008190 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 944547008191 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 944547008192 N-acetyl-D-glucosamine binding site [chemical binding]; other site 944547008193 catalytic residue [active] 944547008194 NADH dehydrogenase subunit 2; Provisional; Region: ND2; MTH00200 944547008195 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 944547008196 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 944547008197 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 944547008198 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 944547008199 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 944547008200 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 944547008201 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 944547008202 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 944547008203 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 944547008204 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 944547008205 4Fe-4S binding domain; Region: Fer4; pfam00037 944547008206 4Fe-4S binding domain; Region: Fer4; pfam00037 944547008207 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 944547008208 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 944547008209 NADH dehydrogenase subunit G; Validated; Region: PRK08493 944547008210 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 944547008211 catalytic loop [active] 944547008212 iron binding site [ion binding]; other site 944547008213 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 944547008214 4Fe-4S binding domain; Region: Fer4; pfam00037 944547008215 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 944547008216 NADH dehydrogenase subunit G; Validated; Region: PRK08493 944547008217 NADH dehydrogenase subunit G; Validated; Region: PRK08493 944547008218 NADH dehydrogenase subunit D; Validated; Region: PRK06075 944547008219 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 944547008220 NADH dehydrogenase subunit C; Provisional; Region: PRK08491 944547008221 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 944547008222 NADH dehydrogenase subunit B; Validated; Region: PRK06411 944547008223 NADH dehydrogenase subunit A; Validated; Region: PRK08489 944547008224 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 944547008225 ATPase family associated with various cellular activities (AAA); Region: AAA; pfam00004 944547008226 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 944547008227 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 944547008228 Sel1 repeat; Region: Sel1; cl02723 944547008229 Sel1 repeat; Region: Sel1; cl02723 944547008230 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 944547008231 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 944547008232 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 944547008233 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 944547008234 putative transporter; Provisional; Region: PRK11660 944547008235 Sulfate transporter family; Region: Sulfate_transp; pfam00916 944547008236 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 944547008237 endonuclease IV; Provisional; Region: PRK01060 944547008238 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 944547008239 AP (apurinic/apyrimidinic) site pocket; other site 944547008240 DNA interaction; other site 944547008241 Metal-binding active site; metal-binding site 944547008242 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 944547008243 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 944547008244 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 944547008245 Na2 binding site [ion binding]; other site 944547008246 putative substrate binding site 1 [chemical binding]; other site 944547008247 Na binding site 1 [ion binding]; other site 944547008248 putative substrate binding site 2 [chemical binding]; other site 944547008249 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 944547008250 Ligand Binding Site [chemical binding]; other site 944547008251 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 944547008252 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 944547008253 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 944547008254 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 944547008255 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 944547008256 active site 944547008257 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 944547008258 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 944547008259 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 944547008260 Walker A motif; other site 944547008261 ATP binding site [chemical binding]; other site 944547008262 Walker B motif; other site 944547008263 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 944547008264 rod shape-determining protein MreB; Provisional; Region: PRK13927 944547008265 MreB and similar proteins; Region: MreB_like; cd10225 944547008266 nucleotide binding site [chemical binding]; other site 944547008267 Mg binding site [ion binding]; other site 944547008268 putative protofilament interaction site [polypeptide binding]; other site 944547008269 RodZ interaction site [polypeptide binding]; other site 944547008270 rod shape-determining protein MreC; Provisional; Region: PRK13922 944547008271 rod shape-determining protein MreC; Region: MreC; pfam04085 944547008272 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 944547008273 Lumazine binding domain; Region: Lum_binding; pfam00677 944547008274 Lumazine binding domain; Region: Lum_binding; pfam00677 944547008275 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 944547008276 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 944547008277 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 944547008278 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 944547008279 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 944547008280 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 944547008281 4Fe-4S binding domain; Region: Fer4_5; pfam12801 944547008282 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 944547008283 CTP synthetase; Validated; Region: pyrG; PRK05380 944547008284 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 944547008285 Catalytic site [active] 944547008286 active site 944547008287 UTP binding site [chemical binding]; other site 944547008288 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 944547008289 active site 944547008290 putative oxyanion hole; other site 944547008291 catalytic triad [active] 944547008292 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 944547008293 DHH family; Region: DHH; pfam01368 944547008294 DHHA1 domain; Region: DHHA1; pfam02272 944547008295 Predicted integral membrane protein [Function unknown]; Region: COG5616 944547008296 DJ-1 family protein; Region: not_thiJ; TIGR01383 944547008297 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 944547008298 conserved cys residue [active] 944547008299 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 944547008300 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 944547008301 putative active site [active] 944547008302 putative metal binding site [ion binding]; other site 944547008303 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 944547008304 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 944547008305 active site 944547008306 nucleophile elbow; other site 944547008307 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 944547008308 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 944547008309 active site 944547008310 PHP Thumb interface [polypeptide binding]; other site 944547008311 metal binding site [ion binding]; metal-binding site 944547008312 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 944547008313 generic binding surface II; other site 944547008314 generic binding surface I; other site 944547008315 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 944547008316 Protein of unknown function (DUF493); Region: DUF493; pfam04359 944547008317 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 944547008318 trimer interface [polypeptide binding]; other site 944547008319 dimer interface [polypeptide binding]; other site 944547008320 putative active site [active] 944547008321 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 944547008322 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 944547008323 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 944547008324 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 944547008325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944547008326 S-adenosylmethionine binding site [chemical binding]; other site 944547008327 Preprotein translocase SecG subunit; Region: SecG; pfam03840 944547008328 Putative catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u4_5s; cd10973 944547008329 putative active site [active] 944547008330 putative metal binding site [ion binding]; other site 944547008331 ribosome recycling factor; Reviewed; Region: frr; PRK00083 944547008332 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 944547008333 hinge region; other site 944547008334 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 944547008335 active site 944547008336 RDD family; Region: RDD; pfam06271 944547008337 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 944547008338 Mechanosensitive ion channel; Region: MS_channel; pfam00924 944547008339 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 944547008340 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 944547008341 Cl binding site [ion binding]; other site 944547008342 oligomer interface [polypeptide binding]; other site 944547008343 Protein of unknown function (DUF328); Region: DUF328; pfam03883 944547008344 hypothetical protein; Provisional; Region: PRK04233 944547008345 SEC-C motif; Region: SEC-C; pfam02810 944547008346 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 944547008347 Helix-hairpin-helix motif; Region: HHH; pfam00633 944547008348 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 944547008349 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 944547008350 ligand binding site [chemical binding]; other site 944547008351 flexible hinge region; other site 944547008352 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 944547008353 putative switch regulator; other site 944547008354 non-specific DNA interactions [nucleotide binding]; other site 944547008355 DNA binding site [nucleotide binding] 944547008356 sequence specific DNA binding site [nucleotide binding]; other site 944547008357 putative cAMP binding site [chemical binding]; other site 944547008358 Nitrous oxide-stimulated promoter; Region: YgbA_NO; cl08119 944547008359 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 944547008360 ligand binding site [chemical binding]; other site 944547008361 active site 944547008362 UGI interface [polypeptide binding]; other site 944547008363 catalytic site [active] 944547008364 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 944547008365 Uncharacterized ALDH ( RL0313) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_RL0313; cd07148 944547008366 NAD(P) binding site [chemical binding]; other site 944547008367 catalytic residues [active] 944547008368 acetolactate synthase; Reviewed; Region: PRK08322 944547008369 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 944547008370 PYR/PP interface [polypeptide binding]; other site 944547008371 dimer interface [polypeptide binding]; other site 944547008372 TPP binding site [chemical binding]; other site 944547008373 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 944547008374 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 944547008375 TPP-binding site [chemical binding]; other site 944547008376 dimer interface [polypeptide binding]; other site 944547008377 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 944547008378 Repair protein; Region: Repair_PSII; cl01535 944547008379 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 944547008380 Repair protein; Region: Repair_PSII; pfam04536 944547008381 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 944547008382 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 944547008383 motif II; other site 944547008384 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 944547008385 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 944547008386 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 944547008387 MarR family; Region: MarR; pfam01047 944547008388 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 944547008389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 944547008390 putative substrate translocation pore; other site 944547008391 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 944547008392 NMT1/THI5 like; Region: NMT1; pfam09084 944547008393 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 944547008394 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 944547008395 substrate binding pocket [chemical binding]; other site 944547008396 membrane-bound complex binding site; other site 944547008397 hinge residues; other site 944547008398 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547008399 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944547008400 dimer interface [polypeptide binding]; other site 944547008401 phosphorylation site [posttranslational modification] 944547008402 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547008403 ATP binding site [chemical binding]; other site 944547008404 Mg2+ binding site [ion binding]; other site 944547008405 G-X-G motif; other site 944547008406 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547008407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547008408 active site 944547008409 phosphorylation site [posttranslational modification] 944547008410 intermolecular recognition site; other site 944547008411 dimerization interface [polypeptide binding]; other site 944547008412 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 944547008413 DNA binding site [nucleotide binding] 944547008414 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944547008415 dimer interface [polypeptide binding]; other site 944547008416 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 944547008417 putative CheW interface [polypeptide binding]; other site 944547008418 FIST N domain; Region: FIST; smart00897 944547008419 FIST C domain; Region: FIST_C; pfam10442 944547008420 PAS domain; Region: PAS_9; pfam13426 944547008421 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547008422 putative active site [active] 944547008423 heme pocket [chemical binding]; other site 944547008424 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944547008425 PAS domain; Region: PAS_9; pfam13426 944547008426 putative active site [active] 944547008427 heme pocket [chemical binding]; other site 944547008428 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 944547008429 Zn2+ binding site [ion binding]; other site 944547008430 Mg2+ binding site [ion binding]; other site 944547008431 Hemerythrin; Region: Hemerythrin; cd12107 944547008432 Fe binding site [ion binding]; other site 944547008433 Hemerythrin; Region: Hemerythrin; cd12107 944547008434 Fe binding site [ion binding]; other site 944547008435 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944547008436 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547008437 metal binding site [ion binding]; metal-binding site 944547008438 active site 944547008439 I-site; other site 944547008440 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 944547008441 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 944547008442 HlyD family secretion protein; Region: HlyD_3; pfam13437 944547008443 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 944547008444 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 944547008445 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 944547008446 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 944547008447 DNA binding residues [nucleotide binding] 944547008448 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 944547008449 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 944547008450 cofactor binding site; other site 944547008451 DNA binding site [nucleotide binding] 944547008452 substrate interaction site [chemical binding]; other site 944547008453 flavoprotein, HI0933 family; Region: TIGR00275 944547008454 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 944547008455 Walker A motif; other site 944547008456 ATP binding site [chemical binding]; other site 944547008457 Walker B motif; other site 944547008458 arginine finger; other site 944547008459 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 944547008460 VWA-like domain (DUF2201); Region: DUF2201; pfam09967 944547008461 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 944547008462 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 944547008463 active site 944547008464 metal binding site [ion binding]; metal-binding site 944547008465 Cupin domain; Region: Cupin_2; pfam07883 944547008466 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 944547008467 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 944547008468 homodimer interface [polypeptide binding]; other site 944547008469 substrate-cofactor binding pocket; other site 944547008470 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944547008471 catalytic residue [active] 944547008472 Predicted transcriptional regulator [Transcription]; Region: COG1959 944547008473 Transcriptional regulator; Region: Rrf2; pfam02082 944547008474 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 944547008475 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 944547008476 dimer interface [polypeptide binding]; other site 944547008477 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944547008478 catalytic residue [active] 944547008479 Predicted membrane protein (DUF2061); Region: DUF2061; cl01257 944547008480 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 944547008481 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 944547008482 Active Sites [active] 944547008483 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 944547008484 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 944547008485 Active Sites [active] 944547008486 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 944547008487 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 944547008488 CysD dimerization site [polypeptide binding]; other site 944547008489 G1 box; other site 944547008490 putative GEF interaction site [polypeptide binding]; other site 944547008491 GTP/Mg2+ binding site [chemical binding]; other site 944547008492 Switch I region; other site 944547008493 G2 box; other site 944547008494 G3 box; other site 944547008495 Switch II region; other site 944547008496 G4 box; other site 944547008497 G5 box; other site 944547008498 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 944547008499 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 944547008500 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 944547008501 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 944547008502 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 944547008503 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 944547008504 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 944547008505 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 944547008506 catalytic residue [active] 944547008507 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 944547008508 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 944547008509 putative active site [active] 944547008510 putative metal binding site [ion binding]; other site 944547008511 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 944547008512 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 944547008513 putative dimer interface [polypeptide binding]; other site 944547008514 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 944547008515 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 944547008516 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 944547008517 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 944547008518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 944547008519 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 944547008520 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 944547008521 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 944547008522 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 944547008523 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 944547008524 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 944547008525 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944547008526 dimer interface [polypeptide binding]; other site 944547008527 putative CheW interface [polypeptide binding]; other site 944547008528 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 944547008529 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 944547008530 Walker A/P-loop; other site 944547008531 ATP binding site [chemical binding]; other site 944547008532 Q-loop/lid; other site 944547008533 ABC transporter signature motif; other site 944547008534 Walker B; other site 944547008535 D-loop; other site 944547008536 H-loop/switch region; other site 944547008537 TOBE-like domain; Region: TOBE_3; pfam12857 944547008538 sulfate transport protein; Provisional; Region: cysT; CHL00187 944547008539 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 944547008540 dimer interface [polypeptide binding]; other site 944547008541 conserved gate region; other site 944547008542 putative PBP binding loops; other site 944547008543 ABC-ATPase subunit interface; other site 944547008544 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 944547008545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 944547008546 dimer interface [polypeptide binding]; other site 944547008547 conserved gate region; other site 944547008548 putative PBP binding loops; other site 944547008549 ABC-ATPase subunit interface; other site 944547008550 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944547008551 metal binding site [ion binding]; metal-binding site 944547008552 active site 944547008553 I-site; other site 944547008554 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 944547008555 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 944547008556 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 944547008557 Rrf2 family protein; Region: rrf2_super; TIGR00738 944547008558 Transcriptional regulator; Region: Rrf2; pfam02082 944547008559 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 944547008560 active site 944547008561 Zn binding site [ion binding]; other site 944547008562 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_3; cd06253 944547008563 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 944547008564 putative active site [active] 944547008565 Zn binding site [ion binding]; other site 944547008566 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 944547008567 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 944547008568 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 944547008569 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 944547008570 G1 box; other site 944547008571 putative GEF interaction site [polypeptide binding]; other site 944547008572 GTP/Mg2+ binding site [chemical binding]; other site 944547008573 Switch I region; other site 944547008574 G2 box; other site 944547008575 G3 box; other site 944547008576 Switch II region; other site 944547008577 G4 box; other site 944547008578 G5 box; other site 944547008579 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 944547008580 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 944547008581 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 944547008582 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 944547008583 Sulfatase; Region: Sulfatase; pfam00884 944547008584 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 944547008585 active site 944547008586 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 944547008587 Domain of unknown function (DUF1924); Region: DUF1924; pfam09086 944547008588 Dihaem cytochrome c; Region: DHC; pfam09626 944547008589 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 944547008590 Dihaem cytochrome c; Region: DHC; pfam09626 944547008591 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944547008592 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944547008593 active site 944547008594 phosphorylation site [posttranslational modification] 944547008595 intermolecular recognition site; other site 944547008596 dimerization interface [polypeptide binding]; other site 944547008597 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 944547008598 DNA binding site [nucleotide binding] 944547008599 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 944547008600 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944547008601 dimerization interface [polypeptide binding]; other site 944547008602 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944547008603 ATP binding site [chemical binding]; other site 944547008604 Mg2+ binding site [ion binding]; other site 944547008605 G-X-G motif; other site 944547008606 Methyltransferase domain; Region: Methyltransf_31; pfam13847 944547008607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944547008608 S-adenosylmethionine binding site [chemical binding]; other site 944547008609 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 944547008610 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 944547008611 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 944547008612 Zn2+ binding site [ion binding]; other site 944547008613 Mg2+ binding site [ion binding]; other site 944547008614 Thymidylate synthase complementing protein; Region: Thy1; cl03630 944547008615 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 944547008616 glutaminase; Provisional; Region: PRK00971 944547008617 Predicted membrane protein [Function unknown]; Region: COG2860 944547008618 UPF0126 domain; Region: UPF0126; pfam03458 944547008619 UPF0126 domain; Region: UPF0126; pfam03458 944547008620 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 944547008621 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 944547008622 active site 944547008623 substrate binding site [chemical binding]; other site 944547008624 cosubstrate binding site; other site 944547008625 catalytic site [active] 944547008626 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 944547008627 active site 944547008628 putative DNA-binding cleft [nucleotide binding]; other site 944547008629 dimer interface [polypeptide binding]; other site 944547008630 Replication protein; Region: Rep_1; cl02412