-- dump date 20140618_204239 -- class Genbank::CDS -- table cds_note -- id note YP_153445.1 hypothetical protein identified by Glimmer 2 YP_153446.1 COG0026 phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) YP_153447.1 conserved hypothetical protein similar to ZP_00211153.1 YP_153448.1 COG0772 FtsW bacterial cell division membrane protein; similar to NP_220664.1 YP_153449.1 conserved family - DNA binding protein YP_153450.1 conserved family - transcriptional regulator YP_153451.1 hypothetical protein identified by Glimmer 2 YP_153452.1 hypothetical protein identified by Glimmer 2 YP_153453.1 COG1181 D-alanine-D-alanine ligase and related ATP-grasp enzymes; open reading frame split domain with AM011 YP_153454.1 COG1181 D-alanine-D-alanine ligase and related ATP-grasp enzymes; open reading frame split domain with AM010 YP_153455.1 COG0180 trpS tryptophanyl-tRNA synthetase YP_153456.1 COG0576 GrpE molecular chaperone GrpE (heat shock protein) YP_153457.1 COG0117 RibD pyrimidine deaminase YP_153458.1 CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_153459.1 conserved hypothetical protein similar to ZP_00211144.1 YP_153460.1 hypothetical protein identified by Glimmer 2 YP_153461.1 COG0582 XerC integrase YP_153462.1 COG1136 PhnL ABC-type transport systems involved in lipoprotein release, ATPase components; similar to NP_102951.1 YP_153463.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate YP_153464.1 conserved family - exoprotein involved in heme utilization or adhesion YP_153465.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone YP_153466.1 hypothetical protein identified by Glimmer 2 YP_153467.1 other copies include: AM044, AM065, AM077, AM082 AM210, AM717, AM723, AM989, AM1061, AM1149 and AM1253; member of msp2 superfamily YP_153468.1 other copies include: AM046, AM063, AM721, AM990 AM1059 and AM1251; member of msp2 superfamily YP_153469.1 hypothetical protein identified by Glimmer 2 YP_153470.1 conserved hypothetical protein similar to ZP_00220026.1 YP_153471.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate YP_153472.1 hypothetical protein identified by Glimmer 2 YP_153473.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_153474.1 conserved hypothetical protein similar to ZP_00012590.1 YP_153475.1 conserved family - methyltransferase YP_153476.1 other copies include: AM030, AM065, AM077, AM082 AM210, AM717, AM723, AM989, AM1061, AM1149 and AM1253; member of msp2 superfamily YP_153477.1 other copies include: AM032, AM063, AM721, AM990 AM1059 and AM1251; member of msp2 superfamily YP_153478.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_153479.1 conserved hypothetical protein similar to ZP_00211121.1 YP_153480.1 COG0291 RpmI ribosomal protein L35 YP_153481.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_153482.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_153483.1 conserved family - dehydrogenase YP_153484.1 COG1207 GlmU N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase) YP_153485.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_153486.1 COG0477 ProP permeases of the major facilitator superfamily; similar to NP_359744.1 YP_153487.1 other copies include: AM032, AM046, AM721, AM990 AM1059 and AM1251; member of msp2 superfamily YP_153488.1 other copies include: AM030, AM044, AM077, AM082 AM210, AM717, AM723, AM989, AM1061, AM1149 and AM1253; member of msp2 superfamily YP_153490.1 conserved hypothetical protein similar to ZP_00211126.1 YP_153491.1 conserved hypothetical protein similar to NP_966764.1 YP_153492.1 hypothetical protein identified by Glimmer 2 YP_153493.1 conserved family - transcriptional regulator YP_153494.1 conserved family - ABC transporter YP_153495.1 member of msp2 superfamily YP_153496.1 other copies include: AM030, AM044, AM065, AM082 AM210, AM717, AM723, AM989, AM1061, AM1149 and AM1253; member of msp2 superfamily YP_153497.1 other copies include: AM030, AM044, AM065, AM077 AM210, AM717, AM723, AM989, AM1061, AM1149 and AM1253; member of msp2 superfamily YP_153498.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_153499.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_153500.1 COG0476 ThiF dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family YP_153501.1 similar to AAG34715.1; member of msp2 superfamily YP_153502.1 conserved hypothetical protein similar to NP_220824.1 YP_153503.1 conserved family - oxidoreductase YP_153504.1 hypothetical protein identified by Glimmer 2 YP_153505.1 COG0526 TrxA thiol-disulfide isomerase and thioredoxins YP_153508.1 conserved family - hydrolase YP_153509.1 COG0516 GuaB IMP dehydrogenase/GMP reductase YP_153510.1 catalyzes the phosphorylation of NAD to NADP YP_153511.2 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_153512.1 COG0331 FabD (ACP S-malonyltransferase); similar to NP_221088.1 YP_153513.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) YP_153514.1 conserved family - permease YP_153515.1 conserved hypothetical protein similar to ZP_00211094.1 YP_153516.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA YP_153517.1 conserved hypothetical protein similar to NP_966778.1 YP_153518.1 COG0612 PqqL predicted Zn-dependent peptidases; similar to NP_220605.1 YP_153519.1 conserved family - M23/M37 peptidase domain protein YP_153520.1 conserved family - dioxygenase YP_153521.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine YP_153522.1 hypothetical protein identified by Glimmer 2 YP_153523.1 member of msp1b gene family, full length gene 2 other copy is AM180; member of msp1 superfamily YP_153524.1 member of msp1b gene family, partial gene 2; member of msp1 superfamily YP_153525.1 COG1197 Mfd transcription-repair coupling factor - superfamily II helicase YP_153526.1 COG0328 RnhA ribonuclease HI; similar to NP_767956.1 YP_153527.1 conserved hypothetical protein similar to ZP_00211075.1 YP_153528.1 Catalyzes the phosphorylation of UMP to UDP YP_153529.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_153530.1 COG0020 UppS undecaprenyl pyrophosphate synthase YP_153531.1 COG0575 CdsA CDP-diglyceride synthetase YP_153532.1 member of msp1b gene family, partial gene 3; member of msp1 superfamily YP_153533.1 hypothetical protein identified by Glimmer 2 YP_153534.1 COG0152 PurC phosphoribosylaminoimidazole-succinocarboxamide (SAICAR) YP_153535.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_153536.1 conserved family - disulfide oxidoreductase YP_153537.1 COG3175 COX11 cytochrome oxidase assembly factor YP_153538.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate YP_153539.1 ATP-binding protein; required for proper cytochrome C maturation YP_153540.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_153541.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis YP_153542.1 conserved hypothetical protein similar to NP_966731.1 YP_153543.1 COG1278 CspC cold shock proteins YP_153544.1 COG0347 GlnK nitrogen regulatory protein PII; similar to NP_420550.1 YP_153545.1 COG0349 Rnd ribonuclease D; similar to NP_531848.1; other copies include: AM1015 YP_153546.1 COG0272 Lig NAD-dependent DNA ligase YP_153547.1 similar to NP_772351.1 YP_153548.1 conserved hypothetical protein similar to NP_966273.1 YP_153549.1 conserved family - thioredoxin YP_153550.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_153551.1 conserved family - TRAP-type uncharacterized transport system, fused permease YP_153552.1 conserved family - uncharacterized membrane protein, required for colicin V production YP_153553.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_153554.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_153555.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_153556.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_153557.1 conserved family - CyaY protein YP_153558.1 COG1132 MdlB ABC-type multidrug/protein/lipid transport system, ATPase component YP_153559.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol YP_153560.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase YP_153561.1 flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor YP_153562.1 bicyclomycin resistance protein; similar to NP_416687.1 YP_153563.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_153564.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_153565.1 COG0755 CcmC ABC-type transport system involved in cytochrome C biogenesis, permease component YP_153566.1 COG0194 Gmk guanylate kinase YP_153567.1 conserved hypothetical protein similar to NP_630160.1 YP_153568.1 COG0190 FolD 5,10-methylene-tetrahydrofolate dehydrogenase/methenyl tetrahydrofolate cyclohydrolase YP_153569.1 member of msp1b gene family, full length gene 1 other copy is AM123; member of msp1 superfamily YP_153570.1 hypothetical protein identified by Glimmer 2 YP_153571.1 member of msp1b gene family, partial gene 1; member of msp1 superfamily; similar to AAD20331.1 YP_153572.1 conserved family - hydrolase or acyltransferase YP_153573.1 COG3303 NrfA formate-dependent nitrite reductase, periplasmic cytochrome C552 subunit YP_153574.1 COG1009 NuoL NADH:ubiquinone oxidoreductase subunit 5 (chain L)/multisubunit Na+/H+ antiporter, MnhA; similar to NP_220667.1 YP_153575.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_153576.1 hypothetical protein identified by Glimmer 2 YP_153577.1 conserved family - phosphatase YP_153578.1 COG0173 AspS aspartyl-tRNA synthetase; open reading frame split domain with AM200 YP_153579.1 COG0173 AspS aspartyl-tRNA synthetase; open reading frame split domain with AM199 YP_153580.1 conserved hypothetical protein similar to NP_360175.1 YP_153581.1 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione YP_153582.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_153583.1 COG1589 FtsQ cell division septal protein YP_153584.1 COG3852 NtrB signal transduction histidine kinase, nitrogen specific; similar to AAL08835.1 YP_153585.1 other copies include: AM030, AM044, AM065, AM077 AM082, AM717, AM723, AM989, AM1061, AM1149 and AM1253; member of msp2 superfamily YP_153586.1 COG1249 Lpd dihydrolipoamide dehydrogenase/glutathione oxidoreductase; similar to EAA26057.1 YP_153587.1 hypothetical protein identified by Glimmer 2 YP_153588.1 conserved hypothetical protein similar to NP_966526.1 YP_153589.1 conserved hypothetical protein similar to ZP_00210423.1 YP_153590.1 conserved hypothetical protein similar to ZP_00210422.1 YP_153591.1 conserved family - metal-dependent hydrolase YP_153592.1 COG0174 GlnA glutamine synthase; other copies include: AM1206 YP_153593.1 COG0573 PstC ABC-type phosphate transport system, permease component; similar to NP_531125.1 YP_153594.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_153595.1 COG0074 SucD succinyl-CoA synthetase subunit alpha; similar to EAA25376.1 YP_153596.1 catalyzes the interconversion of succinyl-CoA and succinate YP_153597.2 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_153598.1 COG0226 ABC-type phosphate transport system periplasmic component YP_153599.1 similar to AAB02878.1 YP_153600.1 conserved family - 2-nitropropane dioxygenase YP_153601.1 COG3038 CybB cytochrome B561; similar to ZP_00011855.1 YP_153602.1 conserved family - ABC transporter permease protein YP_153603.1 COG1404 aprE subtilisin-like serine proteases; similar to EAA25533.1 YP_153604.1 conserved hypothetical protein similar to NP_966600.1 YP_153605.1 COG0771 MurD UDP-N-acetylmuramoylalanine-D-glutamate ligase YP_153606.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA YP_153607.1 conserved family - metallo-beta-lactamase YP_153608.1 hypothetical protein identified by Glimmer 2 YP_153609.1 conserved hypothetical protein similar to ZP_00210406.1 YP_153610.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_153611.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_153612.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_153613.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_153614.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_153615.1 COG0250 NusG transcription antiterminator YP_153616.1 binds directly to 23S ribosomal RNA YP_153617.2 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_153618.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_153619.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_153620.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_153621.1 COG0086 RpoC DNA-directed RNA polymerase beta subunit/160 kD subunit YP_153622.1 COG0164 RnhB ribonuclease HII YP_153623.1 hypothetical protein identified by Glimmer 2 YP_153624.1 conserved hypothetical protein similar to NP_965966.1 YP_153625.1 conserved family - 7-keto-8-aminopelargonate synthetase YP_153626.1 conserved family - Na+/H+ antiporter YP_153627.1 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP YP_153628.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors YP_153629.1 conserved family - N-formylmethionyl-tRNA deformylase YP_153630.1 conserved family - YP_153631.1 conserved hypothetical protein similar to ZP_00073278.1 YP_153632.1 COG0259 PdxH pyridoxamine phosphate oxidase YP_153633.1 COG0769 MurE UDP-N-acetylmuramyl tripeptide synthase YP_153634.1 hypothetical protein identified by Glimmer 2 YP_153635.1 COG0626 cystathionine beta-lyases/cystathionine gamma-synthases YP_153636.1 COG0271 BolA stress-induced morphogen (activity unknown) YP_153637.1 conserved hypothetical protein similar to ZP_00210378.1 YP_153638.1 COG0587 DnaE DNA polymerase III subunit alpha YP_153639.1 COG0128 AroA 5-enolpyruvylshikimate-3-phosphate synthase YP_153640.1 COG2009 SdhC succinate dehydrogenase/fumarate reductase cytochrome b subunit; similar to AAL60178.1 YP_153641.1 hypothetical protein identified by Glimmer 2 YP_153642.1 COG2142 SdhD succinate dehydrogenase hydrophobic anchor subunit YP_153643.1 similar to AAS89251.2 YP_153644.1 COG0351 ThiD hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; similar to NP_422017.1 YP_153645.1 conserved family - ATPase involved in DNA replication YP_153646.1 COG0628 PerM predicted permease; similar to NP_385291.1 YP_153647.1 conserved hypothetical protein similar to NP_966181.1 YP_153648.1 Binds directly to 16S rRNA where it nucleates assembly of the 30S subunit YP_153649.1 conserved hypothetical protein similar to ZP_00210366.1 YP_153650.1 conserved family - acetyltransferase YP_153651.1 COG1267 PgpA phosphatidlglycerophosphatase A YP_153652.1 hypothetical protein identified by Glimmer 2 YP_153653.1 COG0544 Tig FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor); similar to NP_420771.1 YP_153654.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_153655.1 binds and unfolds substrates as part of the ClpXP protease YP_153656.1 COG0466 Lon ATP-dependent Lon protease bacterial type YP_153657.1 COG0223 Fmt methionyl-tRNA formyltransferase YP_153658.1 conserved hypothetical protein similar to ZP_00210358.1 YP_153659.1 conserved hypothetical protein similar to NP_966137.1 YP_153660.1 COG0352 ThiE thiamine monophosphate synthase; similar to NP_229721.1 YP_153661.1 conserved hypothetical protein similar to ZP_00210354.1 YP_153662.1 conserved hypothetical protein similar to NP_965941.1 YP_153663.1 COG1674 FtsK DNA segregation ATPase FtsK/SpoIIIE and related proteins; similar to NP_533424.1 YP_153664.1 hypothetical protein identified by Glimmer 2 YP_153665.1 DapATase; functions in arginine biosynthetic pathway; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine YP_153666.1 COG0642 BaeS signal transduction histidine kinase; similar to NP_220615.1 YP_153667.1 conserved hypothetical protein similar to NP_966025.1 YP_153668.1 N: COG0848 ExbD biopolymer transport protein YP_153669.1 COG0811 TolQ biopolymer transport protein YP_153670.1 COG0323 MutL DNA mismatch repair enzyme (predicted ATPase); open reading frame split domain with AM333 YP_153671.1 COG0323 MutL DNA mismatch repair enzyme (predicted ATPase); open reading frame split domain with AM332 YP_153672.1 COG0758 Smf predicted Rossmann fold nucleotide-binding protein involved in DNA uptake YP_153673.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_153674.1 conserved family - twitching mobility protein YP_153675.1 COG0304 FabB 3-oxoacyl-(ACP synthase) YP_153676.1 COG0236 AcpP ACP; similar to NP_221115.1 YP_153677.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_153678.1 conserved hypothetical protein similar to NP_965975.1 YP_153679.1 conserved family - disulfide bond formation protein YP_153680.1 hypothetical protein identified by Glimmer 2 YP_153681.1 hypothetical protein identified by Glimmer 2 YP_153682.1 hypothetical protein identified by Glimmer 2 YP_153683.1 hypothetical protein identified by Glimmer 2 YP_153684.1 COG2941 CAT5 ubiquinone biosynthesis protein COQ7 YP_153685.1 hypothetical protein identified by Glimmer 2 YP_153686.1 hypothetical protein identified by Glimmer 2 YP_153687.1 hypothetical protein identified by Glimmer 2 YP_153688.1 hypothetical protein identified by Glimmer 2 YP_153689.1 hypothetical protein identified by Glimmer 2 YP_153690.1 hypothetical protein identified by Glimmer 2 YP_153691.1 hypothetical protein identified by Glimmer 2 YP_153692.1 hypothetical protein identified by Glimmer 2 YP_153693.1 COG0210 UvrD superfamily I DNA and RNA helicases YP_153694.1 hypothetical protein identified by Glimmer 2 YP_153695.1 negatively supercoils closed circular double-stranded DNA YP_153696.1 COG0177 Nth predicted EndoIII-related endonuclease YP_153697.1 hypothetical protein identified by Glimmer 2 YP_153698.1 molecular chaperone YP_153699.1 hypothetical protein identified by Glimmer 2 YP_153700.1 hypothetical protein identified by Glimmer 2 YP_153701.1 hypothetical protein identified by Glimmer 2 YP_153702.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_153703.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_153704.1 hypothetical protein identified by Glimmer 2 YP_153705.1 COG0340 BirA biotin-(acetyl-CoA carboxylase ligase) YP_153706.1 COG0625 Gst glutathione-S-transferases; similar to NP_360419.1 YP_153707.1 conserved hypothetical protein similar to BAA36355.1 YP_153708.1 conserved family - ABC transporter YP_153709.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_153710.1 hypothetical protein identified by Glimmer 2 YP_153711.1 COG0803 ZnuA ABC-type Mn/Zn transport system periplasmic Mn/Zn-binding (lipo)protein (surface adhesin); similar to NP_541155.1 YP_153712.1 COG1121 ZnuC ABC-type Mn/Zn transport systems ATPase component; similar to NP_759163.1 YP_153713.1 COG0543 UbiB 2-polyprenylphenol hydroxylase; similar to NP_541211.1 YP_153714.1 conserved hypothetical protein similar to ZP_00210709.1 YP_153715.1 conserved hypothetical protein similar to ZP_00142641.1 YP_153716.1 conserved hypothetical protein similar to ZP_00210707.1 YP_153717.1 conserved hypothetical protein similar to NP_966505.1 YP_153718.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide YP_153719.1 conserved family - phage major capsid protein YP_153720.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_153721.1 protein kinase C inhibitor 1 (pkcI ); similar to EAA25530.1 YP_153722.1 hypothetical protein identified by Glimmer 2 YP_153723.1 This protein performs the mismatch recognition step during the DNA repair process YP_153724.1 hypothetical protein identified by Glimmer 2 YP_153725.1 conserved family - sugar and other transporter; high sequence identity to AM415, may be a duplicate gene YP_153726.1 conserved family - sugar and other transporter; high sequence identity to AM414, may be a duplicate gene YP_153727.1 COG0171 NadE NAD synthase YP_153728.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_153729.1 COG0768 FtsI cell division protein FtsI/penicillin-binding protein 2 YP_153730.1 conserved hypothetical protein similar to ZP_00210697.1 YP_153731.1 conserved family - permease of the major facilitator superfamily YP_153732.1 COG0629 Ssb single-stranded DNA-binding protein; similar to NP_771338.1 YP_153734.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_153735.1 COG0623 FabI enoyl-[ACP] reductase (NADH); similar to NP_385004.1 YP_153736.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_153737.1 hypothetical protein identified by Glimmer 2 YP_153738.1 conserved family - nicotinic acid mononucleotide adenylyltransferase YP_153739.1 involved in the de novo synthesis of pyridoxine (Vitamin B6) YP_153740.1 conserved family - DNA polymerase III subunit YP_153741.1 conserved hypothetical protein similar to ZP_00210684.1 YP_153742.1 COG0237 CoaE dephospho-CoA kinase YP_153743.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine YP_153744.1 conserved hypothetical protein similar to ZP_00210681.1 YP_153745.1 COG1758 RpoZ DNA-directed RNA polymerase subunit K/omega YP_153746.1 conserved hypothetical protein similar to ZP_00210679.1 YP_153747.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_153748.1 conserved family - Mg-dependent DNase YP_153749.1 COG0284 PyrF orotidine-5'-phosphate decarboxylase YP_153750.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome C maturation system; periplasmic protein anchored to the inner membrane YP_153751.1 COG0496 SurE survival protein, predicted acid phosphatase YP_153752.1 COG0852 NuoC NADH:ubiquinone oxidoreductase 27 kD subunit YP_153753.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen YP_153754.1 COG0838 NuoA NADH:ubiquinone oxidoreductase subunit 3 (chain A) YP_153755.1 COG0178 UvrA excinuclease ATPase subunit YP_153756.1 COG0781 NusB transcription termination factor YP_153757.2 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_153758.2 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria YP_153759.1 COG1183 PssA phosphatidylserine synthase YP_153760.1 catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine YP_153761.1 conserved hypothetical protein similar to NP_840932.1 YP_153762.1 hypothetical protein identified by Glimmer 2 YP_153763.1 COG0707 MurG UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase; similar to NP_421354.1 YP_153764.1 COG0231 Efp translation elongation factor P; translation initiation factor eIF-5A YP_153765.1 COG0483 SuhB Archaeal fructose-1,6-bisphosphatase and related enzymes of; similar to NP_104922.1 YP_153766.1 COG0564 RluA pseudouridylate synthases, 23S RNA-specific YP_153767.1 involved in swarmer-to-stalked cell differentiation in Caulobacter crescentus; catalyzes the condensation of two GTP molecules to form the secondary messenger cyclic di-GMP (c-di-GMP); upon phosphorylation of domain D1 the protein dimerizes; presumably this allows the two GTP-bound GGDEF (diguanylate cyclase) domains to catalyze the condensation reaction; allosterically inhibited by c-di-GMP YP_153768.1 conserved hypothetical protein similar to ZP_00210656.1 YP_153769.1 conserved family - NAD-specific glutamate dehydrogenase YP_153770.1 conserved hypothetical protein similar to ZP_00210654.1 YP_153771.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_153772.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE YP_153773.1 conserved family - thiol:disulfide interchange protein YP_153774.1 conserved hypothetical protein similar to ZP_00210650.1 YP_153775.1 conserved hypothetical protein similar to ZP_00210648.1 YP_153776.1 COG0358 DnaG DNA primase (bacterial type); similar to NP_539447.1 YP_153777.1 hypothetical protein identified by Glimmer 2 YP_153778.1 COG0568 RpoD DNA-directed RNA polymerase sigma subunits (sigma70/sigma32) YP_153779.1 conserved family - nifR3 like protein YP_153780.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis YP_153781.1 hypothetical protein identified by Glimmer 2 YP_153782.1 COG1324 CutA uncharacterized protein involved in tolerance to divalent cations YP_153784.1 conserved family - O-methyltransferase YP_153785.1 conserved hypothetical protein similar to ZP_00210640.1 YP_153786.1 conserved family - predicted sugar kinase YP_153787.1 COG0550 TopA topoisomerase IA YP_153788.1 conserved hypothetical protein similar to ZP_00210636.1 YP_153789.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids YP_153790.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_153791.1 conserved hypothetical protein similar to NP_966301.1 YP_153792.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_153793.1 COG0492 TrxB thioredoxin reductase YP_153794.1 COG0450 AhpC peroxiredoxin; similar to NP_360088.1 YP_153795.1 COG0075 serine-pyruvate aminotransferase/archaeal aspartate aminotransferase; open reading frame split domain with AM515 YP_153796.1 COG0075 serine-pyruvate aminotransferase/archaeal aspartate aminotransferase; open reading frame split domain with AM514 YP_153797.1 conserved family - peptidyl-prolyl cis-trans isomerase D YP_153798.1 conserved hypothetical protein similar to NP_384508.1 YP_153799.1 conserved family - transporter protein YP_153800.1 conserved family - transporter protein YP_153801.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_153802.1 functions in MreBCD complex in some organisms YP_153803.1 COG0130 TruB pseudouridine synthase YP_153804.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_153805.1 COG0005 Pnp purine nucleoside phosphorylase; similar to NP_384350.1 YP_153806.1 conserved hypothetical protein similar to NP_419648.1 YP_153807.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_153808.1 hypothetical protein identified by Glimmer 2 YP_153809.1 member of msp1 superfamily YP_153813.1 hypothetical protein identified by Glimmer 2 YP_153814.1 hypothetical protein identified by Glimmer 2 YP_153815.1 hypothetical protein identified by Glimmer 2 YP_153816.1 hypothetical protein identified by Glimmer 2 YP_153817.1 hypothetical protein identified by Glimmer 2 YP_153818.1 hypothetical protein identified by Glimmer 2 YP_153819.1 hypothetical protein identified by Glimmer 2 YP_153820.1 hypothetical protein identified by Glimmer 2 YP_153821.1 hypothetical protein identified by Glimmer 2 YP_153822.1 COG0611 ThiL thiamine monophosphate kinase; similar to NP_439456.1 YP_153823.1 conserved family - ribonuclease BN YP_153824.1 COG0161 adenosylmethionine-8-amino-7-oxononanoate; similar to ZP_00210585.1 YP_153825.1 conserved hypothetical protein similar to ZP_00210612.1 YP_153826.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_153827.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate YP_153828.1 conserved family - cell surface protein YP_153829.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_153830.1 conserved family - predicted membrane YP_153831.1 COG1539 FolB dihydroneopterin aldolase YP_153832.1 Catalyzes the reversible oxidation of malate to oxaloacetate YP_153833.1 Involved in ubiquinone biosynthesis YP_153834.1 COG0532 translation initiation factor 2 (GTPase) YP_153835.1 hypothetical protein identified by Glimmer 2 YP_153836.1 COG0698 ribose 5-phosphate isomerase; similar to ZP_00210562.1 YP_153837.1 Involved in ubiquinone biosynthesis YP_153838.1 similar to NP_533316.1 YP_153839.1 conserved hypothetical protein similar to AAL08810.1 YP_153840.1 conserved hypothetical protein similar to ZP_00210584.1 YP_153841.1 conserved hypothetical protein similar to ZP_00210584.1 YP_153842.1 hypothetical protein identified by Glimmer 2 YP_153843.1 conserved hypothetical protein similar to ZP_00210581.1 YP_153844.1 hypothetical protein identified by Glimmer 2 YP_153845.1 conserved hypothetical protein similar to ZP_00210579.1 YP_153846.1 hypothetical protein identified by Glimmer 2 YP_153847.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichia coli this protein self regulates transcription via a DNA-binding domain at the N-terminus but the proteins from this group do not and in addition appear to have a truncated C-terminal domain YP_153848.1 COG1028 FabG dehydrogenases with different specificities (related to short-chain alcohol); similar to NP_360820.1 YP_153849.1 conserved family - proline dehydrogenase YP_153850.1 hypothetical protein identified by Glimmer 2 YP_153851.1 COG0797 RlpA lipoproteins; similar to NP_220771.1 YP_153852.1 COG0708 XthA exonuclease III; similar to NP_360665.1 YP_153853.1 hypothetical protein identified by Glimmer 2 YP_153854.1 COG0257 RpmJ ribosomal protein L36 YP_153855.1 hypothetical protein identified by Glimmer 2 YP_153856.1 hypothetical protein identified by Glimmer 2 YP_153857.1 involved in the peptidyltransferase reaction during translation YP_153858.2 COG0261 RplU ribosomal protein L21 YP_153859.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_153860.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_153861.1 hypothetical protein identified by Glimmer 2 YP_153862.1 S-adenosyl-methyltransferase; similar to NP_773250.1 YP_153863.1 COG0212 5-formyltetrahydrofolate cyclo-ligase; similar to ZP_00210813.1 YP_153864.1 hypothetical protein identified by Glimmer 2 YP_153865.1 hypothetical protein identified by Glimmer 2 YP_153866.1 hypothetical protein identified by Glimmer 2 YP_153867.1 hypothetical protein identified by Glimmer 2 YP_153868.1 COG0492 TrxB thioredoxin reductase; similar to NP_360274.1 YP_153869.1 COG0312 TldD predicted Zn-dependent proteases and their inactivated homologs; similar to NP_774159.1 YP_153870.1 COG0302 FolE GTP cyclohydrolase I YP_153871.1 COG0224 AtpG F0F1-type ATP synthase subunit gamma YP_153872.1 Catalyzes the transfer of electrons from NADH to quinone YP_153873.1 Catalyzes the transfer of electrons from NADH to quinone YP_153874.1 COG0847 DnaQ DNA polymerase III epsilon subunit and related 3'-5' exonucleases; similar to NP_418825.1 YP_153875.1 conserved hypothetical protein similar to NP_966479.1 YP_153876.1 hypothetical protein identified by Glimmer 2 YP_153877.1 hypothetical protein identified by Glimmer 2 YP_153878.1 conserved hypothetical protein similar to NP_966787.1 YP_153879.1 COG0568 RpoD DNA-directed RNA polymerase sigma subunits (sigma70/sigma32); similar to NP_421892.1 YP_153880.1 conserved hypothetical protein similar to ZP_00210576.1 YP_153881.1 hypothetical protein identified by Glimmer 2 YP_153882.1 hypothetical protein identified by Glimmer 2 YP_153883.1 Catalyzes the transfer of electrons from NADH to quinone YP_153884.1 Catalyzes the transfer of electrons from NADH to quinone YP_153885.1 conserved hypothetical protein similar to ZP_00210543.1 YP_153886.1 COG0187 GyrB DNA gyrase (topoisomerase II) B subunit YP_153887.1 COG0163 UbiX 3-polyprenyl-4-hydroxybenzoate decarboxylase; similar to NP_360438.1 YP_153888.1 conserved hypothetical protein similar to ZP_00210560.1 YP_153889.1 hypothetical protein identified by Glimmer 2 YP_153890.1 COG0633 Fdx ferredoxin; similar to NP_220587.1 YP_153891.1 COG0443 DnaK molecular chaperone YP_153892.1 COG1076 DjlA DnaJ-domain-containing proteins 1; similar to NP_359900.1 YP_153893.1 COG0822 IscU NifU homologs involved in Fe-S cluster formation YP_153894.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis YP_153895.1 conserved family - aminotransferase YP_153896.1 conserved family - hydrolase YP_153897.1 class I; LysRS1; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri this enzyme charges both tRNA molecules for lysine that exist in this organism (but the tRNALysUUU very poorly) and in the presence of LysRS2 can charge tRNAPyl with lysine YP_153898.1 conserved hypothetical protein similar to ZP_00210549.1 YP_153899.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_153900.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_153901.1 similar to novel fructose-6-phosphate aldolase from Escherichia coli; enzyme from Methanocaldococcus janaschii shows transaldolase activity YP_153902.1 COG0355 AtpC F0F1-type ATP synthase epsilon subunit (mitochondrial delta subunit) YP_153903.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The subunit beta is a regulatory subunit YP_153904.1 COG2239 MgtE Mg/Co/Ni transporter MgtE (contains CBS domain) YP_153905.1 COG0293 FtsJ methyltransferase involved in cell division; similar to NP_108462.1 YP_153906.1 hypothetical protein identified by Glimmer 2 YP_153907.1 hypothetical protein identified by Glimmer 2 YP_153908.1 hypothetical protein identified by Glimmer 2 YP_153909.1 hypothetical protein identified by Glimmer 2 YP_153910.1 hypothetical protein identified by Glimmer 2 YP_153911.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_153912.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA YP_153913.1 hypothetical protein identified by Glimmer 2 YP_153914.1 hypothetical protein identified by Glimmer 2 YP_153915.1 hypothetical protein identified by Glimmer 2 YP_153916.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin) YP_153917.1 conserved hypothetical protein similar to NP_966995.1 YP_153918.2 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_153919.1 hypothetical protein identified by Glimmer 2 YP_153920.1 hypothetical protein identified by Glimmer 2 YP_153921.1 COG1186 PrfB protein chain release factor B; similar to NP_420681.1 YP_153922.1 conserved hypothetical protein similar to NP_966267.1 YP_153923.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_153924.1 COG0285 FolC folylpolyglutamate synthase; similar to NP_360416.1 YP_153925.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis YP_153926.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_153927.1 COG0666 Arp ankyrin repeat proteins; similar to AAP34825.1 YP_153928.1 Catalyzes the transfer of electrons from NADH to quinone YP_153929.1 COG0681 LepB signal peptidase I; similar to AAD02938.1 YP_153930.1 conserved hypothetical protein similar to ZP_00210598.1 YP_153931.1 hypothetical protein identified by Glimmer 2 YP_153932.1 hypothetical protein identified by Glimmer 2 YP_153933.1 other copies include: AM030, AM044, AM065, AM077 AM082, AM210, AM723, AM989, AM1061, AM1149 and AM1253; member of msp2 superfamily YP_153934.1 other copies include: AM032, AM046, AM063, AM990 AM1059 and AM1251; member of msp2 superfamily YP_153935.1 other copies include: AM030, AM044, AM065, AM077 AM082, AM210, AM717, AM989, AM1061, AM1149 and AM1253; member of msp2 superfamily YP_153936.1 COG1217 TypA predicted membrane GTPase involved in stress response; similar to NP_359986.1 YP_153937.1 COG0542 ClpA ATPases with chaperone activity ATP-binding subunit YP_153938.1 COG0861 membrane protein TerC, possibly involved in tellurium resistance YP_153939.1 COG0858 RbfA ribosome-binding factor A YP_153940.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_153941.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_153942.1 COG0841 AcrB cation/multidrug efflux pump; similar to NP_220560.1 YP_153943.1 COG0805 TatC Sec-independent protein secretion pathway component TatC YP_153944.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis YP_153945.1 hypothetical protein identified by Glimmer 2 YP_153946.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate YP_153947.1 COG1007 NuoN NADH:ubiquinone oxidoreductase subunit 2 (chain N); similar to NP_540062.1 YP_153948.1 COG1008 NuoM NADH:ubiquinone oxidoreductase subunit 4 (chain M); similar to NP_540063.1 YP_153949.1 COG1009 NuoL NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA; similar to NP_697827.1 YP_153950.1 COG0713 NuoK NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K); similar to NP_221141.1 YP_153951.1 COG0839 NuoJ NADH:ubiquinone oxidoreductase subunit 6 (chain J); similar to NP_771548.1 YP_153952.1 part of NADH-ubiquinone oxidoreductase complex I; shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase YP_153953.1 COG1250 FadB 3-hydroxyacyl-CoA dehydrogenase; similar to NP_220931.1 YP_153954.1 conserved hypothetical protein similar to ZP_00210777.1 YP_153955.1 COG0324 MiaA tRNA delta(2)-isopentenylpyrophosphate transferase YP_153956.1 conserved family - type IV secretory pathway, component VirB8 YP_153957.1 conserved family - RmuC recombination protein YP_153958.2 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_153959.1 hypothetical protein identified by Glimmer 2 YP_153960.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis YP_153961.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate YP_153962.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential YP_153963.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_153964.1 similar to NP_220986.1 YP_153965.1 COG0266 Nei formamidopyrimidine-DNA glycosylase YP_153966.1 hypothetical protein identified by Glimmer 2 YP_153967.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_153968.1 hypothetical protein identified by Glimmer 2 YP_153969.1 conserved hypothetical protein similar to NP_966502.1 YP_153970.1 conserved hypothetical protein similar to ZP_00210829.1 YP_153971.1 conserved hypothetical protein similar to NP_966502.1 YP_153972.1 COG2857 CYT1 cytochrome C1; similar to EAA25591.1 YP_153973.1 COG3658 - cytochrome b YP_153974.1 COG0723 QcrA Rieske Fe-S protein; similar to EAA25593.1 YP_153975.1 hypothetical protein identified by Glimmer 2 YP_153976.1 COG1108 ZnuB ABC-type Mn2+/Zn2+ transport systems, permease components; similar to NP_700279.1 YP_153977.1 hypothetical protein identified by Glimmer 2 YP_153978.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_153979.2 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_153980.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell YP_153981.1 COG0424 Maf nucleotide-binding protein implicated in inhibition of septum formation; similar to NP_683835.1 YP_153982.1 conserved hypothetical protein similar to ZP_00210840.1 YP_153983.1 COG1249 Lpd dihydrolipoamide dehydrogenase/glutathione oxidoreductase and related YP_153984.1 conserved hypothetical protein similar to ZP_00210842.1 YP_153985.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_153986.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate YP_153987.2 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_153988.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway YP_153989.1 COG0756 Dut dUTPase YP_153990.1 COG0770 MurF UDP-N-acetylmuramyl pentapeptide synthase YP_153991.1 conserved hypothetical protein similar to ZP_00210848.1 YP_153992.1 conserved hypothetical protein similar to ZP_00142380.1 YP_153993.1 conserved family - virB6 membrane component YP_153994.1 conserved family - virB6 membrane component YP_153995.1 COG3704 VirB6 type IV secretory pathway, VirB6 components YP_153996.1 COG3451 VirB4 type IV secretory pathway, VirB4 components; similar to AAM00407.1; other copies include: AM1053 YP_153997.1 COG3702 VirB3 type IV secretory pathway, VirB3 components YP_153998.1 COG0605 SodA superoxide dismutase YP_153999.1 COG0581 PstA ABC-type phosphate transport system, permease component; similar to AAM00409.1 YP_154001.1 catalyzes the radical-mediated insertion of two sulfur atoms into an ACP ACP bound to an octanoyl group to produce a lipoyl group YP_154002.1 hypothetical protein identified by Glimmer 2 YP_154003.1 hypothetical protein identified by Glimmer 2 YP_154004.1 COG1038 PycA pyruvate carboxylase, C-terminal domain/subunit YP_154005.1 COG0564 RluA pseudouridylate synthases, 23S RNA-specific; similar to EAA25988.1 YP_154006.1 required for 70S ribosome assembly YP_154007.1 COG1198 PriA primosomal protein N' (replication factor Y) - superfamily II helicase; similar to NP_360437.1 YP_154008.1 conserved hypothetical protein similar to NP_966301.1 YP_154009.1 conserved family - uroporphyrinogen-III synthase YP_154010.1 conserved family - aminopeptidase P YP_154011.1 conserved hypothetical protein similar to NP_966046.1 YP_154012.1 conserved hypothetical protein similar to NP_966501.1 YP_154013.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_154014.1 COG0541 Ffh signal recognition particle GTPase YP_154015.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone YP_154016.1 conserved family - oligoketide YP_154017.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_154018.1 COG1530 CafA ribonucleases G and E; similar to NP_220641.1 YP_154019.1 subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_154020.1 subunit B of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_154021.1 subunit B of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_154022.1 subunit G of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_154023.1 subunit F of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_154024.1 COG0021 TktA transketolase; similar to NP_698711.1 YP_154025.1 conserved family - carboxypeptidase YP_154026.1 conserved family - peptidoglycan-associated lipoprotein YP_154027.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_154028.1 conserved family - GTP-binding protein YP_154029.1 conserved hypothetical protein similar to NP_965963.1 YP_154030.1 Catalyzes the rate-limiting step in dNTP synthesis YP_154031.1 COG0142 IspA geranylgeranyl pyrophosphate synthase; similar to NP_104814.1 YP_154032.1 conserved hypothetical protein similar to NP_966903.1 YP_154033.1 similar to NP_819373.1 YP_154034.1 unwinds double stranded DNA YP_154035.1 conserved hypothetical protein similar to ZP_00210892.1 YP_154036.1 COG0402 SsnA cytosine deaminase and related metal-dependent hydrolases; similar to NP_542018.1 YP_154037.1 COG0332 FabH 3-oxoacyl-[ACP synthase III; similar to NP_420182.1 YP_154038.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY YP_154039.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_154040.1 COG0343 Tgt queuine/archaeosine tRNA-ribosyltransferase YP_154041.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_154042.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_154043.1 conserved hypothetical protein similar to ZP_00142335.1 YP_154044.1 UbiA prenyltransferase family catalyzes the transfer of a prenyl group to various acceptors with hydrophobic ring structures in the biosynthesis of respiratory quinones, hemes, chlorophylls, vitamin E, and shikonin YP_154045.1 experimental evidence exists for the production and secretion of this gene product YP_154046.1 hypothetical protein identified by Glimmer 2 YP_154047.1 hypothetical protein identified by Glimmer 2 YP_154048.1 in Escherichia coli transcription of this gene is enhanced by polyamines YP_154049.1 conserved hypothetical protein similar to ZP_00210903.1 YP_154050.1 conserved family - Na+/alanine symporter YP_154051.1 conserved hypothetical protein similar to ZP_00210905.1 YP_154052.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_154053.1 is a component of the macrolide binding site in the peptidyl transferase center YP_154054.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the subunit alpha is the first step in the sequential assembly of subunits to form the holoenzyme YP_154055.2 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_154056.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_154057.1 COG0563 Adk adenylate kinase and related kinases YP_154058.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_154059.1 late assembly protein YP_154060.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_154061.1 binds 5S rRNA along with protein L5 and L25 YP_154062.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_154063.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_154064.1 COG0199 RpsN ribosomal protein S14 YP_154065.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_154066.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_154067.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_154068.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_154069.1 one of the stabilizing components for the large ribosomal subunit YP_154070.2 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_154071.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_154072.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_154073.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_154074.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_154075.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_154076.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_154077.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_154078.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex YP_154079.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_154080.1 conserved family - tRNA/rRNA methyltransferase YP_154081.1 COG0283 Cmk cytidylate kinase YP_154082.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_154083.1 COG0616 SppA periplasmic serine proteases (ClpP class); similar to NP_104359.1 YP_154084.1 hypothetical protein identified by Glimmer 2 YP_154085.1 hypothetical protein identified by Glimmer 2 YP_154086.1 hypothetical protein identified by Glimmer 2 YP_154087.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic YP_154088.1 conserved family - ATPase YP_154089.1 conserved hypothetical protein similar to ZP_00210943.1 YP_154090.1 COG0330 HflC membrane protease subunits stomatin/prohibitin homologs; similar to NP_815489.1; second copy is ORF AM1064 YP_154091.1 hypothetical protein identified by Glimmer 2 YP_154092.1 conserved family - ATP-dependent nuclease YP_154093.1 COG0604 Qor NADPH:quinone reductase and related Zn-dependent oxidoreductases; similar to NP_102293.1 YP_154094.1 conserved family - alkaline protease secretion ATP-binding protein YP_154095.1 COG0294 FolP dihydropteroate synthase and related enzymes; similar to NP_279484.1 YP_154096.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_154097.1 hypothetical protein identified by Glimmer 2 YP_154098.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_154099.1 conserved family - pantothenate metabolism flavoprotein YP_154100.1 dihydroorotase and related cyclic amidohydrolases; similar to ZP_00210957.1 YP_154101.1 COG1109 CpsG phosphomannomutase; similar to NP_698675.1 YP_154102.1 lipoyl-[acyl-carrier protein]-protein-N-lipoyltransferse; lipoate-protein ligase B; transfers lipoate to apolipoproteins; involved in lipoate metabolism YP_154103.1 COG2003 RadC DNA repair proteins YP_154104.2 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_154105.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_154106.1 conserved family - oxidoreductase short-chain dehydrogenase YP_154107.1 COG0542 ATPases with chaperone activity ATP-binding subunit YP_154108.1 hypothetical protein identified by Glimmer 2 YP_154109.1 hypothetical protein identified by Glimmer 2 YP_154110.1 conserved family - dioxygenase YP_154111.1 hypothetical protein identified by Glimmer 2 YP_154112.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides YP_154113.1 conserved family - phosphoribosylglycinamide formyltransferase YP_154114.1 hypothetical protein identified by Glimmer 2 YP_154115.1 COG0046 PurL phosphoribosylformylglycinamidine (synthase, synthetase domain; similar to NP_868461.1 YP_154116.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_154117.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese YP_154118.1 conserved hypothetical protein similar to NP_252313.1 YP_154119.1 conserved hypothetical protein similar to ZP_00210971.1 YP_154120.1 hypothetical protein identified by Glimmer 2 YP_154121.1 COG0502 BioB biotin synthase and related enzymes; similar to NP_415296.1 YP_154122.1 COG0046 PurL phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain YP_154123.1 hypothetical protein identified by Glimmer 2 YP_154124.1 conserved family - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase YP_154125.1 hypothetical protein identified by Glimmer 2 YP_154126.1 conserved hypothetical protein similar to ZP_00210976.1 YP_154127.1 conserved hypothetical protein similar to NP_420685.1 YP_154128.1 conserved family - uncharacterized homolog of plant Iojap protein YP_154129.1 conserved hypothetical protein similar to NP_965909.1 YP_154130.1 conserved hypothetical protein similar to NP_966750.1 YP_154131.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_154132.1 COG0582 XerC integrase; similar to NP_698893.1 YP_154133.1 COG0240 GpsA glycerol 3-phosphate dehydrogenase YP_154134.1 member of msp2 superfamily YP_154135.1 other copies include: AM030, AM044, AM065, AM077 AM082, AM210, AM717, AM723, AM1061, AM1149 and AM1253; member of msp2 superfamily YP_154136.1 other copies include: AM032, AM046, AM063, AM721 AM1059 and AM1251; member of msp2 superfamily YP_154137.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_154138.1 hypothetical protein identified by Glimmer 2 YP_154139.1 heat shock protein involved in degradation of misfolded proteins YP_154140.1 heat shock protein involved in degradation of misfolded proteins YP_154141.1 COG2226 UbiE methylase involved in ubiquinone/menaquinone biosynthesis; similar to NP_700228.1 YP_154142.1 COG0143 MetG methionyl-tRNA synthetase; similar to NP_360683.1 YP_154143.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation. YP_154144.1 hypothetical protein identified by Glimmer 2 YP_154145.1 COG1622 CyoA Heme/copper-type cytochrome/quinol oxidases, subunit 2 YP_154146.1 COG0843 CyoB Heme/copper-type cytochrome/quinol oxidases, subunit 1 YP_154147.1 converts protoheme IX and farnesyl diphosphate to heme O YP_154148.1 conserved family - DNA uptake lipoprotein YP_154149.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_154150.1 COG1862 YajC preprotein translocase subunit YajC YP_154151.1 COG0449 GlmS glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar; similar to NP_771247.1 YP_154152.1 COG0592 DnaN DNA polymerase sliding clamp subunit (PCNA homolog) YP_154153.1 COG0349 Rnd ribonuclease D; other copies include: AM151 YP_154154.1 COG0745 OmpR response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding YP_154155.1 conserved family - transcriptional regulator YP_154156.1 COG0221 Ppa inorganic pyrophosphatase YP_154157.1 hypothetical protein identified by Glimmer 2 YP_154158.1 forms a direct contact with the tRNA during translation YP_154159.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_154160.1 COG1538 TolC outer membrane protein YP_154161.1 conserved hypothetical protein similar to NP_965897.1 YP_154162.1 conserved family - ATPase involved in chromosome partitioning YP_154163.1 COG0462 PrsA phosphoribosylpyrophosphate synthetase; similar to NP_797118.1 YP_154164.1 hypothetical protein identified by Glimmer 2 YP_154165.2 Catalyzes the conversion of citrate to isocitrate YP_154166.1 protein associated with Co2+ and Mg2+ efflux YP_154167.1 COG0026 PurK phosphoribosylaminoimidazole carboxylase (NCAIR synthetase); similar to NP_830163.1 YP_154168.1 hypothetical protein identified by Glimmer 2 YP_154169.1 hypothetical protein identified by Glimmer 2 YP_154170.1 hypothetical protein identified by Glimmer 2 YP_154171.1 hypothetical protein identified by Glimmer 2 YP_154172.1 hypothetical protein identified by Glimmer 2 YP_154173.1 conserved hypothetical protein similar to ZP_00210463.1 YP_154174.1 COG3451 VirB4 type IV secretory pathway, VirB4 components; other copies include: AM814 YP_154175.1 hypothetical protein identified by Glimmer 2; identity to Anaplasma (AAO41098.1) - but not the same as hypothetical protein YP_154176.1 conserved hypothetical protein similar to NP_966415.1; identity to Anaplasma (AAO41098.1) but not the same as hypothetical protein YP_154177.1 conserved hypothetical protein similar to ZP_00210466.1; identity to Anaplasma (AAO41095.1) but not the same as hypothetical protein YP_154178.1 hypothetical protein identified by Glimmer 2 YP_154179.1 hypothetical protein identified by Glimmer 2 YP_154180.1 other copies include: AM032, AM046, AM063, AM721 AM990 and AM1251; member of msp2 superfamily YP_154181.1 other copies include: AM030, AM044, AM065, AM077 AM082, AM210, AM717, AM723, AM989, AM1149 and AM1253; member of msp2 superfamily YP_154182.1 similar to AAN05084.1; member of msp2 superfamily; msp3 expression site YP_154183.1 COG0330 HflC membrane protease subunits stomatin/prohibitin homologs; similar to NP_220514.1; other copies include: AM925 YP_154184.1 COG0330 HflC membrane protease subunits stomatin/prohibitin homologs; similar to NP_220515.1 YP_154185.1 conserved family - serine protease YP_154186.1 conserved hypothetical protein similar to ZP_00210471.1 YP_154187.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity YP_154188.1 involved in the insertion of copper into subunit I of cytochrome C oxidase YP_154189.1 hypothetical protein identified by Glimmer 2 YP_154190.1 similar to AAP34273.1 YP_154191.1 hypothetical protein identified by Glimmer 2 YP_154192.1 hypothetical protein identified by Glimmer 2 YP_154193.1 conserved family - protease YP_154194.1 conserved family - protease YP_154195.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_154196.1 COG0196 RibF FAD synthase YP_154197.1 COG0695 GrxC glutaredoxin and related proteins YP_154198.1 COG2890 HemK predicted rRNA or tRNA methylase YP_154199.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn YP_154200.1 COG0508 AceF dihydrolipoamide acyltransferases YP_154201.1 conserved hypothetical protein similar to ZP_00053362.1 YP_154202.1 COG0414 PanC pantothenate synthetase YP_154203.1 conserved family - D-alanyl-D-alanine carboxypeptidasecarboxylpeptidase YP_154204.1 COG0526 TrxA thiol-disulfide isomerase and thioredoxins YP_154205.1 conserved hypothetical protein similar to NP_966808.1 YP_154206.1 conserved family - metallopeptidase YP_154207.1 COG4775 - outer membrane protein/protective antigen OMA87; similar to NP_359839.1 YP_154208.1 conserved family - outer membrane protein YP_154209.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP YP_154210.1 COG0138 PurH AICAR transformylase/IMP cyclohydrolase PurH; similar to NP_767221.1 YP_154211.1 COG0558 PgsA phosphatidylglycerophosphate synthase YP_154212.1 conserved hypothetical protein similar to NP_220763.1 YP_154213.1 COG0741 MltE soluble lytic murein transglycosylase and related regulatory proteins (some) YP_154214.1 COG3346 - uncharacterized conserved protein; similar to NP_360750.1 YP_154215.1 conserved hypothetical protein similar to NP_220935.1 YP_154216.1 conserved family - dehydrogenase YP_154217.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_154218.1 hypothetical protein identified by Glimmer 2 YP_154219.2 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 YP_154220.1 conserved hypothetical protein similar to ZP_00210501.1 YP_154221.1 conserved hypothetical protein similar to ZP_00210502.1 YP_154222.1 COG0849 FtsA predicted ATPases of the HSP70 class involved in cell division YP_154223.1 COG0168 TrkG Trk-type K+ transport systems membrane components; similar to NP_791626.1 YP_154224.1 COG0037 MesJ predicted ATPase of the PP-loop superfamily implicated in cell cycle control; similar to NP_220436.1 YP_154225.1 COG0465 HflB ATP-dependent Zn proteases YP_154226.2 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_154227.1 hypothetical protein identified by Glimmer 2 YP_154228.1 conserved hypothetical protein similar to NP_966776.1 YP_154229.1 COG1230 CzcD Co/Zn/Cd efflux system component; similar to NP_692320.1 YP_154230.1 COG2386 CcmB ABC-type transport system involved in cytochrome C biogenesis, permease component YP_154231.1 COG1734 DksA DnaK suppressor protein YP_154232.1 COG0132 BioD dethiobiotin synthetase YP_154233.1 COG0552 FtsY signal recognition particle GTPase; similar to NP_221126.1 YP_154234.1 catalyzes the formation of 2-oxoglutarate from isocitrate YP_154235.1 COG0608 RecJ single-stranded DNA-specific exonuclease; similar to NP_220901.1 YP_154236.1 hypothetical protein identified by Glimmer 2 YP_154237.1 COG0617 PcnB tRNA nucleotidyltransferase/poly(A) polymerase; similar to NP_220410.1 YP_154238.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate YP_154239.1 similar to AAN08687.1 YP_154240.1 member of msp2 superfamily YP_154241.1 member of msp2 superfamily YP_154242.1 hypothetical protein identified by Glimmer 2; known not to be transcribed YP_154243.1 member of msp2 superfamily YP_154244.1 member of msp2 superfamily YP_154245.1 similar to AAG31570.1; member of msp2 superfamily YP_154246.1 conserved family - DnaJ domain protein YP_154247.1 conserved family - nifU-like protein YP_154248.1 other copies include: AM030, AM044, AM065, AM077 AM082, AM210, AM717, AM723, AM989, AM1061 and AM1253; member of msp2 superfamily YP_154249.1 member of msp2 superfamily YP_154250.1 member of msp2 superfamily YP_154251.1 hypothetical protein identified by Glimmer 2 YP_154252.1 member of msp2 superfamily YP_154253.1 hypothetical protein identified by Glimmer 2 YP_154254.1 member of msp2 superfamily YP_154255.1 conserved hypothetical protein similar to NP_220844.1 YP_154256.1 COG1138 CcmF cytochrome C biogenesis factor YP_154257.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_154258.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_154259.1 COG0807 RibA GTP cyclohydrolase II; other copies include AM120 and AM1317 YP_154260.1 COG0782 GreA transcription elongation factor YP_154261.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_154262.1 COG0712 AtpH F0F1-type ATP synthase delta subunit (mitochondrial oligomycin sensitivity protein) YP_154263.1 conserved hypothetical protein similar to ZP_00211180.1 YP_154264.1 conserved hypothetical protein similar to NP_966944.1 YP_154265.1 conserved hypothetical protein similar to ZP_00211182.1 YP_154266.1 conserved family - ABC-transporter YP_154267.1 conserved hypothetical protein similar to NP_966159.1 YP_154268.1 conserved hypothetical protein similar to ZP_00211185.1 YP_154269.1 COG0372 GltA citrate synthase YP_154270.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_154271.1 hypothetical protein identified by Glimmer 2 YP_154272.1 hypothetical protein identified by Glimmer 2 YP_154273.1 COG0508 AceF dihydrolipoamide acyltransferases YP_154274.1 hypothetical protein identified by Glimmer 2 YP_154275.2 catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate YP_154276.1 COG0768 FtsI cell division protein FtsI/penicillin-binding protein 2 YP_154277.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_154278.1 conserved hypothetical protein similar to ZP_00211205.1 YP_154279.1 catalyzes the formation of 5-aminolevulinate from succinyl-CoA and glycine YP_154280.1 COG0162 TyrS tyrosyl-tRNA synthetase YP_154281.1 COG0174 GlnA glutamine synthase; other copies include: AM222 YP_154282.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_154283.1 COG0142 IspA geranylgeranyl pyrophosphate synthase YP_154284.1 hypothetical protein identified by Glimmer 2 YP_154285.1 similar to NP_220490.1 YP_154286.1 conserved family - ABC-type transport protein YP_154287.1 COG0036 Rpe pentose-5-phosphate-3-epimerase; similar to EAA23792.1 YP_154288.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair YP_154289.1 hypothetical protein identified by Glimmer 2 YP_154290.1 COG0078 ArgF ornithine carbamoyltransferase YP_154291.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_154292.1 member of msp2 superfamily YP_154293.1 member of msp2 superfamily YP_154294.1 member of msp2 superfamily YP_154295.1 member of msp2 superfamily YP_154296.1 member of msp2 superfamily YP_154297.1 hypothetical protein identified by Glimmer 2 YP_154298.1 hypothetical protein identified by Glimmer 2 YP_154299.1 conserved hypothetical protein similar to NP_966513.1 YP_154300.1 COG0728 MviN uncharacterized membrane protein virulence factor; similar to NP_360535.1 YP_154301.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_154302.1 hypothetical protein identified by Glimmer 2 YP_154303.2 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_154304.1 COG0204 PlsC 1-acyl-sn-glycerol-3-phosphate acyltransferase; similar to NP_538993.1 YP_154305.1 COG0242 Def N-formylmethionyl-tRNA deformylase YP_154306.1 conserved hypothetical protein similar to NP_221193.1 YP_154307.1 hypothetical protein identified by Glimmer 2 YP_154308.1 hypothetical protein identified by Glimmer 2 YP_154309.1 hypothetical protein identified by Glimmer 2 YP_154310.1 hypothetical protein identified by Glimmer 2 YP_154311.1 hypothetical protein identified by Glimmer 2 YP_154312.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_154313.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane YP_154314.1 hypothetical protein identified by Glimmer 2 YP_154315.1 other copies include: AM032, AM046, AM063, AM721 AM990 and AM1059; member of msp2 superfamily YP_154316.1 other copies include: AM030, AM044, AM065, AM077 AM082, AM210, AM717, AM723, AM989, AM1061 and AM1149; member of msp2 superfamily YP_154317.1 conserved family - 3-octaprenyl-4-hydroxybenzoate carboxy-lyase YP_154318.1 member of msp2 superfamily YP_154319.1 member of msp2 superfamily YP_154320.1 member of msp2 superfamily YP_154321.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_154322.1 conserved hypothetical protein similar to NP_966484.1 YP_154323.1 COG1192 Soj ATPases involved in chromosome partitioning; similar to NP_699034.1 YP_154324.1 COG1475 Spo0J predicted transcriptional regulators; similar to NP_105340.1 YP_154325.1 Essential for efficient processing of 16S rRNA YP_154326.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_154327.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_154328.1 COG1058 CinA predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA YP_154329.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) YP_154330.1 COG0290 InfC translation initiation factor IF3 YP_154331.1 conserved hypothetical protein similar to ZP_00142507.1 YP_154332.1 conserved family - integral membrane protein YP_154333.1 COG0136 Asd aspartate-semialdehyde dehydrogenase YP_154334.1 conserved hypothetical protein similar to NP_966784.1 YP_154335.1 COG2812 DnaX DNA polymerase III, gamma/tau subunits YP_154336.1 COG0057 GapA glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase YP_154337.1 hypothetical protein identified by Glimmer 2 YP_154338.1 conserved hypothetical protein similar to NP_755835.1 YP_154339.1 COG0772 FtsW bacterial cell division membrane protein; similar to NP_220792.1 YP_154340.1 methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_154341.1 COG0654 UbiH 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases; similar to NP_539083.1 YP_154342.1 conserved hypothetical protein similar to ZP_00211261.1 YP_154343.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_154344.1 COG0751 GlyS glycyl-tRNA synthetase, beta subunit YP_154345.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_154346.1 COG0157 NadC nicotinate-nucleotide pyrophosphorylase YP_154347.1 conserved hypothetical protein similar to NP_966768.1 YP_154348.1 COG0817 RuvC holliday junction resolvasome endonuclease subunit YP_154349.1 COG1845 CyoC heme/copper-type cytochrome/quinol oxidase subunit 3 YP_154350.1 COG0407 HemE uroporphyrinogen-III decarboxylase YP_154351.1 conserved family - hemolysin YP_154352.1 COG3740 - phage head maturation protease YP_154354.1 conserved family - biotin synthesis protein YP_154355.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate YP_154356.1 COG1145 NapF ferredoxin 2; similar to NP_539195.1 YP_154357.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_154358.1 COG0290 InfC translation initiation factor IF3 YP_154359.1 COG3505 VirD4 type IV secretory pathway, VirD4 components; similar to AAM00422.1 YP_154360.1 COG0630 VirB11 type IV secretory pathway VirB11 components, and related ATPases involved in; similar to AAM00419.1 YP_154361.1 COG2948 VirB10 type IV secretory pathway VirB10 components; similar to AAM00418.1 YP_154362.1 COG3504 VirB9 type IV secretory pathway, VirB9 components; similar to AAM00421.1 YP_154363.1 COG3736 VirB8 type IV secretion system component VirB8 YP_154364.1 COG0807 RibA GTP cyclohydrolase II; other copies include AM120 and AM1172 YP_154365.1 conserved family - TPR domain protein YP_154366.1 hypothetical protein identified by Glimmer 2 YP_154367.1 COG0253 DapF diaminopimelate epimerase YP_154368.1 hypothetical protein identified by Glimmer 2 YP_154369.1 conserved hypothetical protein similar to ZP_00211235.1 YP_154370.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_154371.1 COG1570 XseA exonuclease VII, large subunit YP_154372.1 conserved hypothetical protein similar to ZP_00211231.1 YP_154373.2 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway YP_154374.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_154375.1 decarboxylates 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine. YP_154376.1 COG1200 RecG RecG-like helicases; similar to NP_699765.1 YP_154377.1 conserved family - NADH-ubiquinone oxidoreductase YP_154378.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_154379.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_154380.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_154381.1 hypothetical protein identified by Glimmer 2 YP_154382.1 conserved family - competence protein F YP_154383.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. YP_154384.1 COG0475 KefB Kef-type K+ transport systems membrane components; similar to AAL24515.1 YP_154385.1 conserved hypothetical protein similar to NP_966962.1 YP_154386.1 conserved hypothetical protein similar to NP_221229.1 YP_154387.1 catalyzes the oxidative decarboxylation of pyruvate with concomitant acetylation of a lipoic acid-containing dihydrolipoamide acyltransferase within the complex. The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2); it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase YP_154388.1 hypothetical protein identified by Glimmer 2 YP_154389.1 COG0312 TldD predicted Zn-dependent proteases and their inactivated homologs; similar to NP_531465.1 YP_154390.1 hypothetical protein identified by Glimmer 2 YP_154391.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_154392.1 COG0245 IspF 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; similar to NP_755192.1 YP_154393.1 COG1211 IspD 4-diphosphocytidyl-2-methyl-D-erithritol synthase; similar to NP_698125.1