-- dump date 20140618_190646 -- class Genbank::misc_feature -- table misc_feature_note -- id note 509170000001 Initiator Replication protein; Region: Rep_3; pfam01051 509170000002 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 509170000003 active site 509170000004 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 509170000005 Initiator Replication protein; Region: Rep_3; pfam01051 509170000006 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 509170000007 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 509170000008 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 509170000009 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 509170000010 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 509170000011 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170000012 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000013 Evidence 7 : Gene remnant; Product type f : factor 509170000014 HpaII restriction endonuclease; Region: RE_HpaII; pfam09561 509170000015 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 509170000016 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 509170000017 cofactor binding site; other site 509170000018 DNA binding site [nucleotide binding] 509170000019 substrate interaction site [chemical binding]; other site 509170000020 Evidence 7 : Gene remnant; Product type pf : putative factor 509170000021 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 509170000022 Initiator Replication protein; Region: Rep_3; pfam01051 509170000023 MobA/MobL family; Region: MobA_MobL; pfam03389 509170000024 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 509170000025 RelB antitoxin; Region: RelB; cl01171 509170000026 PAAR motif; Region: PAAR_motif; pfam05488 509170000027 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 509170000028 Initiator Replication protein; Region: Rep_3; pfam01051 509170000029 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 509170000030 catalytic residue [active] 509170000031 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 509170000032 Initiator Replication protein; Region: Rep_3; pfam01051 509170000033 MobA/MobL family; Region: MobA_MobL; pfam03389 509170000034 DNA methylase; Region: N6_N4_Mtase; cl17433 509170000035 Methyltransferase domain; Region: Methyltransf_26; pfam13659 509170000036 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 509170000037 Catalytic domain of type IIs restriction endonuclease BfiI and similar proteins; Region: PLDc_Bfil; cd09175 509170000038 homodimer interface [polypeptide binding]; other site 509170000039 PLD-like domain; Region: PLDc_2; pfam13091 509170000040 putative active site [active] 509170000041 catalytic site [active] 509170000042 C-terminal domain of type IIs restriction endonuclease BfiI and similar proteins; Region: BfiI_C; cd10018 509170000043 putative DNA binding site [nucleotide binding]; other site 509170000044 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170000045 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000046 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 509170000047 Initiator Replication protein; Region: Rep_3; pfam01051 509170000048 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 509170000049 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 509170000050 DNA-binding site [nucleotide binding]; DNA binding site 509170000051 RNA-binding motif; other site 509170000052 Evidence 7 : Gene remnant; Product type e : enzyme 509170000053 Evidence 7 : Gene remnant; Product type e : enzyme 509170000054 hydroperoxidase II; Provisional; Region: katE; PRK11249 509170000055 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 509170000056 heme binding pocket [chemical binding]; other site 509170000057 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 509170000058 domain interactions; other site 509170000059 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 509170000060 conserved cys residue [active] 509170000061 DnaA N-terminal domain; Region: DnaA_N; pfam11638 509170000062 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 509170000063 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170000064 Walker A motif; other site 509170000065 ATP binding site [chemical binding]; other site 509170000066 Walker B motif; other site 509170000067 arginine finger; other site 509170000068 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 509170000069 DnaA box-binding interface [nucleotide binding]; other site 509170000070 DNA polymerase III subunit beta; Validated; Region: PRK05643 509170000071 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 509170000072 putative DNA binding surface [nucleotide binding]; other site 509170000073 dimer interface [polypeptide binding]; other site 509170000074 beta-clamp/clamp loader binding surface; other site 509170000075 beta-clamp/translesion DNA polymerase binding surface; other site 509170000076 recombination protein F; Reviewed; Region: recF; PRK00064 509170000077 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 509170000078 Walker A/P-loop; other site 509170000079 ATP binding site [chemical binding]; other site 509170000080 Q-loop/lid; other site 509170000081 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 509170000082 ABC transporter signature motif; other site 509170000083 Walker B; other site 509170000084 D-loop; other site 509170000085 H-loop/switch region; other site 509170000086 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 509170000087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509170000088 ATP binding site [chemical binding]; other site 509170000089 Mg2+ binding site [ion binding]; other site 509170000090 G-X-G motif; other site 509170000091 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 509170000092 anchoring element; other site 509170000093 dimer interface [polypeptide binding]; other site 509170000094 ATP binding site [chemical binding]; other site 509170000095 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 509170000096 active site 509170000097 putative metal-binding site [ion binding]; other site 509170000098 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 509170000099 Cytochrome b562; Region: Cytochrom_B562; pfam07361 509170000100 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 509170000101 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 509170000102 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 509170000103 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 509170000104 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 509170000105 ABC transporter; Region: ABC_tran_2; pfam12848 509170000106 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 509170000107 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 509170000108 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 509170000109 Evidence 7 : Gene remnant 509170000110 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170000111 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170000112 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000113 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170000114 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000115 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170000116 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 509170000117 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 509170000118 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 509170000119 active site 509170000120 HIGH motif; other site 509170000121 dimer interface [polypeptide binding]; other site 509170000122 KMSKS motif; other site 509170000123 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170000124 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000125 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 509170000126 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 509170000127 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 509170000128 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 509170000129 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 509170000130 active site 509170000131 HIGH motif; other site 509170000132 nucleotide binding site [chemical binding]; other site 509170000133 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 509170000134 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 509170000135 active site 509170000136 KMSKS motif; other site 509170000137 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 509170000138 tRNA binding surface [nucleotide binding]; other site 509170000139 anticodon binding site; other site 509170000140 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 509170000141 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 509170000142 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 509170000143 active site 509170000144 Riboflavin kinase; Region: Flavokinase; smart00904 509170000145 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 509170000146 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318 509170000147 gating phenylalanine in ion channel; other site 509170000148 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 509170000149 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 509170000150 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509170000151 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 509170000152 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 509170000153 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 509170000154 Walker A/P-loop; other site 509170000155 ATP binding site [chemical binding]; other site 509170000156 Q-loop/lid; other site 509170000157 ABC transporter signature motif; other site 509170000158 Walker B; other site 509170000159 D-loop; other site 509170000160 H-loop/switch region; other site 509170000161 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 509170000162 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 509170000163 putative PBP binding loops; other site 509170000164 dimer interface [polypeptide binding]; other site 509170000165 ABC-ATPase subunit interface; other site 509170000166 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 509170000167 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 509170000168 active site 509170000169 dimer interface [polypeptide binding]; other site 509170000170 non-prolyl cis peptide bond; other site 509170000171 insertion regions; other site 509170000172 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170000173 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000174 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 509170000175 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 509170000176 substrate binding pocket [chemical binding]; other site 509170000177 membrane-bound complex binding site; other site 509170000178 hinge residues; other site 509170000179 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 509170000180 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 509170000181 substrate binding pocket [chemical binding]; other site 509170000182 membrane-bound complex binding site; other site 509170000183 N-acetylglutamate synthase; Validated; Region: PRK05279 509170000184 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 509170000185 putative feedback inhibition sensing region; other site 509170000186 putative nucleotide binding site [chemical binding]; other site 509170000187 putative substrate binding site [chemical binding]; other site 509170000188 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 509170000189 Coenzyme A binding pocket [chemical binding]; other site 509170000190 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170000191 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000192 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 509170000193 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 509170000194 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 509170000195 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170000196 NAD(P) binding site [chemical binding]; other site 509170000197 active site 509170000198 phosphoglycolate phosphatase; Provisional; Region: PRK13222 509170000199 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 509170000200 active site 509170000201 motif I; other site 509170000202 motif II; other site 509170000203 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 509170000204 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509170000205 S-adenosylmethionine binding site [chemical binding]; other site 509170000206 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 509170000207 catalytic residues [active] 509170000208 hinge region; other site 509170000209 alpha helical domain; other site 509170000210 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509170000211 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509170000212 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 509170000213 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509170000214 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 509170000215 FMN reductase; Validated; Region: fre; PRK08051 509170000216 FAD binding pocket [chemical binding]; other site 509170000217 FAD binding motif [chemical binding]; other site 509170000218 phosphate binding motif [ion binding]; other site 509170000219 beta-alpha-beta structure motif; other site 509170000220 NAD binding pocket [chemical binding]; other site 509170000221 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 509170000222 catalytic loop [active] 509170000223 iron binding site [ion binding]; other site 509170000224 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 509170000225 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 509170000226 putative di-iron ligands [ion binding]; other site 509170000227 ribonuclease PH; Reviewed; Region: rph; PRK00173 509170000228 Ribonuclease PH; Region: RNase_PH_bact; cd11362 509170000229 hexamer interface [polypeptide binding]; other site 509170000230 active site 509170000231 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 509170000232 Phosphoesterase family; Region: Phosphoesterase; pfam04185 509170000233 Domain of unknown function (DUF756); Region: DUF756; pfam05506 509170000234 Domain of unknown function (DUF756); Region: DUF756; pfam05506 509170000235 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170000236 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 509170000237 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 509170000238 dimerization interface [polypeptide binding]; other site 509170000239 active site 509170000240 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 509170000241 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 509170000242 amidase catalytic site [active] 509170000243 Zn binding residues [ion binding]; other site 509170000244 substrate binding site [chemical binding]; other site 509170000245 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170000246 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000247 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 509170000248 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 509170000249 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170000250 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000251 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 509170000252 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 509170000253 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 509170000254 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 509170000255 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 509170000256 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 509170000257 tyrosine kinase; Provisional; Region: PRK11519 509170000258 Chain length determinant protein; Region: Wzz; pfam02706 509170000259 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 509170000260 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 509170000261 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 509170000262 Low molecular weight phosphatase family; Region: LMWPc; cd00115 509170000263 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 509170000264 active site 509170000265 polysaccharide export protein Wza; Provisional; Region: PRK15078 509170000266 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 509170000267 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 509170000268 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 509170000269 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 509170000270 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 509170000271 NAD(P) binding site [chemical binding]; other site 509170000272 homodimer interface [polypeptide binding]; other site 509170000273 substrate binding site [chemical binding]; other site 509170000274 active site 509170000275 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 509170000276 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 509170000277 inhibitor-cofactor binding pocket; inhibition site 509170000278 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170000279 catalytic residue [active] 509170000280 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 509170000281 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 509170000282 active site 509170000283 homodimer interface [polypeptide binding]; other site 509170000284 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 509170000285 NeuB family; Region: NeuB; pfam03102 509170000286 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 509170000287 NeuB binding interface [polypeptide binding]; other site 509170000288 putative substrate binding site [chemical binding]; other site 509170000289 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 509170000290 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 509170000291 putative trimer interface [polypeptide binding]; other site 509170000292 putative CoA binding site [chemical binding]; other site 509170000293 FOG: CBS domain [General function prediction only]; Region: COG0517 509170000294 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 509170000295 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 509170000296 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 509170000297 Substrate binding site; other site 509170000298 metal-binding site 509170000299 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 509170000300 ligand binding site; other site 509170000301 tetramer interface; other site 509170000302 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 509170000303 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 509170000304 Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922 509170000305 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 509170000306 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 509170000307 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 509170000308 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 509170000309 putative ADP-binding pocket [chemical binding]; other site 509170000310 Bacterial sugar transferase; Region: Bac_transf; pfam02397 509170000311 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 509170000312 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 509170000313 active site 509170000314 tetramer interface; other site 509170000315 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 509170000316 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 509170000317 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 509170000318 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 509170000319 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 509170000320 active site 509170000321 dimer interface [polypeptide binding]; other site 509170000322 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 509170000323 dimer interface [polypeptide binding]; other site 509170000324 active site 509170000325 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 509170000326 UDP-glucose 4-epimerase; Region: PLN02240 509170000327 NAD binding site [chemical binding]; other site 509170000328 homodimer interface [polypeptide binding]; other site 509170000329 active site 509170000330 substrate binding site [chemical binding]; other site 509170000331 phosphomannomutase CpsG; Provisional; Region: PRK15414 509170000332 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 509170000333 active site 509170000334 substrate binding site [chemical binding]; other site 509170000335 metal binding site [ion binding]; metal-binding site 509170000336 Evidence 7 : Gene remnant; Product type t : transporter; fragment of L-lactate permease (part 1) 509170000337 Evidence 7 : Gene remnant; Product type t : transporter; fragment of L-lactate permease (part 2) 509170000338 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 509170000339 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509170000340 DNA-binding site [nucleotide binding]; DNA binding site 509170000341 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 509170000342 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 509170000343 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 509170000344 active site 509170000345 substrate binding site [chemical binding]; other site 509170000346 FMN binding site [chemical binding]; other site 509170000347 putative catalytic residues [active] 509170000348 D-lactate dehydrogenase; Provisional; Region: PRK11183 509170000349 FAD binding domain; Region: FAD_binding_4; pfam01565 509170000350 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 509170000351 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 509170000352 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 509170000353 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170000354 homodimer interface [polypeptide binding]; other site 509170000355 catalytic residue [active] 509170000356 Transcriptional regulators [Transcription]; Region: GntR; COG1802 509170000357 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509170000358 DNA-binding site [nucleotide binding]; DNA binding site 509170000359 FCD domain; Region: FCD; pfam07729 509170000360 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 509170000361 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 509170000362 tetramer interface [polypeptide binding]; other site 509170000363 active site 509170000364 Mg2+/Mn2+ binding site [ion binding]; other site 509170000365 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 509170000366 methylcitrate synthase; Provisional; Region: PRK12351 509170000367 oxalacetate binding site [chemical binding]; other site 509170000368 citrylCoA binding site [chemical binding]; other site 509170000369 coenzyme A binding site [chemical binding]; other site 509170000370 catalytic triad [active] 509170000371 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 509170000372 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 509170000373 substrate binding site [chemical binding]; other site 509170000374 ligand binding site [chemical binding]; other site 509170000375 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 509170000376 substrate binding site [chemical binding]; other site 509170000377 Protein of unknown function (DUF1451); Region: DUF1451; pfam07295 509170000378 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 509170000379 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 509170000380 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 509170000381 Coenzyme A binding pocket [chemical binding]; other site 509170000382 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170000383 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000384 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170000385 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000386 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170000387 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170000388 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000389 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170000390 NAD(P) binding site [chemical binding]; other site 509170000391 active site 509170000392 Predicted membrane protein [Function unknown]; Region: COG4420 509170000393 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170000394 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000395 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 509170000396 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 509170000397 active site 509170000398 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 509170000399 SnoaL-like domain; Region: SnoaL_2; pfam12680 509170000400 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 509170000401 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509170000402 N-terminal plug; other site 509170000403 ligand-binding site [chemical binding]; other site 509170000404 Predicted membrane protein [Function unknown]; Region: COG3503 509170000405 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 509170000406 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 509170000407 putative DNA binding site [nucleotide binding]; other site 509170000408 putative Zn2+ binding site [ion binding]; other site 509170000409 AsnC family; Region: AsnC_trans_reg; pfam01037 509170000410 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 509170000411 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 509170000412 mRNA stabilisation; Region: mRNA_stabil; pfam13929 509170000413 alanine racemase; Reviewed; Region: dadX; PRK03646 509170000414 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 509170000415 active site 509170000416 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 509170000417 substrate binding site [chemical binding]; other site 509170000418 catalytic residues [active] 509170000419 dimer interface [polypeptide binding]; other site 509170000420 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 509170000421 homotrimer interaction site [polypeptide binding]; other site 509170000422 putative active site [active] 509170000423 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 509170000424 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509170000425 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509170000426 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509170000427 dimerization interface [polypeptide binding]; other site 509170000428 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 509170000429 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 509170000430 tetrameric interface [polypeptide binding]; other site 509170000431 NAD binding site [chemical binding]; other site 509170000432 catalytic residues [active] 509170000433 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 509170000434 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 509170000435 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 509170000436 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 509170000437 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 509170000438 acyl-activating enzyme (AAE) consensus motif; other site 509170000439 AMP binding site [chemical binding]; other site 509170000440 active site 509170000441 CoA binding site [chemical binding]; other site 509170000442 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 509170000443 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509170000444 active site 509170000445 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of enoyl-CoA hydratase/isomerase (part 1) 509170000446 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of enoyl-CoA hydratase/isomerase (part 2) 509170000447 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 509170000448 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 509170000449 substrate binding site [chemical binding]; other site 509170000450 oxyanion hole (OAH) forming residues; other site 509170000451 trimer interface [polypeptide binding]; other site 509170000452 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 509170000453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170000454 metabolite-proton symporter; Region: 2A0106; TIGR00883 509170000455 putative substrate translocation pore; other site 509170000456 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of N-acylhomoserine lactone synthase, autoinducer synthesis protein 509170000457 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170000458 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000459 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of 4'-phosphopantetheinyl transferase (partial) 509170000460 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 509170000461 Invasion gene expression up-regulator, SirB; Region: SirB; cl01184 509170000462 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 509170000463 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 509170000464 P-loop; other site 509170000465 Magnesium ion binding site [ion binding]; other site 509170000466 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 509170000467 Magnesium ion binding site [ion binding]; other site 509170000468 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 509170000469 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 509170000470 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 509170000471 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170000472 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170000473 Predicted membrane protein [Function unknown]; Region: COG2259 509170000474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 509170000475 GMP synthase; Reviewed; Region: guaA; PRK00074 509170000476 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 509170000477 AMP/PPi binding site [chemical binding]; other site 509170000478 candidate oxyanion hole; other site 509170000479 catalytic triad [active] 509170000480 potential glutamine specificity residues [chemical binding]; other site 509170000481 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 509170000482 ATP Binding subdomain [chemical binding]; other site 509170000483 Ligand Binding sites [chemical binding]; other site 509170000484 Dimerization subdomain; other site 509170000485 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 509170000486 active site 509170000487 NTP binding site [chemical binding]; other site 509170000488 metal binding triad [ion binding]; metal-binding site 509170000489 antibiotic binding site [chemical binding]; other site 509170000490 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 509170000491 Predicted transcriptional regulators [Transcription]; Region: COG1695 509170000492 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 509170000493 Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977 509170000494 Pirin; Region: Pirin; pfam02678 509170000495 Pirin-related protein [General function prediction only]; Region: COG1741 509170000496 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 509170000497 OsmC-like protein; Region: OsmC; pfam02566 509170000498 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of glutathione S-transferase (part 1) 509170000499 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170000500 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000501 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of glutathione S-transferase (part 2) 509170000502 Sporulation related domain; Region: SPOR; pfam05036 509170000503 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 509170000504 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 509170000505 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 509170000506 active site 509170000507 HIGH motif; other site 509170000508 nucleotide binding site [chemical binding]; other site 509170000509 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 509170000510 KMSK motif region; other site 509170000511 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 509170000512 tRNA binding surface [nucleotide binding]; other site 509170000513 anticodon binding site; other site 509170000514 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170000515 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000516 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 509170000517 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 509170000518 ABC-ATPase subunit interface; other site 509170000519 dimer interface [polypeptide binding]; other site 509170000520 putative PBP binding regions; other site 509170000521 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 509170000522 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 509170000523 Walker A/P-loop; other site 509170000524 ATP binding site [chemical binding]; other site 509170000525 Q-loop/lid; other site 509170000526 ABC transporter signature motif; other site 509170000527 Walker B; other site 509170000528 D-loop; other site 509170000529 H-loop/switch region; other site 509170000530 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 509170000531 metal binding site 2 [ion binding]; metal-binding site 509170000532 putative DNA binding helix; other site 509170000533 metal binding site 1 [ion binding]; metal-binding site 509170000534 dimer interface [polypeptide binding]; other site 509170000535 structural Zn2+ binding site [ion binding]; other site 509170000536 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 509170000537 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 509170000538 intersubunit interface [polypeptide binding]; other site 509170000539 F0F1 ATP synthase subunit I; Validated; Region: PRK05760 509170000540 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 509170000541 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 509170000542 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 509170000543 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 509170000544 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 509170000545 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 509170000546 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 509170000547 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 509170000548 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 509170000549 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 509170000550 Walker A motif; other site 509170000551 ATP binding site [chemical binding]; other site 509170000552 Walker B motif; other site 509170000553 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 509170000554 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 509170000555 core domain interface [polypeptide binding]; other site 509170000556 delta subunit interface [polypeptide binding]; other site 509170000557 epsilon subunit interface [polypeptide binding]; other site 509170000558 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 509170000559 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 509170000560 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 509170000561 alpha subunit interaction interface [polypeptide binding]; other site 509170000562 Walker A motif; other site 509170000563 ATP binding site [chemical binding]; other site 509170000564 Walker B motif; other site 509170000565 inhibitor binding site; inhibition site 509170000566 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 509170000567 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 509170000568 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 509170000569 gamma subunit interface [polypeptide binding]; other site 509170000570 epsilon subunit interface [polypeptide binding]; other site 509170000571 LBP interface [polypeptide binding]; other site 509170000572 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170000573 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000574 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170000575 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 509170000576 catalytic residues [active] 509170000577 dimer interface [polypeptide binding]; other site 509170000578 Helix-turn-helix domain; Region: HTH_18; pfam12833 509170000579 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509170000580 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 509170000581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170000582 putative substrate translocation pore; other site 509170000583 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509170000584 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509170000585 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 509170000586 EamA-like transporter family; Region: EamA; pfam00892 509170000587 EamA-like transporter family; Region: EamA; pfam00892 509170000588 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 509170000589 Evidence 7 : Gene remnant; Product type pf : factor; fragment of Rossmann-fold nucleotide-binding protein involved in DNA uptake (Smf) (part 3) 509170000590 Evidence 7 : Gene remnant; Product type pf : factor; fragment of Rossmann-fold nucleotide-binding protein involved in DNA uptake (Smf) (part 2) 509170000591 Evidence 7 : Gene remnant; Product type pf : factor; fragment of Rossmann-fold nucleotide-binding protein involved in DNA uptake (Smf) (part 1) 509170000592 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 509170000593 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 509170000594 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 509170000595 active site 509170000596 catalytic residues [active] 509170000597 metal binding site [ion binding]; metal-binding site 509170000598 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 509170000599 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509170000600 N-terminal plug; other site 509170000601 ligand-binding site [chemical binding]; other site 509170000602 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170000603 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 509170000604 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of transcription regulator protein (TetR family) (part 1) 509170000605 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170000606 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000607 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of transcription regulator protein (TetR family) (part 2) 509170000608 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of acetyltransferase (part 1) 509170000609 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170000610 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000611 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170000612 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000613 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170000614 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000615 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of acetyltransferase (part 2) 509170000616 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 509170000617 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 509170000618 dimer interface [polypeptide binding]; other site 509170000619 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170000620 catalytic residue [active] 509170000621 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 509170000622 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 509170000623 N-acetyl-D-glucosamine binding site [chemical binding]; other site 509170000624 catalytic residue [active] 509170000625 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170000626 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170000627 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000628 hypothetical protein; Provisional; Region: PRK01254 509170000629 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 509170000630 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 509170000631 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 509170000632 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 509170000633 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 509170000634 homotrimer interaction site [polypeptide binding]; other site 509170000635 putative active site [active] 509170000636 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 509170000637 active site 509170000638 DNA polymerase IV; Validated; Region: PRK02406 509170000639 DNA binding site [nucleotide binding] 509170000640 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of lysozyme (partial) 509170000641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170000642 putative transporter; Provisional; Region: PRK10504 509170000643 putative substrate translocation pore; other site 509170000644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170000645 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 509170000646 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 509170000647 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 509170000648 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 509170000649 Transporter associated domain; Region: CorC_HlyC; smart01091 509170000650 hypothetical protein; Provisional; Region: PRK01752 509170000651 SEC-C motif; Region: SEC-C; pfam02810 509170000652 Predicted membrane protein [Function unknown]; Region: COG2860 509170000653 UPF0126 domain; Region: UPF0126; pfam03458 509170000654 UPF0126 domain; Region: UPF0126; pfam03458 509170000655 benzoate transport; Region: 2A0115; TIGR00895 509170000656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170000657 putative substrate translocation pore; other site 509170000658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170000659 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 509170000660 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 509170000661 CAP-like domain; other site 509170000662 active site 509170000663 primary dimer interface [polypeptide binding]; other site 509170000664 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 509170000665 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 509170000666 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 509170000667 acyl-activating enzyme (AAE) consensus motif; other site 509170000668 putative AMP binding site [chemical binding]; other site 509170000669 putative active site [active] 509170000670 putative CoA binding site [chemical binding]; other site 509170000671 MAPEG family; Region: MAPEG; cl09190 509170000672 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 509170000673 dimer interface [polypeptide binding]; other site 509170000674 substrate binding site [chemical binding]; other site 509170000675 metal binding sites [ion binding]; metal-binding site 509170000676 outer membrane porin, OprD family; Region: OprD; pfam03573 509170000677 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170000678 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170000679 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170000680 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 509170000681 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 509170000682 substrate binding site [chemical binding]; other site 509170000683 glutamase interaction surface [polypeptide binding]; other site 509170000684 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 509170000685 Phosphotransferase enzyme family; Region: APH; pfam01636 509170000686 putative active site [active] 509170000687 putative substrate binding site [chemical binding]; other site 509170000688 ATP binding site [chemical binding]; other site 509170000689 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of cold shock protein (part 1) 509170000690 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of cold shock protein (part 2) 509170000691 Predicted membrane protein [Function unknown]; Region: COG3671 509170000692 Evidence 7 : Gene remnant; Product type pm : membrane component; fragment of membrane protein (partial) 509170000693 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170000694 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000695 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170000696 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000697 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of transport protein (ABC superfamily, atp_bind) (partial) 509170000698 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170000699 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000700 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 509170000701 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 509170000702 catalytic residues [active] 509170000703 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170000704 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170000705 Protein of unknown function (DUF805); Region: DUF805; pfam05656 509170000706 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 509170000707 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 509170000708 putative active site [active] 509170000709 oxyanion strand; other site 509170000710 catalytic triad [active] 509170000711 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 509170000712 putative active site pocket [active] 509170000713 4-fold oligomerization interface [polypeptide binding]; other site 509170000714 metal binding residues [ion binding]; metal-binding site 509170000715 3-fold/trimer interface [polypeptide binding]; other site 509170000716 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 509170000717 Coenzyme A binding pocket [chemical binding]; other site 509170000718 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of acyltransferase (part 2) 509170000719 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170000720 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000721 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of acyltransferase (part 1) 509170000722 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 509170000723 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 509170000724 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 509170000725 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 509170000726 HAMP domain; Region: HAMP; pfam00672 509170000727 dimerization interface [polypeptide binding]; other site 509170000728 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509170000729 dimer interface [polypeptide binding]; other site 509170000730 phosphorylation site [posttranslational modification] 509170000731 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509170000732 ATP binding site [chemical binding]; other site 509170000733 Mg2+ binding site [ion binding]; other site 509170000734 G-X-G motif; other site 509170000735 osmolarity response regulator; Provisional; Region: ompR; PRK09468 509170000736 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509170000737 active site 509170000738 phosphorylation site [posttranslational modification] 509170000739 intermolecular recognition site; other site 509170000740 dimerization interface [polypeptide binding]; other site 509170000741 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 509170000742 DNA binding site [nucleotide binding] 509170000743 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 509170000744 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 509170000745 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 509170000746 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 509170000747 RNA binding site [nucleotide binding]; other site 509170000748 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170000749 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170000750 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000751 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170000752 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 509170000753 Sulfate transporter family; Region: Sulfate_transp; pfam00916 509170000754 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 509170000755 active site clefts [active] 509170000756 zinc binding site [ion binding]; other site 509170000757 dimer interface [polypeptide binding]; other site 509170000758 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 509170000759 classical (c) SDRs; Region: SDR_c; cd05233 509170000760 NAD(P) binding site [chemical binding]; other site 509170000761 active site 509170000762 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of homocysteine synthase (part 2) 509170000763 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of homocysteine synthase (part 1) 509170000764 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 509170000765 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 509170000766 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 509170000767 ABC transporter; Region: ABC_tran_2; pfam12848 509170000768 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 509170000769 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 509170000770 Sel1-like repeats; Region: SEL1; smart00671 509170000771 hypothetical protein; Provisional; Region: PRK10215 509170000772 Outer membrane efflux protein; Region: OEP; pfam02321 509170000773 Outer membrane efflux protein; Region: OEP; pfam02321 509170000774 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 509170000775 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 509170000776 HlyD family secretion protein; Region: HlyD_3; pfam13437 509170000777 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 509170000778 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170000779 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170000780 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 509170000781 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170000782 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000783 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170000784 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170000785 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170000786 S-methylmethionine transporter; Provisional; Region: PRK11387 509170000787 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 509170000788 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 509170000789 active site 509170000790 HIGH motif; other site 509170000791 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 509170000792 active site 509170000793 KMSKS motif; other site 509170000794 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 509170000795 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 509170000796 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 509170000797 MraW methylase family; Region: Methyltransf_5; cl17771 509170000798 Cell division protein FtsL; Region: FtsL; pfam04999 509170000799 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 509170000800 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 509170000801 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 509170000802 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 509170000803 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 509170000804 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 509170000805 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 509170000806 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 509170000807 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 509170000808 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 509170000809 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 509170000810 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 509170000811 Mg++ binding site [ion binding]; other site 509170000812 putative catalytic motif [active] 509170000813 putative substrate binding site [chemical binding]; other site 509170000814 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170000815 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170000816 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000817 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170000818 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 509170000819 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509170000820 S-adenosylmethionine binding site [chemical binding]; other site 509170000821 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 509170000822 Transglycosylase; Region: Transgly; pfam00912 509170000823 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 509170000824 Competence protein A; Region: Competence_A; pfam11104 509170000825 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 509170000826 Evidence 7 : Gene remnant; Product type pm : membrane component; fragment of membrane protein (ComN) (part 1) 509170000827 Evidence 7 : Gene remnant; Product type pm : membrane component; fragment of membrane protein (ComN) (part 2) 509170000828 Pilus assembly protein, PilO; Region: PilO; pfam04350 509170000829 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 509170000830 Pilus assembly protein, PilP; Region: PilP; pfam04351 509170000831 Evidence 7 : Gene remnant; Product type pm : membrane component; fragment of outer membrane protein (ComQ) (part 1) 509170000832 Evidence 7 : Gene remnant; Product type pm : membrane component; fragment of outer membrane protein (ComQ) (part 2) 509170000833 Evidence 7 : Gene remnant; Product type pm : membrane component; fragment of outer membrane protein (ComQ) (part 3) 509170000834 shikimate kinase; Reviewed; Region: aroK; PRK00131 509170000835 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 509170000836 ADP binding site [chemical binding]; other site 509170000837 magnesium binding site [ion binding]; other site 509170000838 putative shikimate binding site; other site 509170000839 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 509170000840 active site 509170000841 dimer interface [polypeptide binding]; other site 509170000842 metal binding site [ion binding]; metal-binding site 509170000843 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 509170000844 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 509170000845 active site 509170000846 dimer interface [polypeptide binding]; other site 509170000847 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 509170000848 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 509170000849 active site 509170000850 FMN binding site [chemical binding]; other site 509170000851 substrate binding site [chemical binding]; other site 509170000852 3Fe-4S cluster binding site [ion binding]; other site 509170000853 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 509170000854 domain interface; other site 509170000855 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 509170000856 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 509170000857 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 509170000858 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 509170000859 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 509170000860 LemA family; Region: LemA; pfam04011 509170000861 Repair protein; Region: Repair_PSII; pfam04536 509170000862 Repair protein; Region: Repair_PSII; pfam04536 509170000863 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170000864 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000865 Evidence 7 : Gene remnant; Product type ps : structure; fragment of fimbrial protein precursor (Pilin) (partial) 509170000866 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170000867 O-Antigen ligase; Region: Wzy_C; pfam04932 509170000868 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 509170000869 O-Antigen ligase; Region: Wzy_C; pfam04932 509170000870 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 509170000871 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 509170000872 heme binding site [chemical binding]; other site 509170000873 Ferritin-like domain; Region: Ferritin; pfam00210 509170000874 ferroxidase pore; other site 509170000875 ferroxidase diiron center [ion binding]; other site 509170000876 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 509170000877 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 509170000878 homotrimer interaction site [polypeptide binding]; other site 509170000879 putative active site [active] 509170000880 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 509170000881 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 509170000882 Zn2+ binding site [ion binding]; other site 509170000883 Mg2+ binding site [ion binding]; other site 509170000884 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 509170000885 synthetase active site [active] 509170000886 NTP binding site [chemical binding]; other site 509170000887 metal binding site [ion binding]; metal-binding site 509170000888 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 509170000889 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 509170000890 ACT domain; Region: ACT_4; pfam13291 509170000891 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 509170000892 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 509170000893 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 509170000894 catalytic site [active] 509170000895 G-X2-G-X-G-K; other site 509170000896 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 509170000897 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 509170000898 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170000899 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000900 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 509170000901 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 509170000902 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 509170000903 RimM N-terminal domain; Region: RimM; pfam01782 509170000904 PRC-barrel domain; Region: PRC; pfam05239 509170000905 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 509170000906 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 509170000907 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of lipase (part 2) 509170000908 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of lipase (part 1) 509170000909 lipase chaperone; Provisional; Region: PRK01294 509170000910 Proteobacterial lipase chaperone protein; Region: Lipase_chap; pfam03280 509170000911 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 509170000912 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 509170000913 RNA binding site [nucleotide binding]; other site 509170000914 active site 509170000915 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 509170000916 hypothetical protein; Provisional; Region: PRK10621 509170000917 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 509170000918 Hemerythrin-like domain; Region: Hr-like; cd12108 509170000919 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 509170000920 threonine and homoserine efflux system; Provisional; Region: PRK10532 509170000921 EamA-like transporter family; Region: EamA; pfam00892 509170000922 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 509170000923 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 509170000924 ligand binding site [chemical binding]; other site 509170000925 NAD binding site [chemical binding]; other site 509170000926 tetramer interface [polypeptide binding]; other site 509170000927 catalytic site [active] 509170000928 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 509170000929 L-serine binding site [chemical binding]; other site 509170000930 ACT domain interface; other site 509170000931 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 509170000932 FAD binding domain; Region: FAD_binding_4; pfam01565 509170000933 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170000934 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170000935 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000936 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 509170000937 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170000938 putative substrate translocation pore; other site 509170000939 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 509170000940 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 509170000941 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 509170000942 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 509170000943 E-class dimer interface [polypeptide binding]; other site 509170000944 P-class dimer interface [polypeptide binding]; other site 509170000945 active site 509170000946 Cu2+ binding site [ion binding]; other site 509170000947 Zn2+ binding site [ion binding]; other site 509170000948 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 509170000949 Domain of unknown function DUF20; Region: UPF0118; pfam01594 509170000950 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 509170000951 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 509170000952 P-loop; other site 509170000953 Magnesium ion binding site [ion binding]; other site 509170000954 Endonuclease related to archaeal Holliday junction resolvase; Region: Endonuc_Holl; cl01958 509170000955 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170000956 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170000957 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170000958 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000959 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 509170000960 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 509170000961 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 509170000962 NAD(P) binding site [chemical binding]; other site 509170000963 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 509170000964 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 509170000965 inhibitor-cofactor binding pocket; inhibition site 509170000966 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170000967 catalytic residue [active] 509170000968 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 509170000969 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 509170000970 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 509170000971 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 509170000972 NAD(P) binding site [chemical binding]; other site 509170000973 catalytic residues [active] 509170000974 succinylarginine dihydrolase; Provisional; Region: PRK13281 509170000975 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 509170000976 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 509170000977 putative active site [active] 509170000978 Zn binding site [ion binding]; other site 509170000979 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170000980 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000981 Evidence 4 : Homologs of previously reported genes of unknown function; fragment of conserved hypothetical protein; exported protein (partial) 509170000982 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 509170000983 active site 509170000984 catalytic residues [active] 509170000985 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170000986 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000987 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509170000988 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509170000989 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509170000990 dimerization interface [polypeptide binding]; other site 509170000991 EamA-like transporter family; Region: EamA; pfam00892 509170000992 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 509170000993 EamA-like transporter family; Region: EamA; pfam00892 509170000994 YCII-related domain; Region: YCII; cl00999 509170000995 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 509170000996 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 509170000997 dimer interface [polypeptide binding]; other site 509170000998 motif 1; other site 509170000999 active site 509170001000 motif 2; other site 509170001001 motif 3; other site 509170001002 Evidence 7 : Gene remnant; Product type t : transporter; fragment of Tetracycline resistance protein, class A (TETA(A)) (part 1) 509170001003 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170001004 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001005 Evidence 7 : Gene remnant; Product type t : transporter; fragment of Tetracycline resistance protein, class A (TETA(A)) (part 2) 509170001006 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 509170001007 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 509170001008 FeS/SAM binding site; other site 509170001009 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 509170001010 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170001011 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001012 PspC domain; Region: PspC; pfam04024 509170001013 hypothetical protein; Provisional; Region: PRK11615 509170001014 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 509170001015 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 509170001016 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509170001017 active site 509170001018 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 509170001019 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170001020 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001021 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein; signal peptide (part 1) 509170001022 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170001023 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 509170001024 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 509170001025 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 509170001026 shikimate binding site; other site 509170001027 NAD(P) binding site [chemical binding]; other site 509170001028 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 509170001029 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 509170001030 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 509170001031 dimerization interface [polypeptide binding]; other site 509170001032 active site 509170001033 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 509170001034 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 509170001035 TPP-binding site; other site 509170001036 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 509170001037 PYR/PP interface [polypeptide binding]; other site 509170001038 dimer interface [polypeptide binding]; other site 509170001039 TPP binding site [chemical binding]; other site 509170001040 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 509170001041 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 509170001042 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 509170001043 active site 509170001044 dimerization interface [polypeptide binding]; other site 509170001045 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 509170001046 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 509170001047 ATP binding site [chemical binding]; other site 509170001048 Mg++ binding site [ion binding]; other site 509170001049 motif III; other site 509170001050 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 509170001051 nucleotide binding region [chemical binding]; other site 509170001052 ATP-binding site [chemical binding]; other site 509170001053 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170001054 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001055 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 509170001056 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 509170001057 Walker A/P-loop; other site 509170001058 ATP binding site [chemical binding]; other site 509170001059 Q-loop/lid; other site 509170001060 ABC transporter signature motif; other site 509170001061 Walker B; other site 509170001062 D-loop; other site 509170001063 H-loop/switch region; other site 509170001064 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 509170001065 Permease; Region: Permease; cl00510 509170001066 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 509170001067 mce related protein; Region: MCE; pfam02470 509170001068 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 509170001069 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 509170001070 anti sigma factor interaction site; other site 509170001071 regulatory phosphorylation site [posttranslational modification]; other site 509170001072 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 509170001073 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 509170001074 Cl binding site [ion binding]; other site 509170001075 oligomer interface [polypeptide binding]; other site 509170001076 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 509170001077 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 509170001078 nudix motif; other site 509170001079 comF family protein; Region: comF; TIGR00201 509170001080 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 509170001081 active site 509170001082 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 509170001083 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 509170001084 ssDNA binding site; other site 509170001085 generic binding surface II; other site 509170001086 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 509170001087 ATP binding site [chemical binding]; other site 509170001088 putative Mg++ binding site [ion binding]; other site 509170001089 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 509170001090 nucleotide binding region [chemical binding]; other site 509170001091 ATP-binding site [chemical binding]; other site 509170001092 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170001093 NADH(P)-binding; Region: NAD_binding_10; pfam13460 509170001094 NAD(P) binding site [chemical binding]; other site 509170001095 active site 509170001096 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 509170001097 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 509170001098 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 509170001099 putative acyl-acceptor binding pocket; other site 509170001100 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 509170001101 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 509170001102 active site 509170001103 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 509170001104 catalytic triad [active] 509170001105 dimer interface [polypeptide binding]; other site 509170001106 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of Proton/sodium-glutamate symport protein (part 1) 509170001107 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of Proton/sodium-glutamate symport protein (part 2) 509170001108 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170001109 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001110 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of Proton/sodium-glutamate symport protein (part 3) 509170001111 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 509170001112 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 509170001113 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 509170001114 G1 box; other site 509170001115 GTP/Mg2+ binding site [chemical binding]; other site 509170001116 Switch I region; other site 509170001117 G2 box; other site 509170001118 G3 box; other site 509170001119 Switch II region; other site 509170001120 G4 box; other site 509170001121 G5 box; other site 509170001122 Transcriptional regulator; Region: Rrf2; cl17282 509170001123 Rrf2 family protein; Region: rrf2_super; TIGR00738 509170001124 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 509170001125 heme-binding site [chemical binding]; other site 509170001126 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 509170001127 FAD binding pocket [chemical binding]; other site 509170001128 conserved FAD binding motif [chemical binding]; other site 509170001129 phosphate binding motif [ion binding]; other site 509170001130 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of enzyme contains P-loop containing nucleotide triphosphate hydrolase domain (part 3) 509170001131 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of enzyme contains P-loop containing nucleotide triphosphate hydrolase domain (part 2) 509170001132 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of enzyme contains P-loop containing nucleotide triphosphate hydrolase domain (part 1) 509170001133 cystathionine beta-lyase; Provisional; Region: PRK07050 509170001134 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 509170001135 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 509170001136 catalytic residue [active] 509170001137 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 509170001138 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 509170001139 catalytic triad [active] 509170001140 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 509170001141 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 509170001142 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 509170001143 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 509170001144 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 509170001145 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 509170001146 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 509170001147 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 509170001148 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 509170001149 putative translocon binding site; other site 509170001150 protein-rRNA interface [nucleotide binding]; other site 509170001151 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 509170001152 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 509170001153 G-X-X-G motif; other site 509170001154 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 509170001155 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 509170001156 23S rRNA interface [nucleotide binding]; other site 509170001157 5S rRNA interface [nucleotide binding]; other site 509170001158 putative antibiotic binding site [chemical binding]; other site 509170001159 L25 interface [polypeptide binding]; other site 509170001160 L27 interface [polypeptide binding]; other site 509170001161 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 509170001162 23S rRNA interface [nucleotide binding]; other site 509170001163 putative translocon interaction site; other site 509170001164 signal recognition particle (SRP54) interaction site; other site 509170001165 L23 interface [polypeptide binding]; other site 509170001166 trigger factor interaction site; other site 509170001167 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 509170001168 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 509170001169 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 509170001170 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 509170001171 RNA binding site [nucleotide binding]; other site 509170001172 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 509170001173 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 509170001174 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 509170001175 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 509170001176 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 509170001177 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 509170001178 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 509170001179 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 509170001180 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 509170001181 5S rRNA interface [nucleotide binding]; other site 509170001182 23S rRNA interface [nucleotide binding]; other site 509170001183 L5 interface [polypeptide binding]; other site 509170001184 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 509170001185 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 509170001186 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 509170001187 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 509170001188 23S rRNA binding site [nucleotide binding]; other site 509170001189 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 509170001190 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 509170001191 SecY translocase; Region: SecY; pfam00344 509170001192 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 509170001193 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 509170001194 30S ribosomal protein S13; Region: bact_S13; TIGR03631 509170001195 30S ribosomal protein S11; Validated; Region: PRK05309 509170001196 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 509170001197 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 509170001198 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 509170001199 RNA binding surface [nucleotide binding]; other site 509170001200 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 509170001201 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 509170001202 alphaNTD homodimer interface [polypeptide binding]; other site 509170001203 alphaNTD - beta interaction site [polypeptide binding]; other site 509170001204 alphaNTD - beta' interaction site [polypeptide binding]; other site 509170001205 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 509170001206 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 509170001207 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 509170001208 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 509170001209 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 509170001210 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509170001211 active site 509170001212 Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937 509170001213 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170001214 rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902 509170001215 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 509170001216 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170001217 Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526 509170001218 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 509170001219 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 509170001220 active site 509170001221 Zn binding site [ion binding]; other site 509170001222 ribonuclease R; Region: RNase_R; TIGR02063 509170001223 RNB domain; Region: RNB; pfam00773 509170001224 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 509170001225 RNA binding site [nucleotide binding]; other site 509170001226 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170001227 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170001228 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001229 YcxB-like protein; Region: YcxB; pfam14317 509170001230 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 509170001231 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 509170001232 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 509170001233 Helix-turn-helix domain; Region: HTH_18; pfam12833 509170001234 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509170001235 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 509170001236 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 509170001237 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 509170001238 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 509170001239 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 509170001240 active site 509170001241 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 509170001242 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 509170001243 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 509170001244 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170001245 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170001246 metal-binding heat shock protein; Provisional; Region: PRK00016 509170001247 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 509170001248 PhoH-like protein; Region: PhoH; pfam02562 509170001249 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 509170001250 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 509170001251 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 509170001252 FeS/SAM binding site; other site 509170001253 TRAM domain; Region: TRAM; cl01282 509170001254 lytic murein transglycosylase; Provisional; Region: PRK11619 509170001255 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 509170001256 N-acetyl-D-glucosamine binding site [chemical binding]; other site 509170001257 catalytic residue [active] 509170001258 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 509170001259 B1 nucleotide binding pocket [chemical binding]; other site 509170001260 B2 nucleotide binding pocket [chemical binding]; other site 509170001261 CAS motifs; other site 509170001262 active site 509170001263 malate dehydrogenase; Provisional; Region: PRK05442 509170001264 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 509170001265 NAD(P) binding site [chemical binding]; other site 509170001266 dimer interface [polypeptide binding]; other site 509170001267 malate binding site [chemical binding]; other site 509170001268 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 509170001269 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 509170001270 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 509170001271 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 509170001272 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 509170001273 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 509170001274 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170001275 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001276 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 509170001277 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 509170001278 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 509170001279 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 509170001280 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170001281 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170001282 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001283 Putative phosphatase (DUF442); Region: DUF442; cl17385 509170001284 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 509170001285 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 509170001286 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 509170001287 Evidence 7 : Gene remnant; Product type c : carrier; fragment of thioredoxin C-3 (part 1) 509170001288 Evidence 7 : Gene remnant; Product type c : carrier; fragment of thioredoxin C-3 (part 2) 509170001289 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 509170001290 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 509170001291 CoenzymeA binding site [chemical binding]; other site 509170001292 subunit interaction site [polypeptide binding]; other site 509170001293 PHB binding site; other site 509170001294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 509170001295 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 509170001296 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 509170001297 active site residue [active] 509170001298 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 509170001299 Uncharacterized conserved protein [Function unknown]; Region: COG4121 509170001300 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 509170001301 YciI-like protein; Reviewed; Region: PRK11370 509170001302 Intracellular septation protein A; Region: IspA; pfam04279 509170001303 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 509170001304 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 509170001305 active site 509170001306 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 509170001307 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 509170001308 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170001309 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of DNA repair protein, associated with replication forks (RadC) (part 2) 509170001310 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of DNA repair protein, associated with replication forks (RadC) (part 1) 509170001311 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 509170001312 Flavoprotein; Region: Flavoprotein; pfam02441 509170001313 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 509170001314 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 509170001315 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 509170001316 Protein export membrane protein; Region: SecD_SecF; pfam02355 509170001317 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 509170001318 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 509170001319 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 509170001320 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 509170001321 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 509170001322 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 509170001323 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 509170001324 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170001325 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001326 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 509170001327 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 509170001328 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of sensory transduction histidine kinase (part 1) 509170001329 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of sensory transduction histidine kinase (part 2) 509170001330 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 509170001331 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 509170001332 metal binding triad; other site 509170001333 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 509170001334 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 509170001335 metal binding triad; other site 509170001336 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 509170001337 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 509170001338 homodimer interface [polypeptide binding]; other site 509170001339 substrate-cofactor binding pocket; other site 509170001340 catalytic residue [active] 509170001341 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 509170001342 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 509170001343 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 509170001344 phosphorylation site [posttranslational modification] 509170001345 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 509170001346 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 509170001347 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 509170001348 putative active site [active] 509170001349 putative metal binding site [ion binding]; other site 509170001350 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 509170001351 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 509170001352 putative metal binding site; other site 509170001353 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 509170001354 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 509170001355 putative ADP-binding pocket [chemical binding]; other site 509170001356 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 509170001357 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170001358 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001359 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of glycosyl transferase (partial) 509170001360 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 509170001361 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 509170001362 dimer interface [polypeptide binding]; other site 509170001363 anticodon binding site; other site 509170001364 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 509170001365 homodimer interface [polypeptide binding]; other site 509170001366 motif 1; other site 509170001367 active site 509170001368 motif 2; other site 509170001369 GAD domain; Region: GAD; pfam02938 509170001370 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 509170001371 active site 509170001372 motif 3; other site 509170001373 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 509170001374 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509170001375 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509170001376 N-terminal plug; other site 509170001377 ligand-binding site [chemical binding]; other site 509170001378 Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_1; cd09129 509170001379 putative active site [active] 509170001380 putative catalytic site [active] 509170001381 Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_2; cd09130 509170001382 PLD-like domain; Region: PLDc_2; pfam13091 509170001383 putative active site [active] 509170001384 putative catalytic site [active] 509170001385 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 509170001386 Predicted membrane protein [Function unknown]; Region: COG3223 509170001387 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 509170001388 C-terminal domain interface [polypeptide binding]; other site 509170001389 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 509170001390 GSH binding site (G-site) [chemical binding]; other site 509170001391 dimer interface [polypeptide binding]; other site 509170001392 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 509170001393 N-terminal domain interface [polypeptide binding]; other site 509170001394 dimer interface [polypeptide binding]; other site 509170001395 substrate binding pocket (H-site) [chemical binding]; other site 509170001396 LysR family transcriptional regulator; Provisional; Region: PRK14997 509170001397 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509170001398 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 509170001399 putative effector binding pocket; other site 509170001400 dimerization interface [polypeptide binding]; other site 509170001401 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 509170001402 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 509170001403 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509170001404 active site 509170001405 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 509170001406 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 509170001407 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 509170001408 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509170001409 active site 509170001410 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 509170001411 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 509170001412 dimerization interface [polypeptide binding]; other site 509170001413 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509170001414 dimer interface [polypeptide binding]; other site 509170001415 phosphorylation site [posttranslational modification] 509170001416 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509170001417 ATP binding site [chemical binding]; other site 509170001418 Mg2+ binding site [ion binding]; other site 509170001419 G-X-G motif; other site 509170001420 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 509170001421 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509170001422 active site 509170001423 phosphorylation site [posttranslational modification] 509170001424 intermolecular recognition site; other site 509170001425 dimerization interface [polypeptide binding]; other site 509170001426 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 509170001427 DNA binding site [nucleotide binding] 509170001428 Uncharacterized conserved protein [Function unknown]; Region: COG0397 509170001429 hypothetical protein; Validated; Region: PRK00029 509170001430 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 509170001431 Fatty acid desaturase; Region: FA_desaturase; pfam00487 509170001432 Di-iron ligands [ion binding]; other site 509170001433 META domain; Region: META; pfam03724 509170001434 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of glycerophosphodiester phosphodiesterase (part 2) 509170001435 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170001436 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001437 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of glycerophosphodiester phosphodiesterase (part 1) 509170001438 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 509170001439 Evidence 7 : Gene remnant; Product type t : transporter; fragment of TonB-dependent Outer membrane receptor for vitamin B12/cobalamin transport (Btub) (part 3) 509170001440 Evidence 7 : Gene remnant; Product type t : transporter; fragment of TonB-dependent Outer membrane receptor for vitamin B12/cobalamin transport (Btub) (part 2) 509170001441 Evidence 7 : Gene remnant; Product type t : transporter; fragment of TonB-dependent Outer membrane receptor for vitamin B12/cobalamin transport (Btub) (part 1) 509170001442 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 509170001443 active site 509170001444 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 509170001445 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 509170001446 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170001447 catalytic residue [active] 509170001448 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170001449 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170001450 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 509170001451 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 509170001452 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 509170001453 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 509170001454 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 509170001455 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 509170001456 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 509170001457 substrate binding site [chemical binding]; other site 509170001458 active site 509170001459 catalytic residues [active] 509170001460 heterodimer interface [polypeptide binding]; other site 509170001461 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 509170001462 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 509170001463 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 509170001464 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 509170001465 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 509170001466 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 509170001467 active site 509170001468 catalytic residues [active] 509170001469 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 509170001470 Evidence 7 : Gene remnant; Product type ph : phenotype; fragment of antioxidant protein (part 2) 509170001471 Evidence 7 : Gene remnant; Product type ph : phenotype; fragment of antioxidant protein (part 1) 509170001472 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170001473 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001474 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 509170001475 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 509170001476 SEC-C motif; Region: SEC-C; pfam02810 509170001477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170001478 metabolite-proton symporter; Region: 2A0106; TIGR00883 509170001479 putative substrate translocation pore; other site 509170001480 Haemolysin-III related; Region: HlyIII; cl03831 509170001481 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 509170001482 Methyltransferase domain; Region: Methyltransf_31; pfam13847 509170001483 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509170001484 S-adenosylmethionine binding site [chemical binding]; other site 509170001485 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 509170001486 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 509170001487 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 509170001488 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 509170001489 active site 509170001490 nucleophile elbow; other site 509170001491 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 509170001492 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 509170001493 substrate binding site [chemical binding]; other site 509170001494 oxyanion hole (OAH) forming residues; other site 509170001495 trimer interface [polypeptide binding]; other site 509170001496 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 509170001497 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 509170001498 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 509170001499 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 509170001500 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 509170001501 dimer interface [polypeptide binding]; other site 509170001502 active site 509170001503 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 509170001504 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 509170001505 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509170001506 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170001507 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001508 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 509170001509 CoA-transferase family III; Region: CoA_transf_3; pfam02515 509170001510 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 509170001511 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 509170001512 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 509170001513 Trp docking motif [polypeptide binding]; other site 509170001514 putative active site [active] 509170001515 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 509170001516 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 509170001517 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 509170001518 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 509170001519 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 509170001520 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170001521 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001522 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170001523 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 509170001524 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 509170001525 dimer interface [polypeptide binding]; other site 509170001526 active site 509170001527 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170001528 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001529 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 509170001530 Type II transport protein GspH; Region: GspH; pfam12019 509170001531 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 509170001532 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 509170001533 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 509170001534 ligand binding site [chemical binding]; other site 509170001535 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170001536 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170001537 lysine transporter; Provisional; Region: PRK10836 509170001538 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 509170001539 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 509170001540 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509170001541 S-adenosylmethionine binding site [chemical binding]; other site 509170001542 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 509170001543 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 509170001544 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 509170001545 G1 box; other site 509170001546 putative GEF interaction site [polypeptide binding]; other site 509170001547 GTP/Mg2+ binding site [chemical binding]; other site 509170001548 Switch I region; other site 509170001549 G2 box; other site 509170001550 G3 box; other site 509170001551 Switch II region; other site 509170001552 G4 box; other site 509170001553 G5 box; other site 509170001554 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 509170001555 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 509170001556 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 509170001557 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 509170001558 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 509170001559 putative active site pocket [active] 509170001560 dimerization interface [polypeptide binding]; other site 509170001561 putative catalytic residue [active] 509170001562 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 509170001563 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 509170001564 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 509170001565 DNA binding site [nucleotide binding] 509170001566 catalytic residue [active] 509170001567 H2TH interface [polypeptide binding]; other site 509170001568 putative catalytic residues [active] 509170001569 turnover-facilitating residue; other site 509170001570 intercalation triad [nucleotide binding]; other site 509170001571 8OG recognition residue [nucleotide binding]; other site 509170001572 putative reading head residues; other site 509170001573 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 509170001574 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 509170001575 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 509170001576 active site 509170001577 DNA binding site [nucleotide binding] 509170001578 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509170001579 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509170001580 N-terminal plug; other site 509170001581 ligand-binding site [chemical binding]; other site 509170001582 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of FMN oxidoreductase (part 1) 509170001583 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of FMN oxidoreductase (part 2) 509170001584 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of transporter (part 1) 509170001585 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of transporter (part 2) 509170001586 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 509170001587 Sel1-like repeats; Region: SEL1; smart00671 509170001588 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 509170001589 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 509170001590 dimerization domain [polypeptide binding]; other site 509170001591 dimer interface [polypeptide binding]; other site 509170001592 catalytic residues [active] 509170001593 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170001594 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170001595 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 509170001596 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 509170001597 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 509170001598 putative hydrophobic ligand binding site [chemical binding]; other site 509170001599 Uncharacterized conserved protein [Function unknown]; Region: COG3189 509170001600 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 509170001601 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 509170001602 PhnA protein; Region: PhnA; pfam03831 509170001603 Uncharacterized conserved protein [Function unknown]; Region: COG3422 509170001604 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 509170001605 prolyl-tRNA synthetase; Provisional; Region: PRK09194 509170001606 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 509170001607 dimer interface [polypeptide binding]; other site 509170001608 motif 1; other site 509170001609 active site 509170001610 motif 2; other site 509170001611 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 509170001612 putative deacylase active site [active] 509170001613 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 509170001614 active site 509170001615 motif 3; other site 509170001616 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 509170001617 anticodon binding site; other site 509170001618 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 509170001619 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 509170001620 HlyD family secretion protein; Region: HlyD_3; pfam13437 509170001621 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170001622 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170001623 Response regulator receiver domain; Region: Response_reg; pfam00072 509170001624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509170001625 active site 509170001626 phosphorylation site [posttranslational modification] 509170001627 intermolecular recognition site; other site 509170001628 dimerization interface [polypeptide binding]; other site 509170001629 Response regulator receiver domain; Region: Response_reg; pfam00072 509170001630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509170001631 active site 509170001632 phosphorylation site [posttranslational modification] 509170001633 intermolecular recognition site; other site 509170001634 dimerization interface [polypeptide binding]; other site 509170001635 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 509170001636 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 509170001637 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 509170001638 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 509170001639 dimer interface [polypeptide binding]; other site 509170001640 putative CheW interface [polypeptide binding]; other site 509170001641 Evidence 7 : Gene remnant; Product type r : regulator; fragment of component of chemotactic signal transduction system (part 1) 509170001642 Evidence 7 : Gene remnant; Product type r : regulator; fragment of component of chemotactic signal transduction system (part 2) 509170001643 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 509170001644 active site 509170001645 dimerization interface [polypeptide binding]; other site 509170001646 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170001647 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001648 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 509170001649 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 509170001650 metal binding site [ion binding]; metal-binding site 509170001651 dimer interface [polypeptide binding]; other site 509170001652 Predicted small secreted protein [Function unknown]; Region: COG5510 509170001653 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170001654 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170001655 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170001656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 509170001657 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 509170001658 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 509170001659 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170001660 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001661 Uncharacterized conserved protein [Function unknown]; Region: COG1434 509170001662 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 509170001663 putative active site [active] 509170001664 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 509170001665 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 509170001666 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 509170001667 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 509170001668 Flavodoxin; Region: Flavodoxin_1; pfam00258 509170001669 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 509170001670 FAD binding pocket [chemical binding]; other site 509170001671 FAD binding motif [chemical binding]; other site 509170001672 catalytic residues [active] 509170001673 NAD binding pocket [chemical binding]; other site 509170001674 phosphate binding motif [ion binding]; other site 509170001675 beta-alpha-beta structure motif; other site 509170001676 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 509170001677 YcxB-like protein; Region: YcxB; pfam14317 509170001678 TIGR01666 family membrane protein; Region: YCCS 509170001679 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 509170001680 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 509170001681 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 509170001682 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170001683 putative substrate translocation pore; other site 509170001684 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of nitroreductase (part 2) 509170001685 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of nitroreductase (part 1) 509170001686 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170001687 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001688 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170001689 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001690 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of amino-acid transport protein (part 1) 509170001691 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of amino-acid transport protein (part 2) 509170001692 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 509170001693 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 509170001694 active site 509170001695 nucleophile elbow; other site 509170001696 threonine dehydratase; Provisional; Region: PRK07334 509170001697 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 509170001698 tetramer interface [polypeptide binding]; other site 509170001699 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170001700 catalytic residue [active] 509170001701 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 509170001702 microcin B17 transporter; Reviewed; Region: PRK11098 509170001703 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 509170001704 intracellular protease, PfpI family; Region: PfpI; TIGR01382 509170001705 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 509170001706 conserved cys residue [active] 509170001707 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 509170001708 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 509170001709 GatB domain; Region: GatB_Yqey; smart00845 509170001710 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 509170001711 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 509170001712 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 509170001713 rod shape-determining protein MreB; Provisional; Region: PRK13927 509170001714 MreB and similar proteins; Region: MreB_like; cd10225 509170001715 nucleotide binding site [chemical binding]; other site 509170001716 Mg binding site [ion binding]; other site 509170001717 putative protofilament interaction site [polypeptide binding]; other site 509170001718 RodZ interaction site [polypeptide binding]; other site 509170001719 rod shape-determining protein MreC; Provisional; Region: PRK13922 509170001720 rod shape-determining protein MreC; Region: MreC; pfam04085 509170001721 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 509170001722 Maf-like protein; Region: Maf; pfam02545 509170001723 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 509170001724 active site 509170001725 dimer interface [polypeptide binding]; other site 509170001726 ribonuclease G; Provisional; Region: PRK11712 509170001727 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 509170001728 homodimer interface [polypeptide binding]; other site 509170001729 oligonucleotide binding site [chemical binding]; other site 509170001730 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 509170001731 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 509170001732 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 509170001733 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 509170001734 Active Sites [active] 509170001735 phosphoserine phosphatase; Provisional; Region: thrH; PRK13582 509170001736 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 509170001737 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 509170001738 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 509170001739 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 509170001740 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of HTH-type transcriptional regulator (AraC family) (part 1) 509170001741 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170001742 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001743 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of HTH-type transcriptional regulator (AraC family) (part 2) 509170001744 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 509170001745 putative di-iron ligands [ion binding]; other site 509170001746 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 509170001747 Mrr N-terminal domain; Region: Mrr_N; pfam14338 509170001748 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 509170001749 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 509170001750 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 509170001751 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509170001752 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 509170001753 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509170001754 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 509170001755 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 509170001756 NAD(P) binding site [chemical binding]; other site 509170001757 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170001758 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170001759 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 509170001760 catalytic site [active] 509170001761 Asp-box motif; other site 509170001762 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; COG3808 509170001763 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 509170001764 catalytic residues [active] 509170001765 PAAR motif; Region: PAAR_motif; pfam05488 509170001766 integrase; Provisional; Region: PRK09692 509170001767 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 509170001768 active site 509170001769 Int/Topo IB signature motif; other site 509170001770 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 509170001771 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 509170001772 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 509170001773 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 509170001774 substrate binding pocket [chemical binding]; other site 509170001775 chain length determination region; other site 509170001776 substrate-Mg2+ binding site; other site 509170001777 catalytic residues [active] 509170001778 aspartate-rich region 1; other site 509170001779 active site lid residues [active] 509170001780 aspartate-rich region 2; other site 509170001781 Protein of unknown function (DUF419); Region: DUF419; cl15265 509170001782 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 509170001783 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 509170001784 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 509170001785 hypothetical protein; Provisional; Region: PRK10279 509170001786 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 509170001787 nucleophile elbow; other site 509170001788 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 509170001789 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 509170001790 putative acyl-acceptor binding pocket; other site 509170001791 muropeptide transporter; Validated; Region: ampG; cl17669 509170001792 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170001793 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170001794 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170001795 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170001796 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509170001797 S-adenosylmethionine binding site [chemical binding]; other site 509170001798 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 509170001799 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 509170001800 HIGH motif; other site 509170001801 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 509170001802 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 509170001803 active site 509170001804 KMSKS motif; other site 509170001805 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 509170001806 tRNA binding surface [nucleotide binding]; other site 509170001807 anticodon binding site; other site 509170001808 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 509170001809 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170001810 short chain dehydrogenase; Provisional; Region: PRK06181 509170001811 NAD(P) binding site [chemical binding]; other site 509170001812 active site 509170001813 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170001814 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170001815 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001816 Uncharacterized conserved protein [Function unknown]; Region: COG0393 509170001817 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 509170001818 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 509170001819 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 509170001820 Protein export membrane protein; Region: SecD_SecF; cl14618 509170001821 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 509170001822 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 509170001823 HlyD family secretion protein; Region: HlyD_3; pfam13437 509170001824 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 509170001825 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 509170001826 active site 509170001827 Site-specific recombinase; Region: SpecificRecomb; pfam10136 509170001828 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 509170001829 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 509170001830 substrate binding pocket [chemical binding]; other site 509170001831 chain length determination region; other site 509170001832 substrate-Mg2+ binding site; other site 509170001833 catalytic residues [active] 509170001834 aspartate-rich region 1; other site 509170001835 active site lid residues [active] 509170001836 aspartate-rich region 2; other site 509170001837 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 509170001838 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 509170001839 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 509170001840 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 509170001841 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 509170001842 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 509170001843 seryl-tRNA synthetase; Provisional; Region: PRK05431 509170001844 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 509170001845 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 509170001846 dimer interface [polypeptide binding]; other site 509170001847 active site 509170001848 motif 1; other site 509170001849 motif 2; other site 509170001850 motif 3; other site 509170001851 siroheme synthase; Provisional; Region: cysG; PRK10637 509170001852 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 509170001853 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 509170001854 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 509170001855 active site 509170001856 SAM binding site [chemical binding]; other site 509170001857 homodimer interface [polypeptide binding]; other site 509170001858 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 509170001859 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170001860 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170001861 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001862 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170001863 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170001864 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170001865 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 509170001866 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 509170001867 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH5; cd08189 509170001868 putative active site [active] 509170001869 metal binding site [ion binding]; metal-binding site 509170001870 lipoate-protein ligase B; Provisional; Region: PRK14342 509170001871 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170001872 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001873 Protein of unknown function (DUF493); Region: DUF493; pfam04359 509170001874 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 509170001875 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 509170001876 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 509170001877 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 509170001878 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 509170001879 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509170001880 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 509170001881 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 509170001882 DNA binding residues [nucleotide binding] 509170001883 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 509170001884 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170001885 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170001886 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 509170001887 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 509170001888 active site residue [active] 509170001889 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 509170001890 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 509170001891 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 509170001892 dimer interface [polypeptide binding]; other site 509170001893 active site 509170001894 citrylCoA binding site [chemical binding]; other site 509170001895 NADH binding [chemical binding]; other site 509170001896 cationic pore residues; other site 509170001897 oxalacetate/citrate binding site [chemical binding]; other site 509170001898 coenzyme A binding site [chemical binding]; other site 509170001899 catalytic triad [active] 509170001900 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 509170001901 Iron-sulfur protein interface; other site 509170001902 proximal quinone binding site [chemical binding]; other site 509170001903 SdhD (CybS) interface [polypeptide binding]; other site 509170001904 proximal heme binding site [chemical binding]; other site 509170001905 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 509170001906 SdhC subunit interface [polypeptide binding]; other site 509170001907 proximal heme binding site [chemical binding]; other site 509170001908 cardiolipin binding site; other site 509170001909 Iron-sulfur protein interface; other site 509170001910 proximal quinone binding site [chemical binding]; other site 509170001911 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 509170001912 L-aspartate oxidase; Provisional; Region: PRK06175 509170001913 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 509170001914 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 509170001915 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 509170001916 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 509170001917 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 509170001918 TPP-binding site [chemical binding]; other site 509170001919 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 509170001920 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 509170001921 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 509170001922 E3 interaction surface; other site 509170001923 lipoyl attachment site [posttranslational modification]; other site 509170001924 e3 binding domain; Region: E3_binding; pfam02817 509170001925 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 509170001926 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 509170001927 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 509170001928 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 509170001929 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 509170001930 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 509170001931 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 509170001932 CoA-ligase; Region: Ligase_CoA; pfam00549 509170001933 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 509170001934 CoA binding domain; Region: CoA_binding; smart00881 509170001935 CoA-ligase; Region: Ligase_CoA; pfam00549 509170001936 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170001937 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170001938 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 509170001939 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 509170001940 active site 509170001941 HIGH motif; other site 509170001942 dimer interface [polypeptide binding]; other site 509170001943 KMSKS motif; other site 509170001944 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170001945 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170001946 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001947 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 509170001948 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 509170001949 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 509170001950 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 509170001951 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 509170001952 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 509170001953 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 509170001954 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 509170001955 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 509170001956 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 509170001957 ATP-grasp domain; Region: ATP-grasp_4; cl17255 509170001958 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 509170001959 IMP binding site; other site 509170001960 dimer interface [polypeptide binding]; other site 509170001961 interdomain contacts; other site 509170001962 partial ornithine binding site; other site 509170001963 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 509170001964 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 509170001965 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 509170001966 catalytic site [active] 509170001967 subunit interface [polypeptide binding]; other site 509170001968 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170001969 Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627 509170001970 putative heme binding site [chemical binding]; other site 509170001971 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 509170001972 FtsJ-like methyltransferase; Region: FtsJ; cl17430 509170001973 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 509170001974 FtsH Extracellular; Region: FtsH_ext; pfam06480 509170001975 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 509170001976 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170001977 Walker A motif; other site 509170001978 ATP binding site [chemical binding]; other site 509170001979 Walker B motif; other site 509170001980 arginine finger; other site 509170001981 Peptidase family M41; Region: Peptidase_M41; pfam01434 509170001982 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 509170001983 dihydropteroate synthase; Region: DHPS; TIGR01496 509170001984 substrate binding pocket [chemical binding]; other site 509170001985 dimer interface [polypeptide binding]; other site 509170001986 inhibitor binding site; inhibition site 509170001987 PhoD-like phosphatase; Region: PhoD; pfam09423 509170001988 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 509170001989 putative active site [active] 509170001990 putative metal binding site [ion binding]; other site 509170001991 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 509170001992 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14192 509170001993 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 509170001994 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 509170001995 homodimer interface [polypeptide binding]; other site 509170001996 NADP binding site [chemical binding]; other site 509170001997 substrate binding site [chemical binding]; other site 509170001998 Predicted methyltransferase [General function prediction only]; Region: COG3897 509170001999 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509170002000 S-adenosylmethionine binding site [chemical binding]; other site 509170002001 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 509170002002 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170002003 putative substrate translocation pore; other site 509170002004 glycerol kinase; Provisional; Region: glpK; PRK00047 509170002005 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 509170002006 N- and C-terminal domain interface [polypeptide binding]; other site 509170002007 active site 509170002008 MgATP binding site [chemical binding]; other site 509170002009 catalytic site [active] 509170002010 metal binding site [ion binding]; metal-binding site 509170002011 glycerol binding site [chemical binding]; other site 509170002012 homotetramer interface [polypeptide binding]; other site 509170002013 homodimer interface [polypeptide binding]; other site 509170002014 FBP binding site [chemical binding]; other site 509170002015 protein IIAGlc interface [polypeptide binding]; other site 509170002016 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 509170002017 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 509170002018 active site 509170002019 substrate-binding site [chemical binding]; other site 509170002020 metal-binding site [ion binding] 509170002021 GTP binding site [chemical binding]; other site 509170002022 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170002023 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170002024 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002025 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170002026 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170002027 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 3) 509170002028 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 4) 509170002029 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 509170002030 oligomerisation interface [polypeptide binding]; other site 509170002031 mobile loop; other site 509170002032 roof hairpin; other site 509170002033 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 509170002034 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 509170002035 ring oligomerisation interface [polypeptide binding]; other site 509170002036 ATP/Mg binding site [chemical binding]; other site 509170002037 stacking interactions; other site 509170002038 hinge regions; other site 509170002039 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 509170002040 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 509170002041 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 509170002042 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 509170002043 putative active site [active] 509170002044 catalytic site [active] 509170002045 putative metal binding site [ion binding]; other site 509170002046 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of multidrug efflux protein (part 1) 509170002047 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of multidrug efflux protein (part 2) 509170002048 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170002049 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002050 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of multidrug efflux protein (part 3) 509170002051 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of multidrug efflux protein (part 4) 509170002052 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 509170002053 heat shock protein HtpX; Provisional; Region: PRK05457 509170002054 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 509170002055 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 509170002056 N-acetyl-D-glucosamine binding site [chemical binding]; other site 509170002057 catalytic residue [active] 509170002058 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 509170002059 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 509170002060 Ligand Binding Site [chemical binding]; other site 509170002061 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170002062 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170002063 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170002064 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002065 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170002066 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170002067 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170002068 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002069 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 509170002070 dimer interface [polypeptide binding]; other site 509170002071 FMN binding site [chemical binding]; other site 509170002072 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 509170002073 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170002074 NAD(P) binding site [chemical binding]; other site 509170002075 active site 509170002076 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509170002077 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509170002078 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of Glycerate kinase (partial) 509170002079 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170002080 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002081 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 509170002082 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 509170002083 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 509170002084 ligand binding site [chemical binding]; other site 509170002085 NAD binding site [chemical binding]; other site 509170002086 catalytic site [active] 509170002087 homodimer interface [polypeptide binding]; other site 509170002088 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 509170002089 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 509170002090 motif 1; other site 509170002091 dimer interface [polypeptide binding]; other site 509170002092 active site 509170002093 motif 2; other site 509170002094 motif 3; other site 509170002095 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 509170002096 DNA repair protein RadA; Provisional; Region: PRK11823 509170002097 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 509170002098 Walker A motif/ATP binding site; other site 509170002099 ATP binding site [chemical binding]; other site 509170002100 Walker B motif; other site 509170002101 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 509170002102 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 509170002103 diaminopimelate decarboxylase; Region: lysA; TIGR01048 509170002104 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 509170002105 active site 509170002106 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 509170002107 substrate binding site [chemical binding]; other site 509170002108 catalytic residues [active] 509170002109 dimer interface [polypeptide binding]; other site 509170002110 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 509170002111 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 509170002112 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 509170002113 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 509170002114 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 509170002115 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 509170002116 catalytic site [active] 509170002117 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170002118 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002119 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of LysE family transpoter (part 2) 509170002120 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of LysE family transporter (part 1) 509170002121 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 509170002122 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 509170002123 active site 509170002124 DNA binding site [nucleotide binding] 509170002125 Int/Topo IB signature motif; other site 509170002126 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 509170002127 Ligand binding site [chemical binding]; other site 509170002128 Electron transfer flavoprotein domain; Region: ETF; pfam01012 509170002129 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 509170002130 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 509170002131 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 509170002132 DNA gyrase subunit A; Validated; Region: PRK05560 509170002133 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 509170002134 CAP-like domain; other site 509170002135 active site 509170002136 primary dimer interface [polypeptide binding]; other site 509170002137 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 509170002138 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 509170002139 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 509170002140 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 509170002141 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 509170002142 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 509170002143 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 3) 509170002144 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170002145 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170002146 GtrA-like protein; Region: GtrA; pfam04138 509170002147 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of CPS-53 prophage, bactoprenol glucosyl transferase (part 2) 509170002148 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170002149 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002150 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of CPS-53 prophage, bactoprenol glucosyl transferase (part 1) 509170002151 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 509170002152 putative active site [active] 509170002153 YdjC motif; other site 509170002154 Mg binding site [ion binding]; other site 509170002155 putative homodimer interface [polypeptide binding]; other site 509170002156 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 509170002157 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 509170002158 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 509170002159 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 509170002160 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 509170002161 HlyD family secretion protein; Region: HlyD_3; pfam13437 509170002162 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 509170002163 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 509170002164 homodimer interface [polypeptide binding]; other site 509170002165 substrate-cofactor binding pocket; other site 509170002166 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170002167 catalytic residue [active] 509170002168 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170002169 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002170 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 509170002171 EamA-like transporter family; Region: EamA; pfam00892 509170002172 EamA-like transporter family; Region: EamA; cl17759 509170002173 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 509170002174 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 509170002175 FtsX-like permease family; Region: FtsX; pfam02687 509170002176 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 509170002177 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 509170002178 Walker A/P-loop; other site 509170002179 ATP binding site [chemical binding]; other site 509170002180 Q-loop/lid; other site 509170002181 ABC transporter signature motif; other site 509170002182 Walker B; other site 509170002183 D-loop; other site 509170002184 H-loop/switch region; other site 509170002185 Evidence 7 : Gene remnant; Product type f : factor; fragment of Competence factor involved in DNA uptake (part 1) 509170002186 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170002187 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170002188 Evidence 7 : Gene remnant; Product type f : factor; fragment of competence factor involved in DNA uptake (part 1) 509170002189 Evidence 7 : Gene remnant; Product type f : factor; fragment of competence factor involved in DNA uptake (part 2) 509170002190 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 509170002191 putative acyl-acceptor binding pocket; other site 509170002192 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 509170002193 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 509170002194 tandem repeat interface [polypeptide binding]; other site 509170002195 oligomer interface [polypeptide binding]; other site 509170002196 active site residues [active] 509170002197 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of hydrolase (part 1) 509170002198 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of hydrolase (part 2) 509170002199 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170002200 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002201 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 509170002202 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 509170002203 active site 509170002204 substrate binding site [chemical binding]; other site 509170002205 cosubstrate binding site; other site 509170002206 catalytic site [active] 509170002207 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 509170002208 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 509170002209 dimerization interface [polypeptide binding]; other site 509170002210 putative ATP binding site [chemical binding]; other site 509170002211 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 509170002212 Domain of unknown function DUF20; Region: UPF0118; pfam01594 509170002213 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 509170002214 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170002215 Walker A motif; other site 509170002216 ATP binding site [chemical binding]; other site 509170002217 Walker B motif; other site 509170002218 arginine finger; other site 509170002219 Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212 509170002220 CSLREA domain; Region: CSLREA_Nterm; TIGR04214 509170002221 CSLREA domain; Region: CSLREA_Nterm; TIGR04214 509170002222 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170002223 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002224 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 509170002225 RNA polymerase factor sigma-70; Validated; Region: PRK09047 509170002226 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509170002227 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 509170002228 DNA binding residues [nucleotide binding] 509170002229 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 509170002230 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 509170002231 fructose-1,6-bisphosphatase family protein; Region: PLN02628 509170002232 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 509170002233 AMP binding site [chemical binding]; other site 509170002234 metal binding site [ion binding]; metal-binding site 509170002235 active site 509170002236 putative outer membrane lipoprotein; Provisional; Region: PRK09967 509170002237 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 509170002238 ligand binding site [chemical binding]; other site 509170002239 translocation protein TolB; Provisional; Region: tolB; PRK04922 509170002240 TolB amino-terminal domain; Region: TolB_N; pfam04052 509170002241 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 509170002242 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 509170002243 TolA protein; Region: tolA_full; TIGR02794 509170002244 TonB C terminal; Region: TonB_2; pfam13103 509170002245 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 509170002246 TolR protein; Region: tolR; TIGR02801 509170002247 TolQ protein; Region: tolQ; TIGR02796 509170002248 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 509170002249 active site 509170002250 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of hydrolase (part 2) 509170002251 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of hydrolase (part 1) 509170002252 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 509170002253 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 509170002254 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170002255 Walker A motif; other site 509170002256 ATP binding site [chemical binding]; other site 509170002257 Walker B motif; other site 509170002258 arginine finger; other site 509170002259 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 509170002260 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 509170002261 RuvA N terminal domain; Region: RuvA_N; pfam01330 509170002262 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 509170002263 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 509170002264 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 509170002265 Zn2+ binding site [ion binding]; other site 509170002266 Mg2+ binding site [ion binding]; other site 509170002267 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 509170002268 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 509170002269 dimerization interface [polypeptide binding]; other site 509170002270 ATP binding site [chemical binding]; other site 509170002271 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 509170002272 dimerization interface [polypeptide binding]; other site 509170002273 ATP binding site [chemical binding]; other site 509170002274 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 509170002275 putative active site [active] 509170002276 catalytic triad [active] 509170002277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170002278 putative substrate translocation pore; other site 509170002279 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 509170002280 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170002281 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002282 enoyl-CoA hydratase; Provisional; Region: PRK06688 509170002283 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 509170002284 substrate binding site [chemical binding]; other site 509170002285 oxyanion hole (OAH) forming residues; other site 509170002286 trimer interface [polypeptide binding]; other site 509170002287 nicotinamide-nucleotide adenylyltransferase; Provisional; Region: PRK13793 509170002288 active site 509170002289 nucleotide binding site [chemical binding]; other site 509170002290 HIGH motif; other site 509170002291 KMSKS motif; other site 509170002292 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 509170002293 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 509170002294 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 509170002295 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 509170002296 catalytic triad [active] 509170002297 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170002298 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170002299 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002300 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170002301 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 509170002302 Ligand Binding Site [chemical binding]; other site 509170002303 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 509170002304 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 509170002305 FeS/SAM binding site; other site 509170002306 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 509170002307 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 509170002308 active site 509170002309 substrate binding site [chemical binding]; other site 509170002310 trimer interface [polypeptide binding]; other site 509170002311 CoA binding site [chemical binding]; other site 509170002312 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683 509170002313 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509170002314 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 509170002315 substrate binding site [chemical binding]; other site 509170002316 dimerization interface [polypeptide binding]; other site 509170002317 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 509170002318 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 509170002319 Walker A/P-loop; other site 509170002320 ATP binding site [chemical binding]; other site 509170002321 Q-loop/lid; other site 509170002322 ABC transporter signature motif; other site 509170002323 Walker B; other site 509170002324 D-loop; other site 509170002325 H-loop/switch region; other site 509170002326 TOBE-like domain; Region: TOBE_3; pfam12857 509170002327 sulfate transport protein; Provisional; Region: cysT; CHL00187 509170002328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 509170002329 dimer interface [polypeptide binding]; other site 509170002330 conserved gate region; other site 509170002331 putative PBP binding loops; other site 509170002332 ABC-ATPase subunit interface; other site 509170002333 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 509170002334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 509170002335 dimer interface [polypeptide binding]; other site 509170002336 conserved gate region; other site 509170002337 putative PBP binding loops; other site 509170002338 ABC-ATPase subunit interface; other site 509170002339 Serine hydrolase; Region: Ser_hydrolase; pfam06821 509170002340 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 509170002341 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 509170002342 substrate binding pocket [chemical binding]; other site 509170002343 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 509170002344 membrane-bound complex binding site; other site 509170002345 hinge residues; other site 509170002346 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 509170002347 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 509170002348 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170002349 catalytic residue [active] 509170002350 YceG-like family; Region: YceG; pfam02618 509170002351 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 509170002352 dimerization interface [polypeptide binding]; other site 509170002353 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 509170002354 thymidylate kinase; Validated; Region: tmk; PRK00698 509170002355 TMP-binding site; other site 509170002356 ATP-binding site [chemical binding]; other site 509170002357 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 509170002358 CoenzymeA binding site [chemical binding]; other site 509170002359 subunit interaction site [polypeptide binding]; other site 509170002360 PHB binding site; other site 509170002361 L-aspartate oxidase; Provisional; Region: PRK09077 509170002362 L-aspartate oxidase; Provisional; Region: PRK06175 509170002363 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 509170002364 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 509170002365 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 509170002366 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 509170002367 protein binding site [polypeptide binding]; other site 509170002368 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 509170002369 protein binding site [polypeptide binding]; other site 509170002370 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170002371 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002372 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 509170002373 active site 509170002374 GTP-binding protein LepA; Provisional; Region: PRK05433 509170002375 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 509170002376 G1 box; other site 509170002377 putative GEF interaction site [polypeptide binding]; other site 509170002378 GTP/Mg2+ binding site [chemical binding]; other site 509170002379 Switch I region; other site 509170002380 G2 box; other site 509170002381 G3 box; other site 509170002382 Switch II region; other site 509170002383 G4 box; other site 509170002384 G5 box; other site 509170002385 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 509170002386 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 509170002387 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 509170002388 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 509170002389 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 509170002390 Catalytic site [active] 509170002391 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 509170002392 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 509170002393 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 509170002394 dimerization interface [polypeptide binding]; other site 509170002395 active site 509170002396 metal binding site [ion binding]; metal-binding site 509170002397 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 509170002398 dsRNA binding site [nucleotide binding]; other site 509170002399 GTPase Era; Reviewed; Region: era; PRK00089 509170002400 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 509170002401 G1 box; other site 509170002402 GTP/Mg2+ binding site [chemical binding]; other site 509170002403 Switch I region; other site 509170002404 G2 box; other site 509170002405 Switch II region; other site 509170002406 G3 box; other site 509170002407 G4 box; other site 509170002408 G5 box; other site 509170002409 KH domain; Region: KH_2; pfam07650 509170002410 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 509170002411 Recombination protein O N terminal; Region: RecO_N; pfam11967 509170002412 Recombination protein O C terminal; Region: RecO_C; pfam02565 509170002413 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 509170002414 active site 509170002415 hydrophilic channel; other site 509170002416 dimerization interface [polypeptide binding]; other site 509170002417 catalytic residues [active] 509170002418 active site lid [active] 509170002419 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 509170002420 active site 509170002421 dinuclear metal binding site [ion binding]; other site 509170002422 dimerization interface [polypeptide binding]; other site 509170002423 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170002424 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170002425 malonic semialdehyde reductase; Provisional; Region: PRK10538 509170002426 NAD(P) binding site [chemical binding]; other site 509170002427 active site 509170002428 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170002429 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170002430 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002431 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170002432 Uncharacterized conserved protein [Function unknown]; Region: COG3791 509170002433 aspartate aminotransferase; Provisional; Region: PRK05764 509170002434 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 509170002435 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170002436 homodimer interface [polypeptide binding]; other site 509170002437 catalytic residue [active] 509170002438 PAS domain; Region: PAS_9; pfam13426 509170002439 PAS domain; Region: PAS_9; pfam13426 509170002440 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 509170002441 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 509170002442 metal binding site [ion binding]; metal-binding site 509170002443 active site 509170002444 I-site; other site 509170002445 hypothetical protein; Region: PHA00684 509170002446 excinuclease ABC subunit B; Provisional; Region: PRK05298 509170002447 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 509170002448 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 509170002449 ATP-binding site [chemical binding]; other site 509170002450 ATP binding site [chemical binding]; other site 509170002451 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 509170002452 nucleotide binding region [chemical binding]; other site 509170002453 ATP-binding site [chemical binding]; other site 509170002454 Ultra-violet resistance protein B; Region: UvrB; pfam12344 509170002455 UvrB/uvrC motif; Region: UVR; pfam02151 509170002456 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 509170002457 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 509170002458 Evidence 7 : Gene remnant; Product type m : membrane component; fragment of chloramphenicol-sensitive protein (part 1) 509170002459 Evidence 7 : Gene remnant; Product type m : membrane component; fragment of chloramphenicol-sensitive protein (part 2) 509170002460 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 509170002461 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 509170002462 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 509170002463 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170002464 GTPase CgtA; Reviewed; Region: obgE; PRK12298 509170002465 GTP1/OBG; Region: GTP1_OBG; pfam01018 509170002466 Obg GTPase; Region: Obg; cd01898 509170002467 G1 box; other site 509170002468 GTP/Mg2+ binding site [chemical binding]; other site 509170002469 Switch I region; other site 509170002470 G2 box; other site 509170002471 G3 box; other site 509170002472 Switch II region; other site 509170002473 G4 box; other site 509170002474 G5 box; other site 509170002475 gamma-glutamyl kinase; Provisional; Region: PRK05429 509170002476 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 509170002477 nucleotide binding site [chemical binding]; other site 509170002478 homotetrameric interface [polypeptide binding]; other site 509170002479 putative phosphate binding site [ion binding]; other site 509170002480 putative allosteric binding site; other site 509170002481 PUA domain; Region: PUA; pfam01472 509170002482 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 509170002483 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 509170002484 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 509170002485 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 509170002486 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 509170002487 FMN binding site [chemical binding]; other site 509170002488 active site 509170002489 catalytic residues [active] 509170002490 substrate binding site [chemical binding]; other site 509170002491 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 509170002492 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 509170002493 FMN binding site [chemical binding]; other site 509170002494 substrate binding site [chemical binding]; other site 509170002495 putative catalytic residue [active] 509170002496 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 509170002497 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170002498 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of deoxyribodipyrimidine photolyase (photoreactivation), FAD-binding (partial) 509170002499 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 509170002500 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 509170002501 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of NADH dehydrogenase II (part 2) 509170002502 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of NADH dehydrogenase II (part 1) 509170002503 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170002504 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002505 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 509170002506 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 509170002507 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 509170002508 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 509170002509 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 509170002510 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 509170002511 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 509170002512 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 509170002513 pseudouridine synthase; Region: TIGR00093 509170002514 probable active site [active] 509170002515 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 509170002516 ERF superfamily; Region: ERF; pfam04404 509170002517 replicative DNA helicase; Provisional; Region: PRK08840 509170002518 hypothetical protein; Provisional; Region: PRK09946 509170002519 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 509170002520 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 509170002521 Domain of unknown function (DUF955); Region: DUF955; cl01076 509170002522 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 509170002523 non-specific DNA binding site [nucleotide binding]; other site 509170002524 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 509170002525 salt bridge; other site 509170002526 sequence-specific DNA binding site [nucleotide binding]; other site 509170002527 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 509170002528 Catalytic site [active] 509170002529 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 509170002530 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 509170002531 Prophage antirepressor [Transcription]; Region: COG3617 509170002532 BRO family, N-terminal domain; Region: Bro-N; smart01040 509170002533 hypothetical protein; Provisional; Region: PRK09741 509170002534 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 509170002535 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 509170002536 active site 509170002537 Terminase small subunit; Region: Terminase_2; cl01513 509170002538 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 509170002539 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 509170002540 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 509170002541 Phage capsid family; Region: Phage_capsid; pfam05065 509170002542 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein 509170002543 Phage-related protein [Function unknown]; Region: COG4695 509170002544 Phage portal protein; Region: Phage_portal; pfam04860 509170002545 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 509170002546 oligomerization interface [polypeptide binding]; other site 509170002547 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 509170002548 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 509170002549 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 509170002550 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 509170002551 ORF11CD3 domain; Region: ORF11CD3; pfam10549 509170002552 Lsr2; Region: Lsr2; pfam11774 509170002553 Arc-like DNA binding domain; Region: Arc; pfam03869 509170002554 AntA/AntB antirepressor; Region: AntA; pfam08346 509170002555 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 509170002556 Domain of unknown function (DUF1833); Region: DUF1833; pfam08875 509170002557 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 509170002558 catalytic site [active] 509170002559 Asp-box motif; other site 509170002560 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 509170002561 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 509170002562 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 509170002563 PAAR motif; Region: PAAR_motif; pfam05488 509170002564 integrase; Provisional; Region: PRK09692 509170002565 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 509170002566 active site 509170002567 Int/Topo IB signature motif; other site 509170002568 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170002569 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002570 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of isocitrate dehydrogenase (part 1) 509170002571 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of isocitrate dehydrogenase (part 2) 509170002572 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of isocitrate dehydrogenase (part 3) 509170002573 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein; membrane protein 509170002574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170002575 Major Facilitator Superfamily; Region: MFS_1; pfam07690 509170002576 putative substrate translocation pore; other site 509170002577 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509170002578 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509170002579 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 509170002580 putative dimerization interface [polypeptide binding]; other site 509170002581 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 509170002582 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 509170002583 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 509170002584 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 509170002585 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 509170002586 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 509170002587 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 509170002588 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 509170002589 Protein of unknown function (DUF3144); Region: DUF3144; pfam11342 509170002590 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170002591 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002592 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170002593 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170002594 Protein of unknown function (DUF962); Region: DUF962; pfam06127 509170002595 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 509170002596 thiamine phosphate binding site [chemical binding]; other site 509170002597 active site 509170002598 pyrophosphate binding site [ion binding]; other site 509170002599 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 509170002600 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 509170002601 inhibitor-cofactor binding pocket; inhibition site 509170002602 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170002603 catalytic residue [active] 509170002604 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of isochorismatase (part 1) 509170002605 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of isochorismatase (part 2) 509170002606 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 509170002607 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 509170002608 active site 509170002609 ATP-dependent helicase HepA; Validated; Region: PRK04914 509170002610 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 509170002611 ATP binding site [chemical binding]; other site 509170002612 putative Mg++ binding site [ion binding]; other site 509170002613 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 509170002614 nucleotide binding region [chemical binding]; other site 509170002615 ATP-binding site [chemical binding]; other site 509170002616 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170002617 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002618 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170002619 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170002620 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 509170002621 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509170002622 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 509170002623 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 509170002624 FAD binding pocket [chemical binding]; other site 509170002625 FAD binding motif [chemical binding]; other site 509170002626 phosphate binding motif [ion binding]; other site 509170002627 beta-alpha-beta structure motif; other site 509170002628 NAD binding pocket [chemical binding]; other site 509170002629 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 509170002630 catalytic loop [active] 509170002631 iron binding site [ion binding]; other site 509170002632 Fatty acid desaturase; Region: FA_desaturase; pfam00487 509170002633 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 509170002634 putative di-iron ligands [ion binding]; other site 509170002635 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 509170002636 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of HTH-type transcriptional regulator protein (LysR family) (part 1) 509170002637 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of HTH-type transcriptional regulator protein (LysR family) (part 2) 509170002638 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170002639 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002640 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of HTH-type transcriptional regulator protein (LysR family) (part 3) 509170002641 Protein of unknown function (DUF541); Region: SIMPL; cl01077 509170002642 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 509170002643 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 509170002644 inhibitor-cofactor binding pocket; inhibition site 509170002645 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170002646 catalytic residue [active] 509170002647 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 509170002648 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170002649 catalytic residue [active] 509170002650 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of aldehyde dehydrogenase (part 1) 509170002651 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170002652 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002653 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of aldehyde dehydrogenase (part 2) 509170002654 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 509170002655 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 509170002656 putative DNA binding site [nucleotide binding]; other site 509170002657 putative Zn2+ binding site [ion binding]; other site 509170002658 AsnC family; Region: AsnC_trans_reg; pfam01037 509170002659 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 509170002660 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 509170002661 dimer interface [polypeptide binding]; other site 509170002662 PYR/PP interface [polypeptide binding]; other site 509170002663 TPP binding site [chemical binding]; other site 509170002664 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 509170002665 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 509170002666 TPP-binding site [chemical binding]; other site 509170002667 dimer interface [polypeptide binding]; other site 509170002668 Evidence 7 : Gene remnant; PubMedId : 2408019; Product type t : transporter; fragment of aromatic amino acid transporter (AroP) (APC family) (part 1) 509170002669 Evidence 7 : Gene remnant; PubMedId : 2408019; Product type t : transporter; fragment of aromatic amino acid transporter (APC family) (AroP)(part 2) 509170002670 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 509170002671 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 509170002672 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 509170002673 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 509170002674 dimer interface [polypeptide binding]; other site 509170002675 conserved gate region; other site 509170002676 putative PBP binding loops; other site 509170002677 ABC-ATPase subunit interface; other site 509170002678 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 509170002679 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 509170002680 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 509170002681 dimer interface [polypeptide binding]; other site 509170002682 conserved gate region; other site 509170002683 putative PBP binding loops; other site 509170002684 ABC-ATPase subunit interface; other site 509170002685 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 509170002686 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 509170002687 Walker A/P-loop; other site 509170002688 ATP binding site [chemical binding]; other site 509170002689 Q-loop/lid; other site 509170002690 ABC transporter signature motif; other site 509170002691 Walker B; other site 509170002692 D-loop; other site 509170002693 H-loop/switch region; other site 509170002694 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 509170002695 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 509170002696 tandem repeat interface [polypeptide binding]; other site 509170002697 oligomer interface [polypeptide binding]; other site 509170002698 active site residues [active] 509170002699 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170002700 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002701 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170002702 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002703 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 509170002704 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 509170002705 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 509170002706 putative active site [active] 509170002707 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 509170002708 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 509170002709 Walker A/P-loop; other site 509170002710 ATP binding site [chemical binding]; other site 509170002711 Q-loop/lid; other site 509170002712 ABC transporter signature motif; other site 509170002713 Walker B; other site 509170002714 D-loop; other site 509170002715 H-loop/switch region; other site 509170002716 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 509170002717 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 509170002718 HlyD family secretion protein; Region: HlyD_3; pfam13437 509170002719 Uncharacterized conserved protein [Function unknown]; Region: COG1739 509170002720 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 509170002721 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 509170002722 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 509170002723 putative trimer interface [polypeptide binding]; other site 509170002724 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 509170002725 trimer interface [polypeptide binding]; other site 509170002726 active site 509170002727 substrate binding site [chemical binding]; other site 509170002728 putative CoA binding site [chemical binding]; other site 509170002729 CoA binding site [chemical binding]; other site 509170002730 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 509170002731 Ligand Binding Site [chemical binding]; other site 509170002732 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 509170002733 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 509170002734 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 509170002735 Ferredoxin [Energy production and conversion]; Region: COG1146 509170002736 4Fe-4S binding domain; Region: Fer4; cl02805 509170002737 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 509170002738 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 509170002739 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 509170002740 Coenzyme A binding pocket [chemical binding]; other site 509170002741 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 509170002742 MutS domain I; Region: MutS_I; pfam01624 509170002743 MutS domain II; Region: MutS_II; pfam05188 509170002744 MutS domain III; Region: MutS_III; pfam05192 509170002745 MutS domain V; Region: MutS_V; pfam00488 509170002746 Walker A/P-loop; other site 509170002747 ATP binding site [chemical binding]; other site 509170002748 Q-loop/lid; other site 509170002749 ABC transporter signature motif; other site 509170002750 Walker B; other site 509170002751 D-loop; other site 509170002752 H-loop/switch region; other site 509170002753 integrase; Provisional; Region: PRK09692 509170002754 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 509170002755 active site 509170002756 Int/Topo IB signature motif; other site 509170002757 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170002758 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002759 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 509170002760 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 509170002761 adenylosuccinate lyase; Provisional; Region: PRK09285 509170002762 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 509170002763 tetramer interface [polypeptide binding]; other site 509170002764 active site 509170002765 putative lysogenization regulator; Reviewed; Region: PRK00218 509170002766 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 509170002767 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 509170002768 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 509170002769 nudix motif; other site 509170002770 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 509170002771 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 509170002772 trimer interface [polypeptide binding]; other site 509170002773 putative metal binding site [ion binding]; other site 509170002774 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 509170002775 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 509170002776 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 509170002777 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 509170002778 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 509170002779 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 509170002780 Peptidase family M23; Region: Peptidase_M23; pfam01551 509170002781 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509170002782 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509170002783 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 509170002784 putative effector binding pocket; other site 509170002785 dimerization interface [polypeptide binding]; other site 509170002786 AAA domain; Region: AAA_32; pfam13654 509170002787 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 509170002788 primary dimer interface [polypeptide binding]; other site 509170002789 lon-related putative ATP-dependent protease; Region: lon_rel; TIGR00764 509170002790 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 509170002791 muropeptide transporter; Validated; Region: ampG; cl17669 509170002792 muropeptide transporter; Validated; Region: ampG; cl17669 509170002793 muropeptide transporter; Validated; Region: ampG; cl17669 509170002794 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 509170002795 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 509170002796 dimer interface [polypeptide binding]; other site 509170002797 active site 509170002798 metal binding site [ion binding]; metal-binding site 509170002799 glutathione binding site [chemical binding]; other site 509170002800 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 509170002801 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 509170002802 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 509170002803 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170002804 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002805 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170002806 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170002807 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170002808 Radical SAM superfamily; Region: Radical_SAM; pfam04055 509170002809 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 509170002810 FeS/SAM binding site; other site 509170002811 elongation factor P; Validated; Region: PRK00529 509170002812 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 509170002813 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 509170002814 RNA binding site [nucleotide binding]; other site 509170002815 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 509170002816 RNA binding site [nucleotide binding]; other site 509170002817 carbon starvation protein A; Provisional; Region: PRK15015 509170002818 Carbon starvation protein CstA; Region: CstA; pfam02554 509170002819 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 509170002820 Protein of unknown function (DUF466); Region: DUF466; pfam04328 509170002821 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170002822 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002823 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 509170002824 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 509170002825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 509170002826 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 509170002827 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 509170002828 substrate binding site [chemical binding]; other site 509170002829 active site 509170002830 Protein of unknown function (DUF817); Region: DUF817; pfam05675 509170002831 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 509170002832 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein; signal peptide (part 2) 509170002833 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein; signal peptide (part 3) 509170002834 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of Beta-lactamase precursor (Cephalosporinase) (partial) 509170002835 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170002836 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002837 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 509170002838 homodecamer interface [polypeptide binding]; other site 509170002839 GTP cyclohydrolase I; Provisional; Region: PLN03044 509170002840 active site 509170002841 putative catalytic site residues [active] 509170002842 zinc binding site [ion binding]; other site 509170002843 GTP-CH-I/GFRP interaction surface; other site 509170002844 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 509170002845 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 509170002846 catalytic loop [active] 509170002847 iron binding site [ion binding]; other site 509170002848 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 509170002849 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 509170002850 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 509170002851 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 509170002852 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 509170002853 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 509170002854 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 509170002855 XdhC Rossmann domain; Region: XdhC_C; pfam13478 509170002856 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 509170002857 Smr domain; Region: Smr; pfam01713 509170002858 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 509170002859 active site 509170002860 ribulose/triose binding site [chemical binding]; other site 509170002861 phosphate binding site [ion binding]; other site 509170002862 substrate (anthranilate) binding pocket [chemical binding]; other site 509170002863 product (indole) binding pocket [chemical binding]; other site 509170002864 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 509170002865 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 509170002866 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 509170002867 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of TonB-dependent receptor (part 1) 509170002868 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170002869 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002870 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of TonB-dependent receptor (part 2) 509170002871 Peptidase family M1; Region: Peptidase_M1; pfam01433 509170002872 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 509170002873 Zn binding site [ion binding]; other site 509170002874 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 509170002875 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 509170002876 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 509170002877 glutamine binding [chemical binding]; other site 509170002878 catalytic triad [active] 509170002879 Domain of unknown function (DUF4055); Region: DUF4055; pfam13264 509170002880 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 509170002881 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170002882 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002883 glutamine synthetase; Provisional; Region: glnA; PRK09469 509170002884 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 509170002885 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 509170002886 Chorismate lyase; Region: Chor_lyase; cl01230 509170002887 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 509170002888 UbiA prenyltransferase family; Region: UbiA; pfam01040 509170002889 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170002890 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170002891 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170002892 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 509170002893 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 509170002894 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 509170002895 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 509170002896 Uncharacterized conserved protein [Function unknown]; Region: COG0327 509170002897 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 509170002898 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 509170002899 protein binding site [polypeptide binding]; other site 509170002900 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 509170002901 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 509170002902 active site 509170002903 NTP binding site [chemical binding]; other site 509170002904 metal binding triad [ion binding]; metal-binding site 509170002905 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 509170002906 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 509170002907 Zn2+ binding site [ion binding]; other site 509170002908 Mg2+ binding site [ion binding]; other site 509170002909 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 509170002910 Malic enzyme, N-terminal domain; Region: malic; pfam00390 509170002911 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 509170002912 putative NAD(P) binding site [chemical binding]; other site 509170002913 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 509170002914 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509170002915 PAS fold; Region: PAS_3; pfam08447 509170002916 heme pocket [chemical binding]; other site 509170002917 putative active site [active] 509170002918 PAS domain S-box; Region: sensory_box; TIGR00229 509170002919 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509170002920 putative active site [active] 509170002921 heme pocket [chemical binding]; other site 509170002922 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 509170002923 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 509170002924 metal binding site [ion binding]; metal-binding site 509170002925 active site 509170002926 I-site; other site 509170002927 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 509170002928 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 509170002929 RNA methyltransferase, RsmE family; Region: TIGR00046 509170002930 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 509170002931 FAD binding site [chemical binding]; other site 509170002932 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 509170002933 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 509170002934 homotetramer interface [polypeptide binding]; other site 509170002935 ligand binding site [chemical binding]; other site 509170002936 catalytic site [active] 509170002937 NAD binding site [chemical binding]; other site 509170002938 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 509170002939 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 509170002940 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170002941 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002942 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 509170002943 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509170002944 active site 509170002945 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 509170002946 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170002947 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002948 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170002949 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002950 lipoyl synthase; Provisional; Region: PRK05481 509170002951 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 509170002952 FeS/SAM binding site; other site 509170002953 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 509170002954 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 509170002955 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 509170002956 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 509170002957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170002958 Major Facilitator Superfamily; Region: MFS_1; pfam07690 509170002959 putative substrate translocation pore; other site 509170002960 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of nitrate transporter transmembrane protein (MFS superfamily) (part 2) 509170002961 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of nitrate transporter transmembrane protein (MFS superfamily) (part 1) 509170002962 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 509170002963 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 509170002964 active site 509170002965 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 509170002966 rRNA interaction site [nucleotide binding]; other site 509170002967 S8 interaction site; other site 509170002968 putative laminin-1 binding site; other site 509170002969 elongation factor Ts; Provisional; Region: tsf; PRK09377 509170002970 UBA/TS-N domain; Region: UBA; pfam00627 509170002971 Elongation factor TS; Region: EF_TS; pfam00889 509170002972 Elongation factor TS; Region: EF_TS; pfam00889 509170002973 Protein of unknown function (DUF3465); Region: DUF3465; pfam11948 509170002974 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of transcriptional regulator (AraC/XylS family) (part 1) 509170002975 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of transcriptional regulator (AraC/XylS family) (part 2) 509170002976 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 509170002977 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170002978 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002979 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 509170002980 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 509170002981 Transglycosylase SLT domain; Region: SLT_2; pfam13406 509170002982 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 509170002983 N-acetyl-D-glucosamine binding site [chemical binding]; other site 509170002984 catalytic residue [active] 509170002985 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 509170002986 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 509170002987 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 509170002988 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 509170002989 inner membrane transport permease; Provisional; Region: PRK15066 509170002990 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 509170002991 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 509170002992 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 509170002993 Walker A/P-loop; other site 509170002994 ATP binding site [chemical binding]; other site 509170002995 Q-loop/lid; other site 509170002996 ABC transporter signature motif; other site 509170002997 Walker B; other site 509170002998 D-loop; other site 509170002999 H-loop/switch region; other site 509170003000 integrase; Provisional; Region: int; PHA02601 509170003001 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 509170003002 active site 509170003003 DNA binding site [nucleotide binding] 509170003004 Int/Topo IB signature motif; other site 509170003005 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003006 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003007 Evidence 7 : Gene remnant; PubMedId : 3313284; Product type t : transporter; fragment of histidine permease (ABC superfamily, atp_bind) (HisP) (part 1) 509170003008 Evidence 7 : Gene remnant; PubMedId : 7050725; Product type t : transporter; fragment of Histidine transport system permease protein (ABC superfamily, membrane) (HisM) (part 2) 509170003009 Evidence 7 : Gene remnant; PubMedId : 7050725; Product type t : transporter; fragment of Histidine transport system permease protein (ABC superfamily, membrane) (HisM) (part 1) 509170003010 Evidence 7 : Gene remnant; PubMedId : 7050725; Product type t : transporter; fragment of Histidine transport system permease protein (ABC superfamily, membrane) (HisQ) (part2) 509170003011 Evidence 7 : Gene remnant; PubMedId : 7050725; Product type t : transporter; fragment of Histidine transport system permease protein (ABC superfamily, membrane) (HisQ) (part 1) 509170003012 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170003013 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003014 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of bifunctional protein [Includes: transcriptional regulator; aminopeptidase] (part 2) 509170003015 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of bifunctional protein [Includes: transcriptional regulator; aminopeptidase] (part 1) 509170003016 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 509170003017 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 509170003018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 509170003019 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 509170003020 FAD binding pocket [chemical binding]; other site 509170003021 FAD binding motif [chemical binding]; other site 509170003022 phosphate binding motif [ion binding]; other site 509170003023 beta-alpha-beta structure motif; other site 509170003024 NAD binding pocket [chemical binding]; other site 509170003025 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 509170003026 homodimer interaction site [polypeptide binding]; other site 509170003027 cofactor binding site; other site 509170003028 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein; membrane protein (part 2) 509170003029 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein; membrane protein (part 1) 509170003030 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 509170003031 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 509170003032 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 509170003033 Walker A motif; other site 509170003034 ATP binding site [chemical binding]; other site 509170003035 Walker B motif; other site 509170003036 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 509170003037 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 509170003038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509170003039 active site 509170003040 phosphorylation site [posttranslational modification] 509170003041 intermolecular recognition site; other site 509170003042 dimerization interface [polypeptide binding]; other site 509170003043 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 509170003044 DNA binding site [nucleotide binding] 509170003045 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of two-component system sensor protein (part 1) 509170003046 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of two-component system sensor protein (part 2) 509170003047 hypothetical protein; Provisional; Region: PRK08999 509170003048 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 509170003049 active site 509170003050 8-oxo-dGMP binding site [chemical binding]; other site 509170003051 nudix motif; other site 509170003052 metal binding site [ion binding]; metal-binding site 509170003053 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 509170003054 active site 509170003055 pyrophosphate binding site [ion binding]; other site 509170003056 thiamine phosphate binding site [chemical binding]; other site 509170003057 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 509170003058 Transglycosylase; Region: Transgly; pfam00912 509170003059 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 509170003060 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231 509170003061 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 509170003062 Protein of unknown function (DUF1315); Region: DUF1315; pfam07023 509170003063 hypothetical protein; Validated; Region: PRK09071 509170003064 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 509170003065 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 509170003066 Evidence 7 : Gene remnant; Product type t : transporter; fragment of aerobic C4-dicarboxylate transport protein (part 1) 509170003067 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170003068 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003069 Evidence 7 : Gene remnant; Product type t : transporter; fragment of aerobic C4-dicarboxylate transport protein (part 2) 509170003070 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 509170003071 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509170003072 active site 509170003073 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 509170003074 Chorismate mutase type II; Region: CM_2; cl00693 509170003075 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 509170003076 Prephenate dehydratase; Region: PDT; pfam00800 509170003077 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 509170003078 putative L-Phe binding site [chemical binding]; other site 509170003079 bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK14806 509170003080 prephenate dehydrogenase; Validated; Region: PRK08507 509170003081 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 509170003082 hinge; other site 509170003083 active site 509170003084 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 509170003085 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 509170003086 metal binding site [ion binding]; metal-binding site 509170003087 dimer interface [polypeptide binding]; other site 509170003088 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 509170003089 Evidence 7 : Gene remnant; Product type r : regulator; fragment of Transcriptional regulatory protein RtcR (part 1) 509170003090 Evidence 7 : Gene remnant; Product type r : regulator; fragment of Transcriptional regulatory protein RtcR (part 2) 509170003091 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 509170003092 hypothetical protein; Validated; Region: PRK02101 509170003093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 509170003094 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 509170003095 ThiS interaction site; other site 509170003096 putative active site [active] 509170003097 tetramer interface [polypeptide binding]; other site 509170003098 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 509170003099 thiS-thiF/thiG interaction site; other site 509170003100 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 509170003101 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 509170003102 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 509170003103 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509170003104 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 509170003105 DNA binding residues [nucleotide binding] 509170003106 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 509170003107 CPxP motif; other site 509170003108 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170003109 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003110 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 509170003111 DNA-binding site [nucleotide binding]; DNA binding site 509170003112 RNA-binding motif; other site 509170003113 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 509170003114 DEAD-like helicases superfamily; Region: DEXDc; smart00487 509170003115 ATP binding site [chemical binding]; other site 509170003116 Mg++ binding site [ion binding]; other site 509170003117 motif III; other site 509170003118 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 509170003119 nucleotide binding region [chemical binding]; other site 509170003120 ATP-binding site [chemical binding]; other site 509170003121 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 509170003122 putative FMN binding site [chemical binding]; other site 509170003123 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 509170003124 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 509170003125 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 509170003126 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 509170003127 catalytic core [active] 509170003128 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 509170003129 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 509170003130 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 509170003131 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 509170003132 quinone interaction residues [chemical binding]; other site 509170003133 active site 509170003134 catalytic residues [active] 509170003135 FMN binding site [chemical binding]; other site 509170003136 substrate binding site [chemical binding]; other site 509170003137 Colicin V production protein; Region: Colicin_V; pfam02674 509170003138 amidophosphoribosyltransferase; Provisional; Region: PRK09246 509170003139 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 509170003140 active site 509170003141 tetramer interface [polypeptide binding]; other site 509170003142 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 509170003143 active site 509170003144 Peptidase family M48; Region: Peptidase_M48; cl12018 509170003145 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 509170003146 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 509170003147 dimerization interface [polypeptide binding]; other site 509170003148 ligand binding site [chemical binding]; other site 509170003149 NADP binding site [chemical binding]; other site 509170003150 catalytic site [active] 509170003151 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 509170003152 Peptidase family M48; Region: Peptidase_M48; cl12018 509170003153 Yqey-like protein; Region: YqeY; pfam09424 509170003154 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 509170003155 UGMP family protein; Validated; Region: PRK09604 509170003156 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 509170003157 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 509170003158 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170003159 Walker A motif; other site 509170003160 ATP binding site [chemical binding]; other site 509170003161 Walker B motif; other site 509170003162 Domain of unknown function (DUF3336); Region: DUF3336; pfam11815 509170003163 Triacylglycerol lipase 3, 4, and 5 and Sugar-Dependent 1 lipase; Region: Pat_TGL3-4-5_SDP1; cd07206 509170003164 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 509170003165 active site 509170003166 nucleophile elbow; other site 509170003167 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 509170003168 substrate binding site [chemical binding]; other site 509170003169 activation loop (A-loop); other site 509170003170 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 509170003171 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170003172 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003173 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of hemolysin activator protein (part 1) 509170003174 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170003175 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003176 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of hemolysin activator protein (part 2) 509170003177 Evidence 7 : Gene remnant; Product type ps : structure; fragment of hemagglutinin/hemolysin-related protein (part 1) 509170003178 Evidence 7 : Gene remnant; Product type ps : structure; fragment of hemagglutinin/hemolysin-related protein (part 2) 509170003179 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170003180 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003181 Evidence 7 : Gene remnant; Product type ps : structure; fragment of hemagglutinin/hemolysin-related protein (part 3) 509170003182 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170003183 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003184 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003185 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170003186 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003187 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of HTH-type transcriptional regulator (AraC family) (partial) 509170003188 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 509170003189 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 509170003190 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 509170003191 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170003192 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003193 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003194 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170003195 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003196 proline/glycine betaine transporter; Provisional; Region: PRK10642 509170003197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170003198 putative substrate translocation pore; other site 509170003199 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 509170003200 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 509170003201 Zn2+ binding site [ion binding]; other site 509170003202 Mg2+ binding site [ion binding]; other site 509170003203 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003204 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003205 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 509170003206 EamA-like transporter family; Region: EamA; pfam00892 509170003207 EamA-like transporter family; Region: EamA; pfam00892 509170003208 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of aminotransferase (part 2) 509170003209 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170003210 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003211 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of aminotransferase (part 1) 509170003212 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003213 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003214 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170003215 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 509170003216 non-specific DNA binding site [nucleotide binding]; other site 509170003217 salt bridge; other site 509170003218 Predicted transcriptional regulator [Transcription]; Region: COG2932 509170003219 sequence-specific DNA binding site [nucleotide binding]; other site 509170003220 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 509170003221 Catalytic site [active] 509170003222 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 509170003223 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 509170003224 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 509170003225 cofactor binding site; other site 509170003226 DNA binding site [nucleotide binding] 509170003227 substrate interaction site [chemical binding]; other site 509170003228 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 509170003229 Protein of unknown function (DUF1376); Region: DUF1376; pfam07120 509170003230 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 509170003231 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 509170003232 putative active site [active] 509170003233 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003234 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003235 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170003236 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003237 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of integrase from bacteriophage (partial) 509170003238 Cell division protein ZapA; Region: ZapA; pfam05164 509170003239 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 509170003240 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 509170003241 proline aminopeptidase P II; Provisional; Region: PRK10879 509170003242 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 509170003243 active site 509170003244 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 509170003245 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 509170003246 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 509170003247 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 509170003248 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 509170003249 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 509170003250 DNA binding residues [nucleotide binding] 509170003251 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 509170003252 Lysine efflux permease [General function prediction only]; Region: COG1279 509170003253 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 509170003254 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509170003255 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509170003256 dimerization interface [polypeptide binding]; other site 509170003257 Predicted methyltransferases [General function prediction only]; Region: COG0313 509170003258 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 509170003259 putative SAM binding site [chemical binding]; other site 509170003260 putative homodimer interface [polypeptide binding]; other site 509170003261 hypothetical protein; Provisional; Region: PRK14674 509170003262 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 509170003263 BON domain; Region: BON; pfam04972 509170003264 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 509170003265 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 509170003266 substrate binding pocket [chemical binding]; other site 509170003267 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 509170003268 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 509170003269 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 509170003270 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 509170003271 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 509170003272 putative NADH binding site [chemical binding]; other site 509170003273 putative active site [active] 509170003274 nudix motif; other site 509170003275 putative metal binding site [ion binding]; other site 509170003276 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170003277 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170003278 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003279 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170003280 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 509170003281 RNA/DNA hybrid binding site [nucleotide binding]; other site 509170003282 active site 509170003283 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 509170003284 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 509170003285 active site 509170003286 catalytic site [active] 509170003287 substrate binding site [chemical binding]; other site 509170003288 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 509170003289 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 509170003290 N-acetyl-D-glucosamine binding site [chemical binding]; other site 509170003291 catalytic residue [active] 509170003292 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 509170003293 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 509170003294 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 509170003295 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 509170003296 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 509170003297 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 509170003298 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 509170003299 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 509170003300 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 509170003301 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 509170003302 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 509170003303 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of oligopeptide transport protein (ABC superfamily, peri_bind) (partial) 509170003304 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003305 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003306 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of oligopeptide transport protein (ABC superfamily, atp_bind) (part 1) 509170003307 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of oligopeptide transport protein (ABC superfamily, atp_bind) (part 2) 509170003308 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 509170003309 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 509170003310 putative active site [active] 509170003311 putative FMN binding site [chemical binding]; other site 509170003312 putative substrate binding site [chemical binding]; other site 509170003313 putative catalytic residue [active] 509170003314 Evidence 7 : Gene remnant; Product type prc : receptor; fragment of TonB-dependent siderophore receptor precursor (part 2) 509170003315 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170003316 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170003317 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of TonB-dependent siderophore receptor precursor (part 1) 509170003318 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 509170003319 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 509170003320 dimer interface [polypeptide binding]; other site 509170003321 catalytic site [active] 509170003322 putative active site [active] 509170003323 putative substrate binding site [chemical binding]; other site 509170003324 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 509170003325 active site 509170003326 substrate binding pocket [chemical binding]; other site 509170003327 dimer interface [polypeptide binding]; other site 509170003328 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 509170003329 metal binding site [ion binding]; metal-binding site 509170003330 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170003331 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170003332 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003333 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170003334 argininosuccinate synthase; Provisional; Region: PRK13820 509170003335 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 509170003336 ANP binding site [chemical binding]; other site 509170003337 Substrate Binding Site II [chemical binding]; other site 509170003338 Substrate Binding Site I [chemical binding]; other site 509170003339 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003340 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003341 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 509170003342 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 509170003343 active site 509170003344 FMN binding site [chemical binding]; other site 509170003345 2,4-decadienoyl-CoA binding site; other site 509170003346 catalytic residue [active] 509170003347 4Fe-4S cluster binding site [ion binding]; other site 509170003348 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 509170003349 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 509170003350 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 509170003351 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 509170003352 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 509170003353 active site 509170003354 DNA binding site [nucleotide binding] 509170003355 Int/Topo IB signature motif; other site 509170003356 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003357 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003358 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 509170003359 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 509170003360 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 509170003361 RTX toxin acyltransferase family; Region: HlyC; cl01131 509170003362 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170003363 HTH-like domain; Region: HTH_21; pfam13276 509170003364 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003365 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003366 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 509170003367 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 509170003368 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 509170003369 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 509170003370 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 509170003371 RHS Repeat; Region: RHS_repeat; pfam05593 509170003372 RHS Repeat; Region: RHS_repeat; pfam05593 509170003373 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 509170003374 RHS Repeat; Region: RHS_repeat; pfam05593 509170003375 RHS protein; Region: RHS; pfam03527 509170003376 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 509170003377 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003378 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003379 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170003380 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170003381 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003382 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170003383 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003384 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003385 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 509170003386 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003387 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003388 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of transcriptional regulator (AraC family) 509170003389 EamA-like transporter family; Region: EamA; pfam00892 509170003390 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 509170003391 EamA-like transporter family; Region: EamA; cl17759 509170003392 galactarate dehydratase; Region: galactar-dH20; TIGR03248 509170003393 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 509170003394 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 509170003395 Evidence 7 : Gene remnant; Product type t : transporter; fragment of D-glucarate/D-galactarate permease (MFS superfamily) (part 2) 509170003396 Evidence 7 : Gene remnant; Product type t : transporter; fragment of D-glucarate/D-galactarate permease (MFS superfamily) (part 1) 509170003397 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 509170003398 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 509170003399 active site 509170003400 tetramer interface [polypeptide binding]; other site 509170003401 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 509170003402 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 509170003403 putative active site [active] 509170003404 catalytic residue [active] 509170003405 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 509170003406 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 509170003407 dimer interface [polypeptide binding]; other site 509170003408 NADP binding site [chemical binding]; other site 509170003409 catalytic residues [active] 509170003410 Transcriptional regulators [Transcription]; Region: FadR; COG2186 509170003411 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509170003412 DNA-binding site [nucleotide binding]; DNA binding site 509170003413 FCD domain; Region: FCD; pfam07729 509170003414 Tannase and feruloyl esterase; Region: Tannase; pfam07519 509170003415 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 509170003416 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170003417 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170003418 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170003419 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 509170003420 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 509170003421 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509170003422 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 509170003423 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 509170003424 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 509170003425 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 509170003426 classical (c) SDRs; Region: SDR_c; cd05233 509170003427 short chain dehydrogenase; Provisional; Region: PRK05650 509170003428 NAD(P) binding site [chemical binding]; other site 509170003429 active site 509170003430 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 509170003431 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 509170003432 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509170003433 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509170003434 Pirin-related protein [General function prediction only]; Region: COG1741 509170003435 Pirin; Region: Pirin; pfam02678 509170003436 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 509170003437 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 509170003438 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 509170003439 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of short-chain dehydrogenase (partial) 509170003440 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003441 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003442 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 509170003443 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 509170003444 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 509170003445 active site 509170003446 purine riboside binding site [chemical binding]; other site 509170003447 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 509170003448 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 509170003449 RNA/DNA hybrid binding site [nucleotide binding]; other site 509170003450 active site 509170003451 carbon storage regulator; Provisional; Region: PRK01712 509170003452 aspartate kinase; Reviewed; Region: PRK06635 509170003453 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 509170003454 putative nucleotide binding site [chemical binding]; other site 509170003455 putative catalytic residues [active] 509170003456 putative Mg ion binding site [ion binding]; other site 509170003457 putative aspartate binding site [chemical binding]; other site 509170003458 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 509170003459 putative allosteric regulatory site; other site 509170003460 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 509170003461 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 509170003462 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 509170003463 motif 1; other site 509170003464 active site 509170003465 motif 2; other site 509170003466 motif 3; other site 509170003467 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 509170003468 DHHA1 domain; Region: DHHA1; pfam02272 509170003469 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 509170003470 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 509170003471 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 509170003472 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170003473 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003474 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 509170003475 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 509170003476 dimer interface [polypeptide binding]; other site 509170003477 motif 1; other site 509170003478 active site 509170003479 motif 2; other site 509170003480 motif 3; other site 509170003481 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 509170003482 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 509170003483 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 509170003484 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003485 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003486 Peptidase family M48; Region: Peptidase_M48; pfam01435 509170003487 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 509170003488 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 509170003489 active site 509170003490 catalytic tetrad [active] 509170003491 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170003492 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003493 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of bifunctional protein [Includes: transcriptional regulator; aminopeptidase] (part 1) 509170003494 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of bifunctional protein [Includes: transcriptional regulator; aminopeptidase] (part 2) 509170003495 putative protease; Provisional; Region: PRK15452 509170003496 Peptidase family U32; Region: Peptidase_U32; pfam01136 509170003497 archaeoflavoprotein, MJ0208 family; Region: flavo_MJ0208; TIGR02700 509170003498 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003499 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003500 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 509170003501 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 509170003502 PAAR motif; Region: PAAR_motif; pfam05488 509170003503 PAAR motif; Region: PAAR_motif; pfam05488 509170003504 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003505 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003506 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 509170003507 exodeoxyribonuclease X; Provisional; Region: PRK07983 509170003508 active site 509170003509 catalytic site [active] 509170003510 substrate binding site [chemical binding]; other site 509170003511 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 509170003512 Secretory lipase; Region: LIP; pfam03583 509170003513 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 509170003514 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 509170003515 dimer interface [polypeptide binding]; other site 509170003516 active site 509170003517 glycine-pyridoxal phosphate binding site [chemical binding]; other site 509170003518 folate binding site [chemical binding]; other site 509170003519 Evidence 7 : Gene remnant; Product type pm : membrane component; fragment of Outer membrane efflux protein (part 2) 509170003520 Evidence 7 : Gene remnant; Product type pm : membrane component; fragment of Outer membrane efflux protein (part 1) 509170003521 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 509170003522 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 509170003523 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 509170003524 HlyD family secretion protein; Region: HlyD_3; pfam13437 509170003525 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509170003526 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509170003527 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 509170003528 putative effector binding pocket; other site 509170003529 putative dimerization interface [polypeptide binding]; other site 509170003530 Evidence 7 : Gene remnant; Product type t : transporter; fragment of Lysine-arginine-ornithine-histidine-binding periplasmic protein precursor (ABC superfamily, peri_bind) (partial) 509170003531 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170003532 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003533 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170003534 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 509170003535 Coenzyme A binding pocket [chemical binding]; other site 509170003536 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 509170003537 Peptidase family M23; Region: Peptidase_M23; pfam01551 509170003538 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 509170003539 Clp amino terminal domain; Region: Clp_N; pfam02861 509170003540 Clp amino terminal domain; Region: Clp_N; pfam02861 509170003541 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170003542 Walker A motif; other site 509170003543 ATP binding site [chemical binding]; other site 509170003544 Walker B motif; other site 509170003545 arginine finger; other site 509170003546 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170003547 Walker A motif; other site 509170003548 ATP binding site [chemical binding]; other site 509170003549 Walker B motif; other site 509170003550 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 509170003551 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170003552 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003553 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170003554 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 509170003555 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 509170003556 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 509170003557 DNA methylase; Region: N6_N4_Mtase; cl17433 509170003558 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 509170003559 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 509170003560 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 509170003561 dihydroorotase; Validated; Region: pyrC; PRK09357 509170003562 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 509170003563 active site 509170003564 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 509170003565 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 509170003566 ligand binding site [chemical binding]; other site 509170003567 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 509170003568 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 509170003569 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 509170003570 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 509170003571 putative C-terminal domain interface [polypeptide binding]; other site 509170003572 putative GSH binding site (G-site) [chemical binding]; other site 509170003573 putative dimer interface [polypeptide binding]; other site 509170003574 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 509170003575 putative N-terminal domain interface [polypeptide binding]; other site 509170003576 putative dimer interface [polypeptide binding]; other site 509170003577 putative substrate binding pocket (H-site) [chemical binding]; other site 509170003578 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 509170003579 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 509170003580 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 509170003581 generic binding surface II; other site 509170003582 generic binding surface I; other site 509170003583 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 509170003584 putative active site [active] 509170003585 putative catalytic site [active] 509170003586 putative Mg binding site IVb [ion binding]; other site 509170003587 putative phosphate binding site [ion binding]; other site 509170003588 putative DNA binding site [nucleotide binding]; other site 509170003589 putative Mg binding site IVa [ion binding]; other site 509170003590 glutathionine S-transferase; Provisional; Region: PRK10542 509170003591 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 509170003592 C-terminal domain interface [polypeptide binding]; other site 509170003593 GSH binding site (G-site) [chemical binding]; other site 509170003594 dimer interface [polypeptide binding]; other site 509170003595 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 509170003596 dimer interface [polypeptide binding]; other site 509170003597 N-terminal domain interface [polypeptide binding]; other site 509170003598 substrate binding pocket (H-site) [chemical binding]; other site 509170003599 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 509170003600 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 509170003601 catalytic residue [active] 509170003602 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 509170003603 catalytic residues [active] 509170003604 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 509170003605 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 509170003606 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003607 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003608 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 509170003609 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 509170003610 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509170003611 S-adenosylmethionine binding site [chemical binding]; other site 509170003612 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170003613 peroxiredoxin; Region: AhpC; TIGR03137 509170003614 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 509170003615 dimer interface [polypeptide binding]; other site 509170003616 decamer (pentamer of dimers) interface [polypeptide binding]; other site 509170003617 catalytic triad [active] 509170003618 peroxidatic and resolving cysteines [active] 509170003619 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 509170003620 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 509170003621 ATP binding site [chemical binding]; other site 509170003622 putative Mg++ binding site [ion binding]; other site 509170003623 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 509170003624 nucleotide binding region [chemical binding]; other site 509170003625 ATP-binding site [chemical binding]; other site 509170003626 Helicase associated domain (HA2); Region: HA2; pfam04408 509170003627 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 509170003628 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 509170003629 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 509170003630 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 509170003631 dimer interface [polypeptide binding]; other site 509170003632 active site 509170003633 CoA binding pocket [chemical binding]; other site 509170003634 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003635 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003636 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of Benzoate 1,2 dioxygenase beta subunit (benB) 509170003637 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 509170003638 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 509170003639 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 509170003640 putative alpha subunit interface [polypeptide binding]; other site 509170003641 putative active site [active] 509170003642 putative substrate binding site [chemical binding]; other site 509170003643 Fe binding site [ion binding]; other site 509170003644 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 509170003645 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509170003646 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 509170003647 dimerizarion interface [polypeptide binding]; other site 509170003648 CrgA pocket; other site 509170003649 substrate binding pocket [chemical binding]; other site 509170003650 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 509170003651 metal-binding site [ion binding] 509170003652 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 509170003653 metal-binding site [ion binding] 509170003654 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 509170003655 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 509170003656 metal-binding site [ion binding] 509170003657 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 509170003658 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 509170003659 motif II; other site 509170003660 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 509170003661 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 509170003662 DNA binding residues [nucleotide binding] 509170003663 dimer interface [polypeptide binding]; other site 509170003664 copper binding site [ion binding]; other site 509170003665 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 509170003666 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 509170003667 dimerization interface [polypeptide binding]; other site 509170003668 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170003669 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003670 Evidence 7 : Gene remnant; Product type t : transporter; fragment of C4-dicarboxylate transport protein (partial) 509170003671 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003672 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003673 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 509170003674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 509170003675 dimer interface [polypeptide binding]; other site 509170003676 conserved gate region; other site 509170003677 ABC-ATPase subunit interface; other site 509170003678 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 509170003679 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 509170003680 Walker A/P-loop; other site 509170003681 ATP binding site [chemical binding]; other site 509170003682 Q-loop/lid; other site 509170003683 ABC transporter signature motif; other site 509170003684 Walker B; other site 509170003685 D-loop; other site 509170003686 H-loop/switch region; other site 509170003687 NIL domain; Region: NIL; pfam09383 509170003688 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 509170003689 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 509170003690 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 509170003691 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 509170003692 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 509170003693 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 509170003694 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 509170003695 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 509170003696 purine monophosphate binding site [chemical binding]; other site 509170003697 dimer interface [polypeptide binding]; other site 509170003698 putative catalytic residues [active] 509170003699 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 509170003700 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 509170003701 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 509170003702 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 509170003703 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 509170003704 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 509170003705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509170003706 S-adenosylmethionine binding site [chemical binding]; other site 509170003707 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170003708 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 509170003709 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 509170003710 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 509170003711 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170003712 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003713 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of nitrite reductase, large subunit, nucleotide-and Fe/S-cluster binding (partial) 509170003714 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 509170003715 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 509170003716 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 509170003717 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 509170003718 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 509170003719 [4Fe-4S] binding site [ion binding]; other site 509170003720 molybdopterin cofactor binding site; other site 509170003721 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 509170003722 molybdopterin cofactor binding site; other site 509170003723 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 509170003724 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 509170003725 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 509170003726 GTP binding site; other site 509170003727 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003728 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003729 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 509170003730 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 509170003731 dimer interface [polypeptide binding]; other site 509170003732 active site 509170003733 Schiff base residues; other site 509170003734 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 509170003735 Serine hydrolase (FSH1); Region: FSH1; pfam03959 509170003736 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of Beta-ketoadipyl CoA thiolase (part 1) 509170003737 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of Beta-ketoadipyl CoA thiolase (part 2) 509170003738 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 509170003739 EamA-like transporter family; Region: EamA; pfam00892 509170003740 EamA-like transporter family; Region: EamA; pfam00892 509170003741 Helix-turn-helix domain; Region: HTH_18; pfam12833 509170003742 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509170003743 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170003744 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170003745 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of glutathione S-transferase (partial) 509170003746 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of short chain dehydrogenase (partial) 509170003747 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170003748 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003749 chorismate mutase; Provisional; Region: PRK08055 509170003750 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 509170003751 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 509170003752 putative DNA binding site [nucleotide binding]; other site 509170003753 putative Zn2+ binding site [ion binding]; other site 509170003754 AsnC family; Region: AsnC_trans_reg; pfam01037 509170003755 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003756 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003757 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509170003758 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509170003759 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 509170003760 putative dimerization interface [polypeptide binding]; other site 509170003761 LrgA family; Region: LrgA; cl00608 509170003762 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 509170003763 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 509170003764 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509170003765 DNA-binding site [nucleotide binding]; DNA binding site 509170003766 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 509170003767 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170003768 homodimer interface [polypeptide binding]; other site 509170003769 catalytic residue [active] 509170003770 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of transcriptional regulator (part 1) 509170003771 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of transcriptional regulator (part 2) 509170003772 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 509170003773 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 509170003774 Major Facilitator Superfamily; Region: MFS_1; pfam07690 509170003775 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170003776 putative substrate translocation pore; other site 509170003777 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003778 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003779 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of alkyl hydroperoxide reductase subunit, FAD/NAD(P)-binding, detoxification of hydroperoxides (partial) 509170003780 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 509170003781 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 509170003782 TPR motif; other site 509170003783 binding surface 509170003784 serine O-acetyltransferase; Region: cysE; TIGR01172 509170003785 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 509170003786 trimer interface [polypeptide binding]; other site 509170003787 active site 509170003788 substrate binding site [chemical binding]; other site 509170003789 CoA binding site [chemical binding]; other site 509170003790 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 509170003791 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 509170003792 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 509170003793 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 509170003794 putative active site [active] 509170003795 putative PHP Thumb interface [polypeptide binding]; other site 509170003796 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 509170003797 generic binding surface I; other site 509170003798 generic binding surface II; other site 509170003799 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170003800 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170003801 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170003802 Predicted transcriptional regulator [Transcription]; Region: COG2378 509170003803 WYL domain; Region: WYL; pfam13280 509170003804 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170003805 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003806 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003807 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of alanine racemase 1, biosynthetic (partial) 509170003808 replicative DNA helicase; Region: DnaB; TIGR00665 509170003809 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 509170003810 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 509170003811 Walker A motif; other site 509170003812 ATP binding site [chemical binding]; other site 509170003813 Walker B motif; other site 509170003814 DNA binding loops [nucleotide binding] 509170003815 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 509170003816 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 509170003817 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 509170003818 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 509170003819 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 509170003820 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 509170003821 UbiA prenyltransferase family; Region: UbiA; pfam01040 509170003822 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 509170003823 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 509170003824 Subunit I/III interface [polypeptide binding]; other site 509170003825 Subunit III/IV interface [polypeptide binding]; other site 509170003826 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 509170003827 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 509170003828 D-pathway; other site 509170003829 Putative ubiquinol binding site [chemical binding]; other site 509170003830 Low-spin heme (heme b) binding site [chemical binding]; other site 509170003831 Putative water exit pathway; other site 509170003832 Binuclear center (heme o3/CuB) [ion binding]; other site 509170003833 K-pathway; other site 509170003834 Putative proton exit pathway; other site 509170003835 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 509170003836 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 509170003837 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 509170003838 RDD family; Region: RDD; pfam06271 509170003839 phosphoenolpyruvate synthase; Validated; Region: PRK06464 509170003840 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 509170003841 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 509170003842 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 509170003843 PEP synthetase regulatory protein; Provisional; Region: PRK05339 509170003844 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170003845 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170003846 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of transcriptional regulator (LysR family) (part 2) 509170003847 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of transcriptional regulator (LysR family)(part 1) 509170003848 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 509170003849 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 509170003850 potential catalytic triad [active] 509170003851 conserved cys residue [active] 509170003852 peptide chain release factor 1; Validated; Region: prfA; PRK00591 509170003853 This domain is found in peptide chain release factors; Region: PCRF; smart00937 509170003854 RF-1 domain; Region: RF-1; pfam00472 509170003855 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 509170003856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509170003857 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 509170003858 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 509170003859 SurA N-terminal domain; Region: SurA_N; pfam09312 509170003860 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509170003861 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 509170003862 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 509170003863 NAD binding site [chemical binding]; other site 509170003864 homodimer interface [polypeptide binding]; other site 509170003865 homotetramer interface [polypeptide binding]; other site 509170003866 active site 509170003867 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 509170003868 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509170003869 active site 509170003870 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 509170003871 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 509170003872 acyl-activating enzyme (AAE) consensus motif; other site 509170003873 AMP binding site [chemical binding]; other site 509170003874 active site 509170003875 CoA binding site [chemical binding]; other site 509170003876 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 509170003877 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 509170003878 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 509170003879 ATP binding site [chemical binding]; other site 509170003880 substrate interface [chemical binding]; other site 509170003881 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 509170003882 ABC1 family; Region: ABC1; cl17513 509170003883 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 509170003884 substrate binding site [chemical binding]; other site 509170003885 activation loop (A-loop); other site 509170003886 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 509170003887 homooctamer interface [polypeptide binding]; other site 509170003888 active site 509170003889 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 509170003890 catalytic center binding site [active] 509170003891 ATP binding site [chemical binding]; other site 509170003892 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 509170003893 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 509170003894 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 509170003895 Soluble P-type ATPase [General function prediction only]; Region: COG4087 509170003896 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 509170003897 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 509170003898 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 509170003899 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 509170003900 Ligand Binding Site [chemical binding]; other site 509170003901 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509170003902 dimer interface [polypeptide binding]; other site 509170003903 phosphorylation site [posttranslational modification] 509170003904 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509170003905 ATP binding site [chemical binding]; other site 509170003906 Mg2+ binding site [ion binding]; other site 509170003907 G-X-G motif; other site 509170003908 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 509170003909 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509170003910 active site 509170003911 phosphorylation site [posttranslational modification] 509170003912 intermolecular recognition site; other site 509170003913 dimerization interface [polypeptide binding]; other site 509170003914 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 509170003915 DNA binding site [nucleotide binding] 509170003916 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 509170003917 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 509170003918 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003919 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003920 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 509170003921 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 509170003922 diiron binding motif [ion binding]; other site 509170003923 lysophospholipid transporter LplT; Provisional; Region: PRK11195 509170003924 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170003925 putative substrate translocation pore; other site 509170003926 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 509170003927 Surface antigen; Region: Bac_surface_Ag; pfam01103 509170003928 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 509170003929 Family of unknown function (DUF490); Region: DUF490; pfam04357 509170003930 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 509170003931 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 509170003932 substrate binding site [chemical binding]; other site 509170003933 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 509170003934 substrate binding site [chemical binding]; other site 509170003935 ligand binding site [chemical binding]; other site 509170003936 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170003937 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003938 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170003939 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170003940 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170003941 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509170003942 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509170003943 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 509170003944 putative dimerization interface [polypeptide binding]; other site 509170003945 Protein of unknown function (DUF441); Region: DUF441; pfam04284 509170003946 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 509170003947 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 509170003948 RNA binding surface [nucleotide binding]; other site 509170003949 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 509170003950 active site 509170003951 uracil binding [chemical binding]; other site 509170003952 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 509170003953 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 509170003954 Coenzyme A binding pocket [chemical binding]; other site 509170003955 RelB antitoxin; Region: RelB; cl01171 509170003956 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 509170003957 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 509170003958 probable active site [active] 509170003959 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 509170003960 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 509170003961 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509170003962 ATP binding site [chemical binding]; other site 509170003963 Mg2+ binding site [ion binding]; other site 509170003964 G-X-G motif; other site 509170003965 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 509170003966 ATP binding site [chemical binding]; other site 509170003967 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 509170003968 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 509170003969 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 509170003970 bacterial Hfq-like; Region: Hfq; cd01716 509170003971 hexamer interface [polypeptide binding]; other site 509170003972 Sm1 motif; other site 509170003973 RNA binding site [nucleotide binding]; other site 509170003974 Sm2 motif; other site 509170003975 Evidence 7 : Gene remnant; Product type pm : membrane component; fragment of integral membrane protein (partial) 509170003976 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170003977 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170003978 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 509170003979 putative active site [active] 509170003980 putative metal binding site [ion binding]; other site 509170003981 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 509170003982 substrate binding site [chemical binding]; other site 509170003983 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 509170003984 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 509170003985 active site 509170003986 HIGH motif; other site 509170003987 nucleotide binding site [chemical binding]; other site 509170003988 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 509170003989 KMSKS motif; other site 509170003990 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 509170003991 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003992 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003993 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 509170003994 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 509170003995 catalytic triad [active] 509170003996 Evidence 7 : Gene remnant; PubMedId : 2197274; Product type e : enzyme; fragment of ethanolamine ammonia-lyase light chain (Ethanolamine ammonia-lyase small subunit) (EutC) (part 2) 509170003997 Evidence 7 : Gene remnant; PubMedId : 2197274; Product type e : enzyme; fragment of ethanolamine ammonia-lyase light chain (Ethanolamine ammonia-lyase small subunit) (EutC) (part 1) 509170003998 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 509170003999 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 509170004000 ethanolamine permease; Region: 2A0305; TIGR00908 509170004001 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 509170004002 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 509170004003 NAD(P) binding site [chemical binding]; other site 509170004004 catalytic residues [active] 509170004005 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 509170004006 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 509170004007 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 509170004008 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 509170004009 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 509170004010 dimer interface [polypeptide binding]; other site 509170004011 active site 509170004012 metal binding site [ion binding]; metal-binding site 509170004013 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170004014 PIF1-like helicase; Region: PIF1; pfam05970 509170004015 Walker A motif; other site 509170004016 ATP binding site [chemical binding]; other site 509170004017 Walker B motif; other site 509170004018 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 509170004019 putative substrate binding pocket [chemical binding]; other site 509170004020 trimer interface [polypeptide binding]; other site 509170004021 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 509170004022 substrate binding site [chemical binding]; other site 509170004023 multimerization interface [polypeptide binding]; other site 509170004024 ATP binding site [chemical binding]; other site 509170004025 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170004026 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004027 aminopeptidase N; Provisional; Region: pepN; PRK14015 509170004028 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 509170004029 active site 509170004030 Zn binding site [ion binding]; other site 509170004031 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170004032 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170004033 synaptic vesicle protein SV2; Region: synapt_SV2; TIGR01299 509170004034 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 509170004035 Mechanosensitive ion channel; Region: MS_channel; pfam00924 509170004036 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170004037 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170004038 bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604 509170004039 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 509170004040 trimer interface [polypeptide binding]; other site 509170004041 putative active site [active] 509170004042 dimer interface [polypeptide binding]; other site 509170004043 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 509170004044 MPT binding site; other site 509170004045 trimer interface [polypeptide binding]; other site 509170004046 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 509170004047 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 509170004048 dimer interface [polypeptide binding]; other site 509170004049 putative functional site; other site 509170004050 putative MPT binding site; other site 509170004051 Predicted transcriptional regulators [Transcription]; Region: COG1733 509170004052 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 509170004053 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509170004054 DNA-binding site [nucleotide binding]; DNA binding site 509170004055 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 509170004056 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 509170004057 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170004058 homodimer interface [polypeptide binding]; other site 509170004059 catalytic residue [active] 509170004060 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 509170004061 EamA-like transporter family; Region: EamA; pfam00892 509170004062 EamA-like transporter family; Region: EamA; pfam00892 509170004063 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 509170004064 DsrC like protein; Region: DsrC; pfam04358 509170004065 sulfur relay protein TusD/DsrE; Region: sulf_tusD_dsrE; TIGR03012 509170004066 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of UDP-galactose 4-epimerase (GalE-like) (partial) 509170004067 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004068 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004069 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170004070 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170004071 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 509170004072 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 509170004073 hydroxyglutarate oxidase; Provisional; Region: PRK11728 509170004074 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 509170004075 homotrimer interaction site [polypeptide binding]; other site 509170004076 zinc binding site [ion binding]; other site 509170004077 CDP-binding sites; other site 509170004078 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 509170004079 active site 509170004080 catalytic residues [active] 509170004081 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004082 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004083 ornithine carbamoyltransferase; Provisional; Region: PRK00779 509170004084 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 509170004085 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 509170004086 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509170004087 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509170004088 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 509170004089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509170004090 active site 509170004091 phosphorylation site [posttranslational modification] 509170004092 intermolecular recognition site; other site 509170004093 dimerization interface [polypeptide binding]; other site 509170004094 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170004095 Walker A motif; other site 509170004096 ATP binding site [chemical binding]; other site 509170004097 Walker B motif; other site 509170004098 arginine finger; other site 509170004099 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 509170004100 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 509170004101 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509170004102 putative active site [active] 509170004103 heme pocket [chemical binding]; other site 509170004104 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509170004105 dimer interface [polypeptide binding]; other site 509170004106 phosphorylation site [posttranslational modification] 509170004107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509170004108 ATP binding site [chemical binding]; other site 509170004109 Mg2+ binding site [ion binding]; other site 509170004110 G-X-G motif; other site 509170004111 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 509170004112 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 509170004113 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 509170004114 FeS/SAM binding site; other site 509170004115 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 509170004116 putative nucleotide binding site [chemical binding]; other site 509170004117 uridine monophosphate binding site [chemical binding]; other site 509170004118 homohexameric interface [polypeptide binding]; other site 509170004119 ribosome recycling factor; Reviewed; Region: frr; PRK00083 509170004120 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 509170004121 hinge region; other site 509170004122 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 509170004123 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 509170004124 catalytic residue [active] 509170004125 putative FPP diphosphate binding site; other site 509170004126 putative FPP binding hydrophobic cleft; other site 509170004127 dimer interface [polypeptide binding]; other site 509170004128 putative IPP diphosphate binding site; other site 509170004129 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 509170004130 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 509170004131 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 509170004132 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 509170004133 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 509170004134 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 509170004135 zinc metallopeptidase RseP; Provisional; Region: PRK10779 509170004136 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 509170004137 active site 509170004138 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 509170004139 protein binding site [polypeptide binding]; other site 509170004140 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 509170004141 protein binding site [polypeptide binding]; other site 509170004142 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 509170004143 putative substrate binding region [chemical binding]; other site 509170004144 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 509170004145 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 509170004146 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 509170004147 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 509170004148 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 509170004149 Surface antigen; Region: Bac_surface_Ag; pfam01103 509170004150 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 509170004151 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 509170004152 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 509170004153 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 509170004154 trimer interface [polypeptide binding]; other site 509170004155 active site 509170004156 UDP-GlcNAc binding site [chemical binding]; other site 509170004157 lipid binding site [chemical binding]; lipid-binding site 509170004158 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 509170004159 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 509170004160 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 509170004161 active site 509170004162 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 509170004163 recombination regulator RecX; Reviewed; Region: recX; PRK00117 509170004164 recombinase A; Provisional; Region: recA; PRK09354 509170004165 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 509170004166 hexamer interface [polypeptide binding]; other site 509170004167 Walker A motif; other site 509170004168 ATP binding site [chemical binding]; other site 509170004169 Walker B motif; other site 509170004170 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 509170004171 RNA binding surface [nucleotide binding]; other site 509170004172 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of haloacid dehalogenase-like hydrolase (part 2) 509170004173 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of haloacid dehalogenase-like hydrolase (part 1) 509170004174 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 509170004175 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 509170004176 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170004177 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004178 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 509170004179 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 509170004180 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 509170004181 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 509170004182 putative DNA binding site [nucleotide binding]; other site 509170004183 putative Zn2+ binding site [ion binding]; other site 509170004184 AsnC family; Region: AsnC_trans_reg; pfam01037 509170004185 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 509170004186 kynureninase; Region: kynureninase; TIGR01814 509170004187 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 509170004188 catalytic residue [active] 509170004189 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 509170004190 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170004191 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004192 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004193 Cupin superfamily protein; Region: Cupin_4; pfam08007 509170004194 Maf-like protein; Region: Maf; pfam02545 509170004195 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 509170004196 active site 509170004197 dimer interface [polypeptide binding]; other site 509170004198 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 509170004199 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 509170004200 Phosphoglycerate kinase; Region: PGK; pfam00162 509170004201 substrate binding site [chemical binding]; other site 509170004202 hinge regions; other site 509170004203 ADP binding site [chemical binding]; other site 509170004204 catalytic site [active] 509170004205 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 509170004206 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 509170004207 intersubunit interface [polypeptide binding]; other site 509170004208 active site 509170004209 zinc binding site [ion binding]; other site 509170004210 Na+ binding site [ion binding]; other site 509170004211 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 509170004212 SurA N-terminal domain; Region: SurA_N; pfam09312 509170004213 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 509170004214 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 509170004215 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 509170004216 OstA-like protein; Region: OstA; cl00844 509170004217 Organic solvent tolerance protein; Region: OstA_C; pfam04453 509170004218 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 509170004219 Phosphotransferase enzyme family; Region: APH; pfam01636 509170004220 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 509170004221 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 509170004222 Substrate binding site; other site 509170004223 metal-binding site 509170004224 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 509170004225 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 509170004226 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 509170004227 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 509170004228 P-loop; other site 509170004229 Magnesium ion binding site [ion binding]; other site 509170004230 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 509170004231 Magnesium ion binding site [ion binding]; other site 509170004232 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 509170004233 ParB-like nuclease domain; Region: ParB; smart00470 509170004234 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 509170004235 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of biopolymer transport protein (EXBD-like) 509170004236 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 509170004237 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 509170004238 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 509170004239 Walker A/P-loop; other site 509170004240 ATP binding site [chemical binding]; other site 509170004241 Q-loop/lid; other site 509170004242 ABC transporter signature motif; other site 509170004243 Walker B; other site 509170004244 D-loop; other site 509170004245 H-loop/switch region; other site 509170004246 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 509170004247 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 509170004248 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 509170004249 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 509170004250 Ligand binding site; other site 509170004251 oligomer interface; other site 509170004252 DNA polymerase III subunit delta'; Validated; Region: PRK05707 509170004253 PilZ domain; Region: PilZ; cl01260 509170004254 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 509170004255 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 509170004256 active site 509170004257 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509170004258 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509170004259 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 509170004260 type II secretion system protein J; Region: gspJ; TIGR01711 509170004261 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 509170004262 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 509170004263 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 509170004264 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 509170004265 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 509170004266 ligand binding site [chemical binding]; other site 509170004267 active site 509170004268 UGI interface [polypeptide binding]; other site 509170004269 catalytic site [active] 509170004270 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 509170004271 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 509170004272 substrate binding site [chemical binding]; other site 509170004273 oxyanion hole (OAH) forming residues; other site 509170004274 trimer interface [polypeptide binding]; other site 509170004275 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 509170004276 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 509170004277 nucleoside/Zn binding site; other site 509170004278 dimer interface [polypeptide binding]; other site 509170004279 catalytic motif [active] 509170004280 cytidylate kinase; Provisional; Region: cmk; PRK00023 509170004281 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 509170004282 CMP-binding site; other site 509170004283 The sites determining sugar specificity; other site 509170004284 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 509170004285 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 509170004286 RNA binding site [nucleotide binding]; other site 509170004287 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 509170004288 RNA binding site [nucleotide binding]; other site 509170004289 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 509170004290 RNA binding site [nucleotide binding]; other site 509170004291 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 509170004292 RNA binding site [nucleotide binding]; other site 509170004293 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 509170004294 RNA binding site [nucleotide binding]; other site 509170004295 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 509170004296 RNA binding site [nucleotide binding]; other site 509170004297 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 509170004298 IHF dimer interface [polypeptide binding]; other site 509170004299 IHF - DNA interface [nucleotide binding]; other site 509170004300 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 509170004301 active site 509170004302 dimer interface [polypeptide binding]; other site 509170004303 Membrane protein of unknown function (DUF340); Region: DUF340; cl01028 509170004304 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004305 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004306 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of flavin-binding monooxygenase (partial) 509170004307 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 509170004308 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 509170004309 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509170004310 Predicted ATPase [General function prediction only]; Region: COG1485 509170004311 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 509170004312 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 509170004313 active site 509170004314 DNA binding site [nucleotide binding] 509170004315 Int/Topo IB signature motif; other site 509170004316 Prophage antirepressor [Transcription]; Region: COG3617 509170004317 BRO family, N-terminal domain; Region: Bro-N; smart01040 509170004318 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 509170004319 ERF superfamily; Region: ERF; pfam04404 509170004320 replicative DNA helicase; Provisional; Region: PRK08840 509170004321 hypothetical protein; Provisional; Region: PRK09946 509170004322 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 509170004323 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 509170004324 Domain of unknown function (DUF955); Region: DUF955; cl01076 509170004325 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 509170004326 non-specific DNA binding site [nucleotide binding]; other site 509170004327 salt bridge; other site 509170004328 sequence-specific DNA binding site [nucleotide binding]; other site 509170004329 Predicted transcriptional regulator [Transcription]; Region: COG2932 509170004330 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 509170004331 Catalytic site [active] 509170004332 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 509170004333 Surface antigen [General function prediction only]; Region: COG3942 509170004334 Terminase small subunit; Region: Terminase_2; pfam03592 509170004335 Phage terminase large subunit; Region: Terminase_3; cl12054 509170004336 Terminase-like family; Region: Terminase_6; pfam03237 509170004337 Domain of unknown function (DUF4055); Region: DUF4055; pfam13264 509170004338 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 509170004339 Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554 509170004340 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170004341 hypothetical protein; Provisional; Region: PRK10040 509170004342 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 509170004343 Arc-like DNA binding domain; Region: Arc; pfam03869 509170004344 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 509170004345 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 509170004346 tape measure domain; Region: tape_meas_nterm; TIGR02675 509170004347 Phage-related minor tail protein [Function unknown]; Region: COG5281 509170004348 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 509170004349 N-acetyl-D-glucosamine binding site [chemical binding]; other site 509170004350 catalytic residue [active] 509170004351 Domain of unknown function (DUF1833); Region: DUF1833; pfam08875 509170004352 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; COG3808 509170004353 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 509170004354 catalytic residues [active] 509170004355 PAAR motif; Region: PAAR_motif; pfam05488 509170004356 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170004357 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004358 malate synthase G; Provisional; Region: PRK02999 509170004359 active site 509170004360 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 509170004361 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 509170004362 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 509170004363 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 509170004364 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 509170004365 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 509170004366 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 509170004367 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509170004368 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509170004369 N-terminal plug; other site 509170004370 ligand-binding site [chemical binding]; other site 509170004371 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505 509170004372 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 509170004373 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505 509170004374 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 509170004375 Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; Region: M3A_TOP; cd06455 509170004376 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 509170004377 active site 509170004378 Zn binding site [ion binding]; other site 509170004379 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 509170004380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 509170004381 dimer interface [polypeptide binding]; other site 509170004382 conserved gate region; other site 509170004383 putative PBP binding loops; other site 509170004384 ABC-ATPase subunit interface; other site 509170004385 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 509170004386 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 509170004387 dimer interface [polypeptide binding]; other site 509170004388 conserved gate region; other site 509170004389 putative PBP binding loops; other site 509170004390 ABC-ATPase subunit interface; other site 509170004391 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 509170004392 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 509170004393 Walker A/P-loop; other site 509170004394 ATP binding site [chemical binding]; other site 509170004395 Q-loop/lid; other site 509170004396 ABC transporter signature motif; other site 509170004397 Walker B; other site 509170004398 D-loop; other site 509170004399 H-loop/switch region; other site 509170004400 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 509170004401 Walker A/P-loop; other site 509170004402 ATP binding site [chemical binding]; other site 509170004403 Q-loop/lid; other site 509170004404 ABC transporter signature motif; other site 509170004405 Walker B; other site 509170004406 D-loop; other site 509170004407 H-loop/switch region; other site 509170004408 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 509170004409 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 509170004410 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 509170004411 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 509170004412 active site 509170004413 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 509170004414 catalytic core [active] 509170004415 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 509170004416 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 509170004417 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 509170004418 NAD binding site [chemical binding]; other site 509170004419 active site 509170004420 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 509170004421 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 509170004422 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004423 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004424 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170004425 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170004426 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170004427 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004428 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170004429 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004430 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004431 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 509170004432 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 509170004433 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 509170004434 ATP binding site [chemical binding]; other site 509170004435 putative Mg++ binding site [ion binding]; other site 509170004436 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 509170004437 nucleotide binding region [chemical binding]; other site 509170004438 ATP-binding site [chemical binding]; other site 509170004439 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 509170004440 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 509170004441 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004442 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004443 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170004444 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of adenylate or guanylate cyclase (partial) 509170004445 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 509170004446 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 509170004447 catalytic loop [active] 509170004448 iron binding site [ion binding]; other site 509170004449 chaperone protein HscA; Provisional; Region: hscA; PRK05183 509170004450 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 509170004451 nucleotide binding site [chemical binding]; other site 509170004452 putative NEF/HSP70 interaction site [polypeptide binding]; other site 509170004453 SBD interface [polypeptide binding]; other site 509170004454 co-chaperone HscB; Provisional; Region: hscB; PRK05014 509170004455 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 509170004456 HSP70 interaction site [polypeptide binding]; other site 509170004457 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 509170004458 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 509170004459 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 509170004460 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 509170004461 trimerization site [polypeptide binding]; other site 509170004462 active site 509170004463 cysteine desulfurase; Provisional; Region: PRK14012 509170004464 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 509170004465 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 509170004466 catalytic residue [active] 509170004467 Transcriptional regulator; Region: Rrf2; cl17282 509170004468 Rrf2 family protein; Region: rrf2_super; TIGR00738 509170004469 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597 509170004470 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 509170004471 IHF dimer interface [polypeptide binding]; other site 509170004472 IHF - DNA interface [nucleotide binding]; other site 509170004473 periplasmic folding chaperone; Provisional; Region: PRK10788 509170004474 SurA N-terminal domain; Region: SurA_N_3; cl07813 509170004475 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 509170004476 Cupin; Region: Cupin_6; pfam12852 509170004477 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 509170004478 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509170004479 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 509170004480 Fatty acid desaturase; Region: FA_desaturase; pfam00487 509170004481 Di-iron ligands [ion binding]; other site 509170004482 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 509170004483 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509170004484 active site 509170004485 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 509170004486 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509170004487 active site 509170004488 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 509170004489 ABC1 family; Region: ABC1; cl17513 509170004490 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170004491 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170004492 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 509170004493 IucA / IucC family; Region: IucA_IucC; pfam04183 509170004494 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 509170004495 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004496 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004497 Protein of unknown function (DUF1018); Region: DUF1018; pfam06252 509170004498 Mor transcription activator family; Region: Mor; cl02360 509170004499 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 509170004500 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 509170004501 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 509170004502 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 509170004503 motif II; other site 509170004504 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 509170004505 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 509170004506 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 509170004507 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 509170004508 homotrimer interface [polypeptide binding]; other site 509170004509 Walker A motif; other site 509170004510 GTP binding site [chemical binding]; other site 509170004511 Walker B motif; other site 509170004512 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (NN:DBI PRT) (N(1)-alpha-phosphoribosyltransferase) (CobT) (part 1) 509170004513 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (NN:DBI PRT) (N(1)-alpha-phosphoribosyltransferase) (CobT) (part 2) 509170004514 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 509170004515 catalytic core [active] 509170004516 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 509170004517 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of cobalamin 5'-phosphate synthase (CobS) (part 1) 509170004518 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of cobalamin 5'-phosphate synthase (CobS) (part 2) 509170004519 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 509170004520 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 509170004521 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 509170004522 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004523 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004524 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 509170004525 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 509170004526 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509170004527 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509170004528 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 509170004529 Evidence 7 : Gene remnant; Product type pm : membrane component; fragment of membrane fusion protein (part 1) 509170004530 Evidence 7 : Gene remnant; Product type pm : membrane component; fragment of membrane fusion protein (part 2) 509170004531 Evidence 7 : Gene remnant; Product type pm : membrane component; fragment of membrane fusion protein (part 3) 509170004532 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 509170004533 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 509170004534 Walker A/P-loop; other site 509170004535 ATP binding site [chemical binding]; other site 509170004536 Q-loop/lid; other site 509170004537 ABC transporter signature motif; other site 509170004538 Walker B; other site 509170004539 D-loop; other site 509170004540 H-loop/switch region; other site 509170004541 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 509170004542 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 509170004543 Walker A/P-loop; other site 509170004544 ATP binding site [chemical binding]; other site 509170004545 Q-loop/lid; other site 509170004546 ABC transporter signature motif; other site 509170004547 Walker B; other site 509170004548 D-loop; other site 509170004549 H-loop/switch region; other site 509170004550 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 509170004551 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 509170004552 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 509170004553 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 509170004554 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 509170004555 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170004556 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 509170004557 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 509170004558 eyelet of channel; other site 509170004559 trimer interface [polypeptide binding]; other site 509170004560 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 509170004561 HIT family signature motif; other site 509170004562 catalytic residue [active] 509170004563 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004564 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004565 Uncharacterized conserved protein [Function unknown]; Region: COG3791 509170004566 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170004567 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004568 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170004569 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170004570 Methyltransferase domain; Region: Methyltransf_23; pfam13489 509170004571 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509170004572 S-adenosylmethionine binding site [chemical binding]; other site 509170004573 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 509170004574 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 509170004575 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 509170004576 homodimer interface [polypeptide binding]; other site 509170004577 substrate-cofactor binding pocket; other site 509170004578 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170004579 catalytic residue [active] 509170004580 hypothetical protein; Validated; Region: PRK00153 509170004581 recombination protein RecR; Reviewed; Region: recR; PRK00076 509170004582 RecR protein; Region: RecR; pfam02132 509170004583 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 509170004584 putative active site [active] 509170004585 putative metal-binding site [ion binding]; other site 509170004586 tetramer interface [polypeptide binding]; other site 509170004587 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 509170004588 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 509170004589 catalytic site [active] 509170004590 putative active site [active] 509170004591 putative substrate binding site [chemical binding]; other site 509170004592 HRDC domain; Region: HRDC; pfam00570 509170004593 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004594 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004595 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170004596 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004597 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170004598 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170004599 YcgL domain; Region: YcgL; pfam05166 509170004600 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170004601 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 509170004602 Walker A motif; other site 509170004603 ATP binding site [chemical binding]; other site 509170004604 Walker B motif; other site 509170004605 arginine finger; other site 509170004606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 509170004607 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 509170004608 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 509170004609 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170004610 catalytic residue [active] 509170004611 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004612 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004613 HemK family putative methylases; Region: hemK_fam; TIGR00536 509170004614 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509170004615 S-adenosylmethionine binding site [chemical binding]; other site 509170004616 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 509170004617 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 509170004618 Tetramer interface [polypeptide binding]; other site 509170004619 active site 509170004620 FMN-binding site [chemical binding]; other site 509170004621 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004622 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004623 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of dihydrolipoamide dehydrogenase (E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes) (partial) 509170004624 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 509170004625 acetoin reductases; Region: 23BDH; TIGR02415 509170004626 NAD binding site [chemical binding]; other site 509170004627 homotetramer interface [polypeptide binding]; other site 509170004628 homodimer interface [polypeptide binding]; other site 509170004629 active site 509170004630 substrate binding site [chemical binding]; other site 509170004631 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 509170004632 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 509170004633 putative NAD(P) binding site [chemical binding]; other site 509170004634 catalytic Zn binding site [ion binding]; other site 509170004635 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 509170004636 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170004637 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 509170004638 Walker A motif; other site 509170004639 ATP binding site [chemical binding]; other site 509170004640 Walker B motif; other site 509170004641 arginine finger; other site 509170004642 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 509170004643 Putative phosphatase (DUF442); Region: DUF442; cl17385 509170004644 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 509170004645 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 509170004646 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 509170004647 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 509170004648 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 509170004649 EamA-like transporter family; Region: EamA; pfam00892 509170004650 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 509170004651 EamA-like transporter family; Region: EamA; pfam00892 509170004652 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004653 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004654 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170004655 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170004656 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170004657 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170004658 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 509170004659 non-specific DNA binding site [nucleotide binding]; other site 509170004660 salt bridge; other site 509170004661 sequence-specific DNA binding site [nucleotide binding]; other site 509170004662 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170004663 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170004664 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of Outer membrane protein (partial) 509170004665 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of acyl-CoA synthetase (long-chain-fatty-acid--CoA ligase) (part 1) 509170004666 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of acyl-CoA synthetase (long-chain-fatty-acid--CoA ligase) (part 2) 509170004667 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 509170004668 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 509170004669 intersubunit interface [polypeptide binding]; other site 509170004670 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 509170004671 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 509170004672 ABC-ATPase subunit interface; other site 509170004673 dimer interface [polypeptide binding]; other site 509170004674 putative PBP binding regions; other site 509170004675 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 509170004676 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 509170004677 Walker A/P-loop; other site 509170004678 ATP binding site [chemical binding]; other site 509170004679 Q-loop/lid; other site 509170004680 ABC transporter signature motif; other site 509170004681 Walker B; other site 509170004682 D-loop; other site 509170004683 H-loop/switch region; other site 509170004684 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 509170004685 Coenzyme A binding pocket [chemical binding]; other site 509170004686 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; fragment of Transcriptional regulator (AraC family) (part 2) 509170004687 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004688 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004689 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; fragment of Transcriptional regulator (AraC family) (part 1) 509170004690 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 509170004691 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 509170004692 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 509170004693 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 509170004694 active site 509170004695 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 509170004696 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 509170004697 active site 509170004698 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 509170004699 nudix motif; other site 509170004700 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 509170004701 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 509170004702 FAD binding site [chemical binding]; other site 509170004703 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 509170004704 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170004705 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170004706 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004707 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of transcriptional regulator (partial) 509170004708 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 509170004709 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 509170004710 catalytic loop [active] 509170004711 iron binding site [ion binding]; other site 509170004712 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 509170004713 FAD binding pocket [chemical binding]; other site 509170004714 FAD binding motif [chemical binding]; other site 509170004715 phosphate binding motif [ion binding]; other site 509170004716 beta-alpha-beta structure motif; other site 509170004717 NAD binding pocket [chemical binding]; other site 509170004718 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 509170004719 inter-subunit interface; other site 509170004720 anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228 509170004721 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 509170004722 [2Fe-2S] cluster binding site [ion binding]; other site 509170004723 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 509170004724 putative alpha subunit interface [polypeptide binding]; other site 509170004725 putative active site [active] 509170004726 putative substrate binding site [chemical binding]; other site 509170004727 Fe binding site [ion binding]; other site 509170004728 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of repressor of the modABC operon for molybdenum transport (ModE) (part 1) 509170004729 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of repressor of the modABC operon for molybdenum transport (ModE) (part 2) 509170004730 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004731 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004732 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of Ferric uptake regulator (partial) 509170004733 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 509170004734 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 509170004735 putative active site [active] 509170004736 putative metal binding site [ion binding]; other site 509170004737 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 509170004738 polyphosphate kinase; Provisional; Region: PRK05443 509170004739 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 509170004740 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 509170004741 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 509170004742 putative active site [active] 509170004743 catalytic site [active] 509170004744 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 509170004745 putative domain interface [polypeptide binding]; other site 509170004746 putative active site [active] 509170004747 catalytic site [active] 509170004748 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 509170004749 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 509170004750 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 509170004751 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 509170004752 pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079 509170004753 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 509170004754 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 509170004755 FeS/SAM binding site; other site 509170004756 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 509170004757 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 509170004758 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 509170004759 active site 509170004760 dimer interface [polypeptide binding]; other site 509170004761 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004762 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004763 Zonular occludens toxin (Zot); Region: Zot; cl17485 509170004764 Protein of unknown function (DUF2523); Region: DUF2523; cl10291 509170004765 Neisseria meningitidis TspB protein; Region: Neisseria_TspB; pfam05616 509170004766 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004767 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004768 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of Transcriptional regulator (GntR family) (partial) 509170004769 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; pfam09694 509170004770 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 509170004771 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509170004772 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509170004773 dimerization interface [polypeptide binding]; other site 509170004774 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 509170004775 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 509170004776 octamer interface [polypeptide binding]; other site 509170004777 active site 509170004778 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 509170004779 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 509170004780 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 509170004781 dimer interface [polypeptide binding]; other site 509170004782 active site 509170004783 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 509170004784 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 509170004785 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 509170004786 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 509170004787 dimer interface [polypeptide binding]; other site 509170004788 active site 509170004789 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 509170004790 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 509170004791 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170004792 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004793 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004794 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of acyl-CoA dehydrogenase (partial) 509170004795 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of transcriptional regulator (LysR family) (partial) 509170004796 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 509170004797 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 509170004798 Bacterial transcriptional regulator; Region: IclR; pfam01614 509170004799 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170004800 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170004801 Predicted transporter component [General function prediction only]; Region: COG2391 509170004802 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 509170004803 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 509170004804 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 509170004805 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 509170004806 Trp docking motif [polypeptide binding]; other site 509170004807 putative active site [active] 509170004808 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 509170004809 Right handed beta helix region; Region: Beta_helix; pfam13229 509170004810 Evidence 7 : Gene remnant; PubMedId : 7592351; Product type e : enzyme; fragment of catabolic 3-dehydroquinate dehydratase (3-dehydroquinase) (QuiB) (part 2) 509170004811 Evidence 7 : Gene remnant; PubMedId : 7592351; Product type e : enzyme; fragment of catabolic 3-dehydroquinate dehydratase (3-dehydroquinase)(QuiB) (part 1) 509170004812 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 509170004813 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 509170004814 heterodimer interface [polypeptide binding]; other site 509170004815 active site 509170004816 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 509170004817 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 509170004818 active site 509170004819 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 509170004820 benzoate transport; Region: 2A0115; TIGR00895 509170004821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170004822 putative substrate translocation pore; other site 509170004823 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170004824 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 509170004825 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 509170004826 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 509170004827 tetramer interface [polypeptide binding]; other site 509170004828 active site 509170004829 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 509170004830 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 509170004831 dimer interface [polypeptide binding]; other site 509170004832 active site 509170004833 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 509170004834 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 509170004835 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 509170004836 substrate binding site; other site 509170004837 dimer interface; other site 509170004838 Septum formation initiator; Region: DivIC; cl17659 509170004839 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 509170004840 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004841 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004842 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170004843 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170004844 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004845 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170004846 enolase; Provisional; Region: eno; PRK00077 509170004847 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 509170004848 dimer interface [polypeptide binding]; other site 509170004849 metal binding site [ion binding]; metal-binding site 509170004850 substrate binding pocket [chemical binding]; other site 509170004851 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 509170004852 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 509170004853 CTP synthetase; Validated; Region: pyrG; PRK05380 509170004854 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 509170004855 Catalytic site [active] 509170004856 active site 509170004857 UTP binding site [chemical binding]; other site 509170004858 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 509170004859 active site 509170004860 putative oxyanion hole; other site 509170004861 catalytic triad [active] 509170004862 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 509170004863 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 509170004864 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 509170004865 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 509170004866 active site 509170004867 catalytic triad [active] 509170004868 oxyanion hole [active] 509170004869 SnoaL-like domain; Region: SnoaL_2; pfam12680 509170004870 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of 2,4-dienoyl-CoA reductase (part 4) 509170004871 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of 2,4-dienoyl-CoA reductase (part 3) 509170004872 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of 2,4-dienoyl-CoA reductase (part 2) 509170004873 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of 2,4-dienoyl-CoA reductase (part 1) 509170004874 Predicted transcriptional regulators [Transcription]; Region: COG1695 509170004875 Transcriptional regulator PadR-like family; Region: PadR; cl17335 509170004876 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 509170004877 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 509170004878 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 509170004879 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 509170004880 hypothetical protein; Provisional; Region: PRK02237 509170004881 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 509170004882 Clp amino terminal domain; Region: Clp_N; pfam02861 509170004883 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170004884 Walker A motif; other site 509170004885 ATP binding site [chemical binding]; other site 509170004886 Walker B motif; other site 509170004887 arginine finger; other site 509170004888 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170004889 Walker A motif; other site 509170004890 ATP binding site [chemical binding]; other site 509170004891 Walker B motif; other site 509170004892 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 509170004893 Uncharacterized conserved protein [Function unknown]; Region: COG2127 509170004894 Membrane-anchored protein predicted to be involved in regulation of amylopullulanase [Carbohydrate transport and metabolism]; Region: COG4945 509170004895 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 509170004896 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 509170004897 Protein of unknown function DUF45; Region: DUF45; pfam01863 509170004898 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 509170004899 tetramer (dimer of dimers) interface [polypeptide binding]; other site 509170004900 active site 509170004901 dimer interface [polypeptide binding]; other site 509170004902 threonine dehydratase; Reviewed; Region: PRK09224 509170004903 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 509170004904 tetramer interface [polypeptide binding]; other site 509170004905 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170004906 catalytic residue [active] 509170004907 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 509170004908 putative Ile/Val binding site [chemical binding]; other site 509170004909 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 509170004910 putative Ile/Val binding site [chemical binding]; other site 509170004911 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 509170004912 TrkA-N domain; Region: TrkA_N; pfam02254 509170004913 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 509170004914 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 509170004915 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of phospholipase A1 precursor (PldA) (part 2) 509170004916 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of phospholipase A1 precursor (PldA) (part 1) 509170004917 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 509170004918 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 509170004919 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 509170004920 Peptidase M16C associated; Region: M16C_assoc; pfam08367 509170004921 Evidence 7 : Gene remnant; Product type prc : receptor; fragment of ferrisiderophore receptor protein, TonB dependent (part 2) 509170004922 Evidence 7 : Gene remnant; Product type prc : receptor; fragment of ferrisiderophore receptor protein, TonB dependent (part 1) 509170004923 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 509170004924 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 509170004925 substrate binding site [chemical binding]; other site 509170004926 ATP binding site [chemical binding]; other site 509170004927 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 509170004928 iron-sulfur cluster [ion binding]; other site 509170004929 [2Fe-2S] cluster binding site [ion binding]; other site 509170004930 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 509170004931 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170004932 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170004933 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 509170004934 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 509170004935 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 509170004936 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 509170004937 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 509170004938 Cyd operon protein YbgE (Cyd_oper_YbgE); Region: Cyd_oper_YbgE; pfam09600 509170004939 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of acetyltransferase (part 2) 509170004940 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004941 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004942 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of acetyltransferase (part 1) 509170004943 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829 509170004944 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170004945 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170004946 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170004947 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004948 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 509170004949 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 509170004950 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 509170004951 P loop; other site 509170004952 GTP binding site [chemical binding]; other site 509170004953 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 509170004954 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 509170004955 FOG: CBS domain [General function prediction only]; Region: COG0517 509170004956 acetylornithine aminotransferase; Provisional; Region: PRK02627 509170004957 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 509170004958 inhibitor-cofactor binding pocket; inhibition site 509170004959 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170004960 catalytic residue [active] 509170004961 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 509170004962 putative GSH binding site [chemical binding]; other site 509170004963 catalytic residues [active] 509170004964 replication factor-a protein 1 (rpa1); Region: rpa1; TIGR00617 509170004965 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004966 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004967 LysR family transcriptional regulator; Provisional; Region: PRK14997 509170004968 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509170004969 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 509170004970 putative effector binding pocket; other site 509170004971 putative dimerization interface [polypeptide binding]; other site 509170004972 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 509170004973 active site 509170004974 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 509170004975 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004976 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004977 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170004978 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 509170004979 dimerization interface [polypeptide binding]; other site 509170004980 putative DNA binding site [nucleotide binding]; other site 509170004981 putative Zn2+ binding site [ion binding]; other site 509170004982 serine/threonine transporter SstT; Provisional; Region: PRK13628 509170004983 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 509170004984 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 509170004985 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831 509170004986 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 509170004987 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 509170004988 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 509170004989 Walker A/P-loop; other site 509170004990 ATP binding site [chemical binding]; other site 509170004991 Q-loop/lid; other site 509170004992 ABC transporter signature motif; other site 509170004993 Walker B; other site 509170004994 D-loop; other site 509170004995 H-loop/switch region; other site 509170004996 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 509170004997 putative active site [active] 509170004998 putative catalytic site [active] 509170004999 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 509170005000 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 509170005001 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509170005002 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 509170005003 lipoyl attachment site [posttranslational modification]; other site 509170005004 NAD-dependent deacetylase; Provisional; Region: PRK00481 509170005005 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 509170005006 NAD+ binding site [chemical binding]; other site 509170005007 substrate binding site [chemical binding]; other site 509170005008 Zn binding site [ion binding]; other site 509170005009 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170005010 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005011 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 509170005012 Na binding site [ion binding]; other site 509170005013 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 509170005014 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 509170005015 dimerization interface [polypeptide binding]; other site 509170005016 putative DNA binding site [nucleotide binding]; other site 509170005017 putative Zn2+ binding site [ion binding]; other site 509170005018 AsnC family; Region: AsnC_trans_reg; pfam01037 509170005019 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 509170005020 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 509170005021 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 509170005022 Glutamate binding site [chemical binding]; other site 509170005023 NAD binding site [chemical binding]; other site 509170005024 catalytic residues [active] 509170005025 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170005026 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005027 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005028 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170005029 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 509170005030 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509170005031 S-adenosylmethionine binding site [chemical binding]; other site 509170005032 Predicted periplasmic protein [Function unknown]; Region: COG3698 509170005033 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 509170005034 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 509170005035 Uncharacterized conserved protein [Function unknown]; Region: COG2353 509170005036 OsmC-like protein; Region: OsmC; pfam02566 509170005037 transketolase; Reviewed; Region: PRK12753 509170005038 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 509170005039 TPP-binding site [chemical binding]; other site 509170005040 dimer interface [polypeptide binding]; other site 509170005041 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 509170005042 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 509170005043 PYR/PP interface [polypeptide binding]; other site 509170005044 dimer interface [polypeptide binding]; other site 509170005045 TPP binding site [chemical binding]; other site 509170005046 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 509170005047 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005048 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005049 S-adenosylmethionine synthetase; Validated; Region: PRK05250 509170005050 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 509170005051 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 509170005052 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 509170005053 N2,N2-dimethylguanosine tRNA methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TRM1; COG1867 509170005054 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 509170005055 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 509170005056 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 509170005057 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 509170005058 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 509170005059 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 509170005060 non-specific DNA binding site [nucleotide binding]; other site 509170005061 salt bridge; other site 509170005062 sequence-specific DNA binding site [nucleotide binding]; other site 509170005063 Cupin domain; Region: Cupin_2; cl17218 509170005064 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 509170005065 active site 509170005066 putative DNA-binding cleft [nucleotide binding]; other site 509170005067 dimer interface [polypeptide binding]; other site 509170005068 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170005069 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170005070 epoxyqueuosine reductase; Region: TIGR00276 509170005071 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 509170005072 biotin synthase; Provisional; Region: PRK15108 509170005073 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 509170005074 FeS/SAM binding site; other site 509170005075 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 509170005076 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005077 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005078 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509170005079 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509170005080 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509170005081 dimerization interface [polypeptide binding]; other site 509170005082 EamA-like transporter family; Region: EamA; pfam00892 509170005083 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 509170005084 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 509170005085 Na binding site [ion binding]; other site 509170005086 Predicted membrane protein [Function unknown]; Region: COG4125 509170005087 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 509170005088 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 509170005089 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509170005090 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509170005091 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 509170005092 dimerization interface [polypeptide binding]; other site 509170005093 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005094 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005095 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of phage integrase (part 2) 509170005096 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170005097 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005098 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of phage integrase (part 1) 509170005099 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170005100 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170005101 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 509170005102 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 509170005103 putative acyl-acceptor binding pocket; other site 509170005104 hypothetical protein; Validated; Region: PRK00110 509170005105 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 509170005106 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 509170005107 putative DNA binding site [nucleotide binding]; other site 509170005108 putative Zn2+ binding site [ion binding]; other site 509170005109 AsnC family; Region: AsnC_trans_reg; pfam01037 509170005110 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005111 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005112 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170005113 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005114 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 509170005115 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 509170005116 C-terminal domain interface [polypeptide binding]; other site 509170005117 GSH binding site (G-site) [chemical binding]; other site 509170005118 dimer interface [polypeptide binding]; other site 509170005119 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 509170005120 N-terminal domain interface [polypeptide binding]; other site 509170005121 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 509170005122 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509170005123 active site 509170005124 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 509170005125 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 509170005126 Flavin binding site [chemical binding]; other site 509170005127 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 509170005128 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 509170005129 active site 509170005130 non-prolyl cis peptide bond; other site 509170005131 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 509170005132 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 509170005133 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 509170005134 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 509170005135 Walker A/P-loop; other site 509170005136 ATP binding site [chemical binding]; other site 509170005137 Q-loop/lid; other site 509170005138 ABC transporter signature motif; other site 509170005139 Walker B; other site 509170005140 D-loop; other site 509170005141 H-loop/switch region; other site 509170005142 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 509170005143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 509170005144 dimer interface [polypeptide binding]; other site 509170005145 conserved gate region; other site 509170005146 ABC-ATPase subunit interface; other site 509170005147 GTP-binding protein YchF; Reviewed; Region: PRK09601 509170005148 YchF GTPase; Region: YchF; cd01900 509170005149 G1 box; other site 509170005150 GTP/Mg2+ binding site [chemical binding]; other site 509170005151 Switch I region; other site 509170005152 G2 box; other site 509170005153 Switch II region; other site 509170005154 G3 box; other site 509170005155 G4 box; other site 509170005156 G5 box; other site 509170005157 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 509170005158 Predicted membrane protein [Function unknown]; Region: COG4539 509170005159 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 509170005160 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 509170005161 ligand binding site [chemical binding]; other site 509170005162 flexible hinge region; other site 509170005163 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 509170005164 putative switch regulator; other site 509170005165 non-specific DNA interactions [nucleotide binding]; other site 509170005166 DNA binding site [nucleotide binding] 509170005167 sequence specific DNA binding site [nucleotide binding]; other site 509170005168 putative cAMP binding site [chemical binding]; other site 509170005169 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170005170 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005171 AzlC protein; Region: AzlC; cl00570 509170005172 putative L-valine exporter; Provisional; Region: PRK10408 509170005173 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cl01268 509170005174 trimer interface [polypeptide binding]; other site 509170005175 putative substrate binding pocket [chemical binding]; other site 509170005176 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 509170005177 active site 1 [active] 509170005178 dimer interface [polypeptide binding]; other site 509170005179 hexamer interface [polypeptide binding]; other site 509170005180 active site 2 [active] 509170005181 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 509170005182 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170005183 ATP-grasp domain; Region: ATP-grasp; pfam02222 509170005184 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 509170005185 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 509170005186 metal binding triad; other site 509170005187 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 509170005188 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 509170005189 Zn2+ binding site [ion binding]; other site 509170005190 Mg2+ binding site [ion binding]; other site 509170005191 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 509170005192 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 509170005193 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 509170005194 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 509170005195 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170005196 homodimer interface [polypeptide binding]; other site 509170005197 catalytic residue [active] 509170005198 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of amino acid efflux protein, threonine efflux protein (part 2) 509170005199 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of amino acid efflux protein, threonine efflux protein (part 1) 509170005200 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 509170005201 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 509170005202 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509170005203 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 509170005204 catalytic residues [active] 509170005205 dimer interface [polypeptide binding]; other site 509170005206 methionine sulfoxide reductase B; Provisional; Region: PRK00222 509170005207 SelR domain; Region: SelR; pfam01641 509170005208 aminotransferase AlaT; Validated; Region: PRK09265 509170005209 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 509170005210 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170005211 homodimer interface [polypeptide binding]; other site 509170005212 catalytic residue [active] 509170005213 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005214 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005215 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 509170005216 active site 509170005217 homodimer interface [polypeptide binding]; other site 509170005218 homotetramer interface [polypeptide binding]; other site 509170005219 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170005220 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005221 NMT1-like family; Region: NMT1_2; pfam13379 509170005222 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 509170005223 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of DNA-repair protein (UmuC-like) (part 1) 509170005224 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of DNA-repair protein (UmuC-like) (part 2) 509170005225 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 509170005226 Dehydroquinase class II; Region: DHquinase_II; pfam01220 509170005227 trimer interface [polypeptide binding]; other site 509170005228 active site 509170005229 dimer interface [polypeptide binding]; other site 509170005230 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 509170005231 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 509170005232 carboxyltransferase (CT) interaction site; other site 509170005233 biotinylation site [posttranslational modification]; other site 509170005234 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 509170005235 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 509170005236 ATP-grasp domain; Region: ATP-grasp_4; cl17255 509170005237 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 509170005238 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005239 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005240 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509170005241 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509170005242 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170005243 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170005244 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005245 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170005246 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 509170005247 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 509170005248 Uncharacterized conserved protein [Function unknown]; Region: COG1434 509170005249 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 509170005250 putative active site [active] 509170005251 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 509170005252 FAD binding domain; Region: FAD_binding_4; pfam01565 509170005253 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 509170005254 Low molecular weight phosphatase family; Region: LMWPc; cd00115 509170005255 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 509170005256 active site 509170005257 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 509170005258 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170005259 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005260 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 509170005261 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 509170005262 putative active site [active] 509170005263 metal binding site [ion binding]; metal-binding site 509170005264 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 509170005265 active site 509170005266 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 509170005267 Phosphoesterase family; Region: Phosphoesterase; pfam04185 509170005268 Domain of unknown function (DUF756); Region: DUF756; pfam05506 509170005269 Domain of unknown function (DUF756); Region: DUF756; pfam05506 509170005270 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14960 509170005271 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170005272 Walker A motif; other site 509170005273 ATP binding site [chemical binding]; other site 509170005274 Walker B motif; other site 509170005275 arginine finger; other site 509170005276 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 509170005277 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 509170005278 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170005279 putative substrate translocation pore; other site 509170005280 TetR family transcriptional regulator; Provisional; Region: PRK14996 509170005281 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509170005282 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 509170005283 Beta-lactamase; Region: Beta-lactamase; pfam00144 509170005284 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 509170005285 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 509170005286 active site 2 [active] 509170005287 active site 1 [active] 509170005288 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 509170005289 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170005290 NAD(P) binding site [chemical binding]; other site 509170005291 active site 509170005292 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 509170005293 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 509170005294 dimer interface [polypeptide binding]; other site 509170005295 active site 509170005296 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 509170005297 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 509170005298 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509170005299 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509170005300 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 509170005301 dimerization interface [polypeptide binding]; other site 509170005302 transaldolase-like protein; Provisional; Region: PTZ00411 509170005303 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 509170005304 active site 509170005305 dimer interface [polypeptide binding]; other site 509170005306 catalytic residue [active] 509170005307 leucine export protein LeuE; Provisional; Region: PRK10958 509170005308 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 509170005309 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 509170005310 AsnC family; Region: AsnC_trans_reg; pfam01037 509170005311 Benzoate membrane transport protein; Region: BenE; pfam03594 509170005312 benzoate transporter; Region: benE; TIGR00843 509170005313 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 509170005314 MgtC family; Region: MgtC; pfam02308 509170005315 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 509170005316 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 509170005317 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 509170005318 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 509170005319 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 509170005320 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170005321 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170005322 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005323 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005324 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 509170005325 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005326 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005327 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 509170005328 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 509170005329 putative cyanate transporter; Provisional; Region: cynX; PRK09705 509170005330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170005331 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 509170005332 nucleoside/Zn binding site; other site 509170005333 dimer interface [polypeptide binding]; other site 509170005334 catalytic motif [active] 509170005335 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 509170005336 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 509170005337 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 509170005338 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 509170005339 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509170005340 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509170005341 LysR substrate binding domain; Region: LysR_substrate; pfam03466 509170005342 dimerization interface [polypeptide binding]; other site 509170005343 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 509170005344 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 509170005345 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 509170005346 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 509170005347 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 509170005348 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 509170005349 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 509170005350 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 509170005351 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170005352 Walker A motif; other site 509170005353 ATP binding site [chemical binding]; other site 509170005354 Walker B motif; other site 509170005355 arginine finger; other site 509170005356 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170005357 Walker A motif; other site 509170005358 ATP binding site [chemical binding]; other site 509170005359 Walker B motif; other site 509170005360 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 509170005361 PAAR motif; Region: PAAR_motif; pfam05488 509170005362 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 509170005363 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 509170005364 ligand binding site [chemical binding]; other site 509170005365 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 509170005366 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 509170005367 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 509170005368 G1 box; other site 509170005369 GTP/Mg2+ binding site [chemical binding]; other site 509170005370 Switch I region; other site 509170005371 G3 box; other site 509170005372 Switch II region; other site 509170005373 G4 box; other site 509170005374 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 509170005375 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 509170005376 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 509170005377 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 509170005378 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 509170005379 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 509170005380 Protein of unknown function (DUF796); Region: DUF796; pfam05638 509170005381 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 509170005382 Protein of unknown function (DUF877); Region: DUF877; pfam05943 509170005383 Protein of unknown function (DUF770); Region: DUF770; pfam05591 509170005384 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005385 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005386 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 509170005387 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 509170005388 putative Cl- selectivity filter; other site 509170005389 putative pore gating glutamate residue; other site 509170005390 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 509170005391 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 509170005392 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 509170005393 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 509170005394 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 509170005395 carboxyltransferase (CT) interaction site; other site 509170005396 biotinylation site [posttranslational modification]; other site 509170005397 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 509170005398 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 509170005399 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 509170005400 hypothetical protein; Provisional; Region: PRK05463 509170005401 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 509170005402 putative active site [active] 509170005403 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 509170005404 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170005405 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005406 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 509170005407 RHS protein; Region: RHS; pfam03527 509170005408 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 509170005409 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 509170005410 RHS Repeat; Region: RHS_repeat; pfam05593 509170005411 RHS Repeat; Region: RHS_repeat; pfam05593 509170005412 RHS Repeat; Region: RHS_repeat; pfam05593 509170005413 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 509170005414 RHS Repeat; Region: RHS_repeat; cl11982 509170005415 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 509170005416 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 509170005417 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 509170005418 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 509170005419 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 509170005420 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 509170005421 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005422 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005423 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170005424 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005425 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 509170005426 Coenzyme A binding pocket [chemical binding]; other site 509170005427 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005428 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005429 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 509170005430 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 509170005431 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005432 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005433 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170005434 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170005435 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 509170005436 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 509170005437 heme binding pocket [chemical binding]; other site 509170005438 heme ligand [chemical binding]; other site 509170005439 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 509170005440 TPR repeat; Region: TPR_11; pfam13414 509170005441 Protein of unknown function (DUF560); Region: DUF560; pfam04575 509170005442 Secretin and TonB N terminus short domain; Region: STN; pfam07660 509170005443 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 509170005444 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 509170005445 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509170005446 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of transmembrane sensor protein (iron transport) (part 2) 509170005447 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of transmembrane sensor protein (iron transport) (part 1) 509170005448 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509170005449 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 509170005450 DNA binding residues [nucleotide binding] 509170005451 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 509170005452 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; fragment of RHS-related protein (part 3) 509170005453 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; fragment of RHS-related protein (part 2) 509170005454 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; fragment of RHS-related protein (part 1) 509170005455 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170005456 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of peptide methionine sulfoxide reductase (Protein-methionine-S-oxide reductase) (Peptide Met(O) reductase) (partial) 509170005457 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 509170005458 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 509170005459 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 509170005460 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 509170005461 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170005462 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005463 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase (part 1) 509170005464 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase (part 2) 509170005465 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase (part 3) 509170005466 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase (part 4) 509170005467 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005468 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005469 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 509170005470 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 509170005471 catalytic residues [active] 509170005472 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 509170005473 DNA-binding interface [nucleotide binding]; DNA binding site 509170005474 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005475 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005476 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 509170005477 active site 509170005478 zinc binding site [ion binding]; other site 509170005479 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 509170005480 trimer interface [polypeptide binding]; other site 509170005481 active site 509170005482 substrate binding site [chemical binding]; other site 509170005483 CoA binding site [chemical binding]; other site 509170005484 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 509170005485 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 509170005486 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 509170005487 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 509170005488 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 509170005489 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 509170005490 HlyD family secretion protein; Region: HlyD_3; pfam13437 509170005491 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 509170005492 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 509170005493 putative active site [active] 509170005494 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 509170005495 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 509170005496 Walker A/P-loop; other site 509170005497 ATP binding site [chemical binding]; other site 509170005498 Q-loop/lid; other site 509170005499 ABC transporter signature motif; other site 509170005500 Walker B; other site 509170005501 D-loop; other site 509170005502 H-loop/switch region; other site 509170005503 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 509170005504 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170005505 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005506 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 509170005507 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 509170005508 Walker A/P-loop; other site 509170005509 ATP binding site [chemical binding]; other site 509170005510 Q-loop/lid; other site 509170005511 ABC transporter signature motif; other site 509170005512 Walker B; other site 509170005513 D-loop; other site 509170005514 H-loop/switch region; other site 509170005515 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 509170005516 OstA-like protein; Region: OstA; pfam03968 509170005517 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 509170005518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 509170005519 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 509170005520 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 509170005521 active site 509170005522 motif I; other site 509170005523 motif II; other site 509170005524 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 509170005525 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 509170005526 putative active site [active] 509170005527 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 509170005528 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 509170005529 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 509170005530 active site 509170005531 HIGH motif; other site 509170005532 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 509170005533 KMSKS motif; other site 509170005534 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 509170005535 tRNA binding surface [nucleotide binding]; other site 509170005536 anticodon binding site; other site 509170005537 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of integrase/recombinase protein (partial) 509170005538 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005539 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005540 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170005541 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 509170005542 Predicted transcriptional regulator [Transcription]; Region: COG2932 509170005543 non-specific DNA binding site [nucleotide binding]; other site 509170005544 salt bridge; other site 509170005545 sequence-specific DNA binding site [nucleotide binding]; other site 509170005546 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 509170005547 Catalytic site [active] 509170005548 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 509170005549 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 509170005550 generic binding surface II; other site 509170005551 generic binding surface I; other site 509170005552 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 509170005553 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170005554 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005555 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170005556 Evidence 7 : Gene remnant; Product type t : transporter; fragment of C4-dicarboxylate transport protein (partial) 509170005557 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509170005558 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509170005559 Major Facilitator Superfamily; Region: MFS_1; pfam07690 509170005560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 509170005561 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 509170005562 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 509170005563 Coenzyme A binding pocket [chemical binding]; other site 509170005564 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170005565 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005566 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 509170005567 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 509170005568 Protein of unknown function (DUF330); Region: DUF330; pfam03886 509170005569 mce related protein; Region: MCE; pfam02470 509170005570 mce related protein; Region: MCE; pfam02470 509170005571 mce related protein; Region: MCE; pfam02470 509170005572 Paraquat-inducible protein A; Region: PqiA; pfam04403 509170005573 Paraquat-inducible protein A; Region: PqiA; pfam04403 509170005574 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005575 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005576 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 509170005577 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 509170005578 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 509170005579 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170005580 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170005581 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005582 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005583 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 509170005584 Found in ATP-dependent protease La (LON); Region: LON; smart00464 509170005585 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170005586 Walker A motif; other site 509170005587 ATP binding site [chemical binding]; other site 509170005588 Walker B motif; other site 509170005589 arginine finger; other site 509170005590 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 509170005591 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 509170005592 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 509170005593 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 509170005594 putative active site [active] 509170005595 metal binding site [ion binding]; metal-binding site 509170005596 META domain; Region: META; pfam03724 509170005597 META domain; Region: META; pfam03724 509170005598 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 509170005599 glutamate dehydrogenase; Provisional; Region: PRK09414 509170005600 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 509170005601 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 509170005602 NAD(P) binding site [chemical binding]; other site 509170005603 ferredoxin; Provisional; Region: PRK08764 509170005604 Putative Fe-S cluster; Region: FeS; cl17515 509170005605 4Fe-4S binding domain; Region: Fer4; pfam00037 509170005606 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 509170005607 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 509170005608 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 509170005609 minor groove reading motif; other site 509170005610 helix-hairpin-helix signature motif; other site 509170005611 substrate binding pocket [chemical binding]; other site 509170005612 active site 509170005613 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 509170005614 adenylate kinase; Reviewed; Region: adk; PRK00279 509170005615 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 509170005616 AMP-binding site [chemical binding]; other site 509170005617 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 509170005618 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 509170005619 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 509170005620 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 509170005621 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 509170005622 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509170005623 S-adenosylmethionine binding site [chemical binding]; other site 509170005624 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 509170005625 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 509170005626 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 509170005627 UreF; Region: UreF; pfam01730 509170005628 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 509170005629 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 509170005630 dimer interface [polypeptide binding]; other site 509170005631 catalytic residues [active] 509170005632 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170005633 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005634 urease subunit alpha; Reviewed; Region: ureC; PRK13207 509170005635 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 509170005636 subunit interactions [polypeptide binding]; other site 509170005637 active site 509170005638 flap region; other site 509170005639 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 509170005640 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 509170005641 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 509170005642 gamma-beta subunit interface [polypeptide binding]; other site 509170005643 alpha-beta subunit interface [polypeptide binding]; other site 509170005644 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 509170005645 alpha-gamma subunit interface [polypeptide binding]; other site 509170005646 beta-gamma subunit interface [polypeptide binding]; other site 509170005647 UreD urease accessory protein; Region: UreD; pfam01774 509170005648 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005649 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005650 NlpE N-terminal domain; Region: NlpE; pfam04170 509170005651 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 509170005652 tetramer interface [polypeptide binding]; other site 509170005653 active site 509170005654 Mg2+/Mn2+ binding site [ion binding]; other site 509170005655 isocitrate lyase; Region: PLN02892 509170005656 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509170005657 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509170005658 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 509170005659 substrate binding pocket [chemical binding]; other site 509170005660 dimerization interface [polypeptide binding]; other site 509170005661 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 509170005662 Domain of unknown function DUF21; Region: DUF21; pfam01595 509170005663 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 509170005664 Transporter associated domain; Region: CorC_HlyC; smart01091 509170005665 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005666 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005667 Evidence 7 : Gene remnant; Product type t : transporter; fragment of citrate transporter (partial) 509170005668 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005669 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005670 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170005671 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 509170005672 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 509170005673 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 509170005674 CysD dimerization site [polypeptide binding]; other site 509170005675 G1 box; other site 509170005676 putative GEF interaction site [polypeptide binding]; other site 509170005677 GTP/Mg2+ binding site [chemical binding]; other site 509170005678 Switch I region; other site 509170005679 G2 box; other site 509170005680 G3 box; other site 509170005681 Switch II region; other site 509170005682 G4 box; other site 509170005683 G5 box; other site 509170005684 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 509170005685 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 509170005686 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 509170005687 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 509170005688 Active Sites [active] 509170005689 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 509170005690 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 509170005691 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 509170005692 dimer interface [polypeptide binding]; other site 509170005693 putative anticodon binding site; other site 509170005694 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 509170005695 motif 1; other site 509170005696 active site 509170005697 motif 2; other site 509170005698 motif 3; other site 509170005699 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 509170005700 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 509170005701 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170005702 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170005703 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005704 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 509170005705 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 509170005706 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509170005707 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 509170005708 dimerization interface [polypeptide binding]; other site 509170005709 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 509170005710 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 509170005711 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 509170005712 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 509170005713 Rubredoxin [Energy production and conversion]; Region: COG1773 509170005714 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 509170005715 iron binding site [ion binding]; other site 509170005716 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170005717 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170005718 polyphosphate kinase; Provisional; Region: PRK05443 509170005719 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 509170005720 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 509170005721 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 509170005722 putative active site [active] 509170005723 catalytic site [active] 509170005724 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 509170005725 putative active site [active] 509170005726 putative domain interface [polypeptide binding]; other site 509170005727 catalytic site [active] 509170005728 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 509170005729 Transglycosylase; Region: Transgly; cl17702 509170005730 Rhomboid family; Region: Rhomboid; pfam01694 509170005731 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 3) 509170005732 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170005733 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005734 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170005735 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170005736 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of transport protein (ABC superfamily, atp_bind) (part 2) 509170005737 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of transport protein (ABC superfamily, atp_bind) (part 1) 509170005738 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 509170005739 active site 509170005740 catalytic triad [active] 509170005741 oxyanion hole [active] 509170005742 switch loop; other site 509170005743 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 509170005744 active site clefts [active] 509170005745 zinc binding site [ion binding]; other site 509170005746 dimer interface [polypeptide binding]; other site 509170005747 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 509170005748 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 509170005749 nucleophilic elbow; other site 509170005750 catalytic triad; other site 509170005751 outer membrane receptor FepA; Provisional; Region: PRK13524 509170005752 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509170005753 N-terminal plug; other site 509170005754 ligand-binding site [chemical binding]; other site 509170005755 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 509170005756 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 509170005757 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 509170005758 Rhomboid family; Region: Rhomboid; cl11446 509170005759 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 509170005760 Sulfatase; Region: Sulfatase; pfam00884 509170005761 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170005762 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005763 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005764 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 509170005765 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 509170005766 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170005767 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170005768 Evidence 7 : Gene remnant; Product type m : membrane component; fragment of aerobic C4-dicarboxylate transport protein (partial) 509170005769 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 509170005770 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 509170005771 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 509170005772 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 509170005773 choline transport protein BetT; Provisional; Region: PRK09928 509170005774 BCCT family transporter; Region: BCCT; pfam02028 509170005775 transcriptional regulator BetI; Validated; Region: PRK00767 509170005776 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509170005777 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 509170005778 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 509170005779 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 509170005780 tetrameric interface [polypeptide binding]; other site 509170005781 NAD binding site [chemical binding]; other site 509170005782 catalytic residues [active] 509170005783 choline dehydrogenase; Validated; Region: PRK02106 509170005784 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 509170005785 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005786 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005787 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005788 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005789 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 3) 509170005790 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170005791 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170005792 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005793 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005794 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of site-specific recombinase, integrase from bacteriophage (partial) 509170005795 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 509170005796 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 509170005797 Rifin/stevor family; Region: Rifin_STEVOR; cl14106 509170005798 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 509170005799 active site 509170005800 oxyanion hole [active] 509170005801 catalytic triad [active] 509170005802 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 509170005803 Baseplate J-like protein; Region: Baseplate_J; cl01294 509170005804 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 509170005805 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 509170005806 N-acetyl-D-glucosamine binding site [chemical binding]; other site 509170005807 catalytic residue [active] 509170005808 Protein of unknown function (DUF3277); Region: DUF3277; pfam11681 509170005809 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 509170005810 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 509170005811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834 509170005812 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 509170005813 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 509170005814 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 509170005815 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 509170005816 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 509170005817 large terminase protein; Provisional; Region: 17; PHA02533 509170005818 Phage terminase large subunit; Region: Terminase_3; cl12054 509170005819 Uncharacterized conserved protein (DUF2280); Region: DUF2280; cl02353 509170005820 Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354 509170005821 O-methyltransferase; Region: Methyltransf_2; pfam00891 509170005822 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 509170005823 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442 509170005824 Helix-turn-helix domain; Region: HTH_36; pfam13730 509170005825 fatty acid oxidation complex, alpha subunit, mitochondrial; Region: fa_ox_alpha_mit; TIGR02441 509170005826 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 509170005827 sequence-specific DNA binding site [nucleotide binding]; other site 509170005828 Helix-turn-helix; Region: HTH_3; pfam01381 509170005829 salt bridge; other site 509170005830 Predicted transcriptional regulator [Transcription]; Region: COG2932 509170005831 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 509170005832 Catalytic site [active] 509170005833 KTSC domain; Region: KTSC; pfam13619 509170005834 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 509170005835 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 509170005836 Walker A motif; other site 509170005837 ATP binding site [chemical binding]; other site 509170005838 Walker B motif; other site 509170005839 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 509170005840 integrase; Provisional; Region: PRK09692 509170005841 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 509170005842 active site 509170005843 Int/Topo IB signature motif; other site 509170005844 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 509170005845 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 509170005846 Evidence 7 : Gene remnant; Product type t : transporter; fragment of multidrug resistance transmembrane protein (MFS superfamily) (EmrB) (part 2) 509170005847 Evidence 7 : Gene remnant; Product type t : transporter; fragment of multidrug resistance transmembrane protein (MFS superfamily) (EmrB) (part 1) 509170005848 Evidence 7 : Gene remnant; Product type t : transporter; fragment of multidrug resistance secretion protein (EmrA) 509170005849 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170005850 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005851 Evidence 7 : Gene remnant; Product type t : transporter; fragment of multidrug resistance secretion protein (part 1) 509170005852 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 509170005853 CoenzymeA binding site [chemical binding]; other site 509170005854 subunit interaction site [polypeptide binding]; other site 509170005855 PHB binding site; other site 509170005856 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 509170005857 dimer interface [polypeptide binding]; other site 509170005858 allosteric magnesium binding site [ion binding]; other site 509170005859 active site 509170005860 aspartate-rich active site metal binding site; other site 509170005861 Schiff base residues; other site 509170005862 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 509170005863 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 509170005864 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 509170005865 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170005866 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 509170005867 NAD(P) binding site [chemical binding]; other site 509170005868 active site 509170005869 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 509170005870 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 509170005871 OsmC-like protein; Region: OsmC; cl00767 509170005872 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 509170005873 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 509170005874 active site 509170005875 metal binding site [ion binding]; metal-binding site 509170005876 DNA binding site [nucleotide binding] 509170005877 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 509170005878 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 509170005879 Walker A/P-loop; other site 509170005880 ATP binding site [chemical binding]; other site 509170005881 Q-loop/lid; other site 509170005882 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 509170005883 ABC transporter signature motif; other site 509170005884 Walker B; other site 509170005885 D-loop; other site 509170005886 H-loop/switch region; other site 509170005887 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 509170005888 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 509170005889 catalytic residue [active] 509170005890 Evidence 7 : Gene remnant; Product type ph : phenotype; fragment of twitching motility protein (part 1) 509170005891 Evidence 7 : Gene remnant; Product type ph : phenotype; fragment of twitching motility protein (part 2) 509170005892 Evidence 7 : Gene remnant; Product type ph : phenotype; fragment of twitching motility protein (part 1) 509170005893 Evidence 7 : Gene remnant; Product type ph : phenotype; fragment of twitching motility protein (part 2) 509170005894 ferric uptake regulator; Provisional; Region: fur; PRK09462 509170005895 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 509170005896 metal binding site 2 [ion binding]; metal-binding site 509170005897 putative DNA binding helix; other site 509170005898 metal binding site 1 [ion binding]; metal-binding site 509170005899 dimer interface [polypeptide binding]; other site 509170005900 structural Zn2+ binding site [ion binding]; other site 509170005901 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 509170005902 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 509170005903 hypothetical protein; Validated; Region: PRK01777 509170005904 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 509170005905 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 509170005906 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170005907 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170005908 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170005909 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005910 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005911 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005912 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 509170005913 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 509170005914 putative active site [active] 509170005915 putative dimer interface [polypeptide binding]; other site 509170005916 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 509170005917 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 509170005918 feedback inhibition sensing region; other site 509170005919 homohexameric interface [polypeptide binding]; other site 509170005920 nucleotide binding site [chemical binding]; other site 509170005921 N-acetyl-L-glutamate binding site [chemical binding]; other site 509170005922 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 509170005923 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 509170005924 active site 509170005925 substrate binding site [chemical binding]; other site 509170005926 metal binding site [ion binding]; metal-binding site 509170005927 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 509170005928 trimer interface [polypeptide binding]; other site 509170005929 active site 509170005930 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 509170005931 Part of AAA domain; Region: AAA_19; pfam13245 509170005932 Family description; Region: UvrD_C_2; pfam13538 509170005933 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 509170005934 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 509170005935 ligand binding site [chemical binding]; other site 509170005936 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 509170005937 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 509170005938 putative acyl-acceptor binding pocket; other site 509170005939 Septum formation inhibitor [Cell division and chromosome partitioning]; Region: MinC; COG0850 509170005940 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 509170005941 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 509170005942 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 509170005943 Switch I; other site 509170005944 Switch II; other site 509170005945 Septum formation topological specificity factor MinE; Region: MinE; pfam03776 509170005946 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170005947 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005948 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 509170005949 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 509170005950 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 509170005951 thioredoxin reductase; Provisional; Region: PRK10262 509170005952 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 509170005953 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 509170005954 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 509170005955 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 509170005956 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 509170005957 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 509170005958 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 509170005959 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 509170005960 Coenzyme A binding pocket [chemical binding]; other site 509170005961 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 509170005962 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 509170005963 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 509170005964 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 509170005965 elongation factor Tu; Reviewed; Region: PRK00049 509170005966 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 509170005967 G1 box; other site 509170005968 GEF interaction site [polypeptide binding]; other site 509170005969 GTP/Mg2+ binding site [chemical binding]; other site 509170005970 Switch I region; other site 509170005971 G2 box; other site 509170005972 G3 box; other site 509170005973 Switch II region; other site 509170005974 G4 box; other site 509170005975 G5 box; other site 509170005976 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 509170005977 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 509170005978 Antibiotic Binding Site [chemical binding]; other site 509170005979 elongation factor G; Reviewed; Region: PRK00007 509170005980 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 509170005981 G1 box; other site 509170005982 putative GEF interaction site [polypeptide binding]; other site 509170005983 GTP/Mg2+ binding site [chemical binding]; other site 509170005984 Switch I region; other site 509170005985 G2 box; other site 509170005986 G3 box; other site 509170005987 Switch II region; other site 509170005988 G4 box; other site 509170005989 G5 box; other site 509170005990 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 509170005991 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 509170005992 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 509170005993 30S ribosomal protein S7; Validated; Region: PRK05302 509170005994 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 509170005995 S17 interaction site [polypeptide binding]; other site 509170005996 S8 interaction site; other site 509170005997 16S rRNA interaction site [nucleotide binding]; other site 509170005998 streptomycin interaction site [chemical binding]; other site 509170005999 23S rRNA interaction site [nucleotide binding]; other site 509170006000 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 509170006001 EcsC protein family; Region: EcsC; pfam12787 509170006002 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 509170006003 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 509170006004 dimer interface [polypeptide binding]; other site 509170006005 active site 509170006006 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 509170006007 Pirin; Region: Pirin; pfam02678 509170006008 Pirin-related protein [General function prediction only]; Region: COG1741 509170006009 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 509170006010 NAD synthetase; Provisional; Region: PRK13981 509170006011 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 509170006012 multimer interface [polypeptide binding]; other site 509170006013 active site 509170006014 catalytic triad [active] 509170006015 protein interface 1 [polypeptide binding]; other site 509170006016 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 509170006017 homodimer interface [polypeptide binding]; other site 509170006018 NAD binding pocket [chemical binding]; other site 509170006019 ATP binding pocket [chemical binding]; other site 509170006020 Mg binding site [ion binding]; other site 509170006021 active-site loop [active] 509170006022 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 509170006023 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 509170006024 FMN-binding pocket [chemical binding]; other site 509170006025 flavin binding motif; other site 509170006026 phosphate binding motif [ion binding]; other site 509170006027 beta-alpha-beta structure motif; other site 509170006028 NAD binding pocket [chemical binding]; other site 509170006029 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 509170006030 catalytic loop [active] 509170006031 iron binding site [ion binding]; other site 509170006032 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of Succinate-semialdehyde dehydrogenase [NADP+] (SSDH) (partial) 509170006033 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170006034 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006035 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 509170006036 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 509170006037 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 509170006038 active site 509170006039 (T/H)XGH motif; other site 509170006040 integrase; Provisional; Region: PRK09692 509170006041 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 509170006042 active site 509170006043 Int/Topo IB signature motif; other site 509170006044 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of lysozyme from bacteriophage 509170006045 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170006046 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170006047 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006048 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170006049 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 509170006050 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170006051 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006052 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 509170006053 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 509170006054 sequence-specific DNA binding site [nucleotide binding]; other site 509170006055 salt bridge; other site 509170006056 Predicted transcriptional regulator [Transcription]; Region: COG2932 509170006057 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 509170006058 Catalytic site [active] 509170006059 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170006060 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170006061 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006062 replicative DNA helicase; Provisional; Region: PRK08840 509170006063 ERF superfamily; Region: ERF; pfam04404 509170006064 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein; phage-related protein (part 1) 509170006065 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170006066 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170006067 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein; phage-related protein (part 2) 509170006068 BRO family, N-terminal domain; Region: Bro-N; smart01040 509170006069 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 509170006070 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 509170006071 SmpB-tmRNA interface; other site 509170006072 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 509170006073 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 509170006074 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 509170006075 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 509170006076 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 509170006077 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 509170006078 RNA binding surface [nucleotide binding]; other site 509170006079 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 509170006080 active site 509170006081 Outer membrane lipoprotein; Region: YfiO; pfam13525 509170006082 DNA primase; Validated; Region: dnaG; PRK05667 509170006083 CHC2 zinc finger; Region: zf-CHC2; pfam01807 509170006084 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 509170006085 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 509170006086 active site 509170006087 metal binding site [ion binding]; metal-binding site 509170006088 interdomain interaction site; other site 509170006089 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 509170006090 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 509170006091 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 509170006092 tRNA; other site 509170006093 putative tRNA binding site [nucleotide binding]; other site 509170006094 putative NADP binding site [chemical binding]; other site 509170006095 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 509170006096 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 509170006097 binding surface 509170006098 TPR motif; other site 509170006099 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 509170006100 binding surface 509170006101 TPR motif; other site 509170006102 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 509170006103 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 509170006104 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 509170006105 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 509170006106 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 509170006107 active site 509170006108 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 509170006109 5S rRNA interface [nucleotide binding]; other site 509170006110 CTC domain interface [polypeptide binding]; other site 509170006111 L16 interface [polypeptide binding]; other site 509170006112 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 509170006113 putative active site [active] 509170006114 catalytic residue [active] 509170006115 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 509170006116 tetramerization interface [polypeptide binding]; other site 509170006117 active site 509170006118 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170006119 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170006120 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006121 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170006122 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170006123 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 509170006124 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 509170006125 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 509170006126 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 509170006127 motif II; other site 509170006128 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 509170006129 dimer interface [polypeptide binding]; other site 509170006130 substrate binding site [chemical binding]; other site 509170006131 ATP binding site [chemical binding]; other site 509170006132 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 509170006133 BON domain; Region: BON; pfam04972 509170006134 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 509170006135 acyl carrier protein; Provisional; Region: acpP; PRK00982 509170006136 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 509170006137 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 509170006138 NAD(P) binding site [chemical binding]; other site 509170006139 homotetramer interface [polypeptide binding]; other site 509170006140 homodimer interface [polypeptide binding]; other site 509170006141 active site 509170006142 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 509170006143 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 509170006144 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 509170006145 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 509170006146 Protein of unknown function, DUF462; Region: DUF462; pfam04315 509170006147 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170006148 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006149 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 509170006150 ScpA/B protein; Region: ScpA_ScpB; cl00598 509170006151 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 509170006152 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 509170006153 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 509170006154 RNA binding surface [nucleotide binding]; other site 509170006155 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 509170006156 probable active site [active] 509170006157 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 509170006158 AAA domain; Region: AAA_26; pfam13500 509170006159 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 509170006160 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509170006161 S-adenosylmethionine binding site [chemical binding]; other site 509170006162 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 509170006163 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 509170006164 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 509170006165 catalytic residue [active] 509170006166 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 509170006167 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 509170006168 inhibitor-cofactor binding pocket; inhibition site 509170006169 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170006170 catalytic residue [active] 509170006171 carboxylesterase BioH; Provisional; Region: PRK10349 509170006172 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 509170006173 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 509170006174 active site 509170006175 motif I; other site 509170006176 motif II; other site 509170006177 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 509170006178 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 509170006179 active site 509170006180 homotetramer interface [polypeptide binding]; other site 509170006181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170006182 Major Facilitator Superfamily; Region: MFS_1; pfam07690 509170006183 putative substrate translocation pore; other site 509170006184 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 509170006185 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 509170006186 heme binding site [chemical binding]; other site 509170006187 ferroxidase pore; other site 509170006188 ferroxidase diiron center [ion binding]; other site 509170006189 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 509170006190 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 509170006191 nucleotide binding pocket [chemical binding]; other site 509170006192 K-X-D-G motif; other site 509170006193 catalytic site [active] 509170006194 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 509170006195 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 509170006196 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 509170006197 Dimer interface [polypeptide binding]; other site 509170006198 BRCT sequence motif; other site 509170006199 ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354 509170006200 FtsZ protein binding site [polypeptide binding]; other site 509170006201 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 509170006202 AAA domain; Region: AAA_23; pfam13476 509170006203 Walker A/P-loop; other site 509170006204 ATP binding site [chemical binding]; other site 509170006205 Q-loop/lid; other site 509170006206 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 509170006207 ABC transporter signature motif; other site 509170006208 Walker B; other site 509170006209 D-loop; other site 509170006210 H-loop/switch region; other site 509170006211 Transcriptional regulators [Transcription]; Region: GntR; COG1802 509170006212 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509170006213 DNA-binding site [nucleotide binding]; DNA binding site 509170006214 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 509170006215 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 509170006216 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 509170006217 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 509170006218 pantothenate kinase; Reviewed; Region: PRK13322 509170006219 signal recognition particle protein; Provisional; Region: PRK10867 509170006220 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 509170006221 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 509170006222 GTP binding site [chemical binding]; other site 509170006223 Signal peptide binding domain; Region: SRP_SPB; pfam02978 509170006224 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 509170006225 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 509170006226 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 509170006227 FMN binding site [chemical binding]; other site 509170006228 active site 509170006229 catalytic residues [active] 509170006230 substrate binding site [chemical binding]; other site 509170006231 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170006232 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006233 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170006234 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170006235 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006236 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 509170006237 trimer interface [polypeptide binding]; other site 509170006238 active site 509170006239 Evidence 7 : Gene remnant; Product type pm : membrane component; fragment of threonine efflux protein (partial) 509170006240 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170006241 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170006242 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 509170006243 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 509170006244 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 509170006245 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 509170006246 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 509170006247 active site 509170006248 HIGH motif; other site 509170006249 KMSKS motif; other site 509170006250 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 509170006251 tRNA binding surface [nucleotide binding]; other site 509170006252 anticodon binding site; other site 509170006253 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 509170006254 dimer interface [polypeptide binding]; other site 509170006255 putative tRNA-binding site [nucleotide binding]; other site 509170006256 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 509170006257 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509170006258 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509170006259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170006260 Major Facilitator Superfamily; Region: MFS_1; pfam07690 509170006261 putative substrate translocation pore; other site 509170006262 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 509170006263 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 509170006264 HlyD family secretion protein; Region: HlyD_3; pfam13437 509170006265 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 509170006266 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 509170006267 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 509170006268 catalytic residue [active] 509170006269 HI0933-like protein; Region: HI0933_like; pfam03486 509170006270 Conserved TM helix; Region: TM_helix; pfam05552 509170006271 Conserved TM helix; Region: TM_helix; pfam05552 509170006272 Conserved TM helix; Region: TM_helix; pfam05552 509170006273 Conserved TM helix; Region: TM_helix; pfam05552 509170006274 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170006275 ferredoxin-NADP reductase; Provisional; Region: PRK10926 509170006276 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 509170006277 FAD binding pocket [chemical binding]; other site 509170006278 FAD binding motif [chemical binding]; other site 509170006279 phosphate binding motif [ion binding]; other site 509170006280 beta-alpha-beta structure motif; other site 509170006281 NAD binding pocket [chemical binding]; other site 509170006282 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 509170006283 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509170006284 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 509170006285 putative dimerization interface [polypeptide binding]; other site 509170006286 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 509170006287 DNA-binding site [nucleotide binding]; DNA binding site 509170006288 RNA-binding motif; other site 509170006289 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 509170006290 active site 509170006291 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 509170006292 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 509170006293 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 509170006294 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 509170006295 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 509170006296 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 509170006297 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 509170006298 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 509170006299 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 509170006300 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 509170006301 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 509170006302 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 509170006303 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 509170006304 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 509170006305 NADH dehydrogenase subunit G; Validated; Region: PRK08166 509170006306 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 509170006307 catalytic loop [active] 509170006308 iron binding site [ion binding]; other site 509170006309 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 509170006310 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 509170006311 [4Fe-4S] binding site [ion binding]; other site 509170006312 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 509170006313 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 509170006314 SLBB domain; Region: SLBB; pfam10531 509170006315 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 509170006316 NADH dehydrogenase subunit E; Validated; Region: PRK07539 509170006317 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 509170006318 putative dimer interface [polypeptide binding]; other site 509170006319 [2Fe-2S] cluster binding site [ion binding]; other site 509170006320 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 509170006321 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 509170006322 NADH dehydrogenase subunit D; Validated; Region: PRK06075 509170006323 NADH dehydrogenase subunit B; Validated; Region: PRK06411 509170006324 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 509170006325 Evidence 7 : Gene remnant; Product type pm : membrane component; fragment of membrane protein; GGDEF domain (part 1) 509170006326 Evidence 7 : Gene remnant; Product type pm : membrane component; fragment of membrane protein; GGDEF domain (part 2) 509170006327 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 509170006328 dimerization interface [polypeptide binding]; other site 509170006329 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509170006330 dimer interface [polypeptide binding]; other site 509170006331 phosphorylation site [posttranslational modification] 509170006332 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509170006333 ATP binding site [chemical binding]; other site 509170006334 Mg2+ binding site [ion binding]; other site 509170006335 G-X-G motif; other site 509170006336 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 509170006337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509170006338 active site 509170006339 phosphorylation site [posttranslational modification] 509170006340 intermolecular recognition site; other site 509170006341 dimerization interface [polypeptide binding]; other site 509170006342 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 509170006343 DNA binding site [nucleotide binding] 509170006344 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 509170006345 ATP cone domain; Region: ATP-cone; pfam03477 509170006346 Class I ribonucleotide reductase; Region: RNR_I; cd01679 509170006347 active site 509170006348 dimer interface [polypeptide binding]; other site 509170006349 catalytic residues [active] 509170006350 effector binding site; other site 509170006351 R2 peptide binding site; other site 509170006352 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 509170006353 dimer interface [polypeptide binding]; other site 509170006354 putative radical transfer pathway; other site 509170006355 diiron center [ion binding]; other site 509170006356 tyrosyl radical; other site 509170006357 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170006358 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006359 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170006360 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170006361 Flavin Reductases; Region: FlaRed; cl00801 509170006362 methionine synthase; Provisional; Region: PRK01207 509170006363 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 509170006364 substrate binding site [chemical binding]; other site 509170006365 THF binding site; other site 509170006366 zinc-binding site [ion binding]; other site 509170006367 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 509170006368 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 509170006369 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509170006370 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509170006371 dimerization interface [polypeptide binding]; other site 509170006372 LysE type translocator; Region: LysE; cl00565 509170006373 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509170006374 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 509170006375 putative dimerization interface [polypeptide binding]; other site 509170006376 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170006377 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006378 citrate-proton symporter; Provisional; Region: PRK15075 509170006379 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170006380 putative substrate translocation pore; other site 509170006381 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of substrate-binding protein (ABC superfamily, peri-bind) (part 1) 509170006382 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of substrate-binding protein (ABC superfamily, peri-bind) (part 2) 509170006383 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of transcriptional regulator (LysR family) (partial) 509170006384 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170006385 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006386 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of citrate utilization protein B (partial) 509170006387 HPP family; Region: HPP; pfam04982 509170006388 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509170006389 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509170006390 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 509170006391 nitrobindin heme-binding domain; Region: nitrobindin; cl10502 509170006392 CoA-transferase family III; Region: CoA_transf_3; pfam02515 509170006393 benzoate transport; Region: 2A0115; TIGR00895 509170006394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170006395 putative substrate translocation pore; other site 509170006396 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 509170006397 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 509170006398 FAD binding site [chemical binding]; other site 509170006399 substrate binding pocket [chemical binding]; other site 509170006400 catalytic base [active] 509170006401 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 509170006402 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509170006403 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509170006404 dimerization interface [polypeptide binding]; other site 509170006405 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of Zinc-binding dehydrogenase (part 2) 509170006406 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of Zinc-binding dehydrogenase (part 1) 509170006407 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 509170006408 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 509170006409 active site 509170006410 purine riboside binding site [chemical binding]; other site 509170006411 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 509170006412 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 509170006413 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 509170006414 active site 509170006415 DNA binding site [nucleotide binding] 509170006416 Int/Topo IB signature motif; other site 509170006417 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170006418 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006419 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 509170006420 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 509170006421 dimer interface [polypeptide binding]; other site 509170006422 ssDNA binding site [nucleotide binding]; other site 509170006423 tetramer (dimer of dimers) interface [polypeptide binding]; other site 509170006424 Domain of unknown function (DUF3127); Region: DUF3127; pfam11325 509170006425 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170006426 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170006427 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 509170006428 active site 509170006429 metal binding site [ion binding]; metal-binding site 509170006430 interdomain interaction site; other site 509170006431 Helix-turn-helix domain; Region: HTH_18; pfam12833 509170006432 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170006433 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170006434 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006435 PAAR motif; Region: PAAR_motif; pfam05488 509170006436 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; fragment of phage-related DNA adenine methylase (part 1) 509170006437 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; fragment of phage-related DNA adenine methylase (part 2) 509170006438 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 509170006439 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 509170006440 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 509170006441 LysE type translocator; Region: LysE; cl00565 509170006442 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 509170006443 Phage tail tube protein FII; Region: Phage_tube; cl01390 509170006444 major tail sheath protein; Provisional; Region: FI; PHA02560 509170006445 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 509170006446 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 509170006447 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684 509170006448 Baseplate J-like protein; Region: Baseplate_J; cl01294 509170006449 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 509170006450 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 509170006451 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 509170006452 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 509170006453 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 509170006454 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 509170006455 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 509170006456 Protein of unknown function (DUF754); Region: DUF754; pfam05449 509170006457 Phage Tail Protein X; Region: Phage_tail_X; cl02088 509170006458 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 509170006459 terminase endonuclease subunit; Provisional; Region: M; PHA02537 509170006460 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 509170006461 capsid protein; Provisional; Region: N; PHA02538 509170006462 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 509170006463 terminase ATPase subunit; Provisional; Region: P; PHA02535 509170006464 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 509170006465 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 509170006466 Phage-related protein [Function unknown]; Region: COG4695; cl01923 509170006467 Phage portal protein; Region: Phage_portal; pfam04860 509170006468 YcfA-like protein; Region: YcfA; pfam07927 509170006469 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 509170006470 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170006471 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006472 quinolinate synthetase; Provisional; Region: PRK09375 509170006473 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 509170006474 heterotetramer interface [polypeptide binding]; other site 509170006475 active site pocket [active] 509170006476 cleavage site 509170006477 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 509170006478 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 509170006479 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 509170006480 DNA binding site [nucleotide binding] 509170006481 active site 509170006482 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 509170006483 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 509170006484 Evidence 7 : Gene remnant; Product type ph : phenotype; fragment of copper resistance protein B precursor (partial) 509170006485 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170006486 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006487 Evidence 7 : Gene remnant; Product type ph : phenotype; fragment of copper resistance protein A precursor (partial) 509170006488 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 509170006489 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 509170006490 active site 509170006491 motif I; other site 509170006492 motif II; other site 509170006493 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 509170006494 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 509170006495 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 509170006496 substrate binding site [chemical binding]; other site 509170006497 hexamer interface [polypeptide binding]; other site 509170006498 metal binding site [ion binding]; metal-binding site 509170006499 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981 509170006500 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of esterase (part 2) 509170006501 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of esterase (part 1) 509170006502 Peptidase C13 family; Region: Peptidase_C13; pfam01650 509170006503 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 509170006504 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 509170006505 Glycoprotease family; Region: Peptidase_M22; pfam00814 509170006506 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 509170006507 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 509170006508 trimer interface [polypeptide binding]; other site 509170006509 putative metal binding site [ion binding]; other site 509170006510 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 509170006511 putative active site [active] 509170006512 putative CoA binding site [chemical binding]; other site 509170006513 nudix motif; other site 509170006514 metal binding site [ion binding]; metal-binding site 509170006515 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 509170006516 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 509170006517 nudix motif; other site 509170006518 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170006519 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170006520 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006521 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170006522 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 509170006523 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK11907 509170006524 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 509170006525 putative active site [active] 509170006526 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170006527 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006528 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 509170006529 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 509170006530 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 509170006531 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 509170006532 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 509170006533 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170006534 homodimer interface [polypeptide binding]; other site 509170006535 catalytic residue [active] 509170006536 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 509170006537 histidinol dehydrogenase; Region: hisD; TIGR00069 509170006538 NAD binding site [chemical binding]; other site 509170006539 dimerization interface [polypeptide binding]; other site 509170006540 product binding site; other site 509170006541 substrate binding site [chemical binding]; other site 509170006542 zinc binding site [ion binding]; other site 509170006543 catalytic residues [active] 509170006544 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 509170006545 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 509170006546 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 509170006547 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 509170006548 hinge; other site 509170006549 active site 509170006550 BolA-like protein; Region: BolA; cl00386 509170006551 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 509170006552 30S subunit binding site; other site 509170006553 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 509170006554 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 509170006555 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 509170006556 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 509170006557 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170006558 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170006559 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006560 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170006561 Evidence 7 : Gene remnant; Product type pm : membrane component; fragment of lipoprotein precursor (partial) 509170006562 phosphodiesterase YaeI; Provisional; Region: PRK11340 509170006563 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 509170006564 putative active site [active] 509170006565 putative metal binding site [ion binding]; other site 509170006566 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 509170006567 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 509170006568 putative active site [active] 509170006569 catalytic site [active] 509170006570 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 509170006571 putative active site [active] 509170006572 catalytic site [active] 509170006573 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 509170006574 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 509170006575 putative acyl-acceptor binding pocket; other site 509170006576 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 509170006577 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 509170006578 HflX GTPase family; Region: HflX; cd01878 509170006579 G1 box; other site 509170006580 GTP/Mg2+ binding site [chemical binding]; other site 509170006581 Switch I region; other site 509170006582 G2 box; other site 509170006583 G3 box; other site 509170006584 Switch II region; other site 509170006585 G4 box; other site 509170006586 G5 box; other site 509170006587 LrgB-like family; Region: LrgB; cl00596 509170006588 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 509170006589 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 509170006590 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 509170006591 active site 509170006592 metal binding site [ion binding]; metal-binding site 509170006593 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 509170006594 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 509170006595 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 509170006596 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 509170006597 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 509170006598 23S rRNA interface [nucleotide binding]; other site 509170006599 L3 interface [polypeptide binding]; other site 509170006600 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 509170006601 stringent starvation protein A; Provisional; Region: sspA; PRK09481 509170006602 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 509170006603 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 509170006604 dimer interface [polypeptide binding]; other site 509170006605 N-terminal domain interface [polypeptide binding]; other site 509170006606 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 509170006607 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 509170006608 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 509170006609 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 509170006610 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 509170006611 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 509170006612 carboxyltransferase (CT) interaction site; other site 509170006613 biotinylation site [posttranslational modification]; other site 509170006614 enoyl-CoA hydratase; Provisional; Region: PRK05995 509170006615 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 509170006616 substrate binding site [chemical binding]; other site 509170006617 oxyanion hole (OAH) forming residues; other site 509170006618 trimer interface [polypeptide binding]; other site 509170006619 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 509170006620 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509170006621 active site 509170006622 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 509170006623 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 509170006624 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 509170006625 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 509170006626 NAD(P) binding site [chemical binding]; other site 509170006627 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 509170006628 substrate binding site [chemical binding]; other site 509170006629 homotetramer interface [polypeptide binding]; other site 509170006630 active site 509170006631 homodimer interface [polypeptide binding]; other site 509170006632 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 509170006633 RUN domain; Region: RUN; cl02689 509170006634 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509170006635 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509170006636 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 509170006637 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509170006638 active site 509170006639 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 509170006640 Uncharacterized conserved protein [Function unknown]; Region: COG3791 509170006641 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170006642 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006643 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170006644 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170006645 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 509170006646 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 509170006647 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 509170006648 VacJ like lipoprotein; Region: VacJ; cl01073 509170006649 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 509170006650 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 509170006651 anti sigma factor interaction site; other site 509170006652 regulatory phosphorylation site [posttranslational modification]; other site 509170006653 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 509170006654 nitrilase; Region: PLN02798 509170006655 putative active site [active] 509170006656 catalytic triad [active] 509170006657 dimer interface [polypeptide binding]; other site 509170006658 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 509170006659 MarR family; Region: MarR; pfam01047 509170006660 Evidence 7 : Gene remnant; Product type ph : phenotype; fragment of organic hydroperoxide resistance protein (part 1) 509170006661 Evidence 7 : Gene remnant; Product type ph : phenotype; fragment of organic hydroperoxide resistance protein (part 2) 509170006662 type II secretion system protein E; Region: type_II_gspE; TIGR02533 509170006663 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 509170006664 Walker A motif; other site 509170006665 ATP binding site [chemical binding]; other site 509170006666 Walker B motif; other site 509170006667 Protein of unknown function (DUF432); Region: DUF432; cl01027 509170006668 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 509170006669 Mechanosensitive ion channel; Region: MS_channel; pfam00924 509170006670 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 509170006671 DNA polymerase I; Provisional; Region: PRK05755 509170006672 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 509170006673 active site 509170006674 metal binding site 1 [ion binding]; metal-binding site 509170006675 putative 5' ssDNA interaction site; other site 509170006676 metal binding site 3; metal-binding site 509170006677 metal binding site 2 [ion binding]; metal-binding site 509170006678 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 509170006679 putative DNA binding site [nucleotide binding]; other site 509170006680 putative metal binding site [ion binding]; other site 509170006681 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 509170006682 active site 509170006683 catalytic site [active] 509170006684 substrate binding site [chemical binding]; other site 509170006685 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 509170006686 active site 509170006687 DNA binding site [nucleotide binding] 509170006688 catalytic site [active] 509170006689 YGGT family; Region: YGGT; pfam02325 509170006690 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 509170006691 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 509170006692 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 509170006693 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 509170006694 Ligand Binding Site [chemical binding]; other site 509170006695 TilS substrate binding domain; Region: TilS; pfam09179 509170006696 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 509170006697 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 509170006698 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 509170006699 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 509170006700 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 509170006701 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 509170006702 catalytic residues [active] 509170006703 transcription termination factor Rho; Provisional; Region: rho; PRK09376 509170006704 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 509170006705 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 509170006706 RNA binding site [nucleotide binding]; other site 509170006707 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 509170006708 multimer interface [polypeptide binding]; other site 509170006709 Walker A motif; other site 509170006710 ATP binding site [chemical binding]; other site 509170006711 Walker B motif; other site 509170006712 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 509170006713 IHF dimer interface [polypeptide binding]; other site 509170006714 IHF - DNA interface [nucleotide binding]; other site 509170006715 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 509170006716 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 509170006717 putative tRNA-binding site [nucleotide binding]; other site 509170006718 B3/4 domain; Region: B3_4; pfam03483 509170006719 tRNA synthetase B5 domain; Region: B5; smart00874 509170006720 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 509170006721 dimer interface [polypeptide binding]; other site 509170006722 motif 1; other site 509170006723 motif 3; other site 509170006724 motif 2; other site 509170006725 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 509170006726 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 509170006727 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 509170006728 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 509170006729 dimer interface [polypeptide binding]; other site 509170006730 motif 1; other site 509170006731 active site 509170006732 motif 2; other site 509170006733 motif 3; other site 509170006734 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170006735 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170006736 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006737 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170006738 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 509170006739 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 509170006740 Coenzyme A binding pocket [chemical binding]; other site 509170006741 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 509170006742 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 509170006743 23S rRNA binding site [nucleotide binding]; other site 509170006744 L21 binding site [polypeptide binding]; other site 509170006745 L13 binding site [polypeptide binding]; other site 509170006746 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 509170006747 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of transporter (part 1) 509170006748 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170006749 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006750 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of transporter (part 2) 509170006751 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of transporter (part 3) 509170006752 Predicted membrane protein [Function unknown]; Region: COG1238 509170006753 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 509170006754 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 509170006755 C-terminal domain interface [polypeptide binding]; other site 509170006756 GSH binding site (G-site) [chemical binding]; other site 509170006757 dimer interface [polypeptide binding]; other site 509170006758 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 509170006759 N-terminal domain interface [polypeptide binding]; other site 509170006760 putative dimer interface [polypeptide binding]; other site 509170006761 active site 509170006762 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 509170006763 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 509170006764 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 509170006765 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 509170006766 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 509170006767 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 509170006768 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 509170006769 active site 509170006770 dimer interface [polypeptide binding]; other site 509170006771 motif 1; other site 509170006772 motif 2; other site 509170006773 motif 3; other site 509170006774 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 509170006775 anticodon binding site; other site 509170006776 acyl-CoA synthetase; Validated; Region: PRK08162 509170006777 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 509170006778 acyl-activating enzyme (AAE) consensus motif; other site 509170006779 putative active site [active] 509170006780 AMP binding site [chemical binding]; other site 509170006781 putative CoA binding site [chemical binding]; other site 509170006782 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170006783 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170006784 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170006785 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170006786 hypothetical protein; Provisional; Region: PRK05255 509170006787 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 509170006788 dimerization domain swap beta strand [polypeptide binding]; other site 509170006789 regulatory protein interface [polypeptide binding]; other site 509170006790 active site 509170006791 regulatory phosphorylation site [posttranslational modification]; other site 509170006792 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 509170006793 pantoate--beta-alanine ligase; Region: panC; TIGR00018 509170006794 Pantoate-beta-alanine ligase; Region: PanC; cd00560 509170006795 active site 509170006796 ATP-binding site [chemical binding]; other site 509170006797 pantoate-binding site; other site 509170006798 HXXH motif; other site 509170006799 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 509170006800 oligomerization interface [polypeptide binding]; other site 509170006801 active site 509170006802 metal binding site [ion binding]; metal-binding site 509170006803 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 509170006804 catalytic center binding site [active] 509170006805 ATP binding site [chemical binding]; other site 509170006806 poly(A) polymerase; Region: pcnB; TIGR01942 509170006807 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 509170006808 active site 509170006809 NTP binding site [chemical binding]; other site 509170006810 metal binding triad [ion binding]; metal-binding site 509170006811 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 509170006812 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 509170006813 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 509170006814 Helix-hairpin-helix motif; Region: HHH; pfam00633 509170006815 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 509170006816 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 509170006817 homodimer interface [polypeptide binding]; other site 509170006818 metal binding site [ion binding]; metal-binding site 509170006819 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 509170006820 homodimer interface [polypeptide binding]; other site 509170006821 active site 509170006822 putative chemical substrate binding site [chemical binding]; other site 509170006823 metal binding site [ion binding]; metal-binding site 509170006824 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170006825 short chain dehydrogenase; Validated; Region: PRK07069 509170006826 NAD(P) binding site [chemical binding]; other site 509170006827 active site 509170006828 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170006829 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170006830 HD domain; Region: HD_4; pfam13328 509170006831 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 509170006832 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 509170006833 synthetase active site [active] 509170006834 NTP binding site [chemical binding]; other site 509170006835 metal binding site [ion binding]; metal-binding site 509170006836 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 509170006837 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 509170006838 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 509170006839 TRAM domain; Region: TRAM; pfam01938 509170006840 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509170006841 S-adenosylmethionine binding site [chemical binding]; other site 509170006842 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 509170006843 active site 509170006844 catalytic site [active] 509170006845 substrate binding site [chemical binding]; other site 509170006846 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 509170006847 cysteine synthase B; Region: cysM; TIGR01138 509170006848 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 509170006849 dimer interface [polypeptide binding]; other site 509170006850 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170006851 catalytic residue [active] 509170006852 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509170006853 dimer interface [polypeptide binding]; other site 509170006854 phosphorylation site [posttranslational modification] 509170006855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509170006856 ATP binding site [chemical binding]; other site 509170006857 Mg2+ binding site [ion binding]; other site 509170006858 G-X-G motif; other site 509170006859 Response regulator receiver domain; Region: Response_reg; pfam00072 509170006860 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509170006861 active site 509170006862 phosphorylation site [posttranslational modification] 509170006863 intermolecular recognition site; other site 509170006864 dimerization interface [polypeptide binding]; other site 509170006865 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 509170006866 enoyl-CoA hydratase; Provisional; Region: PRK07509 509170006867 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 509170006868 substrate binding site [chemical binding]; other site 509170006869 oxyanion hole (OAH) forming residues; other site 509170006870 trimer interface [polypeptide binding]; other site 509170006871 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 509170006872 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 509170006873 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 509170006874 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 509170006875 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170006876 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006877 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 509170006878 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 509170006879 putative NAD(P) binding site [chemical binding]; other site 509170006880 active site 509170006881 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 509170006882 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 509170006883 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 509170006884 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 509170006885 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 509170006886 ligand binding site [chemical binding]; other site 509170006887 homodimer interface [polypeptide binding]; other site 509170006888 NAD(P) binding site [chemical binding]; other site 509170006889 trimer interface B [polypeptide binding]; other site 509170006890 trimer interface A [polypeptide binding]; other site 509170006891 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 509170006892 EamA-like transporter family; Region: EamA; pfam00892 509170006893 EamA-like transporter family; Region: EamA; pfam00892 509170006894 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 509170006895 homotrimer interaction site [polypeptide binding]; other site 509170006896 putative active site [active] 509170006897 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 509170006898 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170006899 putative substrate translocation pore; other site 509170006900 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 509170006901 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 509170006902 FMN binding site [chemical binding]; other site 509170006903 active site 509170006904 catalytic residues [active] 509170006905 substrate binding site [chemical binding]; other site 509170006906 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509170006907 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509170006908 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 509170006909 dimerization interface [polypeptide binding]; other site 509170006910 substrate binding pocket [chemical binding]; other site 509170006911 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 509170006912 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 509170006913 putative ATP binding site [chemical binding]; other site 509170006914 putative substrate interface [chemical binding]; other site 509170006915 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 509170006916 homotrimer interaction site [polypeptide binding]; other site 509170006917 putative active site [active] 509170006918 aconitate hydratase; Validated; Region: PRK09277 509170006919 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 509170006920 substrate binding site [chemical binding]; other site 509170006921 ligand binding site [chemical binding]; other site 509170006922 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 509170006923 substrate binding site [chemical binding]; other site 509170006924 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 509170006925 active site 509170006926 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 509170006927 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 509170006928 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 509170006929 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 509170006930 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 509170006931 G1 box; other site 509170006932 putative GEF interaction site [polypeptide binding]; other site 509170006933 GTP/Mg2+ binding site [chemical binding]; other site 509170006934 Switch I region; other site 509170006935 G2 box; other site 509170006936 G3 box; other site 509170006937 Switch II region; other site 509170006938 G4 box; other site 509170006939 G5 box; other site 509170006940 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 509170006941 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170006942 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170006943 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 3) 509170006944 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170006945 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170006946 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006947 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170006948 ketol-acid reductoisomerase; Provisional; Region: PRK05479 509170006949 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 509170006950 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 509170006951 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 509170006952 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 509170006953 putative valine binding site [chemical binding]; other site 509170006954 dimer interface [polypeptide binding]; other site 509170006955 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 509170006956 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 509170006957 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 509170006958 PYR/PP interface [polypeptide binding]; other site 509170006959 dimer interface [polypeptide binding]; other site 509170006960 TPP binding site [chemical binding]; other site 509170006961 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 509170006962 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 509170006963 TPP-binding site [chemical binding]; other site 509170006964 dimer interface [polypeptide binding]; other site 509170006965 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 509170006966 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 509170006967 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 509170006968 HIGH motif; other site 509170006969 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 509170006970 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 509170006971 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 509170006972 active site 509170006973 KMSKS motif; other site 509170006974 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 509170006975 tRNA binding surface [nucleotide binding]; other site 509170006976 Lipopolysaccharide-assembly; Region: LptE; pfam04390 509170006977 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 509170006978 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 509170006979 macrolide transporter subunit MacA; Provisional; Region: PRK11578 509170006980 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 509170006981 HlyD family secretion protein; Region: HlyD_3; pfam13437 509170006982 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 509170006983 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 509170006984 Walker A/P-loop; other site 509170006985 ATP binding site [chemical binding]; other site 509170006986 Q-loop/lid; other site 509170006987 ABC transporter signature motif; other site 509170006988 Walker B; other site 509170006989 D-loop; other site 509170006990 H-loop/switch region; other site 509170006991 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 509170006992 FtsX-like permease family; Region: FtsX; pfam02687 509170006993 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 509170006994 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 509170006995 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 509170006996 NAD binding site [chemical binding]; other site 509170006997 homotetramer interface [polypeptide binding]; other site 509170006998 homodimer interface [polypeptide binding]; other site 509170006999 substrate binding site [chemical binding]; other site 509170007000 active site 509170007001 Bax inhibitor 1 like; Region: BaxI_1; cl17691 509170007002 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 509170007003 catalytic site [active] 509170007004 putative active site [active] 509170007005 putative substrate binding site [chemical binding]; other site 509170007006 dimer interface [polypeptide binding]; other site 509170007007 GTPase RsgA; Reviewed; Region: PRK12288 509170007008 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 509170007009 RNA binding site [nucleotide binding]; other site 509170007010 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 509170007011 GTPase/Zn-binding domain interface [polypeptide binding]; other site 509170007012 GTP/Mg2+ binding site [chemical binding]; other site 509170007013 G4 box; other site 509170007014 G5 box; other site 509170007015 G1 box; other site 509170007016 Switch I region; other site 509170007017 G2 box; other site 509170007018 G3 box; other site 509170007019 Switch II region; other site 509170007020 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 509170007021 active site residue [active] 509170007022 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 509170007023 GSH binding site [chemical binding]; other site 509170007024 catalytic residues [active] 509170007025 preprotein translocase subunit SecB; Validated; Region: PRK05751 509170007026 SecA binding site; other site 509170007027 Preprotein binding site; other site 509170007028 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 509170007029 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170007030 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007031 GTP-binding protein Der; Reviewed; Region: PRK00093 509170007032 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 509170007033 G1 box; other site 509170007034 GTP/Mg2+ binding site [chemical binding]; other site 509170007035 Switch I region; other site 509170007036 G2 box; other site 509170007037 Switch II region; other site 509170007038 G3 box; other site 509170007039 G4 box; other site 509170007040 G5 box; other site 509170007041 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 509170007042 G1 box; other site 509170007043 GTP/Mg2+ binding site [chemical binding]; other site 509170007044 Switch I region; other site 509170007045 G2 box; other site 509170007046 G3 box; other site 509170007047 Switch II region; other site 509170007048 G4 box; other site 509170007049 G5 box; other site 509170007050 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 509170007051 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 509170007052 Trp docking motif [polypeptide binding]; other site 509170007053 active site 509170007054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 509170007055 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 509170007056 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 509170007057 TPR motif; other site 509170007058 binding surface 509170007059 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 509170007060 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 509170007061 dimer interface [polypeptide binding]; other site 509170007062 motif 1; other site 509170007063 active site 509170007064 motif 2; other site 509170007065 motif 3; other site 509170007066 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 509170007067 anticodon binding site; other site 509170007068 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 509170007069 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 509170007070 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 509170007071 Helix-turn-helix domain; Region: HTH_25; pfam13413 509170007072 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 509170007073 Evidence 7 : Gene remnant; Product type m : membrane component; fragment of type 4 fimbrial biogenesis protein (part 2) 509170007074 Evidence 7 : Gene remnant; Product type m : membrane component; fragment of type 4 fimbrial biogenesis protein (part 1) 509170007075 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 509170007076 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 509170007077 FeS/SAM binding site; other site 509170007078 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 509170007079 active site 509170007080 multimer interface [polypeptide binding]; other site 509170007081 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 509170007082 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 509170007083 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 509170007084 active site 509170007085 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 509170007086 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 509170007087 carboxy-terminal protease; Provisional; Region: PRK11186 509170007088 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 509170007089 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 509170007090 protein binding site [polypeptide binding]; other site 509170007091 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 509170007092 Catalytic dyad [active] 509170007093 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 509170007094 beta-hexosaminidase; Provisional; Region: PRK05337 509170007095 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 509170007096 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 509170007097 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 509170007098 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 509170007099 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 509170007100 putative catalytic cysteine [active] 509170007101 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (part 3) 509170007102 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (part 2) 509170007103 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (part 1) 509170007104 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 509170007105 ATP-binding site [chemical binding]; other site 509170007106 Gluconate-6-phosphate binding site [chemical binding]; other site 509170007107 Shikimate kinase; Region: SKI; pfam01202 509170007108 GntP family permease; Region: GntP_permease; pfam02447 509170007109 fructuronate transporter; Provisional; Region: PRK10034; cl15264 509170007110 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 509170007111 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 509170007112 active site 509170007113 intersubunit interface [polypeptide binding]; other site 509170007114 catalytic residue [active] 509170007115 phosphogluconate dehydratase; Validated; Region: PRK09054 509170007116 6-phosphogluconate dehydratase; Region: edd; TIGR01196 509170007117 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170007118 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007119 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of phosphate acetyltransferase (partial) 509170007120 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 509170007121 Fumarase C-terminus; Region: Fumerase_C; pfam05683 509170007122 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 509170007123 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 509170007124 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 509170007125 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 509170007126 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170007127 Walker A motif; other site 509170007128 ATP binding site [chemical binding]; other site 509170007129 Walker B motif; other site 509170007130 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 509170007131 Clp protease; Region: CLP_protease; pfam00574 509170007132 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 509170007133 oligomer interface [polypeptide binding]; other site 509170007134 active site residues [active] 509170007135 trigger factor; Provisional; Region: tig; PRK01490 509170007136 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 509170007137 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 509170007138 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 509170007139 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 509170007140 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509170007141 ligand-binding site [chemical binding]; other site 509170007142 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 509170007143 2-isopropylmalate synthase; Validated; Region: PRK03739 509170007144 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 509170007145 active site 509170007146 catalytic residues [active] 509170007147 metal binding site [ion binding]; metal-binding site 509170007148 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 509170007149 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 509170007150 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 509170007151 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509170007152 S-adenosylmethionine binding site [chemical binding]; other site 509170007153 Sel1-like repeats; Region: SEL1; smart00671 509170007154 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 509170007155 Sel1-like repeats; Region: SEL1; smart00671 509170007156 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 509170007157 active site 509170007158 dimerization interface [polypeptide binding]; other site 509170007159 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170007160 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170007161 Membrane transport protein; Region: Mem_trans; cl09117 509170007162 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 509170007163 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 509170007164 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 509170007165 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 509170007166 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170007167 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170007168 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 509170007169 NRDE protein; Region: NRDE; cl01315 509170007170 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 509170007171 thymidylate synthase; Reviewed; Region: thyA; PRK01827 509170007172 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 509170007173 dimerization interface [polypeptide binding]; other site 509170007174 active site 509170007175 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 509170007176 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 509170007177 folate binding site [chemical binding]; other site 509170007178 NADP+ binding site [chemical binding]; other site 509170007179 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 509170007180 methionine sulfoxide reductase A; Provisional; Region: PRK14054 509170007181 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 509170007182 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 509170007183 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 509170007184 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 509170007185 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 509170007186 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 509170007187 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 509170007188 putative active site [active] 509170007189 putative substrate binding site [chemical binding]; other site 509170007190 putative cosubstrate binding site; other site 509170007191 catalytic site [active] 509170007192 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509170007193 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509170007194 Bacterial transcriptional repressor; Region: TetR; pfam13972 509170007195 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 509170007196 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 509170007197 NAD(P) binding site [chemical binding]; other site 509170007198 catalytic residues [active] 509170007199 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 509170007200 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 509170007201 putative cation:proton antiport protein; Provisional; Region: PRK10669 509170007202 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 509170007203 TrkA-N domain; Region: TrkA_N; pfam02254 509170007204 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170007205 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 509170007206 RNA recognition motif; Region: RRM; smart00360 509170007207 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 509170007208 Part of AAA domain; Region: AAA_19; pfam13245 509170007209 Family description; Region: UvrD_C_2; pfam13538 509170007210 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 509170007211 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein; signal peptide 509170007212 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 509170007213 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 509170007214 active site 509170007215 interdomain interaction site; other site 509170007216 putative metal-binding site [ion binding]; other site 509170007217 nucleotide binding site [chemical binding]; other site 509170007218 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 509170007219 domain I; other site 509170007220 DNA binding groove [nucleotide binding] 509170007221 phosphate binding site [ion binding]; other site 509170007222 domain II; other site 509170007223 domain III; other site 509170007224 nucleotide binding site [chemical binding]; other site 509170007225 catalytic site [active] 509170007226 domain IV; other site 509170007227 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 509170007228 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 509170007229 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 509170007230 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 509170007231 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 509170007232 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170007233 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 509170007234 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 509170007235 putative NAD(P) binding site [chemical binding]; other site 509170007236 dimer interface [polypeptide binding]; other site 509170007237 SlyX; Region: SlyX; pfam04102 509170007238 ABC transporter ATPase component; Reviewed; Region: PRK11147 509170007239 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 509170007240 Walker A/P-loop; other site 509170007241 ATP binding site [chemical binding]; other site 509170007242 Q-loop/lid; other site 509170007243 ABC transporter signature motif; other site 509170007244 Walker B; other site 509170007245 D-loop; other site 509170007246 H-loop/switch region; other site 509170007247 ABC transporter; Region: ABC_tran_2; pfam12848 509170007248 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 509170007249 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 509170007250 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 509170007251 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 509170007252 putative acyl-acceptor binding pocket; other site 509170007253 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 509170007254 This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819 509170007255 putative ADP-binding pocket [chemical binding]; other site 509170007256 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 509170007257 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 509170007258 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 509170007259 putative catalytic site [active] 509170007260 putative metal binding site [ion binding]; other site 509170007261 putative phosphate binding site [ion binding]; other site 509170007262 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 509170007263 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 509170007264 FimV N-terminal domain; Region: FimV_core; TIGR03505 509170007265 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170007266 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170007267 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 509170007268 active site 509170007269 homodimer interface [polypeptide binding]; other site 509170007270 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 509170007271 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 509170007272 dimerization interface 3.5A [polypeptide binding]; other site 509170007273 active site 509170007274 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 509170007275 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 509170007276 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509170007277 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 509170007278 rRNA binding site [nucleotide binding]; other site 509170007279 predicted 30S ribosome binding site; other site 509170007280 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 509170007281 tartrate dehydrogenase; Region: TTC; TIGR02089 509170007282 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 509170007283 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 509170007284 substrate binding site [chemical binding]; other site 509170007285 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 509170007286 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 509170007287 substrate binding site [chemical binding]; other site 509170007288 ligand binding site [chemical binding]; other site 509170007289 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170007290 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509170007291 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509170007292 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 509170007293 dimerization interface [polypeptide binding]; other site 509170007294 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 509170007295 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 509170007296 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 509170007297 putative active site [active] 509170007298 Ap4A binding site [chemical binding]; other site 509170007299 nudix motif; other site 509170007300 putative metal binding site [ion binding]; other site 509170007301 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 509170007302 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 509170007303 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 509170007304 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 509170007305 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 509170007306 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170007307 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007308 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170007309 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007310 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 509170007311 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 509170007312 motif II; other site 509170007313 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 509170007314 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 509170007315 RNA binding surface [nucleotide binding]; other site 509170007316 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 509170007317 active site 509170007318 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 509170007319 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 509170007320 homodimer interface [polypeptide binding]; other site 509170007321 oligonucleotide binding site [chemical binding]; other site 509170007322 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 509170007323 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 509170007324 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 509170007325 acyl-activating enzyme (AAE) consensus motif; other site 509170007326 putative AMP binding site [chemical binding]; other site 509170007327 putative active site [active] 509170007328 putative CoA binding site [chemical binding]; other site 509170007329 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509170007330 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509170007331 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 509170007332 putative effector binding pocket; other site 509170007333 putative dimerization interface [polypeptide binding]; other site 509170007334 short chain dehydrogenase; Provisional; Region: PRK12744 509170007335 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 509170007336 NADP binding site [chemical binding]; other site 509170007337 homodimer interface [polypeptide binding]; other site 509170007338 active site 509170007339 substrate binding site [chemical binding]; other site 509170007340 HemN family oxidoreductase; Provisional; Region: PRK05660 509170007341 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 509170007342 FeS/SAM binding site; other site 509170007343 HemN C-terminal domain; Region: HemN_C; pfam06969 509170007344 Protein of unknown function, DUF606; Region: DUF606; pfam04657 509170007345 multidrug efflux protein; Reviewed; Region: PRK01766 509170007346 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 509170007347 cation binding site [ion binding]; other site 509170007348 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 509170007349 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 509170007350 Flavin binding site [chemical binding]; other site 509170007351 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 509170007352 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 509170007353 Flavin binding site [chemical binding]; other site 509170007354 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 509170007355 ABC1 family; Region: ABC1; pfam03109 509170007356 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 509170007357 HopJ type III effector protein; Region: HopJ; pfam08888 509170007358 chromosome condensation membrane protein; Provisional; Region: PRK14196 509170007359 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 509170007360 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 509170007361 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 509170007362 Putative methyltransferase; Region: Methyltransf_4; cl17290 509170007363 Domain of unknown function (DUF329); Region: DUF329; pfam03884 509170007364 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 509170007365 ferrochelatase; Reviewed; Region: hemH; PRK00035 509170007366 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 509170007367 C-terminal domain interface [polypeptide binding]; other site 509170007368 active site 509170007369 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 509170007370 active site 509170007371 N-terminal domain interface [polypeptide binding]; other site 509170007372 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170007373 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170007374 glutamate racemase; Provisional; Region: PRK00865 509170007375 aspartate racemase; Region: asp_race; TIGR00035 509170007376 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 509170007377 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 509170007378 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 509170007379 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 509170007380 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 509170007381 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170007382 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007383 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170007384 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 509170007385 CPxP motif; other site 509170007386 FOG: CBS domain [General function prediction only]; Region: COG0517 509170007387 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 509170007388 Transporter associated domain; Region: CorC_HlyC; smart01091 509170007389 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 509170007390 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 509170007391 putative active site [active] 509170007392 catalytic triad [active] 509170007393 putative dimer interface [polypeptide binding]; other site 509170007394 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 509170007395 dimer interface [polypeptide binding]; other site 509170007396 putative tRNA-binding site [nucleotide binding]; other site 509170007397 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170007398 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007399 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 509170007400 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 509170007401 type II secretion system protein F; Region: GspF; TIGR02120 509170007402 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 509170007403 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 509170007404 primosome assembly protein PriA; Validated; Region: PRK05580 509170007405 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 509170007406 ATP binding site [chemical binding]; other site 509170007407 putative Mg++ binding site [ion binding]; other site 509170007408 helicase superfamily c-terminal domain; Region: HELICc; smart00490 509170007409 ATP-binding site [chemical binding]; other site 509170007410 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 509170007411 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 509170007412 TrkA-N domain; Region: TrkA_N; pfam02254 509170007413 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 509170007414 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 509170007415 dimerization interface [polypeptide binding]; other site 509170007416 domain crossover interface; other site 509170007417 redox-dependent activation switch; other site 509170007418 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 509170007419 Evidence 7 : Gene remnant; Product type f : factor; fragment of curved DNA-binding protein (part 1) 509170007420 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170007421 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007422 Evidence 7 : Gene remnant; Product type f : factor; fragment of curved DNA-binding protein (part 2) 509170007423 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 509170007424 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 509170007425 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 509170007426 oligomer interface [polypeptide binding]; other site 509170007427 metal binding site [ion binding]; metal-binding site 509170007428 metal binding site [ion binding]; metal-binding site 509170007429 putative Cl binding site [ion binding]; other site 509170007430 aspartate ring; other site 509170007431 basic sphincter; other site 509170007432 hydrophobic gate; other site 509170007433 periplasmic entrance; other site 509170007434 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 509170007435 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 509170007436 RNase E interface [polypeptide binding]; other site 509170007437 trimer interface [polypeptide binding]; other site 509170007438 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 509170007439 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 509170007440 RNase E interface [polypeptide binding]; other site 509170007441 trimer interface [polypeptide binding]; other site 509170007442 active site 509170007443 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 509170007444 putative nucleic acid binding region [nucleotide binding]; other site 509170007445 G-X-X-G motif; other site 509170007446 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 509170007447 RNA binding site [nucleotide binding]; other site 509170007448 domain interface; other site 509170007449 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 509170007450 16S/18S rRNA binding site [nucleotide binding]; other site 509170007451 S13e-L30e interaction site [polypeptide binding]; other site 509170007452 25S rRNA binding site [nucleotide binding]; other site 509170007453 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 509170007454 Beta-lactamase; Region: Beta-lactamase; pfam00144 509170007455 AAA domain; Region: AAA_30; pfam13604 509170007456 AAA domain; Region: AAA_22; pfam13401 509170007457 Family description; Region: UvrD_C_2; pfam13538 509170007458 Part of AAA domain; Region: AAA_19; pfam13245 509170007459 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 509170007460 Family description; Region: UvrD_C_2; pfam13538 509170007461 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 509170007462 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 509170007463 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 509170007464 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 509170007465 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 509170007466 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 509170007467 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 509170007468 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 509170007469 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509170007470 S-adenosylmethionine binding site [chemical binding]; other site 509170007471 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 509170007472 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 509170007473 ABC1 family; Region: ABC1; cl17513 509170007474 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 509170007475 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of oxidoreductase; flavoprotein monooxygenase (part 1) 509170007476 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170007477 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007478 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of oxidoreductase; flavoprotein monooxygenase (part 2) 509170007479 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 509170007480 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 509170007481 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 509170007482 metal binding site [ion binding]; metal-binding site 509170007483 Family description; Region: UvrD_C_2; pfam13538 509170007484 AAA domain; Region: AAA_23; pfam13476 509170007485 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 509170007486 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 509170007487 Domain of unknown function (DUF4040); Region: DUF4040; pfam13244 509170007488 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 509170007489 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 509170007490 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 509170007491 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 509170007492 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 509170007493 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 509170007494 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 509170007495 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 509170007496 ribosome-binding factor A; Provisional; Region: PRK13816 509170007497 translation initiation factor IF-2; Region: IF-2; TIGR00487 509170007498 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 509170007499 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 509170007500 G1 box; other site 509170007501 putative GEF interaction site [polypeptide binding]; other site 509170007502 GTP/Mg2+ binding site [chemical binding]; other site 509170007503 Switch I region; other site 509170007504 G2 box; other site 509170007505 G3 box; other site 509170007506 Switch II region; other site 509170007507 G4 box; other site 509170007508 G5 box; other site 509170007509 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 509170007510 Translation-initiation factor 2; Region: IF-2; pfam11987 509170007511 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 509170007512 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 509170007513 NusA N-terminal domain; Region: NusA_N; pfam08529 509170007514 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 509170007515 RNA binding site [nucleotide binding]; other site 509170007516 homodimer interface [polypeptide binding]; other site 509170007517 NusA-like KH domain; Region: KH_5; pfam13184 509170007518 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 509170007519 G-X-X-G motif; other site 509170007520 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 509170007521 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 509170007522 Sm and related proteins; Region: Sm_like; cl00259 509170007523 ribosome maturation protein RimP; Reviewed; Region: PRK00092 509170007524 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 509170007525 putative oligomer interface [polypeptide binding]; other site 509170007526 putative RNA binding site [nucleotide binding]; other site 509170007527 Preprotein translocase SecG subunit; Region: SecG; pfam03840 509170007528 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 509170007529 triosephosphate isomerase; Provisional; Region: PRK14567 509170007530 substrate binding site [chemical binding]; other site 509170007531 dimer interface [polypeptide binding]; other site 509170007532 catalytic triad [active] 509170007533 Evidence 7 : Gene remnant; Product type t : transporter; fragment of type 4 fimbrial biogenesis protein (part 1) 509170007534 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170007535 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007536 Evidence 7 : Gene remnant; Product type t : transporter; fragment of type 4 fimbrial biogenesis protein (part 2) 509170007537 Evidence 7 : Gene remnant; Product type m : membrane component; fragment of type 4 fimbrial assembly protein (part 1) 509170007538 Evidence 7 : Gene remnant; Product type m : membrane component; fragment of type 4 fimbrial assembly protein (part 2) 509170007539 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 509170007540 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 509170007541 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 509170007542 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 509170007543 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 509170007544 CoA-binding site [chemical binding]; other site 509170007545 ATP-binding [chemical binding]; other site 509170007546 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 509170007547 EamA-like transporter family; Region: EamA; pfam00892 509170007548 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 509170007549 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 509170007550 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 509170007551 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 509170007552 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 509170007553 binding surface 509170007554 Tetratricopeptide repeat; Region: TPR_16; pfam13432 509170007555 TPR motif; other site 509170007556 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 509170007557 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 509170007558 Walker A/P-loop; other site 509170007559 ATP binding site [chemical binding]; other site 509170007560 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 509170007561 ABC transporter signature motif; other site 509170007562 Walker B; other site 509170007563 D-loop; other site 509170007564 H-loop/switch region; other site 509170007565 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 509170007566 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 509170007567 multidrug resistance protein MdtN; Provisional; Region: PRK10476 509170007568 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 509170007569 HlyD family secretion protein; Region: HlyD_3; pfam13437 509170007570 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 509170007571 Fusaric acid resistance protein family; Region: FUSC; pfam04632 509170007572 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 509170007573 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 509170007574 Transcriptional regulator [Transcription]; Region: IclR; COG1414 509170007575 Bacterial transcriptional regulator; Region: IclR; pfam01614 509170007576 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 509170007577 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of bifunctional protein [Includes: transcriptional regulator of DNA repair (AraC/Xyl family); O6-methylguanine-DNA methyltransferase] (part 2) 509170007578 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170007579 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170007580 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of bifunctional protein [Includes: transcriptional regulator of DNA repair (AraC/Xyl family); O6-methylguanine-DNA methyltransferase] (part 1) 509170007581 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 509170007582 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 509170007583 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 509170007584 active site 509170007585 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II; cd00556 509170007586 active site 509170007587 dimer interface [polypeptide binding]; other site 509170007588 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 509170007589 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 509170007590 GIY-YIG motif/motif A; other site 509170007591 active site 509170007592 catalytic site [active] 509170007593 putative DNA binding site [nucleotide binding]; other site 509170007594 metal binding site [ion binding]; metal-binding site 509170007595 UvrB/uvrC motif; Region: UVR; pfam02151 509170007596 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 509170007597 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 509170007598 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 509170007599 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 509170007600 substrate binding site [chemical binding]; other site 509170007601 oxyanion hole (OAH) forming residues; other site 509170007602 trimer interface [polypeptide binding]; other site 509170007603 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 509170007604 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 509170007605 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 509170007606 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 509170007607 dimer interface [polypeptide binding]; other site 509170007608 active site 509170007609 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 509170007610 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 509170007611 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170007612 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007613 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170007614 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170007615 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170007616 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170007617 heat shock protein 90; Provisional; Region: PRK05218 509170007618 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509170007619 ATP binding site [chemical binding]; other site 509170007620 Mg2+ binding site [ion binding]; other site 509170007621 G-X-G motif; other site 509170007622 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 509170007623 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 509170007624 Predicted permease [General function prediction only]; Region: COG2056 509170007625 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 509170007626 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 509170007627 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 509170007628 active site 2 [active] 509170007629 active site 1 [active] 509170007630 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170007631 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170007632 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 509170007633 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 509170007634 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 509170007635 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 509170007636 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 509170007637 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 509170007638 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 509170007639 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 509170007640 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 509170007641 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 509170007642 DNA binding site [nucleotide binding] 509170007643 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 509170007644 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 509170007645 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 509170007646 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 509170007647 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 509170007648 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 509170007649 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 509170007650 RPB1 interaction site [polypeptide binding]; other site 509170007651 RPB11 interaction site [polypeptide binding]; other site 509170007652 RPB10 interaction site [polypeptide binding]; other site 509170007653 RPB3 interaction site [polypeptide binding]; other site 509170007654 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 509170007655 core dimer interface [polypeptide binding]; other site 509170007656 peripheral dimer interface [polypeptide binding]; other site 509170007657 L10 interface [polypeptide binding]; other site 509170007658 L11 interface [polypeptide binding]; other site 509170007659 putative EF-Tu interaction site [polypeptide binding]; other site 509170007660 putative EF-G interaction site [polypeptide binding]; other site 509170007661 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 509170007662 23S rRNA interface [nucleotide binding]; other site 509170007663 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 509170007664 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 509170007665 mRNA/rRNA interface [nucleotide binding]; other site 509170007666 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 509170007667 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 509170007668 23S rRNA interface [nucleotide binding]; other site 509170007669 L7/L12 interface [polypeptide binding]; other site 509170007670 putative thiostrepton binding site; other site 509170007671 L25 interface [polypeptide binding]; other site 509170007672 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 509170007673 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 509170007674 putative homodimer interface [polypeptide binding]; other site 509170007675 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 509170007676 heterodimer interface [polypeptide binding]; other site 509170007677 homodimer interface [polypeptide binding]; other site 509170007678 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 509170007679 elongation factor Tu; Reviewed; Region: PRK00049 509170007680 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 509170007681 G1 box; other site 509170007682 GEF interaction site [polypeptide binding]; other site 509170007683 GTP/Mg2+ binding site [chemical binding]; other site 509170007684 Switch I region; other site 509170007685 G2 box; other site 509170007686 G3 box; other site 509170007687 Switch II region; other site 509170007688 G4 box; other site 509170007689 G5 box; other site 509170007690 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 509170007691 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 509170007692 Antibiotic Binding Site [chemical binding]; other site 509170007693 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of anthranilate synthase component I (part 2) 509170007694 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of anthranilate synthase component I (part 1) 509170007695 phosphoglycolate phosphatase; Provisional; Region: PRK13222 509170007696 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 509170007697 motif II; other site 509170007698 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 509170007699 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 509170007700 phosphopeptide binding site; other site 509170007701 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 509170007702 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 509170007703 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 509170007704 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 509170007705 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 509170007706 type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713 509170007707 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 509170007708 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 509170007709 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 509170007710 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170007711 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170007712 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007713 Evidence 7 : Gene remnant; Product type r : regulator; fragment of alginate biosynthesis protein (part 1) 509170007714 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 509170007715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509170007716 active site 509170007717 phosphorylation site [posttranslational modification] 509170007718 intermolecular recognition site; other site 509170007719 dimerization interface [polypeptide binding]; other site 509170007720 LytTr DNA-binding domain; Region: LytTR; smart00850 509170007721 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 509170007722 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 509170007723 domain interfaces; other site 509170007724 active site 509170007725 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 509170007726 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 509170007727 active site 509170007728 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 509170007729 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 509170007730 active site 509170007731 H-NS histone family; Region: Histone_HNS; pfam00816 509170007732 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 509170007733 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170007734 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007735 Evidence 7 : Gene remnant; Product type r : regulator; fragment of alginate biosynthesis protein (part 2) 509170007736 Evidence 7 : Gene remnant; Product type r : regulator; fragment of alginate biosynthesis protein (part 1) 509170007737 argininosuccinate lyase; Provisional; Region: PRK00855 509170007738 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 509170007739 active sites [active] 509170007740 tetramer interface [polypeptide binding]; other site 509170007741 oxidative damage protection protein; Provisional; Region: PRK05408 509170007742 transcriptional regulator PhoU; Provisional; Region: PRK11115 509170007743 PhoU domain; Region: PhoU; pfam01895 509170007744 PhoU domain; Region: PhoU; pfam01895 509170007745 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 509170007746 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170007747 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170007748 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509170007749 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509170007750 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170007751 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170007752 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 509170007753 ThiC-associated domain; Region: ThiC-associated; pfam13667 509170007754 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 509170007755 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 509170007756 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 509170007757 dimer interface [polypeptide binding]; other site 509170007758 ADP-ribose binding site [chemical binding]; other site 509170007759 active site 509170007760 nudix motif; other site 509170007761 metal binding site [ion binding]; metal-binding site 509170007762 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 509170007763 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 509170007764 active site 509170007765 metal binding site [ion binding]; metal-binding site 509170007766 hexamer interface [polypeptide binding]; other site 509170007767 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 509170007768 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 509170007769 active site 509170007770 nucleotide binding site [chemical binding]; other site 509170007771 HIGH motif; other site 509170007772 KMSKS motif; other site 509170007773 cell division protein FtsW; Region: ftsW; TIGR02614 509170007774 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 509170007775 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 509170007776 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 509170007777 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 509170007778 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 509170007779 G1 box; other site 509170007780 GTP/Mg2+ binding site [chemical binding]; other site 509170007781 Switch I region; other site 509170007782 G2 box; other site 509170007783 G3 box; other site 509170007784 Switch II region; other site 509170007785 G4 box; other site 509170007786 G5 box; other site 509170007787 Nucleoside recognition; Region: Gate; pfam07670 509170007788 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 509170007789 Nucleoside recognition; Region: Gate; pfam07670 509170007790 FeoA domain; Region: FeoA; pfam04023 509170007791 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 509170007792 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 509170007793 active site 509170007794 DNA binding site [nucleotide binding] 509170007795 Int/Topo IB signature motif; other site 509170007796 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 509170007797 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 509170007798 dimerization domain [polypeptide binding]; other site 509170007799 dimer interface [polypeptide binding]; other site 509170007800 catalytic residues [active] 509170007801 homoserine dehydrogenase; Provisional; Region: PRK06349 509170007802 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 509170007803 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 509170007804 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 509170007805 threonine synthase; Reviewed; Region: PRK06721 509170007806 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 509170007807 homodimer interface [polypeptide binding]; other site 509170007808 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170007809 catalytic residue [active] 509170007810 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 509170007811 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 509170007812 response regulator; Provisional; Region: PRK09483 509170007813 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509170007814 active site 509170007815 phosphorylation site [posttranslational modification] 509170007816 intermolecular recognition site; other site 509170007817 dimerization interface [polypeptide binding]; other site 509170007818 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 509170007819 DNA binding residues [nucleotide binding] 509170007820 dimerization interface [polypeptide binding]; other site 509170007821 Evidence 7 : Gene remnant; Product type r : regulator; fragment of sensor protein (part 1) 509170007822 Evidence 7 : Gene remnant; Product type r : regulator; fragment of sensor protein (part 2) 509170007823 Evidence 7 : Gene remnant; Product type r : regulator; fragment of type 4 fimbriae expression regulatory protein (part 1) 509170007824 Evidence 7 : Gene remnant; Product type r : regulator; fragment of type 4 fimbriae expression regulatory protein (part 2) 509170007825 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170007826 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007827 X;Evidence 7 : Gene remnant; Product type r : regulator; fragment of type 4 fimbriae expression regulatory protein (part 3) 509170007828 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 509170007829 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 509170007830 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 509170007831 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 509170007832 Catalytic dyad [active] 509170007833 phosphoglyceromutase; Provisional; Region: PRK05434 509170007834 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 509170007835 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 509170007836 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 509170007837 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 509170007838 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 509170007839 multifunctional aminopeptidase A; Provisional; Region: PRK00913 509170007840 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 509170007841 interface (dimer of trimers) [polypeptide binding]; other site 509170007842 Substrate-binding/catalytic site; other site 509170007843 Zn-binding sites [ion binding]; other site 509170007844 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 509170007845 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 509170007846 Lumazine binding domain; Region: Lum_binding; pfam00677 509170007847 Lumazine binding domain; Region: Lum_binding; pfam00677 509170007848 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 509170007849 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 509170007850 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 509170007851 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 509170007852 catalytic motif [active] 509170007853 Zn binding site [ion binding]; other site 509170007854 RibD C-terminal domain; Region: RibD_C; cl17279 509170007855 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 509170007856 ATP cone domain; Region: ATP-cone; pfam03477 509170007857 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 509170007858 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 509170007859 Nitrogen regulatory protein P-II; Region: P-II; smart00938 509170007860 Membrane fusogenic activity; Region: BMFP; pfam04380 509170007861 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of magnesium chelatase, competence related protein (ComM) (partial) 509170007862 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 509170007863 active site 509170007864 8-oxo-dGMP binding site [chemical binding]; other site 509170007865 nudix motif; other site 509170007866 metal binding site [ion binding]; metal-binding site 509170007867 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 509170007868 Domain of unknown function (DUF955); Region: DUF955; cl01076 509170007869 Thymidylate synthase; Region: Thymidylat_synt; pfam00303 509170007870 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 509170007871 dimerization interface [polypeptide binding]; other site 509170007872 active site 509170007873 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 509170007874 TniQ; Region: TniQ; pfam06527 509170007875 Bacterial TniB protein; Region: TniB; pfam05621 509170007876 AAA domain; Region: AAA_22; pfam13401 509170007877 Winged helix-turn helix; Region: HTH_29; pfam13551 509170007878 Integrase core domain; Region: rve; pfam00665 509170007879 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 509170007880 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 509170007881 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 509170007882 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 509170007883 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 509170007884 glutamine binding [chemical binding]; other site 509170007885 catalytic triad [active] 509170007886 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 509170007887 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 509170007888 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 509170007889 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170007890 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007891 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170007892 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007893 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 509170007894 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of magnesium chelatase, competence related protein (ComM) (partial) 509170007895 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170007896 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007897 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 509170007898 amphipathic channel; other site 509170007899 Asn-Pro-Ala signature motifs; other site 509170007900 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170007901 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170007902 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007903 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170007904 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007905 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 509170007906 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 509170007907 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 509170007908 active site 509170007909 substrate binding site [chemical binding]; other site 509170007910 Mg2+ binding site [ion binding]; other site 509170007911 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 509170007912 potassium uptake protein; Region: kup; TIGR00794 509170007913 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170007914 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170007915 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170007916 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170007917 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170007918 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170007919 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170007920 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007921 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of transcriptional regulator (TetR family) (partial) 509170007922 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 509170007923 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509170007924 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 509170007925 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 509170007926 active site 509170007927 catalytic tetrad [active] 509170007928 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170007929 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170007930 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 509170007931 EamA-like transporter family; Region: EamA; pfam00892 509170007932 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 509170007933 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509170007934 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509170007935 dimerization interface [polypeptide binding]; other site 509170007936 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170007937 putative substrate translocation pore; other site 509170007938 Major Facilitator Superfamily; Region: MFS_1; pfam07690 509170007939 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170007940 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007941 Uncharacterized conserved protein [Function unknown]; Region: COG3791 509170007942 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509170007943 S-adenosylmethionine binding site [chemical binding]; other site 509170007944 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 509170007945 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 509170007946 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170007947 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170007948 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007949 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170007950 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of transcriptional regulator (LysR family) (partial) 509170007951 succinic semialdehyde dehydrogenase; Region: PLN02278 509170007952 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 509170007953 tetramerization interface [polypeptide binding]; other site 509170007954 NAD(P) binding site [chemical binding]; other site 509170007955 catalytic residues [active] 509170007956 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 509170007957 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 509170007958 inhibitor-cofactor binding pocket; inhibition site 509170007959 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170007960 catalytic residue [active] 509170007961 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 509170007962 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509170007963 DNA-binding site [nucleotide binding]; DNA binding site 509170007964 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 509170007965 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170007966 homodimer interface [polypeptide binding]; other site 509170007967 catalytic residue [active] 509170007968 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 509170007969 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 509170007970 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 509170007971 non-specific DNA binding site [nucleotide binding]; other site 509170007972 salt bridge; other site 509170007973 sequence-specific DNA binding site [nucleotide binding]; other site 509170007974 Cupin domain; Region: Cupin_2; pfam07883 509170007975 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein; membrane protein (part 1) 509170007976 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein; membrane protein (part 2) 509170007977 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 509170007978 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 509170007979 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 509170007980 dimer interface [polypeptide binding]; other site 509170007981 ssDNA binding site [nucleotide binding]; other site 509170007982 tetramer (dimer of dimers) interface [polypeptide binding]; other site 509170007983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170007984 Major Facilitator Superfamily; Region: MFS_1; pfam07690 509170007985 putative substrate translocation pore; other site 509170007986 hypothetical protein; Provisional; Region: PRK14013 509170007987 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170007988 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007989 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170007990 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170007991 Putative transcription activator [Transcription]; Region: TenA; COG0819 509170007992 GlpM protein; Region: GlpM; pfam06942 509170007993 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 509170007994 2-enoyl thioester reductase (ETR) like proteins, child 2; Region: ETR_like_2; cd08292 509170007995 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 509170007996 putative NAD(P) binding site [chemical binding]; other site 509170007997 putative dimer interface [polypeptide binding]; other site 509170007998 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509170007999 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509170008000 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 509170008001 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 509170008002 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 509170008003 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 509170008004 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 509170008005 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 509170008006 metal binding site [ion binding]; metal-binding site 509170008007 active site 509170008008 I-site; other site 509170008009 BCCT family transporter; Region: BCCT; pfam02028 509170008010 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170008011 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170008012 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170008013 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 509170008014 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 509170008015 Transposase; Region: DDE_Tnp_ISL3; pfam01610 509170008016 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 509170008017 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 509170008018 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 509170008019 ATP binding site [chemical binding]; other site 509170008020 putative Mg++ binding site [ion binding]; other site 509170008021 Abi-like protein; Region: Abi_2; pfam07751 509170008022 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 509170008023 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 509170008024 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 509170008025 HsdM N-terminal domain; Region: HsdM_N; pfam12161 509170008026 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170008027 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170008028 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170008029 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170008030 PAAR motif; Region: PAAR_motif; pfam05488 509170008031 PAAR motif; Region: PAAR_motif; pfam05488 509170008032 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170008033 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170008034 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170008035 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 509170008036 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 509170008037 Na binding site [ion binding]; other site 509170008038 Protein of unknown function, DUF485; Region: DUF485; pfam04341 509170008039 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 509170008040 Na binding site [ion binding]; other site 509170008041 PAS fold; Region: PAS_7; pfam12860 509170008042 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 509170008043 putative active site [active] 509170008044 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 509170008045 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509170008046 dimer interface [polypeptide binding]; other site 509170008047 phosphorylation site [posttranslational modification] 509170008048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509170008049 ATP binding site [chemical binding]; other site 509170008050 Mg2+ binding site [ion binding]; other site 509170008051 G-X-G motif; other site 509170008052 Response regulator receiver domain; Region: Response_reg; pfam00072 509170008053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509170008054 active site 509170008055 phosphorylation site [posttranslational modification] 509170008056 intermolecular recognition site; other site 509170008057 dimerization interface [polypeptide binding]; other site 509170008058 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 509170008059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509170008060 active site 509170008061 phosphorylation site [posttranslational modification] 509170008062 intermolecular recognition site; other site 509170008063 dimerization interface [polypeptide binding]; other site 509170008064 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 509170008065 DNA binding residues [nucleotide binding] 509170008066 dimerization interface [polypeptide binding]; other site 509170008067 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 509170008068 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 509170008069 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 509170008070 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 509170008071 active site 509170008072 dimer interface [polypeptide binding]; other site 509170008073 non-prolyl cis peptide bond; other site 509170008074 insertion regions; other site 509170008075 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170008076 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170008077 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 509170008078 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 509170008079 dimerization interface [polypeptide binding]; other site 509170008080 putative DNA binding site [nucleotide binding]; other site 509170008081 putative Zn2+ binding site [ion binding]; other site 509170008082 AsnC family; Region: AsnC_trans_reg; pfam01037 509170008083 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of isochorismatase (partial) 509170008084 acetyl-CoA synthetase; Provisional; Region: PRK00174 509170008085 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 509170008086 active site 509170008087 CoA binding site [chemical binding]; other site 509170008088 acyl-activating enzyme (AAE) consensus motif; other site 509170008089 AMP binding site [chemical binding]; other site 509170008090 acetate binding site [chemical binding]; other site 509170008091 Protein of unknown function (DUF805); Region: DUF805; pfam05656 509170008092 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 509170008093 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 509170008094 Mechanosensitive ion channel; Region: MS_channel; pfam00924 509170008095 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 509170008096 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 509170008097 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 509170008098 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 509170008099 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 509170008100 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 509170008101 FMN binding site [chemical binding]; other site 509170008102 active site 509170008103 substrate binding site [chemical binding]; other site 509170008104 catalytic residue [active] 509170008105 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 509170008106 putative DNA binding site [nucleotide binding]; other site 509170008107 dimerization interface [polypeptide binding]; other site 509170008108 putative Zn2+ binding site [ion binding]; other site 509170008109 peptide chain release factor 2; Provisional; Region: PRK08787 509170008110 This domain is found in peptide chain release factors; Region: PCRF; smart00937 509170008111 RF-1 domain; Region: RF-1; pfam00472 509170008112 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 509170008113 DHH family; Region: DHH; pfam01368 509170008114 DHHA1 domain; Region: DHHA1; pfam02272 509170008115 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 509170008116 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 509170008117 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 509170008118 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 509170008119 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 509170008120 active site 509170008121 substrate binding site [chemical binding]; other site 509170008122 metal binding site [ion binding]; metal-binding site 509170008123 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 509170008124 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 509170008125 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 509170008126 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 509170008127 active site 509170008128 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 509170008129 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 509170008130 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 509170008131 Evidence 7 : Gene remnant; Product type prc : receptor; fragment of ferric siderophore receptor protein (part 1) 509170008132 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170008133 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170008134 Evidence 7 : Gene remnant; Product type prc : receptor; fragment of ferric siderophore receptor protein (part 2) 509170008135 Predicted membrane protein [Function unknown]; Region: COG2119 509170008136 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 509170008137 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 509170008138 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170008139 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170008140 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 509170008141 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 509170008142 E3 interaction surface; other site 509170008143 lipoyl attachment site [posttranslational modification]; other site 509170008144 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 509170008145 E3 interaction surface; other site 509170008146 lipoyl attachment site [posttranslational modification]; other site 509170008147 e3 binding domain; Region: E3_binding; pfam02817 509170008148 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 509170008149 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 509170008150 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 509170008151 dimer interface [polypeptide binding]; other site 509170008152 TPP-binding site [chemical binding]; other site 509170008153 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 509170008154 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 509170008155 Peptidase family M23; Region: Peptidase_M23; pfam01551 509170008156 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 509170008157 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 509170008158 cell division protein FtsZ; Validated; Region: PRK09330 509170008159 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 509170008160 nucleotide binding site [chemical binding]; other site 509170008161 SulA interaction site; other site 509170008162 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 509170008163 Cell division protein FtsA; Region: FtsA; smart00842 509170008164 Cell division protein FtsA; Region: FtsA; pfam14450 509170008165 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 509170008166 Cell division protein FtsQ; Region: FtsQ; pfam03799 509170008167 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 509170008168 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 509170008169 ATP-grasp domain; Region: ATP-grasp_4; cl17255 509170008170 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 509170008171 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 509170008172 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 509170008173 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 509170008174 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 509170008175 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 509170008176 active site 509170008177 homodimer interface [polypeptide binding]; other site 509170008178 glutathione synthetase; Provisional; Region: PRK05246 509170008179 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 509170008180 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 509170008181 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 509170008182 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170008183 Mor transcription activator family; Region: Mor; cl02360 509170008184 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : receptor; fragment of ferric siderophore receptor protein (part 1) 509170008185 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170008186 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170008187 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : receptor; fragment of ferric siderophore receptor protein (part 2) 509170008188 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 509170008189 active site 509170008190 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 509170008191 putative active site [active] 509170008192 putative catalytic site [active] 509170008193 putative DNA binding site [nucleotide binding]; other site 509170008194 putative phosphate binding site [ion binding]; other site 509170008195 metal binding site A [ion binding]; metal-binding site 509170008196 putative AP binding site [nucleotide binding]; other site 509170008197 putative metal binding site B [ion binding]; other site 509170008198 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 509170008199 ArsC family; Region: ArsC; pfam03960 509170008200 putative catalytic residues [active] 509170008201 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 509170008202 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 509170008203 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 509170008204 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 509170008205 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 509170008206 metal binding site [ion binding]; metal-binding site 509170008207 active site 509170008208 I-site; other site 509170008209 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 509170008210 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 509170008211 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 509170008212 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 509170008213 DsbD alpha interface [polypeptide binding]; other site 509170008214 catalytic residues [active] 509170008215 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 509170008216 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 509170008217 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 509170008218 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 509170008219 30S subunit binding site; other site 509170008220 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 509170008221 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 509170008222 active site 509170008223 catalytic site [active] 509170008224 tetramer interface [polypeptide binding]; other site 509170008225 putative OHCU decarboxylase; Provisional; Region: PRK13798 509170008226 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 509170008227 active site 509170008228 homotetramer interface [polypeptide binding]; other site 509170008229 xanthine permease; Region: pbuX; TIGR03173 509170008230 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170008231 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170008232 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170008233 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170008234 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170008235 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170008236 hypothetical protein; Provisional; Region: PRK07236 509170008237 FAD binding domain; Region: FAD_binding_3; pfam01494 509170008238 allantoicase; Provisional; Region: PRK13257 509170008239 Allantoicase repeat; Region: Allantoicase; pfam03561 509170008240 Allantoicase repeat; Region: Allantoicase; pfam03561 509170008241 ureidoglycolate hydrolase; Provisional; Region: PRK03606 509170008242 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 509170008243 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 509170008244 classical (c) SDRs; Region: SDR_c; cd05233 509170008245 NAD(P) binding site [chemical binding]; other site 509170008246 active site 509170008247 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170008248 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170008249 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 509170008250 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509170008251 ATP binding site [chemical binding]; other site 509170008252 Mg2+ binding site [ion binding]; other site 509170008253 G-X-G motif; other site 509170008254 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 509170008255 anchoring element; other site 509170008256 dimer interface [polypeptide binding]; other site 509170008257 ATP binding site [chemical binding]; other site 509170008258 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 509170008259 active site 509170008260 metal binding site [ion binding]; metal-binding site 509170008261 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 509170008262 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 509170008263 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 509170008264 PGAP1-like protein; Region: PGAP1; pfam07819 509170008265 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 509170008266 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170008267 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170008268 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170008269 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170008270 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170008271 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170008272 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 509170008273 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 509170008274 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 509170008275 Protein of unknown function (DUF445); Region: DUF445; pfam04286 509170008276 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of aminotransferase (part 1) 509170008277 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of aminotransferase (part 2) 509170008278 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 509170008279 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 509170008280 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170008281 short chain dehydrogenase; Provisional; Region: PRK07832 509170008282 NAD(P) binding site [chemical binding]; other site 509170008283 active site 509170008284 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509170008285 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 509170008286 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509170008287 active site 509170008288 phosphorylation site [posttranslational modification] 509170008289 intermolecular recognition site; other site 509170008290 dimerization interface [polypeptide binding]; other site 509170008291 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 509170008292 DNA binding site [nucleotide binding] 509170008293 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 509170008294 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 509170008295 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509170008296 putative active site [active] 509170008297 heme pocket [chemical binding]; other site 509170008298 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509170008299 dimer interface [polypeptide binding]; other site 509170008300 phosphorylation site [posttranslational modification] 509170008301 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509170008302 ATP binding site [chemical binding]; other site 509170008303 Mg2+ binding site [ion binding]; other site 509170008304 G-X-G motif; other site 509170008305 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein; secretory lipase precursor (part 2) 509170008306 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein; secretory lipase precursor (part 1) 509170008307 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 509170008308 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 509170008309 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 509170008310 active site residue [active] 509170008311 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 509170008312 active site residue [active] 509170008313 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 509170008314 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 509170008315 active site 509170008316 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 509170008317 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 509170008318 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 509170008319 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 509170008320 tetramer interface [polypeptide binding]; other site 509170008321 heme binding pocket [chemical binding]; other site 509170008322 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 509170008323 putative active site [active] 509170008324 dimerization interface [polypeptide binding]; other site 509170008325 putative tRNAtyr binding site [nucleotide binding]; other site 509170008326 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170008327 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170008328 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170008329 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of hydrolase (partial) 509170008330 glutamate racemase; Provisional; Region: PRK00865 509170008331 SIR2-like domain; Region: SIR2_2; pfam13289 509170008332 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 509170008333 multiple promoter invertase; Provisional; Region: mpi; PRK13413 509170008334 catalytic residues [active] 509170008335 catalytic nucleophile [active] 509170008336 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 509170008337 Putative phage integrase; Region: Phage_Integr_2; pfam13009 509170008338 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 509170008339 DNA binding site [nucleotide binding] 509170008340 active site 509170008341 Int/Topo IB signature motif; other site 509170008342 catalytic residues [active] 509170008343 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 509170008344 DNA binding site [nucleotide binding] 509170008345 active site 509170008346 Int/Topo IB signature motif; other site 509170008347 catalytic residues [active] 509170008348 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 509170008349 active site 509170008350 AAA domain; Region: AAA_21; pfam13304 509170008351 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 509170008352 ABC transporter signature motif; other site 509170008353 Walker B; other site 509170008354 D-loop; other site 509170008355 H-loop/switch region; other site 509170008356 haemagglutination activity domain; Region: Haemagg_act; pfam05860 509170008357 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 509170008358 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 509170008359 RTX toxin acyltransferase family; Region: HlyC; cl01131 509170008360 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 509170008361 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 509170008362 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 509170008363 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 509170008364 Homeodomain-like domain; Region: HTH_23; pfam13384 509170008365 Integrase core domain; Region: rve; pfam00665 509170008366 transposase/IS protein; Provisional; Region: PRK09183 509170008367 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 509170008368 Walker A motif; other site 509170008369 ATP binding site [chemical binding]; other site 509170008370 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 509170008371 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 509170008372 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 509170008373 HsdM N-terminal domain; Region: HsdM_N; pfam12161 509170008374 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 509170008375 Methyltransferase domain; Region: Methyltransf_26; pfam13659 509170008376 AAA domain; Region: AAA_22; pfam13401 509170008377 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170008378 Walker A motif; other site 509170008379 ATP binding site [chemical binding]; other site 509170008380 Walker B motif; other site 509170008381 Tn7 transposition regulator TnsC; Region: Tn7_TnsC_Int; pfam11426 509170008382 Integrase core domain; Region: rve; pfam00665 509170008383 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 509170008384 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 509170008385 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 509170008386 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 509170008387 glutaminase active site [active] 509170008388 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 509170008389 dimer interface [polypeptide binding]; other site 509170008390 active site 509170008391 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 509170008392 dimer interface [polypeptide binding]; other site 509170008393 active site 509170008394 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 509170008395 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 509170008396 Substrate binding site; other site 509170008397 Mg++ binding site; other site 509170008398 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 509170008399 active site 509170008400 substrate binding site [chemical binding]; other site 509170008401 CoA binding site [chemical binding]; other site 509170008402 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 509170008403 tetramer interfaces [polypeptide binding]; other site 509170008404 binuclear metal-binding site [ion binding]; other site 509170008405 thiamine monophosphate kinase; Provisional; Region: PRK05731 509170008406 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 509170008407 ATP binding site [chemical binding]; other site 509170008408 dimerization interface [polypeptide binding]; other site 509170008409 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 509170008410 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 509170008411 homopentamer interface [polypeptide binding]; other site 509170008412 active site 509170008413 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 509170008414 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 509170008415 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 509170008416 dimerization interface [polypeptide binding]; other site 509170008417 active site 509170008418 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 509170008419 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 509170008420 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 509170008421 phosphoserine phosphatase SerB; Region: serB; TIGR00338 509170008422 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 509170008423 motif II; other site 509170008424 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170008425 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170008426 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 509170008427 agmatinase; Region: agmatinase; TIGR01230 509170008428 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 509170008429 putative active site [active] 509170008430 putative metal binding site [ion binding]; other site 509170008431 imidazolonepropionase; Validated; Region: PRK09356 509170008432 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 509170008433 active site 509170008434 putative proline-specific permease; Provisional; Region: proY; PRK10580 509170008435 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 509170008436 active sites [active] 509170008437 tetramer interface [polypeptide binding]; other site 509170008438 urocanate hydratase; Provisional; Region: PRK05414 509170008439 HutD; Region: HutD; pfam05962 509170008440 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 509170008441 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509170008442 DNA-binding site [nucleotide binding]; DNA binding site 509170008443 UTRA domain; Region: UTRA; pfam07702 509170008444 Acyltransferase family; Region: Acyl_transf_3; pfam01757 509170008445 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of regulatory protein (nitrile hydratase activator like) (part 2) 509170008446 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170008447 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170008448 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of regulatory protein (nitrile hydratase activator like) (part 1) 509170008449 Peptidase M15; Region: Peptidase_M15_3; cl01194 509170008450 aromatic amino acid transporter; Provisional; Region: PRK10238 509170008451 fumarylacetoacetase; Region: PLN02856 509170008452 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 509170008453 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 509170008454 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 509170008455 maleylacetoacetate isomerase; Region: maiA; TIGR01262 509170008456 C-terminal domain interface [polypeptide binding]; other site 509170008457 GSH binding site (G-site) [chemical binding]; other site 509170008458 putative dimer interface [polypeptide binding]; other site 509170008459 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 509170008460 dimer interface [polypeptide binding]; other site 509170008461 N-terminal domain interface [polypeptide binding]; other site 509170008462 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 509170008463 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 509170008464 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 509170008465 Zn binding site [ion binding]; other site 509170008466 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 509170008467 Transcriptional regulator [Transcription]; Region: IclR; COG1414 509170008468 Bacterial transcriptional regulator; Region: IclR; pfam01614 509170008469 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 509170008470 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 509170008471 dimer interface [polypeptide binding]; other site 509170008472 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 509170008473 active site 509170008474 Fe binding site [ion binding]; other site 509170008475 Uncharacterized conserved protein [Function unknown]; Region: COG1683 509170008476 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of multidrug resistance transporter (part 2) 509170008477 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of multidrug resistance transporter (part 1) 509170008478 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170008479 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170008480 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170008481 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170008482 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 509170008483 Sodium Bile acid symporter family; Region: SBF; pfam01758 509170008484 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 509170008485 Isochorismatase family; Region: Isochorismatase; pfam00857 509170008486 catalytic triad [active] 509170008487 metal binding site [ion binding]; metal-binding site 509170008488 conserved cis-peptide bond; other site 509170008489 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 509170008490 dihydrodipicolinate synthase; Region: dapA; TIGR00674 509170008491 dimer interface [polypeptide binding]; other site 509170008492 active site 509170008493 catalytic residue [active] 509170008494 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 509170008495 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 509170008496 ATP binding site [chemical binding]; other site 509170008497 active site 509170008498 substrate binding site [chemical binding]; other site 509170008499 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170008500 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170008501 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of transporter (formate/nitrite transporter family) (part 1) 509170008502 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of transporter (formate/nitrite transporter family) (part 2) 509170008503 recombination factor protein RarA; Reviewed; Region: PRK13342 509170008504 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170008505 Walker A motif; other site 509170008506 ATP binding site [chemical binding]; other site 509170008507 Walker B motif; other site 509170008508 arginine finger; other site 509170008509 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 509170008510 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 509170008511 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 509170008512 hypothetical protein; Provisional; Region: PRK05170 509170008513 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170008514 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170008515 Small integral membrane protein [Function unknown]; Region: COG5487; cl17674 509170008516 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 509170008517 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 509170008518 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 509170008519 nucleotide binding site/active site [active] 509170008520 HIT family signature motif; other site 509170008521 catalytic residue [active] 509170008522 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 509170008523 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 509170008524 minor groove reading motif; other site 509170008525 helix-hairpin-helix signature motif; other site 509170008526 substrate binding pocket [chemical binding]; other site 509170008527 active site 509170008528 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 509170008529 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 509170008530 DNA binding and oxoG recognition site [nucleotide binding] 509170008531 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 509170008532 Peptidase family M23; Region: Peptidase_M23; pfam01551 509170008533 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 509170008534 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 509170008535 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 509170008536 putative NAD(P) binding site [chemical binding]; other site 509170008537 putative substrate binding site [chemical binding]; other site 509170008538 catalytic Zn binding site [ion binding]; other site 509170008539 structural Zn binding site [ion binding]; other site 509170008540 dimer interface [polypeptide binding]; other site 509170008541 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509170008542 DNA-binding site [nucleotide binding]; DNA binding site 509170008543 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 509170008544 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 509170008545 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170008546 homodimer interface [polypeptide binding]; other site 509170008547 catalytic residue [active] 509170008548 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509170008549 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509170008550 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 509170008551 putative effector binding pocket; other site 509170008552 dimerization interface [polypeptide binding]; other site 509170008553 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 509170008554 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 509170008555 active site 509170008556 catalytic tetrad [active] 509170008557 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 509170008558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170008559 putative substrate translocation pore; other site 509170008560 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 509170008561 putative lipid binding site [chemical binding]; other site 509170008562 dihydrodipicolinate reductase; Provisional; Region: PRK00048 509170008563 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 509170008564 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 509170008565 chaperone protein DnaJ; Provisional; Region: PRK10767 509170008566 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 509170008567 HSP70 interaction site [polypeptide binding]; other site 509170008568 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 509170008569 substrate binding site [polypeptide binding]; other site 509170008570 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 509170008571 Zn binding sites [ion binding]; other site 509170008572 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 509170008573 dimer interface [polypeptide binding]; other site 509170008574 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 509170008575 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 509170008576 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 509170008577 HlyD family secretion protein; Region: HlyD_3; pfam13437 509170008578 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509170008579 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509170008580 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 509170008581 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 509170008582 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 509170008583 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170008584 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170008585 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 509170008586 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509170008587 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 509170008588 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509170008589 dimerization interface [polypeptide binding]; other site 509170008590 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 509170008591 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 509170008592 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 509170008593 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 509170008594 putative active site [active] 509170008595 substrate binding site [chemical binding]; other site 509170008596 putative cosubstrate binding site; other site 509170008597 catalytic site [active] 509170008598 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 509170008599 substrate binding site [chemical binding]; other site 509170008600 16S rRNA methyltransferase B; Provisional; Region: PRK10901 509170008601 NusB family; Region: NusB; pfam01029 509170008602 putative RNA binding site [nucleotide binding]; other site 509170008603 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509170008604 S-adenosylmethionine binding site [chemical binding]; other site 509170008605 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 509170008606 Na2 binding site [ion binding]; other site 509170008607 putative substrate binding site 1 [chemical binding]; other site 509170008608 Na binding site 1 [ion binding]; other site 509170008609 putative substrate binding site 2 [chemical binding]; other site 509170008610 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170008611 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170008612 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 509170008613 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of glutathione S-transferase (partial) 509170008614 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170008615 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170008616 Transglycosylase SLT domain; Region: SLT_2; pfam13406 509170008617 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 509170008618 N-acetyl-D-glucosamine binding site [chemical binding]; other site 509170008619 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 509170008620 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 509170008621 ATP-grasp domain; Region: ATP-grasp; pfam02222 509170008622 AIR carboxylase; Region: AIRC; pfam00731 509170008623 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 509170008624 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170008625 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170008626 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170008627 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 509170008628 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 509170008629 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 509170008630 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 509170008631 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 509170008632 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 509170008633 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 509170008634 active site 509170008635 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 509170008636 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170008637 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170008638 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 509170008639 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 509170008640 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 509170008641 [2Fe-2S] cluster binding site [ion binding]; other site 509170008642 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 509170008643 hydrophobic ligand binding site; other site 509170008644 guanine deaminase; Provisional; Region: PRK09228 509170008645 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 509170008646 active site 509170008647 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 509170008648 active site 509170008649 Predicted membrane protein [Function unknown]; Region: COG2261 509170008650 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 509170008651 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 509170008652 dimerization domain [polypeptide binding]; other site 509170008653 dimer interface [polypeptide binding]; other site 509170008654 catalytic residues [active] 509170008655 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 509170008656 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 509170008657 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 509170008658 putative metal binding site [ion binding]; other site 509170008659 putative homodimer interface [polypeptide binding]; other site 509170008660 putative homotetramer interface [polypeptide binding]; other site 509170008661 putative homodimer-homodimer interface [polypeptide binding]; other site 509170008662 putative allosteric switch controlling residues; other site 509170008663 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 509170008664 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 509170008665 trmE is a tRNA modification GTPase; Region: trmE; cd04164 509170008666 G1 box; other site 509170008667 GTP/Mg2+ binding site [chemical binding]; other site 509170008668 Switch I region; other site 509170008669 G2 box; other site 509170008670 Switch II region; other site 509170008671 G3 box; other site 509170008672 G4 box; other site 509170008673 G5 box; other site 509170008674 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 509170008675 membrane protein insertase; Provisional; Region: PRK01318 509170008676 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 509170008677 hypothetical protein; Provisional; Region: PRK14386 509170008678 Ribonuclease P; Region: Ribonuclease_P; pfam00825 509170008679 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399